DRG2 Antibody Cat

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DRG2 Antibody Cat. No.: 60-339 DRG2 Antibody Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Mouse HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine This DRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 154-180 amino acids from the Central region of human DRG2. TESTED APPLICATIONS: WB APPLICATIONS: For WB starting dilution is: 1:1000 PREDICTED MOLECULAR 41 kDa WEIGHT: Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig CONJUGATE: Unconjugated September 27, 2021 1 https://www.prosci-inc.com/drg2-antibody-60-339.html PHYSICAL STATE: Liquid BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: DRG2 ALTERNATE NAMES: Developmentally-regulated GTP-binding protein 2, DRG-2, DRG2 ACCESSION NO.: P55039 PROTEIN GI NO.: 1706518 GENE ID: 1819 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40- BACKGROUND: transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq]. REFERENCES: 1) Song, H., et al. J. Biochem. 135(3):331-335(2004) 2) Bi, W., et al. Genome Res. 12(5):713-728(2002) 3) Li, B., et al. Biochim. Biophys. Acta 1491 (1-3), 196-204 (2000) : 4) Vlangos, C.N., et al. Cytogenet. Cell Genet. 88 (3-4), 283-285 (2000) : ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 27, 2021 2 https://www.prosci-inc.com/drg2-antibody-60-339.html.

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Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17P11.2 and the Syntenic Region of the Mouse
Downloaded from genome.cshlp.org on September 25, 2021 - Published by Cold Spring Harbor Laboratory Press Article Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse Weimin Bi,1,6 Jiong Yan,1,6 Paweł Stankiewicz,1 Sung-Sup Park,1,7 Katherina Walz,1 Cornelius F. Boerkoel,1 Lorraine Potocki,1,3 Lisa G. Shaffer,1 Koen Devriendt,4 Małgorzata J.M. Nowaczyk,5 Ken Inoue,1 and James R. Lupski1,2,3,8 Departments of 1Molecular & Human Genetics, 2Pediatrics, Baylor College of Medicine, 3Texas Children’s Hospital, Houston, Texas 77030, USA; 4Centre for Human Genetics, University Hospital Gasthuisberg, Catholic University of Leuven, B-3000 Leuven, Belgium; 5Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4J9, Canada Smith-Magenis syndrome (SMS) is a multiple congenital anomaly/mental retardation syndrome associated with behavioral abnormalities and sleep disturbance. Most patients have the same ∼4 Mb interstitial genomic deletion within chromosome 17p11.2. To investigate the molecular bases of the SMS phenotype, we constructed BAC/PAC contigs covering the SMS common deletion interval and its syntenic region on mouse chromosome 11. Comparative genome analysis reveals the absence of all three ∼200-kb SMS-REP low-copy repeats in the mouse and indicates that the evolution of SMS-REPs was accompanied by transposition of adjacent genes. Physical and genetic map comparisons in humans reveal reduced recombination in both sexes. Moreover, by examining the deleted regions in SMS patients with unusual-sized deletions, we refined the minimal Smith-Magenis critical region (SMCR) to an ∼1.1-Mb genomic interval that is syntenic to an ∼1.0-Mb region in the mouse.
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DRG2 (C-14): Sc-164232
SAN TA C RUZ BI OTEC HNOL OG Y, INC . DRG2 (C-14): sc-164232 BACKGROUND SOURCE DRG2 (developmentally regulated GTP binding protein 2) is a 364 amino acid DRG2 (C-14) is an affinity purified goat polyclonal antibody raised against a cytoplasmic protein involved in cell proliferation, differentiation and death. A peptide mapping near the C-terminus of DRG2 of human origin. member of the DRG subfamily of the GTP-binding protein superfamily, DRG2 is highly expressed in kidney, heart and skeletal muscle, with low levels found PRODUCT in thymus, colon, spleen, lung, small intestine and leukocytes. DRG2 under - Each vial contains 200 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide goes post-translational polyubiquitination, leading to proteolytic degradation. and 0.1% gelatin. DRG2 interacts with RWDD1 (RWD domain containing 1), and is encoded by a gene that is located in a region on human chromosome 17 associated with Blocking peptide available for competition studies, sc-164232 P, (100 µg Smith-Magenis syndrome (SMS). SMS is a disorder characterized by multiple peptide in 0.5 ml PBS containing < 0.1% sodium azide and 0.2% BSA). congenital anomalies, abnormal sleep patterns, maladaptive repetitive and self-injurious actions and behavior problems. APPLICATIONS DRG2 (C-14) is recommended for detection of DRG2 of mouse, rat and REFERENCES human origin by Western Blotting (starting dilution 1:200, dilution range 1. Schenker, T., Lach, C., Kessler, B., Calderara, S. and Trueb, B. 1994. A novel 1:100-1:1000), immunofluorescence (starting dilution 1:50, dilution range GTP-binding protein which is selectively repressed in SV40 transformed 1:50-1:500) and solid phase ELISA (starting dilution 1:30, dilution range fibroblasts.
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