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DDDC 2019 Organizing Committee Conference Sponsors 2 Drug Discovery and Development Colloquium 2018 VI Annual Conference June 13 - 15, 2019 DDDC 2019 Organizing Committee Skylar Connor, Conference Co-chair, SHraddHa THakkar, PH.D., Conference Co-chair, UAMS AAPS Student CHapter President, Student UAMS AAPS Student CHapter Sponsor, Faculty University of Arkansas for Medical Sciences • FDA National Center for Toxicological Research University of Arkansas Little Rock Ujwani Nukala, Organizing Committee, UAMS Cesar M. Compadre, PH.D., Conference Co-chair, AAPS Student CHapter Past-President, Student UAMS AAPS Student CHapter Co-Sponsor, University of Arkansas for Medical Sciences Faculty University of Arkansas Little Rock University of Arkansas for Medical Sciences Ting Lee, Organizing Committee, UAMS AAPS David Mery, Organizing Committee, UAMS Student CHapter Treasurer, Student AAPS Student CHapter CHair Elect, Student University of Arkansas for Medical Sciences. University of Arkansas for Medical Sciences University of Arkansas Little Rock Cord Carter, Organizing Committee, UAMS AAPS Pankaj Patyal, Organizing Committee, UAMS Student CHapter Secretary, Student AAPS Student CHapter Vice President, Student University of Arkansas for Medical Sciences University of Arkansas for Medical Sciences Taylor Connor, Organizing Committee, UAMS Nemu Saumyadip, Organizing Committee, AAPS Student Chapter Member, Student UAMS AAPS Student CHapter Member, Student University of Arkansas for Medical Sciences University of Arkansas for Medical Sciences PHuc Tran, Organizing Committee, UAMS AAPS Edward Selvik, Organizing Committee, UAMS Student CHapter Member, Student AAPS Student CHapter Member, Student University of Arkansas for Medical Sciences University of Arkansas for Medical Sciences University of Arkansas Little Rock Table of Contents DDDC 2019 Agenda 5 List of Poster Presenters 10 Speakers and Organizers Bios 11 Abstracts 23 3 Drug Discovery and Development Colloquium 2019 University of Arkansas for Medical Sciences I. Dodd Wilson Education Building Day 1, Thursday June 13, 2019 2:00-7:00 pm Registration Welcome and Opening Remarks Schwanda Flowers, Pharm.D. Interim Dean, Associate Dean for Administrative and Academic Affairs. Associate Professor, Pharmacy Practice 4:00-4:05 pm Dean Robert E. McGehee, Jr., Ph.D. Dean, UAMS Graduate School, Executive Director, Arkansas Biosciences Institute Professor, Department of Pediatrics/Neonatology, UAMS College of Medicine and Ark. Children's Hospital Keynote Presentation Artificial Intelligences and Machine Learning for Genomics and Biomarkers 4:05-4:55 pm Weida Tong, Ph.D. Director, Division of Bioinformatics and Biostatistics, National Center for Toxicological Research at US FDA 4:55-5:00 pm Break Session 1 Session Chair: Ujwani Nukahla, Graduate Student, University of Arkansas for Medical Sciences Edward Selvik, Graduate Student, University of Arkansas for Medical Sciences FDALabel Database on Amazon Cloud with Rich Drug Labeling Information to Advance the Application of Precision Medicine 5:00 – 5:20 pm Hong Fang, Ph.D. Senior Bioinformatician, Office of Scientific co-ordination, National Center for Toxicological Research at US FDA (Abstract no 41/ Page 63) Synthesis, In Vitro Stability And In vivo Pharmacokinetic Behavior of Opioid-Cannabinoid Codrugs as Potential Nociceptive and Neuropathic Pain Agents 5:20 – 5:35 pm Zaineb Albayati, Ph.D. Research Associate II, University of Arkansas for Medical Sciences (Abstract no 2/ Page24) Development and Validation of Estrogen Receptor Beta Binding Prediction Model Using Large Sets of Chemicals 5:35 – 5:50 pm Suguna Devi Sakkiah, Ph.D. Visiting Scientist, National Center for Toxicological Research at US FDA (Abstract no 38/ Page 60) 5 5:50 -7:30 pm Poster Session and Student-Faculty Mixer Day 2, Friday June 14, 2019 7:30-8:00 am Coffee and Light Breakfast 8:00-12:00 am Registration Sunrise Session Pharmacokinetics in Drug Development and Discovery 8:00-9:00 am Philip J. Breen, Ph.D. Professor, Collage of Pharmacy, University of Arkansas for Medical Sciences Keynote Presentation Biomarker Science in Monitoring Drug Safety and Disease State 9:00-9:50 am Vishal Vaidya, Ph.D. Director, Biomarker Analytics Global Lead at Pfizer 9:50- 10:00 am Break Session 2 Session Chair: Ting Li, Graduate Student, National Center for Toxicological Research at US FDA David Mery, Graduate Student, University of Arkansas for Medical Sciences Featured Speaker Discovering drugs from nature: Accurate calculations and experiments to help determine the structure and properties of complex, flexible natural products. 10:00-10:30 am Robert Doerksen, Ph.D. Associate Dean of the Graduate School, Associate Professor of Medicinal Chemistry, Research Associate Professor in the Research Institute of Pharmaceutical Sciences, University of Mississippi Drug Repositioning for Noonan and LEOPARD Syndrome by Integrating Transcriptomics and Structure-based Approach 10:30-10:45 am Liyuan Zhu Graduate Student, National Center for Toxicological Research (Abstract no 40/ Page 62) Activation of Metabolic Space of Cystobacter Ferrugineus by Intercepting 10:45-11:00 am Shukria Akbar Graduate Student, University of Mississippi (Abstract no 29/ Page 51) Bioactivation of Halogenated Aromatic Drugs as A Precursor to Drug-Induced Hepatotoxicity 11:00-11:15 am Mary "Allie" Davis Graduate Student, Collage of Pharmacology and Toxicology, University of Arkansas for Medical Sciences (Abstract no 12/ Page 34) 6 The Role of Non-Coding RNA and mRNA Interations In Regulation of Drug Metabolizing Enzymes and Hepatotoxicity 11:15 – 11:30 pm Dongying Li, Ph.D. Post-Doctoral Fellow, University of Arkansas for Medical Sciences (Abstract no 34/ Page 56) 11:30 - 12:15 pm Lunch Session 3 Session Chair: Phuc Tran, Graduate Student, University of Arkansas for Medical Sciences Cord Carter, Graduate Student, University of Arkansas for Medical Sciences Featured Speaker Plasma exosomal CYP2E1 and its role in neurotoxicity 12:15 – 12:45 pm Santosh Kumar, Ph.D. Associate Professor, Pharmaceutical Sciences, University of Tennessee Health Science Center 12:45 – 1:00 pm Break Keynote Presentation Improving Prediction: What Research Is Necessary to Enhance Drug Safety? 1:00-1:45 pm William Slikker, Jr., Ph.D. Director, National Center for Toxicological Research at US FDA Identification of Novel Drugs for Treatment of Neurodegenerative Diseases by Quantitative Structure-Activity Relationship Approach 1:45-2:15 pm Samuel Kakraba Graduate Student, University of Arkansas for Medical Sciences (Abstract no 33/ Page 55) Robust Liquid Chromatography Tandem Mass Spectrometry Method to Simultaneously Quantify Phytosterols and Tocopherols Entrapped in Liposomal Formulation 2:15-3:00 pm Asmita Poudel Graduate Student, University of Saskatchewan, Canada (Abstract no 36/ Page 58) 3:00 – 3:15 pm Break Session 4 Session Chair: Skylar Connor, Graduate Student, University of Arkansas for Medical Sciences Taylor Connor, Graduate Student, University of Arkansas for Medical Sciences Featured Speaker What Can We Learn from Millions of Viral Genome Sequences? 3:15 -3:45 pm David Ussery, Ph.D. Professor, Biomedical Informatics Department, Physiology and Biophysics Department in the College of Medicine, University of Arkansas for Medical Sciences, Director, Arkansas Center for Ecological and Genomic Medicine (ArC-GEM) 7 Anti-Metastatic Capacities of Melatonin Receptor Agonists on Different Breast Cancer Cell Lines 3:45-4:00 pm Alev Tascioglu Aliyev Graduate Student, University of Arkansas for Medical Sciences (Abstract no 31/ Page 53) Insights into The Dfg-Flip and Mechanism of Activation of Aurora Kinase B by Metadynamics 4:00-4:15 pm Naga Rajiv Lakkaniga Graduate Student, University of Arkansas for Medical Sciences (Abstract no 16/ Page 38) Develop a Database of Herbal/ Dietary Supplements (HDS) Hepatotoxicity for Supporting the FDA’s New Efforts to Strengthen Regulation of HDS Products 4:15-4:35 pm Minjun Chen, Ph.D. Principal Investigator, Division of Bioinformatics, National Center for Toxicological Research at US FDA (Abstract no 39/ Page 61) 4:35-4:45 pm Break Panel Discussion Drug Discovery and Development in an Academic Environment Moderator: Shraddha Thakkar Ph.D., Principal Investigator, National Center for Toxicological Research, at US FDA Panelist: 4:45-5:45 pm Cesar Compadre Ph.D., Professor, University of Arkansas for Medical Sciences James Sumpter Ph.D., Managing Director at Caerul LLC Darin Jones Ph.D., Associate Professor, University of Arkansas for Medical Sciences Pravin R. Chaturvedi, Ph.D., CEO, Oceanyx Pharmaceuticals Weida Tong, Ph.D., Director, Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, at US FDA Day 3, Saturday June 15, 2019 7:30-8:00 am Coffee and Light Breakfast Sunrise Session Career Development 8:00-9:00 am (CV & LinkedIn Tips & Help, Post Doctorial Panels) (Faculty only Round Table) Keynote Presentation Practical Considerations in Development of New Drugs from Natural Product Initiatives 9:00-9:45 am Pravin Chaturvedi, Ph.D. CEO, Oceanyx Pharmaceuticals 9:45-10:00 am Break Session 5 Session Chair: Julia Tobacyk, Graduate Student, University of Arkansas for Medical Sciences 8 Featured Speaker The olive-based (-)-oleocanthal as a novel target-based breast cancer recurrence inhibitor 10:00-10:30 am Khalid El Sayed, Ph.D. Professor of Medicinal and Natural Products, Chemistry, University of Louisiana, Monaro Featured Speaker Evidence for a novel mechanism of action for anticancer 1,2,4-thiadiazolidin-3,5-dione
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