DOCSLIB.ORG

Liquid Photonic Crystal Detection Reagent for Reliable Sensing of Cu2+ in Water† Cite This: RSC Adv., 2020, 10,10972 Yixin Zhang and Jianping Ge *

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Liquid Photonic Crystal Detection Reagent for Reliable Sensing of Cu2+ in Water† Cite This: RSC Adv., 2020, 10,10972 Yixin Zhang and Jianping Ge * RSC Advances View Article Online PAPER View Journal | View Issue Liquid photonic crystal detection reagent for reliable sensing of Cu2+ in water† Cite this: RSC Adv., 2020, 10,10972 Yixin Zhang and Jianping Ge * A traditional hydrogel photonic crystal sensor is prepared by multiple steps, including colloidal assembly, polymerization, and recognition group modification, and its measurement repeatability is a challenge due to the inevitable deviations in sensor fabrication and application. In this work, a salicylic acid- containing “SiO2/propylene carbonate” liquid photonic crystal (Sal-LPC), as a new photonic sensing material, was developed to demonstrate reliable measurement of Cu2+ in water. When the Sal-LPC reagent was mixed with the test sample, the Cu2+ promoted the release of H+ from Sal and shrank the photonic crystal lattice, so that the Cu2+ concentration could be determined by the reflection blueshift of liquid PC. The Sal-LPC reagent showed a stronger response to Cu2+ than to other cations, and its sensitivity and measurement range could be optimized by the particle fraction and Sal dosage. Compared to traditional PC hydrogel sensors, the liquid PC reagent was composed of colloidal particles Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Received 2nd February 2020 and responsive species, which required no strict control in synthesis. More importantly, the optical Accepted 26th February 2020 response of the liquid PC reagent was scarcely affected by changes in synthesis, storage, or application, DOI: 10.1039/d0ra01014f and it could interact with the analyte quickly and quantitatively, which ensured accurate and repeatable rsc.li/rsc-advances measurement in either chemical analysis or environmental monitoring. Introduction porosity,13 magnetic elds,14–16 humidity,17–20 pH value,21,22 ions,23–26 vapor,27–29 microbes,30 and biomolecules.31–34 Such Photonic crystals (PCs) are periodic dielectric structures which enthusiasm should continue in the coming years, considering This article is licensed under a forbid the propagation of electromagnetic waves of certain the practical applications of these materials. frequency ranges. Once an external light source is projected Among all PC sensors, a chemical sensor for the detection of onto the PC, it shows characteristic reection, transmission, ions and molecules has gained a lot of attention, not only – Open Access Article. Published on 17 March 2020. Downloaded 9/23/2021 3:41:31 PM. and structural colors due to the modulation of light by the because it was developed very early35 37 and studied extensively photonic bandgap. A responsive photonic crystal (RPC) is one in history, but also because it was considered to be a prototype kind of smart PC material, which changes periodic dielectric for other PC sensors. Generally, a PC-based ion sensor was structures and thereby optical properties along with a change in composed of colloidal crystals embedded in hydrogels or external stimuli.1–5 Due to the intrinsic relationship between inverse opaline hydrogels, whose polymer networks were cova- external stimuli, PC structure, and optical signals, which form lently anchored with the recognition groups. Once the target a basic framework for a sensing mechanism, these responsive ions entered the PC gels, they would react with the recognition photonic crystals have been broadly investigated as PC sensors. group, shrink/expand the gel, and eventually lead to a change in Many chemical or physical parameters in which people are reection signals. For example, Asher et al. developed an 8- interested have been measured, either qualitatively through hydroxyquinoline modied PC hydrogel for the detection of color changes or quantitatively by shisinreection peaks. In Cu2+ in drinking water.38 As the Cu2+ concentration increased, the past decade, researchers have developed various PC sensors the binary coordination complex between Cu2+ and 8-hydrox- to detect temperature,6–8 mechanical force,9–11 viscosity,12 yquinoline changed to a univalent complex and the hydrogel swelled so that the Cu2+ concentration could be measured by the redshi of the reection peak. In another instance, a crown School of Chemistry and Molecular Engineering, Shanghai Key Laboratory of Green ether graed PC hydrogel was reported to detect the smallest Chemistry and Chemical Processes, East China Normal University, Shanghai metal ion Be2+ based on the selective chelation of crown ether 200062, China. E-mail: [email protected]; Tel: +86-21-62224356 and cations.39 The Be2+ concentration could be measured † Electronic supplementary information (ESI) available: OM and SEM images of liquid PCs, inuence of Cu2+ or Sal upon reection signals, reection blueshi according to the re ection redshi of the PC hydrogel, as the of liquid PCs with different particle volume fraction, reproducibility in chelation would promote the swelling of the hydrogel and measurements of reection blueshi, the composition of all liquid PCs in this thereby the expansion of the PC lattice. Although polymeric PC work, the formation constant of metal–salicylic acid complex, and the based chemical sensors had already been demonstrated disassociation of Sal promoted by metal cation. See DOI: 10.1039/d0ra01014f 10972 | RSC Adv.,2020,10,10972–10979 This journal is © The Royal Society of Chemistry 2020 View Article Online Paper RSC Advances through the detection of different ions and molecules, there (Fe(NO3)3$9H2O) were all purchased from Sigma-Aldrich Co. were still disadvantages for the traditional PC sensor. The Ltd. All chemicals were used as received without further fabrication of PC hydrogel sensors usually required multiple treatment. steps, including colloidal assembly, hydrogel polymerization, and recognition group modication. The change in optical Preparation of Sal-LPC detection reagent signals was affected by the loading amount of recognition Firstly, monodispersed SiO colloidal particles were prepared by group, the xation of PC lm on the substrate, and even the 2 a modied Stober¨ method. Aer washing with ethanol three testing position. Therefore, precise and repeatable measure- times, SiO colloidal particles (0.025 cm3) were dispersed in ment results could be a challenge for the commercialization of 2 ethanol (1 mL) to form a stable colloidal dispersion. Propylene these traditional sensors. In previous work, most studies carbonate (75 mL) and the ethanol solution of salicylic acid focused on the sensitivity and measurement range, but very (0.5 mM, 10 mL) were then added to the above solution and little attention was paid to repeatability among individual mixed with it by a vortex mixer. Subsequently, the mixture was sensors. transferred to an oven at 90 C for 2 h, where ethanol was In this work, we would like to demonstrate a new kind of evaporated to produce a salicylic acid-containing SiO /PC liquid liquid PC based chemical sensor through its detection of Cu2+ 2 photonic crystal (Sal-LPC) detection reagent with a total volume in water. A liquid PC was prepared by the thermal evaporation of 100 mL. The preparations of Sal-LPC reagents with different induced supersaturation of colloidal particles followed by their Sal concentrations, particle volume fractions, and particle self-assembly in solution.40 Compared to traditional methods, diameters were the same as in the above procedures, except for this was an efficient way to obtain highly crystalline colloidal the indicated changes made in preparation. PCs at a large scale, which guarantees their application in related devices. Liquid PCs have a vast potential to serve as 2+ detection reagents since their optical signals are sensitive to Working curves for measurement of Cu concentration 2+ Creative Commons Attribution-NonCommercial 3.0 Unported Licence. many physicochemical parameters in solution, including The working curve for the measurement of Cu concentration particle volume fraction, pH value, ionic strength, solvent (CCu2+) was established by measuring the reection wavelength polarity, and viscosity. Here, a salicylic acid-containing “SiO2/ change of the liquid PC reagent when it was mixed with an propylene carbonate” liquid photonic crystal (Sal-LPC) is an aqueous solution of Cu2+ at different concentrations. In accurately sensitive reagent to Cu2+ concentration, because the a typical test, the Sal-LPC reagent (100 mL) was mixed with Cu2+ promotes the release of H+ from Sal and shrinks the deionized water (10 mL) to form a homogenous suspension. The photonic crystal lattice so that the Cu2+ concentration can be Sal-LPC reagent with deionized water was kept for 5 min to determined by the reection blueshi of the liquid PC. The Sal- ensure complete interaction. Some of the above mixed solution LPC reagent had a stronger response to Cu2+ than to other (5 mL) was taken out and sandwiched between two glass slides to This article is licensed under a cations, and its measurement range could be optimized by the form a liquid lm with a thickness of 100 mm. Aer being kept Sal dosage. Compared to traditional PC hydrogel sensors, the for 5 min, liquid colloidal PC spontaneously precipitated from liquid PC reagent was composed of a mixed solution of colloidal the liquid lm and its reection wavelength was measured and l m Open Access Article. Published on 17 March 2020. Downloaded 9/23/2021 3:41:31 PM. particles and responsive species, which required no strict recorded as 0. On the other hand, the Sal-LPC reagent (100 L) control over synthesis and modication of photonic crystals. was mixed with an aqueous solution of Cu2+ (10 mL) to form More importantly, the optical response of the liquid PC reagent another homogenous suspension and a new liquid PC, whose was scarcely affected by changes in synthesis, storage, or reection wavelength was measured to be l0. Then, the reec- 0 application, and it could interact with the analyte quickly and tion wavelength change (Dl ¼ l À l0) caused by the introduc- quantitatively, all of which ensured an accurate and repeatable tion of Cu2+ could be determined according to the two response for this new sensing material.
Load more

Recommended publications
  • Two-Dimensional Photonic Crystal Based Sensor for Pressure Sensing
    PHOTONIC SENSORS / Vol. 4, No. 3, 2014: 248–253 Two-Dimensional Photonic Crystal Based Sensor for Pressure Sensing * Krishnan VIJAYA SHANTHI and Savarimuthu ROBINSON PG Scholar, Communication Systems, Mount Zion College of Engineering and Technology, Pudukkottai-622507, Tamil Nadu, India *Corresponding author: Krishnan VIJAYA SHANTHI Email: [email protected] Abstract: In this paper, a two-dimensional photonic crystal (2DPC) based pressure sensor is proposed and designed, and the sensing characteristics such as the sensitivity and dynamic range are analyzed over the range of pressure from 0 GPa to 7 GPa. The sensor is based on 2DPC with the square array of silicon rods surrounded by air. The sensor consists of two photonic crystal quasi waveguides and L3 defect. The L3 defect is placed in between two waveguides and is formed by modifying the radius of three Si rods. It is noticed that through simulation, the resonant wavelength of the sensor is shifted linearly towards the higher wavelength region while increasing the applied pressure level. The achieved sensitivity and dynamic range of the sensor is 2 nm/GPa and 7 Gpa, respectively. Keywords: Photonic crystal, waveguide, photonic band gap, optical sensor, FDTD method pressure sensor Citation: Krishnan VIJAYA SHANTHI and Savarimuthu ROBINSON, “Two-Dimensional Photonic Crystal Based Sensor for Pressure Sensing,” Photonic Sensors, 2014, 4(3): 248–253. one-dimensional photonic crystal (1DPCs), 1. Introduction two-dimensional photonic crystals (2DPCs), and In 1987, Eli Yablonovitch and Sajeev John three-dimensional photonic crystals (3DPCs). The published their research work on photonic crystals, sensor, based on 2DPCs, is receiving increasing predicting the existence of the photonic band gap as attention from the scientific community because it well as the potential for inhibiting spontaneous has relatively simple structure, small size, better emission and localizing light within defects in a confinement of light, accurate band gap calculation, and periodic lattice of appropriate dimensions [1].
    [Show full text]
  • Photonic Crystal Sensors Based on Porous Silicon
    Sensors 2013, 13, 4694-4713; doi:10.3390/s130404694 OPEN ACCESS sensors ISSN 1424-8220 www.mdpi.com/journal/sensors Review Photonic Crystal Sensors Based on Porous Silicon Claudia Pacholski Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, Stuttgart 70569, Germany; E-Mail: [email protected]; Tel.: +49-711-689-3620; Fax: +491-711-689-3612 Received: 8 February 2013; in revised form: 26 March 2013 / Accepted: 3 April 2013 / Published: 9 April 2013 Abstract: Porous silicon has been established as an excellent sensing platform for the optical detection of hazardous chemicals and biomolecular interactions such as DNA hybridization, antigen/antibody binding, and enzymatic reactions. Its porous nature provides a high surface area within a small volume, which can be easily controlled by changing the pore sizes. As the porosity and consequently the refractive index of an etched porous silicon layer depends on the electrochemial etching conditions photonic crystals composed of multilayered porous silicon films with well-resolved and narrow optical reflectivity features can easily be obtained. The prominent optical response of the photonic crystal decreases the detection limit and therefore increases the sensitivity of porous silicon sensors in comparison to sensors utilizing Fabry-Pérot based optical transduction. Development of porous silicon photonic crystal sensors which allow for the detection of analytes by the naked eye using a simple color change or the fabrication of stacked porous silicon photonic crystals showing two distinct optical features which can be utilized for the discrimination of analytes emphasize its high application potential. Keywords: photonic crystal; porous silicon; sensor 1.
    [Show full text]
  • Silicon Photonic Crystal Microarrays for High Throughput Label-Free
    Invited Paper Silicon photonic crystal microarrays for high throughput label-free detection of lung cancer cell line lysates with sensitivity and specificity Swapnajit Chakravartya, Wei-Cheng Laib, Yi Zoub, Robert M. Gemmillc, Ray T. Chen*a,b, aOmega Optics Inc., 10306 Sausalito Drive, Austin, TX, USA 78759; bDept. of Electrical and Computer Engineering, University of Texas, 10100 Burnet Road Bldg. 160, Austin, TX USA 78758; cMedical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425; ABSTRACT Detection of biomolecules on microarrays based on label-free on-chip optical biosensors is very attractive since this format avoids complex chemistries caused by steric hindrance of labels. Application areas include the detection of cancers and allergens, and food-borne pathogens to name a few. We have demonstrated photonic crystal microcavity biosensors with high sensitivity down to 1pM concentrations (67pg/ml). High sensitivities were achieved by slow light engineering which reduced the radiation loss and increased the stored energy in the photonic crystal microcavity resonance mode. Resonances with high quality factor Q~26,760 in liquid ambient, coupled with larger optical mode volumes allowed enhanced interaction with the analyte biomolecules which resulted in sensitivities down to 10 cells per micro-liter to lung cancer cell lysates. The specificity of detection was ensured by multiplexed detections from multiple photonic crystal microcavities arrayed on the arms of a multimode interference power splitter. Specific binding interactions and control experiments were performed simultaneously at the same instant of time with the same 60 micro- liter sample volume. Specificity is further ensured by sandwich assay methods in the multiplexed experiment.
    [Show full text]
  • Development of 2-Dimensional Photonic Crystal Sensors and Pure Protein Organogel
    Title Page Development of 2-Dimensional Photonic Crystal Sensors and Pure Protein Organogel Sensing and Biocatalytic Materials by Natasha Lynn Smith B.S. West Virginia University, 2009 Submitted to the Graduate Faculty of the Dietrich School of Arts and Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Pittsburgh 2019 Committee Membership Page UNIVERSITY OF PITTSBURGH DIETRICH SCHOOL OF ARTS AND SCIENCES This dissertation was presented by Natasha Lynn Smith It was defended on August 12, 2019 and approved by Dr. Sean Garrett-Roe, Associate Professor, Department of Chemistry, University of Pittsburgh Dr. Seth Horne, Associate Professor, Department of Chemistry, University of Pittsburgh Dr. Sachin Velankar, Associate Professor, Mechanical Engineering and Material Science, University of Pittsburgh Dissertation Director: Dr. Sanford A. Asher, Distinguished Professor of Chemistry, Department of Chemistry, University of Pittsburgh ii Copyright © by Natasha Lynn Smith 2019 Abstract iii Development of 2-Dimensional Photonic Crystal Sensors and Pure Protein Organogel Sensing and Biocatalytic Materials Natasha L. Smith, PhD University of Pittsburgh, 2019 We developed responsive hydrogels, organogels, and ionogels for chemical sensing and catalysis applications. Gels have two components, polymer networks and solvent mobile phases. Hydrogels contain an aqueous mobile phase; organogels an organic solvent; and ionogels an ionic liquid. Different solvent types were required to target different applications, e.g. gas sensing requires solvents that resist evaporation. Colorimetric chemical sensors utilize our 2-Dimensional Photonic Crystals (2DPC) technology. 2DPC are arrays of self-assembled polystyrene nanoparticles that have close-packed, hexagonal crystal structures. 2DPC diffract wavelengths of light into discrete angles according to the 2D Bragg equation.
    [Show full text]
  • Molecular Imprinted Photonic Crystal for Sensing of Biomolecules
    Mol. Impr. 2016; 4: 1–12 Review Open Access Wei Chen, Zihui Meng*, Min Xue, Kenneth J Shea Molecular imprinted photonic crystal for sensing of biomolecules DOI 10.1515/molim-2016-0001 environmental monitoring and food quality control. Thus, Received December 8, 2015; accepted January 29, 2016 different biochemical sensors have been developed to detect biologically active molecules and determine the Abstract: Molecularly imprinted polymers (MIPs) concentration of these molecules. Due to the structure are highly cross-linked polymers with high binding complexity and large size of the biomolecules, it is a big capacity and selectivity to the target molecules. MIPs challenge to develop a good biosensor. An ideal biosensor become increasingly important because of the potential should possess the advantages of high specificity, applications in drug delivery, purification and separation. sensitivity, quick response rate as well as low cost. Thus, In spite of the tremendous progress that has been made in developing new technology for biomolecules detection the molecular imprinting field, many challenges remain has attracted much attention. [2-5] to be addressed, especially in transforming the binding The common detection methods include high event into a detectable optical signal. The combination performance liquid chromatography (HPLC) [6-7], mass of photonic crystal and molecular imprinting technique spectrometry (MS) [8-9], fluorescence [10-11], surface- is becoming a popular research idea. Compared to the enhanced Raman scattering (SERS) [12-14], enzyme- conventional MIPs, the molecularly imprinted photonic linked immunosorbent assay [15-16] and immunoassays crystal sensors (MIPCB) have the advantage of directly [17-18]. Each of these methods suffers from one or more convert the molecule recognition process into optical disadvantages, such as require complicated screening and signal.
    [Show full text]
  • Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers
    chemosensors Review Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers Michailia Angelopoulou, Sotirios Kakabakos and Panagiota Petrou * Immunoassay/Immunosensors Lab, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, NCSR “Demokritos”, 15310 Athens, Greece; [email protected] (M.A.); [email protected] (S.K.) * Correspondence: [email protected]; Tel.: +30-210-650-3819 Received: 13 September 2018; Accepted: 6 November 2018; Published: 12 November 2018 Abstract: The article reviews the current status of label-free integrated optical biosensors focusing on the evolution over the years of their analytical performance. At first, a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical biosensors, including sensors based on surface plasmon resonance (SPR), grating couplers, photonic crystals, ring resonators, and interferometric transducers. For each type of biosensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free optical biosensors is provided. Keywords: integrated optical sensors; monolithic integration; broad-band interferometers; label-free; multiplexed detection; on-site determinations 1. Introduction Starting more than 50 years ago from the report of Clark and Lyons [1], biosensors have been the subject of intensive research efforts, but also of numerous attempts of commercial exploitation aiming to overcome the limitations of classical analytical systems and provide solutions for on-site determinations. The research effort has generated over the years an enormous variety of biosensors considering the multiple variations of the more popular ones, such potentiometric or the surface plasmon resonance based sensors [2].
    [Show full text]
  • Photonic Crystal Based Sensor for Organic Solvents and for Solvent-Water Mixtures
    Sensors 2012, 12, 16954-16963; doi:10.3390/s121216954 OPEN ACCESS sensors ISSN 1424-8220 www.mdpi.com/journal/sensors Article Photonic Crystal Based Sensor for Organic Solvents and for Solvent-Water Mixtures Christoph Fenzl, Thomas Hirsch and Otto S. Wolfbeis * Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040 Regensburg, Germany; E-Mails: [email protected] (C.F.); [email protected] (T.H.) * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +49-941-943-4065; Fax: +49-941-943-4064. Received: 25 October 2012; in revised form: 28 November 2012 / Accepted: 5 December 2012 / Published: 12 December 2012 Abstract: Monodisperse polystyrene nanoparticles with a diameter of 173 nm were incorporated into a polydimethylsiloxane matrix where they display an iridescent color that can be attributed to the photonic crystal effect. The film is of violet color if placed in plain water, but turns to red in the presence of the non-polar solvent n-hexane. Several solvents were studied in some detail. We show that such films are capable of monitoring the water content of ethanol/water mixtures, where only 1% (v/v) of water leads to a shift of the peak wavelength of reflected light by 5 nm. The method also can be applied to determine, both visually and instrumentally, the fraction of methanol in ethanol/methanol mixtures. Here, a fraction of 1% of methanol (v/v) results in a wavelength shift of 2 nm. The reflected wavelength is not influenced by temperature changes nor impeded by photobleaching. The signal changes are fully reversible and response times are <1 s.
    [Show full text]
  • Plasma Cell Sensor Using Photonic Crystal Cavity
    Plasma Cell Sensor Using Photonic Crystal Cavity Zaky Zaky ( [email protected] ) Beni Suef University Faculty of Science https://orcid.org/0000-0002-8300-7755 B. Moustafa Beni Suef University Faculty of Science Arafa H. Aly Beni Suef University Faculty of Science Research Article Keywords: biosensor, photonic crystal, plasma cells, blood components, transfer matrix method (TMM) Posted Date: June 22nd, 2021 DOI: https://doi.org/10.21203/rs.3.rs-412787/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Plasma cell sensor using photonic crystal cavity Zaky A. Zaky*, Basma Moustafa and Arafa H. Aly TH-PPM Group, Physics Department, Faculty of Sciences, Beni-Suef University, Egypt * Corresponding author, Zaky A. Zaky; [email protected] & [email protected] Abstract The performance of one-dimensional photonic crystal for plasma cell application is studied theoretically. The geometry of the structure can detect the change in the refractive index of the plasma cells in a sample that infiltrated through the defect layer. We have obtained a variation on the resonant peak positions using the analyte defect layer with different refractive indices. The defect peak of the optimized structure is red-shifted from 2195 nm to 2322nm when the refractive index of the defect layer changes from 1.3246 to 1.3634. This indicates a high sensitivity of the device (S=3300 nm/RIU) as well as a high Q-factor (Q=103). The proposed sensor has a great potential for biosensing applications and the detection of convalescent plasma.
    [Show full text]
  • The Use of Computational Methods for the Development of Molecularly
    polymers Review Review TheThe UseUse ofof ComputationalComputational MethodsMethods forfor thethe DevelopmentDevelopment of ofMolecularly Molecularly Imprinted Imprinted Polymers Polymers IanIan A.A. NichollsNicholls **, Kerstin, Kerstin Golker, Golker, Gustaf Gustaf D. D. Olsson, Olsson Subramanian, Subramanian Suriyanarayanan Suriyanarayanan and Jesper G. Wiklander and Jesper G. Wiklander Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, BioorganicDepartment & of Biophysical ChemistryChemistry & Biomedical Laboratory, Sciences, Linnaeus Linnaeus University University, Centre SE-391 for 82 Biomaterials Kalmar, Sweden Chemistry,; [email protected] of Chemistry (K.G.); & [email protected] Sciences, Linnaeus (G.D.O.); University,[email protected] SE-391 (S.S.); 82 Kalmar, Sweden; [email protected]@lnu.se (K.G.); (J.G.W.) [email protected] (G.D.O.); [email protected] (S.S.); [email protected] (J.G.W.) ** Correspondence:Correspondence: [email protected] [email protected] Abstract:Abstract: RecentRecent yearsyears have have witnessed witnessed a dramatica dramatic increase increase in thein the use use of theoretical of theoretical and computationaland computa- approachestional approaches in the studyin the andstudy development and development of molecular of molecular imprinting imprinting systems. systems. These toolsThese are tools being are usedbeing toused either to either improve improve understanding understanding of the of mechanismsthe
    [Show full text]
  • Photonic Crystal Based Biosensor for the Detection of Glucose Concentration in Urine Savarimuthu ROBINSON* and Nagaraj DHANLAKSMI
    PHOTONIC SENSORS Photonic Crystal Based Biosensor for the Detection of Glucose Concentration in Urine Savarimuthu ROBINSON* and Nagaraj DHANLAKSMI Department of Electronics and Communication Engineering, Mount Zion College of Engineering and Technology, Pudukkottai, 622507, Tamil Nadu, India *Corresponding Author: Savarimuthu ROBINSON E-mail: [email protected] Abstract: Photonic sensing technology is a new and accurate measurement technology for bio-sensing applications. In this paper, a two-dimensional photonic crystal ring resonator based sensor is proposed and designed to detect the glucose concentration in urine over the range of 0 gm/dl-15 gm/dl. The proposed sensor is consisted of two inverted “L” waveguides and a ring resonator. If the glucose concentration in urine is varied, the refractive index of the urine is varied, which in turn the output response of sensor will be varied. By having the aforementioned principle, the glucose concentration in urine, glucose concentration in blood, albumin, urea, and bilirubin concentration in urine are predicted. The size of the proposed sensor is about 11.4 m×11.4 m, and the sensor can predict the result very accurately without any delay, hence, this attempt could be implemented for medical applications. Keywords: Biosensor; photonic crystal; refractive index; urine; glucose; urea Citation: Savarimuthu ROBINSON and Nagaraj DHANLAKSMI, “Photonic Crystal Based Biosensor for the Detection of Glucose Concentration in Urine,” Photonic Sensors, DOI: 10.1007/s13320-016-0347-3. 1. Introduction 40 mg/dl. High blood glucose level is known as “Hyperglycemia” and ranges from 270 mg/dl to After the invention of the optical sensor by Clark 360 mg/dl [2].
    [Show full text]
  • Photonic Crystals: Analysis, Design and Biochemical Sensing Applications Hamza Kurt
    Photonic crystals: Analysis, design and biochemical sensing applications A Thesis Presented to The Academic Faculty by Hamza Kurt In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the School of Electrical and Computer Engineering Georgia Institute of Technology August 2006 Copyright © 2006 by Hamza Kurt Photonic crystals: Analysis, design and biochemical sensing applications Approved by: Dr. Ali Adibi, Committee Chair Dr. Paul Voss School of ECE School of ECE Georgia Institute of Technology Georgia Institute of Technology Dr. David S. Citrin, Advisor Dr. Christopher Summers School of ECE School of MSE Georgia Institute of Technology Georgia Institute of Technology Dr. John Papapolymerou School of ECE Georgia Institute of Technology Date Approved: June 22, 2006 This dissertation is dedicated to my mother Seniye and my father Ali ACKNOWLEDGEMENTS The end of one journey means the beginning of another one. After two-year of study at the University of Southern California while exploring the west side of the US, I started my PhD program on the east side at Georgia Institute of Technology in 2002. During the last year of my study, I had a chance to move to the Georgia Tech Lorraine, France. Throughout all these years, I was lucky meeting with precious people; friends, instructors and advisors. It is impossible to mention all of the people whom I would like to thank but first I want to express my sincere gratitude towards my advisor, Prof. David S. Citrin, for making my study at Georgia Tech stimulating and enjoyable one while giving me the full freedom to explore this research topic.
    [Show full text]
  • Improving Photonic Crystal Enhanced Fluorescence and Label-Free Biosensor Performance
    EXTERNAL CAVITY LASER LABEL-FREE BIOSENSOR BY CHUN GE DISSERTATION Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Electrical and Computer Engineering in the Graduate College of the University of Illinois at Urbana-Champaign, 2013 Urbana, Illinois Doctoral Committee: Professor Brian T. Cunningham, Chair Professor J. Gary Eden Professor Kent D. Choquette Professor Paul J. Hergenrother ABSTRACT Utilizing a tunable photonic crystal resonant reflector as a mirror of an external cavity laser, we demonstrate a new type of label-free optical biosensor that achieves a high quality factor through the process of stimulated emission, while at the same time providing high sensitivity, large dynamic range and simple detection instrumentation. The photonic crystal is fabricated inexpensively from plastic materials, and its resonant wavelength is tuned by adsorption of biomolecules on its surface. Gain for the lasing process is provided by a semiconductor optical amplifier, resulting in a simple detection instrument that operates by normally incident noncontact illumination of the photonic crystal and direct back-reflection into the amplifier. We demonstrate single-mode, mode-hop-free, biomolecule-induced tuning of the continuous-wave laser wavelength. Because the approach incorporates external optical gain that is separate from the transducer, the device represents a significant advance over previous passive optical resonator biosensors and laser-based biosensors. ii ACKNOWLEDGMENTS My graduate study at University of Illinois is one of the most memorable periods of my life. I felt very fortunate to have learned from and worked with so many incredible people. First of all, I would like to thank my advisor Prof.
    [Show full text]