Life Sciences Overview 2008.FH11

STATE OF ISRAEL Ministry of Industry Trade and Labor Foreign Trade Administration Investment Promotion Center Inspiration Invention Innovation Life Sciences in Israel www.investinisrael.gov.il Table of Contents Israel: A Powerhouse of Opportunities......................................... 2 Israel Life Science Sectors............................................................. 3 Medical Devices..........................................................................3 BioPharmaceutical...................................................................... 7 Israels Biomedical Engineering - Spotlight on Stem Cell Research......................................................1 1 Israels Life Sciences Competitive Edge....................................... 15 Government Support.................................................................. 19 2 Life Sciences in Israel Why Israel's Life Sciences More than 900 Life Sciences Companies - Biopharma and Israel: A Powerhouse of Opportunities Medical Devices Over a 1/3 of LS Start-Ups Over the last decade, Israel has introduced a wealth of groundbreaking already generate revenue and valuable innovations in Life Sciences. Israels Life Sciences sector is supported by a strong foundation of academic excellence, including Source of numerous some of the world's leading research institutes, renowned R&D facilities blockbuster drugs such as and cutting-edge medical centers. Bolstered by a highly skilled workforce, Copaxone and Rebif generating over $5B in annual a flourishing high-tech environment, and an entrepreneurial spirit, Israeli sales companies have been joined by leading multinationals in making Israel a recognized force in the Life Sciences industry worldwide. Global giants, 1st in the world in availability including J&J, Perrigo, GE Healthcare, Phillips Medical, together with local of Engineers and Scientists companies such as Teva, itself now a multi-national company, Given (IMD 2007) Imaging, Insightec, Medinol, Disc-o-tech, Brainstorm and others have 1st in the world for Medical been continuously developing and marketing life-changing medical Device Patents per capita, 4th breakthroughs and innovations. for Bio-Pharma (US Patents Office) 6th in in the no. of scientific Prior to 1996, Israel was home to 186 Life Sciences companies. By 2008, publications per capita (E&Ys this number has passed 900. With 50-60 new companies being formed Beyond Borders 2007 analyzed by each year, 41% of all Life Sciences companies operating in Israel today MOITAL) were established during the last 5 years. In a relatively short period of Pioneers in Stem Cell Research time, an astounding 34% of these companies has already begun to & Therapeutics generate revenue, demonstrating that Israel has crossed the threshold Extensive International R&D from an attractive startup arena to a source of advanced commercially and Commercial Partnerships viable and promising businesses. The bridge connecting excellent science World renown academic to revenue generating companies has been built. A rich pipeline of seed research institutes such as companies promises to perpetuate current growth. The Technion and The Weizmann Institute 2nd in Europe in no. per capita of private biotech companies Professors Aaron Ciechanover and Avram Hershko products in pipeline (E&Ys Beyond Borders 2007 analyzed by of the Technion received the Nobel Prize for MOITAL) Chemistry in 2004 for their discovery of Ubiquitin- Unique financing tools for mediated protein degradation, leading to breakthroughs in the young projects and companies understanding and treatment of diseases such as Cancer, Alzheimers, Parkinsons disease and Cystic Fibrosis. 3 Israeli Life Sciences Sectors Today, Israel is home to a thriving Life Sciences industry in which the Life Sciences Companies major sectors are Medical Devices and BioPharma. Over the last 5 years, by Sector more companies were established in life sciences than in any other sector, with the rate of investments (including Angels, Venture Capital Agrobiotechnology 4% and Corporate) greatly outpacing all other segments of the economy. Other Pharmaceuticals 4% Health IT 12% 6% Medical Devices In the area of Medical Devices, Israels scientists and engineers have integrated advanced technologies in electronics, communications, and electro-optics in the development of world-class innovations in digital Biotechnology Medical Devices imaging, medical lasers, electro-medical devices, telemedicine, surgical 20% 54% equipment, diagnostic kits, and rehabilitation equipment. According to Source: ILSI 2006 the US Patent Office, Israel has the highest rate of registered medical device patents per capita in the world, with cutting edge innovations such as ingestible cameras, portable cardiac ultrasound systems and instant CT scanners helping to significantly improve global health and well being while at the same time, creating significant investor value. Israels Medical Device The largest sub sector in the medical device arena is therapeutic devices, Companies - Sub Sectors both implantable and disposable. Monitoring 6% Diagnostic Medical Other 14% Many of Israels innovations in Medical Devices have already been adopted Equipment 16% 10% worldwide. Others have been more recently introduced and are undergoing clinical trials both in Israel and other countries. The list of advances and breakthroughs cuts across many sub sectors in the Medical Devices arena. Imaging Drug Disposable & 6% Delivery Implantable 4% 41% Source: ILSI Database - 2006 4 Life Sciences in Israel Noted Israeli Breakthroughs in The Medical Devices Field The Medical Imaging Design Excellence The Pillcam, the first miniature ingested camera which diagnoses and Award was photographs abnormalities in the gastrointestinal tract were introduced presented to NESS by Given Imaging (NASDAQ: GIVN). Neuromuscular Electrical A comprehensive picture of a patient can be taken in seconds instead Stimulation Systems for its of minutes with the introduction of the Philips Brilliance CT scanner, L300 leg neuroprosthesis, a developed in Israel. noninvasive device which delivers electrical stimulation to Disposable and Implantable nerves and muscles in the leg, improving the walking ability of The closed cell stent design which facilitates blood flow to the heart those suffering from foot drop was pioneered and developed by Medinol in the early 1990's. Medinol associated with central nervous continues to introduce additional innovations in the field of heart system injury or disease. catheterization. A highly advanced and cost efficient surgical sealant or "biological glue", Quixil, which facilitates haemostasis and reduces operative and post- operative bleeding, was developed by Omrix Biopharmaceuticals. Other Medical Device Technologies ExAblate 2000, a non-invasive surgery which uses MR guided focused ultrasound to treat uterine fibroids was developed by Insightec. A minimally invasive cryotherapy solution - the freezing and ablating of benign and cancerous tissues, thus enhancing a patient's recovery process and comfort, was devised by Galil Medical. 5 Cutting Edge R&D Neurosonix As a substitute for biopsies, Incure is completing the development of received the a kit that can detect cancerous cells in a simple blood test. European Association of Cardiac-Thoracic Surgery A treatment using a breathing instrument to determine the patients Techno-College Innovation liver function has been introduced by Exalenz. The device has already Award for its EmBlocker, which been successfully tested on Hepatitis C and NAFLD (Non-Alcoholic uses ultrasonic energy to non- Fatty Liver Disease) patients and is expected to be soon on the market. invasively divert emboli flow away from the cerebral arteries The Accordion Pill, a new approach to the slow release of medication, in order to reduce the risk of which provides significant benefits to both patients and drug post-operative brain injury and companies, was developed by Intec Pharma. can provide protection against cerebral embolism during open Microneedle based systems for the painless intradermal delivery of heart procedures. drugs was implemented by NanoPass. NanoPass collaborated with GlaxoSmithKline on optimization of its platform for vaccine delivery. A live-tissue memory and processing chip was created at Tel Aviv University to demonstrate how our brain learns and stores information, an important advancement toward sophisticated artificial intelligence solutions. This chip was cited by Scientific American Magazine as one of the 50 most significant scientific breakthroughs of 2007. 6 Life Sciences in Israel Biopharmaceuticals Backed by outstanding academic and research institutes (ranked # 4 in Israels Biotech Companies - the world by WEF 2006-7), Israel is recognized as one of the world's Subsectors leaders in biopharmaceuticals, comprised of Israeli biotech and pharmaceutical companies engaged in drug discovery, stem cell research, Pharmaceuticals, Biopharmaceuticals, immunology and more. Israel's pharmaceutics and biotechology industries Biogenerics have benefited greatly from each other. Biotechnology serves as a key 5% Tissue Engineering & Cell Therapy driver for growth in the entire pharmaceutical industry: introducing new 16% Research and improved products, innovative technologies, extending patent life, Equipment Antibody, & Tools Immunotherapy adding revenue streams and shortening the time to FDA approval and Industrial 9% & Vaccines 7% the market. Israel is a global leader in the number of new patents filed

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