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PRODUCT INFORMATION 6α-Naloxol Item No. 22146 CAS Registry No.: 20410-95-1 N Formal Name: (5α,6α)-4,5-epoxy-17-(2-propen- 1-yl)-morphinan-3,6,14-triol OH Synonyms: 6-hydroxy Naloxone, NLL MF: C19H23NO4 FW: 329.4 Purity: ≥98% Supplied as: A crystalline solid HO O H OH Storage: -20°C Stability: ≥5 years Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis. Description 6α-Naloxol (Item No. 22146) is an analytical reference material categorized as an opioid. It is an active metabolite of naloxone (Item No. ISO60191 | 15594) that has approximately the same binding affinity as naloxone for µ- and δ-opioid receptors.1 This product is intended for research and forensic applications. This product is qualified as a Reference Material that has been manufactured and tested to ISO/IEC 17025 and ISO 17034 international standards. Reference 1. Wang, D., Raehal, K.M., Bilsky, E.J., et al. Inverse agonists and neutral antagonists at µ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependence. J. Neurochem. 77(6), 1590-1600 (2001). WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD SAFETY DATA ANN ARBOR, MI 48108 · USA This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution. PHONE: [800] 364-9897 WARRANTY AND LIMITATION OF REMEDY [734] 971-3335 Buyer agrees to purchase the material subject to Cayman’s Terms and Conditions. Complete Terms and Conditions including Warranty and Limitation of Liability information can be found on our website. FAX: [734] 971-3640 [email protected] Copyright Cayman Chemical Company, 08/09/2019 WWW.CAYMANCHEM.COM.

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