AN ORAL HISTORY OF NEUROPSYCHOPHARMACOLOGY THE FIRST FIFTY YEARS Peer Interviews Volume Three: Neuropharmacology Copyright © 2011 ACNP Thomas A. Ban (series editor) AN ORAL HISTORY OF NEUROPSYCHOPHARMACOLOGY Fridolin Sulser (volume editor) VOLUME 3: NEUROPHARMACOLOGY All rights reserved. No part of this book may be used or reproduced in any manner without written permission from the American College of Neuropsychopharmacology (ACNP). Library of Congress Cataloging-in-Publication Data Thomas A. Ban, Fridoln Sulser (eds): An Oral History of Neuropsychopharmacology: The First Fifty Years, Peer Interviews Includes bibliographical references and index ISBN: 1461161614 ISBN-13: 9781461161615 1. Neuropharmacology 2. Neurotransmitterr era 3. Mode of action of psychotropic drugs 4. Psychotropic drug development Publisher: ACNP ACNP Executive Office 5034A Thoroughbred Lane Brentwood, Tennessee 37027 U.S.A. Email:
[email protected] Website: www.acnp.org Cover design by Jessie Blackwell; JBlackwell Design www.jblackwelldesign.com AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY AN ORAL HISTORY OF NEUROPSYCHOPHARMACOLOGY THE FIRST FIFTY YEARS Peer Interviews Edited by Thomas A. Ban Co-editors Volume 1: Starting Up - Edward Shorter Volume 2: Neurophysiology - Max Fink Volume 3: Neuropharmacology - Fridolin Sulser Volume 4: Psychoharmacology - Jerome Levine Volume 5: Neuropsychopharmacology - Samuel Gershon Volume 6: Addiction - Herbert D. Kleber Volume 7: Special Areas - Barry Blackwell Volume 8: Diverse Topics - Carl Salzman Volume 9: Update - Barry Blackwell Volume 10: History of the ACNP - Martin M. Katz VOLUME 3 NEUROPHARMACOLOGY ACNP 2011 VOLUME 3 Fridolin Sulser NEUROPHARMACOLOGY The Neurotransmitter Era in Neuropsychopharmacology Preface Thomas A. Ban Dedicated to the Memory of Bernard B. Brodie, President ACNP, 1965 PREFACE Thomas A. Ban In 1957 Ralph Gerard coined the term “psychotropic drugs” for chemicals which can control or induce mental pathology.1 Neuropharmacology studies the molecular substrate involved in the mode of action of these drugs.