bioRxiv preprint doi: https://doi.org/10.1101/062711; this version posted August 15, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 A conceptual view at microtubule plus end dynamics in neuronal axons André Voelzmann1, Ines Hahn1, Simon P. Pearce1,2, Natalia Sánchez-Soriano3, Andreas Prokop1 1) The University of Manchester, Faculty of Biology, Medicine and Health, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK 2) The University of Manchester, School of Mathematics, Alan Turing Building, Oxford Road, Manchester M13 9PL, UK 3) University of Liverpool, Institute of Translational Medicine, Department of Cellular and Molecular Physiology, Crown Street, Liverpool, L69 3BX, UK Running title: Axonal microtubule dynamics Key words: cytoskeleton; microtubules; axons; neurons; Drosophila 4) Author for correspondence: Andreas Prokop The University of Manchester Michael Smith Building Oxford Road Manchester M13 9PT Tel: +44-(0)161-27-51556 Fax: +44-(0)161-27-51505
[email protected] Abstract Axons are the cable-like protrusions of neurons which wire up the nervous system. Polar bundles of microtubules (MTs) constitute their structural backbones and are highways for life- sustaining transport between proximal cell bodies and distal synapses. Any morphogenetic changes of axons during development, plastic rearrangement, regeneration or degeneration depend on dynamic changes of these MT bundles. A key mechanism for implementing such changes is the coordinated polymerisation and depolymerisation at the plus ends of MTs within these bundles.