DOCSLIB.ORG

Opioid Analytical Standards

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Opioid Analytical Standards Opioid Analytical Standards Cayman Chemical is dedicated to working with the forensic community to quickly make authentic reference standards available from our ISO/IEC 17025 and ISO 17034 laboratories. In response to the opioid epidemic, our catalog has expanded to now contain more than 600 opioid standards to help identify, confirm, and quantify these drugs of abuse. This includes a wide collection of fentanyls and other emerging synthetic opioids as well as plant-derived opiates and their metabolites and internal standards. A library of mass spectral data containing many of Cayman’s emerging opioid standards is freely available for download at www.caymanchem.com/CSL. More than 600 Opioid Standards for · Synthetic Opioids · Opiates & Natural Products - Fentanyls - Prescription Drugs - Utopioids - Semi-Synthetic Opiates - AH-, MT-45, & W-Series - Opioid Antagonists - Nitazenes - Emerging Classes Tools to Rapidly Screen for Prevalent Opioids Abundance 10.819 Synthetic Opioid Mixtures 8e+07 7.5e+07 11.294 11.485 7e+07 11.878 GC-MS Opioid Mixture 1 6.5e+07 6e+07 Item No. 23629 5.5e+07 12.369 5e+07 14.030 4.5e+07 A mixture of 7 common synthetic opioids (1 mg/ml 14.306 4e+07 3.5e+07 of each): acetyl fentanyl, acrylfentanyl, butyryl 3e+07 10.643 2.5e+07 fentanyl, cyclopropyl fentanyl, fentanyl, furanyl 2e+07 1.5e+07 fentanyl, and U-47700 1e+07 5000000 Time--> 10.20 10.40 10.60 10.80 11.00 11.20 11.4011.60 11.80 12.00 12.20 12.40 12.60 12.80 13.0013.20 13.40 13.60 13.8014.00 14.2014.40 14.60 14.80 GC-MS Opioid Mixture 2 Representative chromatogram of the compounds Item No. 23876 included in the GC-MS Opioid Mixture 2 A mixture of 8 common synthetic opioids (1 mg/ml Peak order from left to right: U-48800, U-49900, FIBF, ortho-fluorofentanyl, of each): cyclopentyl fentanyl, methoxyacetyl fentanyl, (±)-cis-3-methyl fentanyl, methoxyacetyl fentanyl, cyclopentyl fentanyl, (±)-cis-3-methyl fentanyl, tetrahydrofuran fentanyl, tetrahydrofuran fentanyl ortho-fluorofentanyl, FIBF, U-48800, and U-49900 Custom Opioid Mixtures, Screening Libraries, and Plates Available Email [email protected] to discuss your specific project needs 2020 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 WWW.CAYMANCHEM.COM Fentanyls The basic fentanyl scaffold can be modified in four 13 different regions leading to a myriad of new fentanyl C-Labeled Internal Standards varieties. Cayman now offers more than 380 standards 13 for the identification, confirmation, and quantification 4-ANPP- C6 (CRM) of fentanyls and their metabolites. Our scientists have N Item No. 26313 H also developed a naming convention to help provide N a more unambiguous way to describe substituent 13C H13C 13CH placement on the fentanyl scaffold. Read more about H13C 13CH 13C the standardized naming of substituted fentanyls at H www.caymanchem.com/fentanylnaming. H 13 13C Carfentanil- C (CRM) Parent Compounds H13C 13CH 6 13C 13CH N 13C Item No. 26904 Item No. Product Name O H ISO60128 Acetyl fentanyl (hydrochloride) (CRM) * N O O 23060 Acrylfentanyl (hydrochloride) (CRM) * 25936 Benzyl fentanyl (hydrochloride) (CRM) * 19734 Butyryl fentanyl (hydrochloride) (CRM) * H 13C H13C 13CH para-Fluorobutyryl 19884 Carfentanil (CRM) 13C 13CH 13 N 13C fentanyl- C 26637 Crotonyl fentanyl (CRM) * O H 6 N (hydrochloride) (CRM) 23603 Cyclopropyl fentanyl (hydrochloride) (CRM) * • HCl Item No. 26614 ISO60197 Fentanyl (hydrochloride) (CRM) * 25615 β-methyl Fentanyl (hydrochloride) (CRM) * F 21676 (±)-cis-3-methyl Fentanyl (hydrochloride) (CRM) * View a complete list of our isotopically labeled standards 19795 FIBF (hydrochloride) (CRM) * at www.caymanchem.com/forensics 19826 para-Fluorobutyryl fentanyl (hydrochloride) (CRM) * Metabolites 19633 Furanyl fentanyl (hydrochloride) (CRM) * Item No. Product Name 22750 para-fluoro Furanyl fentanyl (hydrochloride) ISO60130 Acetyl norfentanyl (hydrochloride) (CRM) * 26050 meta-methoxy Furanyl fentanyl 22700 4-ANPP (CRM) * 23540 Methoxyacetyl fentanyl (hydrochloride) (CRM) * 19561 Butyryl norfentanyl (hydrochloride) (CRM) * 19635 Ocfentanil (hydrochloride) (CRM) * 25078 Cyclopropyl norfentanyl (hydrochloride) (CRM) * 25887 Phenyl fentanyl (hydrochloride) (CRM) * 26427 Despropionyl ortho-Fluorofentanyl (CRM) * 22429 Remifentanil (hydrochloride) (CRM) * 26428 Despropionyl para-Fluorofentanyl (CRM) * 22802 Thiophene fentanyl (hydrochloride) 20789 β-hydroxy Fentanyl (hydrochloride) 19798 Valeryl fentanyl (CRM) * 19559 Furanyl norfentanyl (hydrochloride) (CRM) * * Compound also available as a neat solid 22182 Norcarfentanil (hydrochloride) (CRM) * ISO60195 Norfentanyl (CRM) * Request a copy of our 9001142 Norsufentanil Fentanyl Laboratory Guide wall poster 21926 Remifentanil Acid (trifluoroacetate salt) at www.caymanchem.com/literature * Compound also available as a neat solid 2020 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 WWW.CAYMANCHEM.COM Non-Fentanyl Synthetic Opioids Utopioids & Metabolites Item No. Product Name Utopioid Lab Guide Wall Poster 27925 UF-17 (hydrochloride) In this guide to the identification, naming, and 27924 Furanyl UF-17 (hydrochloride) metabolism of U-type opioids: 19397 U-47700 (CRM) * · Common EI-GC-MS Utopioid Fragments 24289 N,N-didesmethyl U-47700 (trifluoroacetate salt) (CRM) * · Mass Spectrum of U-47700 28689 3,4-difluoro U-47700 · Tips for GC-MS Interpretation 29561 3,4-difluoro Isopropyl U-47700 · Halogen Isotope Patterns 29560 3,4-difluoro-N-desmethyl U-47700 (hydrochloride) · Utopioid Metabolism 24263 Isopropyl U-47700 Common C-MS Halogen sotope atterns Utopioid raments Monochloro 139 T tur d f O Latory d or 111 Cl 37 O C v act N N 31 H H O N N N Cl Br heigh a f MM (111113, 139141) UTOPIOID 141 m/20 m/16 m/13 m/13 m/13 113 O O Idtifica, N, N O O O Cl 20530 U-47931E O Cl O Cl N Cl O 100 110 120 130 140 150 HN U-48520 O Cl F3C O Cl d Metabolism Cl m/16 m/13 m/13 m/166 m/163 m/15 m/15 Dichloro O O O 145 O O Cl Cd w 3 13 a f MM (14147, 17317) N O 14 Br O2N O Cl F3C Cl 15 O Cl m/155 m/153 m/150 m/14 m/14 m/145 m/145 m/13 N N Definin topioids Cl O O U-47700 130 140 150 160 10 10 10 O N O Amide Linker N N NC N O2N HO 29563 4-fluoro U-47931E H H m/13 m/13 m/130 m/125 m/122 m/121 m/121 m/112 U- d, Monobromo U-d U-d, d O T tur d f metabolit acterizd y 81Br v act HN HN trans-clohed ty d 11 Cl 155 13 Cl HN NC NH2 HO their d , linkd heigh a f MM N 15 15 together y d y (117, 18318) m/112 m/112 m/111 m/111 m/102 m/=97 m/3 N O Commonly detected utopioids Cl U-47700, U-48800, U-49900, U-174, N N N NH N 140 150 160 10 10 10 200 HN 3,4-Methdxy U-47700, Br 25522 U-48800 (hydrochloride) (CRM) * m/1 m/4 m/1 m/0 Isoprop U-47700 Phenyl Ring trans-Cyclohexanediamine methyl Common ubstitutions Mass pectrum of R4 Utopioid etabolism and ips for nterpretation O O OH R4 O Cl N NH N B Cl Abundance 4 N N HN O O 600,000 OH m/4 Cl A Cl N N O A O B O R R R N NH 550,000 5 3 3 Cl Cl Cl Cl Cl N N N N NH NH2 N Cl 2 Cl 500,000 R2 R1 R2 R1 U-400 Metabolism 29564 2,4-difluoro U-48800 (hydrochloride) N 450,000 Cl m/32 OH N · r R₁-R₃ d R₅ dt y y bstitutions O Cl Common Metabolite 400,000 m/125 N · R₄ dt ring NH 125 Cl 350,000 (d, oxy , oup, etc.) B O 300,000 O O O Cl C Cl C A N Cl Cl N N N H 250,000 N NH NH Cl Cl NH2 2 A Cl Cl Cl 200,000 O U-400 Metabolism O Cl Cl Cl 150,000 m/145 N H 1 NH 110 145 Cl 100,000 42 5 13 Cl m/13 23999 U-49900 (CRM) * 50,000 98 iotransformation Pathway 32 0 A) N-emethylation ) Hydroxylation C) N-eethylation m/z--> 40 50 60 70 80 90 100 110 120 130 140 150 160 10 10 10 200 210 220 230 240 250 260 20 20 20 300 310 320 330 Tips for GC-MS Interpretation · Utd dg d d d · T 84 d 1 dtiv f O · Hydoxyla cur ver clohe ing thylcyclohe-1,-d ty (right Cl N · U-47700 d U-49900 tabolit, N · Isot tt dtify Cl N-(-clohe)-3,4-d-N-thd ituen hen rimethylcycloheanediamine References · T lar (or M-1 ) Krot, A, Mohr, ALA, P, DM, et al. Drug Test Anal. 10(1), 17-136 (018) 29148 U-50488 (hydrochloride) (CRM) * esen very F, SW, Cooley, J.C, J, L, et al. J. nal. oxicol. 41(3), 173-180 (017) L d or ddd www.caymanchem.com/utopioids 019 C Ccal 29566 3,4-difluoro U-50488 (hydrochloride) Request a physical copy of this wall poster at 24264 U-51754 (hydrochloride) (CRM) * www.caymanchem.com/literature * Compound also available as a neat solid AH-, MT-45, & W-Series Opioids & Metabolites Nitazenes & Other Synthetic Opioids & Metabolites Item No. Product Name Item No. Product Name 19732 AH 7921 (CRM) * 27816 Brorphine (hydrochloride) 20280 N-desmethyl AH 7921 (hydrochloride) ISO60143 EDDP (perchlorate) (CRM) 19336 AH 8533 27255 Isotonitazene 19737 MT-45 (hydrochloride) (CRM) * 19406 Meperidine (hydrochloride) (CRM) 25288 2-fluoro MT-45 (hydrochloride) ISO60145 (±)-Methadone (hydrochloride) (CRM) * 25290 4-fluoro MT-45 (hydrochloride) 26398 Metonitazene 19482 W-15 (CRM) * 20899 Normeperidine (hydrochloride) (CRM) * 20413 W-15-d4 (CRM) 15912 (−)-Pentazocine 19483 W-18 (CRM) * 26335 Piperidylthiambutene (hydrochloride) 20366 W-18-d4 (CRM) ISO60184 (+)-Propoxyphene (hydrochloride) (CRM) 19713 nor-W-18 18660 Tapentadol (hydrochloride) (CRM) * 20317 nor-W-18-d4 25950 Tianeptine (sodium salt) 19484 W-19 (hydrochloride) ISO60149 cis-Tramadol (hydrochloride) (CRM) * 19487 W-19-d4 (hydrochloride) 18751 O-Desmethyl-cis-tramadol (hydrochloride) (CRM) * * Compound also available as a neat solid * Compound also available as a neat solid Be the first to know about novel synthetic opioids showing up in casework.
Load more

Recommended publications
  • Etodesnitazene
    Etodesnitazene Sample Type: Biological Fluid Latest Revision: February 23, 2021 Date of Report: February 23, 2021 1. GENERAL INFORMATION IUPAC Name: 2-[2-[(4-ethoxyphenyl)methyl]benzimidazol-1-yl]-N,N-diethyl- ethanamine InChI String: InChI=1S/C22H29N3O/c1-4-24(5-2)15-16-25-21-10-8-7-9-20(21)23- 22(25)17-18-11-13-19(14-12-18)26-6-3/h7-14H,4-6,15-17H2,1-3H3 CFR: Not Scheduled (02/2021) CAS# Not available Synonyms: Etazene, Desnitroetonitazene, Etazen, Etazone Source: Oregon State Police Forensic Laboratory Important Notes: All identifications were made based on evaluation of analytical data (LC-QTOF-MS) in comparison to analysis of acquired reference material. This drug was also confirmed via LC-MS/MS. Prepared By: Janet Schultz, PhD; Sailee Raje; Sara Short, MS, D-ABFT-FT; Michele Stauffenberg, MD; Alex J. Krotulski, PhD; Melissa F. Fogarty, MSFS, D-ABFT-FT; and Barry K. Logan, PhD, F-ABFT 2. CHEMICAL DATA Chemical Molecular Molecular Exact Mass Analyte Formula Weight Ion [M+] [M+H]+ Etodesnitazene C22H29N3O 351.5 351 352.2383 3. SAMPLE HISTORY Etodesnitazene has been identified in one case since December 2020. The geographical and demographical breakdown is below: Geographical Location: Oregon (n=1) Biological Sample: Subclavian Blood (n=1) Date of First Receipt: December 2020 Other Notable Findings: Etizolam, Methamphetamine, Mitragynine 4. BRIEF DESCRIPTION Etodesnitazene is classified as a novel opioid of the benzimidazole sub-class and is structurally dissimilar from fentanyl. Novel opioids have been reported to cause psychoactive effects similar to heroin, fentanyl, and other opioids.
    [Show full text]
  • DEPARTMENT of JUSTICE Drug Enforcement
    This document is scheduled to be published in the Federal Register on 08/03/2021 and available online at DEPARTMENT OF JUSTICEfederalregister.gov/d/2021-16499, and on govinfo.gov Drug Enforcement Administration Bulk Manufacturer of Controlled Substances Application: Cerilliant Corporation [Docket No. DEA-873] AGENCY: Drug Enforcement Administration, Justice. ACTION: Notice of application. SUMMARY: Cerilliant Corporation has applied to be registered as a bulk manufacturer of basic class(es) of controlled substance(s). Refer to Supplemental Information listed below for further drug information. DATES: Registered bulk manufacturers of the affected basic class(es), and applicants therefore, may file written comments on or objections to the issuance of the proposed registration on or before [INSERT DATE 60 DAYS AFTER DATE OF PUBLICATION IN THE FEDERAL REGISTER]. Such persons may also file a written request for a hearing on the application on or before [INSERT DATE 60 DAYS AFTER DATE OF PUBLICATION IN THE FEDERAL REGISTER]. ADDRESS: Written comments should be sent to: Drug Enforcement Administration, Attention: DEA Federal Register Representative/DPW, 8701 Morrissette Drive, Springfield, Virginia 22152. SUPPLEMENTARY INFORMATION: In accordance with 21 CFR 1301.33(a), this is notice that on June, 24, 2021, Cerilliant Corporation, 811 Paloma Drive, Suite A, Round Rock, Texas 78665-2402, applied to be registered as a bulk manufacturer of the following basic class(es) of controlled substance(s): Controlled Substance Drug Code Schedule 3-Fluoro-N-methylcathinone
    [Show full text]
  • Individual Patient & Medication Factors That Invalidate Morphine
    Individual Patient & Medication Factors that Invalidate Morphine Milligram Equivalents Presented on June 7-8, 2021 at FDA Collaborative with various Federal Government Agency Stakeholders Jeffrey Fudin, PharmD, FCCP, FASHP, FFSMB Clinical Pharmacy Specialist & PGY2 Pain Residency Director Stratton VAMC, Albany NY Adjunct Associate Professor Albany College of Pharmacy & Health Sciences, Albany NY Western New England University College of Pharmacy, Springfield MA President, Remitigate Therapeutics, Delmar NY Disclosures Affiliation Role/Activities Abbott Laboratories Speaking, non-speakers bureau AcelRx Pharmaceuticals Acute perioperative pain (speakers bureau, consulting, advisory boards) BioDelivery Sciences International Collaborative publications, consulting, advisory boards Firstox Laboratories Micro serum testing for substances of abuse (consulting) GlaxoSmithKline (GSK) Collaborative non-paid poster presentations) Hisamitsu America Inc Advisory Board Hikma Pharmaceuticals Advisory Board Scilex Pharmaceuticals Collaborative non-paid publications Salix Pharmaceuticals Speakers bureau, consultant, advisory boards Torrent Pharmaceuticals Lecture, non-speakers bureau Learning Objectives At the completion of this activity, participants will be able to: 1. Explain opioid conversion and calculation strategies when developing a care plan for patients with chronic pain. 2. Assess patient-specific factors that warrant adjustment to an opioid regimen. 3. Identify important drug interactions that can affect opioid serum levels. 4. Describe how pharmacogenetic differences can affect opioid efficacy, toxicity, and tolerability. Not All Opioids are Created Equally Issues with MEDD & Opioid Conversion1-4 › Pharmacogenetic variability › Drug interactions › Lack of universal morphine equivalence › Specific opioids that should never have an MEDD – Methadone, Buprenorphine, Tapentadol, Tramadol 1. Fudin J, Marcoux MD, Fudin JA. Mathematical Model For Methadone Conversion Examined. Practical Pain Management. Sept. 2012. 46-51. 2. Donner B, et al.
    [Show full text]
  • Report of the International Narcotics Control Board for 2020 (E/INCB/2020/1) Is Supplemented by the Following Reports
    INTERNATIONAL NARCOTICS CONTROL BOARD Report 2020 EMBARGO Observe release date: Not to be published or broadcast before Thursday 25 March 2021, at 1100 hours (CET) UNITED NATIONS CAUTION Reports published by the International Narcotics Control Board for 2020 TheReport of the International Narcotics Control Board for 2020 (E/INCB/2020/1) is supplemented by the following reports: Celebrating 60 Years of the Single Convention on Narcotic Drugs of 1961 and 50 Years of the Convention on Psychotropic Substances of 1971 (E/INCB/2020/1/Supp.1) Narcotic Drugs: Estimated World Requirements for 2021 — Statistics for 2019 (E/INCB/2020/2) Psychotropic Substances: Statistics for 2019 — Assessments of Annual Medical and Scientific Requirements for Substances in Schedules II, III and IV of the Convention on Psychotropic Sub- stances of 1971 (E/INCB/2020/3) Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psycho tropic Substances: Report of the International Narcotics Control Board for 2020 on the Implementation of Article 12 of the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988 (E/INCB/2020/4) The updated lists of substances under international control, comprising narcotic drugs, psycho­ tropic substances and substances frequently used in the illicit manufacture of narcotic drugs and psychotropic substances, are contained in the latest editions of the annexes to the statistical forms (“Yellow List”, “Green List” and “Red List”), which are also issued by the Board. Contacting the International Narcotics Control Board The secretariat of the Board may be reached at the following address: Vienna International Centre Room E­1339 P.O.
    [Show full text]
  • Communicationfile-132886.Pdf
    From: Nazlee Maghsoudi To: Board of Health Cc: Werb, Daniel; Hayley Thompson; Karen McDonald Subject: BOH June 14, 2021 - CDPE Comments on HL29.2 Date: June 13, 2021 6:52:20 PM Attachments: 2021-06-14_CDPE Comments to BOH_Toronto Overdose Action Plan Status Report 2021.pdf To the Members of the Board of Health, Please find attached comments from the Centre on Drug Policy Evaluation (CDPE) regarding agenda item HL29.2 (Toronto Overdose Action Plan: Status Report 2021) to be considered at the Board of Health meeting on Monday, June 14. We would greatly appreciate if you could please confirm receipt. Thanks so much, Nazlee Maghsoudi, BComm, MGA Doctoral Candidate, Health Services Research | Institute of Health Policy, Management and Evaluation, University of Toronto Manager, Policy Impact Unit | Centre on Drug Policy Evaluation (CDPE) Chairperson, Executive Committee | New York NGO Committee on Drugs (NYNGOC) Strategic Advisor | Canadian Students for Sensible Drug Policy (CSSDP) (647) 702-7825 Pronouns: She/Her Submission from Nazlee Maghsoudi, Centre on Drug Policy Evaluation Toronto's Dru·g Checking Service Coordinated by the Centre on Drug Policy Evaluation > i" Comments for Board of Health Consideration of “Toronto Overdose Action Plan: Status Report 2021” June 14, 2021 What does Toronto’s drug checking service do? • Offers people who use drugs timely and detailed information on the contents of their drugs, helping them to make more informed decisions • Shares information on Toronto’s unregulated drug supply to help harm reduction workers and clinicians tailor the care they provide to people who use drugs • Advocates for services and safer alternatives for people who use drugs 2 Free and anonymous drug checking is now available! What you give ..
    [Show full text]
  • Product Monograph Including Patient
    PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION INFORMATION NOxyNEO® Oxycodone Hydrochloride Controlled Release Tablets Tablets, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg and 80 mg, Oral Purdue Pharma Standard Opioid Analgesic Purdue Pharma Date of Initial Approval: 3381 Steeles Avenue East Suite 310 August 22, 2011 Toronto, ON M2H 3S7 Date of Revision: July 7, 2021 Submission Control No: 237808 OxyNEO® and HTR Technology™ are trademarks of Purdue Pharma OxyNEO® (oxycodone hydrochloride controlled release tablets) Page 1 of 41 RECENT MAJOR LABEL CHANGES 7 WARNINGS AND PRECAUTIONS, Neurologic, Serotonin Toxicity / Serotonin Syndrome, August 2020 7 WARNINGS AND PRECAUTIONS, Respiratory, Sleep Apnea, August 2020 TABLE OF CONTENTS RECENT MAJOR LABEL CHANGES ......................................................................................... 2 TABLE OF CONTENTS ............................................................................................................... 2 PART I: HEALTH PROFESSIONAL INFORMATION .................................................................. 4 1 INDICATIONS ................................................................................................................... 4 1.1 Pediatrics ................................................................................................................. 4 1.2 Geriatrics ................................................................................................................. 4 2 CONTRAINDICATIONS ..................................................................................................
    [Show full text]
  • Report on a Novel Emerging Class of Highly Potent Benzimidazole NPS Opioids: Chemical and in Vitro Functional Characterization of Isotonitazene
    Received: 29 August 2019 Revised: 12 November 2019 Accepted: 13 November 2019 DOI: 10.1002/dta.2738 RESEARCH ARTICLE Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene Peter Blanckaert1† | Annelies Cannaert2† | Katleen Van Uytfanghe2 | Fabian Hulpia3 | Eric Deconinck4 | Serge Van Calenbergh3 | Christophe Stove2 1Scientific Direction Epidemiology and Public Health, Section Lifestyle and Chronic Diseases, Abstract Belgian Early Warning System Drugs This paper reports on the identification and full chemical characterization of (BEWSD), Sciensano, Brussels, Belgium isotonitazene (N,N-diethyl-2-[5-nitro-2-({4-[(propan-2-yl)oxy]phenyl}methyl)-1H-ben- 2Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical zimidazol-1-yl]ethan-1-amine), a potent NPS opioid and the first member of the Sciences, Ghent University, Ghent, Belgium benzimidazole class of compounds to be available on online markets. Interestingly, 3Laboratory for Medicinal Chemistry, Department of Pharmaceutics, Faculty of this compound was sold under the name etonitazene, a structural analog. Identifica- Pharmaceutical Sciences, Ghent University, tion of isotonitazene was performed by gas chromatography mass spectrometry Ghent, Belgium (GC–MS) and liquid chromatography time-of-flight mass spectrometry (LC-QTOF- 4Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health MS), the latter identifying an exact-mass m/z value of 411.2398. All chromatographic Products, Sciensano, Brussels, Belgium data indicated the presence of a single, highly pure compound. Confirmation of the 1 13 Correspondence specific benzimidazole regio-isomer was performed using H and C NMR spectros- copy, after which the chemical characterization was finalized by recording Fourier- Christophe Stove, Laboratory of Toxicology, Department of Bioanalysis, Faculty of transform (FT-IR) spectra.
    [Show full text]
  • WHO Expert Committee on Drug Dependence
    WHO Technical Report Series 1034 This report presents the recommendations of the forty-third Expert Committee on Drug Dependence (ECDD). The ECDD is responsible for the assessment of psychoactive substances for possible scheduling under the International Drug Control Conventions. The ECDD reviews the therapeutic usefulness, the liability for abuse and dependence, and the public health and social harm of each substance. The ECDD advises the Director-General of WHO to reschedule or to amend the scheduling status of a substance. The Director-General will, as appropriate, communicate the recommendations to the Secretary-General of the United Nations, who will in turn communicate the advice to the Commission on Narcotic Drugs. This report summarizes the findings of the forty-third meeting at which the Committee reviewed 11 psychoactive substances: – 5-Methoxy-N,N-diallyltryptamine (5-MeO-DALT) WHO Expert Committee – 3-Fluorophenmetrazine (3-FPM) – 3-Methoxyphencyclidine (3-MeO-PCP) on Drug Dependence – Diphenidine – 2-Methoxydiphenidine (2-MeO-DIPHENIDINE) Forty-third report – Isotonitazene – MDMB-4en-PINACA – CUMYL-PEGACLONE – Flubromazolam – Clonazolam – Diclazepam The report also contains the critical review documents that informed recommendations made by the ECDD regarding international control of those substances. The World Health Organization was established in 1948 as a specialized agency of the United Nations serving as the directing and coordinating authority for international health matters and public health. One of WHO’s constitutional functions is to provide objective, reliable information and advice in the field of human health, a responsibility that it fulfils in part through its extensive programme of publications. The Organization seeks through its publications to support national health strategies and address the most pressing public health concerns of populations around the world.
    [Show full text]
  • Toxicology Report Division of Toxicology Daniel D
    Franklin County Forensic Science Center Office of the Coroner Anahi M. Ortiz, M.D. 2090 Frank Road Columbus, Ohio 43223 Toxicology Report Division of Toxicology Daniel D. Baker, Chief Toxicologist Casey Goodson Case # LAB-20-5315 Date report completed: January 28, 2021 A systematic toxicological analysis has been performed and the following agents were detected. Postmortem Blood: Gray Top Thoracic ELISA Screen Acetaminophen Not Detected ELISA Screen Barbiturates Not Detected ELISA Screen Benzodiazepines Not Detected ELISA Screen Benzoylecgonine Not Detected ELISA Screen Buprenorphine Not Detected ELISA Screen Cannabinoids See Confirmation ELISA Screen Fentanyl Not Detected ELISA Screen Methamphetamine Not Detected ELISA Screen Naltrexone/Naloxone Not Detected ELISA Screen Opiates Not Detected ELISA Screen Oxycodone/Oxymorphone Not Detected ELISA Screen Salicylates Not Detected ELISA Screen Tricyclics Not Detected Page 1 of 4 Casey Goodson Case # LAB-20-5315 GC/FID Ethanol Not Detected GC/MS Acidic/Neutral Drugs None Detected GC/MS Nicotine Positive GC/MS Cotinine Positive Reference Lab Delta-9-THC 13 ng/mL Reference Lab 11-Hydroxy-Delta-9-THC 1.2 ng/mL Reference Lab 11-Nor-9-Carboxy-Delta-9-THC 15 ng/mL Postmortem Urine: Gray Top Urine GC/MS Cotinine Positive This report has been verified as accurate and complete by ______________________________________ Daniel D. Baker, M.S., F-ABFT Cannabinoid quantitations in blood were performed by NMS Labs, Horsham, PA. Page 2 of 4 Casey Goodson Case # LAB-20-5315 Postmortem Toxicology Scope of Analysis Franklin County Coroner’s Office Division of Toxicology Enzyme Linked Immunosorbant Assay (ELISA) Blood Screen: Qualitative Presumptive Compounds/Classes: Acetaminophen (cut-off 10 µg/mL), Benzodiazepines (cut-off 20 ng/mL), Benzoylecgonine (cut-off 50 ng/mL), Cannabinoids (cut-off 40 ng/mL), Fentanyl (cut-off 1 ng/mL), Methamphetamine/MDMA (cut-off 50 ng/mL), Opiates (cut-off 40 ng/mL), Oxycodone/Oxymorphone (cut-off 40 ng/mL), Salicylates (50 µg/mL).
    [Show full text]
  • HIV-1 Protease Inhibitory Activity of Amprenavir –Poly(Ethylene Glycol)
    ©2014 Mahta Samizadeh ALL RIGHTS RESERVED ANTI-HIV DRUG CONJUGATES FOR ENHANCED MUCOSAL PRE-EXPOSURE PROPHYLAXIS By MAHTA SAMIZADEH A dissertation submitted to the Graduate School-New Brunswick Rutgers, The State University of New Jersey In partial fulfillment of the requirements For the degree of Doctor of Philosophy Graduate Program in Pharmaceutical Science Written under the direction of Professor Patrick J. Sinko And approved by ____________________________ ____________________________ ____________________________ ____________________________ New Brunswick, New Jersey May, 2014 ABSTRACT OF THE DISSERTATION ANTI-HIV DRUG CONJUGATES FOR ENHANCED MUCOSAL PRE-EXPOSURE PROPHYLAXIS By Mahta Samizadeh Dissertation Director: Professor Patrick J. Sinko To combat HIV pandemic, targeting HIV mucosal transmission appears to be more effective than targeting later stages of the infection owing to the viral vulnerability and higher efficacy of antiretrovirals at this very early stage of HIV infection. The objective of the current project is to investigate the complementary benefits of combining an anti-HIV drug (amprenavir, APV), a cell-penetrating peptide (bactenicin 7, Bac7 CPP) and poly (ethylene glycol) (PEG) together as a nanocarrier conjugate for fast and efficient cytosolic delivery of the drug. The nanocarrier is to be incorporated into an alcohol-free thermosensitive foam for colonic/rectal delivery. In the initial studies, APV-PEG conjugates were prepared using 2 to 30 kDa PEGs and protease inhibition properties were assessed in buffer using FRET-based protease inhibition assay. The results suggested that PEG size between 2 and 5 kDa is the optimum range for maintaining the protease inhibition activity. For further studies, APV- PEG3.4-FITC (APF) and a PEGylated APV conjugated with Bac7 CPP (APV-PEG3.4- Bac7 CPP; APB) were prepared.
    [Show full text]
  • Analysis of Oxycodone and Its Metabolites-Noroxycodone, Oxymorphone, and Noroxymorphone in Plasma by LC/MS with an Agilent ZORBAX Stablebond SB -C18 LC Column
    Analysis of Oxycodone and Its Metabolites-Noroxycodone, Oxymorphone, and Noroxymorphone in Plasma by LC/MS with an Agilent ZORBAX StableBond SB -C18 LC Column Application Note Pharmaceutical Authors Abstract Linda L. Risler Oxycodone and its oxidative metabolites (noroxycodone, oxymorphone, and Fred Hutchinson Cancer Research noroxymorphone) were analyzed by high performance liquid chromatography/mass Center, spectrometry (HPLC/MS), coupled with chromatographic separation by an Agilent Seattle, WA 98109 ZORBAX Rapid Resolution High Throughput (RRHT) StableBond SB-C18 column. The method used an ammonium acetate/acetonitrile gradient with detection by a mass Anne E. Mack spectrometer in electrospray mode with positive polarity. Spiked human plasma Agilent Technologies, Inc. samples underwent solid phase extraction (SPE) prior to LC/MS analysis. This method provided good linearity (R 2 > 0.9900) and reproducibility (< 10% difference between duplicates) for all compounds, while increasing productivity with a fast, efficient analysis and minimal solvent usage. Introduction Experimental Oxycodone was developed in 1916 as an opioid analgesic An Agilent 1100 Series LC/MS was used for this work: medication intended to replace the far too addictive analgesic at the time, heroin. Today, oxycodone is a Schedule II drug in • Agilent G1312A Binary Pump. Mobile phase A: 20 mM the US, which means, while it has proven medical uses, it is ammonium acetate, pH 4.0 and B: acetonitrile. Flow rate still considered highly addictive with the possibility of both was 0.300 mL/min. Hold 5% B for 2.33 minutes, then physical and psychological dependencies. Figure 1 shows increase B from 5% to 20% from 2.33 to 4.33 minutes, stop oxycodone and its metabolic scheme, yielding noroxycodone, time is 6 minutes, and post time is 4 minutes.
    [Show full text]
  • Benzimidazole-Opioids June 2021
    Drug Enforcement Administration Diversion Control Division Drug & Chemical Evaluation Section Benzimidazole-Opioids June 2021 Introduction: metonitazene, metodesnitazene, and protonitazene involved interaction with β-arrestin-2. Mu-opioid receptor and β-arrestin-2 Recently, several synthetic substances of benzimidazole interaction has been implicated in adverse health effects of many structural class are being trafficked and abused for their opioid- opioid analgesics. It is well established that mu-opioid receptor like effects. In the late 1950s, the pharmaceutical research agonists have a high potential for addiction and can produce dose- laboratories of the Swiss chemical company CIBA dependent respiratory depression and arrest. Abuse of these Aktiengesellschaft synthesized numerous benzimidazole- benzimidazole-opioids has led to their positive identification in opioids to include butonitazene, etodesnitazene, flunitazene, several toxicological cases in the United States. Specifically, metonitazene, metodesnitazene, and protonitazene. Since metonitazene has been identified in twenty post-mortem cases. 2019, the abuse of benzimidazole-opioids as evidenced by their identification in toxicology cases, similar to other synthetic opioids, has resulted in adverse health effects including deaths. User Population: As the United States continues to experience an unprecedented The population likely to abuse benzimidazole-opioids appears to be epidemic of opioid misuse and abuse, the continued evolution the same as those abusing prescription opioid analgesics, heroin, and increased trafficking and popularity of new and deadly and other synthetic opioid substances. This is evidenced by the synthetic opioids including benzimidazole-opioids with no types of other drugs co-identified in isotonitazene seizures and in approved medical use are of public health concern. fatal overdose cases. Toxicology analyses co-identified some of these benzimidazole-opioids with other opioids, stimulants, and Chemistry: benzodiazepines.
    [Show full text]