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3 Genes and Disease
Brain Imaging Henry N. Wagner, Jr. Brain Imaging: The Chemistry of Mental Activity Henry N. Wagner, Jr., MD Professor of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Professor Emeritus of Medicine and Radiology Johns Hopkins School of Medicine Baltimore, MD, USA ISBN 978-1-84800-307-1 e-ISBN 978-1-84800-308-8 DOI: 10.1007/978-1-84800-308-8 British Library Cataloguing in Publication Data Library of Congress Control Number: 2008940826 © Springer-Verlag London Limited 2009 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored, or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licenses issued by the Copyright Licensing Agency. Enquiries concerning reproduction outside those terms should be sent to the publishers. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specifi c statement that such names are exempt from the relevant laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Printed on acid-free paper Springer Science + Business Media springer.com Dedication To all the wonderful students, technologists and faculty in Nuclear Medicine at Johns Hopkins 1958–2008. -
Of Sciences of the UNITED STATES of AMERICA
ProceedIngs OF THE National Academy of Sciences OF THE UNITED STATES OF AMERICA November 1980 Volume 77, Number 11 pp. 6255-6942 Table of Contents INFORMATION TO CONTRIBUTORS 111-v AUTHOR INDEX vii Physical Sciences APPLIED MATHEMATICAL SCIENCES Computers-Present and future: Introduction to the symposium E. R. Piore 6255 Computers-Work in progress Herman H. Goldstine 6256-6259 Computers-Small computers: Past, present, and future Bernard M. Oliver 6260-6261 Computers-The software situation Jacob T. Schwartz 6262-6263 Computers-Non-numerical computation Herbert A. Simon 6264-6268 APPLIED PHYSICAL SCIENCES Dedicated-site, interim storage of high-level nuclear waste as part of the E-an Zen 6269-6271 management system Phase separation in mixtures of ionized iron in a hydrogen plasma B. J. Alder, E. L. Pollock, and J. P. 6272-6274 (asymmetric plasma mixtures/hypernetted chain/molecular dynamics) Hansen ASTRONOMY Statistical invalidation of the Hubble law (galaxies/cosmology/redshift- J. F. Nicoll, D. Johnson, I. E. Segal, 6275-6279 distance relationship) and W. Segal CHEMISTRY Synthesis and characterization of a photosensitive interface for hydrogen Dana C. Bookbinder, James A. Bruce, 6280-6284 generation: Chemically modified p-type semiconducting silicon Raymond N. Dominey, Nathan S. photocathodes (solar energy/photoelectrochemistry/energy conversion) Lewis, and Mark S. Wrighton Chemical potential, Teller's theorem, and the scaling of atomic and molecular Norman H. March and Robert G. Parr 6285-6288 energies (Thomas-Fermi theory/electronegativity) 25Mg NMR in DNA solutions: Dominance of site binding effects (alkaline earth D. Murk Rose, M. L. Bleam, M. T. 6289-6292 ions/ion condensation theory/NMR relaxation) Record, Jr., and R. -
AN ORAL HISTORY of NEUROPSYCHOPHARMACOLOGY the FIRST FIFTY YEARS Peer Interviews
AN ORAL HISTORY OF NEUROPSYCHOPHARMACOLOGY THE FIRST FIFTY YEARS Peer Interviews Volume Three: Neuropharmacology Copyright © 2011 ACNP Thomas A. Ban (series editor) AN ORAL HISTORY OF NEUROPSYCHOPHARMACOLOGY Fridolin Sulser (volume editor) VOLUME 3: NEUROPHARMACOLOGY All rights reserved. No part of this book may be used or reproduced in any manner without written permission from the American College of Neuropsychopharmacology (ACNP). Library of Congress Cataloging-in-Publication Data Thomas A. Ban, Fridoln Sulser (eds): An Oral History of Neuropsychopharmacology: The First Fifty Years, Peer Interviews Includes bibliographical references and index ISBN: 1461161614 ISBN-13: 9781461161615 1. Neuropharmacology 2. Neurotransmitterr era 3. Mode of action of psychotropic drugs 4. Psychotropic drug development Publisher: ACNP ACNP Executive Office 5034A Thoroughbred Lane Brentwood, Tennessee 37027 U.S.A. Email: [email protected] Website: www.acnp.org Cover design by Jessie Blackwell; JBlackwell Design www.jblackwelldesign.com AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY AN ORAL HISTORY OF NEUROPSYCHOPHARMACOLOGY THE FIRST FIFTY YEARS Peer Interviews Edited by Thomas A. Ban Co-editors Volume 1: Starting Up - Edward Shorter Volume 2: Neurophysiology - Max Fink Volume 3: Neuropharmacology - Fridolin Sulser Volume 4: Psychoharmacology - Jerome Levine Volume 5: Neuropsychopharmacology - Samuel Gershon Volume 6: Addiction - Herbert D. Kleber Volume 7: Special Areas - Barry Blackwell Volume 8: Diverse Topics - Carl Salzman Volume 9: Update - Barry Blackwell Volume 10: History of the ACNP - Martin M. Katz VOLUME 3 NEUROPHARMACOLOGY ACNP 2011 VOLUME 3 Fridolin Sulser NEUROPHARMACOLOGY The Neurotransmitter Era in Neuropsychopharmacology Preface Thomas A. Ban Dedicated to the Memory of Bernard B. Brodie, President ACNP, 1965 PREFACE Thomas A. Ban In 1957 Ralph Gerard coined the term “psychotropic drugs” for chemicals which can control or induce mental pathology.1 Neuropharmacology studies the molecular substrate involved in the mode of action of these drugs.