Entropy 2013, 15, 234-261; doi:10.3390/e15010234 OPEN ACCESS entropy ISSN 1099-4300 www.mdpi.com/journal/entropy Concept Paper Biosemiotic Entropy of the Genome: Mutations and Epigenetic Imbalances Resulting in Cancer Berkley E. Gryder 1,*, Chase W. Nelson 2 and Samuel S. Shepard 3 1 School of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA 2 Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA; E-Mail:
[email protected] (C.W.N.) 3 Centers for Disease Control and Prevention, Influenza Division, Atlanta, GA 30333, USA; E-Mail:
[email protected] (S.S.S.) * Author to whom correspondence should be addressed; E-Mail:
[email protected]; Tel.: +1-864-906-2506. Received: 1 November 2012; in revised form: 30 December 2012 / Accepted: 11 January 2013 / Published: 16 January 2013 Abstract: Biosemiotic entropy involves the deterioration of biological sign systems. The genome is a coded sign system that is connected to phenotypic outputs through the interpretive functions of the tRNA/ribosome machinery. This symbolic sign system (semiosis) at the core of all biology has been termed “biosemiosis”. Layers of biosemiosis and cellular information management are analogous in varying degrees to the semiotics of computer programming, spoken, and written human languages. Biosemiotic entropy—an error or deviation from a healthy state—results from errors in copying functional information (mutations) and errors in the appropriate context or quantity of gene expression (epigenetic imbalance). The concept of biosemiotic entropy is a deeply imbedded assumption in the study of cancer biology.