RESEARCH ARTICLE Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012 Loïc Epelboin1,2*, Renaud Blondé3, Abdourahim Chamouine4, Alexandra Chrisment4, Laure Diancourt5, Nicolas Villemant6, Agnès Atale4, Claire Cadix7, Valérie Caro5, Denis Malvy8, Louis Collet7 1 Department of Prevention, Actions and Public Health, Centre Hospitalier de Mayotte, Mamoudzou, Mayotte, 2 Infectious and Tropical Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana, 3 Intensive Care Unit, Centre Hospitalier de Mayotte, Mamoudzou, Mayotte, 4 Department of Pediatrics, Centre Hospitalier de Mayotte, Mamoudzou, Mayotte, 5 Institut Pasteur, Environment and Infectious Risks Research and Expertise Unit, Paris, France, 6 Geography Institute (UFR08)—Paris 1 Panthéon-Sorbonne University, Paris, France, 7 Medical Biology Laboratory, Centre Hospitalier de Mayotte, Mamoudzou, Mayotte, 8 Victor Segalen University, Bordeaux 2, Bordeaux, France *
[email protected] a11111 Abstract Introduction Human angiostrongyliasis (HA) is a neurological helminthic disease caused by the lung OPEN ACCESS worm Angiostrongylus cantonensis. It is suspected in the combination of travel or a resi- Citation: Epelboin L, Blondé R, Chamouine A, dence in an endemic area and eosinophilic meningitis. In Mayotte, an island in the Indian Chrisment A, Diancourt L, Villemant N, et al. (2016) Ocean, cases are rare but regular. The main objective of our study was to describe the epi- Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012. PLoS Negl Trop demiological and diagnosis clues of HA in Mayotte. The secondary objectives were to eval- Dis 10(5): e0004635. doi:10.1371/journal. uate the contribution of Real-Time Polymerase Chain Reaction (RT- PCR) for the diagnosis pntd.0004635 of HA, delineate the characteristics of the local transmission and ascertain the presence of Editor: Malcolm Jones, University of Queensland, A.