Evidence-Based Guide to Cognitive Screening Measures Guideline
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Subjective Cognitive Complaints, Affective Distress, and Objective Cognitive Performance in Mild Traumatic Brain Injury
University of New Mexico UNM Digital Repository Psychology ETDs Electronic Theses and Dissertations Summer 7-2020 Subjective Cognitive Complaints, Affective Distress, and Objective Cognitive Performance in Mild Traumatic Brain Injury Brandi Seaman Follow this and additional works at: https://digitalrepository.unm.edu/psy_etds Part of the Psychology Commons Recommended Citation Seaman, Brandi. "Subjective Cognitive Complaints, Affective Distress, and Objective Cognitive Performance in Mild Traumatic Brain Injury." (2020). https://digitalrepository.unm.edu/psy_etds/309 This Dissertation is brought to you for free and open access by the Electronic Theses and Dissertations at UNM Digital Repository. It has been accepted for inclusion in Psychology ETDs by an authorized administrator of UNM Digital Repository. For more information, please contact [email protected], [email protected], [email protected]. Brandi Seaman Candidate Psychology Department This dissertation is approved, and it is acceptable in quality and form for publication: Approved by the Dissertation Committee: Ronald Yeo, Ph.D., Co-Chairperson Steven Verney, Ph.D. Co-Chairperson Richard Campbell, Ph.D. James Cavanagh, Ph.D. i Subjective Cognitive Complaints, Affective Distress, and Objective Cognitive Performance in Mild Traumatic Brain Injury by BRANDI SEAMAN, M.S. B.A., Neuroscience, Scripps College, 2013 M.S., Psychology, University of New Mexico, 2017 DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Psychology The University of New Mexico Albuquerque, New Mexico July, 2020 ii ACKNOWLEDGMENTS I would like to express my gratitude to my mentor, Dr. Ron Yeo, whose expertise, guidance, and patience has been invaluable. His willingness to give his time so generously and his encouragement made it possible to achieve this goal. -
(MCI) and Dementias in Your Clinical Practice
6/6/18 Assessment, Identification, and Management of Mild Cognitive Impairment (MCI) and Dementias in Your Clinical Practice Mark Hogue, Psy.D. Donald McAleer, Psy.D., ABPP Northshore Neurosciences Overview • MCI • Definitions, Subtypes, Screening/ assessment • Dementias • Definitions, Subtypes, Screening / Assessment • Management of Cognitive issues for the general clinician • Referrals/ treatments • Family • Legal / Driving 1 6/6/18 Erie Times-News June 3, 2018 Dementia and Mild Cognitive Impairment • Globally, the number of people diagnosed with dementia is increasing every year at an alarming rate. There are currently over 46.8 million people living with dementia and this is estimated to rise to 131.5 million people by 2050. (Tozer, 7/5/17) • Dementia • A loss of cognitive processes from a prior level of cognitive processes, as compared to age-mates, and due to a pathophysiological process. • MCI • An intermediate step between normal cognition and dementia • A measurable deficit in at least one domain, absent dementia and showing no appreciable deficit in ADL functioning 2 6/6/18 Mild Cognitive Impairment • Diagnos(c concepts to describe cogni(ve change in aging • Benign senescent forge-ulness (BSF) – Kral, 1962 • Mild Cogni?ve Impairment (MCI) – Reisberg et al., 1982 • Age-Associated Memory Impairment (AAMI) – CooK et al., 1986 • Late-life forge-ulness (LLF) – BlacKford & La Rue, 1989 • Age-Associated Cogni?ve Decline (AACD) – Levy et al., 1994 • Cogni?ve Impairment No Demen?a (CIND) – Graham et al., 1997 • Amnes?c Mild Cogni?ve -
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Shenkin et al. BMC Medicine (2019) 17:138 https://doi.org/10.1186/s12916-019-1367-9 RESEARCHARTICLE Open Access Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method Susan D. Shenkin1, Christopher Fox2, Mary Godfrey3, Najma Siddiqi4, Steve Goodacre5, John Young6, Atul Anand7, Alasdair Gray8, Janet Hanley9, Allan MacRaild8, Jill Steven8, Polly L. Black8, Zoë Tieges1, Julia Boyd10, Jacqueline Stephen10, Christopher J. Weir10 and Alasdair M. J. MacLullich1* Abstract Background: Delirium affects > 15% of hospitalised patients but is grossly underdetected, contributing to poor care. The 4 ‘A’s Test (4AT, www.the4AT.com) is a short delirium assessment tool designed for routine use without special training. Theprimaryobjectivewastoassesstheaccuracyofthe4ATfor delirium detection. The secondary objective was to compare the 4AT with another commonly used delirium assessment tool, the Confusion Assessment Method (CAM). Methods: This was a prospective diagnostic test accuracy study set in emergency departments or acute medical wards involving acute medical patients aged ≥ 70. All those without acutely life-threatening illness or coma were eligible. Patients underwent (1) reference standard delirium assessment based on DSM-IV criteria and (2) were randomised to either the index test (4AT, scores 0–12; prespecified score of > 3 considered positive) or the comparator (CAM; scored positive or negative), in a random order, using computer-generated pseudo-random numbers, stratified by study site, with block allocation. Reference standard and 4AT or CAM assessments were performed by pairs of independent raters blinded to the results of the other assessment. Results: Eight hundred forty-three individuals were randomised: 21 withdrew, 3 lost contact, 32 indeterminate diagnosis, 2 missing outcome, and 785 were included in the analysis. -
Development and Validation of the 4AT: a New Rapid Screening Tool for Delirium
Development and validation of the 4AT: a new rapid screening tool for delirium REC no. Scotland 15/SS/0071 England 15/YH/0317 R&D no. Edinburgh 2015/0347 Sheffield 18021 Bradford 1949 International Standard Randomised Controlled Trial Number: ISRCTN 53388093 UK Clinical Research Network: ID 19502 Funding Acknowledgement: This project was funded by the National Institute for Health Research Health Technology Assessment Programme (project number 11/143/01) Chief Investigator Professor Alasdair MacLullich Professor of Geriatric Medicine Edinburgh Delirium Research Group Geriatric Medicine Unit University of Edinburgh Room F1424 Royal Infirmary of Edinburgh 51 Little France Crescent Edinburgh EH16 4TJ tel +44 (0) 131 242 6481 fax +44 (0) 131 242 6370 4AT Study Protocol Version 5, 28th July 2015 Page 1 of 29 Co-investigator and Collaborators Christopher Fox, Reader in Psychiatry and Honorary Consultant in Old Age Psychiatry, University of East Anglia Mary Godfrey, Reader in Health and Social Care, Institute of Health Sciences, University of Leeds Najma Siddiqi, Consultant Psychiatrist, Bradford District NHS Care Trust, and Clinical Senior Lecturer, University of York Steve Goodacre, Professor of Emergency Medicine, School of Health and Related Research, University of Sheffield John Young, Professor of Elderly Care Medicine, Academic Unit of Elderly Care and Rehabilitation, University of Leeds Atul Anand, Clinical Research Fellow (Cardiovascular Sciences and Geriatric Medicine), University of Edinburgh Susan Shenkin, Clinical Senior Lecturer -
People with Dementia As Witnesses to Emotional Events
The author(s) shown below used Federal funds provided by the U.S. Department of Justice and prepared the following final report: Document Title: People with Dementia as Witnesses to Emotional Events Author: Aileen Wiglesworth, Ph.D., Laura Mosqueda, M.D. Document No.: 234132 Date Received: April 2011 Award Number: 2007-MU-MU-0002 This report has not been published by the U.S. Department of Justice. To provide better customer service, NCJRS has made this Federally- funded grant final report available electronically in addition to traditional paper copies. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice. This document is a research report submitted to the U.S. Department of Justice. This report has not been published by the Department. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice. FINAL TECHNICAL REPORT PRINCIPAL INVESTIGATOR: Laura Mosqueda, M.D. INSTITION: The Regents of the University of California, UC, Irvine, School of Medicine, Program in Geriatrics GRANT NUMBER: 2007-MU-MU-0002 TITLE OF PROJECT: People with Dementia as Witnesses to Emotional Events AUTHORS: Aileen Wiglesworth, PhD, Laura Mosqueda, MD DATE: December 23, 2009 Abstract Purpose: Demented elders are often the only witnesses to crimes against them, such as physical or financial elder abuse, yet they are disparaged and discounted as unreliable. Clinical experience with this population indicates that significant emotional experiences may be salient to people with dementia, and that certain behaviors and characteristics enhance their credibility as historians. -
Frontotemporal Dementia Disease and Frontal and Temporal Variant a Study
Downloaded from jnnp.bmjjournals.com on 17 July 2006 A study of stereotypic behaviours in Alzheimer’s disease and frontal and temporal variant frontotemporal dementia S Nyatsanza, T Shetty, C Gregory, S Lough, K Dawson and J R Hodges J. Neurol. Neurosurg. Psychiatry 2003;74;1398-1402 doi:10.1136/jnnp.74.10.1398 Updated information and services can be found at: http://jnnp.bmjjournals.com/cgi/content/full/74/10/1398 These include: References This article cites 22 articles, 10 of which can be accessed free at: http://jnnp.bmjjournals.com/cgi/content/full/74/10/1398#BIBL 4 online articles that cite this article can be accessed at: http://jnnp.bmjjournals.com/cgi/content/full/74/10/1398#otherarticles Rapid responses You can respond to this article at: http://jnnp.bmjjournals.com/cgi/eletter-submit/74/10/1398 Email alerting Receive free email alerts when new articles cite this article - sign up in the box at the service top right corner of the article Notes To order reprints of this article go to: http://www.bmjjournals.com/cgi/reprintform To subscribe to Journal of Neurology, Neurosurgery, and Psychiatry go to: http://www.bmjjournals.com/subscriptions/ Downloaded from jnnp.bmjjournals.com on 17 July 2006 1398 PAPER A study of stereotypic behaviours in Alzheimer’s disease and frontal and temporal variant frontotemporal dementia S Nyatsanza, T Shetty, C Gregory, S Lough, K Dawson, J R Hodges ............................................................................................................................... J Neurol Neurosurg Psychiatry 2003;74:1398–1402 Objective: To document the prevalence and pattern of stereotypic behaviour in patients with Alzheimer’s dementia and frontal and temporal variants of frontotemporal dementia. -
Delirium Screening in the Emergency Department: a Systematic Review and Meta-Analysis
Delirium Screening in the Emergency Department: A Systematic Review and Meta-analysis Qian Zhang Lanzhou University Meixi Chen Lanzhou University Liangying Hou Lanzhou University Ziqi Guo Lanzhou Universiry Qing Zhang Lanzhou University Baoshan Di Gansu Provincial Hospital Long Ge ( [email protected] ) Lanzhou University Research article Keywords: Delirium, Diagnosis, Emergency department, Systematic review Posted Date: October 30th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-97690/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/15 Abstract Background: Delirium is a complex syndrome characterized by a disturbance in attention and awareness, with a prevalence of 10-20% in patients admitted to the Emergency Department (ED). Screening tools have been developed to identify delirium in the ED, but their accuracy of screening remains unclear. To address this challenge, we conducted a comprehensive meta-analysis to systematically review the accuracy of delirium screening tools currently being used to assess ED patients. Methods: PubMed, PsycINFO, EMBASE, and the Cochrane Library were searched. Studies involving ED inpatients which compared diagnostic tools with the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria as a reference standard were included. Two reviewers independently screened the studies, extracted data, and assessed the quality of studies using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 scale. We conducted a conventional meta-analysis for each screening tool. Then we used network meta-analysis method to calculate the relative sensitivity and specicity among the diagnostic tests. The diagnostic accuracies were then ranked through the superiority index. -
Comparing Methods to Evaluate Cognitive Deficits in Commercial Airline Pilots
Comparing Methods to Evaluate Cognitive Deficits in Commercial Airline Pilots Joshua Potocko, MD/MPH UCSF Occupational and Environmental Medicine Residency 30 Min Background Philosophy Scope Comparisons Evidence Review: Example Questions for the Group BACKGROUND LCDR Joshua R. Potocko, MC (FS/FMF), USN “The views expressed in this presentation reflect the results of research conducted by the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government.” Potocko’s 6 Proclamations: Certain baseline cognitive functions decline with age. Within an individual, these declines are difficult to predict. Between individuals, different types of decline are variable. Understanding the following are critically important to aviation safety: Age-related declines Temporary disturbances in cognitive function, Stable (or progressive) baseline disturbances due to injury, illness, disease, medication, and substance use. When does cognitive dysfunction become unsafe? Cognitive Function Typical, Normal, Adequate, Average Cognitive Inefficiency Circadian, Fatigue, Mood, Stress Cognitive Deficiency Injury, Illness, Meds, Substances Cognitive Disability Above plus regulatory decisions => requires safety factor Baseline New Baseline Unfit Period Injury Illness Meds Baseline Progressive Decline Age XX? Permanently Unfit Disease? PHILOSOPHY Research Question: What is the “best” way to evaluate cognitive deficits in airline pilots? Best: historical? expert opinion?...or -
Standard Operating Procedures for Outcome Assessment Version 10
Outcome Assessment SOP April 12, 2018 Standard Operating Procedures for Outcome Assessment Version 10 1 Outcome Assessment SOP April 12, 2018 Table of Contents Approach to Outcome Assessment .................................................................................................. 5 Description of the Flexible Outcome Assessment Battery ................................................................. 5 Schedule of Assessments.................................................................................................................. 5 Schedule for Follow-up Assessment Windows ............................................................................... 6 Flexible Outcome Assessment Battery Framework Table ............................................................. 7 General Test Administration Guidelines ........................................................................................... 8 Examiner Qualifications and Battery Certification ............................................................................. 8 Scheduling and Coordinating Follow-Up Appointments .................................................................... 9 Conducting Follow-up Assessments in the Inpatient Setting .......................................................... 10 Test Selection and Time Limits ....................................................................................................... 10 Establishing Rapport and Provision of General Instructions ........................................................... 11 -
The PASAT and Traumatic Brain Injury
USING DISABILITY RATING SCALE RECOVERY CURVES TO PREDICT PASAT PERFORMANCE AFTER CLOSED HEAD INJURY ______________ A Thesis Presented to The Faculty of the Department of Psychology University of Houston ______________ In Partial Fulfillment Of the Requirements for the Degree of Master of Arts ______________ By Marika P. Faytell December, 2014 i USING DISABILITY RATING SCALE RECOVERY CURVES TO PREDICT PASAT PERFORMANCE AFTER CLOSED HEAD INJURY _______________ An Abstract of a Thesis Presented to The Faculty of the Department of Psychology University of Houston _______________ In Partial Fulfillment Of the Requirements for the Degree of Master of Arts _______________ By Marika P. Faytell December, 2014 iii ABSTRACT Objective: Existing predictive models of cognitive outcome following closed head injury have been largely based on a single time-point. Using archival data, the current study sought to improve upon existing models by predicting cognitive outcome at six months post-injury from a model of the rate of recovery of global functioning over four time-points: hospital discharge, one, three and six months post-injury. Participants and Method: Data from 91 individuals with complicated mild, moderate, and severe closed head injury who had participated in CPHS approved, NIH funded research that involved the collection of global outcome data and neuropsychological testing at six months post injury were used. Disability Rating Scale (DRS) scores from discharge, one, three and six months post-injury were selected along with Paced Auditory Serial Addition Test (PASAT) scores at six months post injury. The PASAT is a task that involves multiple cognitive domains, including processing speed, sustained and divided attention, and working and immediate memory. -
4AT Paper BMC Medicine
Manuscript 2nd revision Click here to access/download;Manuscript;Shenkin manuscript - Revised manuscript 2.docx Click here to view linked References 1 Title: Delirium detection in older acute medical inpatients: a 1 2 3 2 4 multicentre prospective comparative diagnostic test accuracy 5 6 7 3 study of the 4AT and the Confusion Assessment Method 8 9 10 11 4 12 13 14 1 15 5 Susan D Shenkin ([email protected]) 16 17 6 Christopher Fox ([email protected])2 18 19 7 Mary Godfrey ([email protected])3 20 21 4 22 8 Najma Siddiqi ([email protected]) 23 24 9 Steve Goodacre ([email protected])5 25 26 6 27 10 John Young ([email protected]) 28 29 11 Atul Anand ([email protected])7 30 31 8 32 12 Alasdair Gray ([email protected]) 33 34 13 Janet Hanley ([email protected])9 35 36 14 Allan MacRaild ([email protected])8 37 38 39 15 Jill Steven ([email protected])8 40 41 16 Polly L Black ([email protected])8 42 43 1 44 17 Zoë Tieges ([email protected]) 45 46 18 Julia Boyd ([email protected])10 47 48 10 49 19 Jacqueline Stephen ([email protected]) 50 51 20 Christopher J Weir ([email protected])10 52 53 1 54 21 Alasdair MJ MacLullich ([email protected]) 55 56 22 57 58 59 60 1 61 62 63 64 65 1 Institutional addresses 1 2 3 2 1. -
Mini Mental State Examination and Logical Memory Scores for Entry Into Alzheimer’S Disease Trials Kimberly R
Chapman et al. Alzheimer's Research & Therapy (2016) 8:9 DOI 10.1186/s13195-016-0176-z RESEARCH Open Access Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials Kimberly R. Chapman1, Hanaan Bing-Canar1, Michael L. Alosco1,2, Eric G. Steinberg1, Brett Martin1,3, Christine Chaisson1,3,4, Neil Kowall1,2,5,6, Yorghos Tripodis1,4 and Robert A. Stern1,2,7,8* Abstract Background: Specific cutoff scores on the Mini Mental State Examination (MMSE) and the Logical Memory (LM) test are used to determine inclusion in Alzheimer’s disease (AD) clinical trials and diagnostic studies. These screening measures have known psychometric limitations, but no study has examined the diagnostic accuracy of the cutoff scores used to determine entry into AD clinical trials and diagnostic studies. Methods: ClinicalTrials.gov entries were reviewed for phases II and III active and recruiting AD studies using the MMSE and LM for inclusion. The diagnostic accuracy of MMSE and LM-II cutoffs used in AD trials and diagnostic studies was examined using 23,438 subjects with normal cognition, mild cognitive impairment (MCI), and AD dementia derived from the National Alzheimer’s Coordinating Center database. Results: MMSE and LM cutoffs used in current AD clinical trials and diagnostic studies had limited diagnostic accuracy, particularly for distinguishing between normal cognition and MCI, and MCI from AD dementia. The MMSE poorly discriminated dementia stage. Conclusions: The MMSE and LM may result in inappropriate subject enrollment in large-scale, multicenter studies designed to develop therapeutics and diagnostic methods for AD. Keywords: Alzheimer’s disease, Clinical trials, MMSE, Logical Memory, Eligibility, Mild cognitive impairment, Neurodegenerative disease Background puncture, positron emission tomography) [1–3], these Alzheimer’s disease (AD) clinical trials and diagnostic are invasive procedures typically conducted following studies are responsible for the testing and development initial screening methods.