Vaping in England: an Evidence Update Including Mental Health and Pregnancy, March 2020

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Vaping in England: an Evidence Update Including Mental Health and Pregnancy, March 2020 Vaping in England: an evidence update including mental health and pregnancy, March 2020 A report commissioned by Public Health England Authors: Ann McNeill1, Leonie Brose1, Robert Calder1, Linda Bauld2,3, Debbie Robson1 1 King’s College London 2 University of Edinburgh 3 Cancer Research UK Vaping in England: 2020 About Public Health England Public Health England exists to protect and improve the nation’s health and wellbeing, and reduce health inequalities. We do this through world-leading science, research, knowledge and intelligence, advocacy, partnerships and the delivery of specialist public health services. We are an executive agency of the Department of Health and Social Care, and a distinct delivery organisation with operational autonomy. We provide government, local government, the NHS, Parliament, industry and the public with evidence-based professional, scientific and delivery expertise and support. Public Health England Wellington House 133-155 Waterloo Road London SE1 8UG Tel: 020 7654 8000 www.gov.uk/phe Twitter: @PHE_uk Facebook: www.facebook.com/PublicHealthEngland © Crown copyright 2020 You may re-use this information (excluding logos) free of charge in any format or medium, under the terms of the Open Government Licence v3.0. To view this licence, visit OGL. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. Published March 2020 PHE publications PHE supports the UN gateway number: GW-1118 Sustainable Development Goals 2 Vaping in England 2020 Authors Ann McNeill1, Leonie Brose1, Robert Calder1, Linda Bauld2,3, Debbie Robson1 1 King’s College London 2 University of Edinburgh 3 Cancer Research UK Acknowledgements Chapter contributors: Gilda Spaducci1 (Chapter 5), Eleanor Gant1 (Chapter 6) Acknowledgements: Sofia Hemrage1 and Caterina Radu1 for their help with reviewing literature for the pregnancy systematic review and Taranjit Sehmbi1 for help with literature screening and data analyses used in the adult and youth chapters. 1 King’s College London Suggested citation McNeill, A., Brose, L.S., Calder, R., Bauld, L., and Robson, D. (2020). Vaping in England: an evidence update including mental health and pregnancy, March 2020: a report commissioned by Public Health England. London: Public Health England. 3 Vaping in England 2020 Contents About Public Health England 2 Contents 4 Conflict of interest statement 5 Acronyms and abbreviations 6 Executive summary 8 Chapter 1: Introduction 16 Chapter 2: Methods 31 Chapter 3: Vaping among young people 37 Chapter 4: Vaping among adults 64 Chapter 5: Systematic review of vaping among people with mental health conditions 113 Chapter 6: Systematic review of vaping in pregnancy and postpartum 151 References 186 Appendices 203 4 Vaping in England 2020 Conflict of interest statement Professor Ann McNeill is Professor of Tobacco Addiction and Vice Dean (Culture, Diversity and Inclusion) at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London. Professor McNeill leads the Nicotine Research Group in the Addictions Department, IoPPN and receives funding for projects from a variety of funders such as Cancer Research UK (CRUK) and the National Institute for Health Research (NIHR) and has no links with any tobacco or vaping product manufacturers. Professor McNeill is a NIHR Senior Investigator. The views expressed in this report are those of the authors and not necessarily those of the NIHR, or the Department of Health and Social Care. Dr Leonie Brose is a Senior Lecturer in the Nicotine Research Group, in the Addictions Department at the IoPPN, King’s College London. She has received funding from CRUK and Heart Research UK. She has no links with any tobacco or vaping product manufacturers. Dr Robert Calder is a Research Associate in the Nicotine Research Group in the Addictions Department, IoPPN, King’s College London, and has no links with any tobacco or vaping product manufacturers. Professor Linda Bauld is the Bruce and John Usher Chair of Public Health in the College of Medicine and Veterinary Medicine at the University of Edinburgh. She is a Director of the SPECTRUM consortium and holds the CRUK/BUPA Chair in Behavioural Research for Cancer Prevention at CRUK. She has no links with any tobacco or vaping product manufacturers. Dr Debbie Robson is a Senior Research Fellow in the Nicotine Research Group in the Addictions Department at the IoPPN, King’s College London. She is funded by the NIHR Applied Health Research (ARC) South London, Maudsley Charity and CRUK. She has no links with any tobacco or vaping product manufacturers. All authors are members of the SPECTRUM consortium. 5 Vaping in England 2020 Acronyms and abbreviations APS = Annual Population Survey ASH = Action on Smoking and Health ASH-A = ASH Smokefree Great Britain Adult survey ASH-Y = ASH Smokefree Great Britain Youth survey CES-D = Center for Epidemiological Studies − Depression CI = Confidence Interval CO = Carbon Monoxide expired air COREQ = Consolidated Criteria for Reporting on Qualitative Research CPD / CPW = Cigarettes Per Day / Cigarettes Per Week DSM = Diagnostic and Statistical Manual of Mental Disorders EVALI = E-cigarette, or vaping, product use associated lung injury FDA = Food and Drug Administration (US) FTND = Fagerstrom Test for Nicotine Dependence ITC = The International Tobacco Control Policy Evaluation Project IQR = Inter-Quartile Range K6 = Kessler Screening Scale for Psychological Distress MHC = Mental Health Condition MHRA = Medicines and Healthcare products Regulatory Agency NHIS = National Health Interview Survey NICE = National Institute for Health and Care Excellence NIDA = National Institute on Drug Abuse (US) NNAL = 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol NNK = 4-(methylnitrosamino)-1(3-pyridyl)-1-butanone NOS = Newcastle Ottawa Scale NRT = Nicotine Replacement Therapy OPN = Opinions and Lifestyles Survey OR = Odds Ratio PATH = The Population Assessment of Tobacco and Health Study PRAMS = Pregnancy Risk-Assessment Monitoring System PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses PROSPERO = The International Prospective Register of Systematic Reviews 6 Vaping in England 2020 PTSD = Post-Traumatic Stress Disorder RCT = Randomised Controlled Trial RR = Relative Risk SDD = Smoking Drinking and Drug use among young people in England (Survey) SD = Standard Deviation SMI = Serious Mental Illness SPD = Serious Psychological Distress STS = Smoking Toolkit Study THC = Tetrahydrocannabinol TPD = European Union Tobacco Products Directive TRPR = Tobacco and Related Products Regulations 2016 7 Vaping in England 2020 Executive summary 1. Introduction 1.1 Aim of the report This is the sixth report in a series of independent reports commissioned by Public Health England to summarise evidence on e-cigarettes to inform policies and regulations. Despite reductions in smoking prevalence, smoking remains the biggest single cause of preventable death and disease and a leading cause of health inequalities. So, alternative nicotine delivery devices which are less harmful could play a crucial role in reducing this health burden. This report presents updates on the prevalence of vaping among young people and adults and reviews literature on vaping among people with mental health conditions and pregnant women. A comprehensive e-cigarette safety review will be the focus of a future report. 1.2 Terminology We use the term ‘vaping products’ to describe e-cigarettes and refill containers (e-liquids). We use the term ‘vapers’ to refer to people who regularly use vaping products and ‘vaping’ as the act of using a vaping product. Our terms do not include cannabis vaping or the vaping of other illicit substances, which are not the subject of this report. 1.3 Current regulations Non-nicotine containing vaping products fall under the General Product Safety Regulations 2005, enforced by local trading standards. Nicotine-containing vaping products are regulated more stringently through the revised European Union Tobacco Products Directive (2014/40/EU) (TPD), translated into United Kingdom (UK) law through the Tobacco and Related Products Regulations 2016 (TRPR), which the government has committed to review by May 2021. 8 Vaping in England 2020 There are no medicinally licensed nicotine vaping products in the UK. Selling vaping products to anyone under 18 is prohibited and so is buying vaping products for anyone under 18. 1.4 Recent developments Nicotine vaping products have continued to evolve. The use of nicotine salt technology is becoming more popular. Between 20 May 2016 (implementation of TRPR) and 9 January 2020, the Medicines and Healthcare products Regulatory Agency (MHRA) had received 84 reports of 245 adverse reactions believed to be associated with vaping products that contain nicotine through its Yellow Card Scheme. A report is not proof that the reaction was caused by a vaping product, just that the reporter suspected it might have been. In the US, where there is a very different regulatory system for vaping products (including products used to vape cannabis), there was a spate of serious lung diseases and deaths that appeared to peak in late 2019. This outbreak seems to have been caused by people vaping the cannabis derivative tetrahydrocannabinol (THC) oil and vitamin E acetate. There has been no similar lung disease outbreak in England, although the MHRA has received reports of 4 deaths through its Yellow Card Scheme where vaping was suspected to be implicated
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