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DOCUMENT RESUME ED 042 219 24 CG 005 800 TITLE The Development of a Curriculum for Teaching Elementary and Secondary School Children the Dangers Inherent in the Use and Abuse of Dangerous Drugs. Final Progress Report. INSTITUTION Laredo Independent School District, Tex. SPONS AGENCY Office of Education (DHEW) ,Washington, D.C. BUREATI NO BR-9-G-067 PUB DATE 30 Sep 70 CONTRACT OEC -7 -9- 530067 -0123- (010) NOTE 545p.; Second Edition EDRS PRICE EDRS Price MF-$2.00 HC-$27.35 DESCRIPTORS *Curriculum Development, *Curriculum Guides, *Drug Abuse, Elementary School Students, Instructional Materials, Secondary School Students, *Social Problems, *Teaching Guides ABSTRACT This very extensive guide, designed in large measure by classroom teachers an' meant for use by classroom teachers, is one community's response to its drug problem. The completed guide, however, is designed for adaptation throughout the nation and in foreign countries. Material is offered for different school levels, with the primary grades receiving information introduced by the classroom teacher, focusing on mental health and character development. The concept of drugs as medicine and narcotics is presented at the upper elementary level. The approach in the secondary grades is through the established curriculum with units offered in English, Mathematics, Science, Health and Physical Education and Social Studies. Specific yet flexible guidelines are included at each grade level to help establish objectives, create motivation, and provide activities for enrichment and reinforcement. Glossaries and factual information which can help answer questions often asked are included, as well as letters to committee members and parents. (CJ) Laredo Independent School District C\I C\J CD W THE USE, MISUSE, AND ABUSE OF DRUGS AND NARCOTICS SECOND EDITION r-4 CV CV O Final Progress Report Proposal No. 9-G-067 Contract No. OEC-7-9-530067-0123-(010) THE DEVELOPMENT OF A CURRICULUM FOR TEACHING ELEMENTARY AND SECONDARY SCHOOL CHILDREN THE DANGERS INHERENT IN THE USE AND ABUSE OF DANGEROUS DRUGS Vidal M. Trevino Laredo Independent school District Laredo, Texas September 30, 1970 The research reported herein was performed pursuant to a contract with the Office of Education, U. S. Department of Health, Education, and Welfare. Contractors undertaking such projects under Government sponsorship are encouraged to express freely their professional judgment in the conduct of the project. Points of view or opinions stated do not, therefore, necessarily represent official Office of Educa- tion position or policy. U. S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Office of Educe.a 0 Bureau of Research gOo U.S. DEPARTMENT Of HEWN. EDUCATION & WELFARE OFFICE Of EDUCATION 2 THIS DOCUMENT NAS SEEN REPRODUCED EXACTLY AS RECEIVED FROM THE PERSON OR ORGANIZATION ORIGINATING 11.POINTS Of VIEW OR OPINIONS STATED DO NOT NECESSARILY REPRESENT OFFICIAL OFFICE Of EDUCATION POSITION OR POLICY. Outline-Contents OE Bureau of Research No. Contract No. OEC-7-9-530067.0123-(010) Period March, 1970- to September, 1970 Date of Submission September 30, 1970 Name of Institution:Laredo Independent School District Title of Project: THE DEVELOPMENT OF A CURRICULUM FOR TEACHING ELEMENTARY AND SECONDARY SCHOOL CHILDREN THE DANGERS INHERENT IN THE USE AND ABUSE OF DAN- GEROUS DRUGS. Name of Project Director: Vidal M. Trevino Office of Education Division or Staff Office:Region VII For Table of Contents, refer to following page. ?ce_jc.cz Signature of Contract Officer and Project Director Date THE USE, MISUSE, AND ABUSE OF DRUGS AND NARCOTICS TABLE OF CONTENTS I.Introduction page 1- 12 A. Public Support B. Local School Administrators' Support C. Gener fl Information page 13 - 19 II.Level I (grildes K, I, 2, and 3) page - 58 A. Introduction-basic information for the teacher B. Units C. Suggestions for Bulletin Board Displays page 59 - 63 III.Level II (grades 4, 5, and 6) page 64 - 141 A. Introduction-basic information for the teacher B. Units IV.Level III( grades 7, 3, and 9) page 142 - 143 A. English page 144 - 169 1. Introduction 2. Units - Dictionary, Library, Teaching Suggestions 3. Appendices B. Mathematics page 170 - 192 C. Social Studies page 193 - 215 I. Introduction 2. Units - Environment, Origin, Laws D. Life Science. page 216 - 236 E. Health and Physical Education page 237 - 251 1. Introduction 2. Units - Physical fitness and Health V.Level IV - grades 1G, 11, and 12 page 252 - 253 A. English page 254 - 269 1. Introduction 2. Units - Class discussions, News Media, Vocabulary,' Library 3. Appendices B. Mathematics page 270 - 288 1. Introduction 2. Units - Sets, Surveys, Percent 3. Appendices C. American History page 289 - 306 I. Introduction 2. Unit - B. C. 1492, 18th - 19th centuries; present D. Civics page 3U7 - 331 1. Introduction 2. Units - Legal and illegal distribution of drugs 3. Appendices E. Biology page 332351 1. Introduction 2. Units - Pharmacology, Therapeutic value 3. Glossary page 352 - 3S9 4. Resource Materials page 360 - 379 F. Chemistry page 380 - 389 1. Introduction 2. Units G. Health and Physical Education page 390 - 423 1. Introduction 2. Units - Health problems, Social and Cu! tural Implications VI: Appendices page 424 A. Appendix A - Glossary of specific terminology page 425 - 435 B. Appendix B - Glossary of Slang Terms (English and Spanish) page 436 - 458 C. Appendix C - Drugs Affecting the Mind (Legal and Illegal) page 459 - 475 D. Appendix D - Laws Regulating Sale and Distribution of Drugs an Narcoticspage 476 - 502 E. Appendix E - Basic Drug Information for the Teacher page 503 - 527 F. Appendix F - Selected Reference Materials page 528 - 540 1. Books 2. Films and Filmstrips 3. Transparencies 4. Periodicals 5. Posters 6. Drug Kits 7. Pamphlets LAREDO'S SUPPORTING ROLE 1. 07/Tx- OPEAmono LAREDO. TEXAS OFFICE OF THE MAYOR J. C. MARTI N, February 17, 1970 The City of Laredo takes pride in endorsing the efforts of theLaredo. Independent School District in relation to their program to combat the misuse and abuse of drugs. As Mayor of the City Ipledge our support in this endeavor and assure you that all or any of our departments stand ready to help you in anymanner that you see fit. We congratulate allthe umbers of the crmnittee which spent endless hours in preparingthis new section of your total curriculum. I know thatyour efforts will go a long way in eliminating this cancer which exists in our society. J. C. Martin, Jr. Mayor of the City of Laredo JCM,Jr./hcg 2 !Krebs) ?Public IS40610 LAREDO. TEXAS J. W. NIXON IIIIERINTZNOCNT February 16, 1970 Co-ordinating Committee on Drug Abuse 1618 Houston Laredo Independent School System Laredo, Texas 78040 Dear Committee Members: As an educator, I have always been concerned with anything that en- dangers the lives of our Laredo Public School children. I am deeply concerned, therefore, with our youth's use of dangerous substances. I strongly feel that the schools are the most strategically located institutions in which knowledge related to heroin, marihuana, and other drugs can be obtained. It is my firm belief that education is one of the answers to this latest of menaces. The development of a curriculum guide to be used in educating our students as to the dreadful use of harmful drugs is part of that answer. I want to pledge the support of my entire staff, teachers and administrators, to this program. I want to extend complete co-operation in putting it into our schools. I further Feel that the development of this guide will make significant contributions to other communities of our State and Nation. "---e<rely urs, c- Nixon, Superintendent o Public Schools JWN/acp 3 Tarebsublic chnvio LAREDO. TEXAS OFFICE OF: AMIIIITANT IILIPERINTIENOCHT February 13, 1970 Coordinating Committee on Drug Abuse Laredo Public Schools Laredo, Texas 78040 Dear Fellow-Workers: While I have spoken to you on several occasions in regards to the importance of the work you are doing in developing this course of study on drug abuse, I must compliment you on the wonderful attitude you have had in undertaking the project. Dedication is the word for it. Only people religiously dedicated to a purpose could have devoted more time and effort to any project than you have given to this one, and especially since you have worked without financial remuneration. As you as teachers very well know, there are other forms of re- muneration than money.You can take great pride in having done a job the results of which can touch every city in ever; state of this great Country of ours. Perhaps its influence can eviii be worldwide. Again the gratitude of fathers and mothers everywhere are due you, and certainly we of the Administration of Laredo Public Schools are most grateful for what you have done for humanity. Sincerely yours, Asst.- upt. Laredo Pub Schools RPSt.J/acp Yentsyk grallenderd 614,901g64,41 FEDERAL PROJECTS 1618 HOUSTON ST. RA 2-6366 LAREDO, TEXAS 78040 February 16, 1970 Mrs. Graciela C. Ramirez Curriculum Writer Drug Abuse Committee 1618 Houston St. Laredo, Texas Dear Mrs. Ramirez: The resources of Federal Projects are available to you and your Staff in developing the program for teaching the danger of harmful drugs. I personally have and will continue to give full support to the program in every way possible and assure you that all the staff of Federal Projects will assist in any way possible. Sincerely, rter S. Gaer Coordinator of Federal Projects PSG/pm 5 4,4,000, .% 2, RtszeW:9! CIGARROA MEDICAL BUILDING 1502 Logan Avenue LAREDO, TEXAS, 78040 March 2, 1970 Co-ordinating Committee on Drug Abuse 1618 Houston Laredo, Texas Dear Members, It is indeed with a feeling of great pride and singular personal satisfaction that I have read the curriculum guide on drug use and abuse developed by the committee of the Laredo Independent School District chaired by Mr.
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  • Polypharmacy Side Effect Prediction with Graph Convolutional Neural Network Based on Heterogeneous Structural and Biological Data

    Polypharmacy Side Effect Prediction with Graph Convolutional Neural Network Based on Heterogeneous Structural and Biological Data

    DEGREE PROJECT IN MATHEMATICS, SECOND CYCLE, 30 CREDITS STOCKHOLM, SWEDEN 2020 Polypharmacy Side Effect Prediction with Graph Convolutional Neural Network based on Heterogeneous Structural and Biological Data JUAN SEBASTIAN DIAZ BOADA KTH ROYAL INSTITUTE OF TECHNOLOGY SCHOOL OF ENGINEERING SCIENCES Polypharmacy Side Effect Prediction with Graph Convolutional Neural Network based on Heterogeneous Structural and Biological Data JUAN SEBASTIAN DIAZ BOADA Degree Projects in Scientific Computing (30 ECTS credits) Master’s Programme in Computer Simulations for Science and Engineering KTH Royal Institute of Technology year 2020 Supervisor at KI Algorithmic Dynamics Lab, Center for Molecular Medicine: Narsis A. Kiani Supervisor at KTH: Michael Hanke Examiner at KTH: Michael Hanke TRITA-SCI-GRU 2020:390 MAT-E 2020:097 Royal Institute of Technology School of Engineering Sciences KTH SCI SE-100 44 Stockholm, Sweden URL: www.kth.se/sci iii Acknowledgements This thesis and its experiments were performed in the Algorithmic Dynamics Lab of the Center for Molecular Medicine. Special thanks to Amir Amanzadi for creating the affinity score dataset, Jesper Tegnér for his comments analyz- ing results and Linus Johnson for his help with the Swedish translation. v Abstract The prediction of polypharmacy side effects is crucial to reduce the mortal- ity and morbidity of patients suffering from complex diseases. However, its experimental prediction is unfeasible due to the many possible drug combi- nations, leaving in silico tools as the most promising way of addressing this problem. This thesis improves the performance and robustness of a state-of- the-art graph convolutional network designed to predict polypharmacy side effects, by feeding it with complexity properties of the drug-protein network.