EPA/DHA and Vitamin a Supplementation Improves Spatial Memory and Alleviates the Age-Related Decrease in Hippocampal Rxrγ and Kinase Expression in Rats
fnagi-08-00103 May 5, 2016 Time: 16:44 # 1 ORIGINAL RESEARCH published: 09 May 2016 doi: 10.3389/fnagi.2016.00103 EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRg and Kinase Expression in Rats Anne Létondor1,2,3,4, Benjamin Buaud4, Carole Vaysse4, Emmanuel Richard5, Sophie Layé1,2, Véronique Pallet1,2,3† and Serge Alfos1,2,3*† 1 Université de Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France, 2 INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France, 3 Bordeaux INP, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France, 4 ITERG, Institut des Corps Gras, Pessac, France, 5 INSERM, Biothérapie des Maladies Génétiques Inflammatoires et Cancers, U1035, Bordeaux, France Edited by: Elizabeth J. Johnson, Studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and Tufts University, USA vitamin A are critical to delay aged-related cognitive decline. These nutrients regulate Reviewed by: gene expression in the brain by binding to nuclear receptors such as the retinoid Kathy R. Magnusson, X receptors (RXRs) and the retinoic acid receptors (RARs). Moreover, EPA/DHA and Oregon State University, USA Cathy W. Levenson, retinoids activate notably kinase signaling pathways such as AKT or MAPK, which Florida State University College includes ERK1/2. This suggests that these nutrients may modulate brain function in a of Medicine, USA Simon C. Dyall, similar way. Therefore, we investigated in middle-aged rats the behavioral and molecular Bournemouth University, UK effects of supplementations with EPA/DHA and vitamin A alone or combined. 18-month- *Correspondence: old rats exhibited reference and working memory deficits in the Morris water maze, Serge Alfos associated with a decrease in serum vitamin A and hippocampal EPA/DHA contents.
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