GNL3 Polyclonal Antibody

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PRODUCT DATA SHEET Bioworld Technology,Inc. GNL3 polyclonal antibody Catalog: BS8233 Host: Rabbit Reactivity: Human BackGround: Applications: Nucleostemin, also designated Nucleolar GTP-binding WB 1:500 - 1:2000 protein 3, is a member of the MMR1/HSR1 GTP-binding IF 1:10 - 1:100 protein family. It is expressed in the nucleoli of adult IP 1:50 - 1:100 CNS stem cells, primitive bone marrow cells, embryonic Storage&Stability: stem cells and in several cancer cell lines. Nucleostemin Store at 4°C short term. Aliquot and store at -20°C long is often used as a stem cell marker. Overexpression or de- term. Avoid freeze-thaw cycles. pletion of the protein can reduce cell proliferation in CNS Specificity: stem cells. Nucleostemin shuttles between the nucleus GNL3 polyclonal antibody detects endogenous levels of and the nucleolus and may be important in maintaining GNL3 protein. the proliferative capacity of stem cells. Nucleostemin is DATA: important in the growth regulation of liver cancer, gastric cancer and several other cancer types. The gene encoding Nucleostemin is localized to chromosome 3p21.1. Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Molecular Weight: ~ 62 kDa WesternBlot (WB) analysis of GNL3 polyclonal antibody Swiss-Prot: Note: Q9BVP2 For research use only, not for use in diagnostic procedure. Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific im- munogen and the purity is > 95% (by SDS-PAGE). Bioworld Technology, Inc. Bioworld technology, co. Ltd. Add： 1660 South Highway 100, Suite 500 St. Louis Park, Add： No 9, weidi road Qixia District Nanjing, 210046, MN 55416,USA. P. R. China. Email: [email protected] Email: [email protected] Tel: 6123263284 Tel: 0086-025-68037686 Fax: 6122933841 Fax: 0086-025-68035151 .

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Interplay Between Human Nucleolar GNL1 and RPS20 Is Critical To
www.nature.com/scientificreports OPEN Interplay between human nucleolar GNL1 and RPS20 is critical to modulate cell proliferation Received: 19 February 2018 Rehna Krishnan, Neelima Boddapati & Sundarasamy Mahalingam Accepted: 13 July 2018 Human Guanine nucleotide binding protein like 1 (GNL1) belongs to HSR1_MMR1 subfamily of nucleolar Published: xx xx xxxx GTPases. Here, we report for the frst time that GNL1 promotes cell cycle and proliferation by inducing hyperphosphorylation of retinoblastoma protein. Using yeast two-hybrid screening, Ribosomal protein S20 (RPS20) was identifed as a functional interacting partner of GNL1. Results from GST pull-down and co-immunoprecipitation assays confrmed that interaction between GNL1 and RPS20 was specifc. Further, GNL1 induced cell proliferation was altered upon knockdown of RPS20 suggesting its critical role in GNL1 function. Interestingly, cell proliferation was signifcantly impaired upon expression of RPS20 interaction defcient GNL1 mutant suggest that GNL1 interaction with RPS20 is critical for cell growth. Finally, the inverse correlation of GNL1 and RPS20 expression in primary colon and gastric cancers with patient survival strengthen their critical importance during tumorigenesis. Collectively, our data provided evidence that cross-talk between GNL1 and RPS20 is critical to promote cell proliferation. Te YawG/YIqF/HSR1_MMR1 GTP-binding protein subfamily of GTPases is evolutionarily conserved across from prokaryotes to mammals. Te members of this family have shown to be involved in ribosomal assembly and ribosomal RNA processing and are characterized by the presence of circular permutation of guanine nucleotide binding motifs1. Te guanine nucleotide motifs G1-G5 of YawG/YIqF GTPases are arranged in G5-G4-G1-G2-G3 order whereas G1-G2-G3-G4-G5 order in classical GTPases2.
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Allelic Expression Analysis of the Osteoarthritis Susceptibility Locus
Gee et al. BMC Medical Genetics 2014, 15:53 http://www.biomedcentral.com/1471-2350/15/53 RESEARCH ARTICLE Open Access Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1 Fiona Gee*, Clare F Clubbs, Emma VA Raine, Louise N Reynard and John Loughlin Abstract Background: An osteoarthritis (OA) susceptibility locus has been mapped to chromosome 3p21, to a region of high linkage disequilibrium encompassing twelve genes. Six of these genes are expressed in joint tissues and we therefore assessed whether any of the six were subject to cis-acting regulatory polymorphisms active in these tissues and which could therefore account for the association signal. Methods: We measured allelic expression using pyrosequencing assays that can distinguish mRNA output from each allele of a transcript single nucleotide polymorphism. We assessed RNA extracted from the cartilage and other joint tissues of OA patients who had undergone elective joint replacement surgery. A two-tailed Mann–Whitney exact test was used to test the significance of any allelic differences. Results: GNL3 and SPCS1 demonstrated significant allelic expression imbalance (AEI) in OA cartilage (GNL3, mean AEI = 1.04, p = 0.0002; SPCS1, mean AEI = 1.07, p < 0.0001). Similar results were observed in other tissues. Expression of the OA-associated allele was lower than that of the non-associated allele for both genes. Conclusions: cis-acting regulatory polymorphisms acting on GNL3 and SPCS1 contribute to the OA association signal at chromosome 3p21, and these genes therefore merit further investigation. Keywords: Osteoarthritis, Genetic risk, Single nucleotide polymorphism, Allelic imbalance, Linkage disequilibrium − Background rs6976 (C/T) and rs11177 (C/T) (p =7.24× 10 11 and − Osteoarthritis (OA) is a common disease of the synovial 1.25 × 10 10, respectively; odds ratio = 1.12 for the joint characterised by progressive loss of articular cartilage minor alleles).
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