Dr.P.S.Rajinikanth Associate Professor Department Of

Home , Arya (actor)

Dr.P.S.Rajinikanth Associate Professor Department of Pharmaceutical Sciences School of Pharmaceutical Sciences Mob No.:91-8939311260 Email:[email protected], [email protected] Webpage:https://scholar.google.co.in/citations

Education Qualification

Organization Year of award B.Pharm TN Dr.MGR medical 1999 University, Chennai M.Pharm Indian Institute of 2002 (Pharmaceutics) Technology, BHU Ph.D. Indian Institute of 2007 (Pharmaceutics) Technology, BHU Post-Doctoral Training -- --

Professional Experience (In Years)

Teaching Experience: 11 Years Research Experience: 4 Years

Areas of Research (Maximum Five Bullet Points)

 Nano-carrier based targeted drug delivery specifically targeted for cancer therapy.  Self nanoemulsifying drug delivery to improve the bioavailability of poorly soluble drugs  Biomaterial based nano-fibrous scaffold for diabetic wound healing

* Research/Consultancy Grants

Title of Projects Funding Duration Total grant Role Agency (Specific (PI/CO-PI) Dates) 1. Silk protein - biomaterial SERB-DST 22 Nov, 2019- 29.12L PI based nanofibrous 21 Nov, 2021 scaffold of containing deferoxamine and ferulic acid for rapid healing of diabetic foot ulcer 2. Trastuzumab and iRGD SERB-DST 26 Dec,2019- 51.15L PI decorated dual targeted 25Dec,2022 liposomes for targeted

delivery of Lycorine and Gefitinib for HER2 Positive Breast Cancer and its Brain Metastasis

3. Development and in-vitro Taylors 25 June, RM 40,000 PI and in-vivo evaluation of University 2014- Supersaturated Research 24June,2016 selfnanoemulsifying drug Grant , delivery systems to Malaysia enhance bioavailability of poorly soluble drug Dutasteride- 4. Investigation of organ Taylors 22 July, 2014- RM27,000 CO-PI specific toxicity from University 21 July 2016 therapeutic use of Research CoptisChinesis Grant , Malaysia 5. Development of a novel ERGS grant, 18 June 2012- RM 221,000 CO-PI chitosan-flavonoids Ministry of 17June 2015- (Propolis ethanolic Health, Govt of extracts) solid lipid MALAYSIA nanoparticle against biofilm formation by Enterococcus faecalis using in vitro and ex vivo human tooth models and validation of biofilm inhibition by gene expression profiling, 6. Development and Research 15 April 2011- RM 60,000 PI characterization of grant, 14 April,2013 itraconozole encapsulated International solid lipid nanoparticles as Medical nano-carrier to delivery University , across the blood-brain Malaysia barrier for brain targeted delivery

Publications

International 1. Yashi Agarwal, P.S Rajinikanth, Shivendu Ranjan, Upma Tiwari3, Prashant Pandey, Dilip Kumar Arya, Sneha Anand, Payal Deepak , J. Balasubramnaiam.Curcumin loaded polycaprolactone-/ polyvinyl alcohol-silk fibroin based electrospun nanofibrous mat for rapid healing of diabetic wound: an in-vitro and in-vivo studies. Accepted in

Int.J.Bio.Mac.mol 2021 (IF 5.16)

2. Shweta Jaiswal P.S. Rajnikanth, Sunita Thakur , Payal Deepak1 , Sneha Anand . A Review on Novel Ligand Targeted Delivery for Cardiovascular Disorder. Accepted in Current drug Delivery 2021 (IF 1.5)

3. Sunita Thakur , Shweta Jaiswal P.S. Rajnikanth, , Payal Deepak1 , Sneha Anand Novel Treatment strategies for Management of Psoriasis : Current update and Future Perspective. Accepted in Current drug Delivery 2021 (IF 1.5)

4. Payal Deepak, Rajinikanth PS, Sunita Thakur, Sneha Anand, Shweta Jaiswal, Balasubramaniam Jagdish . Gene based nanocarrier delivery for the treatment of hepatocellular carcinoma, Journal of Drug Delivery Science and Technology, 2020, 59(1), 101837.(IF 2.75) 5. Kumarappan Chidambaram, Cine Mathew John Sunil christu Das, Rajinikanth PS and siddalingam, Ventakesh Kumaran. Modulation of glucose transporter protein by polyphenolic extractof Ichnocarpus frutescens(L) W.T action in experimental type-2 diabetic rats. Indian J.Exp.biol , 2020, 58(1) , 172-180. (IF 1.09) 6. Manish Kumar and PS Rajinikanth. A Mini-Review on HER2 Positive Breast Cancer and its Metastasis: Resistance and Treatment Strategies. Current Nanomedicine, 2020,10(1), 1- 10. 7. Poonguzhali Subramanian, P. S. Rajnikanth, Manish Kumar, Kumarappan chidambram. In- Vitro and In-Vivo Evaluation of Supersaturated Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Dutasteride, Current drug delivery,17 (1), 74-86, 2020 (IF 1.6) 8. Kumarappan Chidambaram, P.S.Rajinikanth , Kumar venkatesh,Senthilraja Dharmalingam, Thiagaraja sellpan. In-vitro inhibitory effect of polyphenolic wxtract of Ichnocarous Frutescens on carbohydrarate digestive enzymes. Advances in Pharmacology and Pharmacy, 7 (1) . 2019, 14-21. 9. Manish kumar andNithya Shanthi, P.S.Rajinikanth. Preparation of Luliconazole nanocrystals for improvement of dissolution and natifungal activity, Heliyon, 2019 5(5), 1- 11. 10. Rajnish Kumar Yadav, Chandra Bhusan Tripathi, Shubhini A Saraf, Mohd Nazam Ansari, Abdulaziz S Saeedan, Sara Aldosary, Paruvathanahalli S Rajinikanth, Gaurav Kaithwas.Alpha-linolenic acid based nano-suspension protect against lipopolysaccharides induced mastitis by inhibiting NFκBp65, HIF-1α, and mitochondria-mediated apoptotic pathway. Toxicology and applied pharmacology, 377, 2019, 114628. (IF 3.5) 11. P.S.Rajinikanth, Fabian Davamani, TeikHwaOng; Ebenezer Chitra; Srinivasan Ramamurthy. "Inhibition of biofilms formed by Enterococcus faecalis by propolisnano formulation". PLOS ONE, 2017 12(3) , 1-22. (IF 4.1) 12. P.S.Rajinikanth and Subramanian.S, Development and in vivo evaluation of Selfnanoemulsifying drug delivery systems of dutasteride. Journal of Applied Pharmaceutical Science, 2017 , 7(4), 11-22. 13. P.S.Rajinikanth, PoonguzhaliSubramnaiam and ChitambarmKumarappan. Development and validation of a new RP-HPLC method for the estimation of dutasteride in bulk and pharmaceutical formulations. Journal of Applied Pharmaceutical Science. 2016, 6 (12), 47- 55.

14. P.S.Rajinikanth and Jestinchellian . Investigation on potential of nanostructured lipid carrier based hydrogel as for topical delivery of 5-Flurouracil. International journal of Nano medicine, 2016: (11). 1-11. (IF 5.2) 15. Sonali, Rahul PratapSinghb, GunjanSharmac, Lakshmi Kumaria, BiplobKochc,SanjaySingha, ShreekantBhartiRajinikanth PS ,Bajarangprasad L. Pandey, Madaswamy S. Muthu. RGD-TPGS decorated theranostic liposomes for brain targeted delivery. Colloids Surf B Biointerfaces. 2016 Nov 1;147:129-41. (IF 4.39 16. P.S.Rajinikanth and ChitambarmKumarappan, Topical delivery of 5- Fluorouracil via Nanocarrier: Preparation, in vitro and ex in vivo Characterization of Water-in-Oil Nanoemulsion. Tropical Journal of Pharmaceutical Research. 2016, 15 (11), 2311-2319. (IF 0.8) 17. Kumarappan, C., Srinivasan, R.,Jeevathayaparan, S. Rajinikanth, S., Naveen, H.S. Ichnocarpusfrutescens: a valuable medicinal plant, Pharmacology online, 2015,2(1), 18-37 18. Lim Wei Meng, P.S.Rajinikanth and ChitneniMallikarjun.. Formulation and delivery of Itraconazole to the brain using nanolipid carrier system. International journal of Nano medicine, 2014,9(1), 2117–2126. (IF 5.2) 19. Yong Tze Teen, AdinarayanaGorajana, PS Rajinikanth, SreenivasPatroSisinthy, NalamoluKoteswaraRao. Development and Optimization of Gastroretentive drug delivery system for Oseltamivir. Int. J. Drug Dev. & Res, 2013, 5 (1), 197-203. 20. P.S.Rajinikanth, Neo WoeiKeat, Sanjay Garg, Self-nanoemulsifying Drug Delivery Systems of Valsartan: Preparation and In-Vitro Characterization. 2012, Intr. J. Drug Delivery,4(2),30-41. 21. P.S.Rajinikanth, J. Balasubramaniam, M.Thilek kumar and Y.V. Rajesh, Spray Drying as an Approach for Enhancement of Dissolution and Bioavailability of Raloxifene Hydrochloride. Intr. J. Drug Delivery, 2012,4(2), 113-121. 22. P.S.Rajinikanth and B.Mishra, Stomach-site specific drug delivery system of clarithromycin for eradication of Helicobacter pylori”. Chem .Pharm .Bull, 2009, 57(10) 1068—1075. (IF 1.8) 23. P.S.Rajinikanth and B.Mishra, Floating in situ gelling system for stomach site-specific delivery of clarithromycin to eradicate H. Pylori., Journal of Control Release, 2008,4(1), 33-41. (IF 7.71) 24. P.S.Rajinikanth, and B.Mishra, Development and in vitro evaluation of floating in situ gelling system of acethydroxamic acid for clearance of H.pylori. Drug. Dev. Ind. Pharm, 2008,34, 577-584.(IF 2.4) 25. P.S.Rajinikanth, and B.Mishra, Development and evaluation of floating–mucoadhesive microspheres of clarithromycin for eradication of H.pylori. Chem. Pharm. Bull , 2008, 52(12),45-53. (IF 1.8) 26. P.S.Rajinikanth, J.Balasubramaniamand B.Mishra Development and evaluation of a novel floating in situ gelling system of amoxicillin for eradication of H.pylori. International Journal of Pharmaceutics, 2007,335 (1),114-122. (IF 4.2) 27. J. Balasubramaniam, P. S. Rajinikanth, JeevanBabu M. Vasudhac, Vinay, U. Rao, Sodium Alginate Microspheres of Metformin Hcl: Formulation and In Vitro Evaluation. Current Drug Delivery, 2007,4, 249-256. (IF 1.5)

28. P.S.Rajinikanth and B.Mishra, Preparation and In Vitro Characterization of Gellan based Floating Beads of Acetohydroxamic Acid for Eradication of H.pylori.,ActaPharmaceutica, , 2007,57 (1), 413–427. (IF 1.5) 29. P. S. Rajinikanth, J. Balasubramaniam, V. U. Rao, M. Vasudha, Formulation and in vitro characterization of sodium alginate based beads of glipizide, Acta Pharm. Sciencia , 2007,7,42-56.. 30. P.S.Rajinikanth, J.Balasubramaniamand B.Mishra, Immediate Release Tablets of Valsartan and Efavirenz: Role of Concentration of Superdisintegrants. , ARS Pharmaceutica, 2008,49(3), 229-243. 31. P.S.Rajinikanth, P.Kumar and B.Mishra., A review on osmotic pump drug delivery system. Journal of Pharmaceutical Research, 2006,21,32-41. 32. P.S.Rajinikanth, C. Sankar and B.Mishra, Sodium alginate Microspheres of Metoprolol Tartrate for Intranasal systemic Delivery: Development and Evaluation. Drug Delivery, 2003, 10 (1 ) , 21-28. (IF 4.9)

Author/s (Year), Title, Name of Journals, Volume (Issue), Page no. National

Author/s (Year), Title, Name of Journals, Volume (Issue), Page no. Book Chapters 1. Title: Helicobacter Pylori infection: Current Therapy and Future therapeutics strategies:InTech Europe open sciences, April,2014, 2. Snena Anand, Rajinikanth PS, Title: Alginate-based nanomaterials in drug delivery applications ( book: Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications, 1st Edition, Elsevier publication , 2020.

Author/s (Year), Title, Name of Book, Publisher, Edition, ISBN No., Page no. Authored Books 1. A text book of Novel Drug Delivery system, Published by Birla Publication (2020), New Delhi.

Author/s (Year), Title, Name of Book, Publisher, Edition, ISBN No., Page no.

Edited Books

Author/s (Year), Title, Name of Book, Publisher, Edition, ISBN No., Page no.

Patents

Inventors Title and Award/Application no. Awarded - Published -

Filed -

Research Supervision

Completed Ongoing PG/M.Phil 13 5 Ph.D - 06 Post-Doctoral - -

Honors, Recognition and Awards

 Gold medal award by International conference on pharmacy and pharmacology, held in Bangkok, THAINLAND, 11-13 DE, 2016.  Qualified Graduate Aptitude Test in Engineering (GATE) conducted by IIT- Kharagpur with 94.99.% (2000)  Awarding Senior Research Fellowship (SRF) from Feb 2003 to April, 2007 by University Grants Commission, Ministry of Human Resources Development, Govt Of India

Membership of Professional Bodies

 Malaysian Pharmaceutical Society  Controlled Release Society, Malaysia Chapter  Tamilnadu Pharmacy Council  IndianPharmaceutical Graduates association

Seminar/Conference/Symposia /Workshops Organised

- Countries Visited

 United Kingdom,  Singapore, Malaysia  Hong Kong, China  Thailand, Vietnam  Laos, Philippines Invited Lectures/Talks/Chair/Co-Chair in Seminar/Conference/Symposia /Workshops

 P.S.Rajinikanth and Subramanian .S. Development and invitro characterization of selfnanoemulsifying drug delivery of dutasteride. Presented in 13th MPS conference, 3-5 Nov, 2017, Penang, Malaysia  P.S.Rajinikanth and Subramanian .S, Development and in vivo evaluation of Selfnanoemulsifying drug delivery systems of dutasteride . Presented in ICPP conference, held in Bangkok, Thailand, Dec, 2016 6

 P.S.Rajinikanth and Subramanian .S, Selfnanoemulsifying drug delivery systems of poorly soluble drug dutasteride . Presented in ICPHS conference, held in KL, 18-20 march 2016  P.S.Rajinikanth and Subramanian . RP-HPLC method development and validation of dutasteride for bulk and dosage forms. Presented 6th Asia pacific pharma conference , held in KL, 11-13 July 2016  Preparation and Characterization of Water-in-Oil Nanoemulsion of 5-Fluorouracil to Enhance Skin Permeation for Treatment of Skin Diseases. P.S.Rajinikanth, Jestion Chelian and Shobana Mariappan, Presented in 5th FAPA conference, held in Kota kinabalu, 9-12 Oct,2014, Malaysia.  Development and In-Vitro Characterization of Self-Nanoemulsifying Drug Delivery Systems of Valsartan. P.S.Rajinikanth, Yeoh Suyu and Sanjay Garg. Oral presentation in International Conference on Pharmacy and Pharmacology to be held in Bangkok, Thailand, 2012.  Preparation and Bio-pharmaceutical evaluation of floating bead of amoxicillin for H.Pylori eradication, Presented in Malaysian Pharmaceutical conference, 2011, Kuala Lumpur, Malaysia.  Helicobacter Pylori Targeted delivery: Preparation and characterization of clarithromycin floating microspheres. Presented in Philippines Pharmaceutical Research Conference 2010, Manila, Philippines.  Stomach-specific drug delivery system for controlled release of clarithromycin for eradication Helicobacter pylori P.S.Rajinikanth and B.Mishra, presented in 14th biological Conference,2010, Bangkok, Thailand.  Stomach-specific drug delivery system for controlled release of acetohydroxamic acid for eradication Helicobacter pylori. P.S.Rajinikanth and B.Mishra . Presented in 20th national Singapore pharmacy congress held on 25th July, 2009 at Singapore.  Nanocrytalization technique for poorly soluble drugs Adiyaman R and P.S.Rajinikanth , Presented in Malaysian Pharmaceutical conference held on 10th October,2009 at Penang, Malaysia.  Development and evaluation stomach site-specific delivery of clarithromycin for clearance of H.pylori. P.S.Rajinikanth, G.Sharma and B.Mishra. Presented in National Seminar on "Controlled & Targeted Drug Delivery Nanotechnology" held on 18th March, 2007 at Sagar University, INDIA.  Stomach specific anti-H. Pylori therapy: preparation and characterization of acetohydroxamic acid loaded gellanh beads coated with chitosa . P.S.Rajinikanth, G.Sharma and B.Mishra, presented in 57th Indian Pharmaceutical Congress (IPC) held in Mumbai, 2006.  Floating in-situ gelling system for Controlled release of acetohydroxamic acid for eradication of H.pylori. P.S.Rajinikanth, S.Baghel and B.Mishra Presented in 56th IPC held at Hyderabad,2005,  Development and In-vitro Evaluation of Hydrophllic Matrix tablets of Diltiazem Hydrochloride, B.Mishra, A.Bansal, C. sankar and P.S.Rajinikanth, Presented in 55th IPC held at Kolkota, 2004.  Studies on Formulation and Evaluation of oral Osmaotically Controlled Release tablets of naproxen Sodium, B.Mishra, P.Kumar B.Bakde and P.S.Rajinikanth Presented in 55 th IPC held at Kolkota,2004

 Studies on sodium Alginate Microspheres of Metoprolo Tartrate for Intranasal Delivery , B.Mishra ,P.S.Rajinikanth ,A.Bansal and C.Sankar ,Presented in 54 th IPC held at Pune,2003 .  Studies on Glicalzide – Cyclodexrin Complexes and it’s Tablets. B.Mishra, S.Agarwal, A.K.Srivastava and P.S.Rajinikanth, Presented in 53 rd IPC held at New Delhi, 2002.

Additional Information (If Any)

 Google scholar citations: 1000  h-index: 14  i10 index: 16  https://scholar.google.co.in/citations?user=g6-RhUYAAAAJ&hl=en