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Identification and characterization of glycoside family 32 from Aspergillus niger Goosen, Coenie

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Publication date: 2007

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REFERENCES

Abarca, M. L., Accensi, F., Cano, J. & Cabanes, F. J. (2004). Taxonomy and significance of black aspergilli. Antonie Van Leeuwenhoek 86 , 33-49.

Akimoto, H., Kushima, T., Nakamura, T. & Ohta, K. (1999). Transcriptional analysis of two endoinulinase genes inuA and inuB in Aspergillus niger and nucleotide sequences of their promoter regions. J Biosci Bioeng 88 , 599–604.

Akimoto, H., Kiyota, N., Kushima, T., Nakamura, T. & Ohta, K. (2000). Molecular cloning and sequence analysis of an endoinulinase gene from Penicillium sp. strain TN-88. Biosci Biotechnol Biochem 64 , 2328-2335.

Alberto, F., Bignon, C., Sulzenbacher, G., Henrissat, B. & Czjzek, M. (2004). The three- dimensional structure of invertase ( β-fructosidase) from Thermotoga maritima reveals a bimodular arrangement and an evolutionary relationship between retaining and inverting glycosidases. J Biol Chem 279 , 18903-18910.

Alberto, F., Jordi, E., Henrissat, B. & Czjzek, M. (2006). Crystal structure of inactivated Thermotoga maritima invertase in complex with the trisaccharide raffinose. Biochem J 395 , 457-462.

Altenbach, D., Nuesch, E., Ritsema, T., Boller, T. & Wiemken, A. (2005). Mutational analysis of the active center of plant fructosyltransferases: Festuca 1-SST and barley 6-SFT. FEBS Lett 579 , 4647-4653.

Arand, M., Golubev, A. M., Neto, J. R. N. & other authors (2002). Purification, charaterization, gene cloning and preliminary X-ray data of the exo-inulase from Aspergillus awamori . . Biochem J 362 , 131-135.

141 References

Arnold, J. & Hilton, N. (2003). Genome sequencing: Revelations from a bread mould. Nature 422 , 821-822. Bach Knudsen, K. E. & Hessov, I. (1995). Recovery of inulin from Jerusalem artichoke (Helianthus tuberosus L .) in the small intestine of man. Br J Nutr 74 , 101-113.

Bairoch, A. (2000). The database in 2000. Nucleic Acids Res 28 , 304-305.

Balakrishnan, M., Simmonds, R. S. & Tagg, J. R. (2006). Dental caries is a preventable infectious disease. Aust Dent J 45 , 235-245.

Barbier, O., Girard, C., Breton, R., Belanger, A. & Hum, D. W. (2000). N-glycosylation and residue 96 are involved in the functional properties of UDP- enzymes. Biochemistry 39 , 11540-11552.

Batista, F. R., Hernandez, L., Fernandez, J. R., Arrieta, J., Menendez, C., Gomez, R., Tambara, Y. & Pons, T. (1999). Substitution of Asp-309 by Asn in the Arg-Asp-Pro (RDP) motif of Acetobacter diazotrophicus levansucrase affects sucrose hydrolysis, but not enzyme specificity. Biochem J 337 , 503-506.

Beisel, H. G., Kawabata, S., Iwanaga, S., Huber, R. & Bode, W. (1999). Tachylectin-2: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus . Embo J 18 , 2313-2322.

Bendtsen, J. D., Jensen, L. J., Blom, N., von Heijne, G. & Brunak, S. (2004). Feature- based prediction of non-classical and leaderless protein secretion. Protein Eng Des Sel 17 , 349–356.

Bennet, J. W., Lasure, L. L., Bennet, J. W. & Lasure, L. L. (1991). Growth Media. In More gene manipulation in fungi , pp. 441-457. New York: Academic Press.

Bhatti, H. N., Asgher, M., Abbas, A., Nawaz, R. & Sheikh, M. A. (2006). Studies on kinetics and thermostability of a novel acid invertase from Fusarium solani J Agric Food Chem 54 , 4617-4623.

142 References

Boddy, L. M., Berges, T., Barreau, C., Vainstein, M. H., Dobson, M. J., Ballance, D. J. & Peberdy, J. F. (1993). Purification and characterisation of an Aspergillus niger invertase and its DNA sequence. Curr Genet 24 , 60-66.

Bos, C. J., Debets, A. J., Swart, K., Huybers, A., Kobus, G. & Slakhorst, S. M. (1988). Genetic analysis and the construction of master strains for assignment of genes to six linkage groups in Aspergillus niger. Curr Genet 14 , 437-443.

Burne, R. A. & Penders, J. E. (1992). Characterization of the Streptococcus mutans GS-5 fruA gene encoding exo-beta-D-fructosidase. Infect Immun 60 , 4621-4632.

Cairns, A. J. & Ashton, J. E. (1991). The interpretation of in vitro measurements of fructosyl activity: an analysis of patterns of fructosyl transfer by fungal invertase. New Phytol 118 , 24-33.

Cairns, A. J. (2003). Fructan biosynthesis in transgenic plants. J Exp Bot 54 , 549-567.

Carroll, S. B. (2003). Genetics and the making of Homo sapiens . Nature 422 , 849-857.

Cerning, J. (1990). Exocellular polysaccharides produced by lactic acid bacteria. FEMS Microbiol Rev 87 , 113-130.

Cha´vez, F. P., Pons, T., Delgado, J. M. & Rodrı´guez, L. (1998). Cloning and sequence analysis of the gene encoding invertase (INV1) from the yeast Candida utilis. Yeast 14 , 1223– 1232.

Chenna, R., Sugawara, H., Koike, T., Lopez, R., Gibson, T. J., Higgins, D. G. & Thompson, J. D. (2003) . Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res 31 , 3497–3500

Chiou, C. Y., Wang, H. H. & Shaw, G. C. (2002). Identification and characterization of the non-PTS fru locus of Bacillus megaterium ATCC 14581. Mol Genet Genomics 268 , 240–248.

143 References

Collins, F. S., Green, E. D., Guttmacher, A. E. & Guyer, M. S. (2003a). A vision for the future of genomics research. Nature 422 , 835-847.

Collins, F. S., Morgan, M. & Patrinos, A. (2003b). The Human Genome Project: lessons from large-scale biology. Science 300 , 286-290.

Coudray, C., Rambeau, M., Feillet-Coudray, C., Tressol, J. C., Demigne, C., Gueux, E., Mazur, A. & Rayssiguier, Y. (2005). Dietary inulin intake and age can significantly affect intestinal absorption of calcium and magnesium in rats: a stable isotope approach. Nutr J 4, 29.

Coutinho, P. M., Henrissat, B., Gilbert, H. J., Davies, G., Henrissat, B. & Svensson, B. (1999). Carbohydrate-active enzymes: an integrated database approach. In Recent Advances in Carbohydrate Bioengineering , pp. 3-12. Cambridge: The Royal Society of Chemistry.

Crooks, G. E., Hon, G., Chandonia, J. M. & Brenner, S. E. (2004). WebLogo: a sequence logo generator. Genome Res 14 , 1188-1190.

Cummings, J. H., Macfarlane, G. T. & Englyst, H. N. (2001). Prebiotic digestion and fermentation. Am J Clin Nutr 73 , 415S-420S.

Davies, G. & Henrissat, B. (1995). Structures and mechanisms of glycosyl . Structure 3, 853-859.

Davies, G. J., Wilson, K. S. & Henrissat, B. (1997). Nomenclature for sugar-binding subsites in glycosyl hydrolases. Biochem J 321 , 557-559.

Delzenne, N. M. & Kok, N. (2001). Effects of fructan-type prebiotics on lipid metabolism. Am J Clin Nutr 73 , 456-458. de Ruiter-Jacobs, Y. M., Broekhuijsen, M., Unkles, S. E., Campbell, E. I., Kinghorn, J. R., Contreras, R., Pouwels, P. H. & van den Hondel, C. A. (1989). A gene transfer system based on the homologous pyrG gene and efficient expression of bacterial genes in Aspergillus oryzae. Curr Genet 16 , 159-163.

144 References de Vries, R. P., van Grieken, C., van Kuyk, P. A. & Wo¨ sten, H. A. B. (2005). The value of genome sequences in the rapid identification of novel genes encoding specific plant cell wall degrading enzymes. Curr Genom 6, 157–187.

Dorta, C., Cruz, R., de Oliva-Neto, P. & Moura, D. J. (2006). Sugarcane molasses and yeast powder used in the Fructooligosaccharides production by Aspergillus japonicus -FCL 119T and Aspergillus niger ATCC 20611. J Ind Microbiol Biotechnol 33 , 1003-1009.

Dowzer, C. E. & Kelly, J. M. (1991). Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans . Mol Cell Biol 11 , 5701-5709.

Druart, N., De Roover, J., Van den Ende, W., Goupil, P., Van Laere, A. & Rambour, S. (2001). Sucrose assimilation during early developmental stages of chicory ( Cichorium intybus L.) plants. Planta 212 , 436-443.

Eddy, S. R. (1998). Profile hidden Markov models. Bioinformatics 14 , 755–763.

Ettalibi, M. & Baratti, J. C. (1987). Purification, properties and comparison of invertase, exoinulinases and endoinulinases of Aspergillus ficuum. Appl Microbiol Biotechnol 26 , 13-20.

Ettalibi, M. & Baratti, J. C. (2001). Sucrose hydrolysis by thermostable immobilized inulinases from Aspergillus ficuum . Enzyme Microb Technol 28 , 596-601.

Fleischmann, R. D., Adams, M. D., White, O. & other authors (1995). Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269 , 496-512.

Frazier, M. E., Johnson, G. M., Thomassen, D. G., Oliver, C. E. & Patrinos, A. (2003). Realizing the potential of the genome revolution: The Genomes to Life Program. Science 300 , 290-293.

Fuchs, A., de Bruijn, J. M. & Niedeveld, C. J. (1983). Bacteria and yeasts as possible candidates for the production of inulinases and levanases. Antonie van Leeuwenhoek 51 , 333- 351.

145 References

Galagan, J. E., Calvo, S. E., Cuomo, C. & other authors (2005a). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae . Nature 438 , 1105-1115.

Galagan, J. E., Henn, N. R., Ma, L. J., Cuomo, C. A. & Birren, B. (2005b). Genomics of the fungal kingdom: Insights into eukaryotic biology. Genome Res 15 , 1620-1631.

Gams, W., Christensen, M., Onions, A. H. S., Pitt, J. I. & Samson, R. A. (1985). Intrageneric taxa of Aspergillus and Penicillium systematics. pp. 55-62. Edited by R. A. Samson & J. I. Pitt. New York: Plenum Press.

Gascon, S. & Lampen, J. O. (1968). Purification of the internal invertase of yeast. J Biol Chem 243 , 1567-1572.

Ghazi, I., Fernandez-Arrojo, L., Garcia-Arellano, H., Ferrer, M., Ballesteros, A. & Plou, F. J. (2006). Purification and kinetic characterization of a fructosyltransferase from Aspergillus aculeatus . J Biotechnol 128 , 204-211.

Gibson, G. R. & Wang, X. (1994). Bifidogenic properties of different types of fructo- oligosaccharides. Food Microbiol 11 , 491-498.

Gibson, G. R., Beatty, E. R., Wang, X. & Cummings, J. H. (1995). Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108 , 975- 982.

Gill, P. K., Manhas, R. K., Singh, J. & Singh, P. (2004). Purification and characterization of an exoinulinase from Aspergillus fumigatus. Appl Biochem Biotechnol 117 , 19-32.

Goffeau, A., Barrell, B. G., Bussey, H. & other authors (1996). Life with 6000 genes. Science 274 , 546, 563-547.

Goosen, C., Yuan, X. L., van Munster, J. M., Ram, A. F., van der Maarel, M. J. & Dijkhuizen, L. (2007). Molecular and biochemical characterization of a novel intracellular invertase from Aspergillus niger with transfructosylating activity. Eukaryot Cell 9, 9.

146 References

Grootwassink, J. W. D. & Hewitt, G. M. (1983). Inducible and constitutive formation of β- fructofuranosidase (inulase) in batch and continuous cultures of the yeast Kluyveromyces fragilis. J Gen Microbiol 129 , 31–41.

Hendry, G. A. F. & Wallace, R. K. (1993). The origin, distribution and evolutionary significance of fructans. In Science and Technology of Fructans , pp. 119–139. Edited by M. Suzuki & N. J. Chatterton. Boca Raton, FL: CRC Press.

Hesse, S. J., Ruijter, G. J., Dijkema, C. & Visser, J. (2002). Intracellular pH homeostasis in the filamentous fungus Aspergillus nige. Eur J Biochem 269 , 3485-3494.

Heyer, A. G. & Wendenburg, R. (2001). Gene cloning and functional characterization by heterologous expression of the fructosyltransferase of Aspergillus sydowi IAM 2544. Appl Environ Microbiol 67 , 363-370.

Hirayama, M., Sumi, N. & Hidaka, H. (2006). Purification and characterization of a fructooligosaccharide-producing beta-fructofuranosidase from Aspergillus niger ATCC 20611. Agric Biol Chem 53 , 667-673.

Inoue, H., Nojima, H. & Okayama, H. (1990). High efficiency transformation of Escherichia coli with plasmids. Gene 96 , 23-28.

Jang, K. Y. & Hang, Y. D. (1996). Transfructosylating enzyme activity of Penicillium roquefortii . Lett Appl Microbiol 22 , 397-399.

Jasney, B. R., Roberts, L. (2003). Building on the DNA revolution. Science 300 , 277.

Jouve, L., Hoffman, L. & Hausman, J. F. (2004). Polyamine, carbohydrate, and praline content changes during salt stress exposure of aspen ( Populus tremula L. ): involvement of oxidation and osmoregulation metabolism. Plant Biol (Stuttg), 6, 74-80

Kaplan, H. & Hutkins, R. W. (2003). Metabolism of fructooligosaccharides by Lactobacillus paracasei 1195. Appl Environ Microbiol 69 , 2217–2222.

147 References

Kaur, N. & Gupta, A. K. (2002). Applications of inulin and oligofructose in health and nutrition. J Biosci 27 , 703-714.

Kim, H. Y. & Choi, Y. J. (2001). Molecular charaterization of cyloinulooligosaccharide fructanotransferase from Bacillus macerans . Appl Environ Microbiol 67 , 995-1000.

Kim, K. Y., Rhee, S. & Kim, S. I. (2005). Role of the N-terminal domain of endoinulinase from Arthrobacter sp. S37 in regulation of . J Biochem (Tokyo) 138 , 27-33.

Knudsen, B. K. E. & Hessov, I. (1995). Recovery of inulin from Jerusalem artichoke (Helianthus tuberosus L .) in the small intestine of man. Br J Nutr 74 , 101-113.

Kochhar, A., Kaur, N. & Gupta, A. K. (1997). Inulinase from Aspergillus versicolor : A potent enzyme for producing fructose from inulin. J Sci Ind Res 56 , 721-726.

Kochhar, A., Gupta, A. K. & Kaur, N. (1999). Purification and immobilisation of inulinase from Aspergillus candidus for producing fructose. J Sci Food Agric 79 , 549-554.

Koops, A. J. & Jonker, H. H. (1996). Purification and characterization of the enzymes of fructan biosynthesis in tubers of H elianthus tuberosus colombia (ii. purification of sucrose:sucrose 1-fructosyltransferase and reconstitution of fructan synthesis in vitro with purified sucrose:sucrose 1-fructosyltransferase and fructan:fructan 1-fructosyltransferase). Plant Physiol 110 , 1167-1175.

Kulminskaya, A. A., Arand, M., Eneyskaya, E. V., Ivanen, D. R., Shabalin, K. A., Shishlyannikov, S. M., Saveliev, A. N., Korneeva, O. S. & Neustroev, K. N. (2003). Biochemical characterization of Aspergillus awamori exoinulinase: substrate binding characteristics and regioselectivity of hydrolysis. Biochim Biophys Acta 1650 , 22-29.

Kusters-van Someren, M. A., Samson, R. A. & Visser, J. (1991). The use of RFLP analysis in classification of the black Aspergilli : reinterpretation of the Aspergillus niger aggregate. Curr Gen 19 , 21-26.

148 References

L'Hocine, L., Wang, Z., Jiang, B. & Xu, S. (2000). Purification and partial characterization of fructosyltransferase and invertase from Aspergillus niger AS0023. J Biotechnol 81 , 73-84.

Laloux, O., Cassart, J. P., Delcour, J., Van, B. J. & Vandenhaute, J. (1991). Cloning and sequencing of the inulinase gene of Kluyveromyces marxianus var. marxianus ATCC 12424. FEBS Lett 289 , 64-68.

Liebl, W., Brem, D. & Gotschlich, A. (1998). Analysis of the gene for β-fructosidase (invertase, inulinase) of the hyperthermophilic bacterium Thermotoga maritima , and characterisation of the enzyme expressed in Escherichia coli. Appl Microbiol Biotechnol 50 , 55-64.

Machida, M., Asai, K., Sano, M. & other authors (2005). Genome sequencing and analysis of Aspergillus oryzae . Nature 438 , 1157-1161.

May, T., Mackie, R. I., Fahey, G. C., Jr., Cremin, J. C. & Garleb, K. A. (1994). Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by Clostridium difficile . Scand J Gastroenterol 29 , 916-922.

Martin, I., Debarbouille, M., Ferrari, E., Klier, A. & Rapoport, G. (1987). Characterization of the levanase gene of Bacillus subtilis which shows homology to yeast invertases. Mol Gen Genet 208, 177–184.

McCarter, J. D. & Withers, S. G. (1994). Mechanisms of enzymatic glycoside hydrolysis. Curr Opin Struct Biol 4, 885-892.

McCKay, M. A., Norton, R. S. & Borowitzka, L. J. (1984). Organic osmoregulartory solutes in cyanobacteria. J Gen Microbiol 130 , 2177-2191

Meng, G. & Futterer, K. (2003). Structural framework of fructosyl transfer in Bacillus subtilis levansucrase. Nat Struct Biol 10 , 935-941.

Miasnikov, A. N. (1997). Characterization of a novel endo-levanase and its gene from Bacillus sp. L7. FEMS Microbiol Lett 154 , 23-28.

149 References

Moriyama, S., Akimoto, H., Suetsugu, N., Kawasaki, S., Nakamura, T. & Ohta, K. (2002). Purification and properties of an extracellular exoinulinase from Penicillium sp. strain TN-88 and sequence analysis of the encoding gene. Biosci Biotechnol Biochem 66 , 1887-1896.

Moriyama, S., Tanaka, H., Uwataki, M., Muguruma, M. & Ohta, K. (2003). Molecular cloning and characterization of an exoinulinase gene from Aspergillus niger strain 12 and its expression in Pichia pastoris. J Biosci Bioeng 96 324-331.

Muramatsu, M. & Nakakuki, T. (1995). Enzymatic synthesis of novel fructosyl and oligofructosyl trehaloses by Aspergillus sydowi β-fructofuranosidase. Biosci Biotechnol Biochem 59 , 208-212.

Nagem, R. A., Rojas, A. L., Golubev, A. M., Korneeva, O. S., Eneyskaya, E. V., Kulminskaya, A. A., Neustroev, K. N. & Polikarpov, I. (2004). Crystal structure of exo- inulinase from Aspergillus awamori : the enzyme fold and structural determinants of substrate recognition. J Mol Biol 344 , 471-480.

Naumoff, D. G. (2001). β-fructosidase superfamily: homology with some alpha-L-arabinases and beta-D-xylosidases. Proteins 42 , 66-76.

Nguyen, Q. D., Mattes, F., Hoschke, Ç., Rezessy-szab¢, J. & Bhat, M. K. (1999). Production, purification and identification of fructooligosaccharides produced by beta- fructofuranosidase from Aspergillus niger IMI 303386. Biotechnol Lett 21 , 183-186.

Nierman, W. C., Pain, A., Anderson, M. J. & other authors (2005). Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus . Nature 438 , 1151- 1156.

Nurizzo, D., Turkenburg, J. P., Charnock, S. J., Roberts, S. M., Dodson, E. J., McKie, V. A., Taylor, E. J., Gilbert, H. J. & Davies, G. J. (2002). Cellvibrio japonicus alpha-L- arabinanase 43A has a novel five-blade beta-propeller fold. Nat Struct Biol 9, 665-668.

150 References

Ohta, K., Akimoto, H., Matsuda, S., Toshimitsu, D. & Nakamura, T. (1998). Molecular cloning and sequence analysis of two endoinulinase genes from Aspergillus niger . Biosci Biotechnol Biochem 62 , 1731-1738.

Olah, A., Papp, Z. & Szentirmai, A. (1993). Inulin formation of penicillin producing industrial Penicillium chrysogenum strains. Acta Microbiol Hung 40 , 379-386.

Olempska-Beer, Z. S., Merker, R. I., Ditto, M. D. & DiNovi, M. J. (2006). Food- processing enzymes from recombinant microorganisms--a review. Regul Toxicol Pharmacol 45 , 144-158.

Onodera, S. & et al. (1996). Molecular cloning and nucleotide sequences of cDNA and gene encoding endo-inulase from Penicillium purpurogenum . Biosci Biotechnol Biochem 60 , 1780-1785.

Osman, N., Adawi, D., Molin, G., Ahrne, S., Berggren, A. & Jeppsson, B. (2006). Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats. BMC Gastroenterol 6, 31.

Ozimek, L. K., Kralj, S., van der Maarel, M. J. & Dijkhuizen, L. (2006). The levansucrase and inulosucrase enzymes of Lactobacillus reuteri 121 catalyse processive and non- processive transglycosylation reactions. Microbiology 152 , 1187-1196.

Pandey, A., Soccol, C. R., Selvakumar, P., Soccol, V. T., Krieger, N. & Fontana, J. D. (1999). Recent developments in microbial inulinases. Its production, properties, and industrial applications. Appl Biochem Biotechnol 81 , 35-52.

Pel, H. J., de Winde, J. H., Archer, D. B. & other authors (2007). Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat Biotechnol 25 , 221- 231.

Penalva, M. A. & Arst, H., Jr (2002). Regulation of gene expression by ambient pH in filamentous fungi and yeasts. Microbiol Mol Biol Rev 66 , 426–446.

151 References

Pérez, J. A., Rodriguez, J., Rodriguez, L. & Ruiz, T. (1996). Cloning and sequence analysis of the invertase gene INV1 from the yeast Pichia anomala . Curr Genet 29 , 234–240.

Pilon-Smits, E. A. H., Ebskamp, M. J. M., Paul, M. J., Jeuken, M. J. W., Weisbeek, P. J. & Smeekens, S. C. M. (1995). Evaluation of safety on inulin and oligofructose as dietary fiber. Plant Physiol 107 , 125–130.

Pons, T., Olmea, O., Chinea, G., Beldarrain, A., Marquez, G., Acosta, N., Rodriguez, L. & Valencia, A. (1998). Structure model for family 32 of glycosyl-hydrolase enzymes. Proteins 33 , 383–395.

Pons T., O. O., Chinea G, Beldarrain A, Marquez G, Acosta N, Rodriguez L, Valencia A. (2002). Structural model for family 32 of glycosyl-hydrolase enzymes. Protein Struct Funct Genet 33 , 383-395.

Pons, T., Naumoff, D. G., Martinez-Fleites, C. & Hernandez, L. (2004). Three acidic residues are at the of a beta-propeller architecture in glycoside hydrolase families 32, 43, 62, and 68. Proteins 54 , 424-432.

Pool-Zobel, B. L. (2005). Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data. Br J Nutr 93 Suppl 1 , S73-90.

Punt, P. J., Oliver, R. P., Dingemanse, M. A., Pouwels, P. H. & van den Hondel, C. A. M. J. J. (1987). Transformation of Aspergillus based on the hygromycin B resistancemarker from Escherichia coli . Gene 56 , 117–124.

Punt, P. J. & van den Hondel, C. A. (1992). Transformation of filamentous fungi based on hygromycin B and phleomycin resistance markers. Methods Enzymol 216:447-57. , 447-457.

Punt, P. J., van Biezen, N., Conesa, A., Albers, A., Mangnus, J. & van den, H. C. (2002). Filamentous fungi as cell factories for heterologous protein production. Trends Biotechnol 20, 200-206.

152 References

Raina, S. & Missiakas, D. (1997). Making and breaking disulfide bonds. Annu Rev Microbiol 51:179-202. , 179-202.

Reddy, V. A. & Maley, F. (1990). Identification of an active-site residue in yeast invertase by affinity labeling and site-directed mutagenesis. J Biol Chem 265 , 10817-10820.

Reddy, A. & Maley, F. (1996). Studies on identifying the catalytic role of Glu-204 in the active site of yeast invertase. J Biol Chem 271 , 13953-13957.

Rehm, J., Willmitzer, L. & Heyer, A. G. (1998). Production of 1-kestose in transgenic yeast expressing a fructosyltransferase from Aspergillus foetidus. J Bacteriol 180 , 1305-1310.

Ritsema, T. & Smeekens, S. (2003a). Fructans: beneficial for plants and humans. Curr Opin Plant Biol 6, 223-230.

Ritsema, T. & Smeekens, S. C. (2003b). Engineering fructan metabolism in plants. J Plant Physiol 160 , 811-820.

Ritsema, T., Verhaar, A., Vijin, I. & Smeekens, S. (2004). Fructosyltransferase mutants specify a function for the beta-fructosidase motif of the sucrose-binding box in specifying the fructan type synthesized. Plant MolBiol 54 , 853-863.

Ritsema, T., Verhaar, A., Vijn, I. & Smeekens, S. (2005). Using natural variation to investigate the function of individual amino acids in the sucrose-binding box of fructan:fructan 6G-fructosyltransferase (6G-FFT) in formation. Plant Mol Biol 58 , 597-607.

Roach, J. C., Boysen, C., Wang, K. & Hood, L. (1995). Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics 26 , 345-353.

Roberfroid, M. B. (1996). Functional effects of food components and the gastrointestinal system: chicory fructooligosaccharides. Nutr Rev 54 , S38-S42.

Roberfroid, M. B. & Delzenne, N. M. (1998) . Dietary fructans. Annu Rev Nutr 18 , 117–143.

153 References

Roberfroid, M. B. (2000). Fructo-oligosaccharide malabsorption: benefit for gastrointestinal functions. Curr Opin Gastroenterol 16 , 173-177.

Rubio, M. C. & Maldonado, M. C. (1995). Purification and characterization of invertase from Aspergillus niger Curr Microbiol 31 , 80-83.

Ruijter, G. J. & Visser, J. (1997). Carbon repression in Aspergilli. FEMS Microbiol Lett 151 , 103-114.

Rumessen, J. J. & Gudmand-Hoyer, E. (2006). Fructans of chicory: intestinal transport and fermentation of different chain lenghts and relation to fructose and sorbitol malabsorbtion. Am J Clin Nutr 68 , 257-364.

Russell, R. R. B. (1990). Molecular genetics of glucan metabolism in oral streptococci. Arch Oral Biol 35 , 53S-58S.

Sambrook, J., Fritch, E. F. & Maniatis, T. (1989). Molecular cloning: A laboratory manual: Cold Spring Harbour Laboratory Press.

Sangeetha, P. T., Ramesh, M. N. & Prapulla, S. G. (2004). Production of fructosyl transferase by Aspergillus oryzae CFR 202 in solid-state fermentation using agricultural by- products. Appl Microbiol Biotechnol 65 , 530-537.

Sanger, F. & Coulson, A. R. (1975). A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J Mol Biol 94 , 441-446.

Sghir, A., Chow, J. M. & Mackie, R. I. (1998). Continuous culture selection of bifidobacteria and lactobacilli from human faecal samples using fructooligosaccharide as selective substrate. J Appl Microbiol 85 , 769-777.

Shiomi, N., Benkeblia, N. & Onodera, S. (2005). The metabolism of the fructooligosaccharides in onion bulbs: a comprehensive review. J Appl Glycosci 52 , 121-127.

154 References

Shipley, J. M., Grubb, J. H. & Sly, W. S. (1993). The role of glycosylation and phosphorylation in the expression of active human β-glucuronidase. J Biol Chem 268 , 12193- 12198.

Shroff, R. A., O’Connor, S. M., Hynes, M. J., Lockington, R. A. & Kelly, J. M. (1997). Null alleles of creA , the regulator of carbon catabolite repression in Aspergillus nidulans. Fungal Genet Biol 22 , 28–38.

Smith, L. M., Sanders, J. Z., Kaiser, R. J., Hughes, P., Dodd, C., Connell, C. R., Heiner, C., Kent, S. B. & Hood, L. E. (1986). Fluorescence detection in automated DNA sequence analysis. Nature 321 , 674-679.

Sobotka, L., Bratova, M., Slemrova, M., Manak, J., Vizd'a, J. & Zadak, Z. (1997). Inulin as the soluble fiber in liquid enteral nutrition. Nutrition 13 , 21-25.

Somiari, R. I., Brzeski, H., Tate, R., Bieleck, S. & Polak, J. (1997). Cloning and sequencing of an Aspergillus niger gene coding for [ β]-fructofuranosidase. Biotechnol Lett 19 , 1243-1247.

Straathof, A. J., Kieboom, A. P. & van, B. H. (1986). Invertase-catalysed fructosyl transfer in concentrated solutions of sucrose. Carbohydr Res 146 , 154-159.

Strandberg, L. & Enfors, S. O. (1991). Factors influencing inclusion body formation in the production of a fused protein in Escherichia coli. Appl Environ Microbiol 57 , 1669-1674.

Sturm, A. (1999). Invertases. Primary structures, functions, and roles in plant development and sucrose partitioning. Plant Physiol 121 , 1-8.

Tanaka, N., Ohuchi, N., Mukai, Y. & 7 other authors (1998). Isolation and characterization of an invertase and its repressor genes from Schizosaccharomyces pombe. Biochem Biophys Res Commun 245 , 246–253.

Tannock, G. W. (1997). Probiotic properties of lactic-acid bacteria: plenty of scope for fundamental R & D. Trends Biotechnol 15 , 270-274.

155 References

Taussig, R. & Carlson, M. (1983). Nucleotide sequences of the yeast SUC2 gene for invertase. Nucleic Acids Res 11 , 1943–1954.

The International Human Genome Sequencing Consortium (IHGSC)(2001). Initial sequencing and analysis of the human genome. Nature 409 , 860-921.

The International Human Genome Sequencing Consortium (IHGSC)(2004). Finishing the euchromatic sequence of the human genome. Nature 431 , 931-945.

Thompson, J. D., Higgins, D. G. & Gibson, T. J. (1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position- specific gap penalties and weight matrix choice. Nucleic Acids Res 22 , 4673–4680.

Tournas, V. H. (2005). Spoilage of vegetable crops by bacteria and fungi and related health hazards. Crit Rev Microbiol 31 , 33-44.

Uhm, T.,Chae, S., Lee,D., Kim, S.,Cassart, P. & Vandenhaute, J. (1998). Cloning and nucleotide sequence of the endoinulinase-encoding gene, inu2 , from Aspergillus ficuum. Biotechnol Lett 20 , 809–812.

Vainstein, M. H. & Peberdy, J. F. (1990). Solubilisation of a cell wall bound invertase in Aspergillus nidulans. FEMS Microbiol Lett 59 , 265–269.

Vainstein, M. H. & Peberdy, J. F. (1991). Regulation of invertase in Aspergillus nidulans : effect of different carbon sources. J Gen Microbiol 137 , 315–321.

Van den Ende, W., Michiels, A., Van Wonterghem, D., Vergauwen, R. & Van Laere, A. (2000). Cloning, developmental, and tissue-specific expression of sucrose:sucrose 1-fructosyl transferase from Taraxacum officinale . Fructan localization in roots. Plant Physiol 123 , 71- 80.

Van den Ende, W., Michiels, A., De Roover, J. & Van Laere, A. (2002). Fructan biosynthetic and breakdown enzymes in dicots evolved from different invertases. Expression of fructan genes throughout chicory development. Scient World J 2, 1281-1295

156 References van Hartingsveldt, W., Mattern, I. E., van Zeijl, C. M., Pouwels, P. H. & van den Hondel, C. A. (1987). Development of a homologous transformation system for Aspergillus niger based on the pyrG gene. Mol Gen Genet 206 , 71-75. van Hijum, S. A., Bonting, K., van der Maarel, M. J. & Dijkhuizen, L. (2001). Purification of a novel fructosyltransferase from Lactobacillus reuteri strain 121 and characterization of the levan produced. FEMS Microbiol Lett 205 , 323-328. van Hijum, S. A., van der Maarel, M. J. & Dijkhuizen, L. (2003). Kinetic properties of an inulosucrase from Lactobacillus reuteri 121. FEBS Lett 534 , 207-210. van Hijum, S. A., Kralj, S., Ozimek, L. K., Dijkhuizen, L. & van Geel-Schutten, I. G. (2006). Structure-function relationships of glucansucrase and fructansucrase enzymes from lactic acid bacteria. Microbiol Mol Biol Rev 70 , 157-176.

Vandamme, E. J. & Derycke, D. G. (1983). Microbial inulinases: fermentation process, properties, and applications. Adv Appl Microbiol 29:139-76. , 139-176.

Venter, J. C. e. a. (2001). The Sequence of the Human Genome. Science 291 , 1304-1351.

Verhaest, M., Ende, W. V., Roy, K. L., De Ranter, C. J., Laere, A. V. & Rabijns, A. (2005). X-ray diffraction structure of a plant glycosyl hydrolase family 32 protein: fructan 1- exohydrolase IIa of Cichorium intybus . Plant J 41 , 400-411.

Vijn, I. & Smeekens, S. (1999). Fructan: more than a reserve carbohydrate. Plant Physiol 120 , 351-359.

Wallis, G. L., Hemming, F. W. & Peberdy, J. F. (1997). Secretion of two β- fructofuranosidases by Aspergillus niger growing in sucrose. Arch Biochem Biophys 345 , 214-222.

Wang, X. & Gibson, G. R. (1993). Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. J Appl Bacteriol 75 , 373-380.

157 References

Watzl, B., Girrbach, S. & Roller, M. (2005). Inulin, oligofructose and immunomodulation. Br J Nutr 93 Suppl 1 , S49-55.

Yanai, K., Nakane, A., Kawate, A. & Hirayama, M. (2001). Molecular cloning and characterization of the fructooligosaccharide-producing beta-fructofuranosidase gene from Aspergillus niger ATCC 20611. Biosci Biotechnol Biochem 65 , 766-773.

Yuan, X. L., Goosen, C., Kools, H., van der Maarel, M. J. E. C., van den Hondel, C. A. M. J. J., Dijkshuizen, L. & Ram, A. F. J. (2006). Database mining and transcriptional analysis of genes encoding inulin-modifying enzymes of Aspergillus niger . Microbiology 152 , 3061-3073.

Yun, J. W. (1996). Fructooligosaccharides: occurrence, preparation, and application. Enzyme Microb Technol 19 , 107–117.

158