THROMBOSIS and THROMBOEMBOLISM 2020 Comprehensive Updates for Prevention, Diagnosis, Treatment Boston, MA

Earn up to 15.75 AMA PRA Category 1 Credits™ 15.75 ABIM MOC points 15.75 AAFP Prescribed credits 15.75 CNE contact hours

Education for PHYSICIANs, NPs, PAs

Oct 8–9 THROMBOSIS AND THROMBOEMBOLISM 2020 Comprehensive Updates for Prevention, Diagnosis, Treatment Boston, MA

This program is among the highest-rated Harvard Medical School CME Courses.

PREVENTION Guidance and state-of-the-art approaches to: • Acute coronary syndromes DETECTION • Dual antiplatelet therapy, new oral anticoagulants, DIAGNOSIS and interventional devices • Pulmonary embolism and DVT TREATMENT • LDL and triglyceride reduction DEVICES • Stroke prevention in atrial fibrillation PROCEDURES • Genetics, thrombosis, and personalized medicine

Samuel Z. Goldhaber, MD Register at Thrombosis.HMSCME.com Paul M Ridker, MD, MPH

This special program is offered once every two years. Early registration is advised. Full agenda inside. Dear Colleague: Our understanding of thrombosis and thromboembolism has evolved rapidly. Advances in prevention, diagnosis, management, epidemiology, and pathophysiology will improve our clinical practice and yield more favorable patient outcomes. Since 1997, this CME course, Thrombosis and Thromboembolism, has been providing practical and timely education about these innovations in the field. Our upcoming 2020 curriculum promises to be the best in this program’s 23-year history, with master clinicians updating and guiding us so we can integrate these changes into our daily practice. This biennial course provides an opportunity to quickly, efficiently, and effectively ensure we are current with the state of the art for: • The etiology and pathophysiology of atherothrombosis • Understanding of the link between inflammation and thrombotic illnesses • Dual therapy with low-dose anticoagulation and aspirin • Stroke prevention (and stroke prediction) in atrial fibrillation • Caring for patients who have or are at risk for deep vein thrombosis and pulmonary embolism — this is a comprehensive look, from every angle • The most exciting new predictive, diagnostic, and treatment options, including genetics, personalized medicine, and lipid biology • The nuances of prescribing dual antiplatelet therapy, including optimal duration and ways to minimize bleeding complications The 2020 course offers new and returning attendees a fast-paced, intellectually invigorating learning experience and a forum in which new professional friendships will take root with faculty and colleagues who share common interests. We have had the privilege of co-directing this course from its inception, and count ourselves among the many professionals who have been enriched by the knowledge-sharing and networking opportunities that this special program offers. We hope you will attend, and we look forward to welcoming you in person to this special Boston event.

Samuel Z. Goldhaber, MD Paul M Ridker, MD, MPH Course Director Course Director Professor of Medicine, Harvard Medical School Eugene Braunwald Professor of Medicine Associate Chief and Clinical Director Harvard Medical School Division of Cardiovascular Medicine Director, Center for Cardiovascular Disease Prevention Section Head, Vascular Medicine Senior Physician Director, Thrombosis Research Group Brigham and Women’s Hospital Brigham and Women’s Hospital Harvard Medical School Faculty Deepak L. Bhatt, MD, MPH Peter Libby, MD Paul M Ridker, MD, MPH Professor of Medicine Mallinckrodt Professor of Medicine Eugene Braunwald Professor of Medicine Erin Bohula, MD, DPhil Bradley A. Maron, MD Christian T. Ruff, MD, MPH Instructor in Medicine Associate Professor of Medicine Assistant Professor of Medicine Eugene Braunwald, MD Michelle O’Donoghue, MD Marc Sabatine, MD, MPH Distinguished Hersey Professor of Associate Professor of Medicine Professor of Medicine Medicine Patrick T. O’Gara, MD Benjamin Scirica, MD Marie Gerhard-Herman, MD Professor of Medicine Associate Professor of Medicine Associate Professor of Medicine Marc Pfeffer, MD, PhD Piotr Sobieszczyk, MD Samuel Z. Goldhaber, MD Victor J. Dzau Professor of Medicine Instructor in Medicine Professor of Medicine Gregory Piazza, MD, MS Scott Solomon, MD Raj Gupta, MD Assistant Professor of Medicine Professor of Medicine Instructor in Medicine Jorge Plutzky, MD Anne Marie Valente, MD Galen Henderson, MD Associate Professor of Medicine Associate Professor of Pediatrics Assistant Professor of Neurology Aruna Pradhan, MD Assistant Professor of Medicine

Course Directors Samuel Z. Goldhaber, MD Paul M Ridker, MD, MPH Professor of Medicine, Harvard Medical School Eugene Braunwald Professor of Medicine, Associate Chief and Clinical Director, Harvard Medical School Division of Cardiovascular Medicine Director, Center for Cardiovascular Disease Prevention Section Head, Vascular Medicine Senior Physician, Brigham and Women’s Hospital Director, Thrombosis Research Group Brigham and Women’s Hospital

Now offering ABIM MOC Points Accreditation ACCREDITATION COUNCIL FOR CONTINUING MEDICAL EDUCATION The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The Harvard Medical School designates this live activity for a maximum of 15.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. AMERICAN BOARD OF INTERNAL MEDICINE Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 15.75 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC points. AMERICAN ACADEMY OF FAMILY PHYSICIANS This Live activity, Thrombosis and Thromboembolism, with a beginning date of 10/08/2020, has been reviewed and is acceptable for up to 15.75 Prescribed credit(s) by the American Academy of Family Physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity. AMERICAN NURSES CREDENTIALING CENTER Harvard Medical School is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation. This activity is approved for 15.75 contact hours, of which 15.75 is eligible for pharmacology credit. Contact hours are awarded commensurate with participation and completion of the online evaluation and attendance attestation. We suggest claiming your hours within 30 days of the activity date; after this time, the attendance attestation will still be required to claim your hours. PHYSICIAN ASSISTANTS The National Commission on Certification of Physician Assistants (NCCPA) states that AMA PRA Category 1 Credits™ are acceptable for continuing medical education requirements for recertification. We would also suggest that learners check with their state licensing board to ensure they accept reciprocity with AMA PRA Category 1 Credit™ for re-licensure. CANADIAN ACCREDITATION The Royal College of Physicians and Surgeons of Canada recognizes conferences and workshops held outside of Canada that are developed by a university, academy, hospital, specialty society or college as accredited group learning activities. EUROPEAN ACCREDITATION Through an agreement between the American Medical Association and the European Union of Medical Specialists, physicians may convert AMA PRA Category 1 Credit™ to an equivalent number of European CME Credits® (ECMECs®). Information on the process of converting AMA PRA Category 1 Credits™ to ECMECs® can be found at: www.eaccme.eu. Thrombosis and Thromboembolism 2020

Reasons to Attend

You will get timely and important updates for: • DVT/PE diagnosis, testing, parenteral and oral anticoagulants • Advanced therapies • Atherothrombosis: etiology, pathophysiology, therapy • Genetic factors • Infertility and hypercoagulability: testing and management • Aortic diseases • Lipid biology, especially triglycerides and lipoprotein(a) • Acute MI • Dual antiplatelet therapy: dose, duration, reversibility • CHIP • Stroke prevention (and prediction) in atrial fibrillation • VTE prophylaxis • Nutrition and thrombosis • Treating cancer patients • Diabetes and metabolic syndrome and thrombosis • Vasospastic diseases • Pulmonary hypertension • Endovascular intervention • Heart failure with preserved or reduced ejection fraction

Who Should Attend

PHYSICIANS, NPs, PAs, SURGEONS, PHARMACISTS and RESEARCHERS who work in the following fields of medicine and care for patients with or at risk for thromboses in the venous and arterial systems: • Hematology • Oncology • Family Medicine • Cardiovascular Medicine • Vascular Medicine • Internal Medicine • Critical Care Medicine • Pulmonary Medicine • Obstetrics • Hospital Medicine

Course Description Thrombosis and Thromboembolism provides a comprehensive review of the most important changes and advances impacting the care of patients who have—or are at risk for—these afflictions. Updates in diagnosis, treatment, and prevention are provided by world-renowned experts and Harvard Medical School’s leading clinical faculty. Thrombosis and Thromboembolism has provided practical and timely education about innovations in this field since 1997. First-time and returning attendees consistently report that the knowledge they acquire from this update changes their practice and drives better outcomes for patients. Participants have learned new advances in preventing VTE in medically ill patients; how dual anti-platelet therapy can prevent MI, stroke, and leg amputation; improved stroke prediction and prevention; and a better understanding of the link between inflammation and thrombotic illnesses. This acclaimed course, offered only once every two years, is intended for all general internists and cardiovascular, peripheral vascular, critical care, pulmonary, surgical, and hematologic specialists who are called upon to care for patients with thromboses in the venous and arterial systems. The course will be interactive with time set aside for active discussion with faculty.

Learning Objectives Upon completion of this course, participants will be able to: • Identify the etiology and pathophysiology of atherothrombosis • Recognize the link between inflammation and thrombotic illnesses • Explain new tools for stroke prevention (and stroke prediction) in atrial fibrillation • Identify the optimal duration of anticoagulation for PE and DVT • Provide advanced therapy beyond anticoagulation in PE and DVT: thrombolysis, catheter-directed therapy, surgical embolectomy • Explain the connection between diabetes, metabolic syndrome, and major adverse cardiac events • Provide patients with useful insights into how a heart-healthy diet can help prevent thrombosis • Manage a high-risk pregnancy Thrombosis and Thromboembolism 2020

Thursday, October 8

6:45am Registration and Continental Breakfast 8:00am Welcome and Course Objectives Samuel Z. Goldhaber, MD and Paul M Ridker, MD, MPH

I. VENOUS THROMBOSIS Session Chair: Gregory Piazza, MD, MS (All sessions include 10 minutes of Q&A and discussion) 8:15am Pulmonary Embolism: Disrupting Dogma Samuel Z. Goldhaber, MD 8:45am Genetics Update in VTE: Beyond Factor V Leiden and Prothrombin Gene Mutation Raj Gupta, MD 9:15am Treatment and Prevention of VTE in Cancer Patients Samuel Z. Goldhaber, MD

II. THROMBOSIS PHARMACOLOGY Session Chair: Samuel Z. Goldhaber, MD (All sessions include 10 minutes of Q&A and discussion) 9:45am Direct Oral Anticoagulants (DOACs): The Good, the Bad, and the Ugly Samuel Z. Goldhaber, MD 10:15am Coffee Break (Refreshments provided) 10:35am Management of Bleeding in Anticoagulated Patients Christian T. Ruff, MD, MPH 11:05am Advanced Therapies beyond Anticoagulation: ECMO, Surgery, Catheter-Directed Thrombolysis Gregory Piazza, MD, MS 11:35am Special Speaker: Eugene Braunwald, MD For more than 30 years, Dr. Braunwald has served as Chairman of the TIMI Study Group. Science Watch listed him as the most frequently cited author in cardiology; the living Nobel Prize winners in medicine voted Dr. Braunwald “the person who has contributed the most to cardiology in recent years.” 12:25pm Break for Lunch*

III. ARTERIAL THROMBOSIS Session Chair: Paul M Ridker, MD, MPH (Most sessions include 10 minutes of Q&A and discussion) 1:30pm Inflammation and Atherothrombosis: Where Are We Going? Paul M Ridker, MD, MPH 2:00pm Clonal Hematopoiesis of Indeterminate Potential (CHIP) Peter Libby, MD 2:30pm Diseases of the Aorta Patrick T. O’Gara, MD 3:00pm Novel Therapies for LDL Cholesterol and Lipoprotein(a) Jorge Plutzky, MD 3:30pm Coffee Break (Refreshments provided) 3:50pm Reducing Triglyceride Levels to Reduce Adverse Cardiovascular Outcomes Aruna Pradhan, MD 4:10pm Heart Failure with Preserved Ejection Fraction (HFPEF) Scott Solomon, MD 4:40pm Heart Failure with Reduced Ejection Fraction (HFREF) Marc Pfeffer, MD, PhD 5:10pm Stroke Galen Henderson, MD 5:40pm Daily Program Ends

Friday, October 9

7:00am Continental Breakfast

IV. SETTINGS OF THROMBOTIC RISK Session Chair: Gregory Piazza, MD, MS (Most sessions include 10 minutes of Q&A and discussion)

8:00am Thrombosis and Thromboembolism Jeopardy Gregory Piazza, MD, MS 8:30am Controversies in VTE Prophylaxis for Orthopedic Surgery Samuel Z. Goldhaber, MD 9:00am Infertility and Hypercoagulability Gregory Piazza, MD, MS 9:30am How to Manage High-Risk Pregnancy Anne Marie Valente, MD 10:00am Coffee Break (Refreshments provided)

V. ISSUES IN ANTIPLATELET AND ANTITHROMBOTIC THERAPY Session Chair: Paul M Ridker, MD, MPH (All sessions include 10 minutes of Q&A and discussion)

10:20am Atrial Fibrillation: Newest Perspectives Christian T. Ruff, MD, MPH 10:50am Single Versus Dual Antiplatelet Therapy Erin Bohula, MD, DPhil 11:20am Management of Acute Myocardial Infarction Marc Sabatine, MD, MPH 12:10pm Break for Lunch*

VI. VASCULAR MEDICINE Session Co-Chairs: Samuel Z. Goldhaber, MD and Paul M Ridker, MD, MPH (All sessions include 10 minutes of Q&A and discussion)

1:10pm Voyager and Uptake of the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial Deepak L. Bhatt, MD, MPH 1:40pm Pulmonary Hypertension Bradley A. Maron, MD 2:10pm Effect of Systolic and Diastolic Blood Pressure on Myocardial Infarction and Stroke Deepak L. Bhatt, MD, MPH 2:40pm Raynaud’s and Other Vasospastic Disease Marie Gerhard-Herman, MD 3:10pm Diabetes, Metabolic Syndrome, and Major Adverse Cardiac Events Benjamin Scirica, MD 4:00pm Endovascular Intervention in the Cath Lab Piotr Sobieszczyk, MD 4:40pm Can Your Kitchen Prevent Thrombosis? Michelle O’Donoghue, MD 5:10pm Course Adjourns

*There are many convenient and varied lunch options within a short walking distance of the course. Program changes/substitutions may be made without notice. To view the most up-to-date version of the course program, please visit the course website.

This program is among the highest-rated Harvard Medical School CME courses. It is offered once every two years. To be assured a place in the 2020 program, early registration is strongly advised. Registration Information

Thrombosis and Thromboembolism Register after Register on or before Course #732495-2101 August 31, 2020 August 31, 2020

Physicians $895 $795 (Save $100)

Allied Health Professionals $795 $695 (Save $100) Residents and Fellows

Tuition includes breakfast each morning, and morning and afternoon refreshment breaks. Complimentary internet will be provided in the meeting room. All attendees of Thrombosis and Thromboembolism will receive a printed course syllabus.

Registration, Payment, Confirmation and Refund Policy Registrations for Harvard Medical School CME programs are made via our secure online registration system. To register for this course, please visit the course website at Thrombosis.HMSCME.com. At the end of the registration process, a $10 non-refundable processing fee will be added to your registration, and you will have the choice of paying by check, credit card (Visa, MasterCard, or American Express), or wire transfer in USD. If you are paying by check (draft on a United States bank) or by wire transfer, the online registration system will provide you with instructions for remitting your course fees. Postal, telephone, fax, and cash-payment registrations are not accepted. All fees shown in USD. Upon receipt of your paid registration, an email confirmation will be sent to you. Be sure to include an email address that you check frequently. Your email address is used for critical information, including registration confirmation, evaluation, and certificate. Please do not make non-refundable travel arrangements until you have received an email from our office confirming your paid registration. Refunds, less an administrative fee of $75, will be issued for all cancellations received two weeks prior to the start of the course. Refund requests must be received by email. No refund will be issued should cancellation occur less than two weeks prior. “No shows” are subject to the full course fee and no refunds will be issued once the course has started.

Questions? Call 617-384-8600 Monday-Friday 9am – 5pm (ET) or send email to [email protected] Venue Fairmont Copley Plaza 138 St. James Avenue Boston, Massachusetts 617-267-5300

Accommodations Fairmont Copley Plaza has reserved a block of discounted rooms for course participants. Important to note: • The number of discounted rooms is limited. • Discounted rooms are available on a first-come, first-served basis. • The discounted room rate is only available until September 14, 2020, or until the block sells out, which typically happens well in advance of this date. To reserve your room: • Online: To reserve your room online, please visit Thrombosis.HMSCME.com/Venue (the Venue page of the course website) and click on the dedicated reservation link. • By phone: If you are calling the hotel rather than using the dedicated link to request a discounted room, please call 1-866-540-4417 and specify that you are enrolled in Thrombosis and Thromboembolism.