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Anaesthesia and Past Use Of
177 Correspondence were using LSD. It is more popular than other commonly Anaesthesia and past use of used hallucinogens whose quoted incidence of clients are: LSD ketamine 0.1% (super-K/vitamin K.I), psilocybin and psilocin 0.6% (the active alkaloids in the Mexican "magic To the Editor: mushroom"), and 3,4 methylenedioxymethamphetamine We report the case of a 43-yr-old lady who was admitted ~MDMA" 1% (ecstasy). The effects of the concurrent to the Day Surgery Unit for release of her carpal tunnel ingestion of LSD on anaesthesia are well described. 2-4 retinaculum. During the preoperative visit, she reported The long-term effects of the past use of LSD are largely no intercurrent illnesses, drug therapy or allergies. She unknown. We wonder if the hallucinations experienced did say, however, that she was frightened of general anaes- by our patient during anaesthesia were due to her LSD thesia, since she had experienced terrifying dreams during intake many years before. We would be interested to surgery under general anaesthesia on three occasions dur- know if others have had experience anaesthetising patients ing the previous ten years. On further questioning, she who are past users of phencyclidine-derived drugs. admitted that she had used lysergic acid diethylamide (LSD) during the late 1960's, the last occasion being 1968 Geoffrey N. Morris MRCGPFRCA when she had experienced characterstic hallucinations. Patrick T. Magee MSe FRCA She had not experienced hallucinations in the ensuing Anaesthetic Department years, except on the surgical occasions mentioned. Royal United Hospital One of the three previous operations had been per- Combe Park formed at our hospital and the anaesthetic record was Bath BA1 3NG checked. -
Review of Psilocybin/Psilocin Pharmacology Isaac Dehart
Review of Psilocybin/Psilocin Pharmacology Isaac DeHart Introduction Psilocybin (PY, 4-phosphoryloxy-N,N-dimethyltryptamine or O-phosphoryl-4-hydroxy- N,N-dimethyltryptamine) (Figure 1, 1) is an indolamine (Figure 1, 2), and the primary ingredient in magic mushrooms. It has been implicated as a treatment for a number of psychological ailments including depression, general anxiety disorder, various addictions, obsessive- compulsive disorder, and post-traumatic stress disorder.1–4 Because of the drug’s re-emerging relevance in clinical applications, and because of its distinctive and informative effects on brain function, it is important to understand the pharmacology and general chemistry underlying its metabolism. Psilocybin is a prodrug of psilocin Magic mushrooms, the natural source of psilocybin may refer to several different hallucination-causing fungi, but the most potent of these are found in the genus Psilocybe. When ingested, magic mushrooms cause “trips,” wherein a user experiences euphoria, colorful hallucinations, and changes in perception, cognition and mood. In the case of “bad trips,” a user may experience states of intense panic or paranoia.5,6 More generally, these trips are sometimes described in terms of psychotic states, and behavioral studies involving psilocybin have demonstrated similarities between the effects of psilocybin and schizophrenia both in subjective experience and in physiological response.7 While psilocybin is more widely known as the cause behind these effects, it is referred to by researchers as a prodrug, -
An Old Chemical That Became a New Psychoactive Substance: Study on O-Acetylpsilocin Samples Handled for Analysis and Raise of Awareness
An old chemical that became a new psychoactive substance: study on O-Acetylpsilocin samples handled for analysis and raise of awareness A. Palma1,2, L.Galindo1, Marc Grifell1,2, P. Quintana3, A. Toll1,2, M. Ventura3, I. Fornís3, M. Torrens1,2,4, M.Farré4,5, F. Fonseca1,2 1 Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, Barcelona, Spain. 2 Institut Hospital del Mar d'Investigacions Mèdiques, Parc de Salut Mar, Barcelona, Spain. 3 Asociación Bienestar y Desarrollo, Energy Control, Barcelona, Spain. 4 Universitat Autònoma de Barcelona, Barcelona, Spain. 5 Servei de Farmacología Clínica, Hospital Germans Trías i Pujol, Barcelona, Spain. Introduction Objective l New psychoactive substances (NPS) refer to emerging substances that have The aims of this study are appeared on the market and are not under international control (1). According to the m to explore the presence of 4-AcO-DMT from the samples handled to and data provided by the European Monitoring System for Drug and Drug Addiction, NPS analyzed by harm reduction service Energy Control and have experienced an unprecedented increase in number, type and availability during m to evaluate the ratio between 4-AcO-DMT and other related tryptamines the last years (2). (mushrooms, 4-AcO-DIPT, 4-AcO-MIPT and psilocybin). l Non-controlled tryptamines have psychedelic effects similar to the tryptamines already controlled such as psilocybin from Psylocybes mushrooms (3). l O-Acetylpsilocin also known as Psilacetin and 4-Acetoxy- Material and methods DMT (4-AcO-DMT) [Figure 1] is a synthetic tryptamine patented l Sample: all samples delivered for analysis from January 2009 to December in 1963 having a psychedelic effect by stimulating the 2014 were studied: serotoninergic system (3,4) and proposed as a research m handled as 4-AcO-DMT. -
Cartografiando Un Camino Para La Iboga
CARTOGRAFIANDO UN CAMINO PARA LA IBOGA Iboga Community Engagement Initiative CONCLUSIONES Y RECOMENDACIONES Marzo 2021 Un proyecto de International Center for Ethnobotanical Education, Research and Service (ICEERS) Dirección del proyecto Ricard Faura, PhD Andrea Langlois Asesoramiento científico, legal y técnico en ICEERS Benjamin De Loenen, Dr. José Carlos Bouso, Genís Ona Edición Igor Domsac Fotografía Ricard Faura Diseño gráfico Àlex Verdaguer Marzo de 2021 Para más información o consultas, por favor envíe un correo electrónico a: [email protected] www.iceers.org CARTOGRAFIANDO UN CAMINO PARA LA IBOGA Iboga Community Engagement Initiative CONCLUSIONES Y RECOMENDACIONES CONTENIDOS Conclusiones y recomendaciones 5 Introducción 7 Breve contexto: de África al mundo 9 La Iniciativa de Compromiso 10 Cómo abordar este informe 11 Agradecimientos 11 A: Comunidad, reciprocidad y curación global 14 Conclusiones 14 Recomendaciones 16 B: Regeneración biocultural y sostenibilidad 23 Conclusiones 23 Recomendaciones 27 C: Reconocimiento y evolución de los enfoques curativos tradicionales y nuevos 31 Conclusiones 31 Recomendaciones 34 Notas 38 Conclusiones y recomendaciones 5 Conclusiones y recomendaciones A: Comunidad, reciprocidad y curación global Conclusiones » Las comunidades internacionales de la iboga y de la ibogaína se beneficiarían de una mayor interconexión, comunicación y colaboración para aumentar los esfuerzos de sostenibilidad y fomentar mayores oportunidades de curación humana y planetaria. » El actual ecosistema global de la iboga está -
Fall TNP Herbals.Pptx
8/18/14 Introduc?on to Objecves Herbal Medicine ● Discuss history and role of psychedelic herbs Part II: Psychedelics, in medicine and illness. Legal Highs, and ● List herbs used as emerging legal and illicit Herbal Poisons drugs of abuse. ● Associate main plant and fungal families with Jason Schoneman RN, MS, AGCNS-BC representave poisonous compounds. The University of Texas at Aus?n ● Discuss clinical management of main toxic Schultes et al., 1992 compounds. Psychedelics Sacraments: spiritual tools or sacred medicine by non-Western cultures vs. Dangerous drugs of abuse vs. Research and clinical tools for mental and physical http://waynesword.palomar.edu/ww0703.htm disorders History History ● Shamanic divinaon ○ S;mulus for spirituality/religion http://orderofthesacredspiral.blogspot.com/2012/06/t- mckenna-on-psilocybin.html http://www.cosmicelk.net/Chukchidirections.htm 1 8/18/14 History History http://www.10zenmonkeys.com/2007/01/10/hallucinogenic- weapons-the-other-chemical-warfare/ http://rebloggy.com/post/love-music-hippie-psychedelic- woodstock http://fineartamerica.com/featured/misterio-profundo-pablo- amaringo.html History ● Psychotherapy ○ 20th century: un;l 1971 ● Recreaonal ○ S;mulus of U.S. cultural revolu;on http://qsciences.digi-info-broker.com http://www.uspharmacist.com/content/d/feature/c/38031/ http://en.wikipedia.org/nervous_system 2 8/18/14 Main Groups Main Groups Tryptamines LSD, Psilocybin, DMT, Ibogaine Other Ayahuasca, Fly agaric Phenethylamines MDMA, Mescaline, Myristicin Pseudo-hallucinogen Cannabis Dissociative -
Ce4less.Com Ce4less.Com Ce4less.Com Ce4less.Com Ce4less.Com Ce4less.Com Ce4less.Com
Hallucinogens And Dissociative Drug Use And Addiction Introduction Hallucinogens are a diverse group of drugs that cause alterations in perception, thought, or mood. This heterogeneous group has compounds with different chemical structures, different mechanisms of action, and different adverse effects. Despite their description, most hallucinogens do not consistently cause hallucinations. The drugs are more likely to cause changes in mood or in thought than actual hallucinations. Hallucinogenic substances that form naturally have been used worldwide for millennia to induce altered states for religious or spiritual purposes. While these practices still exist, the more common use of hallucinogens today involves the recreational use of synthetic hallucinogens. Hallucinogen And Dissociative Drug Toxicity Hallucinogens comprise a collection of compounds that are used to induce hallucinations or alterations of consciousness. Hallucinogens are drugs that cause alteration of visual, auditory, or tactile perceptions; they are also referred to as a class of drugs that cause alteration of thought and emotion. Hallucinogens disrupt a person’s ability to think and communicate effectively. Hallucinations are defined as false sensations that have no basis in reality: The sensory experience is not actually there. The term “hallucinogen” is slightly misleading because hallucinogens do not consistently cause hallucinations. 1 ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com How hallucinogens cause alterations in a person’s sensory experience is not entirely understood. Hallucinogens work, at least in part, by disrupting communication between neurotransmitter systems throughout the body including those that regulate sleep, hunger, sexual behavior and muscle control. Patients under the influence of hallucinogens may show a wide range of unusual and often sudden, volatile behaviors with the potential to rapidly fluctuate from a relaxed, euphoric state to one of extreme agitation and aggression. -
BOARD MEETING AGENDA Meeting Location: Portland State Office Building 800 NE Oregon Street, Portland, OR 97232 June 6-7, 2018 Updated 6.4.18
Oregon Board of Pharmacy BOARD MEETING AGENDA Meeting Location: Portland State Office Building 800 NE Oregon Street, Portland, OR 97232 June 6-7, 2018 Updated 6.4.18 The mission of the Oregon State Board of Pharmacy is to promote, preserve and protect the public health, safety and welfare by ensuring high standards in the practice of pharmacy and by regulating the quality, manufacture, sale and distribution of drugs. Wednesday, June 6, 2018 @ 8:30AM – Conference Rm A Thursday, June 7, 2018 @ 8:30AM – Conference Room A ≈ If special accommodations are needed for you to attend or participate in this Board Meeting, please contact Loretta Glenn at: (971) 673-0001. ≈ WEDNESDAY, JUNE 6, 2018 I. 8:30AM OPEN SESSION, Penny Reher, R.Ph, Presiding A. Roll Call B. Agenda Review and Approval Action Necessary II. Contested Case Deliberation pursuant to ORS 192.690(1) - Not Open to the Public III. EXECUTIVE SESSION – NOT OPEN TO THE PUBLIC, pursuant to ORS 676.175, ORS 192.660 (1) (2) (f) (k). A. Items for Consideration and Discussion: 1. Deliberation on Disciplinary Cases and Investigations 2. Personal Appearances 3. Deficiency Notifications 4. Case Review B. Employee Performance Review pursuant to ORS 192.660(2)(i). IV. OPEN SESSION - PUBLIC MAY ATTEND - At the conclusion of Executive Session, the Board may convene Open Session to begin some of the following scheduled agenda items - time permitting at approximately 3:30PM. V. Approve Consent Agenda* Action Necessary *Items listed under the consent agenda are considered to be routine agency matters and will be approved by a single motion of the Board without separate discussion. -
Update of the Generic Definition for Tryptamines
ACMD Advisory Council on the Misuse of Drugs Chair: Professor Les Iversen Secretary: Zahi Sulaiman 2nd Floor (NW), Seacole Building 2 Marsham Street London SW1P 4DF Tel: 020 7035 1121 [email protected] Norman Baker MP, Minister for Crime Prevention Home Office 2 Marsham Street London SW1P 4DF 10 June 2014 Dear Minister, In December 2013, you commissioned the ACMD to begin a regular review of generic definitions under the Misuse of Drugs Act 1971, with the aim of capturing emerging new psychoactive substances. These drugs are variants of controlled drugs and fall outside the existing scope of the Misuse of Drugs Act 1971. The ACMD has considered evidence available on tryptamines in the context of the Misuse of Drugs Act 1971 and I enclose the Advisory Council’s advice and an expanded definition for tryptamine compounds with this letter. The ACMD’s NPS Committee has firstly reviewed previous research and existing controls to identify those tryptamines now seen to evade the existing controls. The ACMD has also reviewed data provided by the Home Office’s early warning systems and networks, clinical toxicology, prevalence and neuropharmacology in arriving at the expanded generic definition. This expanded generic definition will bring drugs such as alpha-methyltryptamine (AMT) as well as 5-MeO-DALT within the scope of the Misuse of Drugs Act 1971. These are highly potent hallucinogens which act on the 5HT2A receptor, in the same way as LSD. The ACMD therefore recommends that the tryptamines covered by the proposed expanded generic definition in this report, are controlled under the Misuse of Drugs Act (1971) as Class A substances. -
Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans
molecules Review Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans Paul Cumming 1,2,* , Milan Scheidegger 3 , Dario Dornbierer 3, Mikael Palner 4,5,6 , Boris B. Quednow 3,7 and Chantal Martin-Soelch 8 1 Department of Nuclear Medicine, Bern University Hospital, CH-3010 Bern, Switzerland 2 School of Psychology and Counselling, Queensland University of Technology, Brisbane 4059, Australia 3 Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, CH-8032 Zurich, Switzerland; [email protected] (M.S.); [email protected] (D.D.); [email protected] (B.B.Q.) 4 Odense Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark; [email protected] 5 Department of Nuclear Medicine, Odense University Hospital, DK-5000 Odense, Denmark 6 Neurobiology Research Unit, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark 7 Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, CH-8058 Zurich, Switzerland 8 Department of Psychology, University of Fribourg, CH-1700 Fribourg, Switzerland; [email protected] * Correspondence: [email protected] or [email protected] Abstract: Hallucinogens are a loosely defined group of compounds including LSD, N,N- dimethyltryptamines, mescaline, psilocybin/psilocin, and 2,5-dimethoxy-4-methamphetamine (DOM), Citation: Cumming, P.; Scheidegger, which can evoke intense visual and emotional experiences. We are witnessing a renaissance of re- M.; Dornbierer, D.; Palner, M.; search interest in hallucinogens, driven by increasing awareness of their psychotherapeutic potential. Quednow, B.B.; Martin-Soelch, C. As such, we now present a narrative review of the literature on hallucinogen binding in vitro and Molecular and Functional Imaging ex vivo, and the various molecular imaging studies with positron emission tomography (PET) or Studies of Psychedelic Drug Action in single photon emission computer tomography (SPECT). -
Antrocom Journal of Anthropology ANTROCOM Journal Homepage
Antrocom Online Journal of Anthropology vol. 17. n. 1 (2021) 5-20 – ISSN 1973 – 2880 Antrocom Journal of Anthropology ANTROCOM journal homepage: http://www.antrocom.net Leshoma, the visionary plant of southern Africa Luca Pasquali 1Independent researcher e-mail <[email protected]>. keywords abstract Boophone disticha, The bulbaceous plant Boophone disticha – known mainly by the term leshoma given hallucinogens, lebollô, kia, by the Sotho ethnic group – is characterized by powerful hallucinogenic properties and is used Basotho, San, South Africa as initiatory and divinatory plant among many southern African ethnicities. Once known as the main compound of San arrow poisons, its psychoactive properties have been recognized by Western scholars only in the last 50 years, since its ritual use was strictly kept secret by its initiates. Through the analysis of the few ancient and modern ethnographic observations that have been able to bypass the wall of secrecy that envelop the use of this plant, the Sotho male initiation rite (lebollô la banna) and the use of the plant as divinatory “bioscope ” among the South African sangoma (healers) are described. As evidenced by archaeological findings, man’s relationship with this plant has lasted for at least 2000 years. The plant The plant of leshoma is botanically classified as Boophone disticha (L. f.) Herb., belonging to the Amaryllidaceae family 1. It is a bulbaceous plant, with the bulb partially protruding from the ground. Each year the leafless bulb produces a beautiful fan of leaves which often are wavy in their margins at maturity. Once the vegetative stage is over, the plant loses its leaves, and the flowering stage begin. -
Plant Powers, Poisons, and Herb Craft
PLANT POWERS, POISONS, AND HERB CRAFT BY DALE PENDELL Foreword by Gary Snyde, $21.95 US In 'Pharmako/Poeia, Dale Pendell offers a mesmerizing guide to psychoactive Alternative plants, from their pharmacological roots to the literary offshoots. "This is a Health/ book," writes Gary Snyder, "about danger: dangerous knowledge, even more Literature dangerous ignorance." Against the greater danger, ignorance, Pendell strikes a formidable blow, as he proves himself a wise and witty guide to our plant teach- ers, their powers and their poisons. "Dale Pendell reactivates the ancient connection between the bardic poet and the shaman. His Pharmako/Poeia is a litany to the secret plant allies that have always accompanied us along the alchemical trajectory that leads to a new and yet authentically archaic future." — Terence McKenna, author of True Hallucinations "Much of our life-force calls upon the plant world for support, in medicines and in foods, as both allies and teachers. Pendell provides a beautifully crafted bridge between these two worlds. The magic he shares is that the voices are spoken and heard both ways; we communicate with plants and they with us. This book is a moving and poetic presentation of this dialogue." — Dr. Alexander T. Shulgin, University of California at Berkeley, Department of Public Health "Pharmako/Poeia is an epic poem on plant humours, an abstruse alchemic treatise, an experiential narrative jigsaw puzzle, a hip and learned wild-nature reference text, a comic paean to cosmic consciousness, an ecological handbook, a dried-herb pastiche, a countercultural encyclopedia of ancient fact and lore that cuts through the present 'conservative' war-on-drugs psychobabble." - Allen Ginsberg, poet Cover design "Dale PendelFs remarkable book will make it impossible to and color work ever again underestimate the most unprepossessing plant. -
Modes of Action of Herbal Medicines and Plant Secondary Metabolites
Medicines 2015, 2, 251-286; doi:10.3390/medicines2030251 OPEN ACCESS medicines ISSN 2305-6320 www.mdpi.com/journal/medicines Review Modes of Action of Herbal Medicines and Plant Secondary Metabolites Michael Wink Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, Heidelberg D-69120, Germany; E-Mail: [email protected]; Tel.: +49-6221-544-881; Fax: +49-6221-544-884 Academic Editor: Shufeng Zhou Received: 13 August 2015 / Accepted: 31 August 2015 / Published: 8 September 2015 Abstract: Plants produce a wide diversity of secondary metabolites (SM) which serve them as defense compounds against herbivores, and other plants and microbes, but also as signal compounds. In general, SM exhibit a wide array of biological and pharmacological properties. Because of this, some plants or products isolated from them have been and are still used to treat infections, health disorders or diseases. This review provides evidence that many SM have a broad spectrum of bioactivities. They often interact with the main targets in cells, such as proteins, biomembranes or nucleic acids. Whereas some SM appear to have been optimized on a few molecular targets, such as alkaloids on receptors of neurotransmitters, others (such as phenolics and terpenoids) are less specific and attack a multitude of proteins by building hydrogen, hydrophobic and ionic bonds, thus modulating their 3D structures and in consequence their bioactivities. The main modes of action are described for the major groups of common plant secondary metabolites. The multitarget activities of many SM can explain the medical application of complex extracts from medicinal plants for more health disorders which involve several targets.