Biogeographic partitioning of Southern Ocean Formicroorganisms Peer Review revealed by metagenomics Only

Journal: Environmental Microbiology and Environmental Microbiology Reports

Manuscript ID: EMI-2012-1032.R1

Manuscript Type: EMI - Research article

Journal: Environmental Microbiology

Date Submitted by the Author: n/a

Complete List of Authors: Cavicchioli, Ricardo

ecophysiology, element cycles and biogeochemical processes, environmental , genomics/functional genomics/comparative Keywords: genomics, metagenomics/community genomics, microbial ecology, ,

Wiley-Blackwell and Society for Applied Microbiology Page 1 of 848

1 Biogeographic partitioning of Southern Ocean microorganisms

2 revealed by metagenomics

3

4 David Wilkins 1, Federico M. Lauro 1, Timothy J. Williams 1, Matthew Z. Demaere 1, Mark

5 V. Brown 1,2 , JeffreyFor M. HoffmanPeer3, Cynthia Review AndrewsPfannkoch Only3, Jeffrey B. Mcquaid 3,

6 Martin J. Riddle 4, Stephen R. Rintoul 5, Ricardo Cavicchioli 1,*

7

8 1 School of Biotechnology and Biomolecular Sciences, The University of New South Wales,

9 Sydney, New South Wales, 2052, Australia.

10 2 Evolution and Ecology Research Centre, The University of New South Wales, Sydney, New

11 South Wales, 2052, Australia.

12 3 J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD, 20850, USA.

13 4 Australian Antarctic Division, Channel Highway, Kingston, Tasmania, 7050, Australia.

14 5 CSIRO Marine and Atmospheric Research, and Centre for Australian Weather and Climate

15 Research - A partnership of the Bureau of Meteorology and CSIRO, and CSIRO Wealth from

16 Oceans National Research Flagship, and the Antarctic Climate and Ecosystems Cooperative

17 Research Centre, Castray Esplanade, Hobart, Tas, 7001, Australia.

18 * To whom correspondence should be addressed: Ricardo Cavicchioli, School of Biotechnology

19 and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Tel. (+61

20 2) 9385 3516, Fax. (+61 2) 9385 2742, E-mail. [email protected]

21

22 Running title: Biogeography of Southern Ocean microorganisms

1 Wiley-Blackwell and Society for Applied Microbiology Page 2 of 848

23 Summary

24 We performed a metagenomic survey (6.6 Gbp of 454 sequence data) of Southern Ocean

25 (SO) microorganisms during the austral summer of 2007–2008, examining the genomic

26 signatures of communities across a latitudinal transect from Hobart (44°S) to the Mertz 27 Glacier, AntarcticaFor (67°S). Peer Operational Review taxonomic units (OTUs) Only of the SAR11 and SAR116 28 and the cyanobacterial genera Prochlorococcus and Synechococcus were strongly

29 overrepresented north of the Polar Front (PF). Conversely, OTUs of the

30 Gammaproteobacterial OxidizerEOSA1 (GSOEOSA1) complex, the phyla

31 Bacteroidetes and Verrucomicrobia and order Rhodobacterales were characteristic of

32 waters south of the PF. Functions enriched south of the PF included a range of

33 transporters, sulphur reduction and histidine degradation to glutamate, while branched

34 chain amino transport, nucleic acid biosynthesis and methionine salvage were

35 overrepresented north of the PF. The taxonomic and functional characteristics suggested a

36 shift of primary production from cyanobacteria in the north to eukaryotic phytoplankton

37 in the south, and reflected the different trophic statuses of the two regions. The study

38 provides a new level of understanding about SO microbial communities, describing the

39 contrasting taxonomic and functional characteristics of microbial assemblages either side

40 of the PF.

41

42 Introduction

43

44 The SO plays a critical role in sustaining marine life around the globe. Upwelling of nutrientrich

45 Circumpolar Deep Water (CDW) returns nutrients transported to the deep ocean by the sinking

2 Wiley-Blackwell and Society for Applied Microbiology Page 3 of 848

46 of organic matter (Rath et al. , 1998) and supports 75% of global ocean primary production north

47 of 30°S. Surface waters at high southern latitudes remain cold (< 3°C) yearround but undergo

48 extreme seasonal variations in ice cover, light levels and day length. Primary production and

49 biomass are high in summer and very low in winter. Bacteria are abundant in the SO despite the 50 low temperaturesFor and seasonal Peer variability Review in productivity and are Only a major route for flow 51 (Hessen et al. , 2004).

52 The SO is composed of several zones separated by circumpolar fronts, the locations of

53 which vary temporally and with longitude (Whitworth III, 1980; Orsi et al. , 1995; Sokolov and

54 Rintoul, 2002). The fronts separate regions with different physiochemical properties, such as

55 density, salinity, temperature and nutrient concentrations (Sokolov and Rintoul, 2002).

56 Hydrographic, bathythermographic and satellite altimetry data have been used to determine the

57 frontal structure of the Antarctic Circumpolar Current (ACC) south of Australia (Sokolov and

58 Rintoul, 2002). From north to south, the major fronts are the Subtropical Front (STF), the

59 Subantarctic Front (SAF), the Polar Front (PF) and the southern ACC front (SACCF). Each of

60 these fronts consists of multiple branches (Sokolov and Rintoul, 2002; Sokolov and Rintoul,

61 2009a, b). The Subantarctic Zone (SAZ) lies between the STF and SAF, the Polar Frontal Zone

62 (PFZ) lies between the SAF and the PF, and the Antarctic Zone (AZ) lies between the PF and the

63 Antarctic continent.

64 The PF has been suggested to be a major biogeographical boundary in the distribution and

65 abundance of both zooplankton (Chiba et al. , 2001; Hunt et al. , 2001; Esper and Zonneveld,

66 2002; Ward et al. , 2003) and bacterioplankton (Selje et al. , 2004; Abell and Bowman, 2005;

67 Giebel et al. , 2009; Weber and Deutsch, 2010). However, the microbial assemblages that

68 characterize Antarctic waters are generally poorly understood, and their diversity and functional

3 Wiley-Blackwell and Society for Applied Microbiology Page 4 of 848

69 capacity are not well characterized (Murray and Grzymski, 2007; Wilkins et al., 2012). Large

70 scale metagenome surveys have not previously been performed.

71 Recent anthropogenic climate change may be driving the warming and freshening of the

72 ACC (Boning et al. , 2008) and shifting it and its fronts poleward (Fyfe and Saenko, 2005; 73 Biastoch et al. ,For 2009). A communitylevelPeer Review understanding is require Onlyd to effectively understand the 74 main components and dynamics of the microbial food web in the SO and thereby predict the

75 effects of a shifting ACC on the distribution and abundance of plankton. The oceanic changes

76 may have global ecological significance as the SO performs many ecosystem functions,

77 including significant sequestration of anthropogenic CO 2 (Sabine et al. , 2004; Mikaloff Fletcher

78 et al. , 2006) through both physiochemical processes and the “biological pump” of CO 2 fixation

79 (Thomalla et al. , 2011).

80 In the austral summer of 2006 we initiated a metagenome program based on the sampling

81 design of the Global Ocean Sampling (GOS) expedition (Rusch et al. , 2007), aimed at providing

82 a baseline to monitor microbial communities in the Australian section of the SO. To date we

83 have sampled SO water from 73° E to 150° E and 44° S to 68° S at depths from the surface to ~

84 3700 m. In this study, we present data for plankton assemblages passed through a 20 m prefilter

85 and captured onto sequential 0.1 m, 0.8 m and 3.0 m filters. This fractionation approach was

86 originally adopted by the GOS expedition (Rusch et al. , 2007) and enables deeper sequencing of

87 a greater representation of the marine microbial community thereby improving the identification

88 of lowabundance taxa. By adopting this approach the metagenome datasets generated from the

89 SO can be directly compared to available GOS data (e.g. Brown et al.,2012). In studies of the SO

90 and marine derived Antarctic lakes, the approach has also proven useful for learning about the

91 microbial ecosystem in the context of resource partitioning, including particle attachment,

4 Wiley-Blackwell and Society for Applied Microbiology Page 5 of 848

92 trophic status and virus–host interactions (Ng et al. , 2010; Lauro et al. , 2011; Yau et al. , 2011;

93 Williams et al. , 2012b).

94 The samples in our SO study were collected in summer 2007/2008 on the SR3 transect

95 (Sokolov and Rintoul, 2002) of the Climate of Antarctica and the Southern Ocean (CASO), and 96 Collaborative EastFor Antarctica Peer Marine Census Review (CEAMARC) projects Only during the International 97 Polar Year (IPY) program (Fig.1). We assessed the taxonomic and functional profiles of

98 microbial communities from either side of the PF, thereby contributing important new

99 information about the microbial ecology of the SO and defining the microbial communities most

100 influenced by the effects of the PF forming a biogeographical barrier.

101

102 Results and discussion

103

104 Overview of taxonomic biogeography

105

106 6.6 Gbp of 454 sequence data representing microorganisms in the size range 0.1 – 3.0 m was

107 obtained from 16 samples. After removal of lowquality reads, 454 sequencing yielded 157,507

108 to 597,689 reads per sample (mean 354,399) of lengths ranging from 100 to 606 bp (mean 378).

109 The proportion of reads in each sample which yielded matches to RefSeq ranged from 25% to

110 85% (mean 62%). The most abundant OTUs in each sample are given in Table 1 and a full list of

111 OTU abundances in Table S2. It is important to note that the taxonomic assignments are

112 confident assignments ( i.e. below an Evalue threshold of 1.0 × 10 3) that are limited to the

113 sequences of available in the database and identified by MINSPEC as part of the

114 minimal set.

5 Wiley-Blackwell and Society for Applied Microbiology Page 6 of 848

115 ANOSIM was performed to test for statistically significant differences between the OTU

116 profiles of the zones. The analysis showed that the zones harbor significantly different microbial

117 communities (R = 0.451, p < 0.004). SIMPER was performed in order to identify the

118 contribution of individual OTUs to the differences between the zones. The analysis found that no 119 single OTU contributedFor more Peer than 2.9% ofReview variance (Fig. 2), and Only 74% of variance was 120 contributed by OTUs with a contribution less than 1%. There was also a large difference in the

121 contribution to variance of the three size fractions, with approximately 52% of all variance

122 contributed by OTUs from 3.0 m fraction, 37% by the 0.8 m fraction, and 9% by the 0.1 m

123 fraction (Table S3, supporting information).

124 Notably, OTUs within several taxonomic groups that had high contribution to variance

125 covaried in their relative representation in the NZ and SZ. For example, Bacteroidetes and GSO

126 EOSA1 representatives were on average more abundant in the SZ; while Prochlorococcus and

127 Synechococcus spp., SAR11 and SAR116 were on average more abundant in the NZ (Fig. 2).

128 Some groups, such as the Alteromonadales, had variable relative representation depending on

129 size fraction.

130

131 GSO-EOSA-1

132

133 The Gammaproteobacterial Sulfur OxidizerEOSA1 (GSOEOSA1) cluster, represented in

134 RefSeq by the OTUs Candidatus “Vesicomyosocius okutanii” strain HA and Candidatus

135 “Ruthia magnifica” strain Cm. ( Calyptogena magnifica ) (Walsh et al. , 2009), made a large

136 contribution to variance between the NZ and SZ, with higher abundance in the SZ: relative

137 abundances of GSOEOSA1 in the SZ were 5.2%, 3.4% and 0.25% in the 0.1, 0.8 and 3.0 m

6 Wiley-Blackwell and Society for Applied Microbiology Page 7 of 848

138 size fractions respectively, compared to 1.1%, 0.84% and 0.30% in the NZ. The contribution to

139 variance of this group was highest in the 0.1 m size fraction, followed by 0.8 m and 3.0 m

140 (Fig. 2). This pattern most likely represents a small size and lack of association with

141 particulate matter. 142 Ca. “R. magnifica”For and Peer Ca. “V. okutanii” Review are chemoautotrophic Only endosymbionts of deepsea 143 bivalves (Kuwahara et al. , 2007; Newton et al. , 2007) and are thus unlikely to be present in open

144 ocean surface waters. However, GSOEOSA1 representative ARCTIC96BD19 has recently

145 been reported at high abundance in Antarctic coastal waters (Ghiglione and Murray, 2011;

146 Grzymski et al. , 2012). The majority of 16S rRNA genes from our metagenome with best

147 BLASTN matches to Ca. “R. magnifica” and Ca. “V. okutanii” clustered with ARTIC96BD19 in

148 a neighbourjoining (Fig. S1, supporting information), indicating this is the

149 dominant GSOEOSA1 representative. Singlecell genomic analysis of ARCTIC96BD19 from

150 global mesopelagic waters indicates the lineage is probably mixotrophic, able to couple carbon

151 fixation to oxidation of reduced sulphur compounds as well as assimilate organic carbon (Swan

152 et al. , 2011). GSOEOSA1 cytochrome C oxidase (CoxII) has been identified in a winter

153 metaproteome of Antarctic Peninsula coastal waters, suggesting the capacity for aerobic

154 respiration (Williams et al. , 2012a). We assembled our GSOEOSA1 affiliated reads and

155 identified several contigs containing ORFs with high identity to aerobic respiration genes,

156 including cytochrome C oxidase subunits, from Ca. “R. magnifica” and Ca. “V. okutanii” (Fig.

157 S2, supporting information). Taken together, this evidence suggests the GSOEOSA1

158 representative in Antarctic coastal waters is a versatile chemolithoautotroph capable of aerobic

159 respiration.

7 Wiley-Blackwell and Society for Applied Microbiology Page 8 of 848

160 It has been proposed that during the winter months, chemolithoautotrophy is dominant over

161 photoautotrophy as the major carbon fixation input in AZ waters due to the lack of available

162 light, both from seasonal darkness and ice cover (Grzymski et al. , 2012). The high relative

163 abundance of GSOEOSA1 we detected in SZ compared to NZ waters may therefore represent 164 the remnants ofFor an annual Peerwinter increase Review in population in the marginal Only ice zone which does not 165 occur in the open ocean.

166

167 Ammonia-oxidizing

168

169 Nitrosopumilus maritimus SCM1 and Cenarchaeum symbiosum are chemolithoautotrophic,

170 nitrifying members of the Marine Group I Crenarchaeota (MGI) (Preston et al. , 1996; Walker et

171 al. , 2010) and are the only representatives in the reference database of the Ammonia Oxidizing

172 Archaea (AOA). The contribution of OTUs of C. symbiosum to the AOA signature was low

173 (Table S3, supporting information). As C. symbiosum is a sponge symbiont (Preston et al. , 1996)

174 and given the poor representation of AOA in RefSeq, it is likely this OTU has attracted

175 sequences originating from planktonic AOA and C. symbiosum itself is not present. AOA were

176 moderate contributors to variance between the NZ and SZ, and were overrepresented in the SZ in

177 all size fractions (Fig. 2). As with the GSOEOSA1 cluster, MGI have been proposed to be

178 abundant chemolithoautotrophs and therefore major drivers of winter carbon fixation in

179 Antarctic coastal waters (Grzymski et al. , 2012; Williams et al. , 2012a).

180 Sample 353 had a particularly high relative abundance of N. maritimus OTUs (7.5% of the

181 0.1 m fraction; 0.8 m: 11%; 3.0 m: 12%). This sample was taken closer to the Antarctic

182 continent (3.7 km) than any other, in relatively shallow (180 m) waters 17.6 km from the Mertz

8 Wiley-Blackwell and Society for Applied Microbiology Page 9 of 848

183 Glacier. The high abundance of ammonia oxidizers may reflect an input of ammonia from

184 terrestrial sources ( e.g. penguin guano), or resuspension of benthic sediments in which MGI are

185 abundant (Bowman and McCuaig, 2003) by nearshore turbulence and iceberg scouring.

186 Breakdown of water column stratification has been previously suggested as a cause of increased 187 AOA abundanceFor in Antarctic Peer coastal surface Review waters (Kalanetra etOnly al. , 2009). 188

189 Cyanobacteria

190

191 OTUs of the cyanobacterial genera Prochlorococcus and Synechococcus were overrepresented in

192 the NZ in all size fractions (Fig. 3). The mean relative abundance of cyanobacteria in samples

193 367 and 368, the two northernmost samples, was strikingly higher than the mean abundance

194 across all other samples in the NZ. Synechococcus sp. CC9902 alone composed greater than 22%

195 of the 0.8 m fraction in these samples (Table S2, supporting information), consistent with

196 Synechococcus species’ average cell diameter of approximately 0.9 m.The high abundance of

197 both cyanobacterial genera on the 3.0 m fraction has previously been reported (Lauro et al. ,

198 2011) and may be attributable to aggregation (Lomas and Moran, 2011). In view of the

199 robustness of the sequential size fractionation method (Rusch et al. , 2007; Ng et al. , 2010; Lauro

200 et al. , 2011; Yau et al. , 2011; Williams et al. , 2012b) the size partitioning of cyanobacteria

201 indicates that a range of sizes ( e.g. aggregates) are present in the SO.

202 Samples 367 and 368 were separated from the other samples north of the PF by the

203 Subtropical Front (STF). While the STF was not a significant boundary on the assemblage level,

204 it may mark a significant biogeographical boundary for these cyanobacteria. Synechococcus and

205 Prochlorococcus together represent a large proportion of both phytoplankton abundance and

9 Wiley-Blackwell and Society for Applied Microbiology Page 10 of 848

206 carbon fixation in temperate and tropical waters, in many regions contributing more than half of

207 total primary production (Liu et al. , 1997; Liu et al. , 1998; André et al. , 1999). The role of the

208 STF in determining the latitudinal range of Synechococcus and Prochlorococcus is therefore

209 important, as it will affect models of ocean productivity under changing climactic conditions, 210 and warrants furtherFor investigation. Peer Despite Review the high abundance ofOnly cyanobacteria north of the 211 STZ, they were also a significant feature of the SAZ; for example, Synechococcus sp. CC9902

212 composed 3–5% of the 0.8 m fraction in SAZ samples. Our results extend the latitudinal

213 distribution of both Prochlorococcus and Synechococcus to include presence at very low

214 abundance as far south as the Antarctic coast. Prochlorococcus have been reported to be

215 restricted to tropical and subtropical waters within 40º of latitude (Partensky et al. , 1999), and to

216 be a negligible (Ghiglione and Murray, 2011) or undetectable (Gryzymski et al., 2012)

217 component of marine picoplankton in Antarctic waters. However, our findings are consistent

218 with findings of a logarithmic relationship of cyanobacterial numbers with temperature, where

219 cyanobacteria were found at concentrations of 10 3 – 10 4 cells per litre even in the coldest waters,

220 approximately four orders of magnitude less than in waters around Tasmania (Marchant et al. ,

221 1987). Cyanophage proteins have also been detected in a metaproteomic analysis of Antarctic

222 Peninsula coastal surface waters (Williams et al., 2012a). The depth of shotgun metagenome

223 sequence coverage of our samples is likely to have contributed to the detection of these

224 cyanobacteria.

225

226 SAR11 and SAR116 clades

227

10 Wiley-Blackwell and Society for Applied Microbiology Page 11 of 848

228 Candidatus “Pelagibacter ubique” HTCC1062 is a good representative of total SAR11

229 abundance in our study, as it is a member of the SAR11 phylotype which is most abundant in SO

230 waters (Brown et al. , 2012). Ca. “P. ubique” HTCC1062 was the most abundant OTU across all

231 samples and fractions (NZ average: 62%, 25% and 24% of the 0.1 m, 0.8 m and 3.0 m 232 fractions respectively;For SZ: Peer 59%, 22% and Review 18%) and one of the mostOnly significant contributors to 233 variance between the NZ and SZ. The high abundance of SAR11 in the 0.1 m fraction is

234 consistent with the small size of SAR11 cells (Rappé et al. , 2002). The higher representation in

235 the NZ may reflect the competitiveness of SAR11 members in regions with low DOC

236 concentrations due to low primary productivity (Giovannoni et al. , 2005; Alonso and Pernthaler,

237 2006), such as the highnutrient, lowchlorophyll (HNLC) SAZ region of the SO. Overall, our

238 findings are consistent with reports that SAR11 is ubiquitous in the world’s oceans ( e.g. Mary et

239 al., 2006; Carlson et al., 2009) and more abundant north of the ACC (Giebel et al. , 2009).

240 OTUs of Candidatus “Puniceispirillum marinum” from the SAR116 were a moderate

241 contributor to variance between the NZ and SZ with higher abundance in the NZ (Fig. 2). A

242 genomic analysis reported Ca. “P. marinum” IMCC1322 to be a metabolic generalist with genes

243 for aerobic CO fixation, C 1 and a Ca. “P. ubique”like dimethylsulfoniopropionate

244 (DMSP) demethylase, suggesting SAR116 and SAR11 occupy similar ecological niches (Oh et

245 al. , 2010). In the Scotia Sea, SAR116 abundance (determined using fluorescence in situ

246 hybridisation) was reported to be higher in more productive waters where SAR11 numbers were

247 lower (Topping et al. , 2006). However, our analysis across an extended latitudinal transect

248 indicates that overall SAR11 and SAR116 have similar biogeographic distributions.

249

250 Bacteroidetes

11 Wiley-Blackwell and Society for Applied Microbiology Page 12 of 848

251

252 OTUs of the Bacteroidetes, in particular members of the class Flavobacteria, were found

253 to be abundant (NZ average: 1.2%, 5.0% and 6.9% of the 0.1 m, 0.8 m and 3.0 m fractions

254 respectively; SZ: 2.3%, 9.8% and 9.1%) and significant contributors to variance between the NZ 255 and SZ (Fig. 2).For Flavobacteria Peer have been Reviewpreviously reported to composeOnly the majority of both 256 Bacteroidetes (Murray and Grzymski, 2007) and total planktonic biomass (Abell and Bowman,

257 2005) in the SO, as well as being abundant in sea ice (Brown and Bowman, 2001). As

258 heterotrophic degraders of High Molecular Weight (HMW) compounds in the form of both

259 Dissolved and Particulate Organic Matter (DOM and POM) (Kirchman, 2002), marine

260 Flavobacteria are major components of marine aggregates (Rath et al. , 1998; Crump et al. , 1999;

261 Zhang et al. , 2007). The higher abundance of Flavobacteria OTUs on the 0.8 m and 3.0 m

262 fractions indicates their association with particulate matter. Size partitioning of SO Flavobacteria

263 has previously been reported (Abell and Bowman, 2005), and the ecophysiology of planktonic

264 cells captured on 0.1 m filters has been described using metagenomics and metaproteomics

265 (Williams et al. , 2012b).

266 The higher abundance of OTUs of Flavobacteria in the SZ may reflect an input of cells from

267 melting sea ice (Brown and Bowman, 2001), the higher rates of primary productivity in the

268 south, and the role of the Flavobacteria as degraders of HMW DOM. Because deposition of

269 marine snow is a major route for sequestration of fixed carbon in the ocean ( e.g. Hessen et al.,

270 2004), the Flavobacteria that associate with this particulate matter represent a remineralizing

271 shunt, which would decrease carbon sequestration by this route.

272

273 Rhodobacterales

12 Wiley-Blackwell and Society for Applied Microbiology Page 13 of 848

274

275 Members of the order Rhodobacterales were abundant (NZ average: 1.2%, 10% and 5.5% of the

276 0.1 m, 0.8 m and 3.0 m fractions respectively; SZ: 1.6%, 13% and 7.9%) and high

277 contributors to variance, overrepresented in the SZ on all size fractions. As several members of 278 the RoseobacterFor clade have Peer been shown toReview have symbiotic relationships Only with marine eukaryotic 279 algae (Buchan and Moran, 2005; WagnerDobler and Biebl, 2006), and their abundance in the

280 SO has previously been linked to phytoplankton blooms (West et al. , 2008; Obernosterer et al. ,

281 2011), it is likely that their overrepresentation in the SZ is related to the higher density of

282 phytoplankton in the AZ.

283 OTUs of Roseobacter denitrificans Och114 and Silicibacter pomeroyi DSS3 were

284 consistently the most abundant Roseobacter clade representatives. R. denitrificans and S.

285 pomeroyi fall within a subclade of Aerobic Anoxygenic Phototrophic (AAP) members of the

286 Roseobacter clade (Swingley et al. , 2007). These species have diverse mixotrophic ,

287 with genomic and experimental evidence of photoheterotrophic respiration of organic carbon,

288 fixation of CO 2, oxidation of CO, oxidation of reduced sulfur compounds, and utilization of the

289 abundant marine osmolyte DMSP (King, 2003; Moran et al. , 2004; WagnerDobler and Biebl,

290 2006; Swingley et al. , 2007; Brinkhoff et al. , 2008; Howard et al. , 2008). This metabolic

291 diversity suggests a complex ecological role, particularly with respect to the capture and release

292 of climatically active gases (CO 2, CO, dimethylsulfide) involved in carbon and sulfur cycling.

293

294 Alteromonadales

295

13 Wiley-Blackwell and Society for Applied Microbiology Page 14 of 848

296 Members of the gammaproteobacterial order Alteromonadales were large contributors to

297 variance. Most OTUs were overrepresented in the SZ but some were overrepresented in the NZ

298 on the 3.0 m fraction (Fig. 2). Colwellia psychrerythraea 34H was one of the most abundant

299 OTUs in the Alteromonadales that exhibited this distribution (NZ average: 0.14%, 2.2% and 300 16% of the 0.1For m, 0.8 m Peer and 3.0 m fractionsReview respectively; SZ: Only 0.52%, 5.1% and 10%). C. 301 psychrerythraea 34H was isolated from Arctic sediment, grows well at low temperatures and

302 secretes extracellular polysaccharides (Huston et al. , 2000; Junge et al., 2003; Methé et al. ,

303 2005). Similar to other Colwellia species grown under laboratory conditions, cells have widths of

304 0.4–0.8 m and lengths of 1.5–4.5 m (Jung et al. , 2006). Growth temperature can have a major

305 impact on cell morphology, secretion and global gene expression in psychrophiles ( e.g.

306 Feller and Gerday, 2003; Junge et al. , 2003; Williams et al., 2011; Cavicchioli, 2006;

307 Campanaro et al.,2011). Moreover, marine bacteria can alter their cell dimensions in response to

308 nutrient flux, e.g. the copiotroph Photobacterium angustum undergoes reductive cell division

309 (Kjelleberg et al. , 1987; Lauro et al. , 2009). It is therefore possible that the populations of

310 Alteromonadales captured on the 3.0 m filters (overrepresented in the NZ) had different

311 physiological properties to those on the 0.1 and 0.8 m filters (overrepresented in the SZ). In this

312 regard it is noteworthy that biogeographical differences in phylotypes within the SAR11 clade

313 have been shown to correlate with environmental temperature (Brown et al. , 2012).

314

315 Verrucomicrobia

316

317 Two representatives of the phylum Verrucomicrobia, Coraliomargarita akajimensis and

318 Akkermansia sp. Muc30, were moderate contributors to variance and overrepresented in the SZ

14 Wiley-Blackwell and Society for Applied Microbiology Page 15 of 848

319 (Fig. 2). Surprisingly given the small cell size of C. akajimensis (Yoon et al. , 2007), contribution

320 to variance increased with size fraction; a global survey reported a similar fractionation pattern,

321 and suggested marine Verrucomicrobia may be predominantly particle attached (Freitas et al. ,

322 2012). However, little else is known about the distribution and ecological roles of marine 323 VerrucomicrobiaFor (Freitas etPeer al. , 2012). Review Only 324

325 Overview of functional biogeography

326

327 ANOSIM analysis of the samples’ KEGG ortholog group and module profiles revealed that the

328 zones had significantly different functional potential (ortholog group: R = 0.642, p < 0.001;

329 module: R = 0.871, p < 0.001). SIMPER was performed on the profiles in order to identify the

330 specific functional differences between the zones. No single ortholog group or module

331 contributed more than 2.2% of the variance, indicating a complex and diverse pattern of

332 functional differences (Table S4 and Table S5, supporting information). There was a strong trend

333 for ortholog groups and modules with higher contributions to variance to be overrepresented in

334 the NZ in the 3.0 m fraction but the SZ in the smaller fractions, indicating that the functional

335 diversity of each zone was strongly segregated by size fraction.

336 It is important to note that these results reflect only genomically encoded functional

337 potential, not differences in the levels of gene products. In particular, over or underrepresented

338 functions reflect differences in the taxa present and their adaptation to the different zones, rather

339 than biogeographic differences in gene regulation. These genetic differences may also reflect

340 withinpopulation selection, such as the dominance of fitter strains or ecotypes (see for example

341 Brown et al ., 2012).

15 Wiley-Blackwell and Society for Applied Microbiology Page 16 of 848

342

343 Functional capacities distinguished by the PF

344

345 A number of modules with transport functions (snglycerol 3phosphate transport system, 346 dipeptide transportFor system, Peer peptides/nickel Review transport system, simple Only sugar transport system, 347 sulfonate/nitrate/taurine transport system) were overrepresented in the SZ (Table 2 and S6). As

348 the of copiotrophic bacteria have evolved to have a higher number of narrow

349 specificity transporters relative to oligotrophic genomes (Lauro et al. , 2009), these differences

350 may reflect the higher nutrient availability and thus a dominance of copiotrophs in the SZ. The

351 taxonomic contributors to these modules were varied, although members of the Rhodobacterales

352 were prominent (Fig. 3). The glycine betaine/proline transport module was also overrepresented

353 in the SZ, though this probably reflects glycine betaine’s role as an osmo and cryoprotectant in

354 the colder SZ waters. This is supported by the major taxonomic contributor to this module, genus

355 Psychromonas , which includes several psychrophilic species.

356 One exception to this pattern was the branchedchain transport system module,

357 overrepresented in the NZ. The genera Pelagibacter and Puniceispirillum were major

358 contributors to this module’s overabundance in the NZ (Fig. 3). As both SAR11 (Giovannoni et

359 al. , 2005) and SAR116 (Grote et al. , 2011) representatives encode branchedchain amino acid

360 transporters, the abundance of this module is likely to represent taxonomic differences between

361 the zones.

362 Biosynthesis pathways for all major nucleic (pyrimidine deoxyribonuleotide

363 biosynthesis, adenine nucleotide biosynthesis, guanine nucleotide biosynthesis) were consistently

364 high contributors to variance and overabundant in the NZ. This pattern seems inconsistent with

16 Wiley-Blackwell and Society for Applied Microbiology Page 17 of 848

365 the more oligotrophic nature of the NZ, as oligotrophic cells generally have smaller genomes

366 (Lauro et al. , 2009) and slower growth rates than copiotrophs, and would therefore be expected

367 to require a lower rate of de novo nucleotide biosynthesis. A possible explanation for this is that

368 SZ cells have higher availability of extracellular DNA as a byproduct of decaying phytoplankton 369 (Lomas and Moran,For 2011), Peer which can be importedReview and salvaged forOnly nucleic acids (Pop et al. , 370 2004) thus reducing the requirement for de novo synthesis. No single taxonomic group

371 contributed a large fraction of the difference in this module (Fig. 3), suggesting this is a

372 widespread adaptation.

373 The methionine salvage pathway module had a large contribution to variance between the

374 zones and was overrepresented north of the PF. This may reflect the higher availability of

375 dimethylsulphoniopropionate (DMSP) in the SZ as a byproduct of blooming eukaryotic algae.

376 DMSP is a major carbon and sulfur source for marine microorganisms, and is commonly

377 assimilated by bacteria through demethylation to methylmercaptopropionate (MMPA), followed

378 by further catabolism to the climatically important dimethylsulfide or methanethiol (reviewed by

379 Curson et al., 2011). However, when DMSP is scarce, MMPA may be derived from methionine

380 through the alternative methionine salvage pathway (Reisch et al. , 2011). The genus

381 Synechococcus , a noted contributor to marine DMSP uptake and assimilation (VilaCosta et al. ,

382 2006), was a very high contributor to the abundance of this module in the NZ (Fig. 3), suggesting

383 Synechococcus species may use this route when DMSP is unavailable.

384 The sulfur reduction module was overrepresented in the SZ, and it is likely that this result is

385 strongly driven by taxonomic differences. While the taxonomic breakdown indicated a large

386 number of genera contributed to the difference, the gammaproteobacteria were the highest

387 contributing class (Fig. 3). This module also includes the assimilatory sulfate reduction pathway,

17 Wiley-Blackwell and Society for Applied Microbiology Page 18 of 848

388 which is widespread in marine bacteria, but is absent from SAR11, with known representatives

389 reported to lack genes for assimilatory sulfate reduction ( cysDNCHIJ ) (Tripp et al. , 2008). The

390 higher relative abundance of SAR11 in the NZ may therefore contribute to the lower abundance

391 of genes for assimilatory sulfate reduction in that zone. 392 The sulfurFor reduction modulePeer also included Review adenylylsulfate reductaseOnly (APS reductase, 393 encoded by aprAB ), an enzyme implicated in sulfite detoxification during heterotrophic growth

394 on organosulfonates (Meyer and Kuever, 2007) (N.B. in recent KEGG releases, aprA is no

395 longer included in this module). As the GSOEOSA1 representative SUP05 has been found to

396 encode APS reductase, the overabundance of this module may reflect sulfur oxidation through

397 the reverse dissimilatory sulfate reduction pathway (Walsh et al. , 2009). Also, Roseobacter clade

398 bacteria are involved in the decomposition of abundant organic sulfur compounds ( e.g ., DMSP,

399 organosulfonates), and hence have been accorded an important role in marine sulfur cycling

400 (Moran et al. , 2007).

401 The photosystem II module was overrepresented in the NZ. Given the underrepresentation

402 of cyanobacterial OTUs in the SZ, this may reflect a dominance of primary production by

403 eukaryotic algae south of the PF and cyanobacteria to the north. Decomposition of the taxonomic

404 affiliations of ortholog groups contributing to this module found OTUs of Synechococcus and

405 Prochlorococcus to be major contributors to the difference (Fig. 3). Variation in the photosystem

406 I module, which was marginally overrepresented in the SZ, could largely be attributed to diatoms

407 and other eukaryotic phytoplankton (Fig. 3), again supporting a dominance of eukaryotic

408 phytoplankton in SZ primary production. Diatoms have previously been reported at higher

409 abundance south of the PF, and their distribution is likely to be linked to the higher concentration

410 of dissolved silica in that region (Trull et al. , 2001). As both eukaryotic phytoplankton and

18 Wiley-Blackwell and Society for Applied Microbiology Page 19 of 848

411 cyanobacteria would be expected to encode both complete photosystems, the differences in

412 module abundance probably reflect the degree of similarity between the photosystem I and II

413 genes in the KEGG database and those found in the sampled environments.

414 The histidine degradation to glutamate module, which comprises four ortholog groups 415 mediating the degradationFor Peerof histidine to glutamateReview via Nformiminoglutamate, Only was 416 overrepresented in the SZ. The histidine biosynthesis module was also overrepresented in the SZ.

417 While the concentration of dissolved histidine in the SO is generally low (Kawahata and

418 Ishizuka, 2000), blooming eukaryotic phytoplankton (which are more prevalent in the SZ) may

419 deplete nitrate while releasing DFAA. As DFAA become available, they are used by bacteria to

420 sense the decaying bloom. Histidine may therefore act as a proxy for DFAA to regulate the

421 expression of bacterial aminopeptidases, which are involved in lysing diatoms (Bidle and Azam,

422 2001). The class Bacteroidetes, while a small contributor to the histidine biosynthesis module in

423 the SZ, was a large contributor to histidine degradation (Fig. 3), supporting an association

424 between Bacteroidetes and phytoplanktonic bloom products. It is also possible that uptake and

425 degradation of histidine to glutamate (which generates ammonia as a byproduct) may function

426 as a limited nitrogen source.

427

428 Biogeographic role of the PF

429

430 Our results show that there are major taxonomic and functional differences across the PF. The

431 differences in functional potential between the NZ and SZ reflect both their taxonomic profiles

432 and fundamental trophic and ecological differences. In particular, they provide genomic support

433 that the NZ is more oligotrophic than the SZ (Pollard et al. , 2002; Giovannoni et al. , 2005;

19 Wiley-Blackwell and Society for Applied Microbiology Page 20 of 848

434 Alonso and Pernthaler, 2006; Lauro et al. , 2009), and are consistent with the observation that

435 primary production is higher south of the PF (Strutton et al. , 2000; Williams et al. , 2010). Our

436 findings extend previous work in defining the PF as a strong biogeographic boundary which

437 shapes not only the composition, but also the functional capacity of microbial communities in the 438 SO. For Peer Review Only 439 A possible alternative hypothesis for the observed separation is that the samples are

440 partitioned by the continental margin, as all but one of the SZ samples were taken in waters over

441 the Antarctic continental shelf and slope in the vicinity of the Mertz glacier polynya. However,

442 ANOSIM analysis of an alternative grouping of the samples into “polynya” and “open ocean”

443 had poorer support (R = 0.309, p < 0.01) than the grouping based on the PF. Additional

444 taxonomic profiles for samples taken from the region south of the PF in other seasons (austral

445 summers 06/07, 08/09) and in other sectors of the SO (70–115° E) also supported the PF as the

446 major discriminator (data not shown). Taken together, this evidence strongly supports the

447 hypothesis that the PF is a major biogeographical boundary in the SO independent of a

448 latitudinal gradient or of the effect of the continental margin and Mertz polynya.

449 These results do not exclude the possibility that other major SO fronts, particularly the STF

450 and SAF, are also significant biogeographic boundaries, as has been reported in some previous

451 reports for specific taxonomic groups ( e.g. Abell and Bowman, 2005). While the sampling

452 resolution in this study was not sufficient to resolve the effects of other fronts, there are some

453 indications in the data of further structure within the zones. The two samples north of the STF

454 had significantly larger cyanobacterial populations than the remaining NZ samples (see

455 discussion of Prochlorococcus and Synechococcus , above). Future sampling across these fronts

456 at higher resolution will provide the data necessary to investigate finer biogeographic patterns.

20 Wiley-Blackwell and Society for Applied Microbiology Page 21 of 848

457 The nature and function of microbial communities in the SO are of global significance

458 because of the large oceanic expanse that is involved and the importance of the carbon fixation

459 and nutrient cycling that occurs there. Knowledge of these communities and their biogeographic

460 drivers has relevance for understanding and predicting the longterm effects of environmental 461 change in the region.For Our findingsPeer provide Review a basis for predicting Onlyhow climate changedriven 462 shifts in the SO may affect microbial communities; in particular, the effects of changes in the

463 nature and location of the ACC on the ecosystem functions of SO microorganisms.

464

465 Experimental procedures

466

467 Sampling and DNA sequencing

468

469 A volume of ~ 500 L per sample was collected by sequential size fractionation through a 20 m

470 prefilter directly onto 3.0, 0.8 and 0.1 m pore sized 293 mm polyethersulfone membrane filters,

471 and cryogenically preserved (Rusch et al. , 2007; Ng et al. , 2010). DNA extraction (Rusch et al. ,

472 2007) and pyrosequencing on GS20 FLX Titanium (Roche, Branford, CT, USA) was performed

473 at the J. Craig Venter Institute in Rockville, MD, USA as described previously (Lauro et al. ,

474 2011; Brown et al., 2012). Duplicate reads and reads with many pyrosequencing errors were

475 removed as described previously (Lauro et al. , 2011).

476

477 Grouping of samples by oceanographic zone

478

21 Wiley-Blackwell and Society for Applied Microbiology Page 22 of 848

479 A range of data were recorded on board the RSV Aurora Australis , including position, sampling

480 and water column depth, ocean temperature, salinity and fluorescence, and meteorological data

481 (Table S1, supporting information). These were used to locate the PFZ based on a surface

482 temperature gradient ~ 1.35 oC across a distance of 45–65 km, placing the PF at approximately 483 −59.70°, consistentFor with previousPeer descriptions Review (Moore et al. , 1999; Only Sokolov and Rintoul, 2002). 484 Samples were accordingly grouped into “North” (NZ) and “South” (SZ) zones (Table S1,

485 supporting information). The NZ represents waters from Subtropical, Subantarctic and Polar

486 Frontal Zones, while the SZ represents the AZ.

487

488 Comparison to RefSeq database

489

490 A subset of the RefSeq microbial (bacteria and archaea) database (release 41, retrieved

491 May 31 2010 from ftp://ftp.ncbi.nih.gov/refseq/release/) was prepared by excluding sequences

492 with the words “shotgun”, “contig”, “partial”, “end” or “part” in their headers (Angly et al. ,

493 2009). Because this database was not expected to contain representative genomes for every

494 species present, Operational Taxonomic Units (OTUs) in this study are defined by the best

495 species match in this database, and may for example represent congeners.

496 The metagenomic reads from each sample were compared against this database using

3 497 TBLASTX , with default parameters except for: Evalue threshold [e] 1.0 × 10 ; cost to open gap

498 [G] 11; cost to extend gap [E] 1; masking of query sequence [F] m S (SEG masking for lookup

499 table only).

500

501 Identification of minimal species sets

22 Wiley-Blackwell and Society for Applied Microbiology Page 23 of 848

502

503 A computational method to minimise false OTU identifications and increase the accuracy of

504 OTU abundance estimates ( MINSPEC ) was developed and implemented in PERL . Following the

505 approach of Ye and Doak (2009) to the parsimonious reconstruction of biochemical pathways 506 (MIN PATH ), MINSPECFor computes Peer the smallest Review set of OTUs sufficient Only to explain a set of observed 507 highquality hits against RefSeq (or any other sequence database). The minimal set computation

508 is framed as a linear programming problem and solved with the GNU Linear Programming Kit

509 (GLPK ) tool “GLPK linear programming/MIP solver” ( GLPSOL ) (Free Software Foundation,

510 Boston). This approach eliminates many of the spurious OTU identifications which result from

511 reads with strong identity to more than one OTU. The “minimal species set” is liable to exclude

512 some lowabundance OTUs, but gives more faithful abundance estimates and eliminates many

513 false positives.

514 To validate this approach and estimate error rates, an assemblage of hypothetical taxa was

515 simulated with varying degrees of overlapping genomic identity and a logarithmic rank

516 abundance curve. A simulated metagenomic sampling and BLAST search was performed on this

517 set, and the results processed with MINSPEC . Over multiple replications, MINSPEC was

518 consistently able to identify the true set and reject spurious identifications, with false positive

519 and negative rates smaller than 5% (excluding unsampled rare taxa).

520 The outputs of all TBLASTX searches against RefSeq were processed by MINSPEC , and hits

521 not belonging to the minimal sets were removed.

522

523 OTU abundance and variance between zones

524

23 Wiley-Blackwell and Society for Applied Microbiology Page 24 of 848

525 The relative OTU abundances for each sample were determined using the PERL script Genome

526 relative Abundance and Average Size ( GAAS ) (Angly et al. , 2009). Briefly, GAAS estimates the

527 relative abundance of OTUs from the number and quality of BLAST hits to each species, taking

528 into account differences in genome size. GAAS was run with the default settings. To normalise for 529 reads which didFor not yield acceptablePeer hits, Reviewthe relative abundances Only for each sample were scaled by 530 that sample’s effective BLAST hit rate. An OTU profile was generated for each sample by

531 encoding the scaled relative abundance of each OTU from each size fraction as a separate

532 variable.

533 To test the hypothesis that the oceanic zones harbour significantly different communities,

534 oneway Analysis Of SIMilarities (ANOSIM) with 999 permutations was performed on a

535 standardised, logtransformed BrayCurtis resemblance matrix of OTU profiles with PRIMER 6.

536 SIMilarity PERcentages (SIMPER) analysis was performed with PRIMER 6 to identify the

537 contribution of individual OTUs to differences between the zones. All statistical procedures

538 using PRIMER 6 were performed as described by Clarke and Warwick (2001).

539

540 Assembly of GSO-EOSA-1 contigs

541

542 To investigate the physiological potential of the GSOEOSA representative identified in the SZ,

543 reads with identity to Ca. “R. magnifica” and/or Ca. “V. okutanii” were assembled using the

544 Celera WGS Assembler v6.1 (Myers, 2000). 242 large (> 2 kbp) contigs were used for ORF

545 prediction by MetaGene (Noguchi et al. , 2006), and predicted ORFs compared against the NCBI

3 546 nr database with BLASTX (Evalue threshold [e] 1.0 × 10 ). The resulting annotated contigs were

547 manually analysed for genes of interest.

24 Wiley-Blackwell and Society for Applied Microbiology Page 25 of 848

548

549 Comparison to KEGG database

550

551 In order to identify functional differences between the zones, the set of metagenomic reads from 552 each sample wasFor compared Peer against the Kyoto Review Encyclopedia of GenesOnly and Genomes (KEGG) 553 GENES database (retrieved July 2 2010 from

554 ftp://ftp.genome.jp/pub/kegg/genes/fasta/genes.pep) with BLASTX , with default parameters except

555 for: maximum number of database sequence alignments [b] 10; Evalue threshold [e] 1.0 × 10

556 3; gap opening penalty [G] 11; gap extension penalty [E] 1; masking of query sequence [F] m

557 S (SEG masking for lookup table only).

558

559 Analysis of functional potential

560

561 Genes identified by BLASTX were aggregated to KEGG ortholog groups according to the KEGG

562 Orthology schema (ftp://ftp.genome.jp/pub/kegg/genes/ko, retrieved Mar 29 2011), and ortholog

563 group abundances calculated for each sample. Following Coleman and Chisholm (2010), a read

564 was considered a hit to a given ortholog group if the top three hits for that read (or all hits if

565 fewer than three total hits) were to genes from the same ortholog group, and had bit scores > 40.

566 If the bit score difference between any two top hits was greater than 30, only the hits above this

567 difference were considered.

568 Ortholog group counts were then used to calculate the abundance of KEGG modules.

569 Because many ortholog groups are members of more than one module, the abundance ( am) of

570 each module m was calculated as

25 Wiley-Blackwell and Society for Applied Microbiology Page 26 of 848

) ̽ ͕( Ɣ ȕ ͇ Ͱͥ

571 Where n is the number of ortholog groups K belonging to module m, CK is the number of hits to

572 ortholog group K, and MK is the total number of modules to which K belongs. To account for 573 differences in sequencingFor depthPeer between samples,Review module abundances Only were scaled to 500,000 574 reads per sample. To test the hypothesis that the NZ and SZ harbour significantly different

575 functional potential, oneway ANOSIM with 999 permutations was performed as above on a

576 standardised, logtransformed BrayCurtis distance resemblance matrix of the module and

577 ortholog group profiles. A functional profile was generated for each sample by summing the

578 scaled abundances of each module from all size fractions, and SIMPER performed as above to

579 identify modules which contributed highly to the variation in functional potential between the

580 two zones. Modules with a high contribution to variance or of specific interest were then linked

581 to (“taxonomic decomposition”) by noting the genus of the associated with

582 each gene in the KEGG GENES database and thus calculating the relative contribution of each

583 genus to each module’s abundance. This allowed us to putatively assign functional contributions

584 to genera which were not identified in our taxonomic analysis, as the database included gene

585 sequences for organisms for which a full genome was not available.

586

587 Acknowledgments

588

589 The authors acknowledge technical support for computing infrastructure and software

590 development from Intersect, and in particular assistance from Joachim Mai, and acknowledge

591 Matthew Lewis from the JCVI for his assistance with DNA sequencing. This work was

26 Wiley-Blackwell and Society for Applied Microbiology Page 27 of 848

592 supported by the Australian Research Council and the Australian Antarctic Division. Funding for

593 sequencing was provided by the Gordon and Betty Moore Foundation to the JCVI.

594

595 References 596 For Peer Review Only 597 Abell, G.C.J., and Bowman, J.P. (2005) Ecological and biogeographic relationships of class

598 Flavobacteria in the Southern Ocean. FEMS Microbiol Ecol 51 : 265277.

599 Alonso, C., and Pernthaler, J. (2006) Roseobacter and SAR11 dominate microbial glucose

600 uptake in coastal North Sea waters. Environ Microbiol 8: 20222030.

601 André, J.M., Navarette, C., Blanchot, J., and Radenac, M.H. (1999) Picophytoplankton

602 dynamics in the equatorial Pacific: Growth and grazing rates from cytometric counts. J

603 Geophys Res 104 : 33693380.

604 Angly, F.E., Willner, D., PrietoDavo, A., Edwards, R.A., Schmieder, R., VegaThurber, R. et al.

605 (2009) The GAAS metagenomic tool and its estimations of viral and microbial average

606 genome size in four major biomes. PLoS Comput Biol 5: e1000593.

607 Biastoch, A., Boning, C.W., Schwarzkopf, F.U., and Lutjeharms, J.R.E. (2009) Increase in

608 Agulhas leakage due to poleward shift of Southern Hemisphere westerlies. Nature 462 : 495

609 498.

610 Bidle, K.D., and Azam, F. (2001) Bacterial control of silicon regeneration from diatom detritus:

611 Significance of bacterial ectohydrolases and species identity. Limnol Oceanogr 46 : 1606

612 1623.

27 Wiley-Blackwell and Society for Applied Microbiology Page 28 of 848

613 Boning, C.W., Dispert, A., Visbeck, M., Rintoul, S.R., and Schwarzkopf, F.U. (2008) The

614 response of the Antarctic Circumpolar Current to recent climate change. Nature Geosci 1:

615 864869.

616 Bowman, J.P., and McCuaig, R.D. (2003) , Community Structural Shifts, and 617 BiogeographyFor of Prokaryotes Peer within ReviewAntarctic Continental ShelfOnly Sediment. Appl Environ 618 Microbiol 69 : 24632483.

619 Brinkhoff, T., Giebel, H.A., and Simon, M. (2008) Diversity, ecology, and genomics of the

620 Roseobacter clade: a short overview. Arch Microbiol 189 : 531539.

621 Brown, M., Lauro, F., DeMaere, M., Muir, L., Wilkins, D., Thomas, T. et al. (2012) Global

622 biogeography of SAR11 marine bacteria. Mol Syst Biol 8: 595.

623 Brown, M.V., and Bowman, J.P. (2001) A molecular phylogenetic survey of seaice microbial

624 communities (SIMCO). FEMS Microbiol Ecol 35 : 267275.

625 Buchan, A., and Moran, M.A. (2005) Overview of the Marine Roseobacter Lineage. Appl

626 Environ Microbiol 71: 56655677.

627 Campanaro, S., Williams, T.J., Burg, D.W., De Francisci, D., Treu, L., Lauro, F.M., and

628 Cavicchioli, R. (2011) Temperaturedependent global gene expression in the Antarctic

629 archaeon Methanococcoides burtonii . Environ Microbiol 13 : 20182038.

630 Carlson, C.A., Morris, R., Parsons, R., Treusch, A.H., Giovannoni, S.J., and Vergin, K. (2009)

631 Seasonal dynamics of SAR11 populations in the euphotic and mesopelagic zones of the

632 northwestern Sargasso Sea. ISME J 3: 283295.

633 Cavicchioli, R. (2006) Cold adapted Archaea. Nat Rev Microbiol 4: 331343.

28 Wiley-Blackwell and Society for Applied Microbiology Page 29 of 848

634 Chiba, S., Ishimaru, T., Hosie, G., and Fukuchi, M. (2001) Spatiotemporal variability of

635 zooplankton community structure off east Antarctica (90 to 160° E). Mar Ecol Prog Ser

636 216 : 95108.

637 Clarke, K.R., and Warwick, R.M. (2001) Change in Marine Communities: An Approach to 638 StatisticalFor Analysis and Peer Interpretation Review. Plymoth: PRIMERE. Only 639 Coleman, M.L., and Chisholm, S.W. (2010) Ecosystemspecific selection pressures revealed

640 through comparative population genomics. Proc Natl Acad Sci USA 107 : 1863418639.

641 Crump, B.C., Armbrust, E.V., and Baross, J.A. (1999) Phylogenetic analysis of particleattached

642 and freeliving bacterial communities in the Columbia river, its estuary, and the adjacent

643 coastal ocean. Appl Environ Microbiol 65 : 31923204.

644 Curson, A.R.J., Todd, J.D., Sullivan, M.J., and Johnston, A.W.B. (2011) Catabolism of

645 dimethylsulphoniopropionate: microorganisms, and genes. Nat Rev Microbiol 9:

646 849859.

647 Esper, O., and Zonneveld, K.A. (2002) Distribution of organicwalled dinoflagellate cysts in

648 surface sediments of the Southern Ocean (eastern Atlantic sector) between the Subtropical

649 Front and the Weddell Gyre. Mar Micropaleontol 46 : 177208.

650 Feller, G., and Gerday, C. (2003) Psychrophilic enzymes: hot topics in cold adaptation. Nat Rev

651 Microbiol 1: 200208.

652 Freitas, S., Hatosy, S., Fuhrman, J.A., Huse, S.M., Welch, D.B.M., Sogin, M.L., and Martiny,

653 A.C. (2012) Global distribution and diversity of marine Verrucomicrobia. ISME J 6: 1499

654 1505.

655 Fyfe, J.C., and Saenko, O.A. (2005) HumanInduced Change in the Antarctic Circumpolar

656 Current. J Climate 18 : 30683073.

29 Wiley-Blackwell and Society for Applied Microbiology Page 30 of 848

657 Ghiglione, J.F., and Murray, A.E. (2011) Pronounced summer to winter differences and higher

658 wintertime richness in coastal Antarctic marine bacterioplankton. Environ Microbiol 14 :

659 617629.

660 Giebel, H.A., Brinkhoff, T., Zwisler, W., Selje, N., and Simon, M. (2009) Distribution of 661 RoseobacterFor RCA and Peer SAR11 lineages Review and distinct bacterial Only communities from the 662 subtropics to the Southern Ocean. Environ Microbiol 11 : 21642178.

663 Giovannoni, S.J., Tripp, H.J., Givan, S., Podar, M., Vergin, K.L., Baptista, D. et al. (2005)

664 Genome streamlining in a cosmopolitan oceanic bacterium. Science 309 : 12421245.

665 Grote, J., Bayindirli, C., Bergauer, K., Carpintero de Moraes, P., Chen, H., D'Ambrosio, L.,

666 Edwards, B., et al. (2011). Draft genome sequence of strain HIMB100, a cultured

667 representative of the SAR116 clade of marine Alphaproteobacteria. SIGS 5: 269–278.

668 Grzymski, J.J., Riesenfeld, C.S., Williams, T.J., Dussaq, A.M., Ducklow, H., Erickson, M. et al.

669 (2012) A metagenomic assessment of winter and summer bacterioplankton from Antarctica

670 Peninsula coastal surface waters. ISME J 6: 1901–1915.

671 Hessen, D.O., Agren, G.I., Anderson, T.R., Elser, J.J., and de Ruiter, P.C. (2004) Carbon

672 Sequestration in Ecosystems: the Role of Stoichiometry. Ecology 85 : 11791192.

673 Howard, E.C., Sun, S., Biers, E.J., and Moran, M.A. (2008) Abundant and diverse bacteria

674 involved in DMSP degradation in marine surface waters. Environ Microbiol 10 : 23972410.

675 Hunt, B.P.V., Pakhomov, E.A., and McQuaid, C.D. (2001) Shortterm variation and longterm

676 changes in the oceanographic environment and zooplankton community in the vicinity of a

677 subAntarctic archipelago. Mar Biol 138 : 369381.

30 Wiley-Blackwell and Society for Applied Microbiology Page 31 of 848

678 Huston, A.L., KriegerBrocket, B.B., and Deming. J.W. (2000) Remarkably low temperature

679 optima for extracellular enzyme activity from Arctic bacteria and sea ice. Environ Microbiol

680 2: 383388.

681 Jung, S., Oh, T., and Yoon, J. (2006) Colwellia aestuarii sp. nov., isolated from a tidal flat 682 sediment inFor Korea. Int Peer J Syst Evol Microbiol Review 56 : 3337. Only 683 Junge, K., Eicken, H., and Deming, J.W. (2003) Motility of Colwellia psychrerythraea Strain

684 34H at Subzero Temperatures. Appl Environ Microbiol 69 : 42824284.

685 Kalanetra, K.M., Bano, N., and Hollibaugh, J.T. (2009) Ammoniaoxidizing Archaea in the

686 Arctic Ocean and Antarctic coastal waters. Environ Microbiol 11 : 24342445.

687 Kawahata, H., and Ishizuka, T. (2000) Amino acids in interstitial waters from ODP Sites 689 and

688 690 on the Maud Rise, Antarctic Ocean. Geochem J 34 : 247261.

689 King, G.M. (2003) Molecular and CultureBased Analyses of Aerobic Carbon Monoxide

690 Oxidizer Diversity. Appl Environ Microbiol 69 : 72577265.

691 Kirchman, D.L. (2002) The ecology of CytophagaFlavobacteria in aquatic environments. FEMS

692 Microbiol Ecol 39 : 91100.

693 Kjelleberg, S., Hermansson, M., Mårdén, P., and Jones, G. (1987) The transient phase between

694 growth and nongrowth of heterotrophic bacteria, with emphasis on the marine environment.

695 Annu Rev Microbiol 41 : 2549.

696 Kuwahara, H., Yoshida, T., Takaki, Y., Shimamura, S., Nishi, S., Harada, M. et al. (2007)

697 Reduced genome of the thioautotrophic intracellular symbiont in a deepsea clam,

698 Calyptogena okutanii . Curr Biol 17 : 881886.

699 Lauro, F.M., DeMaere, M.Z., Yau, S., Brown, M.V., Ng, C., Wilkins, D. et al. (2011) An

700 integrative study of a meromictic lake ecosystem in Antarctica. ISME J 5: 879895.

31 Wiley-Blackwell and Society for Applied Microbiology Page 32 of 848

701 Lauro, F.M., McDougald, D., Thomas, T., Williams, T.J., Egan, S., Rice, S. et al. (2009) The

702 genomic basis of trophic strategy in marine bacteria. Proc Natl Acad Sci U S A 106 : 15527

703 15533.

704 Liu, H., Nolla, H., and Campbell, L. (1997) Prochlorococcus growth rate and contribution to 705 primary productionFor in Peer the equatorial andReview subtropical North PacificOnly Ocean. Aquat Microb 706 Ecol 12 : 3947.

707 Liu, H., Campbell, L., Landry, M.R., Nolla, H.A., Brown, S.L., and Constantinou, J. (1998)

708 Prochlorococcus and Synechococcus growth rates and contributions to production in the

709 Arabian Sea during the 1995 Southwest and Northeast Monsoons. Deep-Sea Res Pt II 45 :

710 23272352.

711 Lomas, M.W., and Moran, S.B. (2011) Evidence for aggregation and export of cyanobacteria and

712 nanoeukaryotes from the Sargasso Sea euphotic zone. Biogeosciences 8: 203216.

713 Marchant, H.J., Davidson, A.T., and Wright, S.W. (1987) The Distribution and Abundance of

714 Chroococcoid Cyanobacteria in the Southern Ocean. Proc NIPR Symp Polar Biol 1: 19.

715 Mary, I., Heywood, J., Fuchs, B., Amann, R., Tarran, G., Burkill, P., and Zubkov, M. (2006)

716 SAR11 dominance among metabolically active low nucleic acid bacterioplankton in surface

717 waters along an Atlantic meridional transect. Aquat Microb Ecol 45 : 107113.

718 Methé, B.A., Nelson, K.E., Deming, J.W., Momen, B., Melamud, E., Zhang, X. et al. (2005) The

719 psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea

720 34H through genomic and proteomic analyses. Proc Natl Acad Sci U S A 102 : 1091310918.

721 Meyer, B., and Kuever, J. (2007) Molecular analysis of the diversity of sulfatereducing and

722 sulfuroxidizing prokaryotes in the environment, using aprA as functional marker gene. Appl

723 Environ Microbiol 73 : 76647679.

32 Wiley-Blackwell and Society for Applied Microbiology Page 33 of 848

724 Mikaloff Fletcher, S.E., Gruber, N., Jacobson, A.R., Doney, S.C., Dutkiewicz, S., Gerber, M. et

725 al. (2006) Inverse estimates of anthropogenic CO 2 uptake, transport, and storage by the

726 ocean. Global Biogeochem Cy 20 .

727 Moore, J.K., Abbott, M.R., and Richman, J.G. (1999) Location and dynamics of the Antarctic 728 Polar FrontFor from satellite Peer sea surface Reviewtemperature data. J Geophys Only Res 104 : 30593073. 729 Moran, M.A., Belas, R., Schell, M.A., González, J.M., Sun, F., Sun, S. et al. (2007) Ecological

730 genomics of marine Roseobacters. Appl Environ Microbiol 73 : 45594569.

731 Moran, M.A., Buchan, A., Gonzalez, J.M., Heidelberg, J.F., Whitman, W.B., Kiene, R.P. et al.

732 (2004) Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine

733 environment. Nature 432 : 910913.

734 Murray, A.E., and Grzymski, J.J. (2007) Diversity and genomics of Antarctic marine micro

735 organisms. Philos T Roy Soc B 362 : 22592271.

736 Myers, E. W., Sutton, G. G., Delcher, A. L., Dew, I. M., Fasulo, D. P., Flanigan, M. J., Kravitz,

737 S. A., et al . (2000). A wholegenome assembly of Drosophila . Science 287 :2196–2204.

738 Newton, I.L.G., Woyke, T., Auchtung, T.A., Dilly, G.F., Dutton, R.J., Fisher, M.C. et al. (2007)

739 The Calyptogena magnifica chemoautotrophic symbiont genome. Science 315 : 9981000.

740 Ng, C., DeMaere, M.Z., Williams, T.J., Lauro, F.M., Raftery, M., Gibson, J.a.E. et al. (2010)

741 Metaproteogenomic analysis of a dominant green sulfur bacterium from Ace Lake,

742 Antarctica. ISME J 4: 10021019.

743 Noguchi, H., Park, J., and Takagi, T. (2006) MetaGene: prokaryotic gene finding from

744 environmental genome shotgun sequences. Nucleic Acids Res 34 : 56235630.

33 Wiley-Blackwell and Society for Applied Microbiology Page 34 of 848

745 Obernosterer, I., Catala, P., Lebaron, P., and West, N.J. (2011) Distinct bacterial groups

746 contribute to carbon cycling during a naturally fertilized phytoplankton bloom in the

747 Southern Ocean. Limnol Oceanogr 56 : 23912401.

748 Oh, H.M., Kwon, K.K., Kang, I., Kang, S.G., Lee, J.H., Kim, S.J., and Cho, J.C. (2010) 749 Complete Forgenome sequence Peer of " Candidatus Review Puniceispirillum Only marinum" IMCC1322, a 750 representative of the SAR116 clade in the Alphaproteobacteria. J Bacteriol 192 : 32403241.

751 Orsi, H., Whitworth III, T., and Nowlin Jr, W.D. (1995) On the meridional extent and fronts of

752 the Antarctic Circumpolar Current. Deep-Sea Res Pt I 42 : 641673.

753 Partensky, F., Hess, W.R., and Vaulot, D. (1999) Prochlorococcus , a marine photosynthetic

754 prokaryote of global significance. Microbiol Mol Biol Rev 63 : 106127.

755 Pollard, R., Lucas, M., and Read, J. (2002) Physical controls on biogeochemical zonation in the

756 Southern Ocean. Deep-Sea Res Pt II 49 : 32893305.

757 Pop, M., Phillippy, A., Delcher, A.L., and Salzberg, S.L. (2004) Comparative genome assembly.

758 Brief Bioinform 5: 237248.

759 Preston, C.M., Wu, K.Y., Molinski, T.F., and DeLong, E.F. (1996) A psychrophilic

760 crenarchaeon inhabits a marine sponge: Cenarchaeum symbiosum gen. nov., sp. nov. Proc

761 Natl Acad Sci U S A 93 : 62416246.

762 Rappé, M.S., Connon, S.A., Vergin, K.L., and Giovannoni, S.J. (2002) Cultivation of the

763 ubiquitous SAR11 marine bacterioplankton clade. Nature 418 : 630633.

764 Rath, J., Wu, K.Y., Herndl, G.J., and DeLong, E.F. (1998) High phylogenetic diversity in a

765 marinesnowassociated bacterial assemblage. Aquat Microb Ecol 14 : 261269.

34 Wiley-Blackwell and Society for Applied Microbiology Page 35 of 848

766 Reisch, C.R., Stoudemayer, M.J., Varaljay, V.A., Amster, I.J., Moran, M.A., and Whitman, W.B.

767 (2011) Novel pathway for assimilation of dimethylsulphoniopropionate widespread in

768 marine bacteria. Nature 473 : 208211.

769 Rusch, D.B., Halpern, A.L., Sutton, G., Heidelberg, K.B., Williamson, S., Yooseph, S. et al. 770 (2007) TheFor Sorcerer IIPeer Global Ocean Review Sampling expedition: northwestOnly Atlantic through 771 eastern tropical Pacific. PLoS Biol 5: e77.

772 Sabine, C.L., Feely, R.A., Gruber, N., Key, R.M., Lee, K., Bullister, J.L. et al. (2004) The

773 oceanic sink for anthropogenic CO 2. Science 305 : 367371.

774 Selje, N., Simon, M., and Brinkhoff, T. (2004) A newly discovered Roseobacter cluster in

775 temperate and polar oceans. Nature 427 : 445448.

776 Sokolov, S., and Rintoul, S.R. (2002) Structure of Southern Ocean fronts at 140° E. J Marine

777 Syst 37 : 151184.

778 Sokolov, S., and Rintoul, S.R. (2009a) The circumpolar structure and distribution of the

779 Antarctic Circumpolar Current fronts. Part 2: Variability and relationship to sea surface

780 height. J Geophys Res-Oceans : C11.

781 Sokolov, S., and Rintoul, S.R. (2009b) The circumpolar structure and distribution of the

782 Antarctic Circumpolar Current fronts. Part 1: Mean circumpolar paths. J Geophys Res-

783 Oceans : C11.

784 Strutton, P., Brian Griffiths, F., Waters, R., Wright, S., and Bindoff, N. (2000) Primary

785 productivity off the coast of East Antarctica (80150° E): January to March 1996. Deep-Sea

786 Res Pt II 47 : 23272362.

35 Wiley-Blackwell and Society for Applied Microbiology Page 36 of 848

787 Swan, B.K., MartinezGarcia, M., Preston, C.M., Sczyrba, A., Woyke, T., Lamy, D. et al. (2011)

788 Potential for Chemolithoautotrophy Among Ubiquitous Bacteria Lineages in the Dark

789 Ocean. Science 333 : 12961300.

790 Swingley, W.D., Sadekar, S., Mastrian, S.D., Matthies, H.J., Hao, J., Ramos, H. et al. (2007) The 791 complete genomeFor sequence Peer of Roseobacter Review denitrificans reveals Only a mixotrophic rather than 792 photosynthetic metabolism. J Bacteriol 189 : 683690.

793 Thomalla, S.J., Waldron, H.N., Lucas, M.I., Read, J.F., Ansorge, I.J., and Pakhomov, E. (2011)

794 Phytoplankton distribution and nitrogen dynamics in the southwest indian subtropical gyre

795 and Southern Ocean waters. OS 7: 113127.

796 Topping, J.N., Heywood, J.L., Ward, P., and Zubkov, M.V. (2006) Bacterioplankton

797 composition in the Scotia Sea, Antarctica, during the austral summer of 2003. Aquat Microb

798 Ecol 45 : 229235.

799 Tripp, H.J., Kitner, J.B., Schwalbach, M.S., Dacey, J.W.H., Wilhelm, L.J., and Giovannoni, S.J.

800 (2008) SAR11 marine bacteria require exogenous reduced sulphur for growth. Nature 452 :

801 741744.

802 Trull, T., Rintoul, S.R., Hadfield, M., and Abraham, E.R. (2001) Circulation and seasonal

803 evolution of polar waters south of Australia: implications for iron fertilization of the

804 Southern Ocean. Deep-Sea Res Pt II 48 : 24392466.

805 VilaCosta, M., Simó, R., Harada, H., Gasol, J.M., Slezak, D., and Kiene, R.P. (2006)

806 Dimethylsulfoniopropionate uptake by marine phytoplankton. Science 314 : 652654.

807 WagnerDobler, I., and Biebl, H. (2006) Environmental biology of the marine Roseobacter

808 lineage. Annu Rev Microbiol 60 : 255280.

36 Wiley-Blackwell and Society for Applied Microbiology Page 37 of 848

809 Walker, C.B., de la Torre, J.R., Klotz, M.G., Urakawa, H., Pinel, N., Arp, D.J. et al. (2010)

810 Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and

811 autotrophy in globally distributed marine crenarchaea. Proc Natl Acad Sci U S A 107 : 8818

812 8823. 813 Walsh, D.A., Zaikova,For E., PeerHowes, C.G., Song,Review Y.C., Wright, J.J., Only Tringe, S.G. et al. (2009) 814 Metagenome of a versatile chemolithoautotroph from expanding oceanic dead zones.

815 Science 326 : 578582.

816 Ward, P., Whitehouse, M., Brandon, M., Shreeve, R., and WooddWalker, R. (2003)

817 Mesozooplankton community structure across the Antarctic Circumpolar Current to the

818 north of South Georgia: Southern Ocean. Mar Biol 143 : 121130.

819 Weber, T.S., and Deutsch, C. (2010) Ocean nutrient ratios governed by plankton biogeography.

820 Nature 467 : 550554.

821 West, N.J., Obernosterer, I., Zemb, O., and Lebaron, P. (2008) Major differences of bacterial

822 diversity and activity inside and outside of a natural ironfertilized phytoplankton bloom in

823 the Southern Ocean. Environ Microbiol 10 : 738756.

824 Whitworth III, T. (1980) Zonation and geostrophic flow of the Antarctic circumpolar current at

825 Drake Passage. Deep-Sea Res 27 : 497507.

826 Wilkins, D., Yau, S., Williams, T.J., Allen, M.A., Brown, M.V., DeMaere, M.Z., et al. (2012)

827 Key microbial drivers in Antarctic aquatic environments. FEMS Microbiol Rev doi:

828 10.1111/15746976.12007

829 Williams, G.D., Nicol, S., Aoki, S., Meijers, A.J.S., Bindoff, N.L., Iijima, Y. et al. (2010)

830 Surface oceanography of BROKEWest, along the Antarctic margin of the southwest Indian

831 Ocean (3080° E). Deep-Sea Res Pt II 57 : 738757.

37 Wiley-Blackwell and Society for Applied Microbiology Page 38 of 848

832 Williams, T.J., Lauro, F.M., Ertan, H., Burg, D.W., Poljak, A., Raftery, M.J., and Cavicchioli, R.

833 (2011) Defining the response of a microorganism to temperatures that span its complete

834 growth temperature range (2°C to 28 °C) using multiplex quantitative proteomics. Environ

835 Microbiol 13 : 21862203. 836 Williams, T.J.,For Long, E., Evans,Peer F., Demaere, Review M.Z., Lauro, F.M., Only Raftery, M.J. et al. (2012a) A 837 metaproteomic assessment of winter and summer bacterioplankton from Antarctic Peninsula

838 coastal surface waters. ISME J 6: 18831900.

839 Williams, T.J., Wilkins, D., Long, E., Evans, F., DeMaere, M.Z., and Raftery, M.J. (2012b) The

840 role of planktonic Flavobacteria in processing algal organic matter in coastal East Antarctica

841 revealed using metagenomics and metaproteomics. Environ Microbiol doi:10.1111/1462

842 2920.12017

843 Yau, S., Lauro, F.M., DeMaere, M.Z., Brown, M.V., Thomas, T., Raftery, M.J. et al. (2011)

844 Virophage control of antarctic algal hostvirus dynamics. Proc Natl Acad Sci USA 108 :

845 61636168.

846 Ye, Y., and Doak, T.G. (2009) A parsimony approach to biological pathway

847 reconstruction/inference for genomes and metagenomes. PLoS Comput Biol 5: e1000465.

848 Yoon, J., YasumotoHirose, M., Katsuta, A., Sekiguchi, H., Matsuda, S., Kasai, H., and Yokota,

849 A. (2007) Coraliomargarita akajimensis gen. nov., sp. nov., a novel member of the phylum

850 'Verrucomicrobia' isolated from seawater in Japan. Int J Syst Evol Microbiol 57 : 959963.

851 Zhang, R., Liu, B., Lau, S.C.K., Ki, J.S., and Qian, P.Y. (2007) Particleattached and free

852 living bacterial communities in a contrasting marine environment: Victoria Harbor, Hong

853 Kong. FEMS Microbiol Ecol 61 : 496508.

854

38 Wiley-Blackwell and Society for Applied Microbiology Page 39 of 848

855 Supporting information

856

857 Additional Supporting Information may be found in the online version of this article:

858 859 Fig. S1. NeighbourjoiningFor Peer tree of GSOEOSA1like Review 16S rRNA Only gene sequences from the SO. 860 Sequence labeled in black text are reads from our metagenomic dataset; in red text are 16S rRNA

861 gene sequences from Gammaproteobacterial Sulphur Oxidisers (GSO) and other

862 gammoproteobacteria from Genbank. The tree was constructed using ARB (Ludwig et al.,2004).

863

864 Table S1. Full sample information including physiochemical parameters.

865

866 Table S2. Relative abundances of all OTUs in all samples from all size fractions. Size fraction is

867 given in OTU name, e.g. the column “Mycoplasma genitalium strain G3708” represents the

868 relative abundance of the Mycoplasma genitalium G37 OTU in the 0.8 m size fraction.

869

870 Table S3. Contributions of individual OTUs to variance between the North and South zones.

871 Size fraction is given in OTU name, e.g. the row “Mycoplasma genitalium strain G3708”

872 represents the contribution to variance of the Mycoplasma genitalium G37 OTU in the 0.8 m

873 size fraction.

874

875 Table S4. Genes related to aerobic respiration annotated in scaffolds from assemblies of GSO

876 EOSA1 affiliated reads. Assembly of reads with identity to Ca. “Ruthia magnifica” or Ca.

877 “Vesicomyosocius okutanii” was performed with WGS ASSEMBLER (Celera, Alameda) and ORFs

39 Wiley-Blackwell and Society for Applied Microbiology Page 40 of 848

878 predicted with META GENE (Noguchi et al. 2006). ORFs were annotated with BLASTN against the

879 NCBI nr database (Evalue threshold 1.0 × 10 3). Only selected matches relevant to aerobic

880 respiration are shown.

881 882 Table S5. ContributionsFor ofPeer KEGG ortholog Review groups to variance bOnlyetween the North and South 883 zones. Size fraction is given in ortholog group name, e.g. the row “DNA polymerase III subunit

884 alpha [EC:2.7.7.7]08” represents the contribution to variance of the DNA polymerase III

885 subunit alpha ortholog group in the 0.8 m size fraction.

886

887 Table S6. Contributions of KEGG modules to variance between the North and South zones.

888

889 Figure legends

890

891 Fig. 1. Sites of samples used in this study. The area depicted is in the Australian sector of the

892 Southern Ocean. Samples are from the North zone (triangles) and South zone (squares). The

893 dashed line gives the approximate position of the Polar Front, associated with a major core of the

894 Antarctic Circumpolar Current (ACC), at the time of the voyage.

895

896 Fig. 2. Contribution of OTUs to variance between North and South zones, and differential

897 abundance of OTUs from each size fraction between the two zones. Each coloured (red or blue)

898 rectangle represents an OTU identified through analysis of BLAST matches between SO

899 metagenome data and the RefSeq database. The area of each rectangle as a proportion of the total

900 plot area corresponds to that OTU’s contribution to the total variance between the two zones.

40 Wiley-Blackwell and Society for Applied Microbiology Page 41 of 848

901 The colour of each rectangle corresponds to difference in relative abundance of that OTU

902 between the zones, with blue indicating a higher relative abundance south of the PF, and red a

903 higher abundance north of the PF. OTUs from clades or taxonomic ranks of interest have been

904 grouped, with labels in bold and groups separated by gray lines. Groups and OTUs with a low 905 contribution toFor variance whichPeer were not groupedReview are unlabeled. OTUsOnly from each size fraction 906 have also been grouped, with labels in black outline and size fractions separated by thick black

907 lines. The total contribution to variance of each size fraction is given as a percentage. Full data

908 are given in Table S3, supporting information.

909

910 Fig. 3. Decomposition of KEGG modules of interest to contributing classes, orders or genera.

911 The left side of each stack (S) indicates the proportion of the module abundance contributed by

912 each class, order or genus in the South Zone, while the right side (N) represents the North Zone.

913 As the contributions are relative and represent unitless module abundances, no axis is given and

914 proportions are not comparable between modules. Contributing classes, orders or genera are

915 arranged in descending order of the difference in the relative contributions between the zones.

916 Only the eight highest contributors for each module are shown, with the remainder collapsed into

917 the “Other” group. The taxonomic ranks to which each module was decomposed are as follows:

918 snglycerol 3phosphate transport, peptidenickel transport, simple sugar transport and

919 sulfonate/nitrate/taurine transport were decomposed to order; glycine betaine/proline transport

920 and branchedchain amino acid transport to genus; pyrimidine deoxyribonucleotide biosynthesis,

921 adenine nucleotide biosynthesis and guanine nucleotide biosynthesis to order; methionine

922 salvage to genus; sulphur reduction to class; photosystem I and photosystem II to genus;

923 histidine degradation to glutamate and histidine biosynthesis to class.

924

41 Wiley-Blackwell and Society for Applied Microbiology Page 42 of 848

925 Table 1. Average OTU abundances for each size fraction and zone

OTU North Zone South Zone 0.1 m 0.8 m 3.0 m 0.1 m 0.8 m 3.0 m Ca. “Pelagibacter ubique” HTCC1062 61.8 25.0 23.9 58.9 22.4 17.6

Synechococcus sp. CC9902 0.11 9.84 4.97 0.00 0.00 0.10 Roseobacter sp.For OCh114 Peer 0.31Review 2.93 1.59 Only 0.45 3.99 2.66 Synechococcus sp. CC9311 0.03 4.62 4.41 0.00 0.00 0.03

Ca. “Ruthia magnifica” str. Cm 0.67 0.65 0.55 2.99 2.62 1.03 (Calyptogena magnifica )

Silicibacter pomeroyi DSS3 0.26 2.29 1.15 0.31 2.51 1.58

Gramella forsetii strain KT0803 0.24 1.21 1.75 0.50 2.35 1.89

Ca. “Puniceispirillum marinum” 0.64 2.08 1.27 0.36 1.38 0.71 IMCC1322

Robiginitalea biformata strain 0.28 1.10 1.30 0.47 1.88 1.40 HTCC2501

Flavobacterium psychrophilum strain 0.17 0.84 1.22 0.43 1.96 1.60 JIP02/86

Silicibacter sp. TM1040 0.23 1.65 0.87 0.27 1.80 1.23

Ca. “Vesicomyosocius okutanii” strain 0.46 0.46 0.21 1.97 1.81 0.22 HA

Jannaschia sp. DFL12 0.18 1.38 0.74 0.24 1.69 0.80

Zunongwangia profunda strain SMA87 0.15 0.75 1.06 0.30 1.41 1.20

Colwellia sp. 34H 0.02 0.36 2.74 0.05 0.51 1.04

Pseudoalteromonas atlantica strain T6c 0.01 0.48 1.99 0.02 0.41 1.13

Jannaschina sp. CCS1 0.12 0.93 0.48 0.17 1.23 0.82

42 Wiley-Blackwell and Society for Applied Microbiology Page 43 of 848

Nitrosopumilus maritimus SCM1 0.02 0.01 0.01 1.08 1.31 1.21

Coraliomargarita akajimensis strain 0.04 0.08 0.12 0.12 1.54 1.68 DSM 45221

Flavobacterium johnsoniae strain 0.09 0.42 0.61 0.20 0.94 0.86 UW101

926 For Peer Review Only

927 * OTU identifications and abundances based on GAAS and MINSPEC analysis of BLAST

928 matches between the SO metagenomic dataset and RefSeq. This table includes the twenty overall

929 most abundant OTUs. A complete of all OTU abundances for all samples and size fractions is

930 available in the supporting information (Table S2). Abundances are relative and expressed as

931 percentages.

932

43 Wiley-Blackwell and Society for Applied Microbiology Page 44 of 848

933 Table 2. KEGG modules which contribute highly to variance between the NZ and SZ. A

934 complete list of modules which contribute to variance is given in the supporting information

935 (Table S5).

KEGG module Average abundance Contribution

(standardised and log to variance

For Peer Reviewtransformed) Only (%)

North Zone South Zone

Photosystem II 0.57 0.42 2.21

Complex I (NADH dehydrogenase), NADH 0.24 0.01 1.80

dehydrogenase I/diaphorase subunit of the

bidirectional hydrogenase

Photosystem I 0.34 0.43 1.70

Pyrimidine deoxyribonuleotide biosynthesis, 0.66 0.51 1.16

CDP/CTP => dCDP/dCTP,dTDP/dTTP

Histidine degradation, histidine => N 0.31 0.42 1.14

formiminoglutamate => glutamate

Methionine salvage pathway 0.43 0.29 1.14

snGlycerol 3phosphate transport system 0.16 0.29 1.11

Complex I (NADH dehydrogenase), NADH 1.05 1.08 1.06

dehydrogenase I

Branchedchain amino acid transport system 0.83 0.79 0.96

Dipeptide transport system 0.02 0.14 0.95

Adenine nucleotide biosynthesis, IMP => 0.74 0.62 0.95

ADP/dADP,ATP/dATP

Glycine betaine/proline transport system 0.56 0.66 0.94

44 Wiley-Blackwell and Society for Applied Microbiology Page 45 of 848

Sulfur reduction, sulfate => H2S 0.44 0.54 0.91

Simple sugar transport system 0.39 0.46 0.9

Peptides/nickel transport system 0.98 0.99 0.89

936 937 The following Forfigures are presentedPeer in the Review order Figure 1-3. Only

45 Wiley-Blackwell and Society for Applied Microbiology Page 46 of 848

For Peer Review Only

Wiley-Blackwell and Society for Applied Microbiology Page 47 of 848

For Peer Review Only

Wiley-Blackwell and Society for Applied Microbiology Page 48 of 848

For Peer Review Only

Wiley-Blackwell and Society for Applied Microbiology Page 49 of 848

1 Supporting Information

2

3 Fig. S1. Neighbour-joining tree of GSO-EOSA-1-like 16S rRNA gene sequences from the SO.

4 Sequence labeled in black text are reads from our metagenomic dataset; in red text are 16S rRNA 5 gene sequencesFor from Gammaproteobacterial Peer Review Sulphur Oxidisers (GSO)Only and other 6 gammoproteobacteria from Genbank. The tree was constructed using ARB (Ludwig et al., 2004).

7

8 Table S1. Full sample information including physiochemical parameters.

9

10 Table S2. Relative abundances of all OTUs in all samples from all size fractions. Size fraction is

11 given in OTU name, e.g. the column “Mycoplasma genitalium strain G37-08” represents the

12 relative abundance of the Mycoplasma genitalium G37 OTU in the 0.8 μm size fraction.

13

14 Table S3. Contributions of individual OTUs to variance between the North and South zones. Size

15 fraction is given in OTU name, e.g. the row “Mycoplasma genitalium strain G37-08” represents

16 the contribution to variance of the Mycoplasma genitalium G37 OTU in the 0.8 μm size fraction.

17

18 Table S4. Genes related to aerobic respiration annotated in scaffolds from assemblies of GSO-

19 EOSA-1 affiliated reads. Assembly of reads with identity to Ca. “Ruthia magnifica” or Ca.

20 “Vesicomyosocius okutanii” was performed with WGS-ASSEMBLER (Celera, Alameda) and ORFs

21 predicted with METAGENE (Noguchi et al. 2006). ORFs were annotated with BLASTN against the

22 NCBI nr database (E-value threshold 1.0 × 10-3). Only selected matches relevant to aerobic

23 respiration are shown.

24

1 Wiley-Blackwell and Society for Applied Microbiology Page 50 of 848

25 Table S5. Contributions of KEGG ortholog groups to variance between the North and South

26 zones. Size fraction is given in ortholog group name, e.g. the row “DNA polymerase III subunit

27 alpha [EC:2.7.7.7]-08” represents the contribution to variance of the DNA polymerase III subunit

28 alpha ortholog group in the 0.8 μm size fraction. 29 For Peer Review Only 30 Table S6. Contributions of KEGG modules to variance between the North and South zones.

31

32 The following supplementary figure is Fig. S1. Tables S1-S6 are provided separately as excel

33 files.

2 Wiley-Blackwell and Society for Applied Microbiology Page 51 of 848

For Peer Review Only

Wiley-Blackwell and Society for Applied Microbiology Page 52 of 848

Table S1. Full sample information including physiochemical parameters. Sample Zone Latitude Longitude Location Fluorescence (ug/l) Temp (ITS-90) 346 North -59.18 142.27 S.O. transect 0.25 2.924 347 South -66.0213 142.738 Commonwealth Bay 4 0.6 349 South -66.5575 142.3173 Adélie bank 3.745 -1.2769 351 South -66.6642 143.0237 George V Basin 1.642 -0.6541 352 South -66.757 143.2887 Commonwealth Bay 1.037 -0.8353 353 South -67.0432 144.6667 Buchannan Bay 0.3 -1.8154 357 South -66.1692 142.9258 Mertz Bank 2.671 -0.4526 358 South -64.302 149.9997 Continental Slope 0.267 -0.0349 359 South -65.9172 143.9967 Mertz Bank 2.4 0.047 360 SouthFor-66.5638 Peer140.8653 ReviewPoint Martin Only7.503 -0.6601 362 South -65.5367 140.8287 Continental Slope 0.5 0.7 363 North -59.595 141.13506 S.O. transect 0.1 3.547 364 North -56.4136 141.52062 S.O. transect 0.5 4.16 366 North -52.012 144.0347 S.O. transect 0.25 7.656 367 North -48.1396 145.4765 S.O. transect 0.2 10.94 368 North -44.4254 145.4515 S.O. transect 1.25 14.24

Wiley-Blackwell and Society for Applied Microbiology Page 53 of 848

Salinity (PSS78) Oxygen (umol/kg) Local Date Local Time Water Column Depth (m) 33.762 -- 12/20/2007 16:32 4294 34.2 -- 12/23/2007 11:42 450 34.4381 347.69 12/27/2007 17:51 370 34.3874 357.49 12/28/2007 13:31 823 34.3431 356.8 12/29/2007 11:16 164 34.4626 315.43 12/30/2007 12:05 180 34.2101 351.28 1/5/2008 0:48 580 33.588 343.46 1/9/2008 17:10 3550 34.1126 351.92 1/12/2008 1:11 540 34.1173For Peer363.52 1/13/2008 Review22:39 Only316 32.2 -- 1/19/2008 19:32 1064 33.754 -- 1/22/2008 14:05 4473 33.713 -- 1/23/2008 8:45 3693 33.837 -- 1/24/2008 14:54 3180 34.43 -- 1/25/2008 10:35 3490 34.715 -- 1/26/2008 9:37 3201

Wiley-Blackwell and Society for Applied Microbiology Page 54 of 848

Sample Depth (m) Weather Volume seawater filtered (l) 2 overcast 500 2 overcast 250 1.5 cold and clear 250 1.5 clear sunny 500 2.5 clear and sunny 500 2 clear and sunny 500 2 overcast 500 2 clear wind 500 2 clear sunset/sunrise500 For2 cold Peer500 Review Only 2 overcast, windy 500 2 overcast wind 500 2 clear, windy 500 2 clear, windy 500 2 overcast, windy 500 2 sunny 560

Wiley-Blackwell and Society for Applied Microbiology Page 55 of 848

Table S2. Relative abundances of all OTUs in all samples from all size fractions. Sample MycoplasmaActinobacillus genitaliumPolaromonas strain pleuropneumoniae G37-08Bacillus naphthalenivorans cereus Pelotomaculumstrain strain L20-01 AH820-01strainHirschia thermopropionicumCJ2-01 balticaAzospirillum strain ATCCThermomonospora sp. strain B510-0849814-01 SI-30 curvata strain DSM 43183-01 365 0 0 0.008688 0.000521 0 0.018259 0.149337 0.023021 347 0 0 0.001103 0 0 0.002876 0.003641 0.000609 346 0 0.000603 0.000817 2.03E-05 0 0.006476 0.022301 9.91E-05 358 0 0 0.004414 0 0 0.017585 0.004873 5.53E-05 363 0 0 0.002377 0.000134 0 0.014136 0.006245 0.000731 360 0 0 0.005582 1.33E-05 0 0.006786 0.010654 0.000328 353 0 0.002223 0.002305 0.000109 1.45E-05 0.015411 0.106331 0.002256 349 0 0 0.001198 0 0 0.008898 0.012773 0.001687 366 For0 Peer0 0.00177 7.23E-05Review0 0.008725 Only0.015284 0.000978 352 0 0 0.002127 4.11E-05 0 0.012058 0.01664 5.42E-05 351 1.64E-05 0.001973 0.001255 0.000134 0 0.01487 0.005703 0.001258 364 0 0 0.002249 0 0 0.014611 0.013161 0.001951 359 0 0 0.004722 0.000142 0 0.013278 0.017087 0.000593 368 0 0.001682 0.001515 0.000101 0 0.016473 0.005084 0.002394 361 0 0 0.005041 0 0.013609 0.013859 0.137938 0.00226 367 0 0 0.001399 0.000138 0.022208 0.010792 0.013887 0.001242 356 0 0 0.006272 6.82E-05 0.010196 0.011016 0.148989 0.002417 362 0 0.000718 0.001148 2.24E-05 0 0.004598 0.000797 0.000431 357 0 0 0.004258 0 0 0.014882 0.005494 4.30E-05

Wiley-Blackwell and Society for Applied Microbiology Page 56 of 848

Listeria monocytogenesArchaeoglobusNeisseria strain fulgidus 4b meningitidis F2365-30Anaplasma strain VC-16-01 Corynebacteriumserogroupmarginale BstrainRhodopseudomonas strain St. nigricans MC58-30 Maries-30Francisella CN-1-08 palustris tularensisBrucella strain melitensis subsp.Streptococcus BisB5-01 tularensis str. ATCC gallolyticus strain 23456-01 SCHU strain S4-30 UCN34-01 0 0.00283 0 0 0.002522 0.008194 0 0 0.000387 0 0 0 0 0.000248 0.000786 0 0 0 0 0 0 0 0 0.002381 0 1.80E-06 0 0 0 0 0 0.006585 0.001761 0.070402 0 0 0 0 0 0 0 0.005001 0 0 0 0 0 0.150594 0.322528 0.006877 0.002179 0 0 0 0 3.25E-12 2.08E-08 0.147566 0.000936 0.00276 0.053188 0 0.000149 2.65E-09 2.93E-05 0.148063 0 0.008406 0.002172 0 0 9.02E-07 0 For0 0.013388 Peer0 0.001802Review0.003431 Only0 0 0 0 8.61E-05 0.066852 0 0.000894 0.000942 0 0 0 8.23E-10 9.82E-12 0.023237 0.054479 0.003524 0.003995 0 0 0 0 0 0.036021 0 0 0.003857 0 0 0 9.95E-12 0 0.046855 0 0.002151 0.002061 0 0 2.81E-07 0 7.83E-05 0.024433 0.002765 0 0.0052 0 0 0 0 8.80E-05 3.52E-05 0 0.001558 0.00746 0.127993 0 0 0 0 0.002124 0 0.003102 0.004147 0 0 0 0 0.001082 0.005726 0 0 0.003309 0 0 0 0 0 0 0.141293 0.000899 0.001625 0 0.00044 6.31E-05 0 0 0.000755 0 0.000267 0.002658 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 57 of 848

RenibacteriumBorrelia salmoninarum burgdorferiMethylobacterium strain strainCandidatus ATCC ZS7-30 sp.33209-30 RhizobiumCM4-30Sulcia muelleri leguminosarumAcidimicrobium strain DMIN-01Thermoplasma bv.ferrooxidans viciaeAcinetobacter str. volcanium strain3841-08Chlamydophila DSM baumanniistrain 10331-30 GSS1-01 strain pneumoniae AB307-0294-30 TW183-08 0 0 0.000958 1.21E-09 0.014008 0 0.039619 0.005131 0 0 0 0.005216 0.000487 0.011231 0 0 0 0 0 0 0.000497 0.002802 0.005918 0 0 0.01912 0 0 0 0.016392 0 0.015117 0 0 0 0 0 0 0.001783 0.017108 0.010657 0 0 0.032326 0 0 0 0.010234 0.015247 0.012117 0 0 0.026772 0 0 0 0.005582 0.009349 0.009816 0.18277 2.69E-12 0 0 0 0 0 0 0.008859 0 0 0 0 0 For0 0.002212 Peer0.00035 0.005245Review0.013689 Only0 0 0 0 0 0.003126 0.00346 0.014548 0 0 0 0 0 0 0.002275 0.031699 0.00932 0.000542 0.000112 0 0 0 0 7.26E-06 0.014206 0.012222 0 0 0 0 0 0 0.003593 0 0.016427 0 0 0 0 0 0 0.001819 0.012384 0.002367 0.025714 0 0 0 3.75E-18 0 0.002255 0.006638 0.013335 0.109625 7.05E-12 0.016297 0 4.26E-05 0 0.003853 0.000655 0.003284 0.03358 0 0 0 0.006524 0.000102 0.008471 0.013168 0.006956 0.143067 0.000244 0.006494 0.0094 0 0 0.000223 0.001777 0.006516 0 1.12E-09 0.035543 0 5.60E-08 0 0.00026 0.014172 0.015265 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 58 of 848

DesulfotaleaMethanosphaerula psychrophilaLeifsonia LSv54-08 palustris xyliHistophilus subsp. strain xyli Yersiniasomni E1-9c-08 strain str. CTCB07-08pestis 2336-08Hyphomonas strain Angola-08Synechococcus neptuniumChlamydophila strain sp. PCC ATCCHeliobacterium 7425-01 15444-30 pneumoniae modesticaldum TW183-01 strain Ice1-01 0.055776 0.026719 0.00111 0.039606 0 0.209742 0.00035 0.000346 0.009157 0.055603 0 9.89E-13 0.074486 0 0 0.004177 0 6.41E-05 0.02224 0 7.50E-15 0.00485 0 0.12642 0.001572 0 0 0.026555 0 0 0.00695 0 0.058195 9.56E-11 0 0 0.023973 0.000132 3.21E-05 0.007054 0 0.051889 8.03E-05 0 9.38E-05 0.029609 0 2.16E-14 0.033632 0 0 0.004809 0 7.38E-05 0.055733 0 0.000166 0.00344 0 0.124408 0.00013 1.04E-12 0.001296 0.032806 0 6.53E-05 0 0 0.128575 0.002127 0 0 0.008583 0.000664For0.004106 Peer0 Review0 0.0372 4.45E-05 Only 0 0.002045 0.033736 0 0.001129 0.028718 0 1.17E-13 0.003104 0 0.000971 0.035014 0 0 0.02899 0.005516 0.020537 0.000556 0 0.000231 0.010211 0.000241 3.27E-08 0.024241 0 0.243036 0.000405 0 0.001008 0.041204 0 0.003591 0 0 0.001576 1.37E-05 0 0 0.000196 5.24E-06 0 0 0 0.00133 0.002012 0 0.000262 0.060158 0.004468 0.009946 0 0 0.069518 0.002329 0 0.00142 0.004015 0.003778 2.35E-05 0.005942 0 0.065193 1.14E-05 0 0.000861 0.034763 0.006214 0.004871 0.01526 0 0.031486 0.001905 0.000419 0.003241 0.020542 0 3.24E-05 0 0 0.135814 3.10E-05 0 0.000143 0.044753 0 0.000363 0.042975 0 0.046395 0.000476 0 0.000154

Wiley-Blackwell and Society for Applied Microbiology Page 59 of 848

Francisella tularensisShewanella subsp.Porphyromonas sp. PV-4-01 holarcticaExiguobacterium straingingivalis ClostridiumOSU18-01 strain strain W83-08Lactobacillus cellulolyticum255-15-01Clostridium salivarius strain H10-30Streptococcus subsp.perfringens salivariusBurkholderia strain equi UCC118-01 SM101-01subsp. mallei zooepidemicus str. ATCC 23344-01 strain MGCS10565-08 0 0.003811 0.012847 0.002049 0 0 0.001215 0 0 0 0.001633 0.035829 0.000829 0 0 0 0 7.60E-05 0.005818 0.006078 0.042409 1.72E-05 0.000351 0 0 0.004016 0.000343 0 0.007389 0.039609 0.002144 0 0 6.33E-08 0 5.41E-06 0 0.002528 0 3.87E-20 0.008853 0.00137 5.26E-05 0 0 0 0.008558 0 0.000202 0 0 0.000449 0 0 0 0.01037 0.032451 0.000823 0.012307 0 0.000598 0 0.000172 0 0.007142 0 4.02E-16 0 0 9.39E-05 0 0 0 0.002891For Peer0 0 Review0 0 Only0 0 0 0 0.005494 0.023427 0.001524 0 0 0.000102 0 3.72E-05 0 0.010362 0.017822 0.000747 0 1.57E-05 3.31E-05 0 0.000144 0.007584 0.006649 0 2.68E-07 0 0 0.000167 0 0 0 0.016513 0 6.23E-05 0.046168 0 0.000547 0 0 0.001666 0.000922 0.002487 0.001362 0 0 1.40E-05 0 0 0 0.008582 0 0.000142 0.014326 3.19E-10 0.001005 3.20E-09 0.000318 0.004455 0.001837 0.011976 0.000133 0 2.12E-08 4.66E-05 0 0 0 0.010246 0.037943 0.001806 0.0061 0.000206 0.000151 0 8.98E-05 0.004032 0.002264 0.011596 0 0.000153 0 0 0 0 0 0.021314 0.03063 0.000795 0.020495 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 60 of 848

GluconacetobacterMycobacterium diazotrophicusMoorella tuberculosis thermoaceticaNostoc strain strain PAlsp. PCC73102-085-01Pseudoalteromonas H37Ra-08 strain ATCCRalstonia 39073-01 haloplanktis solanacearumStreptococcus strainCaulobacter strain pneumoniae TAC125-30 GMI1000-08Brucella crescentus strain abortus 70585-08 strain strain NA1000-01 S19-30 0.005896 0 0.025905 0.007714 0 0.004764 0.01499 0.033925 0 0.000195 0 0.000115 0.007186 0.003137 0.004479 0 0.000736 0 0.000154 0 6.25E-06 0.004417 0.063712 0.001287 0 0 0 0.001169 0 0 0.003156 1.240168 0.003813 0 0.003531 0 0.001188 0 9.70E-05 0.000331 0.471216 0.000674 0 0.009135 0 0.000539 0 0.000434 0.001398 1.509742 0.005371 0 0.006052 0 0.003136 0 2.13E-05 0.004151 0 0.003994 0 0 0 0.001291 0 0.000175 0.003789 0 0.003943 0 0.004758 0 0.001336 For0 0.000181 Peer0.000648 0.606039Review0.000657 Only0 0 0.007254 0.000579 0 5.40E-05 0.001909 0.155628 0.008209 0 0 0 0.001025 2.07E-05 1.79E-07 0.001891 0.273664 0.005118 0 0 0 0.001597 0 0.000768 0.008303 2.556168 0.00168 0 0 0 0.000878 0 0 0.002812 0.617717 0.010753 0 0.003464 0 0.001482 7.55E-05 0.002761 0.007488 0.704286 0.00102 0 0 0 0.001199 0 0.000975 0.002201 0.255185 0.001631 0 0.003003 0 0.000881 0 0 0.0056 0.936192 0.001137 0 0.005577 0 0.000811 0.018103 0.003483 0.00474 0.195791 0.001783 0 0 0 0.000773 0 0 0.00187 2.53276 0.00522 0 0 0 0.000236 0 0 0.001689 0.197231 0.005619 0 0.005212 0

Wiley-Blackwell and Society for Applied Microbiology Page 61 of 848

Dickeya zeaeStaphylococcus strain Ech1591-30Vibrio epidermis vulnificusChlorobium RP62A-01 str. YJ016-01Frankia phaeobacteroides sp. ThermosynechococcusCcI3-01 strainCandidatus BS1-30 DesulfotaleaBlochmanniaelongatus strainJannaschina psychrophila pennsylvanicus BP-1-30 sp. LSv54-01 CCS1-08 strain BPEN-08 0 0 0.005738 6.95E-05 0.006501 0 0 0.032088 0.152395 0.002659 0 0.001867 0.299179 0 0.909888 0.0105 0.003913 1.007465 0.000545 0 0.002253 0.052154 0.000575 0.165363 0 0.003389 1.890623 0.01822 0 0.00198 0 0 0.029215 0 0.002375 2.136062 0.007885 0 0.004176 0.037973 4.14E-05 0.084143 0 0.001922 1.265614 0.029513 2.47E-06 0.005515 0.274088 7.32E-06 0.19483 0 0.007332 1.257468 0 0.000108 0.00488 0.002387 0.000587 0.198707 0 0.006037 0.585281 0 3.54E-05 0.009832 0.182118 0.000238 0 0 0.019617 0.971978 0.003941 For0 0.002312 Peer0 1.90E-06Review0.032092 Only0 0.002752 0.614047 0.005474 0.001373 0.004572 0.191806 1.28E-05 0.898831 0 0.00245 0.772633 0 1.66E-05 0.004148 0.16098 0.000574 0.346136 0.003643 0.005971 0.777917 0.003082 1.80E-05 0.000222 0 0.000188 0.222515 0 0.003232 1.139597 0.04238 0 0.010989 0.250984 3.48E-05 0.478142 0 0.012461 1.563929 0.000726 0 0.00193 0 0.001781 0 0 0.002478 0.251295 0.006278 0.000334 0.003452 0.105629 1.64E-06 0.037702 0 0.005857 0.711015 0.00749 0.000358 0.00138 0.08537 0.000662 0.098495 0 0.00086 0.445332 0.001612 0.000189 0.00365 0.026333 0.001429 0.057461 0 0.012561 0.475123 0.02314 0 0.000733 0.067021 0 0.294701 0 0.00412 1.49713 0 7.99E-11 0.00659 0.12445 0 0.505432 0.024155 0.005383 1.733279

Wiley-Blackwell and Society for Applied Microbiology Page 62 of 848

uncultured CampylobacterTermite groupBacteroides 1 jejuni bacterium subsp.Thermotoga vulgatus phylotype doylei strainClavibacter sp.strain Rs-D17-08 TMO-08ATCC 269.97-08 8482-30 MethanococcusmichiganensisMyxococcus subsp. maripaludis michiganensisKlebsiella xanthus strain strainvariicolaSulfolobus C6-30 strain DK strain 1622-30 NCPPB islandicus At-22-08 382-01 strain Y.G.57.14-08 0 0.021038 0.037439 0.004666 0.000606 0 0.037595 0.003708 0 0 0 0 0 3.62E-08 0 0 0.004747 0 0 1.33E-14 0.011949 0 0.000223 0 0 0 0 0 0 0.026433 0 3.51E-07 0 0.015225 0.012275 0 0 0.000418 0.032924 0 6.69E-05 0 5.67E-08 0.007128 0 0 0 0 0 3.20E-05 0 0 0.011181 0 0 0.004195 0.067483 0 1.50E-05 0 0.010932 0 0 0 0 0 0 0.000284 0 0 0 0 0 For0 0.02012 Peer0 Review0 0 0.004237 Only 0 0 0 6.79E-10 0.000995 0.004339 0.000114 0 0.000262 0.007151 0 0 1.42E-06 0 0 6.10E-05 0 0 0 0 0 0 0.008283 0 8.05E-05 0 0 0.004108 0 0 0.002143 0.015806 0.00452 3.89E-05 0 0.010917 0.015295 0 0 0 0.012233 0 0.000587 0 0.000842 0 0.000314 0.004962 7.05E-12 0.052752 0 0.000162 0 0.031207 0.004844 0 0 9.26E-06 0.011899 0 5.46E-09 0 7.82E-13 0.002146 0 0.00024 4.40E-10 0.043126 0.000808 0.000297 1.46E-08 0.033943 0.010102 0 0 0 0.030629 0 1.14E-06 0 4.38E-05 0.007369 0 0 0.000438 0.013943 0 0 0 0.001512 0.010222 0

Wiley-Blackwell and Society for Applied Microbiology Page 63 of 848

MethanococcoidesThermotoga burtoniiProchlorococcus neapolitana str. DSMSynechococcus NS-E-08 6242-08 sp. NATL2A-01Synechococcus sp. strainYersinia JA-2-3B'a(2-13)-01 sp. RCC307-30 pestisDechloromonas strain Antiqua-30Silicibacter sp. RCB-01 Idiomarinapomeroyi DSS-3-01 loihiensis strain L2TR-30 0.022278 0.004094 0.001992 0.007214 0 0.045914 0.01699 0.128972 0.013735 0 0 0.001293 0.002918 0.301456 0 0.003283 0.057556 0 0 0 0.001365 0.001353 9.17E-05 0 0.002722 0.115464 0.062957 0 0 0.000231 0 0.000913 0.032494 0.005372 0.676087 0.458142 0.00258 0 0.002935 0.00036 0.041197 0 0.003475 0.2823 0.154279 0 0.006431 0.000493 0.000662 0.003468 0 0.007319 0.22626 0 0.005771 3.35E-23 0.002043 1.68E-06 0.084655 0 0.008403 0.193028 0.08593 0 0 0.003638 0.000784 0.060434 0 0.006732 0.212498 0 0.003614 For0 0.00215 Peer0.000101 0.036841Review0 0.001214 Only0.276789 0.228988 0.010675 0.00186 0.002133 0.002315 0.158881 0 0.006308 0.183914 0.109675 0.007649 0.000124 0.00517 0.000598 0.03951 0 0.007931 0.136894 0.169636 0 0 0.001073 5.82E-05 0.065063 0 0.003652 0.399937 0.809255 0.005003 0 0.002378 4.43E-05 0.011532 0 0.008934 0.586492 0.138324 0.003177 0 0.000713 0.001799 0.152156 0 0.003174 0.26223 0.085026 0.011648 0 0.004136 0.001265 0.016036 0 0.006818 0.130235 0.204845 0.004681 0 0.0006 3.81E-07 0.074101 0.00183 0.001946 0.21024 0.376233 0.006065 0.002209 0.00467 0.000285 0.005891 0 0.010593 0.108109 0.059614 8.38E-09 0 0.000469 0.00021 0.079038 0.000517 0.002009 0.158093 0.283427 6.70E-05 0 0.001777 1.95E-05 0.053052 0 0.007214 0.639112 0.232318

Wiley-Blackwell and Society for Applied Microbiology Page 64 of 848

PseudomonasPropionibacterium sp. AM1-08Frankia sp.acnes ListeriaEAN1pec-01 strain monocytogenes KPA171202-30MethanococcusMycobacterium strain maripaludis Clip80459-01Treponema ulcerans strainClostridium denticolaC5-08 strain Agy99-30 str.Methylobacterium thermocellum ATCC 35405-08 strain nodulans ATCC 27405-30 strain ORS 2060-30 0.01156 1.837301 0.009469 0 0 2.94E-10 0.020152 0.018952 0.022715 0.000707 0 0.000302 0.00652 0 0 0 0 0.000263 0.002597 0.019416 2.52E-05 0.000105 0 0 0 0 0 0.003747 0 0 0 7.11E-05 0.013049 0 0 0.019131 0.001405 2.91E-05 0.000155 0 0 0 0 0.002481 0.003464 0.001692 0 0.000403 0.004007 0 0 0 0 0 0.003856 0.180606 0.00029 0 0 0 0 0.011034 0.042597 0.012418 0.392106 0.000331 0 0 0 0 0 9.11E-15 0.002452 For0 0.000236 Peer0 Review0 0.001132 0.000379 Only0.008257 0.009434 0.002631 0 0.000577 0 0 0 0 0 0 0.00103 0.04238 0.000234 0 0 0 0 0 0 0.001249 0.055394 6.31E-05 0 0 8.88E-12 0 0 0.008311 0.003647 0 4.81E-06 8.98E-09 0.005426 0 0.007041 0 0.011337 0.001595 0 0.001134 0 0 9.30E-13 0 0 0.001969 0.00777 0 4.19E-06 0 0.000576 0 0.009542 0.017295 0.011103 0.001721 0.028126 0.000351 0 0 0.002875 0.001076 0.005983 0.009353 0.007194 0 0.000721 0 0 0.000489 0.003328 0.004978 0.010453 0.000745 0 1.65E-05 0 0 0 0 0.076349 0.000729 0.001161 0 0.000223 0.000214 0.005531 0.007674 0.00408 0 0.007767

Wiley-Blackwell and Society for Applied Microbiology Page 65 of 848

EdwardsiellaCoxiella ictaluri burnetii strainThermoanaerobacter 93-146-30 strainFrancisella RSA 331-08 sp. tularensisAcinetobacter X514-01 subsp.Acidobacterium baumannii tularensisCandidatus strain straincapsulatum AB0057-08 FSC198-08PhotorhabdusHodgkinia strain cicadicolaRhizobium ATCC asymbiotica 51196-01 strain etli strain Fischer-LeDsem-01 CFN 42-08 Saux et al. 1999 emend. Akhurst et al. 2004-08 0.386603 0 0 0 0 0.039689 0 0 0.017147 0.868275 0.021025 0 0 0.055846 0 0 0 0.009008 0.057196 0 3.36E-06 0 0 0.00018 0 0.010134 0.020013 0.227262 0 0 0 0.027089 6.19E-10 0 0.012132 0.023737 0.109907 0.02157 7.41E-12 0 0.015107 0.001444 0 0.007662 0.034951 0.481111 0 0 0 0.048995 1.91E-07 0.003055 0.019357 0.014558 0.084401 0 0 0 0 0.002256 0 0.004164 0.013229 0.227018 0 0.000459 0 0 6.32E-05 0 0.009719 0.026799 0.026134 For0 9.06E-05 Peer0 Review0 0.000932 Only0 0.005447 0.009902 0.232353 0 7.90E-05 0 0.021901 0.001475 0 0.011584 0.010221 0.516113 0 0.000222 0 0.035564 0.000891 0 0.006876 0.01406 0.126499 9.01E-07 0.0011 0 0.062158 0.001973 0 0 0.024467 0.177458 0 0.000242 0 0.037199 0.001427 0 0 0.019523 0.02752 0 0.00063 0 0 1.24E-05 0 0 0.001458 0.05974 0 0.002766 0 0 0.002603 0 0.010248 0.014167 0.038358 0 1.10E-16 0 0.010713 0.000799 0 0.004156 0.007013 0.055892 0.055445 0.002282 0 0.009405 0.00235 0 0.007485 0.015733 0.06623 0 0.000173 0.023442 0.01826 0.000129 0 0.003832 0.005009 0.11469 0 0.000282 0 0.05096 0.000181 0 0.010195 0.015218

Wiley-Blackwell and Society for Applied Microbiology Page 66 of 848

Nocardia farcinicaEdwardsiella strainXylella ictaluriIFM 10152-08fastidiosa strainAcinetobacter 93-146-08 strainFlavobacterium M23-30 baumanniiChlorobaculum strain johnsoniae AB0057-30Bartonella parvum strain bacilliformisProsthecochlorisUW101-01 strain NCIBEubacterium strain 8327-30 vibrioformis KC583-08 rectale DSM strain 265-30 ATCC 33656-30 0.008105 0.023485 0 0 0.036911 0.002325 0.059255 0 0 0.000357 0.025756 0 0 0.073415 0 0.033779 0.031417 0 0.000375 0.015398 0.061124 0 0.098318 0.006739 0.021552 0 0 0.002598 0.008918 0.062638 0 0.188515 8.98E-11 0.009322 1.74E-10 0.008454 0.000179 0.016786 0.031043 0 0.094869 0.004704 0.008158 0.009022 0 0.003414 0.017506 0.031717 0 0.275372 0 0.004936 0.081608 0 0.003333 0.009529 0.020141 0.006643 0.077591 0.048442 0 0.006661 0 0.004106 0.019001 0.191645 0 0.331671 0 0 0 0 0.000144 0.010346For0.049824 Peer0.036482 0.062714Review0.038262 Only0 0.001949 0 0.000946 0.021819 0.022251 0 0.148806 0.020551 0 0.034134 0 0.003848 0.026628 0.375537 0.081745 0.159577 0 0.007671 0 0.191174 1.71E-06 0.052798 0 0 0.147503 0 0 0 0 0.004192 0.050768 0.079743 0.005174 0.338115 0 0.018859 3.04E-07 0 2.34E-05 0.010005 0.052233 0 0.090338 0.016482 0 0.006137 0.000106 0.000499 0.007928 0.010455 0 0.060554 0.004567 0 0.011613 0 0.001416 0.002569 0.02478 0.011076 0.03558 0.003949 0.013795 0 0.006514 0.003456 0.009394 0 0.005179 0.128899 0.009896 0.037004 0.024314 0.006436 0.000692 0.008052 0 0 0.086789 0.017085 0.010092 0 0 0.002183 0.030958 0.03523 0 0.354481 0 0.043567 0.005276 0

Wiley-Blackwell and Society for Applied Microbiology Page 67 of 848

Rickettsia typhiMeiothermus str. Wilmington-08Methylococcus ruber strainHaloquadratum DSMcapsulatus 1279-08Photorhabdus str. walsbyi Bath-01Ralstonia strain luminescens DSM solanacearumAlcanivorax 16790-30 subsp.Kytococcus laumondiiborkumensis strain MolK2-01 Anaeromyxobacterstr.sedentarius strain TTO1-01 SK2-30 strain DSM dehalogenans 20547-08 strain 2CP-C-30 0 0.087329 0.078257 0 0.004003 0.000885 1.98493 0.035076 0.079333 0.035668 0.011506 0.005514 0 0.001962 0.000316 0.245934 0 0 0 2.09E-07 0.008859 0 0.000689 0.000771 0.215742 9.89E-06 0 0 0.00603 0.016804 0 0.002069 0.000409 0.582769 0.000167 0 9.24E-07 6.94E-12 0.016006 0 0.001526 3.92E-05 0.211415 0.004583 0 0 6.28E-05 0.02209 0 0.002204 0.001005 0.530534 0 0 0 0.001629 0.040984 0 0.000869 0.001093 0.207548 0.000372 0.00085 0 0.01974 0.03028 0 0.000943 0.000779 0.569016 0 0 0 1.74E-06For0.017165 Peer0 0.001036Review0.000338 0.243476 Only0.003508 0 0 0.003555 0.022652 0 0.001626 0.000776 0.314108 0.001388 3.22E-15 0 0.012568 0.026648 0 0.001233 0.000291 0.412916 0.000898 0 0 0 0.015081 0 0.001694 2.39E-05 0.659794 0.005108 0 0 0.009786 0.041546 0 0.003589 0.001546 0.439791 0.005519 0 0.013311 0.013456 0.013485 0 0.000736 0.000106 0.097943 0 0.011069 0 0.007524 0.034368 0 0.000909 8.18E-05 0.391966 0.007976 0.019049 0.019659 0.016504 0.011611 1.04E-05 0.000612 4.85E-06 0.409936 0.000451 5.36E-07 0.004859 0.020887 0.043308 0 0.001169 0.001891 0.428092 0.003335 0.016569 0 0.003453 0.004001 0 0.000313 4.77E-05 0.361142 0.000124 0 0 0.000483 0.036208 0 0.002003 0.002355 0.385173 0.00468 0

Wiley-Blackwell and Society for Applied Microbiology Page 68 of 848

Wautersia metalliduransBacillus thuringiensisMagnetospirillum CH34-01 strainEscherichia Al sp. Hakam-01 AMB-1-08 Mycobacteriumfergusonii strainClostridium gilvum ATCC Aminobacterium 35469-01 acetobutylicumstrain PYR-GCK-08Corynebacterium straincolombienseRhizobium ATCC 824-08efficiens strain leguminosarum DSM strain 12261-01 YS-314-30 bv. trifolii strain WSM2304-30 0.010441 0.000555 0.437808 0.002452 0.012043 0.00017 0.002736 0.000911 0.007453 0.000876 0 0.037086 0.000145 1.70E-11 0.008432 0.000154 0 0.008437 0.001839 2.25E-05 0.077523 0.000101 0.000473 0 0 0 0.000837 0.004397 2.23E-06 0.037997 0 0.000475 0 2.75E-09 0 0.009512 0.001295 0.000149 0.027931 0.000387 1.77E-05 0.000191 4.61E-08 0 0.00844 0.003961 9.92E-11 0.036284 0.001312 0.00135 0 9.07E-05 0 0 0.005527 0.000167 0.278322 0.000932 0.000131 0 1.31E-05 0 0.009635 0.004606 1.81E-07 0.061901 0.001897 0.000119 0 0 0 0.071775 0.001793 For0 0.032444 Peer0.000153 0.000502Review0 Only0 0 0.003682 0.002127 4.55E-05 0.041505 0 0.000227 4.24E-06 0 2.64E-19 0.000242 0.00337 0.000145 0.041967 0.001089 9.31E-07 9.11E-09 0 0 0.007386 0.001687 0 0.04464 0.000443 5.70E-10 0 6.23E-12 0.006397 0.002851 0.004986 0.000157 0.033968 0.003691 0.00081 0 4.66E-06 0 0.005669 0.001754 0 0.034052 6.01E-06 1.58E-05 0 0 0 0.002506 0.005554 0 0.400712 0.00196 0.000354 0 0.002124 0 0.006643 0.001257 0.000168 0.041236 0.000246 0 1.94E-09 0 0 0.008399 0.004026 0.000136 0.333365 0.002503 0.00112 0.00203 0.002455 0.003021 0.006991 0.000478 3.41E-05 0.016752 0.00047 0.0013 1.20E-06 0.001082 0 0.010209 0.004071 0 0.033443 0.002055 0.001302 4.07E-07 0 0 0.010417

Wiley-Blackwell and Society for Applied Microbiology Page 69 of 848

SphingobiumNocardioides japonicumHydrogenobacter strainsp. JS614-08 UT26S-30Sulfurospirillum thermophilusFlavobacteriaceae deleyianum strainEscherichia TK-6-30 strain bacterium Rhodobactercoli DSM O157:H7 6946-303519-10-01Klebsiella capsulatusEDL933-30 variicolaBrucella strain strain SB1003-08suis strain At-22-01 ATCC 23445-01 0.166277 0.015907 0 0 0.014678 0 0.066157 0.001766 0 0.309391 0.006583 0 0 0.022678 0 0.229809 0.00023 0.000566 0.057266 0.005097 0 0 0.025879 0 0.503278 0.000383 0 0.060266 0.000348 0 0 0.059685 0 0.681049 0 0 0.051776 0.002939 0 0 0.031597 0 0.443206 0.00154 0 0.000117 0.000326 0 0 0.066798 0 0.455001 0 0.008519 0.108941 0.003713 0 0 0.027834 0 0.222881 0.001593 0.007758 0.558035 8.88E-06 0 0 0.089252 0 0.318263 0 0 0.015235 0.004589For0.031852 Peer0 0.021071Review0 0.216443 Only0.000493 0.006522 9.95E-05 1.19E-05 0 0 0.041651 0 0.269145 0.001064 0.007849 0.100274 0.001899 0 0 0.059495 0 0.231132 0.001752 0 0.036547 0.000526 0 0 0.043954 0 0.509468 0 0 0.022549 0.004272 0 0.003069 0.100462 0 0.545936 0.004278 0 0.005141 0 0 0 0.031568 0 0.077251 0.000365 0.007511 0.055619 0.014861 4.25E-13 1.25E-07 0.025535 0 0.255324 0 0 0.04274 0.000187 0 0 0.008175 0.002852 0.173148 0.000781 0 0.012292 0.012631 0.001806 0.000361 0.040385 0 0.19022 0 0 0.009466 0 0 0.06376 0.022667 0 0.53022 0.000223 0 0.034488 0.001218 0 0 0.075426 0.000768 0.638186 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 70 of 848

Bacillus weihenstephanensisSalinibacterBordetella ruber strainAnton parapertussisGloeobacter KBAB4-01 et al. 2002-30Rhodococcus violaceus strain 12822-30 Rhizobiumstrain erythropolis PCC 7421-01leguminosarumLawsonia strain intracellularisPR4-30Leifsonia bv. trifolii xyliCoxiella strain subsp. strain PHE/MN1-00-30 burnetii xyli WSM2304-08 strain strain CTCB07-30 CbuG_Q212-30 0.001681 0 0.010398 0.024024 2.41E-06 0.011639 0 0.086703 0.126863 2.93E-15 0 0.009017 0.000664 0.000922 0.007206 0 0 0 0.000324 0.009744 0.002003 5.72E-05 1.41E-08 0.010324 0 0.02526 0 0 0 0.003628 0.000135 0.017404 0.009768 0 0 0 0 0.005978 0.011138 7.64E-05 0.000411 0.013625 8.12E-07 0 0 0 0.042231 0.010424 0.002305 0.002294 0.01637 0 0 0 5.44E-05 0.002225 0.00925 0.003791 0.013412 0.009749 0.029943 0 0 4.24E-05 0 9.53E-06 0.000567 0 0.016549 0 0 0 1.00E-07 0.000845For0.002737 Peer0.000686 0.003469Review0.005939 Only0 0 0 8.98E-05 0 0 0.001402 0 0.007114 0 2.05E-21 0 0.00051 0 0.01452 0.001539 0 0.00709 0 0 0 0 0 0 0.000615 0 0.019229 0 0.031672 0 0 0 0 0.000171 1.25E-07 0.020913 0 0 0 0.000317 0 0 0.003149 0 0.007319 0 0 0 0.001374 0.013126 0.01142 0.001528 0.001418 0.010352 0 0 0 8.16E-05 0.002182 0.001953 0.000117 0.005664 0.004606 0 0.014201 0 0.000717 0.012792 0.006884 0.002266 0.000221 0.010075 0.023374 0.018079 0.047044 8.56E-06 0 0.033057 0.000162 1.14E-05 0.005946 0 0.056639 0 0.000101 0 0.012094 0.000551 0.003146 0.015802 1.11E-17 0.031945 0

Wiley-Blackwell and Society for Applied Microbiology Page 71 of 848

Xylella fastidiosaHirschia strain balticaGordonia M12-30 strain bronchialis ATCCMycobacterium 49814-08 strainKlebsiella gilvumDSM pneumoniae43247-01Prevotella strain PYR-GCK-01 ruminicolaEnterobacter strain 342-01 strainRickettsia cloacae 23-08 conoriisubsp.Bartonella cloacaestrain tribocorum Malish strain 7-01ATCC strain 13047-01 CIP 105476-30 0 0.064761 0.00182 0.001942 0 0 0.033001 0.013389 0.001956 0.16538 0.035439 0.000176 0 0.000244 0.019421 0 0.001189 0.04121 0.003196 0.038268 0.000292 0.001267 0.000251 0.01744 0 0 2.08E-05 0.018666 0.039218 5.03E-05 0 0.000302 0.013021 0 0 0.020702 0.013782 0.0435 0.001304 0.000439 0 0.012713 0 0 0.008803 0.0669 0.068404 0.00013 0.000788 0.000937 0.000355 0 0 0.078668 0.007457 0.055908 0 0.000621 0 0.007505 0 0.001402 0.005855 0 0.074049 4.83E-05 0.000123 0.000669 0.011125 0 0.000322 0 0.018179 0.046915For0.001732 Peer0.000342 Review0 0.001467 Only0 0 0.020092 0.015346 0.046164 0.00076 5.80E-05 0 0.008878 0 0 5.77E-19 0.012951 0.069239 1.26E-05 2.10E-05 0.000888 0.009218 0 0.003634 0 3.72E-12 0.031489 0.001562 0.000157 0.001801 0.002352 0 0 1.02E-17 0.002098 0.098226 0.00077 7.89E-05 0 0.006031 0 0.000391 0.004406 0 0.01368 0.000356 0.000475 0.000609 0.002067 0 0 2.59E-06 0.007064 0.06298 2.76E-05 8.68E-05 0.000702 0.026207 0 0 0.000812 0.002589 0.034632 0.000815 0.00011 0 0.004263 0 0 0.009952 0.002774 0.052188 0.000352 0.000141 0.001089 0.008691 0 0 0.002439 0 0.039163 0.000552 0.00012 0.00019 0.006309 0 0 0.012031 0.003221 0.069195 0.001366 0.001093 0.002257 0.005599 0 0.000175 2.01E-19

Wiley-Blackwell and Society for Applied Microbiology Page 72 of 848

Geobacter sulfurreducensBacillus cereusStreptococcus strain PCA-3003BB102-30Geodermatophilus suis strainAciduliprofundum BM407-08 obscurusChromohalobacter strain booneiStreptococcus DSM strain 43160-30 salexigens T469-01Tropheryma uberis strain str.Chlamydophila whipplei DSM0140J-01 3043-30 str. TW08/27-30 abortus str. S26/3-08 0.047508 0 0 0.008454 0.082316 0.182817 0 0 0.000176 0 0 0 0 0 0.18526 0 0.884158 0 9.38E-08 0.000283 0 0.000193 0 0.237258 0 0 0 0 0 0 0.040792 0 0.513146 0 0 0 0.014181 0 0.005784 0.000544 0 0.139373 0 0.098973 0 0 0 0 0 0 0.44351 0.003146 0 0 0.012402 0 0 0.014591 6.07E-09 0.14869 0.00018 0.099877 0 0.008306 0 0 0 1.23E-10 0.238966 0 2.130992 0 7.56E-09 0.001648For Peer0 0.007162 Review0 0.220398 Only0 0 0 0 0.0002 0 9.53E-16 0 0.436619 0 0 0 2.83E-19 0 0 0.039463 1.67E-06 0.298989 0 1.424479 0 0 0.001014 0 0 0 0.29367 0 0.1768 0 0 0 0 0 0 0.204054 0 0 0 0.000221 0.010184 0 0 0.005072 0.055517 0 0 0 0.02526 0.010402 0 0.012791 0.003077 0.129543 0 0 0 0.000915 0 0 1.17E-22 0.001445 0.16097 0 0 0 0.022566 0.001213 0 0.020439 0.011096 0.081047 0 0 0 0 0 0 0.000131 0 0.164753 0 0.476455 0 0 0 0 0.000743 0 0.282804 0 0.540362 0

Wiley-Blackwell and Society for Applied Microbiology Page 73 of 848

Wautersia taiwanensisThermococcusSalmonella (Chen kodakarensis et al. Streptococcusenterica 2001) strain Vaneechoutte subsp.Francisella KOD1-08 sanguinis enterica ettularensisStreptomyces strainserovaral. 2004-08 SK36-01 subsp.GallinarumKineococcus-like coelicolor tularensis strainRhodopseudomonas A3(2)-01 strain 287/91-08str. SRS30216-30 SCHUMethylobacterium S4-08 palustris strainsp. CM4-01 BisB18-30 0.021212 0.004689 0 0 0 0.004119 0 0.171816 0.002473 0.008703 0 0 0 0 2.79E-05 0 0 0.0005 0.00451 0 0 0 0.016571 0 0.000668 0.016249 0.001525 0.008984 0 0 0 0 0 0 0.027133 0.001182 0.006047 0 0 0.000466 0.011786 0.000424 0.002229 0.003992 0.001277 0.007898 0 0 0 0 0.000391 0 1.07E-06 0.000955 0.010316 1.08E-12 0 0 0 0.000566 0 0.002642 0.001324 0.009358 0 0.010004 0 0 7.82E-05 0 0.054068 0.001249 0.004011 For0 Peer0 0 Review0 6.13E-05 0.004092 Only0.006619 0.001795 0.011563 0 0 0 0 7.59E-06 0.024841 0.005142 0.000556 0.016554 0 0 0 0 0.000449 0 0.000676 0.001608 0.000881 0 0.003888 0.000721 0 0.000165 0 0.002811 0.001311 0.020814 0 0 0 0.083725 0.000352 0 0.00593 0.001704 0.000534 0.007009 0.001287 0 0 0.000253 4.90E-09 0.003436 0.002151 0.01404 1.86E-08 0 1.95E-05 0 0.000327 0.013021 0.003613 0 0.00287 0.004088 4.03E-08 0.000519 0 0.000173 0.004559 0.011249 0.001457 0.012524 0.000538 0 0 0 0.000364 0 0.021857 0.001459 0.006185 0 0 0 0 3.42E-14 0 0.023317 0.000454 0.016326 0 0 0 0 8.17E-05 4.30E-11 0.000195 0.001661

Wiley-Blackwell and Society for Applied Microbiology Page 74 of 848

MethylobacillusPsychrobacter flagellatusGeobacter cryohalolentis strain bemidjiensisKT-30Streptococcus strainShewanella strainK5-08 pyogenes Bem-01Aminobacterium sp. strain WP3-08 MGAS2096-08Bartonella colombiense quintanaMycobacterium strain strainActinosynnema DSM Toulouse-08 tuberculosis 12261-30 mirum strain strain KZN 1435-01 DSM 43827-01 0 0.388649 0.012013 0 0.019484 0 0 0.000819 0.006002 0.009928 0.082646 0.000168 0 0 0 0.003646 0.000123 4.36E-06 0.027197 0.019247 2.55E-05 0 0.010656 0 0 0 0.000201 0.050627 0.034974 3.16E-06 0 0.049625 0 0 0 0 0.003001 0.010611 0.000187 0 0.013881 0 0.017046 0 6.13E-05 0.126543 0.062347 0.00032 0 0.098851 0 0.004134 0 1.54E-05 0.035672 0 0.002001 0 0.02109 0 0.019603 0.0002 4.25E-05 0.017861 0.084315 0.000339 0 0.043101 0 1.53E-05 0 0.000311 0.020963 0.011899For0.000115 Peer0.002013 0.012361Review0 0.032716 Only 0 2.40E-06 0.000299 0.04715 0.000562 0 0.052037 0 0.016017 1.94E-05 8.30E-07 4.59E-09 0.111853 0.001547 0 0.068894 0 0.009076 8.23E-05 2.29E-05 0.086358 0 0.00011 0 0.035953 0 0 0 0.000284 0.065979 0.09499 0.000295 0 0.077082 0 0.007733 0.000122 0 0.032807 0.004044 0.000437 0 0.006793 0 0 0 0.000276 0.133011 0 0.002898 0 0.031804 0 0 0.000465 0.000326 0.040498 0.012994 0.000212 0 0.013283 0 0.017448 0.001122 9.40E-05 0.013168 0.048533 0.002632 0 0.024254 0.001347 0.020251 0 4.04E-05 0 0.015886 0.000207 0 0.029368 0 0 2.39E-07 0 0.045651 0.08165 0.00138 0 0.056828 0 0 0.000153 2.16E-08

Wiley-Blackwell and Society for Applied Microbiology Page 75 of 848

RobiginitaleaMycobacterium biformataSinorhizobium strain vanbaalenii HTCC2501-08Mycobacterium meliloti strainTrichodesmium (DangeardPYR-1-30 abscessus Clostridium1926) strain sp. De IMS101-30 Lajudie ATCCBlattabacterium difficile 19977-08 et strainal.Bacillus 1994-01 CD196-30 sp. cereus (PeriplanetaPicrophilus ATCC 14579-30 americana) torridus strain strain DSM BPLAN-08 9790-01 0.273875 2.17E-15 0 0.000974 0 0 0 0 0.010503 2.256663 0.095797 0 0.000637 0.320168 0 0 5.06E-11 0 1.913123 2.10E-06 0 2.87E-05 0.019007 0.072459 0.036 0 0 1.290986 6.08E-07 0 0.003152 0.006303 0.235377 0 0 0 1.518632 0.0025 0 0.001904 0.016229 0.105824 0.032232 0 0 2.12606 0.005733 0 0.006954 0.043462 0 0.031652 0 0 0.872298 0 0 0.00014 0.02261 0 0.000758 0 0 3.070614 0.125665 0 0.001083 0.181578 0 0 0 0 0.944304 0.000189For Peer0 0.000874 0.02464Review0 Only0 0 0 2.546001 0 0 0.005353 0.108205 0.247861 0.082842 0 0 1.545596 9.50E-07 0 0.008983 0.044595 0.628419 0 0 0.001222 1.713817 0.001402 0 0.00989 0.005981 0 0 0 0 2.004009 0.01662 0 0.005575 0.106121 0 0.104645 0 0 0.266898 0.008549 0.014378 2.94E-05 0.044451 0 0.015125 0 0.001187 0.939103 0.000906 0 0.003569 0.013091 0 0 0 6.48E-05 0.239733 0.000703 0 0.001361 0.029068 0.03777 0 0 6.68E-05 0.643278 0.000916 0 0.004739 0.014136 0 0.10305 0.001075 0.000144 1.298321 0 0 0.004275 0.074526 0.046091 0 0 0 1.766718 0 0 0.009103 0.086085 0 0.09984 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 76 of 848

MycobacteriumRalstonia bovis pickettii BCGPsychrobacter strain strain TokyoRickettsia 12J-01 sp. 172-30 PRwf-1-30 akariNostoc strain sp. Hartford-01PCCChlamydophila 7937-08Pseudomonas pneumoniaeMagnetococcus aeruginosa J138-01Coxiella str. sp. UCBPP-PA14-08 MC-1-08burnetii strain Dugway 5J108-111-01 0 0.003188 0 0.009754 0.005602 0 0.020623 0.073663 0.022679 0 0.002133 0 0 0.006465 0.003097 0.105248 0.007924 0 0 0.000953 0.01228 0.003361 0.013006 0 0.0333 0.005905 0 0 0.00063 0 8.33E-05 0.005691 0 0.062821 0.010223 0 0 0.000955 0.02272 0 0.003605 0 0.021979 0.009537 0.012766 0 0.001856 0.097485 0 0.001238 0 0.106876 0.024947 0 0.004711 0.00183 0.036706 0 0.016565 0 0.038896 0.036202 0 0 0.000856 0 0.001175 0.019688 0 0.096791 0.026334 0 0.001996 0.000972For Peer0 0.000842 0.000254Review0 Only0 0.00434 0.00561 0 0.000853 0.001819 0 0.005345 0 0.085773 0.017099 0 0 0.001643 0 0.006154 0.0048 0 0.123865 0.032317 0 0 0.002554 0.007764 0 0.007993 0 0.071613 0.043283 0 0 0.003157 0.052535 0 0.008842 0 0.159962 0.023434 0 0.000161 0.00089 0 0 0.005664 0 0.00827 0.003265 0.005334 0 0.001046 0.091184 0.004314 0.009807 0 0.049634 0.048592 0 0 0.001442 0.033456 0.003716 0.007658 0 0.027602 0.009358 0 0.001423 0.003303 0.027607 0.001944 0.003663 0 0.034225 0.025357 0.015008 0 0.000238 0 0.00281 0.004436 0 0.031497 0.009381 0.002109 0 0.002642 0 0.002417 0.006722 0 0.129786 0.015349 0

Wiley-Blackwell and Society for Applied Microbiology Page 77 of 848

ChlorobiumChitinophaga tepidum strainClostridium pinensis TLS-08 Kineococcus-likestrain sp. OhILAs-08 DSM Geobacillus2588-01 str. SRS30216-08Clostridium thermodenitrificansStreptomyces botulinum strain AeromonasA strainrochei NG80-2-30 ATCC BergerMethanococcus salmonicida 3502-30 et al. 1953-01 subsp. vannielii salmonicida strain SB-08 strain A449-30 0.051656 0.013004 0.0254 0.006554 0.038638 0 0.007887 0 0.018978 0.039542 0.002299 0.022057 5.97E-10 0 0 0 0.031178 0 0.006078 0.003599 0.004086 0.004973 0 0 0 0.000328 5.83E-05 0 0.006588 0 0.000301 0 0 0 0.060476 0 0.002128 0.003114 9.03E-06 8.99E-05 0 0 0 0.010923 0 0 0.006955 0.010321 0 0 0 0 0.001936 0 0.012236 0.003566 0.00265 0.004583 0 0 0 0.029007 6.59E-05 0.028656 0.006184 0 0 0 0 0 0.008279 0 0 0.003611For Peer0 0.002539 1.29E-11Review0 Only0 0.066319 0 0.008124 0.006381 0.011079 8.45E-10 0 0.006783 0 0.061864 0.005535 0.007427 0.008451 0.002149 0 0 0 0 0.018192 0 0 0.005178 0 8.32E-07 0 0 0 0.118539 0 0.018636 0.012588 4.17E-05 0.000456 0.000922 0 0 0.043442 0 0 0.003196 0 0 0 0 0 0.007149 0 0 0.005314 0 0.006292 0 0 0 0.029307 0 0.004417 0.002758 0.000608 0.000958 1.57E-05 0 0 0.02934 0 0.006245 0.006305 0.011681 0.000913 0.019495 0 0 0.012286 0.003292 0.005231 0.00137 0 4.85E-19 0 0 0 0.057256 0 0.00768 0.008916 0 0.001058 0 0 0 0.031857 0

Wiley-Blackwell and Society for Applied Microbiology Page 78 of 848

Nocardia farcinicaMethanocaldococcus strainShewanella IFM 10152-01 fervensBrachybacterium sp. WP3-01 strainSulfurovum AG86-30 faeciumCampylobacter sp. strain NBC37-1-01 DSMThermocrinis 4810-01jejuni strainCampylobacter albus RM1221-01 strainCoraliomargarita DSM lari strain14484-01 RM2100-30 akajimensis strain DSM 45221-30 0.006565 0 0.006892 0.00097 0.00015 0 5.44E-05 0 0.224969 0.0002 0 0.003218 2.85E-22 0.001483 0.000517 0 0 1.52781 0.000987 0 0.003646 8.73E-06 0.001598 0.000221 0 0 0.167677 0.002192 0 0.004848 0 0.00016 0 0 0 0.434269 0.000102 0 0.002641 3.54E-05 0.003313 0 0.00075 0 0.060494 0.000706 0 0.011598 8.75E-07 0.002824 0 0 0.238606 5.170489 0.000461 0 0.009069 2.87E-05 0.004547 0 0.003947 0 0.695626 0.00196 0 0.009376 0.000162 0.004437 0.000103 0 0 4.866156 0.000838 For0 0.003917 Peer0 0.003001Review0.000376 Only0 0 0.069315 0.000601 0 0.008934 1.01E-05 0.00139 2.48E-12 0 0.000314 0.877582 0.001481 0 0.006288 0.000815 0.00467 0.000308 7.90E-06 0 2.019737 0.000933 0 0.004345 1.54E-05 0.002091 0 0 0 0.085551 0.001091 0 0.017269 7.31E-06 0.007526 1.88E-13 6.91E-10 0 0.473327 0.000528 0 0.001633 0.00042 0.000621 1.76E-06 0.000289 3.73E-05 0.103632 0.000157 0 0.00811 2.14E-06 0.004188 0.000313 0.000768 0.017442 0.332771 0.000881 0 0.001056 0.000114 1.70E-05 0.000417 0 0 0.231422 0.001189 0.001209 0.006056 5.56E-05 0.00311 0 0.000329 0.01667 0.264266 8.15E-05 0 0.001777 0 0.00033 0.000202 4.80E-05 0 0.36653 0.000475 0 0.017148 8.71E-07 0.003612 7.80E-14 8.11E-05 0 0.366748

Wiley-Blackwell and Society for Applied Microbiology Page 79 of 848

DesulfovibrioBrucella vulgaris abortus vulgarisRhizobium bv. (strain 1 strainleguminosarumBifidobacterium Hildenborough)-30 9-941-30Escherichia bv. adolescentis trifolii Shigellacoli strain O26:H11 strain dysenteriae WSM1325-30Mycobacterium ATCCstrain 15703-30 11368-08 strainAzoarcus Sd197-01 ulcerans sp.Bartonella EbN1-08 strain Agy99-08 bacilliformis strain KC583-01 0 0 0.028941 0 0 0 0.002068 0.033124 0.002222 0 0 0 0 0 0 0.003315 0.0157 0.000634 0 0 0.001285 0 0 0.000498 0 0.009469 0.000822 1.22E-09 0 0.018305 0 0 0 0.001607 0.004768 0.006107 0 0 0.006812 0 0 0 1.59E-05 0.00613 0.009695 0 0.050856 7.62E-05 0 0.002431 0 0.001338 0.028143 0 0.003393 0 0.001948 0 0 0.000597 0 0.022387 0.009421 0 0 0 0 0 0.000831 0.00027 0.048181 0.01203 0.005767 0.000192For0.006742 Peer0 Review0 0 0.000265 Only0.004918 0.01461 0 0 0.000121 0 0 0 0.001017 0.022283 0.004889 0.001246 0 0.034662 0 0 0 0.001856 0.040282 0.010724 0 0 6.39E-05 0 0 0 0 0.007242 0.003181 0 0 0.027315 0 0 0.000249 0.004934 0.040934 0.004986 1.45E-05 0 0.002573 0 3.09E-05 0 0 0.002458 0.018642 0.001298 0 0.003295 0 0 0.001062 2.17E-06 0.013167 0.01139 0.013385 0 0.002688 0.003665 0.000954 1.56E-05 0.000101 0.010785 0.011639 0.012209 0 0.006767 0 0 0 0.000562 0.020762 0.006639 0.012812 0 0.00119 0 0 0 0.001136 0.006078 0.002127 0 0 0.005325 0 0 0 0.007617 0.048383 0.005191

Wiley-Blackwell and Society for Applied Microbiology Page 80 of 848

Rickettsia rickettsiiEnterococcus strainShewanella faecalis 'Sheila Smith'-30str.Thermotoga baltica V583-30 strainEscherichia neapolitana OS155-08 Thermocriniscoli NS-E-01 strain UTI89-08Streptococcus albus strainCandidatus DSMthermophilus 14484-30 BacillusHamiltonella strain anthracis LMD-9-01 defensa strain strain CDC 5AT684-30 (Acyrthosiphon pisum)-01 0 0 0 0.00031 0 0 0 0.000186 0 0 0 0 0 0 0 0 7.25E-05 0 0 0 0 0 0 0 0 0.000488 0 0 0 0.014781 0 0 0 0 0.000311 0 0 0 0.005042 0 0 0 0 0.007163 0 0 0 0.025116 1.07E-09 0 0 1.81E-06 0.004498 0 0 0 0.010909 0.000221 0.000127 0 0 0.00225 0 0 0 0.02999 0.000643 0 0 0 0.003991 0 0 For0 0.014798 Peer2.96E-05 Review0 0.010333 Only0 0.002987 0 0 0 0 8.19E-09 0 0 0 0.001054 0 0 0 0.017155 3.93E-09 0 0 0 0.004171 0 0 0.000686 0 0 0 0 0.000289 0.001214 0 0 0 0.035596 1.13E-06 0 0 0 0.005295 0 0 0 0 3.26E-06 0 0 0.001396 0.00056 0 0 0.003746 0 0.004566 0 0 0 0.001455 0 5.42E-05 0 0 4.98E-15 0 0 0 0.000334 0 0 0.001283 0.006161 0.000513 0 0.004266 1.10E-11 0.005795 0.000908 0 0 0.012877 5.85E-09 0 0 0 0.001095 0 0 0 0.015743 0 0 0 0 0.004095 0

Wiley-Blackwell and Society for Applied Microbiology Page 81 of 848

Rickettsia typhiCaulobacter str. Wilmington-01Leptospira segnis strain borgpeterseniiListeria ATCC welshimeri 21756-30Streptobacillus serovar serovar BifidobacteriumHardjo-bovis moniliformis 6b strainMethanococcus strainSLCC5334-08 animalis strain L550-08Prosthecochloris DSM subsp. maripaludis 12112-01 lactisBorrelia strain aestuariistrain sp. Bl-04-01 PBi-01C7-01 strain DSM 271-08 0.015626 0.005457 0.023644 0 0.006706 0 0.000312 0.055616 0 2.86E-06 0.002971 0 0 0.000132 0 0 0 0 0.001219 0.001469 0 0 0 0 0 0.009837 2.29E-12 9.31E-05 0.039893 0 0 0 0 0 0.001715 0 0.003569 0.01294 0.005181 0 0 0 0 0.007452 6.62E-12 0.004686 0 0 0 0.001867 0.001503 0 0.015046 0 0.0046 0.004775 0 0 0 0 0 0.013811 0 0.001091 0.025458 0 0.000269 5.76E-07 0 0 0.018971 2.56E-14 0.00839 0.002715For Peer0 0 4.79E-05Review0 Only0 0.00318 0 0 7.43E-17 0.00039 0 0 0 3.18E-05 0.01162 0.000474 0.002876 0 0.000166 0 0.000352 0 2.80E-05 0.009939 1.71E-09 0.000863 0.015716 0 0 0 0.000133 0 0 1.70E-10 0.000296 0.008211 0 0 8.42E-09 0 0 0.025418 0 0.005368 0.006225 0 0 0.000535 0 0 0.006498 0 0 0.051643 0 0.000333 0.000438 0 0.003028 0.007814 2.93E-14 0.003764 0.002655 0 0 0 5.23E-05 0 0.004308 6.06E-11 0 0.017314 0.006304 0.000628 0.000176 0 0.001331 0.027547 0 0 0.013472 0 0 0 0 0 0.003109 0 0.00331 9.98E-06 0 0 1.65E-06 0 0.00064 0.008811 2.49E-11

Wiley-Blackwell and Society for Applied Microbiology Page 82 of 848

Salmonella Rhodospirillumenterica subsp.Kytococcus rubrumenterica Magnetospirillumsedentarius strain serovar ATCC ParatypiStackebrandtia strain 11170-08 sp. DSMA str. AMB-1-01Ehrlichia 20547-01 ATCC nassauensis 9150-08 canisStaphylococcus strain strain Jake-01 AzoarcusDSM aureus 44728-01 sp.Burkholderia subsp. EbN1-30 aureus thailandensis COL-30 strain E264-30 0 0.302606 0.005683 0.121159 0.002482 1.27E-08 0 0.001136 0 0 0.045153 8.93E-21 0.007656 0 0.002889 0 0 0 0 0.069908 0.000143 0.005445 0.000332 0.001071 0 0.009227 2.16E-11 0 0.021223 0 0.006858 8.14E-14 6.25E-23 0 0.092797 0 0 0.02213 0.000679 0.010999 0.000444 0.001483 0 0.011907 0.006939 0 0.032348 0.000275 0.011143 0.000705 1.22E-05 0 0 0 0 0.196506 0.000111 0.050797 2.39E-05 3.39E-05 0 0.00617 0.013756 0.000279 0.058202 2.99E-05 0.015278 0.000219 0.001369 0 0 0.003002 0 0.026442For Peer0 0.017416 0.000542Review0.001468 Only0 0.022441 0.003484 0 0.029311 0.00099 0.00553 8.76E-11 2.20E-07 0 0.052094 0.000803 0 0.023689 8.43E-07 0.011395 0.000501 0.001293 0 0.073454 0.032102 0 0.029773 0.000158 0.016683 0.000135 0.000545 0 0.008404 0.006775 0 0.042656 8.14E-05 0.007712 5.87E-05 0 0 0.016995 3.80E-09 0 0.029968 0.001587 0.019546 0.00019 0.003519 0 0.00543 0 0 0.22829 0.000575 0.031486 0.000199 0 0 0.070842 0.01304 0 0.041117 0.000394 0.017173 0.000408 0.000823 0 0.022525 0.008196 0 0.225268 0.000191 0.027829 0.000914 0.002752 0.002762 0.010861 4.27E-05 0 0.010763 7.26E-13 0.005857 0.000323 1.67E-05 0 0.000161 0.012607 0 0.036657 0.00035 0.011952 4.51E-05 0.000483 0 0.022942 0.001302

Wiley-Blackwell and Society for Applied Microbiology Page 83 of 848

LactobacillusSphingopyxis plantarumMethanothrix strainalaskensis JDM1-01Mycoplasma strain thermophila RB2256-01Thermoanaerobacter penetrans PT-30 Burkholderia strain HF-2-08 italicusStaphylococcus cepacia strain AMMD-01Anaplasma Ab9-08 saprophyticus Yersiniamarginale subsp. pestis subsp. saprophyticusstrain centrale Nepal516-30 str. strain Israel-01 ATCC 15305-08 6.59E-06 0.009899 0 0 0 0.00155 0.001156 0.009495 0 0 0.001875 0 0 0 0.000289 0 0.000115 0 0 0.002975 0 0 0 0.000156 0 0.000216 0 2.74E-10 0.014681 0 0 0 0.000826 0.002218 0.006846 0 0.000121 0.005646 0 0 0.000854 0.000351 0 0 0 5.51E-09 0.003366 0 0 0 0.001084 0 0 4.07E-06 0 0.00599 0 0 0.004795 0.000996 0.004645 0.003179 0.013433 8.07E-14 0.001988 0 0 0 0.000562 0 1.17E-05 0 0 0.007284For Peer0 0 Review0 0.000597 0.003423 Only 0 0.000959 0 0.002387 0 0 0 0.000331 0.000468 0 0.010019 7.01E-06 0.006702 0 0 0 0.000143 0 0 0 0 0.006975 0 0 0 0.000163 0 0 0.010449 0 0.002813 0 0 0 0.00016 0 0 0 0 0.007375 0.004184 0 0 0.000444 0 0 0 0 0.002596 0.001032 0.006264 0.000106 0.00072 0 0.002318 0 0 0.007071 0 0 0.002597 0.000225 0 0 0 0 0.005675 0.020723 0 0.009681 0.001505 0 0 0.003604 0 0.001352 0 0 4.63E-09 0.000249 0 0.000426 0 0 0.004212 0 0 0 0.000265 0 0 0.003664

Wiley-Blackwell and Society for Applied Microbiology Page 84 of 848

Wautersia eutrophaEscherichia H16-01 Salmonellacoli strain ED1a-01 Shigellatyphi CT18-30 flexneriRalstonia serotype pickettiiChromohalobacter 2a str. strain 2457T-01Lactobacillus 12J-08 salexigensNitrobacter helveticus strainAcinetobacter winogradskyi strain DSM DPC3043-08 4571-01 sp.strain ADP1-30 Nb-255-30 0.006842 0 0 0 0.018245 0.239674 0 0.011048 0 0.002089 7.03E-05 0 0 0.007402 0.577271 0 0 0.113749 0.001909 2.60E-06 0 0 0.002742 0.237081 0 0.009169 0.040366 0.001471 0.002102 0 0 0.016776 0.306307 0 0.033922 0.131703 0.001822 0 0 0 0.002748 0.081755 0 0.054284 0.03552 0.004355 0.000385 0 0 0.023498 0.665192 0 0 0.046063 0.005753 0.001566 0 0 0.017045 0.199496 0 0.03371 0 0.004428 0.001408 0 0 0.015153 0.525538 0 0.000762 0 0.002357 0.000744For0.001519 Peer0 0.002599Review0.094457 Only0 0.02524 0 0.003043 0 0 0 0.007391 0.42684 0 0 0.01429 0.001809 0 0 0 0.009757 0.582435 0 0.134847 0.135484 0.001588 0.000189 0 0.000884 0.010055 0.382608 0 7.80E-07 0.078285 0.004149 0.002565 0 0 0.01063 0.784794 0 0.008033 0 0.001708 0.00035 0 0 0.002424 0.042038 0 0.007797 0.003041 0.004998 0.000151 0 0.001021 0.006513 0.234762 0 0.056281 0.026732 0.001755 0.000604 0 0 0.003653 0.10134 8.30E-05 0.003086 0.023875 0.003158 0.000578 0 0 0.011134 0.177019 0.001879 0.029646 0.015819 0.001216 0.000205 0 0 0.006848 0.136462 0 1.66E-18 0.010116 0.004276 0.001344 0 0.003018 0.011222 0.644397 0 0.045659 0.038845

Wiley-Blackwell and Society for Applied Microbiology Page 85 of 848

Listeria monocytogenesBacteroidesBordetella vulgatus strain 4b strain bronchisepticaF2365-08korarchaeote ATCC 8482-01Deinococcus OPF1-KOR-30 RB50-30Xenorhabdus radioduransClostridium bovienii str. R1-30 strainHaloterrigena botulinum SS-2004-01 ThioalkalivibrioA2 turkmenica strain Kyoto-30 strain sp. HL-EbGR7-01 DSM 5511-08 0 0.005746 0.036055 0 0 0.007143 0 0.000844 0.105196 0 0.001259 0.007208 0 0 0.000274 0 0 0.019506 0 0.00108 0.001601 0 0.010183 0.003262 0 0 0.024903 0 0.002014 0.0029 0 0.029976 0.002209 0 0 0.038761 0 0.00275 0.008903 0 0 0.003006 0 0 0.014047 0 0.002513 0.007614 0 0 0.00497 0 0 0.065624 0 0.003253 0.007394 0 0 0.002645 0 0 0.090745 0 0.003733 7.62E-06 0 0 0.004937 0 0 0.073054 0 0.0004For0.001861 Peer0 Review0 0.003475 2.19E-05 Only 0 0.032784 0.001168 0.001688 0 0 0.069841 0.00372 0 0 0.053259 0 0.004534 0.011678 0 0.022013 0.002444 0 0 0.051826 0 0.001358 0 0 0 0.002266 0 0 0.023397 0 0.004961 0 0 0 0.006218 0.011937 0 0.090977 0.004956 0.000564 0 0 0 0.001216 0 7.26E-06 0.025425 0 0.001665 0.010404 0 0 0.001405 6.01E-15 0.000324 0.072215 0 0.000722 0.004531 0 0.001225 0.000617 0 5.46E-05 0.023278 0 0.003534 0.006074 2.93E-11 0.00097 0.005307 0.000495 0.000208 0.078718 0 0.002369 0.001799 0 0.002055 0.000544 0 0 0.005994 0 0.002699 0.009667 0 0 0.006886 0.020069 0 0.091025

Wiley-Blackwell and Society for Applied Microbiology Page 86 of 848

CenarchaeumCampylobacter symbiosumClostridium B-01 jejuni subsp.Rhizobium kluyveri jejuni strain leguminosarumLactococcus strain NBRC 81116-01 12016-08Agrobacterium lactis bv. subsp. viciaeActinobacillus cremoris str. vitis 3841-30 strainBurkholderia strain succinogenes S4-08 SK11-30Rhizobium pseudomallei strain sp. 130Z-01 NGR234-01 strain 1106a-01 0.846458 0.001155 7.39E-06 0.001704 0 0.023241 0.000775 0.000227 0.024895 0 0 0 0 0 0.025038 0.002371 0.00011 0.002844 4.31E-05 0.000262 0.000534 0.003925 0 0.03378 0.002224 0.000327 0.0057 0 0 0 0.017621 0 0.055471 0.007291 0.000112 0.011591 0 0.000824 0 0.00266 0 0.043725 0.00555 3.46E-06 0.005626 0.002081 0.001004 0 0 0 0.040835 0.008382 0.000536 0.006883 0.047699 0.000431 0.002805 0.002443 0 0.029536 0.005802 0 0.013326 0.017989 0.000123 0 0 0 0.045419 0 0.001162 0.00887 0 0.000342For0.003898 Peer0.006288 Review0 0.01441 0.003808 Only1.46E-08 0.005995 0.004097 2.95E-12 1.54E-05 3.39E-18 0 0.025082 0.003551 0.000104 0.00886 0.005244 0.000469 0 0.004528 0 0.029113 0.002003 0.000597 0.008388 0 2.24E-08 0 7.61E-05 0 0.012684 0.006347 0.000206 0.011757 0.004784 0 0 0.007853 0 0.054907 0.018556 0 0.010426 0.000787 1.90E-17 0 0.003734 0 0.002457 0.001132 0.000161 0.00901 0.09819 0 0 0.007691 0 0.067171 0.004996 0.000238 0.006724 0.000408 0.000497 0.000505 0.001425 0.002227 0.013653 0.00105 7.79E-06 0.006237 0.084384 0.000618 0 0.003869 0 0.038955 0.008545 0.001074 0.008704 5.69E-14 0.00024 0 0.000843 0 0.023067 0.000553 4.37E-05 0.003549 0 9.30E-14 0 0.016401 0 0.051708 0.004214 0.000546 0.011107

Wiley-Blackwell and Society for Applied Microbiology Page 87 of 848

Ehrlichia ruminantiumStreptococcus Buchnerastrain gordonii Gardel-30 aphidicolaSynechococcus str. Challis str. Shewanellasubstr. Sg sp. (Schizaphis CC9902-30V288-01Polynucleobacter sediminis graminum)-01 strainDesulfotomaculum HAW-EB3-01 sp. QLW-P1DMWA-1-01Thermus reducens thermophilusClostridium strain HB8-01botulinum MI-1-30 A strain ATCC 3502-01 0 0.00074 0 0 0.006708 0.01207 0 0.003206 0 0 0.000915 0.001837 0.214061 0.002159 0.003848 0 0 1.04E-05 0 0 0.001765 0.076528 0.002791 0.002014 0 4.99E-22 0 0 0 0.00417 0.005912 0.009155 0.008414 0 4.83E-26 0 0 0 0.005465 0.018755 0.00409 0.005447 0.0127 3.21E-06 0 0 0.001368 0.0093 0.309288 0.009489 0.008113 0 5.68E-20 0 0 1.60E-05 0.003482 0 0.011113 0.015713 0 0 0 0 0 0.009325 0.011613 0.011675 0.010888 0 8.06E-10 0 0.026284 For0 0.006862 Peer0.711951 0.003105Review0.009685 Only0 0 2.67E-05 0 0 0.004418 0.107154 0.007059 0.007915 0 2.09E-18 0 4.62E-08 0 0.004134 0.232752 0.007031 0.009606 0 0 0 0 0.000852 0.020421 0.07124 0.007345 0.009737 0 1.57E-06 2.00E-05 0 0 0.017013 0.026111 0.018528 0.010341 0 5.16E-07 0.000131 0 0 0.002973 18.46993 0.003039 0.007069 0.001648 0.003944 3.12E-05 0 0 0.021053 0.025366 0.003343 0.011616 0.016237 0.002456 0.00045 0 0.00046 0.007226 10.49064 0.002999 0.003972 0.012048 0.000691 0 0.005885 0 0 0.006385 0.005805 0.005789 0.003905 0 0 0 0 0.004833 0.045369 0.002403 0.000653 0 0.000255 0 0.012818 0 0.003676 0.02107 0.017425 0.007847 0 4.51E-18 0

Wiley-Blackwell and Society for Applied Microbiology Page 88 of 848

Rickettsia prowazekiiCandidatus strain ColwelliaAmoebophilus Madrid sp.Chlamydophila 34H-01E-01 asiaticusRickettsia strain pneumoniae 5a2-08 canadensisStaphylococcus CWL029-30 strainBacillus aureus McKiel-30 sp. Borrelia KSM-K16-08subsp. aureus burgdorferiBacillus strain subtilis str. Mu3-01 B31-08 subsp. subtilis str. BGSC 1A700-01 0 0.042429 0.072005 0 0 0 0.011204 0 0.001803 0.001101 0.019253 0.009192 0 0 0 0 0 0 0.003174 0.023205 0.022085 0 0 0 0.001627 0 1.85E-05 0 0.012485 0.06912 0 0 0 0 0 0 0.005331 0.019524 0.021508 0 0 0 0 0 1.34E-14 0.00101 0.005176 0.069418 0 0 0 3.28E-06 0 4.27E-05 0.008869 0.019103 0.045663 0 0 0 1.04E-06 0 7.85E-05 0 0.00104 0.039316 0 0 0 3.43E-09 0 0.00057 0.003041 0.011956For0.037009 Peer0 0.031588Review0 0.002661 Only 0 5.54E-06 0 0.01066 0.035919 0 0 0 0.003407 4.31E-09 2.96E-05 0 0.001708 0.032808 0 0 0 0.000587 0 2.38E-05 0.000721 4.71E-09 0.040262 0 0 0 0 0 6.95E-08 0.00072 0.038362 0.095981 0 0 0 0.00022 0 0.000357 0.002482 0.001023 0.010083 0 0 0 0 0 5.69E-05 0 0.015385 0.039219 0 0 0 0.001818 0 0.001818 0.0043 0.016163 0.009739 4.90E-13 0 0 0.001852 0 0 0.002988 0.015477 0.04289 0 0 0 0.003483 0 0.000654 0.001737 0.004112 0.034786 0 0 0 0 0 4.28E-09 0 0.01302 0.088465 0 0 0.000173 0 0 1.49E-16

Wiley-Blackwell and Society for Applied Microbiology Page 89 of 848

Legionella pneumophilairon-oxidizingStaphylococcus str. Lens-01Ruthia ES-1-01 lugdunensis magnificaVerrucomicrobiales strainstr. CmMethanosarcina HKU09-01-08 (Calyptogena str.Natronomonas PB90-1-08 magnifica)-08 acetivoransDichelobacter pharaonis str. C2A-08Staphylococcus nodosusstrain DSM str. 2160-01 aureusVCS1703A-08 subsp. aureus COL-01 0.01976 0.010006 0 1.503532 0.33938 0.007631 0.000675 0 0 0.001022 0.00481 0 1.378213 0.012325 0.006059 0 0 0 0.00197 0.007381 0 1.683183 0.00478 0 0 0.017932 0 0.003329 0.030098 0 1.194473 0.00067 0 0 0.009336 0 0.005192 0.01044 0 0.148857 0.00119 2.72E-05 0 0.012515 0 0.005373 0.017477 0 2.885873 0.023153 0 0 0.052743 0 0.005864 0.025688 0 3.995933 0.05196 9.00E-06 1.53E-06 0 0 0.008102 0.024431 0 4.711183 0.015621 0 2.57E-07 0.072964 0.000164 0.004354 0.008456For Peer0 0.843216 0.005751Review0 Only0 0.015172 0 0.003039 0.014719 9.10E-11 3.133218 0.006249 0.000287 0 0.040517 0 0.004648 0.021614 0 4.886585 0.003936 0.001008 1.63E-08 0.049436 0 0.007641 0.009538 0 0 0.008448 2.84E-05 0 7.61E-13 0 0.007882 0.038205 0 1.035209 0.007401 0.000279 0 0.075034 0 0.006479 0.006248 0 0.80818 0.011004 6.37E-05 4.91E-05 0.014579 0.000306 0.005835 0.034798 0 7.735271 0.130303 0.004895 0.001581 0.036003 0.000257 0.003844 0.004241 0 0.39124 0.045976 1.37E-05 0 0.021349 0 0.007189 0.045374 0.00057 4.562922 0.126942 0.0004 0 0.024715 6.85E-05 0.001307 0.003051 0 0.974287 0.003659 0.000455 4.78E-05 0.019404 0 0.004733 0.027663 0 1.960572 0.008456 0.000938 0 0.023823 0

Wiley-Blackwell and Society for Applied Microbiology Page 90 of 848

HelicobacterGluconobacter mustelae Atopobiumstrain oxydans 12198-01Helicobacter parvulum strain 621H-30 strainRhizobium pylori DSM strain 20469-08etliBurkholderia J99-01strain CIATAzoarcus sp. 652-30 PsJN-30 sp.Francisella BH72-30 tularensisAcidothermus var. palaearctica-08cellulolyticus strain 11B-01 0.000156 0 0 0 0.008755 1.12E-09 0.054697 0 0.032151 0 0.024351 0 0 0 0.04983 0 0 2.92E-05 2.52E-10 0.030347 0 0 0.000734 0.00758 0.011023 0 2.38E-05 0 0.033833 0 0 0.005311 0.00952 0.010335 0 7.10E-07 0 0.017291 0.005564 9.94E-08 0.002047 0.008384 0.037679 0 0.000792 0.000381 0.053711 0 0 0 0.003268 0 0.034965 0.000527 2.50E-05 0.000702 0 0 0.009362 0.000392 0.016617 0 0.001965 4.13E-10 0.002331 0.013127 0 0 0.057556 0 0 0.000165 0 0.037783For0.004287 Peer0 0.002691Review0.010788 0.007684 Only 0 0.001925 5.27E-10 0.004989 0 0 1.14E-05 0.000122 0.01598 0 0.002346 0.001594 0.030304 0 0 0.004965 0.000213 0.074891 0 0.000439 0.001211 0.038902 0 7.55E-10 0.000469 0.010241 0.010778 0 0.00019 0.00022 0.003595 0 0 0.005004 0.000273 0.0229 0 3.72E-14 0 1.78E-06 0 0.001392 0.004381 0.008645 0.011541 0 0.004132 7.28E-06 0.019026 0 0 0.003617 0.022532 0.02846 0.03108 0.000265 0.001427 0.006439 0.005671 0 0.006785 0.00722 0.00198 0 0.000271 1.74E-05 0.014324 0 0 0.010523 0.008986 0.020188 0 0.001813 1.56E-05 2.25E-06 0 0 0.007248 6.18E-05 0.036883 0 0 4.16E-08 0.008481 0.00202 0 0.005586 0.006778 0.014988 0 0.00029

Wiley-Blackwell and Society for Applied Microbiology Page 91 of 848

Listeria monocytogenesMeiothermusFlavobacteriaceae strain ruber HCC23-08 strainEscherichia DSM bacterium 1279-01 Methylobacteriumcoli O26:H11 3519-10-30Thermoanaerobacter strain radiotolerans 11368-01Methanococcus italicusstrainBdellovibrio maripaludis JCM strain 2831-01Methylococcus bacteriovorusAb9-01 strain C7-08 capsulatusstrain HD100-01 str. Bath-30 0 0.011276 0.002263 0 0.013342 0.011175 0 0.014613 0.02447 0 0 0.075099 8.42E-05 0.000738 0 0 0.001098 0.222001 0 4.44E-15 0.345419 0 0.002291 0 0 0.000986 0.082557 0 0 0 0 0.002757 0 0 0.000272 0.172539 0.003526 4.81E-05 0.303079 0 0.001063 0.000144 0 0.001368 0.072579 0.007377 0.000179 0.141415 0 0.001413 0.000131 0.004646 0.001058 0.05746 0 0.003115 0.257335 0 0.005441 0.000339 0 0.004536 0.105276 0.003607 0.002424 0.178206 0 0.003399 0.001115 0 0.000602 0.150048 0 0.001365For0.138649 Peer0 0.002536Review0.000106 Only0 0.001172 0.114633 0 0.000276 0.167726 0 0.001385 7.70E-05 0 0.000835 0.029578 0 1.01E-06 0.096392 0 0.001135 0.000191 0 0.006003 0.062705 0 1.45E-06 0 0 0.004349 0.000132 0 0.001281 0.041919 0 0.000332 0.279184 0.001376 0.001075 2.16E-14 0.005377 0.000388 0.031322 0 5.76E-05 0.058575 3.33E-05 0.002425 0.001055 0 0.003154 0.030183 0.002921 0.0018 0.319625 0.00114 0.001852 0.000483 0 0.009308 0.452613 0 1.29E-05 0.150857 0 0.001296 1.55E-09 0 0.000437 0.037711 0.000281 0.003878 0.310118 0.000233 0.001714 0.000964 0 0.001887 0.141574 0 0 0.145052 0 0.000852 0.000174 0 0.001446 0.001539 0 0.000288 0.243684 0 0.002646 1.62E-05 0 0.001017 0.111895

Wiley-Blackwell and Society for Applied Microbiology Page 92 of 848

Escherichia Exiguobacteriumcoli O111:H-Desulfovibrio strain sp. 11128-08 AT1b-30Thermosipho desulfuricansShewanella melanesiensis subsp.Xanthomonas halifaxensisdesulfuricans strainMethanoculleus BI429-01 strain albilineansstrain HAW-EB4-01 G20-01Geobacter var. marisnigri paspali-08 sp.Bacillus FRC-32-01 strain cereus JR1-01 strain ATCC 10987-08 0 0 0.004009 0 0.005548 0.029423 0.005402 0.011779 0 0 0 7.95E-06 0 0.000882 0.008964 0 2.06E-06 9.64E-05 0.003053 0 0.000221 7.98E-05 0.003724 0.010947 0 4.41E-06 0 0.005739 0 2.44E-12 0 0.005089 0.01391 0 0.000363 0 0.003384 0 0.000257 2.90E-07 0.00227 0.002069 0 0.000129 0 0 0 0.000316 0.00027 0.009508 0.008921 0 0.000331 0 0 0.03312 0.002249 2.11E-06 0.006655 0.003889 9.02E-07 0.00298 8.21E-05 0 0 0.002477 1.91E-05 0.007148 0.017837 0.000164 0.002082 0 0.002242 For0 0.000111 Peer0 0.004154Review0.004487 Only0 0.00049 2.38E-09 0 0 0.000369 1.13E-08 0.005534 0.004168 0 0.000496 0 0 0 0.000905 7.15E-05 0.005943 0.009161 4.56E-06 0.001634 0 0 0 0.001276 0 0.005341 0.002376 0 7.98E-05 0 0.005295 0 0.000815 2.08E-11 0.013967 0.022858 0 0.000336 0 0.000792 0.00048 0.000236 0.000643 0.001818 0.005501 0 0.000352 0 0 0 0.00044 3.25E-05 0.008254 0.007007 0.000104 0.003039 0 0 3.58E-12 7.71E-07 0.000646 0.001795 0.001804 0 5.25E-05 0 0 0 0.003088 1.45E-06 0.007583 0.020362 0.000992 0.005221 0 0.001774 0 0.001158 6.00E-09 0.001616 0.012187 0 1.99E-06 0 0 0 0.000408 2.09E-08 0.013553 0.016987 0 0.000475 7.81E-05

Wiley-Blackwell and Society for Applied Microbiology Page 93 of 848

ProchlorococcusBacillus marinus thuringiensisSynechococcus str. NATL1A-30 strainComamonas sp. Al CC9311-08Hakam-08Synechococcus testosteroniSulfurihydrogenibium strain sp. strain CNB-2-01Polaromonas JA-2-3B'a(2-13)-30 azorenseAcinetobacter sp. JS666-01 strainConexibacter sp. Az-Fu1-08 ADP1-01 woesei strain DSM 14684-30 0.024152 0 0 0.001015 0.001471 0.020242 0.026414 0.001979 0 0 0 0.01723 0.000508 0.223325 0 0.00151 0 0 0 0 5.046316 0.002186 0.013409 0 0.002853 0.007832 0 0 0 0 0.003251 0.03246 0 0.003228 0.01404 0 0.015754 0 0.490508 0.002025 0.006018 0 0.002783 0.005077 7.83E-05 0 0 0 0.003021 0.25732 0 0.00606 0.014142 0 0.057057 4.75E-05 0.002714 0.003148 0.104836 0.012409 0.006147 0.007542 0.005582 0 0 0 0.002727 0.027615 0 0.004304 0.009358 0.056609 0.01643 For0 4.329937 Peer0.006112 0.032655Review0.003562 0.003299 Only0.011179 0.006597 1.03E-08 0.001792 0.002736 0.004131 0.15185 0.006122 0.000784 0.00945 0 0.005065 0.000477 0.000495 0.002292 0.229866 0.018009 0.003601 0.013022 0 0.010458 0 2.837149 0.003418 0.004331 0 0.002466 0.01528 0 0 0 8.48E-05 0.005551 0.087968 0 0.001331 0.019034 0 0 0 9.956869 0.001691 0.065658 0 0.00248 0.00401 0.000247 0 0 0.002394 0.003624 0.014821 0.010162 0.004946 0.008471 0.027257 0.038335 0 5.085718 0.002934 0.03274 0.010392 0.002973 0.003168 0.005519 0.021622 0.001413 0.006195 0.003922 0.014659 0.01145 0.006379 0.010226 0.010177 0 0 2.04E-07 0.001819 0.071295 0 0.001559 0.004999 0 0.015041 0 0.004519 0.005534 0.084858 0.008187 0.004337 0.021399 0

Wiley-Blackwell and Society for Applied Microbiology Page 94 of 848

[Mesorhizobium]Lactobacillus sp. BNC1-30Archaeoglobus brevis strainMethanohalophilus ATCCprofundus 367-01Sulcia strain muelleri mahii DSMGeobacter strainSMDSEM-305631-01 DSM uraniumreducensAeropyrum 5219-01Macrococcus pernix Rf4-01 strainBurkholderia caseolyticusK1-08 pseudomallei strain JCSC5402-01 strain MSHR346-01 0.024872 0 0.004822 0.016882 1.617794 0.017333 0 0.00036 0.001015 0.003659 0 0 0 1.477839 5.38E-06 0 4.90E-05 0.00026 0.046648 0 0 3.67E-05 0.057144 1.78E-05 0 0.000229 0.000325 0.116627 0 0 0 0 0.001779 0 0 0.001959 0.04934 0 0 0 0.165432 1.92E-05 0 0 0 0 0 0 0.000149 0 0.000173 0 0.002444 0.00211 0.03843 0 6.76E-06 0.000336 0.333881 0.00144 2.88E-17 0.000636 0 0.064244 0 0.000398 1.33E-05 0 0.000929 0 0.000145 0 0.016775 For0 Peer0 0.000249 0.547298Review0.000131 Only0 7.30E-05 0.001354 7.05E-10 0 1.34E-05 0.000178 1.277382 0.000166 0 0.002409 0.001002 3.97E-09 0.000307 0 0.000147 2.380967 0.002449 0 0 0.001862 0.06828 0 0 0.001285 0 0.001451 0 0.000144 0.000682 0.00262 2.80E-06 0 0.000354 0.720303 0.00242 0 0 0 0.009203 0 0.000589 7.19E-05 0.702069 0.000122 0.001998 6.20E-05 0.000667 0.069951 0 0.002934 0.002676 0.052009 0.004481 6.55E-11 3.80E-05 0 0.009361 0 0 1.75E-06 0.133759 0.00054 7.96E-06 0 0.001455 0.048866 1.53E-06 1.83E-10 0.003927 0.2445 0.002208 0.005151 0.000349 0.002385 0.029805 0 0 2.50E-05 0 7.51E-07 0 2.75E-07 0.000163 0.02072 0.000418 0 0.000242 0.408725 0.002015 0 4.31E-19 0.001268

Wiley-Blackwell and Society for Applied Microbiology Page 95 of 848

LactobacillusListeria casei strainmonocytogenesPelodictyon BL23-08 Conexibacter luteolum strain Clip80459-08 DSMStreptococcus woesei 273-30 strainThermoplasma suis DSM strain 14684-01Synechococcus BM407-01 volcaniumRhizobium strainsp. strain GSS1-08 radiobacterMethylovorus JA-2-3B'a(2-13)-08 str. sp. C58 SIP3-4-01 (U. Washington)-30 0 0 0.095365 0.023821 0 0.000675 0.020642 0.009523 0.033575 0 0.023912 0.169028 1.01E-09 0 0 0.03638 0.027889 0.026844 0 0 0.00463 2.64E-08 0 0 0.00709 0.050395 0.030095 0 0 8.41E-10 3.30E-05 0 0 0.002961 0.1715 0.05047 0 0 0.00066 0.00043 0 0 0.010571 0.031266 0.034763 0 0 0.025089 1.87E-07 0 0 0.022949 0.01262 0.075635 0 0 0.00224 0.001259 0 0 0.010488 0.039959 0.101818 0 0.000251 0 0.000785 0 0 0.050603 0.012105 0.060639 0 For0 8.67E-05 Peer3.22E-05 Review0 0 0.015665 Only0.015599 0.071208 0 0 0.003213 3.36E-05 0 0 0.018213 0.023486 0.061324 0 0 0.00034 9.00E-06 0 0 0.005316 0.055278 0.047385 0 0 0.001108 9.55E-05 0 0 0.024682 0.002595 0.037666 0 0 0 0.000163 0.001799 0 0.024022 0.056685 0.042379 2.34E-06 0 0 0.000594 0 0.000759 0.011475 0.021379 0.050933 0 0 0.050157 0.001285 0 0 0.000264 0.035517 0.083207 0 0.003334 0 0.000213 0 0.000155 0.004424 0.025926 0.033534 0 2.47E-08 0.043128 0.002024 0 0.003083 0.004617 0.038337 0.086802 0 0 0.043955 9.63E-05 0.000918 0 0 0.048111 0.023944 0 0 0.00146 6.01E-05 0 0 0.018929 0.050391 0.054053

Wiley-Blackwell and Society for Applied Microbiology Page 96 of 848

Escherichia iron-oxidizingcoli strain ATCCBacillus lithotroph 8739-30 medusa-01Dyadobacter ES-1-08 Candidatus fermentans MycobacteriumAmoebophilus strain DSMMethanocaldococcus 18053-30 asiaticus ulceransFrankia strainstrain sp. 5a2-30Agy99-01 vulcanius KribbellaEAN1pec-30 strainflavida M7-08 strain DSM 17836-01 0 0.067415 0.008251 0.063902 1.10E-08 0.000438 0.009428 0.000416 0.007427 0 0.054503 0 0.034437 0.217229 0 0 0 1.85E-05 0 0.029706 0 0.024682 0.059434 0 0 0 0.000174 0 0.048581 0 0.024509 0.000248 0 0 5.81E-06 2.44E-06 0 0.018139 0 0.021495 0.01892 0.00032 0 0.000261 0.000365 0 0.062781 0.002426 0.007678 0.131808 0.00019 0 0 0.000204 0 0.041313 0 0.120704 0.032555 8.87E-05 8.64E-18 0.010242 5.35E-05 0 0.092329 0 1.44E-06 0 1.17E-05 0 0.05492 0.000504 0 0.014398For Peer0 0.019428 Review0.0533 1.01E-05 Only0 0 0.000185 0 0.091179 0 0.033979 0 0.000294 0 0.000102 2.96E-05 0 0.10906 0 0.009027 0 5.31E-05 0 0 5.67E-05 0 0.032067 0 0.014732 2.59E-09 3.95E-05 0 0 0.000256 0 0.130747 0 0.098896 0.02307 2.18E-06 0 0.011109 5.29E-06 0 0.011052 0 0.002397 0.041137 1.44E-06 0 0.000581 0.001939 0 0.087842 0 0.097468 0.091669 0 0 4.07E-06 0.00124 0.002349 0.007683 0 0.049004 0.013443 0.000122 0.000671 0.002633 0.000437 0 0.043186 0 0.056219 0.094955 0 0.002587 0.004793 0.00077 0 0.019674 0 0.064116 0 0 0 0 2.43E-08 0 0.121601 0 0.063688 0.070429 0.000687 0.0008 0.005052 1.44E-07

Wiley-Blackwell and Society for Applied Microbiology Page 97 of 848

TrichodesmiumThermotoga sp. IMS101-08Erwinia maritima amylovora strainDenitrovibrio MSB8-08 strainSynechocystis acetiphilusATCC 49946-08Helicobacter strainsp.PCC6803-01 DSMDenitrovibrio pylori 12809-08 strainWolbachia acetiphilus G27-30 sp.Shewanella strain wRi-01 DSM sp. 12809-01 W3-18-1-01 0.007901 4.82E-05 0 0.049911 0.008698 0 0.015594 0.005784 0.008853 0.021943 0 0 0 0.005067 0 2.58E-05 0.000276 0.000157 0.02044 0 0 0.007857 0.001601 0 0.000303 0.007274 0.000772 0.020023 0.00073 0 5.91E-06 2.84E-05 0 0.000211 0.001241 0.00118 0.018105 0 0.008655 0.007384 0.000662 0 0.000131 0.006226 0.003821 0.004956 0 0 0.006345 0.00223 0 0.001171 0.003701 0.005257 0.01565 0 0 0.019358 0.001635 0 0.004525 0.002615 0.002527 0.013809 0 0 6.93E-10 0.003386 0 0.001972 0.002778 0 0.022362 For0 Peer0 4.64E-05 0.001045Review0 0.000465 Only0.004593 0.002538 0.010289 0.00233 0 0.007922 0.004183 0 6.36E-05 0.002011 0 0.005951 0 0 0.003514 0.004879 0 0.0012 0.01155 0.005848 0.05326 0 0.012387 0.000377 0.000756 0 0.000827 0.002886 0 0.016319 0 0 0.009982 0.001867 0 0.000348 0.007594 0.010303 0.018018 0 0.002025 0.00267 0.00253 0 0.000212 0.009133 0.003302 0.016306 0 0 0.040157 0.003543 0 0.00393 0.004076 0 0.018187 0 0 0.007105 0.000379 0 0.000848 0.004352 0.001422 0.005454 0.006441 0 0.040016 0.001879 0.002145 0.00606 0.005934 0.003798 0.02029 0 0 2.87E-05 0.00056 0 0.000267 0.005001 0.003459 0.011191 0 0 0.003581 0.000384 0 0.001997 0.001544 0.005412

Wiley-Blackwell and Society for Applied Microbiology Page 98 of 848

Borrelia hermsiiEscherichia strain bacteriumDAH-08coli O127:H6 Ellin345-08Ralstonia strain E2348/69-08 pickettiiEscherichia strain Methanothermobactercoli 12D-01 strain IAI1-30StaphylococcusThermotogales thermautotrophicus aureusMycoplasma subsp. bacterium aureus str. gallisepticum deltaH-01 strainTBF 19.5.1-01 MRSA252-01 strain R(low)-01 0 0 0.11095 0.000835 0 0.000642 0 0 0 0 0 0.000942 0.001228 0 0 0 4.02E-18 0 0 0 0.002861 0.000484 0 0 0 2.14E-14 0 0 0.000222 0.000393 0.005741 0 0 0 0 0 0 0 0.000806 0.002273 8.07E-07 0 0 1.98E-05 0 0 0 0.003792 0.001847 0 5.37E-05 0 1.76E-11 0 0 0 0.009775 0.005015 0 3.46E-12 0.000255 0 0 0 0 0.000324 0.004078 0 0.001493 0 3.15E-12 0 0 For0 0.001913 Peer0.001959 Review0 5.60E-07 Only0 1.41E-22 0 0 0.001309 0.000168 0.00242 0 8.56E-15 0 9.38E-08 0 0 0.001855 0.000155 0.001864 0 0.001669 0 0.000146 0 0 7.69E-05 0 0.001834 0 0 0 0.00031 0 0 0.00575 0.001051 0.004021 0.004526 0 5.85E-11 7.83E-23 0 0 0.00284 0.003558 0.001238 0 6.62E-05 0 6.43E-12 0 0 0 0.035473 0.001521 0 0.000829 0 0.001879 0 0 0.003332 0.002961 0.000802 0 0.001019 0 0.000978 0 0.005008 0 0.023153 0.004512 0 2.69E-06 0.000433 0.001931 0.003248 0 0.001127 0.0009 0.000733 0 0 0 1.59E-09 0 0 0 0.001226 0.007847 0 7.73E-06 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 99 of 848

Bacillus anthracisFrankia str. alni Sterne-01Bdellovibrio strain ACN14a-08Clostridium bacteriovorusClostridium botulinum strain HD100-30 Escherichia E3botulinum strain Alaska YersiniacoliA3 strain strain E43-08 pestis Loch SE11-30Aquifex strainMaree-30 aeolicus Z176003-01Corynebacterium str. VF5-01 efficiens strain YS-314-01 0 0.008209 0.070912 0.00437 0 0 0 0.007084 0.000892 0 0.000823 0 0 0 0.369078 0 1.31E-09 0 0 0.001557 0 0 0 0.012421 0.000307 0 3.71E-05 0 0.00217 0 0 0 0.095524 0 0 0.000962 0 0.000139 6.28E-06 0 0 0 0 3.24E-05 0.000193 9.64E-05 4.43E-06 0.151513 0 0 0 0 5.76E-07 0.001851 0 0.000763 0.000296 5.53E-08 0 0.061704 0 0.000318 0.000312 0 0.004137 3.02E-10 0 0 0 0 0.002994 0.000319 0 3.59E-05For0.006817 Peer0 6.47E-08Review0 Only0 9.33E-07 1.00E-05 0 0.00084 0.033104 0 0.005695 0.174292 0 0 0.001187 2.12E-06 0.000293 0.005418 0.002953 0 0.391396 0 1.89E-06 0.000101 0 0 0.013027 0 0 0.055509 0 0 1.32E-05 0 0.000468 2.74E-24 0 0 0.073838 0 6.00E-05 0 0 3.29E-05 2.57E-07 0 0 0.030679 0 0.001913 0.000185 0 0.005979 0.076913 0.00221 5.83E-05 0.070131 0 9.88E-05 0.00035 0 0.001053 1.04E-11 0.000316 0 0.025731 0 0 0.000212 0 0.003894 0.022803 0 0 0.034473 0 0.0038 0.000132 0 0.000267 0 0 0 0 0 2.95E-09 2.32E-05 0 0.00029 1.69E-14 0.000255 8.02E-11 0.095734 0 2.66E-13 0.000147

Wiley-Blackwell and Society for Applied Microbiology Page 100 of 848

SulfurihydrogenibiumPolaromonas sp.Vibrio naphthalenivorans YO3AOP1-30 parahaemolyticusStreptococcus strainLeptospirillum str. pneumoniae CJ2-30 RIMDThermus 2210633-01 ferrooxidans strain thermophilus ThiomicrospiraP1031-30 ATCC Methanococcus53993-08 HB8-08 denitrificansBacillus vannielii ATCC cytotoxis 33889-01 strain NVH SB-30 391-98-30 0 0.129636 0.006603 0 0.016499 0.007759 0.000905 0 0 0 0.000748 0.002538 0 0 0 8.50E-06 0 0 0 0.015176 0.002645 0.027585 0.002334 0 3.30E-05 0 0.001847 0 0.000551 0.004354 0 0.003195 0.003326 0.003753 0.077472 0 0 0.008665 0.002997 0 0.002059 0.001282 0.004198 0 0 0 0.069884 0.002694 0 0 0.0039 0.005446 0.042857 0 0.000108 0.000369 0.002668 0 0 3.72E-06 0.001725 0 0.000215 0 0 0.011423 0 0.01278 0 0.008758 0 0 0.003098 0.002107For0.002294 Peer0 Review0 0.003022 0.000124 Only 0 0 0 0.002523 0.003763 0 0 0 0.001318 0 0 0 0.002204 0.002732 0 0.020249 8.25E-17 0.003696 0.127805 0 0 0.016024 0.003099 0 0 0 0.000256 0 0 0 0.044254 0.020285 0 0 0.003035 0.0091 0.058009 0 0.005381 0.001152 0.001968 0 0.004205 1.27E-08 0.000275 0 0 0.013948 0.002818 0.005813 0 0.027066 8.39E-05 0.007981 0 0 9.35E-08 0.000492 0.002146 0.006518 0.004004 0.004002 0.002119 0 0.008851 9.84E-05 0.012473 0.00554 0 0.021228 0.003804 0.003936 0.001274 0.005634 0 0.008296 0.001471 0 0 0 0.002272 0 0 0 0.002194 0.018496 0 0 0.000375 0.001196 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 101 of 848

Frankia alniThermoanaerobacter strain ACN14a-01Listeria monocytogenes tengcongensisStreptococcusBurkholderia strain strain gallolyticus EGD-e-08 MB4-30Prochlorococcus sp. strain STM815-08 UCN34-30Brucella sp. suisMIT9215-30Sinorhizobium str. 1330-30Rhodobacter medicae WSM419-30 capsulatus strain SB1003-01 0.005222 0 0.005854 0 0.01195 0.011111 0 0 0.008779 0.000145 0 0 0 0.007453 0 0 0 0.006852 0.000333 0 0 0 0.004229 0 0 0.010211 0.016174 3.46E-11 0 0 0 0.007517 0 0 0.012142 0.110928 2.85E-05 9.33E-05 0 0 0.001985 0 0 0.022026 0.046572 2.19E-05 0 0 0.002732 0.006236 0 0 0.009554 0.036486 0.000381 0 0 0 6.11E-05 0 0 0.022999 0.04156 0.000163 0 0.000939 0 0.003856 0 0 0.012615 0.03248 4.53E-05 For0 Peer0 0 0.001509Review0 Only0 0.005551 0.048931 1.33E-09 0 0.000995 0.03266 0.007376 0 0 0.004695 0.025645 3.04E-05 0 0 0 0.006897 0.002851 0 0.049584 0.031215 0.000274 0 0 0 0.007591 0 0.053365 0.003722 0.063641 2.92E-13 0 0 0 0.012443 0 0 0.013947 0.103775 0.000855 0 0 0 0.001834 0.006332 0 0.003982 0.040201 1.55E-07 0.000515 0 0 0.006361 0.023714 0 0.033484 0.030344 0.000733 0.000714 0 0 0.00482 0.05664 0 0.001178 0.025676 0.000495 0.004136 0.000287 0 0.009113 0 0 0.022953 0.027718 2.52E-19 0 0 0 0.002676 0.006473 0 0.033769 0.036158 1.41E-05 0 0 0 0.001196 0 0 0.009506 0.117032

Wiley-Blackwell and Society for Applied Microbiology Page 102 of 848

Carsonella-Pv-01Prevotella ruminicolaXylella fastidiosa strainEscherichia 23-01str. Temecula1-08 Azospirillumcoli strain W3110-01Mycobacterium sp. B510-30Synechococcus avium Wautersiasubsp. sp. paratuberculosisWH7803-08 eutrophaLactobacillus H16-30 fermentumstrain K-10-01 strain IFO 3956-08 0 0 0 0 0.054732 4.80E-05 0.031723 0.031871 0.014346 0 6.96E-06 0.021717 0 0.025767 0 0.009633 0.002729 0.014149 0 0.000295 0.007664 0 0.012712 9.07E-05 0.064044 0.001096 2.39E-06 0 0.002311 0.008217 0 0.038386 2.78E-13 0.008343 0.01051 0.003531 0 0.000454 0.001478 0 0.009691 0 0.004443 0.013364 0 0.003394 0.002543 0 0 0 0.000183 0.007001 0.008345 0 0.020005 0.000416 0 0 0.012209 0.000407 0.016463 0.030506 0 0 0.000493 0.010643 0 0.000689 5.61E-05 0.010334 6.47E-14 0 0 0.000755For Peer0 0 0.020776Review0 0.102425 Only0.004426 0 0.007655 0.000656 0 0 0.010011 5.29E-05 0.010154 0.017425 0 0.039694 0.003027 0 0 0.014681 3.63E-05 0.006386 0.008287 0 0 0.000485 0 0 7.94E-05 0.000142 0.019514 0.000294 0 0.019915 0.002148 0.021546 0 0.008968 0.000675 0.001429 0.025073 0.00067 0 0.000197 0 0 0.024294 0.000384 0.386792 0.000737 0 0 1.82E-06 0 0 0.022216 0 0 0.038788 0.004022 0 0.001306 0.009109 0 0.019567 1.73E-07 0.25454 0.001834 0.00067 0 0.002139 0.003148 0.000502 0.019436 0.000189 0.00053 0.009341 0 0.028551 0.000977 0.00371 0 1.12E-18 0 1.37E-07 0.00828 0 0 0.000167 0 0 0.011215 4.27E-05 0.001264 0.007755 0

Wiley-Blackwell and Society for Applied Microbiology Page 103 of 848

ActinobacillusRhodopseudomonas pleuropneumoniaeBorrelia recurrentis palustris Bartonellastrain L20-08 strain strain henselaeFusobacterium BisB5-08 A1-01 strainFerroglobus nucleatumHouston-1-30Rhodobacter placidus subsp. strain nucleatumVibrio sphaeroides DSM fischeri 10642-01 str.Mesoplasma strainATCCstrain 25586-08 ES114-01ATCC florum 17025-01 strain L1-08 0 0.051353 0 0.22241 0.009058 0.002384 0.010622 0.000739 0 0 0.001646 0 0.868083 0 0 0.003775 0.001467 0 0.006921 0.01646 0 0.031711 0 0 0.010098 0.002906 8.13E-06 0.011975 0.008472 0 0.069007 4.42E-09 0 0.083233 0.005469 0 0 0.007668 0 0.025016 1.87E-05 0 0.039325 0.00431 0 0 0.01177 0 1.616464 0.009115 0 0.022353 0.006057 0 0 0.014646 0 0.311274 0.000269 1.14E-12 0.03036 0.006095 0 0 0.00927 0 2.426207 0 0.001009 0.027947 0.001565 0 0 0.010426For Peer0 0.046385 Review0 0 0.033825 Only0.002321 0 0.016052 0.00491 0 0.48201 0 1.36E-05 0.02189 0.004338 0 0 0.002977 0 0.759938 2.36E-06 0.00129 0.02184 0.004365 0 0 0.002903 0 0.127161 0 0 0.063778 0.004943 0 0.02782 0.008438 0 0.35106 0.001564 0 0.089979 0.004477 0 0 0.002967 0.000326 0.206623 0 0.000733 0.031783 0.00238 0 0 0.029529 7.51E-09 0.263775 5.04E-05 0.001262 0.023563 0.005584 0 0 0.00818 0 0.131033 0 0 0.021497 3.53E-06 0 0 0.019927 9.20E-05 0.061853 0.000675 0.000362 0.017427 0.006159 0 0 0.004067 0 0.062045 0 0 0.025608 0.00117 1.83E-07 0.022666 0.013923 2.61E-09 0.542353 0 0 0.086739 0.005023 0

Wiley-Blackwell and Society for Applied Microbiology Page 104 of 848

DesulfatibacillumBurkholderia alkenivoransAnaplasma sp. STM815-01 strain Herminiimonasphagocytophilum AK-01-30Rhizobium arsenicoxydans str. HZ-30etliCoprothermobacter strain Muller CIATRhizobium 652-08 et al. proteolyticus 2006-30radiobacterGeobacter metallireducens Parabacteroides DSMstr. C58 5265-01 (U. Washington)-01 straindistasonis GS-15-30 strain ATCC 8503-01 0.001089 0.003099 0 0.452083 0.019279 3.04E-11 0.01154 0.025975 0.003828 0 0.000998 0.278149 0 0.010752 0 0.006467 0 0.001619 0.000279 0.001394 0.00836 0.024613 0.00758 0 0.005027 2.38E-06 0.000754 0 0.001208 0.021837 0.014115 0.012003 0 0.022622 0 0.00393 2.78E-08 0.001532 0.031144 0.027865 0.006457 0 0.006381 0.00053 0.0025 0 0.00177 0.264814 0.000406 0.017093 0 0.015341 0 0.00245 0.01825 0.006466 0 0.06076 0.014511 8.70E-18 0.016794 0.064999 0.002767 3.39E-13 0.002924 9.29E-11 2.34E-16 0.030925 1.34E-16 0.019879 0 0.004764 0.001206 0.003144For0.026827 Peer0.039516 0.005135Review0 0.010623 Only2.88E-05 0.002009 0 0.002281 0.083689 0.056291 0.007813 7.17E-17 0.013172 7.07E-08 0.007572 0.033731 0.00301 0.149414 0 0.018392 0 0.009323 0.013127 0.006018 5.16E-05 0.00134 0 0.021924 0.009552 0 0.011545 2.85E-05 0.004899 0 0.00513 0.067817 0.015747 0.024937 0 0.014905 0 0.008267 5.18E-07 0.002834 0.037719 0.036734 0.003624 0 0.008275 6.63E-05 0.002113 0.049079 0.003759 0 0.047217 0.011653 0.000342 0.012862 0.061686 0.001042 8.96E-06 0.00205 0 0.05879 0.00497 0 0.009483 0.000886 0.000882 0.023795 0.001842 0.015352 0.018344 0.018699 0 0.011894 0.05019 0.004295 0 0.000965 0 0.000113 0.008608 0 0.004246 0.025038 0.000711 0.010016 0.002158 0 0.028238 0.012853 0 0.023815 0 0.005074

Wiley-Blackwell and Society for Applied Microbiology Page 105 of 848

HalothiobacillusPseudomonas neapolitanusListeria entomophila strainmonocytogenesListeria c2-01 strain monocytogenes StaphylococcusL48-30 strain EGD-e-01Salmonella strain aureus 08-5578-01 Leptospira entericastrain RF122-08 subsp. biflexaListeria enterica serovar monocytogenesYersinia serovar Patoc enterocolitica strainHeidelberg strain Paris-08 4b str. F2365-01subsp. SL476-30 enterocolitica strain 8081-01 0.038656 0.010506 0 0 0 0 0 2.85E-07 0.001208 0.005511 0.066581 0 2.00E-06 0 0.082138 8.37E-06 0 0.00029 0.010022 0.020097 0 0 0 0 0 0.000105 0.000356 0.009559 0.109471 0 0 0.00196 0 0.000239 0 0.001304 0.010703 0.018586 0.00011 0 0 0.006263 0.000464 0.000113 0.0014 0.017365 0.111333 0.000155 0 0 0 0.006855 0 0.004232 0.03571 0.013773 3.59E-05 1.46E-05 0 0 0.009245 0 0.002161 0.033328 0.132096 0.000191 0 0 0 0 0 0.000871 0.014766 0.032887For Peer0 0 Review0 0 Only0 0 0.00099 0.012965 0.017709 0 0 0 0 0 0 0.001978 0.025455 0.086597 0 0.00014 0 0.033524 0 0 0.001924 0.012778 0.04744 0 0 0 0 0 0.000378 0.00271 0.04232 0.043019 0 0 0 0 0 0 0.004751 0.014773 0.004432 0 0 0 0 0 0 0 0.01907 0.03424 0 0 0 0 0 0 0.002734 0.00846 0.033431 0 0 0 0 0.003283 0 0.000379 0.022635 0.018643 0 0 0 0 0 0 0.002484 0.002981 0.062404 0 0 0 0 7.11E-05 0 0.000864 0.023937 0.051663 0.00021 0 0 0 0.005732 0 0.006019

Wiley-Blackwell and Society for Applied Microbiology Page 106 of 848

Shigella flexneriStreptococcus 5 strainRickettsia 8401-01 thermophilus canadensisPelagibacter strain strainStreptococcus LMG ubique McKiel-01 18311-08 HTCC1062-30Magnetospirillum pyogenesBrucella str. MGAS315-01 sp. melitensis AMB-1-30Streptococcus str.Dickeya ATCC suis 23456-08 strain dadantii 05ZYH33-08 strain Ech586-01 0 0 0 3.879619 0 0.046735 0 0 0.001019 0 0 0.000532 4.508922 0 0.132775 0.011917 0.016671 0 0 0.00272 0.002323 39.95348 5.30E-08 0.078048 0 0 0.000281 0.000179 0 9.98E-06 11.4056 0 0.023573 0.006703 0 0.001556 0 0 0.001613 28.7571 0 0.018103 0 0 0.001168 2.39E-05 0 0 6.679618 0 0.002005 0 0 0.001815 0 0 0.005492 34.0448 0 0.044625 0.014127 0 0 0 0 0 1.856312 0 0 0.006277 0 0.002272 0 For0 0.001155 Peer37.29982 Review0 0.014816 Only0 0 0.001157 0 0 0.002444 23.59112 0 0.000554 0 0 0.00139 0 0 0.006841 9.676193 0.000598 0.044263 0 0 0.001775 0 0 0.000885 8.214119 0 0.017451 0.007703 0 0.001735 0 0 0 18.5682 0 0.040176 0 0 0.003691 0 0 0.004119 10.73412 0 0.011455 0 0 0.001839 0 0 0.002858 16.24989 0 0.062681 0 0 0.002894 0 0 0.000759 18.26887 0 0.024922 0.003244 0 0 0 0 0.00188 32.85269 0 0.108305 0 0 0.00125 0 0 2.83E-06 34.25909 0 0.000137 0.009532 0 0.000335 0 0 0 31.55344 0 0.02211 0 0 0.002011

Wiley-Blackwell and Society for Applied Microbiology Page 107 of 848

Wautersia taiwanensisNitrosococcusStaphylococcus (Chen oceani et al. strainEscherichia 2001) haemolyticus ATCC Vaneechoutte 19707-01 Shigellacoli strain strain dysenteriae UTI89-30etBacteroides JCSC1435-01al. 2004-30 strainGeobacter thetaiotaomicron Sd197-08 lovleyiExiguobacterium strain strainSalmonella SZ-08 VPI-5482-01 sp. AT1b-08 enterica subsp. enterica serovar Gallinarum strain 287/91-30 0.0016 0.03866 0 0 0 0.003058 0.072201 0 0 0.008922 0.007221 0 0 0 0.001426 0.008723 0 0 0.001474 0.010393 1.77E-05 0 0.000621 0.000536 0.004718 0 0 0.006185 0.018445 0 0 0 0.001821 4.86E-07 6.91E-05 0 0.009965 0.008016 0 0 0 0.001431 0.000401 0.002851 0.004026 0.005448 0.02048 0.000214 0 0.003154 0.001072 0.008539 0.006238 0 0.023112 0.029173 0 0 5.59E-05 0.002159 0.019758 0.001778 0 0 0.025406 0 0 0 0.001905 0.003478 0 0 0.006793 0.011764For Peer0 0 Review0 0.000709 0.002591 Only 0 0.00966 0.012246 0.019106 3.04E-08 0 0 0.001605 0.002949 0.000168 0 0.005144 0.015879 1.06E-05 0 0 0.002648 0.003224 0 0 6.39E-05 0.006969 0.000193 0 0.000127 0.001505 0.011382 0 0 0.006882 0.031427 2.78E-05 0 0.004799 0.001632 0.008637 0 0 0.004146 0.009144 0 0.010713 0 0.000147 0.003318 0 0 0.02518 0.023796 0.001984 0 0 0.001008 0.021245 0.0046 0 0.002619 0.008364 0 0 0 0.00046 0.002421 0 0.005909 0.013704 0.026164 0.000251 1.97E-08 0 0.001662 0.037764 0.007902 4.82E-05 0.026226 0.008114 0 0 0 0.000429 0.000122 0 0 0.008723 0.035907 2.43E-21 0 0 0.001632 0.001437 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 108 of 848

StaphylothermusClostridium marinusBacillus novyi-NT-08 strain amyloliquefaciens F1-30Natrialba magadiiThioalkalivibrio strain strain FZB42-30Pseudomonas ATCC sp. 43099-01K90mix-30Lactobacillus putida strainBartonella acidophilus F1-30 quintanaBifidobacterium strain NCFM-01strain Toulouse-01 animalis subsp. lactis strain Bl-04-08 0 5.82E-06 0 0.000179 0.161727 0 0 0.000662 0 0 0 0 0 7.88E-14 0.049558 0 0.001422 0 0 0.000859 0 0 0.076623 0.034663 0 0.001578 0 0 0.001109 0 0 0.126218 0.086237 0 0 0 0 0.003768 0.002797 0 0.023937 0.025771 0 0.005984 0 0.238784 0 0 0 0.019811 0.034747 0 0.002383 0 0 0 0 0 0.12864 0.012958 0 0.008545 0 0.6942 0.005005 0 0.000133 0.175328 0.0572 0 0 0 0.024427 For0 Peer0 0 0.044488Review0.035653 Only0 0.008025 0 0 0.000503 0 0 0.124348 0.017559 0 0.001732 0 0 3.21E-09 0 9.43E-07 0.077106 0.101137 0 0.003547 0 0 0 0.005045 0 0.07875 0.043111 0 0.00366 0 0 0 0 0 0.113054 0.045531 0 0.001469 0 0 0.006314 0.009674 0 0.028578 0.005054 0 0.010321 0 0 0 0.005142 6.02E-08 0.434661 0.021316 0 0.00399 0 1.48E-05 1.70E-18 0.015524 0 0.009656 0.019743 0.000331 0.007152 0 0 0.001884 0.001687 0 0.0625 0.015264 0 0.00401 0 0 0 0 1.62E-09 0.203773 0.030576 0 0.001413 1.23E-07 0 0.000137 0 0 0.088311 0.034959 0 0.001994 0

Wiley-Blackwell and Society for Applied Microbiology Page 109 of 848

ShewanellaSulfurovum trabarsenatis-01Alkaliphilus sp. NBC37-1-30Francisella metalliredigens tularensisBrucella strain suis subsp.Acidovorax QYMF-30 str. 1330-08holarctica Halothermothrixcitrulli strain strain BradyrhizobiumOSU18-08 AAC00-1-08 oreniiParabacteroides strain sp. H ORS278-01 168-01 distasonis strain ATCC 8503-08 0.002703 0.087443 0.021027 0 0 0.016934 0.01792 0.010964 0.015497 0.000226 0 0 0 0 0.001723 0 0.000684 0.014199 0.001053 0 0.000163 0 0 0.00228 1.93E-08 0.002375 0.023297 0.002097 0.052007 9.30E-06 0 0 0.005034 0 0.002011 0.034675 0.000526 0.005592 0.000641 0 0 0.001341 0.000117 0.003527 0.01949 0.004007 0 0.076073 0 0 0.009378 0.000116 0.001455 0.012489 0.001741 0 0.006533 0 0 0.011608 0.00204 0.004134 0.028213 0.004393 0 0 0 0 0.002333 6.61E-10 0.003167 0.033895 0.001545 For0 0.002016 Peer0 Review0 0.002426 6.66E-06 Only0.003709 0.013178 0.002264 0.047285 0 0 0.024005 0.003122 0.00057 0.002474 0.018687 0.002686 0 0.001224 0 0 0.00733 0.001646 0.002538 0.016635 0.003804 0.000123 0.003099 0 0 0.024719 0 0.001578 0.011897 0 0.011976 0.020241 0 0 0.012375 3.37E-05 0.003094 0.021776 0.001785 0 0 0.003535 0.008542 2.42E-05 0.003144 0.003478 0.006337 0.003448 0.199432 0 0 0 0.016112 0.000299 0.003437 0.038253 0.002274 0.00566 0.007351 0 0 0.001931 0.000167 0.004122 0.006601 0.003291 0.012116 0.007367 0.014436 0 0.005163 0.000823 0.003882 0.028 0.002653 0 0 0 0 0.004976 0 0.001203 0.002357 0.004863 0.002614 0 0 0 0.016596 5.77E-05 0.001825 0.012024

Wiley-Blackwell and Society for Applied Microbiology Page 110 of 848

Laribacter hongkongensisBradyrhizobiummarine strain sp. firmicute ORS278-08 HLHK9-08Veillonella HTE831-08 parvulaCoraliomargarita strainPhenylobacterium DSM akajimensis 2008-01Borrelia strainzucineum sp.Sphingobium PBi-08 DSM strain 45221-01Psychrobacter HLK1-01 japonicum strain sp. PRwf-1-08 UT26S-08 0.04147 0.038563 0.013454 0.000234 0.046194 0.023651 0 0.119169 0 0.039619 0.002894 0 4.97E-10 0.058755 0.003036 0 0.02535 0.135861 0.015131 0.015152 0 1.25E-06 0.195424 0.003666 0 0.029511 0.017602 0.010028 0.013414 0 0 0.021616 9.30E-05 0 0.010964 0.059015 0.021985 0.014102 0.000138 0.000879 0.003858 0.004281 0 0.002444 0.011121 0.031459 0.006619 0.00165 2.40E-11 0.157046 0.003493 0 0.0138 0.09391 0.028345 0.013221 0 0.000388 0.028395 0.00624 0 0.049343 0.035006 0.031511 0.023882 0 0.001066 0.100118 0.004525 0 0.023544 0.06933 0.011018 0.007351For0.001639 Peer4.62E-08 0.005661Review0.004685 Only0 0.009692 0.018616 0.024737 0.007012 0.004004 0.000124 0.260919 0.003498 4.61E-09 0.004235 0.10147 0.03332 0.008752 8.12E-05 0.001707 0.399717 0.004889 0 0.00832 0.098242 0.047163 0.015819 0 0 0.004379 0.007124 0 0.014295 0.020806 0.073619 0.01467 0 0 0.056913 0.004936 0 0.017029 0.124842 0.006661 0.003689 0 0.00107 0.005459 0.007159 0 0.013122 0 0.021744 0.040355 0.00642 0.000459 0.003537 0.00818 0 0.023362 0.034399 0.010653 0.004755 9.10E-05 0.000246 0.007111 0.00605 0 0.010777 0.014378 0.028879 0.021543 0.000164 0.001807 0.0287 0.011359 0 0.029482 0.047765 0.014096 0.008808 0.00022 2.15E-05 0.013306 0.002621 0 0.011029 0.029538 0.038942 0.014639 0.001603 0.001326 0.057073 0.005655 0 0.011355 0.096158

Wiley-Blackwell and Society for Applied Microbiology Page 111 of 848

MycobacteriumShigella tuberculosis boydiiExiguobacterium strain CSU#93-30 Sb227-08Denitrovibrio strainYersinia 255-15-08 acetiphilus pseudotuberculosisRhodopseudomonas strain DSMPelobacter 12809-30 strain palustris marinepropionicus YPIII-08 firmicutestrainBorrelia strain CGA009-01 HTE831-01 DSM recurrentis 2379-30 strain A1-08 0 0 0 0.064547 0.00188 0.005246 0.027909 8.30E-08 0 0 0 0.001707 0 0 6.02E-05 0 0 0 0 0 0.000466 0 0 0.000646 0 1.16E-06 0 0 0 0 0 0.019534 0.001274 0.001451 0.00227 0 0.000486 0 0 0.02835 0 0.002081 9.38E-09 0.001236 0.005063 0 0 0.006518 0 0.022394 0.001519 0 0.000794 0 0.004642 0 4.61E-14 0.00906 0 0.001868 0.031179 2.11E-07 0 0 0 0.001955 0 0.048411 0 0 0.000151 0 0.001967 For0 Peer0 0.004429 0.003423Review0.003219 0.003958 Only0.000585 0 0 0 0.003383 0 0 0.001372 6.97E-14 0.000731 0 0 0.002387 0.000321 0.068226 0 0.001648 0.051833 0.000991 0 0 0 0 0.001693 0.018474 0.002725 8.67E-06 7.67E-05 0 0 0 1.04E-08 0 0 0.001372 0.000557 1.21E-06 0 0 0 0 0 0 0.003048 0.000201 9.38E-05 0 0.001982 0 0 0.053844 0 0.004256 0.060699 0.000651 0 0 0 0.001955 0.001202 0 0 0.001506 6.30E-09 0 0 0 0.005074 0.021989 0 0.003332 0.027996 0.000859 0 0 0 0 0.014396 0 0.000956 0 2.52E-05 0 0 0 0 0.025881 0.016985 0 0 2.21E-05 0

Wiley-Blackwell and Society for Applied Microbiology Page 112 of 848

ShewanellaBacillus sp. MR-1-08 anthracisClostridium strainMethylobacillus botulinum Ames-08 ProchlorococcusF strain flagellatus Langeland-08Escherichia strain marinus KT-08 Escherichiacoli str. O103:H2 MIT Natrialba9515-01coli strain 55989-08 12009-30 magadiiMycobacterium strain ATCC avium 43099-08 subsp. paratuberculosis strain K-10-30 0.03787 0 0.000361 0.078393 0 0 0 0.000477 2.93E-07 0.018713 0 0 0.065361 0.001121 0 0 0.015685 0 0.008693 0 0 0.027526 0.001543 0.003477 0 0 0 0.018627 1.88E-09 0 0.074251 0 0 0 0 0 0.011757 0 3.57E-07 0.017682 3.90E-07 0 0.001419 0 0 0.025322 0 0 0.07147 0.003506 0 0 0.00446 0 0.019929 0 0 0.054714 0.000662 0 3.12E-07 0 0.019148 0 0 0 0.060999 0.001191 0 0 0.01376 0 0 For0 0.000646 Peer0.03572 0.003521Review0 Only0 0.004192 0 0.017941 0 0 0.044977 0.002175 0 0.001014 0 0 0.019622 0 0 0.05676 0.003963 0 0 0 0 0.012852 0 0 0.048951 0.002175 0 0 0 0 0.03849 0 0 0.06309 0.004312 0 0.001879 0 0 0.010688 0 0 0.014444 0.007205 0 0 0.003251 0.007453 0 0 0 0.044936 0.004599 0 0 0.000486 4.33E-12 0.014275 0 0 0.030421 0.008263 0 0 0 0 0.013579 0 0.002046 0.065676 0.00378 7.71E-05 0.000374 0.000821 0.002245 0.012996 0 0 0.057432 0.00188 0.000549 0 0 0 0.028955 0 0.000711 0.051293 0.000719 0 0 0.00082 0

Wiley-Blackwell and Society for Applied Microbiology Page 113 of 848

RoseiflexusAcidothermus sp. strain RS-1-30Thermobaculum cellulolyticusRhizobium strainterrenum leguminosarumBacillus 11B-08 strain pumilus ATCCYersinia bv.BAA-798-01strain trifoliipseudotuberculosis ProchlorococcusSAFR-032-01 strain WSM2304-01Bacillus sp.strain cereus MIT9313-30Deinococcus IP 32953-30strain E33L-30 deserti strain VCD115-30 0.031706 0.054946 0.035205 0.004935 0.002159 2.41E-08 0 0 0 0 0 2.89E-08 0.000559 0 0.093086 0 0 0 0 0.01672 9.70E-06 0.002785 2.97E-05 0.000259 2.63E-05 0 0.004138 0.039985 0.005472 0 0.0019 0 0 0.01016 0 0.001987 0.007898 0.001473 0.000129 0.002341 4.52E-05 0 0.02366 0 0.000533 0 0.000341 0.000143 0.003788 6.49E-05 0.044263 0.155991 0 0 0.026407 0.007708 0.002882 0.004344 0.000371 7.75E-05 0 0 0 0 0 4.46E-08 0.005231 0.000562 0.222848 0 0 0 0.006612 0.005265For0.00103 Peer0.003513 Review0 0.000166 0.009297 Only 0 0 1.25E-08 0 1.95E-12 0.00384 0.000312 0 0.007964 0 0 0.075783 8.61E-10 0.000215 0.006123 0 0 0.091183 0 0.031947 0 1.10E-06 0.000145 0.003514 9.34E-06 0.01809 0.022343 0.000859 0.001065 0.017198 0.002818 3.10E-09 0.008578 2.23E-05 0.011575 0.036304 0 0 2.98E-05 0.00385 0.000454 0.004077 0.000102 0 0.03711 0 0 0.027347 0.009467 0.005223 0.005001 0.001083 5.72E-05 0 0 0 0.012562 0.003693 0.000612 0.002055 0.000172 0.004744 0.017034 0 0.001594 0.007846 0.016859 0.002309 0.00775 0.00096 6.24E-08 0.008233 6.44E-08 0.003445 0.010862 5.58E-06 7.29E-12 0.000913 1.83E-13 0.012739 0 0 0 0.00194 0 0.000389 0.011123 7.72E-07 0.001447 0.021043 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 114 of 848

Wautersia taiwanensisVibrio choleraeSulfolobus (Chen strain et al. MJ-1236-01islandicusProchlorococcus 2001) Vaneechoutte strainMycobacterium M.14.25-08marinus etGemmatimonas al. str. tuberculosis2004-01 MIT Pedobacter9301-30 aurantiaca strainSynechococcus heparinus KZN strain 1435-08 strainRhodobacterT-27-08 sp. DSM PCC 2366-017425-30 sphaeroides strain KD131-01 0.003573 0 0 0 0.005928 0.09089 0.026909 0.086818 0.008801 0.000621 0 0 0.407302 0 0.000243 0.011023 0.20848 0.002637 0.001285 0.002091 0 0 0 0.004664 0.012771 0.071288 0.008742 0.000857 0.007364 0 0 0 0.003571 0.034995 0.055433 0.056141 0.002151 0 0 0 2.76E-05 0.00027 0.013129 0.036398 0.027739 0.002829 0 0 0 0.000131 0.000222 0.021013 0.143413 0.018003 0.006013 0.002486 0 0 0 0.030801 0.01971 0.066155 0.021501 0.005921 0.009353 0 0 2.16E-05 0.013292 0.037785 0.19037 0.025721 0.000788 For0 Peer0 0.076145 Review0 0.003796 0.008512 Only0.032054 0.026819 0.002279 0 0 0.100468 0.000263 0.002517 0.022252 0.189984 0.013853 0.001879 0 0 0.009679 6.71E-05 0.005315 0.023731 0.072812 0.02363 0.001532 0 0 0 0 0.001518 0.022287 0.037494 0.039716 0.003584 0.017405 0 0.02758 0.009548 0.002882 0.031797 0.184916 0.007166 0.001962 0.0034 0 0.039438 7.63E-05 0.006912 0.016742 0.05779 0.021325 0.005586 0.004136 0 0 0 0.070696 0.010828 0.009797 0.020211 0.000759 0.000865 0 0.028054 0.00127 0.00852 0.007045 0.02926 0.001664 0.00243 0.005252 0.000531 0.015329 0 0.07198 0.01771 0.009568 0.002224 0.000636 0.003209 0 0 0 0.00417 0.007223 0.104074 0.021415 0.001744 0 0 0.097394 0.000747 0.006131 0.033 0.07518 0.005416

Wiley-Blackwell and Society for Applied Microbiology Page 115 of 848

BacteroidesLeuconostoc fragilis strainPelobacter mesenteroides NCTC 9343-01 Yersiniacarbinolicus subsp. enterocoliticaSeattle strainmesenteroides DSMAquarium Ferroglobussubsp. 2380-08 strain strainenterocoliticaShewanella ATCCplacidus SCM1-08 8293-30 strainstrainRickettsia denitrificans DSM8081-30 10642-30massiliaeEhrlichia strain OS217-30strainruminantium MTU5-08 strain Gardel-01 0.004895 0 0.063328 0 7.790119 0.001217 0.032058 0 0.001579 0.000261 0.197199 2.16E-05 0 0 0 0.011879 0.012443 1.33E-08 0.000713 0 0.003556 0.008272 0.008647 0.003725 0.013609 0 0.000286 0.000692 0 0.016267 0 0.009603 0 0.066344 0 0 0.000912 0.022075 0.030178 0 5.71E-05 0.011694 0.020052 0 0 0.002066 0 0.012829 0.080105 0.144564 0.113521 0.012414 0 7.99E-06 0.001556 0 0.007551 0 11.28953 4.73E-11 0.049085 0.01084 0.001927 0.001809 0.237644 3.79E-23 0 0.613213 0 0.002795 0 4.77E-09 9.10E-05 For0 0.001256 Peer0 0.061914Review0 0.041356 Only 0 0.001324 0.001888 0 0.010741 0 0.405049 0 0.031264 0.005688 8.34E-06 0.003683 0 0.011119 0.013297 0.478954 0 0.000322 0.027153 0.00294 0.00052 0.039433 0.030817 0.022647 0 0 0.181859 0 5.02E-05 0.003573 0 0.025899 0 0.078297 0 0.033754 0 0 0.000861 0 0.003718 0 0.010514 0.000366 0.017039 0 0.002033 0.002326 0 0.048341 0 11.31054 0.008159 0.032596 0 0.000246 0.001078 0 0.009554 0 0.005134 0 0.096025 0 0 0.001428 0 0.0378 0.000255 9.289042 0.001093 0.011889 0.010366 0 0.000186 0 0.000214 0.041462 0.00646 0 0.054296 0 0.000536 0.001979 0 0.003333 0.001301 0.06443 0 0.081964 0.001078 3.67E-05

Wiley-Blackwell and Society for Applied Microbiology Page 116 of 848

Erwinia amylovoraRalstonia strain pickettiiSanguibacter CFBP1430-30 strainHaloarcula 12D-08keddieii strainmarismortuiRhodopirellula DSM 10542-01Thermococcus strain baltica ATCC strainSpirosoma 43049-08 kodakarensis SH 1-01 lingualeYersinia strain strainpestisHistophilus KOD1-01 DSMstrain 74-08 Pestoides somni str. F-30 129PT-01 0.001855 0.005504 0.000965 0 0.073257 0.00129 0.059119 0 0.002031 0.000222 0.021174 0.000898 0 0.000505 0 0.031765 0 0.002886 0.000887 0.002683 0.000252 0 0.001626 0 0.02867 0 0.003436 0.034378 0.002658 1.12E-05 0 7.51E-07 0 0.041162 0 0.003676 0.001407 0.003279 0.000244 0 0.00149 0 0.030162 0 0.003592 0 0.021853 1.42E-13 0.004637 0.000474 4.77E-13 0.032511 0.00785 0 0 0 0.000438 0 0.00347 0 0.039256 0.013306 0.008876 0 0.026864 3.52E-05 0 0.004333 5.24E-05 0.026927 0.208763 0 0 0.001889For6.52E-05 Peer0 0.002368Review0 0.017138 Only 0 0.003751 0 0.016967 0 0 0.001322 0 0.025152 0 0.002927 0 0.021366 7.42E-05 0 0.002773 0 0.024204 0 0.005239 0 0.008787 0.000103 0 0.00267 0 0.034568 0 0 0.002422 0.024779 0 0.000743 0.001221 0 0.027771 0.012669 0 0.000451 0.00248 0.001925 0 0.004612 0.000105 0.00977 0.003421 0.002476 0 0.011271 0.000306 0.00517 0.003054 0 0.037955 0.014731 0.005549 0 0.003893 0.000805 0 0.014949 0 0.010316 0.00232 0.001591 0 0.005553 3.92E-05 0 0.004387 0.001679 0.032628 0 0.008609 0 0.004205 3.06E-06 0 0.000227 0 0.011913 0.010749 0.000498 0.012264 0.015077 8.45E-05 0 0.000772 0 0.029746 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 117 of 848

Brucella melitensisHaemophilus biovarArthrobacter ducreyi Abortus str.Propionibacterium strain aurescens 35000HP-30 2308-30Ureaplasma strain TC1-01acnesHistophilus urealyticum strain SK137-08 Anaeromyxobactersomni ATCC str. 700970-01 129PT-08Cellvibrio dehalogenans japonicusDesulfitobacterium strain strain Ueda107-08 2CP-1-30 sp. Y51-01 0 0 0.002445 0.381186 0 0 0.073763 0.178204 0.002459 0 0 0.000112 0.041897 0 0 0 1.164202 0 0 0 0.000419 0.021016 0.003021 0.006186 0 0.44033 0.000435 0.001178 0.131188 0 2.78E-08 0 0.013036 0 0.657354 4.16E-13 0 0.008671 0.000602 0.010115 0 0.009058 0 0.321987 2.06E-05 0 0 0.000891 0 0 0.058605 0 1.006968 0.000395 0 0.059205 0.000299 0 0 0.008551 0.000346 0.349331 0 0 0 0.001098 0.036756 0 0.070515 0 1.398494 2.59E-05 0 For0 5.70E-05 Peer0 Review0 0.007296 Only0 0.214287 1.21E-05 0.017356 0.004021 0.000202 0.001932 0 0.040841 2.13E-16 1.057627 5.90E-05 0 0.020448 9.82E-05 0 0 0.03713 0 1.422764 0.000327 0 0.167756 0.000549 9.15E-07 0 0 0 0.576906 7.43E-05 0.020672 2.75E-06 6.69E-05 0.015487 0 0.07029 0 1.357746 0.000106 0 0.002635 9.78E-05 0.000521 0 0.02956 0 0.066726 4.73E-05 0 0.032916 0.000648 0 0 0 0.020492 0.387224 0.000407 0 0.051264 1.64E-05 0 0 0.00794 5.91E-07 0.227784 2.12E-05 0 0 0.00075 0.028172 0 0.015653 0.016731 0.32895 0.00307 0 0.035241 0.000149 0 0 0 0.010796 0.457631 8.55E-08 0 0 0.001991 1.27E-08 0 0.05596 0 1.045063 2.03E-05

Wiley-Blackwell and Society for Applied Microbiology Page 118 of 848

Francisella tularensisFinegoldia subsp. magnaChitinophaga novicida strainEscherichia ATCC pinensis U112-30 29328-30 Capnocytophagastraincoli strain DSM BW2952-08 Bifidobacterium2588-30 ochraceaMethanocorpusculum strain dentium DSMNitrobacter strain 7271-08 Bd1-08 Methylocellalabreanum winogradskyi strain sp. strain BL2-30 Z-30 Nb-255-08 0 0 0.066694 0 0.15422 0 0.040027 0.101789 0.001515 0 0 0.046712 0.001458 1.13348 0 0 0.007011 0.062262 0 0 0.058039 0 0.685323 0.000402 0 0.02926 0.002456 0 0 0.089912 0 0.619019 0 0 0.018015 0.06659 0 0 0.041322 0 0.685387 0 0 0.035451 0.006908 0 0 0.091806 0 0.91005 0 0 0.048833 0.000227 0 0 0.058185 0 0.40826 0 0 0.02964 0.004985 0 0 0.070452 0.007228 1.461216 0 0 0.026617 0 0 For0 0.014913 Peer0 0.386902Review0 Only0 0.012447 0.014137 0 0 0.077048 0 1.11483 0 0 0.013855 0 0.057302 0.048284 0.056699 0 0.694844 0 0 0.016027 0.000382 0.002186 0 0.062332 0 0.832914 0 0 0.068887 0.002029 0.062212 0 0.03467 0 1.054631 0 0 0.024536 2.99E-07 0 0 0.057284 0 0.155234 0 0.027126 0 0.01289 0 0 0.093936 0 0.406169 0 0 0.019484 0.048072 0.033444 0 0.05085 0 0.151985 0.001054 0 0.015741 2.85E-05 0.049636 0.000685 0.078172 0 0.291635 7.94E-05 0.026778 0.031016 0.026898 0 0 0.016627 0.002985 0.533432 0 0 0.016869 2.68E-05 0 0 0.036123 0 0.885239 0.001602 0 0.030498 0.000127

Wiley-Blackwell and Society for Applied Microbiology Page 119 of 848

LactobacillusProchlorococcus delbrueckiiNitrosospira subsp. sp. MIT9312-01bulgaricusRhodopseudomonas multiformis strainStreptococcus strain ATCC ATCC 11842-30palustrisAnoxybacillus 25196-30pyogenes strainClostridium MGAS8232-01 BisA53-01flavithermusPelodictyon beijerinckii strain RickettsiaWK1-01 strainphaeoclathratiforme NCIMB bellii 8052-01 strain RML369-C-30strain BU-1-01 0 0.00656 0.088799 0.008709 0 0.027876 0.000384 0.016067 0 0 1.11E-05 0 8.62E-05 0 0.001287 2.20E-08 0.000633 0 0 0.000329 0.022846 0.001003 0 0.00782 4.25E-13 0.00137 0 0 1.23E-07 0.025204 0.001083 0 0.000224 1.53E-07 0.006373 0 0 0.000627 0.020864 0.002696 0 0 9.75E-05 0.001418 0 0 0.005661 0.044651 0.002132 0 0.000338 8.88E-05 0.004118 0 0 0 0.039348 0.003189 0 0.004631 0.000489 0.00888 0 0 0.000114 0 0.001385 0 0.001104 0.0007 0.004457 0 0 0.001732For0.005381 Peer0.001631 Review0 0.000238 1.01E-06 Only2.32E-05 0 0 0.000502 0 0.001421 0 0.001222 1.01E-13 0.002885 0 0 0.000736 0.112679 0.001715 0 0.001545 0.000526 0.003671 0 0 0.001035 0.005604 0.003069 0 0.000867 1.23E-05 0.000306 0 0 0.005398 0.043443 0.00186 0 0.00337 2.05E-09 0.006416 0 0 0.001897 5.58E-06 0.003591 6.34E-07 0.001661 0.000339 0.003098 9.40E-14 0 0.005505 0.391636 0.00507 7.20E-06 0.010328 0.000717 0.004719 0.037241 0 0.001615 0.014842 0.002832 0.000113 0.00086 0.000119 0.00046 0 0.001253 0.004063 0.086153 0.003067 0 0.002568 0.000559 0.003793 0 0 0.001748 0.044278 0.000483 0 0.003437 3.86E-07 0.002332 0 0 0.000612 0.02889 0.003444 0 0.00199 4.14E-07 0.004396 0

Wiley-Blackwell and Society for Applied Microbiology Page 120 of 848

Bacillus megateriumStreptococcus strainGeobacillus pneumoniae QM B1551-30Bacillus sp. Y412MC10-01 strain pumilus HalobacteriumCGSP14-08 strain DesulfatibacillumSAFR-032-30 sp. NRC-1-01Leptospira alkenivorans interrogansProchlorococcus strainBeutenbergia serovar AK-01-01 marinus Lai str. cavernaestr. 56601-30 MIT 9515-30 strain DSM 12333-01 0.001492 0 0.003222 0 0.003355 0.015623 0.005004 0 0.004863 0 0 8.02E-09 0 0 7.82E-06 0 0 5.82E-06 0 0 2.61E-06 0 0 0.000227 0 0 5.21E-08 0.024127 0 4.64E-06 0 0 0 0 0 2.94E-05 0 0 0 0.003366 0 0.000475 0.001571 4.11E-09 0.001827 0 0 0.000132 0 0 0.000604 0 0.328536 1.74E-05 0 0 8.78E-05 0 0.000116 0.002412 0.00057 0 0.000192 0 0 0.000648 0 0 0.002296 0 0 0.000674 0.000844 For0 6.56E-05 Peer0 Review0 4.10E-06 0.012185 Only0.028645 1.50E-05 0 0 0.000403 0 0 0.001305 1.57E-14 0.144504 4.89E-08 0 0 9.24E-05 0.010863 0 0.001445 6.68E-06 0.008983 2.88E-05 0 0 0 0 0 0.000126 0.003241 0 1.62E-05 0.000103 0 2.52E-06 0 0 0.002434 1.38E-05 0.090814 2.52E-08 0.005729 0 5.74E-05 0 0 0.001103 0 0.060148 0.000278 0.011629 0 0.001029 0.003832 0 0.002792 0.026266 0 0.000468 3.27E-06 1.01E-10 3.33E-05 0 3.98E-05 3.57E-05 0.003732 0.073097 0 0.002201 0 0.000422 0 0 0.003457 0.040823 0 0.001627 0 0 6.55E-05 0 0 1.98E-07 0 0 0 0.007234 0 1.05E-05 0 0 1.16E-05 5.51E-05 0.068486 0

Wiley-Blackwell and Society for Applied Microbiology Page 121 of 848

ProsthecochlorisHalobacterium vibrioformisBordetella sp. DSMNRC-1-08 parapertussisActinobacillus 265-01 Paenibacillus strain pleuropneumoniae 12822-01Alteromonas sp. JDR-2-30 Desulfovibrioserovar macleodii 3 str.Campylobacter 'Deep magneticusJL03-08 ecotype'-01Anaeromyxobacter strain jejuni RS-1-08 subsp. jejuni dehalogenans strain NCTC strain 11168-01 2CP-1-01 0.029746 0 0.002742 0 0.019177 0.067889 0.008226 0.001136 0.004954 3.28E-05 0 0.000437 0 0 0.005628 0 0 5.29E-07 0.001066 0 0.000843 0 0.000352 0.011173 0.002316 0 1.17E-07 0.001092 0 0.001602 0 0 0.039178 0.000504 0 2.14E-21 0.000714 0 0.001498 0 0.000329 0.035075 0.003007 0.000799 2.12E-07 0.001279 0 0.001828 0.068618 0 0.032234 2.97E-05 0.000387 0.000779 0.005145 0 0.003256 0 0.003679 0.041558 7.31E-07 0.000489 0.000608 0.003356 0 0.001232 0 0.026159 0.028604 1.27E-05 0.000121 0.000885 0.001076 0.00042For Peer0 0 4.26E-10Review0.032382 0.0024Only0.000336 2.85E-05 0.000736 0 0.000889 0.013321 0 0.02123 4.27E-09 0 0.000427 0.002415 0 0.002149 0 0 0.030057 2.50E-05 0 0.000478 0.002889 0 0.001081 0 0 0.062858 0 2.21E-08 7.87E-05 0.002616 0.000245 0 0 5.18E-06 0.053781 0.002523 0 0.000145 0.002633 0 0 0 5.92E-07 0.013291 0.000533 0 0.000344 0.007553 0 0 0 0.008285 0.022284 0.00616 0 0.001813 0.003171 0 0.001037 0 0 0.01001 0.000268 0 0.000326 0.007028 1.03E-05 0.001737 0 0.005364 0.024287 0.006545 0.000932 0.001299 0.001206 0 0.000396 0 0.002042 0.030575 0 0.000237 3.11E-05 0.003546 0 0.002323 0 0.011851 0.05631 0.000256 9.15E-14 0.000107

Wiley-Blackwell and Society for Applied Microbiology Page 122 of 848

HyperthermusRhizobium butylicus sp.Bifidobacterium strain NGR234-30 DSMClostridium 5456-30 animalisSphingomonas beijerinckii subsp. lactisBrucella strain wittichiistrain NCIMB melitensis DSMVerrucomicrobiae strain 8052-30 10140-01 RW1-01strainCloacamonas ATCC bacterium 23457-30Thauera acidaminovorans-30 V4-01 sp. MZ1T-01 0 0.037023 0 0.037338 0.017206 0.067665 0.053466 0.299162 0.016191 0 0.002797 0 0 0.001388 0 7.97E-08 0 0.000969 0 0.004538 0 0.002583 0.00209 0 3.16E-05 0 0.001376 0 0.065008 0 0 0.003818 0 5.88E-05 0 0.003135 0 0.028956 0 0 0.002922 0 0.000121 0 0.005565 0 0.102811 0 0 0.003912 0 0.00031 0 0.005105 0 0.01406 0 0 0.006269 0.041033 0.002648 0 0.010541 0 0.027431 0 0 0.00283 0.017839 0.001964 0 0.009815 0.02301 0.016198For Peer0 6.57E-06 0.003998Review0 2.64E-09 Only 0 0.003371 0 0.014793 0 0.003827 0.001681 0 2.89E-08 7.12E-15 0.003676 0 0.001119 0 0.000132 0.003209 0 0.000805 0 0.006 0 0.005055 0 0 0.004511 0 4.77E-07 0.034581 0.005301 0 0.014834 0 0.016628 0.003415 0 1.42E-08 0 0.011913 0 0.001916 0.000158 0 0.006728 0 4.34E-14 0.025429 0.006221 0 0.045384 0 0.00374 0.004708 0 0.003912 0.003542 0.006098 0 0.013526 0 0 0.003544 0 8.71E-07 0 0.002182 0 0.016991 0 0.000251 0.004744 0 0.001488 6.55E-09 0.008183 0 0.029518 0 0.003497 0.000967 0.01669 0 0 0.001743 0 0.019534 0 0 0.003801 3.37E-10 0.000289 0 0.0084

Wiley-Blackwell and Society for Applied Microbiology Page 123 of 848

ChloroherpetonThermobifida thalassiumRubrivivax fusca strain strain gelatinosusXenorhabdusATCC YX-30 35110-01 VibrioPM1-08 bovienii vulnificus strainBurkholderia str. SS-2004-30 YJ016-30Mycobacterium cenocepaciaPyrococcus HI2424-30 leprae Blattabacterium abyssistrain Br4923-30strain GE5-30 sp. Alboraia-08 0.05746 5.36E-14 0.036557 2.35E-14 0.059558 0 0 0 0 0.000116 0 0.052493 0.010676 0 0.033625 0 0 0 0.000218 0.000248 0.028975 0.019145 0 0.009999 0 0 0 0.00181 0.000707 0.030514 0.053494 0 0.002421 0 0 0 0.002493 0.002323 0.005643 0.008401 0.090784 0.002519 0 0 0.055095 0.002086 0 0.074227 0.049789 0.475927 0.097369 0 0 0.061388 0.001778 0.040664 0.020237 0.046815 0 0.009232 0 0 0 0.006215 3.21E-05 0.114824 0 0 0.213386 0 0 0 0.001207 For0 0.005819 Peer0.010442 0.053992Review0.011743 Only0 0 0.039263 0.001746 2.04E-12 0.050555 0.041633 0.108281 0.000153 0 0 0 0.003398 0 0.072132 0.020852 0.061718 0.063978 0 0 0 0.004316 0.001132 0.011426 0.009079 0.285593 0.012135 0 0 0 0.002985 0 0.102204 0 0.048738 0.002581 0 0.005314 0.143879 0.001105 0 0.000609 0.002433 0.030187 0.050432 0 0.014208 0 0.007291 0.044937 0.053701 0.014216 0.061474 0.016077 0.002423 0 0.085426 0.003264 0.000222 0.001907 0.014097 0.116475 0.009481 0 0 0.031673 0.010317 0.015859 0.03591 0.006739 0.022577 0.003383 0.008086 0.016441 0 0.001331 0.010301 0.02153 0.037989 0.083472 0.002173 0 0 0.021909 0.004694 0.013304 0.073419 0.012427 0.052941 0.014604 0 0 0.086217

Wiley-Blackwell and Society for Applied Microbiology Page 124 of 848

AggregatibacterBifidobacterium aphrophilusClostridium longum strainPropionibacterium botulinum NJ8700-30 str. DJO10A-08 ShewanellaB1 strain acnes Okra-08Bacillus trabarsenatis-08 strain subtilis SK137-30Stenotrophomonas subsp. Buchnerasubtilis str. maltophilia sp. BuchneraBGSC APS-08 1A700-30 strain aphidicola K279a-08 str. Cc (Cinara cedri)-01 0 0 0 0 0 0 0.016483 0 0 0 0 0 0 0 0 0.026458 0 0 0 0 8.09E-08 0.02044 0.004782 0 0.01203 0 0 0.090606 0 0.000858 0 0 0 0.011972 0 0 0.003866 0 0 0.018394 0.005685 0 0.004954 0 0.002744 1.26E-06 0 0 0 0.024875 0 0.010522 0 1.44E-05 0.055127 0 0 0 0.017694 0.021937 0.002074 0 0.002665 0 0 0 0.586119 0.040537 0 0.004745 0 2.08E-05 0 For0 Peer0 0.009298 0.01693Review0 0.005176 Only 0 0.008427 0 0 0 0 0.022311 0 0.009311 0 0 0.01857 0 0.002398 0.044614 0.020582 0 0.009812 0 0.012612 0.002134 0 0 0.041572 0 0 0.006743 0 0.004559 0 0.000763 0 0.079971 0.03589 0 0.027948 0 2.99E-21 0 0 0.000235 8.81E-12 0.00755 0 0.000816 0 0.016362 0.084252 0 0.000103 0 0 0.002962 0.036972 0 0.000111 0.006534 0.003236 0 0.01471 0.007099 0 0.001654 0.012433 0.003844 0.007984 0 0.00111 0.064707 0.009101 0.00259 0.01058 0 2.04E-09 0 0 0.002588 0.058932 0.014397 0 0.003944 0 0.004789 0.006601 0 0.000679 0 0.023517 0 0.018733 0 4.23E-11

Wiley-Blackwell and Society for Applied Microbiology Page 125 of 848

RhodopseudomonasProteinoruptor palustrisNeisseria kamchatkensis strain meningitidisYersinia HaA2-30 1221n-30pestis Bifidobacteriumserogroup strain CO92-30 ANovosphingobium strain lactis Z2491-01 AD011-01Escherichia aromaticivorans Gardnerellacoli O157:H7Shewanella vaginalis strain EDL933-08 DSM strain baltica 12444-08 409-05-01 strain OS223-30 0.085597 0 0 0 0 0.102891 0 0.001294 0 6.35E-10 0 0.001145 0 0 0.056538 0.006364 0 4.62E-08 0.000885 0 0.001521 0 0 0.035403 0.001874 0 0 0.036016 0 0 0 0 0.021807 0 0 0 0.005043 0 0.00197 0 0 0.022959 0.001688 0 0.01228 0 4.05E-09 0 0 0 0.02116 0 5.98E-08 0.002886 0.03192 0 0 0 0 0.057501 0 2.66E-07 0.018526 0.02313 0 0.00552 0 0 0.045947 0 0 0 0.017276 For0 Peer0 0 Review0 0.009273 Only0 0 0 0.0055 0 0.002701 0 0 0.014085 0 0 0.010248 0.004562 0 0 0.033918 0 0.012707 0.009397 0 0.052865 0.005201 0 0 0 0 0.0321 0 0.000767 0 0.006069 0 0 0 0 0.041009 0 5.67E-14 0.026182 0.001283 0 0 0 0 0.010583 0 0.000866 0.003581 0.024318 0 0.004442 0 7.57E-05 0.044212 0 0 0 0.007502 0.000342 0 0 0 0.01168 0 0.000271 0.022908 0.013765 0 0.003967 0 0 0.02038 0 0 0.011108 0.00115 0 0.000588 0 0 0.01232 0 3.73E-05 0 0.001133 0 0 0 0 0.029577 0 0 0.019524

Wiley-Blackwell and Society for Applied Microbiology Page 126 of 848

AcidaminococcusComamonas fermentansPyrococcus testosteroni strain Neisseriafuriosus DSM strain 20731-08 strain CNB-2-08meningitidisYersinia DSM pestis 3638-30 Rickettsiastrain strain 053442-08 Nepal516-01peacockiiBuchnera strain aphidicolaBurkholderia Rustic-01 str.Salmonella Sgambifaria (Schizaphis enterica strain graminum)-30 MC40-6-30 subsp. enterica serovar Newport strain SL254-08 0.004443 0.020808 0 0.011251 0.002327 0 0.171979 0 0 0.014958 0.023579 0 0 0.000159 0.001087 0 0.005335 0 0 0.009552 0 0 0 0.002876 0 0 0 0.006842 0.003149 0 0 0 0.000274 0 0.01589 0.002067 0 0.004982 0 0 0 0 0 0.01057 0 0.008507 0.019373 0 0 0 0 0 0.049068 0.002033 0.00478 0.004538 0 0.006995 0 0 0 0.01315 7.47E-11 0 0.008856 0 0 0 0.002176 0 0.003285 0 0 0.011011For Peer0 0 Review0 0.004922 0.020752 Only0.000762 0 0.004086 0.011607 0 0 0 0 0 0.024296 0 0 0.01617 0 0.019301 0 0 0 0.021375 0 0 0.00433 0 0 0 0 0 0.011131 0 1.40E-06 0.027659 0 0.022484 0 0 0 0.002997 0 0 0.002832 0 0 0.000298 0.004032 0 0.001033 0 0.000106 0.010397 0 0 0 0 0 0.01318 0 0.000503 0.003551 0 0 0 0 0.004149 3.24E-09 0 0.016992 0.005405 0.011255 0 0 0 0 0.003386 0 0.004562 0.002587 0 0 0 0 0 0 0 0.00048 0.015377 0 0 0 0 0 0.001893 0

Wiley-Blackwell and Society for Applied Microbiology Page 127 of 848

Brucella melitensisMethanocaldococcus strainTeredinibacter ATCC 23457-08 vulcaniusTropheryma turnerae strainHelicobacter whippleistrain M7-01 T7901-01 str.Thermotoga pylori TW08/27-01 strainFrancisella sp. 26695-01 RKU-1-01 philomiragiaPorphyromonasSodalis subsp. gingivalis glossinidius philomiragia strain strain ATCCstrain 'morsitans'-08 33277-01 ATCC 25017-01 0 0.001437 0.049214 0 0 0 0.010127 0.007916 0 0 0 0.016319 0.004103 0 0 0.01195 0.002421 0.019328 0.016413 0.000436 0.048518 0 0 0 0.008474 0.002099 0.007171 0 0 0.126434 0 0 0 0.016207 0 0.004167 0 0 0.062158 0 0 1.08E-17 0.005817 0.003369 0.006604 0 5.40E-10 0.113392 5.51E-05 1.37E-10 0 0.019327 0 0.00843 0 0 0.110861 0 0 0.001664 0.016292 0.004932 0.00434 0 0 0.07973 0 0 0.000687 0.017876 0.006527 0 0 For0 0.059624 Peer0 Review0 0 0.012375 Only 0 0.002735 0.017032 0 0.108152 0 3.03E-11 8.74E-09 0.013848 0.00402 0.004678 0.00414 0 0.061652 0 2.26E-10 0 0.02443 0.007952 0.007876 0 0 0.106198 0 0 0.000107 0.010629 0 0.002993 0 0 0.259531 0 0 0 0.025121 0.005376 0.020666 0 0 0.035848 0 2.81E-05 3.48E-06 0.010849 0 0.0011 0 1.01E-08 0.05999 0 0 1.24E-07 0.018189 0.006656 0.006547 0 0 0.027532 0 0 5.31E-15 0.004438 0 0.000971 0 8.16E-06 0.08754 0 0 0.000548 0.02487 0.003069 0.003644 0 0 0.018725 0 0 0 0.006973 0.00342 0.00163 0 0 0.242817 0 0 0 0.015004 0 0.014534

Wiley-Blackwell and Society for Applied Microbiology Page 128 of 848

Haloferax volcaniiPseudomonas strainWautersia DS2-01 syringae metalliduransNitrobacter pv. syringaeXylella hamburgensis strainCH34-08 fastidiosa B728a-08Xanthomonas strain 9a5c-01 X14-01Brachybacterium axonopodisTeredinibacter pv. faecium citriStreptococcus str. strainturnerae 306-01 DSM strain pneumoniae 4810-30 T7901-30 strain 70585-01 0.002721 0.018297 0.025995 0.012758 0.003541 0.001841 0 0.073404 0 0 0.090966 0.012407 0.001049 0.000244 0.000286 0 0.197879 0 4.48E-18 0.031539 0.003305 0.001679 0.002028 0.000748 0 0.292827 0 0 0.044138 0.010388 0.004795 0.000365 0.001016 0 0.948545 0 0 0.026493 0.005274 0.002117 0.003 0.001772 0 0.335518 0 0 0.106226 0.009919 0.001069 0.002623 0.001757 0 0.631271 0 7.16E-07 0.024851 0.00715 0.002739 0.003365 0.002804 0 0.275951 0 0 0.130875 0.016516 0.00318 0.001909 0.001357 0 0.324783 0 0 For0 0.004293 Peer0.002987 0.001634Review0.000998 Only0 0.298253 0 0 0.076877 0.010842 0.002661 0.000942 0.000894 3.14E-23 0.441817 2.83E-08 1.16E-06 0.088003 0.015856 0.002788 0.001751 0.002252 0 0.66387 0.000429 0 0.042857 0.004258 0.001832 0.001545 0.000583 0 0.52738 0 0 0.127036 0.023875 0.001737 0 0 0 0.578667 0 1.26E-07 0.007837 0.001912 0.004481 0.001197 0.001361 0 0.062502 0 1.83E-07 0.04556 0.008158 0.003057 0.001453 0.002009 0 0.334672 0 0 0.015885 0.001956 0.002155 0.000738 0.001355 0 0.33213 0 0.000827 0.03019 0.009854 0.002562 0.003507 0.002646 0.001726 0.157433 0 0 0.03592 0.008131 0.001445 0.000362 0.000671 0 0.502768 0 0 0.119723 0.013637 0.001813 0.001599 0.001525 0 0.561829 0

Wiley-Blackwell and Society for Applied Microbiology Page 129 of 848

RhodobacterLactobacillus capsulatusPseudomonas straingasseri SB1003-30 strainGeodermatophilus aeruginosa ATCC 33323-08Paramecium str. PAO1-30obscurusSulfolobus bursaria strain Chlorellaacidocaldarius[Mesorhizobium] DSM 43160-01 virusJonesia PBCV-1-08 NCIB sp. denitrificans 11770-08 BNC1-01bacterium strain EX-H1-30 DSM 20603-30 0.058759 0 0.056257 0.003701 0 0 0.035949 0 0 0.13766 0 0.035451 0.001469 0 0 0.003878 0 0 0.256534 0 0.02006 0.003293 0 0 0.008866 0.044983 0 1.059381 0.008589 0.177415 0.00991 0 0 0.009461 0 0 0.439761 0 0.03246 0.001053 0 0 0.006708 0 0 0.165939 0 0.098019 0.002761 0.059927 0 0.010769 0 0 0.143901 0 0.026563 0.002275 0 0 0.01637 0 0.0758 0.345217 0 0.037315 0.000269 0 0 0.008572 0 0 0.156772 For0 0.035796 Peer0.002803 Review0 0 0.01165 Only 0 0 0.054495 0 0.048804 0.003271 0 0 0.005843 0 0.062063 0.301686 0 0.085222 0.000642 1.88E-08 0 0.011731 0 0 0.075394 0 0.087084 0.003842 0 0 0.010176 0 0 0.144314 0 0.044141 0.001556 0 0 0.018516 0 0 0.039637 0 0.008445 0.004873 0 0 0.011382 0.001382 0 0.108561 0 0.059646 0.001642 0 1.91E-09 0.011024 0.024519 0.0064 0.118228 0 0.057299 0.003319 0.001503 0 0.011069 7.02E-05 0 0.083 0 0.016185 0.002258 0 1.90E-07 0.015211 0.009843 0.041534 0.212915 0 0.06061 0.006572 0.032134 0 0.003062 8.24E-08 0 0.238587 0 0.055498 0.001178 0 0 0.010088 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 130 of 848

Salmonella Burkholderiaenterica subsp.Mycobacterium vietnamiensis entericaProchlorococcus serovar marinumstrain Paratyphi endosymbiontG4-08 strain sp. MED4-01 BM-08 strainSalmonella of SPB7-30Acanthamoeba Escherichiaenterica subsp. sp. Bacilluscoli UWE25-30 strainenterica megaterium MG1655-08Borrelia serovar hermsii strain Dublin QM strain strain B1551-08 DAH-01 CT_02021853-08 0.055638 0.015116 0.003825 3.34E-17 0.092797 0.006666 0 0 0 0 0.003447 0.002437 0.000173 4.70E-07 0 0 0 0 0 0.003995 0.000428 0.002175 0.030948 0 0 1.37E-05 0 0.002185 0.003576 0.001221 1.97E-07 0.055191 0 0 0.001351 0 0.012261 0.002569 0.000432 0.002027 0.017645 0.001149 0 6.92E-05 0 0 0.007131 2.05E-07 0.001822 0.155317 0 0 0.003587 0 0 5.18E-05 1.41E-06 0.007774 0 0 0 0.002198 0 0 0.006516 0.00643 0.003167 0 0 0 0 0 0 0.000228For0.000666 Peer0.002543 0.006678Review0 Only0 2.86E-05 0 0 0.01185 0.000886 0.003281 0 0 0 0.002119 0 0 0.013028 0.001493 0.000859 0.091047 0 0 0.00171 4.42E-09 0 0.00124 0 0.004916 0 0 0 0 0 0.000357 0.010861 0.004417 0.00471 0.005861 0 0 0.000586 0 0.001753 0.000753 0 0.032702 0.022985 0 0 0.001579 0.002067 0 0.007356 0.003717 0.006011 7.72E-05 0 0 0.004105 5.96E-14 0 0.002287 7.71E-05 0.057071 0.002008 0 0 0.000233 0.000144 0.00053 0.001976 0.0035 0.004387 0.064833 0 0.001809 0.003577 0 0.005065 0.003282 0.000863 0.000146 0 0 0 4.19E-05 0 0 0.012638 0.008129 0.005771 0.035638 0 0 0.000422 3.16E-11

Wiley-Blackwell and Society for Applied Microbiology Page 131 of 848

MycoplasmaHeliobacterium pulmonisMethanosphaerula strain modesticaldum UAB PelagibacterCTIP-01 palustris straindeep-sea ubique Ice1-30 strain HTCC1062-01eubacteriumRickettsia E1-9c-01 bellii ClostridiumSS9-08 strain OSUStaphylococcus difficile 85-389-01 strainLegionella R20291-08 lugdunensis pneumophila strain HKU09-01-01 str. Paris-01 0 0 0.004978 19.01841 0.045697 0 0 0 0.013028 0 0.1331 0 58.54319 0.027963 0.001827 0 0 0.002995 0 0.009091 4.57E-06 67.83211 0.01627 0 0 0 0.001795 0 0 1.04E-06 63.71087 0.052453 0 0.000136 0 0 0 0 7.05E-05 61.08091 0.0095 0 0 0 0.004477 1.03E-06 0.122483 0.001605 52.78812 0.084072 0.002247 0.002664 5.74E-05 0 0 1.16E-09 1.62E-05 56.46039 0.029754 0.005198 0 0 0.006302 0 0 0.000114 52.42548 0.047579 0.006561 0 0 0.006572 0 For0 4.13E-09 Peer63.91761 0.024766Review0.005297 Only0 0 0.004056 0 1.90E-07 0.000197 61.10016 0.052662 0 4.98E-10 0.000164 0.00153 0.0023 0.07148 0.00087 63.68362 0.06776 0 0 7.98E-05 0.004643 0 0.001858 3.33E-05 58.8138 0.07394 0 0.004217 8.93E-06 0 0 0 5.55E-05 50.33857 0.081522 0 0.009289 0 0.006478 0 0 0.00089 54.54881 0.007606 0 0 0.000342 0.005771 0 0.000446 0.001827 43.7355 0.028181 0.006062 0 0.000352 0.00577 0 0.011782 4.33E-05 64.34495 0.017002 0.007775 0.002198 0.000246 0 0.000121 0.020631 0.001467 48.40238 0.033962 0.002949 0 0.00013 0 0 0 6.86E-05 76.00937 0.040198 0.002773 0.000139 0 0.001056 0 0.017076 1.15E-06 53.40166 0.075444 0.005447 0.002168 7.91E-11 0.004111

Wiley-Blackwell and Society for Applied Microbiology Page 132 of 848

Escherichia Clostridiumcoli 55989-30Bacillus kluyveri pumilus strainSphingomonas DSM strain 555-08 HelicobacterSAFR-032-08 wittichiiRickettsia strainpylori RW1-08strain belliiMethanococcus 26695-08 strain RML369-C-08Pseudomonas jannaschiiPhotorhabdus fluorescens DSM 2661-01 asymbiotica str. SBW25-08 Fischer-Le Saux et al. 1999 emend. Akhurst et al. 2004-30 0 0 0.00522 0.051703 0 0 0.00785 0.028886 2.53E-05 0 0 0 0.016387 0 0 0 0.096805 0.009095 0 0 0.000203 0.019476 0 0 0.000101 0.022757 0 0 0 1.50E-14 0.020133 0 0 0 0.057616 0.00615 0 0 0 0.005383 0 0.004691 0 0.023054 0.005373 0 0 0.00535 0.007606 0 0.013022 5.54E-10 0.104894 0.016615 0 0 0 0.02697 0 0 0 0.026029 0.000431 0 0 0 0.025111 0 0 0 0.123114 0.096835 0 For0 0.000821 Peer0.013624 Review0 0.030191 Only0 0.017636 0.008151 0 0 0.000269 0.010239 0 0.008522 0 0.079637 0.016522 0 0 0.000158 0.016435 0 0.007415 0 0.113796 0.012388 0 0 0 0.028201 0 0 0 0.051938 0.041161 0.00366 0.000505 0.001629 0.021692 0 0.011129 0 0.151403 2.91E-05 0 0.003578 0 0.003713 0 0.040446 0 0.006996 0.013856 0 0.006615 0.004629 0.046862 0.009475 0 0.003679 0.033662 0 0.004657 0 0 0.006302 0 0 0 0.013 0.002009 0 0.000194 0.001756 0.021714 0 0 8.37E-06 0.031942 0.004288 0 1.27E-06 0 0.007747 0 0 0 0.037196 0.014049 0 0 0 0.011479 0 0.001394 0.001698 0.106506 0.024756

Wiley-Blackwell and Society for Applied Microbiology Page 133 of 848

ArthrobacterPyrobaculum chlorophenolicusPseudomonas islandicum strainLactobacillus strain stutzeriA6-01 DSM Bacillusstrain delbrueckii 4184-01 A1501-01 megateriumGluconacetobacter subsp. bulgaricusstrainHaemophilus DSM319-30 diazotrophicus strainSodalis parasuis ATCC glossinidius 11842-08 Dechloromonasstrain strain SH0165-01 PAl strain 5-08 'morsitans'-01 sp. RCB-08 0.000624 0 0.024294 0.007615 0.004379 0.02069 0.000648 0.000193 0.081302 7.60E-07 0 0.007435 0 0 0.00256 0.001302 0 0.00592 0.000322 0 0.015639 0 0 0.005766 0.000316 0.000124 0.015178 1.96E-05 0 0.042421 0 0.001233 0.002127 0.007551 0.001943 0.010951 4.49E-05 0 0.013083 0 0 0.005763 0.006309 0.000795 0.009295 0.000403 0 0.043787 0 0 0.001171 0 0.001671 0.026802 2.58E-05 0 0.037004 0 0.002609 0.005177 0.005803 0 0.01856 0.001293 0 0.039404 0 0 0.00824 0.002568 0.000392 0.015872 5.56E-30 For0 0.013914 Peer0 0.000991Review0.002867 0.001986 Only0.001027 0.013565 0.000199 0 0.030609 0 0 0.005197 0.007017 0.000385 0.022286 0.000571 0 0.024598 0 0.043125 0.001761 0.007579 0.001104 0.02003 0.000316 0 0.030385 0 0 0.019832 0.005792 0 0.007735 5.09E-05 0 0.113251 0 0.000197 0.005054 0.013276 0.00221 0.051636 0.00014 0 0.013731 0 0.015567 0.000277 0.00247 0.00056 0.005827 0.000269 0 0.021194 0 0.002448 0.017792 0.00493 0.001087 0.037383 0.00047 0 0.010705 0 8.21E-05 0.002562 0.00095 0.000516 0.006358 2.01E-05 3.49E-12 0.035727 0.010323 0.002814 0.017735 0.003333 0.001561 0.017907 0.000433 0 0.005499 0 3.64E-07 0.002501 0.001107 5.36E-06 0.004607 0.000313 0 0.090973 0 0.008493 0.003158 0.007195 0.001916 0.037914

Wiley-Blackwell and Society for Applied Microbiology Page 134 of 848

HerpetosiphonStreptomyces aurantiacusBrucella scabies DSM suis 785-0187.22-30Herpetosiphon str. 1330-01Mycobacterium aurantiacusSalmonella aviumDSM 785-30 Corynebacteriumentericasubsp. paratuberculosis subsp.Sulcia enterica muellerikroppenstedtiiVerrucomicrobiae strainserovar SMDSEM-08 K-10-08 Schwarzengrundstrain DSM bacterium 44385-08 strain V4-08 CVM19633-01 0.006495 0.005052 0 0.116691 0.008862 0 0.008674 0 0.38069 0.00056 0 0 0.003139 7.55E-07 0 0.00077 0.112014 1.62E-08 0.001339 4.02E-06 0 0 0.000201 0.000247 0 0 4.27E-05 0.00122 0.002508 0 0.019953 0.000531 0.001143 0 0 3.33E-06 0.001529 0.004473 0.010438 0.006753 0.000513 0 0.000194 0.001764 0 4.09E-06 0 0 0 5.46E-05 0 0 0.076262 6.77E-06 0.003413 0.001982 0 0.026055 0.001792 0.000369 0 0 0.060974 0.001509 2.48E-06 0 0.072699 0.002379 0.000116 0 0 7.80E-10 0.001401 0.00378For0.001285 Peer0.009791 0.000328Review0 0.001756 Only 0 0.002161 0.001436 0.005254 0 0.019154 0.000311 0 3.41E-06 0.076872 0.000728 0.000503 0.001085 0 0.197202 2.99E-07 0 0.001263 0 0.000266 0.002374 0 0 0 0 0 0 0 0 0.000584 0.009857 0.010188 0.014602 0.004231 0.001807 7.10E-08 0.051284 0.001913 0.001474 0 0 0.035083 0 0 0 0.062221 1.37E-12 0.004394 0.007293 0 0.025062 4.10E-05 0.000894 0 0 0.087284 0.00101 0.001433 0 0.016798 0 0 0.000824 0 0.013794 0.003394 0.000746 0 0.014348 0.000311 0 0.003269 0 0.094744 4.70E-05 0 0 0.021771 0 0 0 0 0 0.000972 0.003501 0.004373 0.012734 0.000589 0 0.000708 0 0.006732

Wiley-Blackwell and Society for Applied Microbiology Page 135 of 848

Sodalis glossinidiusNovosphingobium strainSalmonella 'morsitans'-30 aromaticivorans Chloroflexusenterica subsp.Sebaldella aurantiacusstrain enterica DSM termitidisLeptotrichia 12444-01 serovarstrain J-10-fl-08 strainParatypiBartonella buccalis ATCC A strainstr. 33386-08tribocorumRhizobium ATCC C-1013-b-01 9150-30 etliNeisseriastrain strain CIP gonorrhoeaeCIAT105476-01 652-01 strain FA 1090-01 0 0.033081 0 0.032395 0.00167 0.000156 0.008793 0.008538 9.31E-05 1.02E-07 0.000917 0 0 0.006747 0 0.000155 0.000709 0.000396 0.007569 0.00094 0 0.001165 0 3.87E-09 0.001084 0.004439 0.000736 0.008272 0.004772 0 0 5.16E-09 0 8.81E-05 0.003432 0 0.001486 0.005474 0 0 2.11E-09 7.89E-08 0.003801 0.001525 0.002051 0 0.003159 0 0.005945 0 3.85E-05 0.002807 0.002939 0 0.000722 0.012194 0 0 0.000186 0.001307 0.006421 0.000499 0 0 0.004229 0.001067 0.005269 0.00156 0.000138 0.004824 0.004877 0 0 0.005854For Peer0 0 Review0 7.74E-05 0.004315 Only0.002697 0 0.005363 0.004864 0 0 0.002122 2.32E-05 0.00133 0.003916 0 0 0.005842 0 0.001455 0 4.43E-05 0.001341 0.003808 0 0.029488 0.00719 0 0 0 7.90E-05 0.002847 0.00067 0.002926 0.002715 0.006528 0 1.21E-10 2.24E-07 8.38E-07 0.000769 0.004821 0.003422 0 0.008619 0 0.003314 0.003209 0.001292 0.004814 0.004093 0.000925 0.000152 0.004857 0 0 0 0.002762 0.002582 0.005518 0 0.003668 0.004609 0 0.000789 0.003848 0.001073 0.003178 0.002598 0.001449 8.97E-13 0.003673 0 0 0.001439 7.91E-05 0.002911 0.000938 0.003046 0.001434 0.001354 0 0 0.001113 9.84E-11 0.000579 0.0011 0 0.009075 0.003836 0 0 8.58E-06 0 0.002107 0.005547 0

Wiley-Blackwell and Society for Applied Microbiology Page 136 of 848

Bacillus sp. VibrioKSM-K16-01 choleraeNatranaerobius strain M66-2-30Caulobacter thermophilusMicrococcus crescentus strainEscherichia strainluteus JW/NM-WN-LF-01 NA1000-30 ATCC Acidovoraxcoli 9341-08 IAI39-01 Lactobacilluscitrulli strainColwellia sakeiAAC00-1-01 subsp. sp. 34H-08 sakei strain 23K-30 0.00303 0 0.00383 0 0.012168 0.000751 0.005415 0 0.453241 1.79E-10 0 0 0.00394 5.61E-05 0.000244 0.00089 0 0.429303 0 0 0 0.025708 0.001637 0 0.000354 0 0.113696 3.89E-10 0 0 0 0 0 0.003291 0 0.574726 2.32E-06 0 0.000356 0.043207 0.001146 0 0.00153 0 0.258014 6.55E-05 0 7.44E-07 0 0.000277 0 0.001318 0 0.602738 0.001125 0 0.00232 0 0 0 0.001017 0 0.264221 0 0 7.21E-07 0 0 0 0.00217 0 0.491688 2.83E-05 For0 1.09E-05 Peer0 0.004873Review0 0.001986 Only 0 0.60669 4.84E-06 0 5.72E-18 1.97E-17 7.12E-06 0 0.001166 0 0.374673 0.000417 0 0.000541 0.000108 6.64E-11 0 0.001237 0 0.51169 5.49E-05 0 0.000799 0 0.018658 0 0.002017 0 0.927692 3.74E-12 0 1.31E-06 0.055965 0.001476 0 0.002157 0 0.655043 7.81E-05 0 0.000512 0.005346 0 9.08E-05 0.001762 0 0.04516 0.001322 0 8.06E-05 0 0.002351 0 0.001262 0 0.501537 0.00051 0 0.000732 0.003054 6.18E-20 0 0.000774 0 0.230635 0.002268 0 0.001366 0 0.00601 0 0.002147 0.007139 0.451247 7.55E-07 0 9.15E-05 0 0.000601 0 0.000833 0 0.777381 5.08E-07 0.021865 0.000967 0 0.005438 0 0.00503 0 0.458518

Wiley-Blackwell and Society for Applied Microbiology Page 137 of 848

Silicibacter Tropherymasp. TM1040-30Lactobacillus whipplei strainParvibaculum fermentum Twist-01Acholeplasma strainlavamentivorans IFOPseudomonas 3956-01 laidlawii strainStenotrophomonas strain sp. DS-1-01 LB400-01PG-8A-08Tropheryma maltophiliaRhodococcus whipplei strain strain opacus K279a-01 Twist-30 strain B4-30 0.174014 0 5.58E-23 0.12569 0 0.003994 0.005254 0 0.05871 0.67083 0 0 0.013143 0 0.000686 0.000568 0 0.008985 0.916426 0 0 0.017065 0 0.000454 0.003637 0 0.000521 3.18438 0 9.53E-10 0.035675 0 0.000277 0.003005 0 0.013727 2.233556 0 0 0.030385 0 0.000255 0.001087 0 0.003143 0.727598 0 2.48E-07 0.020772 0 0.000493 0.001107 0 0.016917 0.452131 0 7.43E-09 0.06857 0 0.002349 0.002224 0 0 1.236288 0 0.000214 0.031928 0 0.001737 0.002518 0 0 0.580957 For0 Peer0 0.067332 Review0 0.000667 0.001416 Only 0 0.000106 1.220142 0 0 0.012523 0 0.001447 0.000791 0 0 1.309092 0 0.000115 0.026815 0 0.001508 0.001448 0 0.001107 0.661031 0 0 0.040141 0 0.000335 0.00139 0 0.00151 0.845139 0 0 0.024015 0.00467 0.002583 0.004269 0 0.002196 0.229827 0 0.000154 0.05629 0 0.000329 0.000935 0 0 0.36763 0 0.001 0.04673 0 0.001367 0.004688 0 0.011134 0.621261 0 0 0.054286 0 0.000492 0.001026 0 9.32E-10 0.345534 7.03E-06 3.81E-08 0.047226 8.35E-16 0.000778 0.005192 0.008208 0.003828 1.633859 0 0 0.014136 0 0.000192 0.000736 0 7.29E-05 1.049593 0 0.000318 0.024143 0.002945 0.001305 0.003508 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 138 of 848

Xylella fastidiosaAnaplasma 9a5c-30 Archaeoglobusmarginale strainFrankia fulgidus Florida-08 sp. AciduliprofundumCcI3-30 strain VC-16-08Gramella boonei forsetiiGeobacillus strain strain T469-30Gluconacetobacter kaustophilusKT0803-01Nitrosomonas HTA426-30 diazotrophicus europaea strain str. ATCC PAl 5-30 19718-08 0 0 0.019924 0.003579 0.300314 0.125436 0 9.36E-07 0.072518 0.150231 0 0 0 0 0.177988 0 0 0 0.084621 0 0 5.72E-08 0 0.246704 0 0.002684 0.017977 0.235236 0 0 0.0016 0 0.442468 0 0 0.008145 0.023724 0 0 0 0 0.262512 0 0.000907 0.004788 0.161946 0 0 0.000265 0 0.638896 0.049649 0.047565 0 0.073866 0 3.95E-14 0 0.062201 0.244541 0 0.003045 0.044426 0.398308 0 2.30E-05 6.31E-07 0 0.816224 0 2.37E-07 0.035414 0.045767 For0 Peer0 5.76E-07 Review0 0.193638 Only0 0.000232 0 0.170181 0 0 0.000279 0 0.374701 0 7.66E-05 0.010868 0.172254 0 0 1.73E-05 0 0.404101 0 0.00165 0.018917 0.254356 0 0 0.001035 0 0.414555 0 0.002979 0.022956 0.038249 0 0 0.000244 0.025065 0.856387 0.006952 0.000255 0.021052 0.060939 0 0.002395 0.001193 0.10926 0.233847 0 0.006988 0.008515 0.069566 0 0.017112 0.021173 0.011973 0.188319 0.01698 0.013938 0 0.096539 0.011636 0.000657 0.007172 0.024334 0.095916 0 0.007781 0.007357 0.01129 0 0.000917 0.006803 0.002762 0.309615 0.000636 0.006975 0.067673 0.054343 0 1.70E-06 0.027089 0 0.185212 0 1.32E-08 0.009984 0.082099 0 0 0.029808 0 0.852937 0.001399 0.002727 0.017893

Wiley-Blackwell and Society for Applied Microbiology Page 139 of 848

Serratia proteamaculansLegionella pneumophilaThermococcus strain 568-08Symbiobacterium str. sibiricus Lens-30Neorickettsia strain thermophilumMMLeptotrichia 739-08 sennetsu strainPolynucleobacter str.buccalis Miyayama-30 IAM strain 14863-08Synechococcus C-1013-b-30 necessariusStreptococcus sp. subsp.strain RF-1-30necessariuspneumoniae strain strain STIR1-08 P1031-01 0.003123 0 0 0.027312 0 0 0.018684 0 0 0.017576 0 0.03776 0 0 0 0 0.74413 0 0.008046 0.000895 0 0 0 0 0.011538 0.017892 0 0.017413 0 0 0.000142 0 0 0.013422 0 0 0 0 0 0 0 0 0 0.013316 0 0.022038 0 0 0.000192 0 0 0 0.078361 0 0.006291 0 4.52E-11 0 0 0 0.013747 0.027196 0 0.021118 0 0 0.004729 0 0 0.019279 0.196637 0 0.005457 0.023937For0.000255 Peer0.000793 Review0 0.002641 0.005209 Only0.020706 0 0.022434 0 0 0.003824 0 0 0.012761 0.156691 0 0.028636 0 0 0 0 0 0.017639 0.085302 0.000459 0.024931 0 0 0.000615 0 0 0 0.03254 0 0.033329 0 0 0.000221 0 0 0.016954 0.10102 0 0.00062 0 7.87E-05 7.71E-05 0 0 0.006948 0.031311 0 0.021232 0.045132 2.38E-08 0.01079 1.00E-08 0 0 0.005603 0 0.004532 0 0.004633 5.89E-08 0 0 0.023953 0 0 0.005366 0.010456 0.002138 0.006194 0 4.34E-07 0.006864 0.02868 0 0.012396 0.011185 0 0 0 0 0 0.053916 0 0.031034 0.009769 0 0.002237 0 0 0.027771 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 140 of 848

ThermococcusPseudomonas sibiricusRickettsia strain syringae MM belliiBorrelia 739-01pv. straintomato turicatae OSUAcidaminococcus str. 85-389-08 DC3000-01 strainYersinia 91E135-08 fermentans pestisYersinia strain strain pestis Antiqua-08Rhodopseudomonas DSM strain 20731-01 Antiqua-01Bradyrhizobium palustris sp. strain BTAi1-01 BisB5-30 0.000343 0.005158 0.100283 0 0.008767 0 0 0.248626 0.007911 0 0.001139 0.069252 0 0 0.010216 0.000156 7.46E-13 0.000691 1.19E-05 0.004854 0.002049 0 0.003899 0 0 0.001051 0.002193 0 0.008927 0 0 0 0 0 0.019119 0.005061 0 0.004475 0 0.002321 0.002348 0.009275 0 0.018086 0.002515 1.24E-05 0.007739 0 0 0.002506 0.012416 0 9.21E-27 0.003112 3.81E-13 0.009831 0.016597 0 0.002885 0 0 0.011872 0.003879 2.12E-11 0.008464 0.050476 0 0.000397 0 0 0.006904 0.00646 0 0.002731For Peer0 0 1.02E-11Review0 0.000441 Only0.011327 0.003476 2.25E-15 0.005744 0 0 0.002831 0 0 0.056863 0.001242 6.22E-05 0.005235 0 0 0.004484 0 0.000685 0.002435 0.002364 0 0.00455 0 0 0 0.011063 0 0.001835 0.001185 0 0.020044 0.011028 0 0.004433 0 0 3.27E-21 0.004295 0 0.001757 0 0 0.000515 0 0 0.005259 0.004487 9.10E-05 0.006168 0 0 0.002243 0.017157 0 0.036811 0.003217 0 0.001457 0.006366 0 0.000963 0.005412 0 0.002314 0.002346 5.75E-05 0.006081 0.005898 0.005063 0.010452 0 0.002023 0.008861 0.002538 0 0.001585 0 0 0.00268 0.015813 0.000174 0.003946 0.000972 0 0.020376 0 0 0.004084 0 0 0.000102 0.00397

Wiley-Blackwell and Society for Applied Microbiology Page 141 of 848

StreptococcusPolynucleobacter pyogenesMyxococcus str. MGAS315-30 necessariusMyxococcus xanthus subsp. strainPelotomaculum xanthus necessarius DK 1622-01 strainFrancisella strain DKthermopropionicum 1622-08 STIR1-01 tularensisLeptospira subsp. interrogansAcinetobacter strain mediasiatica SI-08Synechocystis serovar baumannii strain Lai str. FSC147-30sp.PCC6803-30strain 56601-08 AYE-08 0 0.004309 0.009831 0.025401 0.038717 0 0.034217 0.024803 0.011928 0 0.001648 1.75E-08 1.38E-18 0 0 0 0 0.541893 0 0.000873 0.000369 0.005216 0 0 0.002199 0.026307 0.024201 0 0.00264 3.19E-13 0 0 0 0.001512 0 0 0 0.003523 7.47E-06 0.001373 0 0 0.001787 0 0.011463 0 0.004828 0.000333 0.002869 0 0 0.012902 0 0.028333 0 0.006428 0.001357 0.003034 0 0 0 0.01494 0.100873 0 0.006038 0.000622 0.005749 0 0.238747 0.005157 0 0.148791 0 0.004076For2.59E-05 Peer0.001597 0.003812Review0 0.000551 Only 0 0.023631 0 0.002067 2.39E-12 0.003026 0.000688 0.132104 0 0 0.090568 0 0.006366 0.000446 0.002086 0 0.058283 0.00998 0 0.042037 0 0.003469 0.000559 0 0 0 0.000162 0 0 0 0.00809 6.48E-05 0.001613 0.001229 0 0.001583 0 0.124325 0 0.003352 5.67E-05 9.66E-08 0.004759 0.024187 0.00445 0 0.008446 0 0.004711 0.000376 0.019918 0.029333 0 0.010599 0 0.005236 0 0.002021 6.64E-05 0.002355 0.000268 0 0.000776 0 0.026396 8.44E-19 0.012775 0.001045 0.012855 0.015103 0 0.012336 0 0.009582 0 0.001695 0.000246 0.000169 0 0 0 0 0.09591 0 0.008026 1.57E-05 0.001254 5.72E-05 0 0.003623 0 0.100683

Wiley-Blackwell and Society for Applied Microbiology Page 142 of 848

SynechococcusGeobacillus sp. OS-typeBurkholderia sp. Y412MC10-30 A strainSalmonella JA-3-3Ab-08cenocepacia Leptospiraenterica strain subsp. MC0-3-08 interrogansChlorobium entericaStreptococcus serovarchlorochromatii serovar Copenhageni ParatyphiAcidovorax suis strain str. B strain WautersiaP1/7-08sp. CaD3-01 JS42-01 FiocruzSPB7-01 metallidurans L1-130-30 CH34-30 0.007047 0 0.004614 0.00021 1.42E-07 0.026337 0 0.004055 0.059388 0.07814 0 0.005921 0 0 3.65E-06 0 0.00079 0.151041 0.022669 0 0.001441 0.000329 0.011633 0.001163 0 0.001077 0.013578 0.006419 0 0.003907 0 0 0.001223 0 0.000625 0.065432 0.00468 0 0.002778 0 0 0.00085 0 0.001506 0.014312 0.006568 0 0.002829 0 0.025603 0.002078 0 0.001583 0.110805 0.019111 0.003559 0.00258 0 0.039971 0.001871 0 0.002492 0.041341 0.06888 0 0.007801 0 0 0.005095 0 0.002429 0.010241 0 For0 9.55E-06 Peer0.000179 Review0 0.00239 Only0 0.001295 0.004132 0.010789 0 0.003467 0.000837 0 0.000696 0 0.002361 0.008478 0.007676 0 0.003286 0 0 0.001466 0.004907 0.003328 0.072422 0.0252 0 0.002013 0 0 0.003164 0 0.001212 0.027975 0.016199 0 0.006879 0 0 0.003884 0 0.002254 0.035697 0.018167 0.007792 0.00094 8.70E-05 0 0.001465 0 0.000755 0.013151 8.09E-05 0.003056 0.001933 0 0 0.005192 0 0.003314 0.005972 0.004524 1.52E-14 0.002177 0.000242 0.003843 0.001955 0 0.000637 0.001046 0.007305 0.000694 0.002757 0 0 0.005717 0 0 0.023217 0.005192 0 0.001474 0 0.000859 0.000796 0 0.001505 0.003076 0.013245 0 0.00947 0 0 0.002112 0 0.002035 0.016522

Wiley-Blackwell and Society for Applied Microbiology Page 143 of 848

Candidatus MarinobacterVesicomyosociusNeisseria hydrocarbonoclasticus okutanii meningitidisChloroflexus strain HA-08 Shigellastrain aurantiacus VT8-01 alpha14-30 boydiiMethylobacterium strain strain J-10-fl-30 CDCGeobacillus 3083-94-30 sp. CandidatusDM4-30 sp. Y412MC61-30 BurkholderiaAccumulibactor cepacia phosphatis AMMD-08 Type IIA str. UW-1-08 0.802517 0.247645 0 0 0.012085 0.001184 0 0.032214 0.005156 1.074609 0.017261 0 0.03896 0 0 0 0.018548 0.004971 1.206737 0.035891 0 0.007029 0 0.000507 0 0.008111 0.002245 0.740072 0.075662 0 0.000804 0.05977 0.010451 0 0.005318 0.007708 0.098173 0.045666 0 0.008714 0.005387 0.001388 0.000664 0.011137 0.002806 2.09367 0.100322 0 0 0.336909 0.010425 0 0.032804 0.006997 2.817386 0.070112 0.049423 0.008242 0 0.013878 0 0.033039 0.003496 3.049926 0.069101 0 0 0.155261 0 0 0.045235 0.0032 0.622692 0.042824For0.04208 Peer0 0.005613Review0.002253 Only0 0.005474 0.000275 2.167326 0.058257 0 0 0 0.007961 0 0.010428 0.005891 3.371941 0.045604 0 0 0 2.09E-06 0 0.017444 0.005387 0.25427 0.071998 0 0 0 0.003065 0 0.009643 0.004558 0.860692 0.211531 0.010667 0 0 0.004869 0 0.025479 0.008496 0.378333 0.024556 0.004651 0 0.011384 0.001853 0 0.003861 0.000347 4.426891 0.057324 0 0.000802 0 0.006404 0 0.056008 0.002893 0.225208 0.024633 0.001351 0.011238 0 0.013743 2.22E-06 0.005323 0.001776 2.756808 0.069988 0 0 0.010016 0.006917 0 0.025369 0.005359 0.520099 0.016009 0 0 0 0.000227 0.007834 0.006571 0.003735 1.369353 0.177966 0.015175 0.000551 0.045991 0.000265 0.001343 0.015196 0.007383

Wiley-Blackwell and Society for Applied Microbiology Page 144 of 848

Buchnera sp.Desulfobacterium APS-01 Bacillus autotrophicum sp. ClostridiumKSM-K16-30 deep-seastrain novyi-NT-30 HRM2-30 eubacteriumuncultured ShewanellamethanogenicSS9-30 Bacteroides putrefaciens archaeonDSM thetaiotaomicron Ricestrain 13-30 Cluster CN-32-08 I-30 strain VPI-5482-08 0 0.001628 0.040507 0 0 0 0 0.00422 0 0.003188 0 0 0 0 0 0.016629 0.001856 0 0 0.001362 0 0 0.021978 0 0 0.011188 0 0 0 0.000429 0 0.153674 0 0.018545 0.010699 0 0 0.018081 0 0 0.006797 0 0.01126 0.014171 0.000602 0 0 0 0.048024 0.027348 0 0.047347 0.01023 0 0 4.45E-05 0.00366 0 0.026245 0.029082 0 0.003514 0 0 2.02E-10 0 0 0 0 0 0.019243 0 0.011676 0.001598For Peer0 0 Review0.0552 0 0.017136 Only0.004554 0 0 0.004163 0 0 0.015319 0 0.021888 0.006914 0 0.009849 0.038851 0 0 0.008591 0.069131 0.02407 0.014774 0 0 0.017493 0 0 0.117269 0 0.058366 0.010671 0 0.006818 3.67E-07 6.38E-05 0 0.046218 0 0.038666 0.004002 0 0 2.87E-05 0 0 0.000619 0.000887 0.014965 0.001367 0.002083 0 0.239282 0.000711 0 0.136044 0.012013 0.026654 0.003539 2.46E-05 0 0.00827 0 0 0.02583 1.75E-06 0.018088 0.002047 3.46E-06 0 0.015701 0.000449 0.008594 0.04571 0.00825 0.010814 0.006883 1.44E-06 0 0.025822 0 0 0.118267 0 0 0.005431 0 0 0.011331 0 0 0.034094 0 0.031552 0.004625 0

Wiley-Blackwell and Society for Applied Microbiology Page 145 of 848

MinibacteriumDesulfomicrobium massiliensis-08Xylella fastidiosa baculatumMycobacterium strain strainAcinetobacter M12-01 DSM tuberculosis 4028-01Coxiella baumannii strain burnetiiDesulfotomaculum H37Ra-30 strain strain ACICU-30Borrelia CbuG_Q212-01 reducensturicataeStaphylococcus strain MI-1-0891E135-30 aureus subsp. aureus strain ED98-30 0.138483 0.009947 0.004039 0 0 0.021829 0.021142 0 0.078683 0.021222 1.12E-05 5.29E-05 0 0 0 0.008903 0 0 0.020439 0.000647 0.00085 0 0.026956 0.006381 1.03E-11 0 0 0.021416 0.003824 0 0 0 0.005992 0 0 0 0.015499 0.001225 0.002459 0 0 0 0.000835 0 0 0.0237 0.0066 0.001489 0 0 0.020559 0.008634 0.008311 0 0.012503 0.005959 0.002155 0 0 0 0.007235 0 0 0.012555 0.005953 0.002593 0 0 0 0 0 0 0.008052 0.0041For0.0033 Peer0 Review0 0 4.72E-05 Only 0 0 0.015861 0.003163 0.000575 0 0.009377 0.00811 5.07E-14 0 0 0.018121 0.004567 0.001563 0 0 0 0.00116 0 0 0.005031 0.00114 0.001761 0 0.026706 0.005693 0 0 0 0.032681 0.00542 0.002924 0 0 0.014906 0 0 0 0.005722 0.003036 0.001947 0 0 0.006337 0.00099 0 0 0 0.0065 0.001331 0.001968 0 0 0.005042 0 0 0.012793 0.000785 0.000891 0 0 0 6.85E-05 0 0 0.011835 0.005505 0.003228 0.000485 0 0 0.000424 0 0 0.009745 0.001268 0.000162 0 0.003542 0 0 0 0 0.029091 0.010107 0.000719 0 0 0 0.001337 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 146 of 848

Ehrlichia chaffeensisDesulfovibrio str.Streptococcus Arkansas-01salexigensThermoanaerobacter strain mutans DSM Gluconobacterstrain 2638-08 NN2025-01 pseudethanolicusMethylobacterium oxydansEggerthella strain strain 621H-08sp. VibrioBJ001-08lenta ATCC strain salmonicida33223-01Methanospirillum DSM 2243-08 LFI1238-01 hungatei strain JF-1-30 0.000124 0.019616 0 0.016568 0.029179 0.010783 0.004544 0.000633 0.000467 2.18E-09 0.016288 0 0 0.014076 0.005919 0 0.000459 0 0.000269 0.020341 0 0 0.02194 0.005377 7.01E-13 0.002722 0 2.35E-20 0.004555 0 0 0.044352 0.003936 1.64E-06 0.00916 0 0 0.009342 0 0 0.077319 0.00288 3.53E-12 0.003477 0 0.00028 0.006265 1.55E-06 0.000149 0.007058 0.004194 0.00541 0.004748 0 0.001602 0.003815 0 0.001242 0.013848 0.016159 0.000431 0.005849 0 0.000341 0.008913 0 0.000496 0.008009 0.005647 4.39E-05 0.010518 0 0.004618 0.006944For Peer0 9.80E-05 0.008562Review0.004771 9.53E-13 Only0.002515 0 2.43E-05 0.000823 0 8.54E-05 0.008077 0.005021 0.001475 0.002692 0 0.002024 0.005133 0.00046 0.00024 0.009353 0.003701 0.0062 0.003887 0 0.003376 0.015097 0 0.001194 0.061592 0.0009 2.88E-06 0.003258 0 0.0003 0.003383 0 0 0.029161 0.00642 0.001244 0.023044 0 0.003788 0 0 0.000952 0.002074 0.003412 0 0.002706 0 0.012292 0.015968 0 0.005115 0.033331 0.017319 0 0.004136 0.00123 0.004254 0.003453 0 0 0.009822 0.003882 1.26E-33 0.00234 0 0.001453 0.022096 1.35E-23 0.00233 0.048886 0.015154 0.001005 0.006271 0.005372 0.000858 0.003522 2.03E-05 0.000188 0 0.001279 0.000186 0.00193 0 0.002629 0.010289 0 0 0.019956 0.001262 0.002648 0.00927 0

Wiley-Blackwell and Society for Applied Microbiology Page 147 of 848

SulfurospirillumEscherichia deleyianum Dehalococcoidescoli O55:H7 strainDesulfovibrio strainDSM sp.6946-01 CB9615-01 BAV1-08Hirschia magneticus balticaLeuconostoc strain strain RS-1-30 ATCCSyntrophobacter mesenteroides 49814-30Pelobacter subsp.fumaroxidans Hyperthermuscarbinolicus mesenteroides strain strain butylicusMPOB-30 strain DSM ATCC 2380-30strain 8293-01 DSM 5456-01 0.001421 0 0 0 0.062887 0 0.047239 0.150054 1.31E-14 0.000111 0.000128 0 0 0.002142 0 0 0 0 0.000475 0.000349 0 0.002096 0.013389 0 1.31E-29 0.013949 0 0.005173 0 0 0 0.024049 0 0 0.04055 0 0.000247 0 0 0.006602 0.038442 0 0.001612 4.66E-05 0 0.004588 0.001062 0 0 0.024557 2.54E-08 0.000926 0.033307 0 0.00281 0.001653 0 0 0.03009 0 0.029719 0.025146 0.001931 0.009454 0.000955 0 0 0 0.00039 0 0 0 0.00212 For0 Peer0 0.000608 Review0.0156 0 0.000795 Only0.002133 0 0.004807 0.001557 0 0 1.29E-05 0 0 0.033588 0 0.004661 0 0 0 0.011247 0.000466 0 0.126097 0 0.000986 0.000708 0 0 0.02847 0 6.98E-09 2.37E-07 0 0.002991 0 0 0 0.090906 0 1.15E-05 0.0367 0 0.002863 0.0005 0 0 0 0.000142 1.65E-05 0.017651 0 0.002381 0 0.018368 0.002969 0.030771 0.000374 0.021436 0.15799 6.38E-07 1.77E-08 0 0 2.14E-08 0.040333 0 0 0.019012 0 0.002599 0.001206 0.010087 0.006374 0.028756 0 0.034403 0.055205 0.00135 0.001496 0.000237 0 0 0.022804 0 0 0.046468 0 0.000259 0 0 0 0.083763 0 0.005669 0.002319 0

Wiley-Blackwell and Society for Applied Microbiology Page 148 of 848

HalorhodospiraRhodopseudomonas halophilaAmmonifex strain SL1-08palustrisgas degensii vacuolate strain strainFrancisella BisB18-08str. KC4-08 37-01 philomiragiaCandidatus SalinibacterBlochmannia subsp. philomiragiauncultured ruber pennsylvanicus strain strain Vibriomethanogenic DSM ATCC harveyi strain13855-01 25017-30 BPEN-01 strainarchaeon ATCC Rice BAA-1116-08 Cluster I-01 0.070652 0.054177 0.041394 0.015773 0 0 0.009621 0.006262 0.027101 0.071264 0.009167 0 0.0119 0 0 0.000312 0 0.066836 0.028895 0.014727 9.42E-06 0.019674 0.03851 0 0 0 0.020411 0.021353 0.006285 0 0.028974 0 0 0 0 0.021477 0.012033 0.013363 0 0.010907 0.043805 0 0.000383 0 0.013636 0.062381 0.008946 0 0.04299 0.089762 0 7.99E-05 0 0.06354 0.043855 0.019499 4.87E-09 0.025726 0 0.006683 0.000973 9.13E-06 0.020444 0.020948 0.017403 0 0.036562 0.474127 0 1.62E-05 0 0.046788 0.024956 0.00555For Peer0 0.011795 Review0 0 7.93E-08 Only 0 0.022157 0.056748 0.009555 0.003704 0.027686 0.179771 0.002774 0.000448 0 0.051542 0.065855 0.002566 0 0.029593 0.157362 0.003497 0.001883 0 0.055264 0.048373 0.010059 0.005469 0.015237 0.037791 0 0.000212 0 0.076498 0.078962 0.017757 0 0.058717 0.048278 0.003388 1.96E-07 0.00088 0.089606 0.012521 0.0031 0.000997 0.013745 0.012941 0.001978 4.98E-05 0.000335 0.005768 0.034073 0.018352 0.011426 0.029302 0 0 5.19E-05 0.000294 0.029443 0.024078 0.006004 0.002366 0.005444 0.049333 0.00025 0 0 0.01595 0.063034 0.019564 0.023411 0.033255 0.028182 0.003742 0.001292 0.001664 0.016805 0.013071 0.005069 0 0.008718 0 5.80E-05 4.38E-06 0 0.034505 0.11502 0.010422 0 0.063971 0.002073 0 0.00054 0 0.041264

Wiley-Blackwell and Society for Applied Microbiology Page 149 of 848

Citrobacter Thermodesulfovibriorodentium Bacillusstrain ICC168-01 cereus yellowstoniiEscherichia strain E33L-01 PediococcusDSMcoli O157:H7 11347-01Thermosynechococcus pentosaceus strain TW14359-01Haemophilus strain ATCCCandidatus elongatus influenzae 25745-08 strain XanthomonasRiesia strain BP-1-01 pediculicola 86-028NP-30 euvesicatoria USDA-01 str. 85-10-08 0.001039 0.023865 0.000455 0 0 0.007636 0 0 0.004291 8.50E-05 1.19E-06 0 1.39E-10 0 0.016217 0 0 0.005751 0.000835 0.00072 0 0 0 0.00713 0 0.002492 0.001368 0 0 0 0 0 0 0 0 0.007672 0.000457 0.000457 0 9.11E-05 0 0.002388 0 0.015161 0.002871 0.00164 1.13E-05 1.22E-05 0.000518 0 0.013049 0 0 0.008377 0.00108 0.003475 5.78E-05 0 0 0.00401 0.038144 0.001842 0.0037 0.001556 6.18E-07 0 0 0 0.00326 0.11603 0.003476 0.00441 0.001123 0.000485For6.62E-05 Peer0 0.008557Review0.002299 Only0 0.006418 0.001236 0.001116 0.001359 0 0 0 0.012303 0.00253 0 0.004665 0.000758 0.000755 2.95E-06 0 0 0.00574 0 0 0.007049 0.001333 0.001401 0 0 0 0.002509 0 0.005264 0.00158 0.002172 0.000953 0.00013 0.000643 0 0.001472 0.003282 0 0.011293 0 0.000754 0 8.51E-05 0 0.015014 0.037369 0.004862 0.000646 0.000687 0.00432 0 0 0 0.001977 0 0.00194 0.010584 0.000736 2.75E-05 4.94E-05 0 0 0.000431 0 0 0.000416 0.001543 0.004995 0.000119 0 0.000161 0.002481 0 0.003043 0.00647 0.000154 1.57E-06 0 0 0 9.52E-05 0.002979 0.000725 0.001311 0.004677 0.00338 2.51E-05 0 0 0.004601 0.009058 0.002659 0.008939

Wiley-Blackwell and Society for Applied Microbiology Page 150 of 848

PseudomonasSynechococcus fluorescensGeobacter strainsp. RCC307-08 Pf0-1-01 uraniumreducensProchlorococcusBrucella sp. Rf4-08 suisAS9601-08Rickettsia strain ATCC akariCampylobacter 23445-08 strain Hartford-30Fervidobacterium lari strainDesulfovibrio RM2100-01 nodosum salexigens strain Rt17-B1-01 strain DSM 2638-01 0.010593 0 0.034419 0.010901 0 0 0.001931 0.001033 0.011951 0.002368 0.052194 0.00146 0.016408 0 0 0 1.19E-07 0.001002 0.005757 0.012793 0.004508 0.003353 0.014957 0.034185 1.95E-13 2.61E-24 9.16E-06 0.010027 0 0.008382 0.009611 0.049053 0 0 0 0.00202 0.00457 0.016601 0.00251 0.001753 0 0 9.65E-08 0.001379 0.001316 0.013173 0.002149 0.007535 0.041009 0 0 0.001676 0.001179 0.001468 0.008061 0.001027 0.012421 0.003586 0 0 0.004011 0.001659 8.51E-05 0.010895 0.047407 0.005993 0.027573 0 0 0.000138 0 0.001026 0.003434 0.052506For0.008238 Peer0.011168 Review0 0 0.000503 Only2.55E-24 0.001646 0.007289 0.009655 0.005276 0.02245 0 0 2.98E-05 2.47E-19 0.000315 0.008113 0.002306 0.001989 0.003743 0 0.098924 0.002204 0.001267 0.001224 0.006938 0.004739 0.004498 0 0 0 2.08E-05 0.001612 0.002559 0.028265 0.002115 0.0087 0.018746 0 0.001049 0.000472 9.10E-10 1.89E-06 0.003743 0.101733 0.00452 0.021844 0 2.88E-13 0.001278 0 4.60E-05 0.00634 0 0.027141 0.003988 0 0 0.000228 0.002156 0.001329 0.004874 0.096179 0.006282 0.029585 0.009352 0 7.61E-05 0.001038 0.00054 0.010297 0.002208 0.022697 0.003065 0.049531 0.015978 0.002575 0.002076 0.0041 0.001723 0.001259 4.61E-05 0.00637 0 0 3.37E-08 1.66E-10 0.001192 0.024602 0.015237 0.006301 0.014881 0 0 1.79E-06 0 0.00162

Wiley-Blackwell and Society for Applied Microbiology Page 151 of 848

Listeria welshimeriCaulobacter serovarSynechococcus segnis 6b strainHalothermothrix SLCC5334-01ATCC sp. OS-type 21756-08Salmonella A orenii strain Cryptobacteriumenterica strain JA-3-3Ab-30 H subsp.168-08Candidatus enterica curtum EscherichiaAzobacteroides serovarstrain DSM Enteritidis Streptosporangiumcoli 15641-08 strain pseudotrichonymphae strain ATCC P125109-308739-01 roseum straingenomovar. DSM 43021-08 CFP2-30 0 0.029593 0.001587 0.077738 0 9.31E-06 0 0.000111 0.02168 0 0.000797 0.453639 1.97E-15 0 0 0 0 0.00244 7.26E-06 0.016559 0.027903 4.10E-06 0 0 0 0 0.001908 0 0.009954 0.017889 0 0 0 0 0.000166 9.03E-06 0 0.010371 0.016596 0 0 0 0 0 4.12E-05 0.001146 0.009824 0.250743 2.80E-26 0.042194 1.98E-14 0 1.19E-15 9.54E-06 0 0.012852 0.010101 0.008308 0 0 0.006558 0 0.001294 0 0.008236 0.03645 0.001923 0 0 0 0 8.91E-06 0 0.003263For0.020574 Peer2.39E-08 Review0 0.006965 Only0 0 0.001044 0 0.010228 0.081047 0.004322 0 0 0 0 0.002338 0 0.009074 0.196399 0.003419 0 0 0 7.88E-05 0.000809 0.000403 0.011815 0.084748 0 0 0 0 0 2.10E-06 0 0.01072 0.130397 0.000341 0 0 0 0 7.65E-05 0 0.005574 0.068774 0.00439 0 0 0 0 0.00043 0 0.006589 0.078244 0.000248 0.00276 0 0 0 0.008486 4.41E-06 0.007569 0.066774 0.005909 0 0 0 0.00017 0.00391 0.000207 0.018058 0.008686 0.000752 0 0.001958 0.046409 0 0.007115 0 0.008794 0.16867 0 0 1.58E-11 0 0 8.17E-06 0.00023 0.017275 0.026458 0.003872 0 0 0 0 0.00023

Wiley-Blackwell and Society for Applied Microbiology Page 152 of 848

ClostridiumVibrio perfringens fischeriStreptococcus strain strain ATCC MJ11-30Halothermothrix 13124-30 pneumoniaeBordetella TIGR4-08 orenii bronchisepticaBurkholderia strain H 168-30Rubrobacter sp. RB50-08 PsJN-01Pseudomonas xylanophilusHelicobacter entomophilastrain DSM pylori 9941-01 strain strain L48-01 P12-01 0 0.010969 0 0 0.013439 0.003094 0.032788 0.004193 0 0 0.487833 0 0 5.58E-05 0.000722 1.48E-13 0.001061 0 0 0 0 0 0.002829 0.001653 0.001722 0.003858 0 0 0 0.007529 0 0.005444 0.001994 0.002796 0.018718 9.55E-08 0 0.046748 0 0 0.003459 0.000742 0.000877 0.005579 0 0 0 0 0 0.002472 0.002219 0.001922 0.014919 0 0 0.116711 0 0 0.00501 0.003594 0.003002 0.009214 0 0 0.110075 0 0 0.002929 0.001638 0.001097 0.011642 0 0 For0 Peer0 0 0.002049Review0.001041 0.00171 Only0.005478 0 0 0.088901 0 0 0.003344 0.002014 0.000973 0.009481 0 0.031922 0.10977 0 0 0.004835 0.003055 0.001127 0.006113 0 0 0 0 0 0.001025 0.000955 0.000872 0.007893 0 0 0.063986 0 0 0.009589 0.000337 0.001194 0.031165 0 0.000689 0 0 0 0.000304 0.001071 0.003577 0.002012 0 0.002123 0.113637 0 0.01526 0.009117 0.003429 0.004706 0.005804 0 0 0.070917 0 0 0.00158 0.001221 0.000194 0.002724 0 0 0.023478 0 0.007578 0.0089 0.00229 0.004975 0.00996 1.40E-05 0 0.057126 0 0 0.002086 0.000764 1.96E-12 0.001828 0 0 0 0 0 0.008825 0.002195 0.00092 0.029759 0

Wiley-Blackwell and Society for Applied Microbiology Page 153 of 848

ProchlorococcusErwinia marinus amylovoraPhenylobacterium str. MIT strain Pyrobaculum9301-08 CFBP1430-01 zucineumFusobacterium aerophilum strainLysinibacillus HLK1-08 strain nucleatum IM2-30Elusimicrobium sphaericus subsp. nucleatumSalmonella strain minutum C3-41-08 str. Thermococcusenterica strainATCC subsp.25586-01Pei191-08 kodakarensis enterica serovar strain Choleraesuis KOD1-30 strain SC-B67-01 0.008372 0.000489 0.053402 0 2.84E-05 0.012831 0.015311 0 0 0.038694 0 0.006998 0 0 0 0 0 0 0.003168 0.000956 0.015945 0 0 0.0072 0.000314 0 0 0.009774 0 0.008072 0 0 0 0 0 0 0 0 0.008396 0 6.57E-05 0.002712 0 0 0 0.008221 0 0.009987 0.080119 0.001192 0.02698 0.003443 0 0 0.002882 0 0.028261 0 0.001456 0.00084 0 0 0 0 0.003195 0.021949 0 3.18E-11 0.018496 0 0 0 0.011866 For0 0.010292 Peer0 5.44E-06Review0.00166 Only0 0 0 0.012699 0 0.019562 0 2.78E-15 0.000311 0.007143 0 0 0.002372 0 0.010169 0 6.20E-05 0.002613 0 0 0 0.005834 0 0.008794 0 0 0 0 0 0 0.010218 0.002756 0.019616 0 0.000437 0 0.000412 0 0 0.022499 0 0.006669 0 0.001285 0.005977 0 0 0.010186 0.001106 0 0.037607 0.023484 0.001422 0.001038 0 0 0 0.016112 0 0.011966 0 0 0.002033 0.001103 0.000204 0 0.001716 0 0.028297 0 1.81E-06 0.005086 0.001046 0.000927 1.55E-10 0.001946 0 0.003334 0 4.04E-05 0 0.006467 1.23E-05 0 0.006667 0.003741 0.012575 0 4.85E-06 0.005866 0.013489 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 154 of 848

Rhizobium etliBordetella strain CFN petriiBifidobacterium 42-01 strainAlcanivorax DSM adolescentis12804-30Streptococcus borkumensis strainSyntrophobacter ATCC strainpneumoniae 15703-01 SK2-08Mycobacterium strain fumaroxidans EscherichiaATCC sp. 700669-01 KMS-30 strain Zunongwangiacoli MPOB-01UMN026-30 profunda strain SM-A87-08 0.006477 0.006288 0 0.567435 0 0.010017 2.34E-14 0 0.136239 0.000938 0.030592 0 0.556991 0 2.93E-18 0.069988 0 1.90747 0.001751 0.012422 0 0.278054 0 0.000148 2.41E-05 0 1.181433 0.001361 0.002211 0 0.411913 0 1.45E-12 0.010135 0 0.973821 0.001755 0.012005 1.97E-10 0.167787 0 3.87E-06 0.0036 0 0.9506 0.004531 0.000126 0 0.653516 0 0.000149 0 0 1.579943 0.005281 0.009587 0 0.258509 0 0.000111 0 0 0.51817 0.005443 0.086315 0 0.690913 0 0.000143 0 0 2.221395 0.002543 0.019703For Peer0 0.180256 Review0 9.98E-06 0.003014 Only 0 0.545922 0.001991 0 0 0.547045 0 0.000145 0 0 2.001133 0.003126 0.012324 0 0.658237 0 0.002445 0 0 1.277166 0.00179 0.01559 0.001342 0.517952 0 1.29E-09 0 0 1.489131 0.002059 3.25E-15 0 0.942777 0 0.000405 0 0 1.489012 0.003019 0.001978 8.06E-05 0.086041 6.39E-05 0.000223 0 0 0.181274 0.002624 0.010935 0 0.341235 0 0.000719 0 0 0.55729 0.00247 0.014209 0.000392 0.181847 0 2.72E-07 0 0.00166 0.143708 0.005471 0.02011 1.97E-08 0.316256 0 0.001347 0.004626 0 0.349914 0.001555 0.027461 0 0.266056 0.000135 0.000104 0 0 0.915868 0.00973 0.004658 0 0.66212 0 0.00063 0 0.007849 1.216148

Wiley-Blackwell and Society for Applied Microbiology Page 155 of 848

SynechococcusAtopobium sp. RF-2-01Salmonella parvulum strain Anaplasmaparatyphi DSM C20469-01 Fusobacteriummarginale strain RKS4594-30 strainSpirosoma nucleatum Florida-30 lingualePyrococcus subsp. strain nucleatum Streptococcussp. DSM OT3-08 74-01 str.Lactobacillus gordoniiATCC 25586-30 str. reuteri Challis strain substr. JCM V288-30 1112-30 0.005557 0 0 4.39E-07 0 0.01146 0.013988 0 0 0 0.001546 0 2.89E-07 0 0.002958 0 0 0 0.000901 0 0 0.02516 0 0.006384 0 0 0 7.34E-09 1.85E-06 0 0 0 0.003493 0 0 0 0 0 0 0 0 0.005355 0 0 1.97E-06 0 0 0 0 0 0.006641 0 0 0 0.000673 0 0 6.98E-06 0 0.005846 0 0 0 0 0 0 1.21781 0 0.010709 0 0 0 0.000388 For0 Peer0 0.006211 0.000118Review0.00221 Only0 0 0 0.001789 0 0 0.045198 0 0.005028 6.75E-10 0 0 0 0.003554 0 0 0 0.016171 6.99E-10 0 0 0.000625 0 0 0 0 0.004215 0 0 0 0 6.67E-06 0 0.08298 0 0.010812 0 0 0 0.00097 0.000207 6.26E-15 0 0 0.005191 0.003393 0 0 0.001113 0 0 0.068924 0.026068 0.003832 8.94E-08 0 0 1.88E-05 5.48E-06 0.001767 0.031182 0 0.001216 0.001724 0.006977 0 0.002283 0.000168 0 2.09E-14 0 0.008908 0.00163 0 0 0.000148 0 0 0 0 0.001212 0 0 0 0.000812 7.34E-05 0 0 0 0.005796 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 156 of 848

Rickettsia felisCandidatus strain URRWXCal2-08 RhodopseudomonasVesicomyosociusgas vacuolate okutanii palustrisXanthomonas str. strain 37-30 strain HA-30Bordetella CGA009-30campestris bronchisepticaDehalococcoides pv. campestrisCandidatus RB50-01 sp. strain GT-01 SalmonellaBlochmannia 8004-08 enterica pennsylvanicus subsp. enterica strain serovarBPEN-30 Agona str. SL483-01 0 0.08227 0.052339 0.062637 0.010419 0.003571 0.012785 0 0 0 0 0 0.003428 0.004517 0.001036 0 0 3.95E-14 0.005235 0 0.000425 0.084697 0.001991 0.000785 0 0 0.000216 0 0.710635 0.002407 0.459494 0.002763 0.001604 0 0 0 4.05E-07 0 0.02066 0.130882 0.005185 0.001238 0 0 0 0 0 0 0.207673 0.006889 0.002054 0 0 0 0 0 0.014025 0.157399 0.006324 0.001994 0.001921 0 0 0.051902 0.49317 2.20E-05 0.216393 0.007617 0.001191 0 0 0.000584 0.010158 0.769025For0.009308 Peer0.209961 Review0 0.002414 Only0 0 0 0.008007 0 0.015509 0.065935 0.00348 0.001012 0 0 0 0.005436 0 0.012545 0.198602 0.004649 0.002277 0 0 0.000875 0.008172 0 0.002783 0.706797 0.002438 0.000986 6.37E-06 0 0.001042 0.004046 0.888939 6.70E-08 0.105458 0.004986 0.003001 0 0 0 0.011833 0.365758 0.007801 0.039795 0.002346 0.002454 0 0 0.000511 0.017643 2.021258 0.043701 0.152518 0.003722 0.003099 0 0 0.001294 0.00415 0.111852 0.010184 0.248791 0.000818 0.000798 0 0 0 0 1.396144 0.011141 0.104574 0.003881 0.001174 0.001592 0.000873 0.000921 0.00553 0.080786 0.00385 0.293339 0.001114 0.000317 0 0 0 0.001898 0 0.000761 0.122258 0.00818 0.00199 0 0 0.00098

Wiley-Blackwell and Society for Applied Microbiology Page 157 of 848

Actinobacillusnot pleuropneumoniae OenococcusSulfolobus oeni MCW-08 islandicus Burkholderiaserovar 3 strainstr.Klebsiella ambifaria JL03-30 L.D.8.5-01 variicolaHalomicrobium strain MC40-6-01strainCorynebacterium At-22-30 mukohataeiGardnerella strain jeikeiumCaulobacter DSMvaginalis strain 12286-01 strainK411-08 sp. K31-01 409-05-08 0 2.12E-07 0 0.001687 0.000316 0.000307 0 0 0.005407 0.070085 0 0 5.18E-05 0 0 0 0.0016 0.000526 0 0 0 0.000128 0.007298 0 0 0 0.001165 0.07362 0 0 0.000397 0 0 0 0 0.000714 0.000151 0 0 0.000336 0 0 0.000121 0 0.004744 0 0 0 0.000762 0 0 0 0 0.002271 0 0 0 0.000164 1.73E-07 0 0.004251 0 0.00511 0 0 0 0 0 0.000237 0.003124 0 0.00364 0 For0 Peer0 0.000895 0.004103Review0 Only0 0 0.002504 0.211896 0 0 0.000273 0.015245 0 0 6.59E-05 0.000853 0.124878 0 0 0.000758 0.006483 0 0 0 0.002403 0 0 0 0.000713 0.032202 0 8.21E-06 0 0.001858 0 0 0 0.00105 0 0 0 0 0.002537 0.003884 0 0 0.000777 0 0 0 0 0.003368 0 0 0 0.000938 8.18E-06 1.06E-06 0.003287 0 0.001842 0.069705 0 0 0.00019 0 2.37E-05 0.006326 0 0.003075 0.02824 0.000283 6.02E-08 0.001852 0.000223 0 0.000806 0 0.002472 0.009486 0 0 0.000244 0.003569 0 0 0 0.00046 0.043169 0.007273 4.43E-07 0.00103 0 1.42E-06 0.000346 0 0.00018

Wiley-Blackwell and Society for Applied Microbiology Page 158 of 848

ShewanellaThermobaculum frigidimarinaSerratia strain terrenum proteamaculans NCIMBBordetella strain 400-08 ATCCparapertussisNeisseria strain BAA-798-08 568-01 meningitidisEhrlichia strain 12822-08ruminantium Burkholderiaserogroup B Salinibacterstrain strain pseudomallei Welgevonden-08 MC58-08Streptococcus ruber strain Anton 1710b-08 et pyogenes al. 2002-08 strain MGAS10750-01 0.027908 0.095505 0.000236 0.012816 0 0 0.000731 0.016223 0 0.082306 0 6.32E-05 0.000172 0 0 0.000543 0 0 0.01096 0.000905 0.000547 0.006158 0.001985 0 0.000706 0.000309 0 0.106795 0 0 0.003447 0 0 0.00092 5.99E-05 0 0.059134 0.004099 0.000623 0.002458 0.004219 0 0.002883 0.001238 0 0.181458 0.000211 0.005171 0.003351 0 0 0.002182 0.006819 0 0.025257 0.014022 0.001342 0.004965 0 0.000968 0.000592 0.002334 0 0.060741 8.02E-14 0.002615 0.00393 0.004124 0 0.000596 0 0 0.070273 For0 Peer0 0.002552 Review0 0 0.000406 Only0.001906 0 0.053315 0 0.003607 0.003759 0.008921 0.000388 0.001621 0.000145 0 0.044136 0.000166 0.003006 0.003195 0.017832 2.71E-10 0.001773 0.00078 0 0.247686 0 0.000801 0.00031 0.014234 0 0.000743 0 0 0.134789 1.11E-06 0.006143 0.010864 0 0 0.003647 0.000642 0 0.01793 0 0.000776 0.00038 0 0.002408 0 0.000257 0 0.052993 0.0267 0.001914 0.003077 0 0 0.001677 0.013059 6.85E-06 0.04685 0.000715 0.000753 0.002157 0.002978 0.000497 0.000626 0.002751 0 0.035141 0.018736 0.001956 0.005035 0 0 0.00196 0.003478 0 0.163048 0 0.000706 0.00261 0 0 0.000424 0.001498 0 0.077341 0.001348 0.005613 0.007789 0.032563 0.000124 0.001864 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 159 of 848

PyrobaculumDehalococcoides aerophilumCorynebacterium strain ethenogenes IM2-01Haloarcula kroppenstedtii strain marismortuiBifidobacterium 195-08 strainBurkholderia strain longumDSM ATCC 44385-01Synechococcus subsp.sp.43049-30 CCGE1002-01 infantisEscherichia sp. strain RF-2-30 Streptococcuscoli ATCC strain 15697-01 IAI1-08 agalactiae str. A909-01 0 0.057935 0.000683 0 0 0.003003 2.94E-06 0 0.000473 0 0 0 0 0 0.000542 0 0 0 0 0 0.000928 0.000328 0.000281 0.000954 0 0 0 0 0 5.42E-09 0 0 0.000607 0 0 0 0 0 0.000163 0 0 0.001175 0 0.001751 0 0 0 3.14E-08 0 1.95E-08 0.002127 0 0 0 0 0 0.000955 0 0 0.00217 0.036921 0 0 0 0 0.001549 0 0 0.000995 0 0 0 0 For0 Peer0 0 Review0 0.00114 Only0 0 0 0 0 0.000324 0 0 0.001775 0.174296 0 0 0 0 4.89E-05 0 0 0.002149 0.156577 0 0 0 0 1.36E-16 0 0 0.000857 0.051691 0 0 0 0 0 0 0 0.003408 0 0.001204 0 0 0 0.000572 0 7.64E-05 0.001602 0 0 0 3.82E-20 0 0 0.00392 7.05E-05 0.002614 0 0.001877 0.000241 0 0 0.000631 0 0 0.000245 0.010704 0 0 2.36E-12 0.012112 0 0.001205 6.12E-05 0.002128 0.033294 0 0 0 0 2.34E-10 0 0 0.00036 0.084181 0 0 0 0 0 0 0 0.002273 0.067471 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 160 of 848

Ralstonia solanacearumMesorhizobiumStreptococcus strain loti IPO1609-01 strainHaemophilus sanguinisMAFF303099-01Rickettsia strain influenzae SK36-30 africaeNostoc strain ESF-5-01 sp. 86-028NP-08 strainSymbiobacterium PCC 7120-01Coxiella thermophilum burnetiiStreptomyces str. RSA strain 493-30avermitilis IAM 14863-01 str. MA-4680-30 0.002236 0.03129 0 0 0 0.003571 0.009099 0 0.00303 0.00014 0.003593 0 0 0 0.002629 0.001048 0.1049 0.044884 0.000879 0.009896 0 0.005225 0 0.000777 1.17E-06 0 4.98E-05 0.001111 0.023441 0 0 0 0.00067 8.49E-15 0 0.004966 0.000963 0.011621 0 0 0 0.000125 0.000326 0 0.000185 0.001578 0.015431 0 0.031357 0 0.001276 3.99E-07 0 9.25E-06 0 0.015265 0 0 0 0.000782 0.000104 0 0.000897 0.001207 0.013224 0 0 0 0.000881 0 0 3.08E-05 0.000322 0.012892For Peer0 0 Review0 0.000211 0.000105 Only 0 0.000992 0.000411 0.010015 0 0 0 0.000892 1.15E-06 0.022224 0.013538 0.001494 0.009044 0 0.011922 0 0.000569 0.000594 0.16406 0 0.000704 0.013687 0 0 0.003399 0.000868 1.15E-09 0 0 0 0.021961 0 0 0 0.000479 7.15E-05 0 0.010455 0 0.0115 0 0 0.00398 0.001214 0.002808 0 0 0.001536 0.015147 0 0.026805 0 0.000947 7.90E-05 0 0.014663 0.000556 0.013062 0 0.007017 0.004703 4.64E-05 0.000111 0 0.000121 0.002451 0.016816 7.13E-15 0 0 0.000706 2.14E-06 0 0.005482 0.000472 0.006646 0 0 0.00075 9.79E-07 5.36E-13 0 4.59E-06 0.001449 0.026647 0 0 0 0.000677 1.59E-09 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 161 of 848

StaphylococcusDehalococcoides aureusElusimicrobium subsp. sp. aureus BAV1-01Coprothermobacter str. minutum MW2-30Methylobacterium strain proteolyticusPei191-30Pseudomonas nodulans DesulfohalobiumDSM syringae 5265-30 strainAnaeromyxobacter pv.ORS tomato 2060-01retbaenseStreptomyces str. DC3000-30 strain sp. Fw109-5-30DSM scabies 5692-08 87.22-08 0 0.02149 0 0 0.01296 0.009526 0.042717 0.117359 0.004548 0 0 0 0 0.00154 0.019234 0.011979 0.155111 3.08E-05 0 0 0.005072 0 0.001363 0.007819 0.005203 0.028315 0.001989 0 0 0 0 0.001372 0.114055 0.012582 0 1.03E-05 0 0 0 0 0.001399 0.013746 0.009243 0 0.000395 0.002672 0 0 0 0.002266 0.092229 0.000526 0 0.000195 0 0 0 0 0.003864 0.033228 0.016934 0.002085 0.003385 0 6.89E-19 0 0 0.002127 0.008207 3.81E-06 0 0.001487 0 For0 Peer0 0 0.003772Review0.018136 0.000576 Only0.006294 5.58E-08 0 0 0 0 0.002604 0.037078 0.001927 0 0.000189 0 0.000721 0 0 0.002812 0.042411 9.33E-05 0.04165 0.000875 0 0 0 0 0.002826 0.05458 0.000332 0.012753 2.63E-06 0.017165 0 0 0 0.00483 0.028205 0.010217 0.037809 0.000935 0 0.001332 0 0 0.003001 0.000991 0 0 2.84E-05 0 0 0.034489 0 0.00354 0.029932 0.035077 0.014811 0.006673 0 0 0.021907 0 0.003144 0.019177 3.26E-05 0.006882 0.000196 0.003919 0 0.012372 1.87E-14 0.003949 0.017282 0.018704 0.013258 0.004422 0 0 0 0 0.001181 0.035658 0.005341 0.007352 2.55E-05 0 0 0 0 0.005584 0.027046 0.014845 0.016495 0.001709

Wiley-Blackwell and Society for Applied Microbiology Page 162 of 848

Rhizobium sp.Shewanella ORS571-08Thioalkalivibrio baltica strainBurkholderia OS195-01 sp. K90mix-08Haemophilus mallei strainChlorobium influenzae 10229-08Lactobacillus tepidum strain PittGG-30 strainCorynebacterium brevis TLS-30 strainThiobacillus ATCC kroppenstedtii 367-08 denitrificans strain strain DSM ATCC 44385-30 25259-30 0.063477 0.001042 0.136508 0.002359 0.308004 0 0 0 0 0.023964 0.001336 0.061062 0.005375 0 1.30E-07 0 0 0 0.030556 0.001258 0.063046 0.003488 0 0.009825 0 0 0.041122 0.036216 0 0.121985 0.000915 0 0.014451 0 0 0.016451 0.029878 0.001193 0.041087 0.001758 0 0.01825 0 0 0.008402 0.015221 0 0.234055 0.002465 0 0 0 0 0.045041 0.028055 0.001587 0.081814 0.000628 0 0.013116 0 0 0.032569 0.024768 0.003024 0.170194 0.007177 0 0 0 0 0 0.023047 0.000911For0.042808 Peer0.001676 0.187647Review0.004307 Only0 0 0.0215 0.007494 0.002387 0.137501 0.001651 1.684381 0.006792 0.0002 0 0.044083 0.017714 0.003204 0.157517 0.001987 4.405028 0.070561 0 0 0.075548 0.032856 0.001059 0.073487 0.00242 0.396537 9.98E-09 0 0.022152 0.005653 0.021938 0.004304 0.21693 0.004261 0.847137 7.59E-08 0 0 0.016755 0.00549 0.00099 0.018153 0 0.797325 0.002697 0 0.014983 5.05E-07 0.037138 0.001951 0.134782 0 0.322907 0.024727 1.02E-05 0 0.107549 0.015745 0 0.025533 0.001498 0.748071 0.008924 0 0 0.076516 0.050084 0.003547 0.090025 0.002109 0.068356 0.006347 0 0.000887 0.02325 0.009433 0.000736 0.045212 0.001053 0.314709 0.024101 0 0.000318 0.054919 0.019198 0.003806 0.158309 0.00381 0.189068 0 0 0 0.053972

Wiley-Blackwell and Society for Applied Microbiology Page 163 of 848

Jannaschia Brachyspirasp. DFL-12-30Coxiella hyodysenteriae burnetiiDyadobacter strainBurkholderia CbuG_Q212-08WA1-08 fermentansAcinetobacter pseudomallei strain DSMHalomicrobium 18053-08baumannii strain K96243-08Mesorhizobium strain mukohataei AYE-01Staphylococcus loti strain strain DSM MAFF303099-08 aureus 12286-30 subsp. aureus Mu50-08 0.102463 0.012227 0.10593 0.035448 0.001507 0.002925 0 0.118889 0 0.103479 0.053446 0 0.029056 0.006208 0 0 0.082384 0 0.835546 0.01017 0.028968 0.05325 0.000607 0 0 0.097748 0 2.827223 1.65E-14 0 0.061456 0.002457 0.005373 0 0.106428 0 1.861515 0.016538 0 0.029499 0.000853 0 0 0.087547 0 0.566385 0.039092 0 0.02358 0.001936 0.005025 0 0.086116 0 0.498502 0.01071 0 0.044363 0.000954 0 0 0.080201 6.72E-07 0.312703 0.05034 0 0.04019 0.00055 0.003821 0 0.091355 0 0.572719 0.004201For Peer0 0.030951 0.000364Review0.002638 Only0 0.043943 0 0.606288 0.009405 0 0.044532 0.002436 0.003786 0.01261 0.065675 0 0.650029 0.003244 0 0.028965 0.001083 0.003816 0 0.091598 0 0.573319 0.000328 0 0.019765 0.0077 0 0.021446 0.080671 0 0.613156 0.016969 0 0.051287 0.00221 0.006754 0 0.141659 0 0.134875 0.004413 0.016881 0.011909 6.27E-10 0 0 0.01357 0 0.436911 0.008314 0 0.032943 0.002046 0 0 0.071009 0 0.43218 0.014087 0.007908 0.02004 0.000622 0 0.021748 0.028774 0.001432 0.384053 0.000567 0 0.039587 0.001627 0.004846 0.003688 0.059509 1.41E-05 0.875687 0.023369 0 0.02351 0.000544 0 0 0.065646 0 0.955446 0.022669 0.050208 0.040501 0.001643 0.01018 0.025024 0.139994 0

Wiley-Blackwell and Society for Applied Microbiology Page 164 of 848

RhodococcusNeisseria sp. RHA1-01 gonorrhoeaeStaphylococcusRickettsia strain epidermis NCCP11945-01 felisLeuconostoc strainRP62A-30 URRWXCal2-30Methanobrevibacter mesenteroidesVibrio subsp. sp. smithiiEx25-08Polaromonas mesenteroides strainLactobacillus ATCC sp. strainJS666-08 35061-30 ATCC johnsonii 8293-08 NCC 533-08 0.003189 0 0 0 0 3.21E-05 0.002017 0.141944 0 0.000309 0.00038 0 0.198838 0 0 0.065047 0.011757 0 0.00114 0 0 0.067641 0 0 0.015234 0.016572 0 0.001917 0.001761 0 0 0 0 0.060868 0.015464 0 0.001044 0.002482 0 0 0 0 0.021512 0.003804 0 0.001149 0.002355 0 0 0 0 0.072303 0.026421 0 0.001985 0.005034 0 0 0 0 0.027389 0.020623 0 0.001661 0.00419 0 1.84E-17 0 0 0.082958 0.015283 0 0.001009 0.002155For Peer0 0 Review0 0 Only0 0.007661 0 0.0021 0.001288 0 0 0 0 0.064021 0.013393 0 0.001625 0.005009 0 0 0 0 0.069133 0.0106 0 0.001287 0 0 0.051569 0 0 0.05936 0.035053 0 0.002612 0 0 5.18E-10 0 0 0.099981 0.024195 0 0.000534 0 0 0 0 0.000149 0 0.001706 0 0.002263 0 0 0 0 0 0.037709 0.022409 0 0.000482 0 0 0 0 0 0.016886 0.006163 2.39E-07 0.000828 0 0.00133 0.004997 3.03E-05 0.010368 0.022821 0.016058 0 0.000258 0.000241 0 0 0 0 0 0.002595 0 0.002865 0.001337 0 0.018925 0 0 0.087006 0.025319 0

Wiley-Blackwell and Society for Applied Microbiology Page 165 of 848

Legionella pneumophilaPseudoalteromonasChloroflexus subsp. pneumophilaatlanticaStenotrophomonas aggregans strain Candidatusstrain strain T6c-30 Philadelphia DSM maltophilia BacillusLiberibacter 9485-01 cereus1-01 strainSalmonella asiaticus strainK279a-30 G9842-30 strain Thermodesulfovibrioenterica psy62-01 subsp.Haliangium enterica yellowstonii ochraceum serovar Typhi DSM strain str. 11347-08 DSM Ty2-08 14365-01 0.014362 1.727739 0.007472 1.22E-08 0.000833 0 0 0.05988 0.015547 0.002031 1.746661 1.10E-05 0 0.000497 0.000631 0.003904 0 1.67E-05 0.001757 0.034918 0.000713 0.020716 0.001894 0 0.002482 6.23E-06 0.000308 0.003542 0.937729 0 0.031907 1.78E-05 0 0.010528 0 0.001002 0 1.029678 0.000372 0.003692 0.001361 0 0 0.006311 0.000129 0.00539 0.75289 0.000756 2.65E-06 0.003887 2.78E-05 0.018366 0 0.001143 0.007282 0 0.003922 0.016548 0.006161 0 0 0.020178 0.002187 0.007026 0.856286 0.000774 0.049348 0.001501 0 0 0.007456 0.000184 0.00478 1.089675For6.19E-06 Peer0.004743 0.00612Review0 Only0 0.008045 0.0009 0.002305 0.943326 0.000453 0.002071 0.000256 0.000125 0.005538 0.001391 0.000265 0.004893 0.646622 0.000128 0.060829 0.004853 0 0 0.004916 0.000388 0.006203 7.441562 0.000321 0.008941 0.00436 0 0 0 0.001431 0.007712 0.907752 0.000451 0.022452 0.001616 0 0 0.006479 0.001706 0 0.402244 0.001284 2.42E-05 0.005932 0 0 0 0.001143 0 0.315701 0.002039 0.0479 0.00526 0 0 0.030082 0.001289 0.003954 1.957811 0.001496 0.00109 0.003514 0 0 9.46E-07 0.001418 0.005808 0.194127 0.002202 0.01464 0.001026 0.000962 0.007319 0.032424 0.002061 0 4.024021 7.82E-06 0 0.001044 0 0.006676 0.005304 0.000635 0.003983 0.508707 0.001149 0.012538 0.001111 0 0.023922 0.001026 0.001232

Wiley-Blackwell and Society for Applied Microbiology Page 166 of 848

PectobacteriumHelicobacter wasabiaeAnaeromyxobacter hepaticus strain WPP163-08Neisseria str. ATCC sp. meningitidis 51449-08Vibrio K-01 cholerae Aggregatibacterstrain strain FAM18-30 O395-08Salmonella actinomycetemcomitans Mycoplasmaenterica subsp.Francisella synoviae enterica strain tularensisstrain serovar D11S-1-08 53-01 subsp.Enteritidis holarctica strain P125109-01strain OSU18-30 0.02368 0.021853 0.004125 0 0 0 0 0 0 0 0 7.96E-05 0 0 0 0 0 0 0.006804 0.001732 1.15E-07 0 0 0.001225 0.000185 0 0.01914 0.010071 0.001865 2.53E-21 0 0.010037 0 0 0 0 0.006182 0.000144 1.72E-05 0 0.015202 0.011296 0 0 0 0 0.001816 0.000771 0 0.099026 0.032096 0.002529 0 0 0 0 0.000577 2.23E-08 0 0 0 0 0.045514 0 0 0.000942 0.099957 0 0 0 0 0 0.005455 7.34E-05For3.69E-05 Peer0.013548 Review0 0.010239 Only0 0 0 0.016735 0.000612 0.000372 0.061826 0.080992 0 0.001106 5.87E-09 0 0 0 0.000547 0.025272 0 0 0 0 0 0.004548 0 7.78E-05 0 0 0 0 0 0 0.022464 0.00797 0.000118 0 0.091041 0.070516 0 0 0 0 0 0.000813 0.00779 0.011 0.011206 0 0 0 0.014676 0 0.002038 0 0 0.008672 0 0 0 0.003278 0.002054 0.000582 0.016467 0 0.007855 0 0 0 0.006721 0.000139 0.001309 0.001819 0.01186 0.010166 0 0 0 0.009424 0 3.12E-05 0.015958 0 0.030568 0 0 0 0.024341 0 0.000137 0.056938 0.075941 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 167 of 848

Colwellia sp.Enterobacter 34H-30 Streptococcus sp. 638-08Brucella agalactiae abortusIgnicoccus str. bv. A909-08 1 sp.strainSilicibacter Kin4-I-08 9-941-08 Akkermansiapomeroyi DSS-3-30Erwinia sp. Muc-30 amylovoraTolumonas strain auensis ATCC strain49946-01 DSM 9187-01 0.772707 0.002899 0 0 3.20E-14 0.362107 1.322891 0 0.005181 0.159792 0.011931 0 0 0 0.648867 0 6.46E-05 0.004975 0.075828 0.00832 0 0.016997 0 1.189869 0.056265 0 0.003163 1.777631 0.00891 0 0 0 4.695531 0.007808 0.002649 0.005061 1.039354 0.001874 0 0 0 2.969573 0.017122 0.002383 0.006934 0.858461 0.009359 0 0 0 1.345771 9.00E-08 0.003491 0.01544 1.310975 0.00598 0 0 0 1.000227 0.074677 0 0.016154 0 0 0 0 0 1.682122 0.185162 0 0.009088 1.609812 0.006823For Peer0 0.018685 Review0 0.787442 0.118025 Only 0 0.007017 0.337808 0.009403 0 0 0 1.15193 1.30E-13 0 0.007242 0.479777 0.018762 0 0 0 1.362537 0 0 0.007623 10.11531 0 0 0 0 1.011432 0.030724 0 0.004976 1.020639 0.03077 0 0 0 1.02289 0.015327 0 0.024242 0.526233 0 0 8.72E-08 0 0.33028 0.22181 0.00148 0.003935 0.61071 0.009634 0 0.029618 1.69E-08 0.634714 0.357521 0.002431 0.007266 3.050272 0.007883 0 0 0 0.637679 0.392285 0 0.00609 1.020448 0 0.000711 0 0 0.499573 0.190589 0 0.012215 4.029094 0.009978 0 0 0 1.622639 0 0.00069 0.002386 0.438481 0.01689 0 0 0 1.224271 0 0 0.021494

Wiley-Blackwell and Society for Applied Microbiology Page 168 of 848

MycobacteriumProchlorococcus tuberculosisCampylobacter marinus strainCampylobacter F11-30 subsp. jejuni marinus subsp.Lactococcus fetus doylei str. subsp. SS120-08Streptococcus lactisstrain fetus subsp. 269.97-30 Clostridiumstrain cremoris pneumoniae 82-40-08Streptomyces strainbotulinum strain SK11-01 StaphylococcusTaiwan19F-14-08A strainavermitilis ATCC str.19397-08 aureus MA-4680-01 subsp. aureus strain Newman-08 0 0 0 0 0 0 0 0.002255 0 0 0 0 0 0 0 0 3.00E-05 0 0 0 0 0 0 0 0 2.95E-05 0 0 5.47E-12 0 0.00016 0 0 0 1.08E-05 0 0 0.024232 0 0.003293 0 0 0 0.00014 0 0 0 0 0 0.00056 0 0 7.55E-05 0 0 0 0 5.20E-15 5.95E-08 0 0 0.000527 0 0 0 0 0 0 0 0 0.000372 0 0 0.004262For Peer0 0 Review0 0 Only0 0.000183 0 0 0.004044 0 0.004787 0 0 0 7.43E-06 0 0 0.003401 0 0 0 0 0 0.000332 0 0 0 0 0 0 0 0 0.000114 0 0 0.009575 0 0 0 0 0 7.80E-05 0.002724 0 0.054452 0 0 0 0 0 0.000164 0 0 1.06E-07 0.019907 0 0 0 0.006496 0.000523 0 0 0.026245 0 0.000575 0 0 0 1.69E-06 0 0.000484 3.88E-06 2.67E-14 2.05E-07 9.63E-08 0 0 0.000736 0 0 0.004942 0 0 0 0 0 4.00E-16 0 0 0.00205 0 0 0 0.003341 0 0.00082 0

Wiley-Blackwell and Society for Applied Microbiology Page 169 of 848

ShewanellaProchlorococcus baltica strainEhrlichia OS155-30 sp. MIT9312-30canisNeisseria strain meningitidisJake-30Klebsiella pneumoniae Thermococcusstrain 053442-30Archaeoglobus subsp. onnurineus pneumoniaeLactobacillus profundusstrain strain NA1-30Aeromonas fermentum strain MGH DSM78578-08 hydrophila strain 5631-30 IFO subsp. 3956-30 hydrophila strain ATCC 7966-30 0 0 0 0 0.002028 0 0 0 0.068202 0 0.078148 0 2.20E-05 0.002175 0 0 0 0.0874 0 0 0 0.092978 0.002523 0 0 0 0.001496 0 0 0 0 0 0 0 0 0.127543 0 0.034221 0.009182 0.013962 0 0 0 0.021803 0.014964 3.03E-06 0 0 0.053292 0.010792 0.106642 0 0.175627 0.00721 0 0 0 7.92E-05 0 6.77E-11 0.01052 0 0.06571 0 0 0 9.03E-06 0.020336 0 0 0.337461 0.093446 0 For0 0.012391 Peer0 0.007621Review0 Only0 0.018279 0.035296 0.009338 0.023507 0 0.057188 0 0 0 0.06202 0.03612 0 0 1.41E-07 0.025875 0.006935 0 0 0.282621 0.049592 0.081391 0 0 0 0.00424 0 0 0.038895 0.114362 0 0.023233 0 2.66E-07 0.00744 0 0 0 0.059089 0 0.01104 0 0 0 0 0 0.006289 0.006974 0 0.001841 0 0 0.004092 0 0.002415 0 0.069184 0.020633 0.018785 0 0.023804 0.002816 0 0 0.022296 0.044077 0 0 7.16E-13 0.005122 0.003758 0.000187 0.001301 0.010991 0.021702 0 0 0 0 0 0 0 0 0.10538 0.013238 0.101241 0 0 0 0 0 0.039735 0.074493

Wiley-Blackwell and Society for Applied Microbiology Page 170 of 848

XanthomonasPseudomonas oryzae pv.Xanthomonas oryzae fluorescens strainPseudomonas campestris strain KACC10331-01 Pf0-1-08Halothiobacillus putidapv. campestris strainSynechococcus W619-01neapolitanus strainXanthomonas B100-08 sp. WH8102-08strainAzoarcus c2-30euvesicatoria sp.Yersinia BH72-08 str. pseudotuberculosis 85-10-01 strain IP 32953-01 0.001235 0.044661 0.00586 0.006161 0 0.019938 0.003856 0.03518 0.000454 0.000314 0.093402 0.005115 0.001591 0 0.00441 0.000689 0.020783 1.27E-05 0.000304 0.02251 0.003953 0.00442 0.039235 0.05189 0.001238 0.015974 0.000246 0.002286 0.051959 0.00319 0.010804 0.147069 0 0.000973 0.0217 8.07E-05 0 0.028086 0.003785 0.004799 0.027181 0.022667 0.00139 0.012876 0.000199 0 0.115792 0.011104 0 0 0.00286 0.001442 0.028473 0.000909 0 0.036651 0.005554 0.008701 0.016435 2.55E-05 0.002392 0.0224 0.00088 0.000538 0.132901 0.008506 0.008115 0.190985 0.004958 0.000764 0.042621 0.00095 0 0.024904For0.000629 Peer0.00327 0.037484Review0.097163 0.001215 Only0.010437 0.000324 0.00051 0.093121 0.005912 0.007541 0 0.005604 0.000334 0.029058 0 0 0.114687 0.005035 0.008088 0.087549 0.006174 0.001502 0.028222 0 0.000377 0.037105 0.001318 0.008311 0.107801 0.034434 0.000608 0.045013 0 0 0.159454 0.01261 0.035346 0.010923 0.006777 0.002677 0.046938 0 0 0.002645 0 0.001918 0 0.528024 0.000947 0.008076 0 0 0.043097 0.005646 0.006617 0.075295 0.000241 0.001923 0.05774 0 0.000366 0.022396 0.000843 0.002518 0.033561 0.563648 0.000654 0.003148 8.10E-05 0 0.037187 0.005982 0.00819 0.035364 0.002254 0.002529 0.040625 0 0 0.035852 0.002561 0.001979 0.026243 0.002233 0.000557 0.008897 7.95E-06 0.002587 0.110077 0.009409 0.026248 0.000704 0.004731 0.001435 0.034109 0

Wiley-Blackwell and Society for Applied Microbiology Page 171 of 848

LactobacillusCandidatus johnsonii SalinisporaBlochmanniaNCC 533-01 Escherichiaarenicola floridanus-01 strain Listeriacoli strain CNS-205-08 innocua S88-01Frankia strain alni HistophilusClip11262-01 strain ACN14a-30 Arcobactersomni str. 2336-30 Synechococcusbutzleri strain RM4018-30 sp. WH8102-30 0 0.010467 0.003591 0 0.000428 0.003203 0.516182 0 0.037366 0.000762 0 0 0 0 0 1.455626 0 0 0 7.07E-05 0.000597 0 9.28E-05 0 0 0.001244 0.008075 0 0 1.91E-09 0 0 0.004172 0.115185 0.012424 0 0 0.007164 0.002119 0 9.97E-05 0.006111 0.040492 9.85E-24 0.015592 3.55E-06 0.003303 0 0.000193 9.14E-05 0 0.818152 0 0.028964 0 0 0.004792 0 0 0.012334 0.099484 0.002068 0 0 0.000643 0.000401 0 0 0.012486 0.16254 0 0.050479 0 0.003735For0.001358 Peer0.00012 Review0 5.95E-10 0.10391 Only0.010093 0.084107 0 0.001358 0.000281 0.000186 0 0.016422 0.18185 0 0 0.000757 0.003408 0.001057 0 1.25E-05 0.019074 0.109453 0 0.015034 0 0 4.36E-07 0 0 7.55E-06 0.036796 7.14E-05 0.018076 0 0.006161 2.10E-05 0 0 0 0.049065 0.014589 0.011549 0 0.00146 0 0 0 0 0 0 0.365174 0 0.000316 0.00124 0 0.000102 0.000586 0.026423 0.042517 0.007201 0 0.000315 4.42E-05 0 1.10E-05 0.001679 0.064424 1.01E-05 0.349732 0 0.003644 0.001895 0 0 0.007175 0.04202 0.011462 0.01608 0 0.000232 0 0 0 0 0.013717 0 0 0 0 0 0 0.00019 0 0.095821 0 0.037635

Wiley-Blackwell and Society for Applied Microbiology Page 172 of 848

Rickettsia rickettsiiChlamydia strain trachomatisThermocrinis 'Sheila Smith'-08Legionella strain albus 434/Bu-08 strain pneumophilaDeferribacter DSM 14484-08Catenulispora subsp. desulfuricans pneumophilaHelicobacter acidiphila strain ThermococcusSSM1-01strain pyloristrain Philadelphia strainDSMPsychrobacter 44928-01 G27-01gammatolerans 1-30 sp. PRwf-1-01 strain EJ3-01 0 0.001498 0.012934 0 0.036231 0.005424 0 0.004157 0.001077 0 0 0 0.044395 0.000538 7.94E-07 0 0 0.002594 0 0 0 0 0.001667 1.31E-05 0 4.85E-06 0.004199 0.01075 0 0 0.005458 0.003283 3.29E-08 0 0 0.008583 0 0 0 0.012118 0.004197 2.24E-05 0 0 0.009563 0 0 0 0 0.000648 2.12E-05 0 0 0.014712 0 0 0.004574 0 0.000203 0.000526 0 1.71E-12 0.013598 0 0 0 0 0.000343 0.001003 0 5.75E-11 0.012598 0 For0 0.000721 Peer0 0.00087Review0.000427 Only0 0 0.009413 0 0 0 0.007955 0.002076 3.83E-05 8.14E-11 7.82E-05 0.012429 0 0 0 0 0.003296 1.60E-05 0 0 0.011155 0 0 0 0 0.000265 2.45E-05 1.33E-13 0 0.007231 0 0 0 0 0.001662 1.53E-06 0 8.70E-07 0.024294 0 0.005018 0 0 0.000309 0.00043 1.50E-05 8.23E-05 0.007054 0 0 0.007929 0.055902 0.008293 0.000417 0 2.34E-05 0.017262 0.005064 0 0 0.009508 0.000604 0.000441 0 0 0.0033 0 0 0.000658 0.009537 0.010719 0.000916 1.43E-05 0.002106 0.020024 0 0 0 0.011237 0.000542 5.12E-16 0 0 0.001785 0 0 0 0.012373 0.001095 2.18E-05 1.45E-07 0 0.027555

Wiley-Blackwell and Society for Applied Microbiology Page 173 of 848

Veillonella parvulaAtopobium strainMethylotenera parvulum DSM 2008-08 strainEscherichia mobilis DSM 20469-30 Thermanaerovibrio colistrain O157:H7 JLW8-01Maricaulis EDL933-01 acidaminovorans marisClostridium strainFlavobacterium MCS10-30cellulolyticum strain DSMEggerthella 6589-01strain psychrophilum H10-08 lenta strain strain DSM JIP02/86-30 2243-01 0.033996 0 0.062859 0.000469 0.021544 0.13401 0.002596 0.507171 0.000107 0 0 0.04545 0 0 0.121509 7.90E-24 1.375899 9.24E-06 7.23E-07 0 0.044425 0 0 0.014932 0.002425 2.396069 6.16E-05 6.50E-05 0 0.071712 0 6.33E-10 0.059055 0 1.308356 0 0.000146 0 0.054695 0 0 0.040845 0 1.43073 1.36E-11 0 0 0.119593 0 0.000134 0.000202 0 0.957288 0.00082 0 0 0.165348 0 0 0.027266 0.004004 0.904636 1.78E-17 0 0 0.081227 0 7.78E-05 0 1.39E-09 1.192185 0.000369 0 For0 0.10162 Peer0.000288 Review0 0.057874 0.000424 Only0.817188 3.09E-20 0.000102 0 0.074784 0 0 0.000678 0.000152 2.688357 1.48E-05 0.000635 0 0.078489 0 0.000767 0.065244 0 1.462814 0.00013 0 0 0.058994 0 0 0.021054 0 1.595406 5.07E-10 6.55E-05 0 0.078369 0 0.00357 0.029621 0.001698 3.180965 1.29E-06 0 0 0.082121 0 0 0.0463 0 0.466914 6.91E-11 1.30E-07 0 0.091781 0 0.004332 0.019589 0.000122 0.657879 8.11E-05 0.000379 0 0.04862 0 0 0.025577 0 0.636806 1.12E-11 0.012041 0.017464 0.150894 0 0.001884 0.037033 0.0038 0.63535 0.001917 0 0 0.051022 0 9.02E-06 0.044832 0 0.774899 2.97E-16 0 0 0.074148 0 0 0.001343 3.66E-06 2.139302 1.70E-05

Wiley-Blackwell and Society for Applied Microbiology Page 174 of 848

DSM 13-01 HydrogenobaculumNitrosomonas sp.Oligotropha Y04AAS1-08 europaeaStaphylococcus carboxidovorans str. ATCC Buchnera19718-30 carnosus strain aphidicolaYersinia OM5-08subsp. pseudotuberculosis straincarnosusstrainXylella 5A fastidiosa (AcyrthosiphonBradyrhizobium TM300-08 strainstr. Temecula1-30 PB1/+-30pisum)-08 sp. BTAi1-08 0.002142 0.005976 0.00509 0.103823 0 0 0 0 0.047134 3.15E-15 0 0 0.007612 0 0 0 2.80E-06 0.022056 5.71E-06 0.016947 0.051974 0.02447 0 0 0 0 0.01385 0 0 0.04806 0.002552 0.001154 0 0 0.090386 0.018628 5.02E-15 0.001231 0.016294 0.020748 0 0 0.002457 0 0.004196 0 0 0 0.018892 0 0.071958 0.007732 0 0.020668 1.02E-05 0.003884 0.05441 0.016252 0 0.027667 0.003545 0 0.012073 0.00022 0 0.175418 0.016517 0 0 0 0 0.022782 0 For0 0.036043 Peer0.01052 Review0 0 0.004983 Only0.029617 0.006102 1.75E-23 0.012012 0 0.018332 0 0.020535 0.086009 0.05563 0.015268 2.29E-05 0.002193 0.096953 0.01824 0 0 0.154972 0.166862 0.01275 3.57E-06 0 0.034605 0.02352 0 0 0.018037 0.032466 0.008437 3.07E-05 0 0 0.013318 0 0 0.02421 0 0.021471 5.37E-06 0.000459 0.048249 0.008637 0 0 0 0.008815 0.008378 1.94E-05 0.014091 0.130343 0.025752 0.000339 0 0 0.010945 0.017457 2.10E-13 0 0.019531 0.019037 0 0 0 0.025564 0.006786 6.16E-06 0.008196 0.028606 0.040807 0 0 0.004172 0.015546 0.02669 9.54E-07 0 0.058256 0.004204 0 0 0.01073 0 0.007453 0.000142 0.005839 0.014718 0.018617 0 0 0.03217 0.036524 0.027216

Wiley-Blackwell and Society for Applied Microbiology Page 175 of 848

StaphylococcusDickeya aureus dadantiiMethanosarcina subsp. strain aureusNanoarchaeum Ech703-01 strain barkeri Newman-01bacterium strain equitans Fusaro-30 2-40-01Dyadobacter str. Kin4-M-01Neorickettsia fermentansBurkholderia risticiistrain strainDSMMarinomonas sp. 18053-01 Illinois-08 PsJN-08 sp. MWYL1-30 0 0.007436 0.045971 0.002224 0.041991 0.018216 0 0.030372 0.145687 0 0.000742 0.167976 0 0.024365 0.002411 0 0.002288 0.754012 0 0.002521 0 0 0.060835 0.00561 0 0.00362 0.212379 0 0.002645 0 0 0.146421 0.004706 5.50E-23 0.007056 1.512561 0 0.001592 0.009402 0 0.067423 0.005714 1.07E-08 0.004028 0.162686 0 0.003397 0.237952 0 0.110196 0.009618 0 0.005626 0.379671 0 0.001917 0 0 0.120696 0.00585 0 0.00137 0.297601 0 0.001211 0.303641 0 0.126892 0.009381 0 0.011165 0 0 0.002585For0.023616 Peer0 0.074193Review0.00294 Only0 0.003883 0.287961 0 0.002402 0.075792 0 0.109041 0.011712 1.99E-06 0.004097 0.705437 0 0.002944 0.135299 0 0.088762 0.017349 1.66E-17 0.005032 0.912548 0 0.000732 0 0 0.117661 0.007424 0 0.001897 0.646279 0 0.007109 7.51E-10 0 0.25231 0.010748 0 0.013175 0.884512 0 0.001556 0.024639 0 0.034315 0.006799 0 0.002098 0.064199 0.000653 0.000791 0 0 0.076688 0.00494 0 0.015111 0.299318 0 0.002089 0.007526 0 0.0375 0.00244 0 0.002092 0.441829 0 0.000949 0.000805 0 0.115269 0.010658 0 0.005658 0.201624 0 0.000289 0.044003 0 0.026174 0.001398 0 0.00167 0.715673 0 0.005752 0.01711 0.006552 0.28399 0.017705 0.001362 0.007097 0.844393

Wiley-Blackwell and Society for Applied Microbiology Page 176 of 848

Silicibacter Rhodospirillumsp. TM1040-08Syntrophus rubrumSynechococcus aciditrophicus strain ATCCRubrivivax 11170-01 strainsp. strain SB-08 gelatinosusShewanella RF-1-01 Buchnera PM1-01sediminis aphidicola strainRhodococcus HAW-EB3-08 str.Anaerocellum Bpopacus (Baizongia strain thermophilum B4-08pistaciae)-08 strain DSM 6725-01 0.201428 0.059165 0.093552 0.0036 0.009889 0.01977 0 0.011042 0.007129 1.49195 0.00611 0 0.006075 0.001077 0.1708 0 0.00146 0 2.730788 0.009745 0.000301 0.000974 0.00761 0.022058 0.015735 0.001875 3.48E-07 3.085439 0.002816 0.000672 7.39E-09 0.014484 0.05117 0 0.006173 0 2.342432 0.012577 0.003926 0.000218 0.002412 0.018006 0 0.004345 4.98E-06 2.00727 0.007716 2.94E-16 0.005054 0.010622 0.093675 0 0.008685 0.001306 0.844756 0.031523 0.000991 0.001109 0.007696 0.036911 0 0.006803 0.000612 1.57486 0.011574 0.000116 0.001042 0.006713 0.064931 0 0.004811 5.55E-06 0.926546 0.016886For0.004512 Peer0 0.001102Review0.009999 Only0 0.001461 8.65E-05 1.139859 0.005087 0.003158 0.001762 0.005242 0.073815 0 0.005455 0.000501 1.190341 0.014624 0.001019 0.002069 0.004234 0.095535 0.005231 0.002819 3.88E-05 2.623686 0.016822 0 0.000652 0.001091 0.04322 0 0.000603 6.22E-05 2.241898 0.008157 0.004452 0.00083 0.027315 0.143604 0.028782 0.010332 0 0.347491 0.021925 0.003221 0.000998 0.006087 0.007467 0.018289 0.000792 0.000149 1.020761 0.021047 0.013458 0.00112 0.006668 0.035225 0 0.006901 0.000238 0.938128 0.021456 0.003502 0.000351 0.002726 0.011336 0 0.001237 0.00031 0.544813 0.033714 0.024041 0.002097 0.01198 0.038288 0.017156 0.004941 0.002061 2.064384 0.006683 0.003063 0.000149 0.000939 0.040457 0 0.005692 2.26E-05 2.392849 0.007912 0.007763 0.000827 0.017272 0.113191 0 0.001692 4.31E-09

Wiley-Blackwell and Society for Applied Microbiology Page 177 of 848

SalinosporaRhodoferax sp. CNB440-01Escherichia ferrireducens Salmonellacoli strain O55:H7 T118-08 Chlamydiaenterica strain CB9615-08 subsp. trachomatisSulfurihydrogenibium entericaEscherichia MoPn serovar strain Choleraesuis azorense Kineococcus-likecoli Nigg-01 strain strain S88-08Sphaerobacter strain Az-Fu1-30 str. SC-B67-08 SRS30216-01 thermophilus strain DSM 20745-01 0.003696 0.081225 0.014085 0 8.92E-06 0 0 0.000623 0.031382 0 0.009726 0 0 0 0 0 1.01E-18 6.86E-06 4.83E-05 0.012291 0 0 4.87E-25 0 0 0.000206 0.000274 6.70E-05 0.010591 0 0 0 0 0 0.001647 0 0.000289 0.002829 0 0 0 0 0 0.001055 0.000417 3.79E-05 0.024948 0 0 0.000171 0 0.00423 0.000596 6.45E-08 2.98E-05 0.004469 0.000738 0 0.001094 0.000136 0 0.00065 0.002368 0.000156 0.018514 0 0 0 0 0 0.000117 6.53E-05 3.56E-05 0.000579For Peer0 0 Review0 0 Only0 2.70E-18 4.94E-07 0.000553 0.020778 0.012073 0 0 0 0.00115 3.05E-18 1.82E-07 0.000322 0.024748 0 0 0 0 0 5.73E-05 8.54E-07 1.03E-05 0.004917 0.008966 0 0 0 0 0.000254 4.99E-09 0.000198 0.020213 0 0 0 0.060807 0 0.0008 2.18E-07 0.001496 0.000779 0 1.83E-11 0 0 0 0.000658 8.32E-05 0.000589 0.01316 0.020758 0 1.38E-13 0.034545 0 0.001097 0.001866 0.000384 0.004753 0 0 0 0 0 1.22E-05 5.54E-10 0.000805 0.012823 0.000818 0 0 0.000247 0 0.000794 0.00274 7.05E-06 0.010612 0.001692 0 0 0.052523 0 7.21E-07 4.11E-07 0 0.025224 0 0.005024 0.002464 0 0.001011 9.32E-06 0.00048

Wiley-Blackwell and Society for Applied Microbiology Page 178 of 848

AcinetobacterSyntrophomonas baumanniiBrucella strain wolfei sp. SDF-08Streptococcus CCM subsp. 4915-08 wolfeiCampylobacter uberis strain str. Goettingen-30Acinetobacter 0140J-30 jejuni subsp.Escherichia baumannii jejuni Prochlorococcuscoli strain strain IAI39-08 81-176-08 AB307-0294-01methanogenic marinus str. archaeon NATL1A-08 6A8-08 0.026527 0 0 0 0 0 0 0.005346 0.014182 0 0.063824 0 0 0 0 0.007756 7.75E-05 0 0.026167 0 0 0 0 0 0 0.013027 0 0 0 0 0 0 0 0 0 0 0 0 0 0.002368 0 0 0.002372 0.005316 0 0.07051 0.127719 0 0 0 0 0 0.003906 0 0.017344 0 0.019907 0 0.007262 0 0.000152 0.022646 0 0.108715 0 0 0 0 0 0 0.009538 0 0 For0 Peer0 0 Review0 0.003023 0.005563 Only0.004591 0 0.031761 0 0 0 6.92E-10 0 0 0.003687 0 0.052363 0.001105 0 0 0 0 0.00183 0.000679 0.003873 0 0 0 0 0 0 0 0 0 0.057912 0 0.074538 0 0 0 0 0.009442 1.62E-05 0 0 0 0 0 0 0 0 3.46E-06 0 3.30E-06 0.044041 0 0 0 0 0 0.016819 0.016952 0 0 0 0 0 0 0.045636 0.000391 0.010356 4.01E-10 0 0.008943 0 0 0.000736 0.005449 0.006037 0.026039 0 0.009944 0 0 0 0 0.008144 0 0.057108 0 0 0 0 0 0 0.008202 1.80E-05

Wiley-Blackwell and Society for Applied Microbiology Page 179 of 848

Rickettsia rickettsiiProchlorococcus strainSulfurihydrogenibium 'Sheila sp. MIT9313-01 Smith'-01Pectobacterium azorenseListeria carotovora seeligeri strainRickettsia Az-Fu1-01 subsp.serovar belliiStackebrandtia atroseptica 1/2b strain strain RML369-C-01Leptospira str. SLCC3954-01 nassauensis SCRI1043-01 interrogansBifidobacterium strain DSMserovar longum44728-08 Copenhageni str. DJO10A-01 strain Fiocruz L1-130-08 0.013645 0.003542 0.016745 0.000221 0 0.01209 5.30E-05 0.030189 0 0 0 1.28E-05 0 2.47E-06 0.001828 0.005097 3.06E-05 5.78E-13 0 0.000168 2.51E-05 0.000164 0.000846 0.005044 0.002839 0.002267 0 0 0 0 0.00188 0 0.000557 0 2.11E-06 0 0.000777 3.61E-05 0 0.001617 0.000234 0.003558 5.49E-06 0.00104 0 0.003133 0 0 0.003034 0 0 0.002897 0 0 0 0.000306 0.00242 0 2.22E-05 0 0 0.017125 0 0 0.000312 0.003056 0.00073 0.000444 0 0.017875 0.005316 0 0 0.000897For0.0011 Peer0.001828 0.000754Review0 0.00254 Only0.003597 0 0 0 1.88E-08 0.000928 3.29E-06 0.000981 0.001074 0.018633 0 0 0.001037 0.000553 0 5.42E-05 0.006577 0.000348 0.002325 9.23E-06 0 0 0.000573 0.001405 0.000508 0.008027 0.007283 0 0 0 2.82E-07 0.002416 0 1.20E-07 0.00671 0.004978 0.008858 0 0 0.000629 0.000662 0.000824 0 0.012762 9.48E-06 0 0 0 0.000324 0.005494 0.001771 0.000125 0 0.003865 0.021599 0 0 3.63E-05 7.55E-06 0 0 0 0.000311 0 0 0.00404 0.000933 0.0005 0.001851 0.000139 0.003472 0.002096 0.017458 0 0 3.32E-05 1.37E-05 0.000521 0 0 0 0.002315 0 0 0 0 0.002179 0 0 0.00017 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 180 of 848

Dickeya dadantiiThermotogales strainPseudomonas Ech586-08 bacteriumChitinophaga syringaeTBF 19.5.1-30Caulobacter pv. pinensis syringae Idiomarinastrain vibrioides strain DSM B728a-30 Polynucleobacterloihiensis2588-08CB15-08 strainCytophaga L2TR-01 necessarius hutchinsoniiZymomonas subsp. mobilisstrain necessarius ATCC subsp. 33406-01 strain mobilis STIR1-30 strain ZM4-30 0.009378 0 0 0.048919 0 0.010037 0 0.037916 2.27E-13 0.012231 0 0.021366 0.021645 0 0.003953 0 0.009116 0 0.011811 0.003391 0.012322 0.043125 0.037663 0.017139 0.027135 0.009932 0.005915 0 0 0.13085 0.052081 0 0.017254 0 0.010931 0 0.005079 0 0.031452 0.032934 0.042431 0.017264 0.031991 0.008015 0 0.010526 0 0.044684 0.028993 0.041072 0.032079 0 0.013202 0 0.007972 0 0.031271 0.028051 0.032689 0.035446 0.003098 0.01805 0 0.011246 0 0.036532 0.046734 0.016963 0.046482 0 0.030624 0 0 1.42E-15For0.026635 Peer0.02093 Review0 0.017524 Only0 0.009481 0 0 0 0.046828 0.032853 0.017895 0.02179 0 0.03172 0 0 0 0.050556 0.017897 0 0.027111 0 0.046639 0 0 0 0.045372 0.048736 0 0.015627 0.00893 0.014545 0 0.019634 0 0.066125 0.043705 0 0.068635 0 0.019095 0.044062 0.000969 0.008776 0.001361 0.010796 0.008755 0.016042 0.003564 0.010795 0.002549 0 1.74E-09 0 0.024805 0 0.020783 0 0.010587 0 0 0 0.024719 0.00915 0 0.00833 0 0.007826 0.001389 0.003215 0 0.019848 0.023483 0 0.034052 0.003875 0.019442 0 0 0 0.028682 0.007625 0 0.011229 0 0.004972 0 0.020333 0 0.049426 0.036807 0.025394 0.054903 0 0.023745 0

Wiley-Blackwell and Society for Applied Microbiology Page 181 of 848

MicrocystisCampylobacter aeruginosaHaemophilus NIES-843-08 jejuni subsp.Lactobacillus influenzae jejuniMycobacterium strain straincasei NCTCstrain PittEE-30Pelobacter 11168-30 BL23-01 bovis BCGHaemophiluspropionicus strain TokyoPyrococcus strain influenzae 172-01 DSM Bartonellafuriosus 2379-01 strain PittEE-01 strain henselae DSM strain3638-01 Houston-1-08 0.015841 0 0 0 0 0.022333 0.000244 0.004418 0.054867 0.018868 0 0.013923 0 0.000125 0.000316 0 0 0.008385 0.021775 0 0.002581 0 0 4.67E-05 0.001613 3.34E-05 0.019148 0.006686 0 0.037267 0 0 5.86E-11 0 0 0.001111 0.005583 0 0.000955 0 0 0.001413 0.004494 0 0 0.018904 0 0.035204 0 0 0.001858 0 0 0.009328 0.006489 0 0.045354 0 0 0.000635 0 7.43E-18 0 0.038972 0 0.272081 0 1.81E-09 0.002291 0 6.24E-12 0 0.003103 For0 0.045557 Peer0 7.37E-05Review0.000233 0.005507 Only 0 0.027951 0.01575 0 0.005754 0 0 0.000133 0.003103 0.000898 0.005367 0.004717 0 0.047813 3.02E-06 8.33E-05 0.0012 0.005442 5.92E-12 0.00948 0.059526 0 0.045219 0 0 0.000737 0.005178 0 1.14E-06 0.009907 0 0.014888 0 0 0.000474 0 0 0.023646 0.011116 0 0.019347 7.64E-05 0 0.000553 0 4.73E-05 0 0.004219 0 0.065706 0 0 0.000968 0.006435 2.87E-05 0 0.010351 0 0.019541 0 0 0.000115 0 0 0.006143 0.004204 0.002817 0.006082 0 0 0.003309 0.006778 0.002251 0.017747 0.00599 0 0.004005 0 2.42E-07 0.000537 0.001773 0 0 0.01399 0 0.0101 0 0 0.000844 0.008004 0 0.010046

Wiley-Blackwell and Society for Applied Microbiology Page 182 of 848

ShewanellaMethanospirillum sp. PV-4-30Methylocella hungateiHaloterrigena sp. strainBL2-01 PelodictyonJF-1-01 turkmenicaClostridium phaeoclathratiforme strain DSMHelicobacter sp. 5511-01OhILAs-01 strainBurkholderia acinonychis BU-1-08Yersinia sp. strain CCGE1002-08 pestis Sheeba-30 strain KIM 10-30 0 0.003767 0.008501 0.000169 0.022233 0.004664 0.020942 0.032317 0 0.017363 0.000425 0.001671 0 0.014806 0.000577 0 0.011002 0 0.005035 6.98E-21 0.003695 0 0.002108 0.000757 0 0.007116 0.010735 0.098868 0 0.00218 0 0 0.000152 0 0.010226 0 0.01071 3.80E-16 0.004789 0 0.008469 0.000599 0 0.002833 0.000447 0.232337 2.02E-18 0.005564 0 0.002824 0.002113 0 0.020837 0 0.01869 0.000704 0.007009 3.90E-07 0.006516 0.000488 0 0.019683 0 0.118664 2.57E-05 0.004661 0 0.011491 0.003021 0 0.012787 0 0.02216 For0 0.005555 Peer0 0.000305Review2.13E-11 Only0 0.005869 0 0.06795 1.49E-08 0.003669 0 0.011043 0.001126 0 0.009009 0 0.00931 0.000325 0.007265 6.29E-07 0.026261 0.001868 0.141135 0.015741 0 0.240475 1.54E-14 0.005332 0 0.01685 0.000792 0 0.015295 0 0.016022 0.000157 0.004872 0 0.017104 7.71E-08 0 0.018005 0.012566 0.005881 1.68E-06 0.006839 6.84E-08 0.005567 0.00102 0 0.000699 0 0.037098 0.002333 0.006733 2.18E-05 0 0.003842 0 0.014099 0 0.077401 2.37E-05 0.003975 0 0 1.59E-05 0 0.001792 0.004485 0.022419 0.001952 0.010359 0 0.021332 0.004546 0 0.015302 0 0.068086 1.09E-05 0.003147 0 0.000453 0.002073 0 0.002309 0 0.020384 0 0.00456 0 0.010205 0.000913 0 0.010266 0

Wiley-Blackwell and Society for Applied Microbiology Page 183 of 848

Borrelia afzeliiCampylobacter strain PKo-08Salmonella curvus Saccharomonosporastrainenterica 525.92-01 subsp.Paracoccus enterica viridis Prochlorococcusdenitrificans serovar strain Choleraesuis DSMStaphylococcus PD1222-08 43017-01sp. MIT9215-08Bacillus strain aureus SC-B67-30 megateriumGluconobacter subsp. aureus strain strainoxydans DSM319-08 ED98-08 strain 621H-01 0 0.000104 0 0.018009 0.069692 0.005133 0 0.005219 0.006524 0 0.001541 0 3.57E-11 0.1594 0.020177 0 0 0.00037 0 0 0 2.35E-08 0.351135 0.004982 0 0 0.001919 0 0 0 0.00097 0.434218 0.013989 0.001818 0.001587 0.00426 0 0.000608 0 0.000659 0.257974 0.001386 0 8.13E-05 0.005136 0 0 0.013266 1.64E-13 0.185158 0 0 0 0.00244 0 4.26E-05 0 0.001132 0.150965 0.000431 0 0.003034 0.003158 0 8.37E-05 0 0.000939 0.246791 0 2.62E-07 2.07E-05 0.003803 0 7.48E-05For Peer0 7.87E-05 0.153295Review0.003573 Only0 3.36E-05 0.006066 0 0.001656 0 2.88E-05 0.13384 0 0 0.00222 0.003041 0 0.001932 0 0.000846 0.140167 0.005535 0 0.002011 0.003998 0 1.87E-05 0 0.00067 0.336429 0 0 0 0.005473 0.002567 6.27E-08 0 3.69E-05 0.278616 0 0 0.000697 0.002833 0 0.000645 0 0.00025 0.056436 0.032808 0 0 0.004063 0 0.001474 0.001844 0.001612 0.188025 0.011757 0.001475 0.004897 0.005119 0 1.34E-05 0 0.000442 0.141076 0.021766 0 0.000252 0.004442 0 0.000519 0 0.000438 0.104892 0.002827 0 0 0.002449 0 0.000131 0 1.51E-09 0.278848 0.000883 0 4.92E-05 0 0 0.00056 0.004105 0.003176 0.349241 0.006803 0 0.000582 0.000998

Wiley-Blackwell and Society for Applied Microbiology Page 184 of 848

Rickettsia felisClostridium strain URRWXCal2-01Caulobacter botulinum StaphylococcusB vibrioides strain Eklund AcinetobacterCB15-01 carnosus17B-30Acinetobacter subsp. baumannii carnosusstrainClostridium strainbaumannii ATCCThermococcus perfringens TM300-30 strain 17978-01 AB307-0294-08Proteinoruptor strain onnurineus SM101-08 strainkamchatkensis NA1-08 1221n-08 0.007469 0 0 0 0.001509 0 0.00218 0.0008 0 0.002603 0 0 0 0.000647 0 0 0 0 0.002473 0.002707 0.002227 5.18E-07 0.001967 0 0.000404 0 0 0 0 0 0 0 0.041412 0 0 0 0 0 0 0 0 0 0 0 0 0.004319 0 0 0 0.00601 0 0 0 0 0.003632 0 0.006802 0 0.004066 0 0.002743 2.75E-12 0 0.002611 0 0 0 0.004266 0 0 0 0 0.002391 For0 0.005106 Peer7.31E-05 Review0 0 Only0 0 0 0.002046 0 0.00282 0 0 0 0 0 0 0.00418 0.000429 0.003408 0 0.003103 0 0.000665 0 0 0.00343 0 0.008092 0 0 0 0 0 0 0 0 0 0 0 0.046986 0 0 0 0.004678 0 0.005986 0 0.001919 0.006068 0 0 0 0.002065 0.016472 0 0 0.003099 0 0 2.38E-08 0.006431 0.002773 0 0 0 0 0 0 0.000733 0 0.003221 2.87E-09 0.007929 0.008443 0.004499 0.009783 0 0.001012 0.002753 0.001897 0 0.001906 0 0 0 0 0 0 0.000375 0 0 0.03727 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 185 of 848

SynechococcusSalmonella sp. PCC Sulfolobus enterica7424-30 subsp. islandicusDesulfovibrio enterica strainMethanohalophilus serovarsalexigens M.16.27-08 AgonaAeromonas strain str. DSMmahii SL483-08Methylobacterium hydrophila 2638-30 strain DSMSynechococcus subsp. 5219-08 hydrophilasp. MoorellaBJ001-30 sp. CC9605-08strain thermoacetica ATCC 7966-08 strain ATCC 39073-30 0 0 0 8.20E-05 0.033811 0.020882 0.043254 0.030259 0 0.105164 0 0 0 0 0.048226 0.019414 0.003465 0 0.006817 0.00262 0 0.015226 0 0.021054 0.012276 0.048699 0 0.036427 0.005111 0 0 0 0.054762 0.013236 0.004287 0 0.01854 0.000399 0 0 0.003098 0.017803 0.009257 0.003655 0 0.135599 0 0 0 0 0.084152 0.011427 0.00233 0 0.008634 0 0 0.023477 6.58E-07 0.024541 0.01038 0.001642 0 0.016734 0.003314 0 0 0 0.078277 0.053226 0.015789 0 0.007542 For0 Peer0 9.42E-05 Review0 0.019895 0.002257 Only0.103841 3.63E-06 0.081283 0.001477 0 0 0.001014 0.057334 1.13E-14 0.006293 0 0.007537 0 0 0 0.000287 0.064743 6.12E-10 0.005508 0 0.006523 0.006632 0 0.000168 0 0.072903 8.11E-06 0.04799 0 0.120383 0 0 0 0 0.102095 0.006082 0.001322 0 0.036396 0 0.000317 1.85E-05 0 0.009433 0.00298 0.685434 0 0.0002 0 0 0.013615 0.008304 0.041043 0.005779 0.004351 0 0.020781 0 0 0.007986 0.009667 0.024107 0.009854 0.658324 0.004868 0.01092 0.002569 0 0.018781 0.01691 0.017933 0.009484 0.002858 0.013027 0.013261 0 0 0 0 0.022189 0.000247 0.002751 0 0.024608 0 0 4.55E-05 0 0.082716 0.00027 0.007515 0

Wiley-Blackwell and Society for Applied Microbiology Page 186 of 848

Escherichia bacteriumcoli strain CFT073-08EX-H1-08Geobacter sp.Arthrobacter M21-30 DSM chlorophenolicus 13-08 Yersinia pestisstrainEnterobacter strainA6-08 PestoidesMethanococcus sakazakii F-08Delftia ATCC maripaludis BAA-894-08 acidovorans strain strain S2-08 SPH-1-30 0.008997 0.020655 0.051706 0.006575 0.010176 0 0.004938 0 0.020931 0.008011 0 0.000118 0.001155 0 0 0.001696 0 0.038904 0.005646 0 0.031625 0.005709 0 0 0.002459 0 0.000399 0.012252 0 0 0.000189 0 0 0.00948 0 0.020845 0 0.002284 0.005739 0.000475 0 0 0.00551 0 0.016745 0 0 0.165635 0.001915 0 0 0.015661 0.002645 0.072284 0 0.004706 0.042749 0.006562 0 0 0 0 0.000608 0 0 0.00501 8.49E-05 0 0 0.015274 0 0.031973 0 0.002571For0.008124 Peer8.69E-05 Review0 0 Only0 0 0.003284 0 0.000292 0.003267 0.000589 0.000166 0.018245 0.010949 0 0 0 0.000333 0.092843 0.000248 5.21E-06 0 0.011642 0 0.034592 0.022377 0 0.017878 0.006205 0 0 0 0 0.004083 0 0.001624 0.021071 0.003987 0 0.022344 0.020407 0 0.003807 0 0 9.37E-05 0 0 0 0 0 0.008723 0.013116 0.011379 0.044559 0.003911 0.001047 0 0.007838 0 0.012718 0 0.004503 0.001588 0 8.08E-05 0 0.002473 0.000103 0.003509 0 0.006549 0.018679 0.001154 0.00159 0 0.004071 0 0.005281 0.002335 0 0.002767 0.000352 0 0 0.004425 0 0.001401 0 0.001576 0.03935 0.003259 2.22E-05 0 0.013959 0.001081 9.52E-05

Wiley-Blackwell and Society for Applied Microbiology Page 187 of 848

StaphylococcusOnion haemolyticus yellowsCampylobacter phytoplasma strainBrucella JCSC1435-08 fetus str. ovis 'onionsubsp.Nostoc strain yellows'-01fetus sp. ATCC strainMycoplasmastrain 25840-01 PCC82-40-30 7120-08Klebsiella genitalium pneumoniaeSulfolobus strain G37-30 islandicusMethylobacterium subsp. pneumoniae strain Y.G.57.14-01 extorquens strain MGH strain 78578-30 PA1-01 0 0 0.094328 0 0.003017 0 0 0 0.001744 0.01657 0 0 0 0.011654 0 0 0 0.000943 0 0 0 0.002298 0 0 0 0 0.001757 0 0 0 0 0.004775 0 0.010685 0 0.001545 0 0 0 0 0.003009 0 0 0 0.001189 0 1.29E-05 0 0 0.001637 0 0.137656 0 0.001511 0 0 0 0 0 0 0.008158 0 0.001698 0 0 0 0 0.025794 0 0 0 0.002469 0 For0 Peer0 0.010401 Review0 0 Only0 0 0.001731 0 0 0 0 0.008515 0 0.002334 0 0.000875 0 0.00332 0 0.007167 0.004242 0 0 0 0.001719 0 0 0 0 0.011022 0 0.026859 0 0.001627 0.00382 0 0 0 0 0 0.01257 0 0 0 0 0 0 0.004231 0.095669 0.001766 0 0.002874 0 0 0 0 0.005518 0 0 0 0.002703 0 0 0 0 0.009313 0 0.002976 0 0.001875 0.003058 8.82E-16 0 0 0.002579 0 5.05E-05 6.23E-08 0.001534 0 0 0 0 0.004099 0 0.003315 0 0.000554 0 0 0 0 0.005755 0 0.006145 0 0.001662

Wiley-Blackwell and Society for Applied Microbiology Page 188 of 848

ProchlorococcusSphaerobacter sp. MIT9313-08Desulfobacterium thermophilusAcidithiobacillus strainautotrophicumCorynebacterium DSM ferrooxidans 20745-30 Bacillusstrain HRM2-08urealyticum str.thuringiensis methanogenicATCC 23270-08 strain serovarBartonella DSM archaeon konkukian 7109-01 grahamiiPorphyromonas strain strain SANAE-08 strain 97-27-30 as4aup-30 gingivalis strain ATCC 33277-08 0.0849 0.112217 0.027435 0 0.000168 0 0.035726 0 0 0.007792 0 0.000121 0.006396 0 0.007678 0.002528 0 0.035482 0.041864 0 0.001052 0 7.06E-12 9.04E-05 0 2.59E-05 0.037276 0 9.95E-07 0.006483 0.002997 1.16E-08 0 0 0.00971 0 3.03E-05 1.17E-05 0.002851 0.001968 3.61E-08 0 0 0.012382 0.020463 0.000668 0 0.01215 0.024039 0 4.88E-05 0.006198 0 0.015031 0.00288 0.023119 0.01327 0.010045 5.80E-05 0 0 0.007283 0 0 0 0.0114 0 0 0 0 0 0.061069 0.020468 For0 0.003939 Peer0.013233 Review0 0 Only0 0 0 0.004174 4.51E-06 0.003893 0.018257 0 0.000512 0 0 0.016606 0.004834 0 0.011914 0 0.00011 0 0 0 0.015216 0 0.029213 0.009229 0.004732 0 1.98E-05 0 1.27E-17 0.00189 0.008774 0 0.009583 0.035763 0 0 0 0.00548 0 0.067128 4.49E-05 0.000954 0 0 0 0 6.23E-05 0 0 0.010181 0.034244 0 9.86E-05 0 0.00559 0 0.019683 0.060685 0.00014 0.008365 0.003558 0 0 0.002333 0 0.011874 0.02288 0.034723 0.012575 0 0 0.00103 0.006119 0.01185 0 0 0 0.011655 0.010774 2.49E-13 0 0 0.049029 0 0.004353 0 0.020708 0.034563 7.10E-07 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 189 of 848

StaphylococcusNeisseria aureus meningitidisChromohalobacter subsp. aureus Candidatusserogroup Mu50-30 salexigens A LeptospiraHamiltonella strain strainZ2491-30 borgpeterseniiPirellula DSMdefensa 3043-01 staleyi strainCandidatus serovar strain 5AT (AcyrthosiphonDSM ErwiniaDesulforudisHardjo-bovis 6068-30 amylovoraThioalkalivibrio audaxviatorstrain pisum)-08 strain JB197-01 ATCC strain sp. HL-EbGR7-3049946-30 MP104C-30 0 0.044482 0.029287 3.23E-05 0 0.773228 0 0 0.017603 0 0 0.009561 0.00075 0 0.064292 0 0 0.354425 0 0 0.023398 0.008211 0 0.028521 0 0 0.068142 0 0 0.064137 0.009604 2.99E-05 0.008474 0 0 0.303028 0 0.022509 0.03336 0.008811 0.000775 0.008451 0 0 0.030249 0 0 0.0801 0 0.002722 0 0 0.025036 0.183407 0 0 0.046661 1.50E-07 0 0.117049 0 0.000683 0.125269 0 0.001972 0.061829 0.00743 0.000856 3.37E-09 0 0 0.351167 0 For0 0.032809 Peer0.001466 Review0 0.052844 Only0 0 0.117111 0 0.005752 0.055632 0.008363 0 1.40E-13 0 0.000567 0.080393 0.075708 0.025517 0.042356 0.005634 0 0.035478 0 3.48E-11 0.3287 0 0 0.052197 5.55E-09 0.000226 0.026307 0 0 0.127762 0 0 0.151011 0.014796 0.001149 2.61E-10 0 0 0.12605 0 0 0.014386 0.006446 0 0.042722 0 0 0.026847 0.019522 0 0.029871 0.005123 0.002728 0.314626 3.50E-05 0.007578 0.75176 0 0.01367 0.020038 0.001085 0 0.340055 5.71E-13 0.004925 0.046131 0.003694 0.001836 0.05618 0.00557 0 0.30931 0.029382 0.000508 0.138047 0 0 0.013737 0.002033 0 0 0 0.04775 0.124596 0 0.014621 0.130909 0.025081 0.000308 4.25E-05 0 0 0.1086

Wiley-Blackwell and Society for Applied Microbiology Page 190 of 848

RobiginitaleaAkkermansia biformataTreponema strain sp. Muc-01 HTCC2501-30Bacillus pallidum cytotoxis subsp.Dictyoglomus pallidum NVH Anaerococcus391-98-01 thermophilum str. Nichols-01Salmonella prevotii H-6-12-30 Proteinoruptorstraintyphimurium DSM Lactobacillus20548-08 LT2-08 kamchatkensis paracasei 1221n-01 ATCC 334-01 0.497818 0.022198 9.63E-05 0.000392 0 0 6.44E-11 2.98E-16 0 1.086637 6.97E-10 0 2.88E-06 0 0 0 0 0 2.500016 0.000852 0 8.51E-10 0 0 0.002196 0 0 1.23335 0.0031 0 0 0 0 0 0 0 1.479788 0.000143 0 0.000178 0 0 6.71E-18 0 0 0.47688 0.001349 0 0.000876 0 0 0 0 0 0.927149 0.00032 0 0.001056 0 0 0 0 0 0.96354 0.001407 0 1.14E-09 0 0 0.001952 0 0 0.953988 0.000335For Peer0 3.46E-05 0.018409Review0 Only0 0 0 2.336166 9.70E-06 0 0.001637 0 0 0 1.27E-30 0 1.026876 0.000139 0 0.001705 0 0 0.005027 0.002076 3.35E-06 1.190361 0.004214 0.000274 0 0 0 0 0 0 3.056641 0.001718 0 0.001342 0 0.006445 0 0 0 0.802687 0.004807 0 0 0 0 0 0 0 0.844208 0.003233 0 0.00073 0 0.001508 0 1.10E-06 0 0.855336 0.001988 0 0.000284 0 0.001496 0 0 0 0.741692 0.001039 0 3.13E-05 0.019242 0.002097 0 1.02E-22 0 0.750415 9.82E-08 0 0.000571 0 0 0 0 0 2.188384 0.002142 0 0.001113 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 191 of 848

StaphylothermusRoseiflexus marinusYersinia sp. strain pestis F1-01RS-1-08Methanosarcina strain CO92-01uncultured mazei Clostridium Termitestrain Go1-01 groupPseudomonas difficile 1 bacterium strainYersinia sp.630-30 phylotype LB400-08 pseudotuberculosisGranulobacter Rs-D17-30 bethesdensis strain IP 32953-08 CGDNIH1-30 5.19E-17 0.029878 0 7.34E-05 0 0.013936 0.015137 0.001187 0 0 0.003128 0 0 0 0 0.004382 0 0.041617 0 0.002302 0 0 0 3.08E-05 0.002334 0 0.00816 0 0.003593 0 0 0 0.000821 0.002531 0 0.033863 0 0.000103 0 0 0 0.000566 0.005409 0 0.021478 0 1.72E-06 0.005267 2.06E-05 0 0.090076 0.007844 0 0.016332 0 0.002903 0 8.74E-05 0 0 0.0031 0.006686 0.004127 1.01E-17 0.004125 0 1.36E-06 0 0.034113 0.007233 0.012807 5.91E-09 0 0.000702For Peer0 1.27E-05 Review0 0.005173 0.003381 Only0.002879 0.045849 0 0.003616 0 3.35E-09 0 0.000717 0.009431 0.009813 1.10E-22 0 0.001068 0 0.000439 0 0.0018 0.006054 0 4.33E-06 0 0.002193 0 0.00066 0 0.002087 0.012561 0 0.001696 0 0.003421 0 0 0 0.000604 0.011358 0 3.57E-09 0 0.001234 0 0.000653 0 5.44E-05 0.002137 0 0.026296 2.78E-06 0.00579 0 0.000162 0 0.001135 0.012949 0 0.041885 0 0.002375 0.000437 0 0 0.002107 0.00405 0.000121 0.021439 0.000119 0.008833 0 0.000846 0.012871 0.004328 0.00281 0 0.003342 0 0.001832 0 2.35E-08 0 0 0.001937 0 0.052571 0 0.002567 0 2.16E-09 0 0.000426 0.013874 0.002242 0

Wiley-Blackwell and Society for Applied Microbiology Page 192 of 848

MethanothrixParvibaculum thermophilaCaulobacter lavamentivorans PT-08 Sinorhizobium segnis strain strainKlebsiella ATCC medicaeDS-1-30 21756-01 pneumoniaePseudobacterium WSM419-01Xylella subsp. sepedonicum-08 fastidiosapneumoniaeShewanella strain strainLactobacillus sediminisM12-08 MGH 78578-01strain crispatus HAW-EB3-30 strain ST1-01 0.028851 0.155979 0.008157 0.022334 0.000246 0.001213 0.007468 0 0 0 0.009414 0.001773 0.005187 0.000245 0.00682 0.006888 0 0 0 0.083527 0.002072 0.009092 0.0003 0 0.003528 0.023483 0 0 0.108488 0.005954 0.012033 0 0 0.001024 0.146038 0 0 0.104973 0.004795 0.00772 0 9.45E-12 0.001104 0.016795 0.001339 0 0 0.003243 0.016449 0 0.000256 0.004061 0.16639 0 0.006278 0.064281 0.004164 0.013285 0 0.001916 0.004214 0.00893 0 0 0.126009 0.006966 0.015431 0 0.012044 0.011043 0.153306 0 0.003808 0.06122For0.006102 Peer0.009285 0.000302Review4.79E-08 0.004215 Only0.058215 0 0 0.00013 0.000985 0.010748 0 0 0.00475 0.029845 0 0 0.055129 0.002523 0.013099 0 5.29E-05 0.006353 0.124354 0 0 0.069407 0.003525 0.009197 0 0 0 0.166622 0 0 0.003366 0.003909 0.01982 0 0 0.00863 0.093434 0 0.003065 0.070509 0.005191 0.010259 0 0.000895 0.001115 0.009461 0 0.001259 0.123508 0.003948 0.006756 0.001001 0.00072 0 0.030539 0 6.48E-05 0.055885 0.005025 0.007153 0.000264 0.000696 0.002494 0.048039 0.001281 0.003818 0.115952 0.006463 0.013077 0 0.00056 0.004949 0.020929 0 0 0.012853 0.002221 0.006108 0.00016 0.003124 0.003154 0.03497 0 0 0.044503 0.002156 0.018329 0 0.000101 0.011786 0.027993 0

Wiley-Blackwell and Society for Applied Microbiology Page 193 of 848

PyrobaculumStaphylococcus arsenaticumDesulfovibrio strainaureus DSMArthrobacter subsp. desulfuricans 13514-01 aureusEggerthella sp. COL-08 subsp.FB24-01 Desulfotomaculum lentadesulfuricans strainXanthomonas DSM strain 2243-30 reducens ATCCBordetella axonopodis 27774-01 strain petriiWolinella MI-1-01 pv. strain citri succinogenes DSMstr. 306-30 12804-01 strain DSM 1740-08 0 0.011638 0.003643 0.000428 0 0.008662 0.00031 0.006903 0.000994 0 0 0.001092 0.000152 0 2.43E-05 0 0.003942 0 0 6.92E-11 0.003162 0.000111 2.46E-05 1.31E-05 0.001407 0.002897 0 0 0 0 0 0 3.27E-06 0.012492 0.005163 0.01134 0 0 7.18E-07 3.76E-05 7.22E-06 4.96E-06 0.009591 0.003796 0.004473 0 0 0.003464 0.000138 0 0.000887 0.073886 0.005855 0 0 0 0.001341 0 0.009646 0.003242 0.011323 0.00902 0.001177 0 0 0.009153 1.52E-05 0 4.64E-05 0.09353 0.00513 0.021844 0 For0 0.000991 Peer7.71E-06 Review0 0 0.014036 Only0.005685 0.00496 0 0 0.001906 0.000167 0.033899 0.00015 0.001728 0.006885 0.00406 6.73E-06 0 0.001403 0.000166 0 2.64E-05 0.08525 0.005693 0 0 0 0.00097 0.00031 0 0.001593 0.009431 0.002409 0 0 0 0.000982 0.000119 0 0.002099 0.004948 0.010721 0.008287 0 0 0.001482 0.000216 0.000529 0.00126 0.00138 0.00571 0 0 0 0.003787 0.000242 0 0.000624 0.016391 0.009819 0.02433 0 0.001524 1.45E-06 1.75E-05 0 0.000643 0.010403 0.00181 0.000228 3.15E-06 0 0.00319 0.000933 0.004694 0.001068 0.006031 0.008785 0.006764 0 0 1.22E-05 2.48E-11 0 0 0.000932 0.000687 0 0 0 0.000768 0.000706 0 0.000141 0.002208 0.007556 0.018058

Wiley-Blackwell and Society for Applied Microbiology Page 194 of 848

MycoplasmaThermotoga pneumoniaePhytoplasma maritima strain M129-30 strainMethanobrevibacter solani MSB8-01 australensis-01Nitrosomonas ruminantiumBurkholderia europaeaStaphylococcus strain str.multivorans ATCC M1-08 Gordonia19718-01 strain aureus ATCCbronchialisLeptospira subsp. 17616-30 aureus strain biflexa strain DSM serovar MRSA252-0843247-08 Patoc strain Patoc1-01 0 0 0 0.002325 0.022206 0 1.99E-17 0.000343 0.009534 0 0 0 0 0.002425 0.029206 0 0 0 0 0 2.60E-09 7.38E-08 0.00982 5.51E-05 0 0 0 0 0 0 0 0.005956 0.000336 0 0.006252 0.004145 0 0 0 0 0.00345 0.005028 0 0.001039 0.000805 0.484226 0 0 0 0.015146 0.026753 0 0 0.002261 0 0.0016 7.24E-08 0 0.037242 1.68E-05 0 0.000223 0.003108 0 0 0 0 0.01278 0.035191 0 0.000285 0 0 For0 Peer0 0 0.00457Review0.004149 Only0 0.004076 0 0 8.40E-09 0 0 0.007819 0.008144 0 0.000167 4.45E-07 0 3.76E-09 0.00083 0 0.01875 0.008621 0 0.000108 0.00114 0 0 0 0 0.001702 2.85E-05 0 0.000108 0 0 0 4.58E-12 0.008771 0.014967 0.00746 0 0.00273 0 0 0 0 1.69E-05 0.003257 0.003968 0 0.000202 0.001593 0 0 1.93E-06 0.000389 0.082278 0.006096 0 0.000594 0 0 7.03E-06 0 0.000145 0.004 0.00342 0 0.000426 0.001423 0.028254 0.000526 9.70E-14 4.91E-07 0.074153 0.00318 0 0.003341 0 0 0 1.92E-07 0 0.001662 0.010577 0 6.11E-06 0 0 0 0 9.23E-06 0.005335 0.002264 0 3.41E-06 0.002044

Wiley-Blackwell and Society for Applied Microbiology Page 195 of 848

SalinibacterMethylobacillus ruber AntonStreptococcus et al.flagellatus 2002-01Xanthomonas equi strain subsp. KT-01Xylanimonas campestris equi strainNitrobacter cellulosilytica pv. 4047-30 campestrisPsychrobacter hamburgensis strain str. ATCCDSMShewanella sp. strain 15894-0833913-08 273-4-01 X14-30Methanohalophilus frigidimarina strain mahiiNCIMB strain 400-30 DSM 5219-30 0.008843 0.014425 0 0.011487 6.02E-10 0.047504 0.002721 0 0 0.000286 0.020276 0 0.0064 9.99E-08 0 0.003625 0.041825 0 0.000609 0.028864 0 0.003246 0.002078 0.002052 0.00295 0.023288 0 0 0.034678 0 0.003327 0 0.011671 0.004396 0.263418 0 0.00035 0.030639 0 0.00356 5.60E-17 0.025664 0.009154 0.086755 0.00265 0.000852 0.064053 0 0.0071 0 0 0.009731 0.549284 0 0.000891 0.088281 0 0.006664 1.96E-13 0.003224 0.010727 0.077947 1.25E-05 1.48E-05 0.049285 0 0.008844 0 0 0.010734 0 0 7.26E-08 0.055922For Peer0 0.000486 0.003295Review0.016659 0.004149 Only0.260636 0 0.000411 0.036882 0 0.003786 0 0.00233 0 0.013224 0 0.001008 0.035945 0 0.005474 0.002571 0.006843 0.009379 0.06745 0 0.000943 0.032661 0 0.00152 0 0.016335 0.011578 0.876067 0 1.55E-07 0.039919 0.035682 0.008057 0.000881 0.018245 0.018006 0.024231 0 4.56E-05 0.037929 0 0.004681 0.000751 0.001204 0.005198 0.059298 0 4.75E-05 0.062992 0 0.004944 0.016797 0.017127 0.008311 0.135296 0.03996 0.001211 0.02605 0 0.000844 0.000579 0.007478 0.001767 0.402221 0.001791 0.000808 0.073163 0 0.005417 0.00424 0.032565 0.010169 0.033675 0 4.01E-06 0.022912 0.045843 0.002533 3.80E-16 1.93E-05 0.004141 0.982758 0 0.000456 0.071628 0.018063 0.009998 0 9.75E-05 0.013544 0.068996 0

Wiley-Blackwell and Society for Applied Microbiology Page 196 of 848

Brucella canisAcidithiobacillus strain ATCCHalorhodospira 23365-08 ferrooxidansSynechococcus halophila str. FibrobacterATCC strain sp. 23270-01 PCC7002-01 SL1-30Nitrobacter succinogenesCorynebacterium winogradskyi subsp. succinogenesChromobacterium strain diphtheriae Nb-255-01Geobacter S85-01 violaceumNCTC13129-30 sulfurreducens str. ATCC strain 12472-30 PCA-01 0 0.016988 0.034061 0.003311 0.001525 0.015908 0 0 0.027587 0 0.002477 0 0.015644 0.001876 0.003453 0.082814 0 0.000996 0 0.003359 0.004169 0.005342 1.81E-06 0.003255 0.003712 0.056232 1.76E-06 0 0.003598 0.201443 0.000816 0 0.0046 0 0.02937 0.00057 0 0.005512 0.016769 0.001348 0.000669 0.004213 0 0.000837 0.000266 0 0 0.008079 0.008405 0.001422 0.003411 0 0.027321 0.000995 0 0.009729 0.014108 0.00205 0.000128 0.005844 0 0.039969 0.002234 0 0 1.43E-05 0.003803 5.94E-05 0.004688 0 0 0.002264 0 0.003517For0.022905 Peer0.000676 Review0 0.007029 Only0 0.009993 0.000188 0 0.01018 0.003323 0.00353 0.000746 0.003937 0 0.025932 0.000324 0.016362 0.011845 0.035418 0.003495 0.000803 0.00343 0 0.00177 0.001973 0.046965 0 0.000407 0.002944 9.03E-05 0.005582 1.61E-20 0.005473 0.000202 0 0 0.030197 0.000337 0.000356 0.002928 0 0.008152 0.000557 0 0.004663 0.002829 0.007993 0.000678 0.011219 0 0.005437 0.001078 0 0 0.192612 0.003316 0.003359 0.006161 0.009623 0.021474 0.00614 0 0.001118 0.009183 0.001309 4.29E-06 0.007828 0 0.009129 7.47E-05 0 0.009699 0.07591 0.002607 0.001118 0.007324 0 0.00939 0.006134 0 0.000677 0.003346 0.000881 1.80E-05 0.002688 0 0.001529 2.32E-05 0.040948 0.004812 0.09838 0.002166 1.62E-06 0.001178 0 0.001859 0.000485

Wiley-Blackwell and Society for Applied Microbiology Page 197 of 848

BrevibacillusMarinomonas brevis strainHaemophilus sp.NBRC MWYL1-08 100599-08Escherichia influenzae Bacilluscoli strain O103:H2 cereusPittEE-08Halobacterium strain strain 12009-01 AH187-30Yersinia salinarum pseudotuberculosisepsilon strain proteobacterium R1-01gamma strain proteobacterium IP AmH-08 31758-08 MLHE-1-01 0.004947 0.070892 0 0.000982 0 0 0 0.042381 0.05771 1.24E-06 1.499901 0.080148 0 0.005909 0 0.015057 0.020736 0.002129 0.000749 0.257774 0.007244 0 0.000509 0 0.00412 0.004421 0.009113 2.40E-05 0.855711 0 0.000736 0 0 0 0 0.013004 0.000671 0.227366 0 0 0.000573 0 0 0 0.009052 0.003414 1.714511 0 0 0 0 0 0.000397 0.021317 0.002813 0.316151 0.015409 0 0 0 0 0.007299 0.029486 0.002273 1.792423 0.00698 0 0 0 0 0.00544 0.021168 0.001258 0.152513For Peer0 0.000667 Review0 0 Only0 9.50E-17 0.014881 0.002129 1.259235 0.027749 0.000435 0.000704 0 0.015651 0.001889 0.009306 0.000425 1.713838 0.017898 0.000875 0 0 0.009819 9.40E-05 0.013123 5.72E-05 0.645861 0.036561 0.000396 1.78E-05 0 0 0.044971 0.01409 0.001026 1.773258 0.068043 0 0 0 0.011606 0.002661 0.036878 0.00285 0.050567 0.002635 0.00029 0 3.31E-05 0 0.008019 0.008301 0.001969 0.370324 0.035344 0.000581 0 1.65E-06 0.014251 0.016095 0.027276 0.000353 0.183189 0.005815 0 0 0 0 0.0032 0.010043 0.005515 0.290534 0 0.000687 0.001911 0 0 0.012606 0.027939 0.000303 0.433562 0.019517 0 0 0 0 0.000639 0.005025 0.003803 1.644504 0.022718 0 0 0 0.005693 0 0.027883

Wiley-Blackwell and Society for Applied Microbiology Page 198 of 848

Tolumonas Bacillusauensis cytotoxisstrainRoseiflexus DSM NVH 9187-08 Hahella 391-98-08castenholzii chejuensisMethanocorpusculum strain strainDSMThermococcus 13941-30 KCTC 2396-01 Clostridiumlabreanum gammatolerans Prochlorococcusstrain difficile Z-01 strainTreponema EJ3-30R20291-30 sp. AS9601-30 denticola str. ATCC 35405-01 0 0.005805 0.032638 0.042898 0.002743 0 0.437648 0 0.010032 0.067895 0.000679 0.071521 0.012932 0 0 0.641516 0.281774 1.23E-21 0.020628 0.000164 1.96E-09 0.020571 0 0 0 0.027389 3.87E-22 0.054723 0 0.00391 0.056756 0 0 0 0 1.56E-25 0.021745 0.00017 0.007992 0.022693 0 0 0 0 0 0.116975 0.002376 0 0.055974 0 0.08701 0.319447 0 7.55E-27 0.049743 0.000572 0.004354 0.048573 0.000492 5.53E-11 0.157234 0 1.22E-34 0.078074 0 8.19E-06 0.046996 1.94E-05 0 0.399517 0.07591 0.00125 0.037465 For0 Peer0 0.02852 Review0 0 0.037946 Only 0 0 0.070075 0.003703 0.021167 0.03445 0.000103 0 0 0.024627 2.90E-30 0.076676 2.20E-18 0.014999 0.025488 5.69E-11 0 0 0.006277 0.000121 0.063439 0 0 0.04306 0.000639 0 0.172455 0 0.000877 0.156684 0.004231 3.99E-10 0.126981 0 0 0.210633 0.035727 8.55E-25 0.008205 0 0.009727 0.017745 1.04E-06 0 0 0 0.000175 0.055208 0 0.010294 0.037373 0.000183 1.12E-27 0.106121 0 9.06E-09 0.041111 3.94E-06 4.41E-06 0.012961 0 0 0 0.023835 6.97E-27 0.050243 4.09E-05 0.012007 0.052166 0.000229 2.18E-10 0.049533 0.034991 0.003549 0.05474 0 0.002332 0.007985 0 0 0 0 1.15E-18 0.098769 0 0.047772 0.106425 0 0 0.114704 0 3.99E-24

Wiley-Blackwell and Society for Applied Microbiology Page 199 of 848

JannaschinaClostridium sp. CCS1-30Mycobacterium phytofermentansSilicibacter marinum strain Streptococcussp. ISDg-30 strainTM1040-01 M-01Clostridium mutans Candidatusstr. difficile UA159-01 strain ChlorobiumAccumulibactor 630-08 Burkholderia limicola phosphatis strain pseudomallei DSM Type 245-30 IIA str. strain UW-1-01 K96243-01 0.077371 0 0.000508 0.034768 0 0.010223 0.011325 0.082477 0.000166 0.27202 0 0 0.037741 0 0.007659 0.001148 3.29E-05 9.40E-05 0.500206 0.000897 4.06E-06 0.090602 0 0.000238 0.001105 0.018342 0.000192 2.613723 0 0 0.632083 0 0 0.001357 0.094519 3.50E-06 1.266612 0 0.000283 0.239925 0 0.000104 0.002464 0.057003 0 0.817899 0 0.000145 0.205653 1.52E-06 0 0.005501 7.15E-07 0.000303 0.301274 0 0.000267 0.134914 0 0 0.010205 0.031643 0.000263 0.730122 0 1.17E-05 0.191952 0 3.88E-07 0.004653 0 0.000641 0.332156 For0 7.69E-06 Peer0.249871 Review0 0 0.001773 Only0.014947 0 0.686328 0 0 0.166594 0 4.74E-10 0.004642 0.020151 0.000292 0.653327 0 5.17E-05 0.11928 0 0 0.006646 0.079548 0.000298 0.326315 0.000748 3.00E-05 0.337546 0 0 0.00312 0.017436 2.79E-17 0.700483 0.001673 0.000668 0.515204 0 0.001572 0.005761 0 0.000829 0.120768 0 0.000236 0.229688 0 0.001677 0.00186 0.020248 4.58E-09 0.297941 2.21E-13 1.05E-05 0.099493 0 0 0.008062 0.016252 0.000331 0.324203 0 0.000295 0.216489 0 0 0.001204 0.001349 8.75E-13 0.260194 3.26E-05 0.000498 0.095676 0 0.006454 0.006364 0.030942 0.000778 0.965244 0 4.41E-08 0.123313 0 0 0.001833 0 4.67E-05 0.498345 1.86E-10 0.000563 0.582535 0 0 0.008627 0.009125 0.000375

Wiley-Blackwell and Society for Applied Microbiology Page 200 of 848

Listeria monocytogenesDeinococcusBacillus straindeserti 08-5578-30anthracis strainCitrobacter VCD115-08 strain Lysinibacillusrodentium A0248-01 Nitrosospirastrain sphaericus ICC168-30Rhizobium multiformis strain C3-41-30 leguminosarumProchlorococcus strain ATCCAcinetobacter 25196-08 bv. sp. viciae MIT9215-01 baumanniistr. 3841-01 strain AYE-30 0 0.012287 0 0 0 0.086101 0.005177 0 0 0 0 0 0 1.111717 0.010398 0.000563 0.000921 0 0 0.003417 0 0.00263 0.046533 0.010067 0.001536 0.004105 0 0 8.94E-05 0 0.044031 0 0.010184 0.002006 0 0.045706 0 0.002549 0 0.000867 0.019425 0.011917 0.002837 0.001587 0 0 0.005463 0 0 2.490986 0.047311 0.002715 0.003501 0 0 0.009094 0 0.000913 0.05759 0.155388 0.002595 0.002367 0 0 3.93E-06 1.23E-05 0.087011 2.047931 0.052392 0.003634 0.008326 0 0 2.73E-05For Peer0 0.005347 0.047783Review0.003107 0.002862 Only0.001466 0 0 3.87E-05 0 2.15E-10 0.332269 0.021569 0.001484 0.004493 0.042471 0 0.001376 0 0 1.186429 0.033553 0.002558 0.008023 0 0 0.019537 0 0.027614 0 0.046761 0.003539 0.000312 0 0 0.004727 0 0.000974 0.418346 0.044241 0.004482 0.007172 0 0 0.003822 0 0.010193 0.069118 0.004371 0.000946 0.003247 0.010258 0.000815 0.014429 0 0.008093 0.002148 0.304729 0.004068 0.009355 0 0.00054 0.002706 0 0.002403 0.030087 0.00786 0.001749 0.00427 0.025047 0 0.003454 0 0.002722 0.024454 0.219232 0.00291 0.003618 0.005206 0 0.000168 0 0 0.305256 0 0.000727 0.004036 0 0 0.002215 0 0.026892 0.32889 0.033723 0.004936 0.002988 0.038361

Wiley-Blackwell and Society for Applied Microbiology Page 201 of 848

XanthomonasMycobacterium campestrisPsychrobacter pv. tuberculosis campestrisgas sp.vacuolate strain273-4-30str. ATCCMycobacterium F11-01 str. 33913-30 37-08Brucella bovis melitensis BCGXylanimonas strain str. PasteurCoxiella ATCC cellulosilytica 23456-30 1173P2-08 burnetiiLactococcus strain strain DSM RSA lactis 331-3015894-01 subsp. cremoris strain SK11-08 0.126549 0 0.431397 0.063737 0 0 0.000214 0 0 0.136601 0.000122 0.154426 0.195579 0 0 2.26E-18 0 0 0.042639 0 0.037596 0.074778 0 0.009353 2.66E-06 0 0 0.00246 0 0 0.171632 0 0 3.94E-07 0 0 0.0293 0 0.039037 0.087681 0 0.00785 3.18E-05 0 0.001111 0.051228 0 0.141475 0.313574 0 0 3.90E-08 0 0 0.022651 0 0.008098 0.093731 0 0 0.000861 0 0 0.131232 0 0 0.219767 0 0 1.95E-05 0 0 0.017691 For0 Peer0 0.044501 Review0 0 6.47E-05 Only 0 0 0.080339 0 0 0.153776 0 0 1.59E-06 0 0 0.118138 0 0.019078 0.208012 0 0 4.30E-05 0 0 0.011118 0 0.05237 0.103363 0 0 1.44E-05 0 0 0.026381 0 0.00522 0.312268 0 0 4.45E-12 0 0.000557 0.013751 4.42E-05 0 0.017312 0 0 3.35E-05 0.000821 0 0.035034 0 0.029693 0.219285 0 0 0.000418 0 0 0.014166 0 0.069256 0.059962 0 0 2.01E-11 0 0 0.015329 0 0.03303 0.170684 0.01491 0.007538 0.000248 0 0 0.011906 0 0 0.126607 0 0 1.91E-07 0 0 0.010937 0 0.013286 0.259981 0 0 0.002039 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 202 of 848

ChloroflexusShewanella aggregansStreptococcus balticastrain DSM strainMycobacterium 9485-08 OS185-01dysgalactiaeClostridium subsp.tuberculosisMethylovorus equisimilisthermocellum CSU#93-01 Desulfovibriostrain sp. strain SIP3-4-08GGS_124-01 ATCCCampylobacter vulgaris 27405-08 subsp.Staphylococcus jejuni vulgaris strain DP4-30 saprophyticus RM1221-08 subsp. saprophyticus strain ATCC 15305-01 0.026744 0.001316 0 0.000817 0.014718 0 0 0 0 0 0 0 0.000123 0.010686 0.031234 0 0 0 0.002941 0.001248 0 0 0.001907 0.043935 0 0 2.14E-11 3.41E-05 0.002841 0 0 2.88E-12 0.020446 1.30E-09 0 0 0.000336 0.001688 1.99E-05 0 6.34E-10 0.035355 0 0 0 1.47E-05 0.003413 0 0 0.005719 0.087928 0 0 0 0.011385 0.002242 2.57E-05 0.000199 0.001314 0.048238 0.003604 0 0 0.002689 0.003601 0 0 0.002199 0.079943 0 0 0 0.003121 0.000824For Peer0 0 2.90E-09Review0.042046 0.006124 Only 0 0 0.004549 0.002551 0 1.93E-05 1.18E-07 0.062054 0 7.31E-10 0 0.000816 0 0 0 0.002886 0.051225 0.001323 0 0.001099 0.006727 0.001542 0 0 0 0.024443 0 0 0 0.002802 0.004673 0 0 0.00244 0.068741 0 0 0 0.002418 0 0 0.000189 0 0.019196 0 0 2.18E-05 0.005514 0 0.002358 0.000464 0.006818 0.070722 0.001378 0 0.000127 0.001005 0.001549 0 0 0.000771 0.019419 6.15E-05 0 0 0.017421 0.00312 0.00074 2.86E-05 0.012558 0.061139 0.014184 0.006412 0 0.00011 0.000747 0 0 0 0 0.013606 0 0 0.00363 0.004089 0 0 0.000239 0.092683 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 203 of 848

GloeobacterZymomonas violaceus Brucellastrain mobilis PCC melitensis subsp. 7421-30Clostridium mobilis biovarProteus thermocellum strain Abortus ZM4-08mirabilisPseudomonas strain strain strain 2308-08 ATCCRhodothermus HI4320-01 sp. 27405-01 LB400-30Novosphingobium marinusBordetella strain aromaticivoransDSM avium 4252-08 strain 197N-08strain DSM 12444-30 0 0.077228 0 0.005201 0.004002 1.25E-05 0.204406 0.207027 0.02779 0.023884 0 0 0 0.001113 0 0.001082 0.092218 0.005902 0.002955 0 0 0.000221 0.001828 0.019938 0.003767 0.026027 0.01495 0.007794 0 0 0 0.0015 0.008403 0.000506 0.009548 0.016839 0.014971 0.003301 0 0.000753 0 0.007965 0.004565 0.007674 0.013482 0.027162 0.004561 0.034547 5.21E-05 0.005277 0.087628 0.022057 7.76E-06 0.019518 0.058449 0 0 0.001017 0.005088 0.010454 0.075133 0.043698 0.009616 0.012814 0.026331 0 8.38E-05 0.002416 0.050692 0.02707 0.665979 0.008781 0.002223 For0 Peer0 2.65E-05 0.004185Review0.008226 0.006336 Only0.013326 0.014167 0.03839 0 0 9.71E-05 0.00216 0.000181 0.013164 0 0.024544 0 0 0 0.000663 0.003382 6.14E-05 0.023852 0.055196 0.019929 0.029571 0.061632 0 0.000153 0.005917 0.017997 0.00037 0.017344 0.015306 0.014299 0 0 0.000281 0.006499 0 0.017868 0.023535 0.041108 0.02534 0 0 0.00076 0.002873 0.008291 0.019693 0.021945 0 0.011821 0 0 0.000801 0.002808 0.01749 0.060473 0.032512 0.015893 0.004755 0.01001 0 0 0.003733 0.005622 0.011262 0.020017 0.008417 0.005219 0.038838 0 0.000922 0.007325 0.006533 0.053398 0.013306 0.010032 0.050723 0.004098 0 1.45E-05 0.001041 0.012582 0.00795 0.03486 0.011725 0.019944 0 0 2.48E-07 0.007382 0.02327 0.011134 0.008272 0.028592

Wiley-Blackwell and Society for Applied Microbiology Page 204 of 848

ZunongwangiaChlorobium profundaMinibacterium phaeobacteroides strain SM-A87-30Candidatus massiliensis-30 strain ThermotogaDesulforudis BS1-01 Acinetobacter neapolitana audaxviatorBartonella NS-E-30 baumanniistrain MP104C-01 quintanaAzospirillum strain strainSDF-30Stackebrandtia sp. Toulouse-30 B510-01 nassauensis strain DSM 44728-30 0.382514 0.025752 0 0.01627 0 0.263682 0 0.07759 0 0.808289 0.003407 0 0 0 3.6485 0 0.005256 0.059831 2.411434 0.000183 0 0 0 0 1.14E-05 0.006712 2.54E-05 1.123449 0.000188 0.017634 4.90E-16 0 0.794193 0 0.004089 0.019477 1.030473 0.002084 0.012811 0.000853 0 0 0.009393 0.007318 0 0.262994 0.000769 0.009507 1.53E-07 0 1.740478 0 0.010427 0.054813 0.584617 0.002494 0 0.000166 0 0.586279 0.011444 0.028212 0.002319 0.924653 0.004793 0.012453 0 0 4.822292 0 0.009968 0.144204 0.799576 0.001297For0.030892 Peer0.000144 Review0 0.249872 Only0 0.013224 0 2.272054 0.001788 0.043065 0 0 1.473632 6.43E-08 0.008468 0.045407 1.28534 0.001416 0.054517 1.01E-05 0 0 0 0.011568 0.090805 1.142435 0.000924 0.047347 0.000554 0 0.471868 9.02E-16 0.011649 0.000321 2.50009 0.003206 0.036799 0 0 1.09826 0.012303 0.009559 0.029553 0.387304 0.0023 0 2.56E-08 0 0.887414 1.16E-11 0.020633 0.008111 0.626105 0.003246 0.095579 0.001947 0 0.573119 0.002792 0.019273 0.024172 0.581655 0.000456 0.018962 0 0 0.834933 0.031271 0.015031 0.020966 0.482614 0.004527 0.023922 0.00245 3.96E-06 0.109658 0.007034 0.022912 0.008732 0.534617 0.000179 0.004968 1.26E-06 0 0 0 0.002164 0.003448 1.742931 0.000926 0.018063 0.001316 0 0.429415 0 0.010012 5.03E-06

Wiley-Blackwell and Society for Applied Microbiology Page 205 of 848

PhotorhabdusMethylobacterium asymbioticaVeillonella Fischer-Le extorquens parvulaMethanosarcina Saux strain strain etWautersia al. DSM 1999PA1-30 barkeri 2008-30 emend. eutrophaNitrosococcus strain Akhurst Fusaro-01 JMP134-01Legionella ethalophilus al. 2004-01 pneumophilaDickeya strain dadantii Nc4-30Psychrobacter subsp. strain pneumophila Ech703-30 sp. 273-4-08 strain Philadelphia 1-08 0.002502 0.002355 0 0.002355 0.009516 0.02781 0.018183 0 0.29671 2.06E-05 0.006657 0 0.000779 0.003442 0.021354 0 0.099749 0 0.000429 0.000635 0 1.79E-10 0.004302 0.047351 0.02115 0.006023 0.018974 0.00048 0.011507 2.24E-08 1.79E-05 0.00352 0.083842 0 0.064744 0.046889 0.00192 0.001723 0 0 0.000912 0.0319 0.006248 0.018315 0.016662 0 0.01306 0 2.65E-05 0.006063 0.098888 0 0.15739 0.054973 0.001712 0.005651 0 0.000123 0.008981 0.053399 0 0.014728 0.059904 0.002208 0 0 2.24E-14 0.006455 0.085493 0.016399 0.008229 0 0.001446 0.009825For Peer0 0 0.001226Review0.048528 Only0 0.026638 0.016228 0.001342 2.16E-16 0 2.74E-05 0.004986 0.016734 0.025993 0.034983 0.051804 0.001304 0 1.49E-09 4.29E-05 0.003927 0.03884 0.01753 0.102883 0 0.002521 3.22E-10 0 4.47E-05 0.001858 0.015108 0 0.033812 0.024184 0.002124 0.004585 0 0 0.008408 0.007707 0.034216 0.005556 0.086594 0.002074 0.002321 0 8.94E-05 0.001546 0.001695 0 0.004095 0.009105 0.000421 0.001763 0.002326 0.000214 0.009064 0.212458 0 0.015079 0.068454 0.000922 0.005027 4.84E-08 0 0.001854 0.05363 0.010351 0.013095 0.015973 0.002204 0.007989 0 8.77E-05 0.00728 0.078155 0 0.002912 0.035458 0.000721 0.000283 0 6.23E-05 0.000472 0.055137 0 0.006947 0.013145 0.002031 0.000314 5.96E-05 0 0.004076 0.05757 0 0.021774 0.097308

Wiley-Blackwell and Society for Applied Microbiology Page 206 of 848

MethanocorpusculumCoraliomargarita Aggregatibacterlabreanum akajimensis Acidovoraxstrain actinomycetemcomitans Z-08 strain Desulfovibriocitrulli DSM strain45221-08Prochlorococcus AAC00-1-30vulgaris strain vulgarisSynechococcus D11S-1-30 sp. (strain MIT9303-08alpha Hildenborough)-08sp. proteobacterium WH8102-01Ralstonia solanacearum IMCC1322-01 strain MolK2-30 0 0.354504 0 0.007187 0.011019 0.080079 7.75E-05 0.421786 0 0 4.23195 0 0.00484 3.75E-08 0 0.000818 0.155432 0 0 0.055363 0 3.42E-05 4.29E-06 0.079883 0.000988 0.244209 0.000139 0 0.308376 0.111604 0.000584 0.001455 3.10E-06 2.43E-08 0.478324 0.018508 0 0.046842 0 0.001815 0.001984 0.005399 0.000353 0.410982 0.00731 0 3.648743 1.47E-06 0.004685 0.006767 0.00054 0.001123 0.334892 0.000699 0 0.383673 0 0 0.000346 0.003492 3.88E-06 0.404615 0.000544 0 1.939146 0 0 0.00071 0 6.07E-05 0.348494 0.022804 0 0.062306For Peer0 0.003553 0.003663Review0.037305 0.000513 Only0.957427 1.78E-07 0 1.484601 0.098825 6.88E-05 0.000774 0.003124 0.000271 0.284417 0 0 2.243301 0 0.000198 0.000985 0.002458 0.00046 0.295771 0.000684 0 0.030205 0.007701 0.014277 0 0.023125 0.000525 0.736934 6.91E-05 0 0.56074 0.022657 0.00825 0.003198 0.006743 9.45E-05 0.56174 0.000567 0.001981 0.042141 0 0 0.002198 0.091365 0.016107 0.745938 0 0.004151 0.318579 0.058354 0.00807 0.004278 0.035517 4.40E-05 0.287837 0.003368 5.66E-05 0.217541 0.000582 0.004459 0.000297 0.080458 0.011489 0.770775 0.008022 0.000305 0.239047 0 0.000803 0.00394 0.028069 2.57E-06 0.318025 0.000929 0 0.277503 0.000114 0.010105 0 5.33E-12 0 0.201769 0.003741 0 0.352004 0.012523 0.008912 0.001073 0.003477 0 0.520976 0.00953

Wiley-Blackwell and Society for Applied Microbiology Page 207 of 848

Bacillus cereusBacteroides strain B4264-30Helicobacter fragilis strainPropionibacterium pylori NCTC strain 9343-08Microcystis HPAG1-30 acnesCandidatus aeruginosa strain KPA171202-08 Lactobacillus AzobacteroidesNIES-843-30Staphylococcus rhamnosus pseudotrichonymphaeRothia strain aureus mucilaginosa GG-08 subsp. genomovar. aureus strain USA300_FPR3757-01 DY-18-30 CFP2-01 0 0 0 0 0 0 0.013287 0 0 8.77E-11 0.002288 0 0 0.563213 0.004662 0 0 0 0 0.0139 0 0 0.027752 0.000321 0 0 0 0 0 0 0 0.079089 0 0 0 0 0 0 0 0 0.00788 0.007622 0 0 0 0 0.004754 0 0.007742 0.137088 0.008979 0 0 0 0 0 0 0.046843 0.023329 0.001448 0 0 0 0 0.007331 0 0 0.636515 0.003182 0 0 0.217827 0 0.006738For Peer0 5.15E-08 0.031571Review0.000579 Only0 0 0 0 0.007607 0 0.001835 0.167188 0.001564 0 0 0 0 0.00339 0 0.015389 0.554937 0.011759 0 0 0.097072 0 0 0 0 0.079436 0.007859 0 0 0 0 0.008102 0 0 0.263015 0.004745 0 0 0 0 0.00454 0 0 0.050218 0 0 0 0 0 0 0.035301 0 0.026609 0.001055 0 0 2.64E-05 0 0 0 0.005783 0.047567 0.001121 0 0.000236 0 0.000857 0.006198 0 0 0.004211 0.000765 0 0 0.000244 0 0 0 0.004151 0.094176 0.001947 0.00354 0 2.43E-05 0 0 0.051933 0 0.175007 0.006574 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 208 of 848

Geobacter bemidjiensisOchrobactrumFibrobacter strain anthropi Bem-08Marinobacter succinogenes strain ATCCPolynucleobacter 49188-30 hydrocarbonoclasticussubsp. succinogenesBrucella sp. canis QLW-P1DMWA-1-08Rhodopseudomonas S85-30 strain VT8-08 ATCCPropionibacterium 23365-30 palustrisStreptococcus strainacnes BisB18-01 strainpneumoniae SK137-01 strain ATCC 700669-30 0.034535 0.04666 0.000719 1.050433 0.016431 0 0.006299 0.036445 0 3.47E-06 0 0 0.801827 0.018642 0 0.000752 0.003725 0 0.003793 0.01739 0 0.210215 0.025688 0 0.001031 0.003654 0.024934 0.000777 0.003173 0 0.554664 0.019552 0 0.001566 0 0 0.000423 0.042413 0 0.223919 0.023285 0 0.002023 0.001445 0 0.005984 0.002885 0.110921 0.859927 0.052417 0 0.002297 0.001567 0 0.010164 0 0.019449 0.352605 0.022816 0 0.003156 0.003874 0 0.001135 0 0 0.827017 0.006949 0 0.000918 0.009148 0 0.001525 0.011332For0.002506 Peer0.188958 0.01453Review0 0.002857 Only 0 0 0.00434 0.006934 0 0.631876 0.031212 0 0.00134 0.002327 0 0.003355 0.003207 0 0.913797 0.018187 0 0.002203 0 0 3.64E-06 0.038401 0 0.764337 0.012639 0 0.002754 0 0 0.005259 0.045205 0 1.043757 0.039215 0 0.004117 0 0 0.002719 0.007297 0 0.0746 0.010645 0 0.004115 0.002947 0 0.020317 0.017935 0.004685 0.540458 0.053099 0 0.004313 0.000242 0 0.001791 0.011801 0.00943 0.271424 0.019868 0 0.002495 0 0 0.010489 0.029272 0.013415 0.409119 0.052045 0 0.001585 0.00429 0 0.000874 0.067334 0 0.349742 0.008604 0.071518 0.001102 0.001897 0 0.002174 3.13E-06 0 0.859442 0.043837 0 0.001278 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 209 of 848

NitratiruptorSulfolobus sp. SB155-2-08 solfataricusPicrophilus Granulobacter torridusstrain P2-01 strainuncultured bethesdensisDSM 9790-08 Yersiniamethanogenic CGDNIH1-08 pestisPseudobacterium bv.archaeon MicrotusSorangium Rice str. sepedonicum-01Cluster 91001-08 Mycobacteriumcellulosum I-08 strain bovis 'So ce BCG 56'-30 strain Pasteur 1173P2-30 0 5.47E-23 0.007579 0.191713 0.009754 1.25E-05 4.63E-06 0.089911 0 0.012351 0 0 0.021088 0.010959 0 3.60E-08 0.011038 0 0 0 0.001332 0.027144 0 0 0.000444 0.007351 0 0.001527 0 0 0.033324 0 0 7.17E-06 0.032441 0 0.011508 0 0 0.051852 0 0 6.66E-05 0.007191 0 0.001987 0 0 0.026067 0 0 3.18E-05 0.08631 0 0.000222 0 0.0002 0.093516 0.000188 0 1.28E-05 0.015299 0 0 0 0 0 0 0 2.77E-06 0.037847 0 0.002753 1.40E-12For Peer0 0.027894 0.001032Review0 Only0 0.014023 0 0.000182 0 0 0.025332 0.000253 0 0.000114 0.006633 0 0.005327 3.09E-08 0 0.025106 0 0 6.07E-05 0.087098 0 0 0 0 0.057702 0 0 8.12E-05 0.003169 0 0.00345 0 0 0.036158 0.000156 0.00453 3.87E-05 0.016571 0 0 0 0.018039 0.019783 0.013094 0 0.000579 0.005365 0 0 0 0 0.093516 0.008075 0 0.000162 0.025357 0 0.002958 0 0.006069 0.019917 0.002858 0 6.06E-09 0.00427 0 0.006223 9.28E-20 0.008139 0.129105 0.009766 0 0.000197 0.018831 0.000495 0.002532 0 0 0.017009 0 0 1.15E-06 0.022462 0 0.01252 3.72E-07 0 0.021701 0 0.001292 0 0.021166 0

Wiley-Blackwell and Society for Applied Microbiology Page 210 of 848

Escherichia Leuconostoccoli O26:H11Candidatus citreum strain 11368-30 strain ChlorobiumLiberibacter KM20-01Gordonia limicola asiaticus strainbronchialis strainSulfolobus DSM psy62-08 245-08strain islandicusKlebsiella DSM pneumoniaestrain43247-30Burkholderia L.S.2.15-01Mycobacterium strain cenocepacia NTUH-K2044-30 AU tuberculosis 1054-08 strain F11-08 0 0 0.036756 0.024805 2.03E-05 6.57E-23 0.007265 0.002924 0.005469 0 0 0 0.012918 0 0 0 0.003924 0 0.017354 0 0.003996 0.013124 0.004464 0 0.00155 0.001729 0 0 0 0 0.0002 0.000177 0 0.011571 0.002136 0 0 0 0 0.008376 0 0 0 0.001584 0 1.27E-05 1.21E-07 0 0.007262 0 0 0 0.003413 0 0.015805 0 0 0 0 0 0.008808 0.000914 0 0 0 0 0.001921 0 0 0 0.009594 0 0.000667 For0 0.000328 Peer0.004792 Review0 1.68E-12 0.005523 Only0.000939 0 0 0 0.002104 0.005111 0 0 0.002528 0.00385 0.00026 0 0.000129 5.14E-11 0.005303 0 9.95E-06 0.006449 0.003532 0 0 0 0 0.01559 0 0 0.025779 0.002212 0 0 0 0 0.007583 0 0 0 0.008394 0.009894 0 8.49E-05 0 0 0.000736 0 0 0.000908 0 0 0.000224 0 0.008266 0.002775 0 7.14E-06 0.005206 0 0 0 0.006525 0.001672 0 0 0.00287 0.002268 0.001087 0 3.71E-06 0.005239 0.012512 0.003747 0 9.80E-05 0.003445 0 0 0 0 0.000801 0 0 0.003528 0.001082 0 0.00377 0 0.004006 0.006386 0.006759 0 0 0.005427 0

Wiley-Blackwell and Society for Applied Microbiology Page 211 of 848

AzotobacterClavibacter vinelandii Rhodopirellulamichiganensisstrain DJ-30Escherichia subsp.baltica michiganensis strainLawsoniacoli strain SH 1-08intracellularis E24377A-08Methanocaldococcus strain NCPPBShewanella strain 382-30 PHE/MN1-00-01 vulcaniusCampylobacter sp. MR-7-08 strainSulfolobus M7-30concisus solfataricus strain 13826-08 strain P2-08 0.10046 2.01E-14 0.860397 0 0.005831 0 0 0 0 0.137737 0 0.010425 0 3.53E-12 0 0.033364 0 0 0.045711 0.002908 0.018339 0 4.31E-11 0 0.00687 0 0 0.260718 0 0.003445 0.000434 0 0 0.018687 0.00228 0 0.052189 0 0.008964 0 0 0 0.010731 1.66E-05 0 0.220743 0 0.010624 0 0.001695 0 0.022313 0 0 0.080236 0 0.088816 0 0.001504 0 0.010854 0.000152 0 0.150203 0 0.013052 0 0.000451 0 0.020819 0 0 0.084339 0.002492For0.021166 Peer0 0.000313Review0 0.012612 Only 0 0 0.100057 0 0.00481 0 0.005208 0 0.025063 0 0 0.265046 0.032414 0.008192 0 2.29E-05 0 0.023961 6.61E-05 0 0.101314 0 0.007368 0 7.80E-06 0 0.029523 0 0 0.100955 0 0.012917 0 0 0 0.040229 1.17E-10 0 0.003602 0 0.01005 0 0.001135 0 0 0 0 0.091206 4.04E-18 0.224622 0 0.004476 0 0.011835 0.013998 0 0.061288 0.005887 0.25382 0 0.001496 0.021353 0.009422 0 0.002817 0.043234 0 0.203481 0 0.000746 0.000443 0.010983 0 0.001326 0.129858 0.02162 0.000339 0 7.34E-05 9.72E-05 0.013577 4.48E-05 0 0.160508 0.024474 0.012087 0 0 0 0.021455 0.000853 0

Wiley-Blackwell and Society for Applied Microbiology Page 212 of 848

Geobacter lovleyialpha proteobacterium strainRhodobacter SZ-01 Clostridium IMCC1322-08 sphaeroidesRhodospirillum botulinum strain 2.4.1-01 FrancisellaA strain centenum ATCC tularensisPectobacterium 19397-30 strain SW-30subsp.Edwardsiella carotovora tularensisSyntrophus ictaluri strainsubsp. strain SCHU aciditrophicusatroseptica 93-146-01 S4-01 str. strain SCRI1043-08 SB-30 0.01297 0.822319 0.006543 0 0.000112 0 0.006093 0.001571 0.101693 4.85E-05 1.107761 0.003857 0 0.00353 0.00806 0.006979 0.000649 0 0.001609 3.263868 0.007968 0 0.028693 0.006317 0.002922 0.000938 0 0.00019 1.612449 0.06362 0 0.078865 0 0 0 0 0.001487 1.820564 0.028988 0 0.021985 0 0.008877 0.001497 0.013062 0.002509 1.618431 0.018249 0 2.93E-06 0.008528 0.016587 0.002886 0 0.005073 1.115522 0.021888 0 0.032819 0 0 0 0.034245 0.002829 1.431274 0.002807 0 0.113256 0 0.018905 0.003432 0 0.001086 1.798028For0.024345 Peer0 0.028116Review0 0.008936 Only0.00142 0.009249 0.001806 1.089385 0.000946 0 0.027722 0 0.012284 0.001502 0 0.002353 1.34877 0.0192 0 0.004087 0 0.009331 0.002171 0 0.001055 2.145538 0.005544 0 0.018537 0 0 0.002339 0 0.001273 1.759349 0.102291 6.93E-06 0.04011 0 0.017589 0.009684 0.002266 0.001456 1.231087 0.024304 0 0.010351 0 0.000384 0.00191 0 0.00449 1.259317 0.016843 0 0.110353 0.020323 0.010256 0 0.055204 5.34E-05 2.203662 0.019273 0 0.036579 0 0.003894 0.001407 0.028111 0.003811 1.103485 0.016213 0 0.075355 0 0.004976 0.002522 0.004788 0.001059 0.937508 0.021595 0 0.001697 0 0.005652 0.000471 0 7.47E-05 1.752489 0.070214 0 0.033012 0 0.018984 0.003981 0

Wiley-Blackwell and Society for Applied Microbiology Page 213 of 848

Chlamydia trachomatisRhodopseudomonasStenotrophomonas strain B/TZ1A828/OT-01 palustrisMycobacterium strain maltophiliaMesorhizobium TIE-1-01 tuberculosis strainFlavobacterium R551-3-01 loti CSU#93-08 strainYersinia MAFF303099-30 psychrophilum pestisSulfolobus strain strain Angola-01 islandicusOrientia JIP02/86-08 tsutsugamushi strain M.16.27-01 strain Boryong-01 0 0.006494 0.004893 0 0.083072 0.164461 0.001082 6.78E-23 0 0 9.89E-05 0.000307 0 0 2.479897 3.74E-08 0 0.000938 0 0.001206 0.002869 0 0.052726 1.290466 0 0 1.30E-05 0 0.001017 0.001754 0 0.207397 1.245274 0.000889 0 0.00138 0 0.001995 0.001987 0 0.050302 1.260266 0 0 0.002384 0 0.001313 0.002153 0.000131 0.162542 2.158658 0 0 0.000706 0.000468 0.002018 0.003149 0 0.059788 0.681664 0 0 0 0 0.001493 0.001947 2.15E-05 4.66E-07 3.188312 0.000847 0 3.84E-08 0 0.002711For0.001596 Peer0 0.017075Review0.695005 0.000153 Only 0 7.56E-05 0 0.000972 0.001124 0.000262 0.04273 2.788711 0.000807 0 0.001457 0 0.002546 0.001354 0 0.060543 1.750063 0 0 0.001788 0 0.002947 0.001005 0 0.021516 1.401576 0 0 0.001578 0 0.002488 0.004476 0 0.071583 2.213485 0.002829 0 0.001275 0 0.003002 0.00114 7.61E-05 0.018916 0.201163 0 0 0.000353 0 0.004962 0.002526 0 0.038085 0.786602 0 0 5.97E-05 0 0.003435 0.000757 0.001097 0.013836 0.196772 0 0 0.00079 0 0.001992 0.006107 0 0.07425 0.472204 0.001487 0 0.001037 0 0.000987 0.001042 0 0.046887 1.317448 0 0 0.000248 0 0.002487 0.002928 0 0.047387 1.774716 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 214 of 848

Candidatus OrientiaVesicomyosocius tsutsugamushiFlavobacterium okutaniiMethanothermobacter strain strain johnsoniae Ikeda-08 HA-01Gemmatimonas strain StaphylothermusUW101-30 thermautotrophicus aurantiacaMycobacterium strain marinus str. VibrioT-27-01 deltaH-08 strain sp. fischeri JLS-08 F1-08Picrophilus strain MJ11-08 torridus strain DSM 9790-30 1.858798 0 0.326604 0.000233 0.106434 0 0.002028 0.010978 0 0.953117 0 0.879333 0 3.77E-06 0 0.001231 0.005887 0 1.413419 2.85E-05 1.039932 6.92E-07 0.000627 0 0.00103 0.016538 0 1.010431 0 0.652839 0 0.001324 0 0.001024 0.007718 0 0.091545 6.78E-06 0.663461 0 0.000808 0 4.98E-05 0.033314 0 2.949325 0 0.498829 0 0.001509 0 0.003298 0.123191 0 2.634447 0 0.289912 0 0.008887 0 0.001132 0 0 3.558861 0 0.930573 0 0.004747 0 0.001433 0.0525 0 0.594808 For0 0.476493 Peer0 0.000456Review0 0.000985 Only 0 0 2.211593 0 1.286032 0 0.000431 0 0.000145 0.036115 0 2.017095 0.004903 0.942859 0 0.00065 0 0 0.007798 0 0.145371 0 0.66713 0 0.000593 0 0 0 0 2.072291 0 1.478319 0 0.001237 0 0.001062 0.026425 0 0.362577 0 0.314632 0.003174 0.001335 0 0.001149 0.007354 0 3.231051 0.007249 0.37783 0.007287 0.009342 2.47E-11 0.003934 0.035301 0.002215 0.172494 0.009675 0.522944 0.001838 0.000257 0.003599 0.000774 0.013161 0.014871 2.348684 0 0.285597 5.55E-06 0.009861 0.00309 0.001883 0.015448 0 0.156611 3.10E-11 0.526134 0 3.73E-05 0 0.000384 0.021789 0 2.134858 7.44E-10 1.092794 0 0.000634 0 0.001689 0.065215 0

Wiley-Blackwell and Society for Applied Microbiology Page 215 of 848

AnaerocellumMethanothermobacter thermophilumMethylobacterium strainEscherichia thermautotrophicus DSM 6725-30 sp. Shewanella4-46-01coli strain str.ED1a-30Ochrobactrum baltica deltaH-30 strainBurkholderia OS185-30 anthropiLeptothrix strain vietnamiensis ATCC cholodniiPseudomonas 49188-08 strain strain G4-30 putida SP-6-08 strain F1-08 0 0.000431 0.008821 0 0.005693 0.057787 0.000184 0.014875 0.022633 0 0 0.001032 0 0 0.0527 0.003098 0.013438 0.088316 0 0 0.001128 0.002431 0.003658 0.061394 3.29E-05 0.007323 0.025887 0 0 0.004667 0 0 0.110119 0.028181 0.023363 0.047418 0 0 0.001921 0.002102 0.022429 0.073137 0.00236 0.012883 0.017354 0 0 0.001918 0 0 0.052484 0.092118 0.02521 0.083369 0 0 0.004756 0 0.012809 0.040512 0.014238 0.014098 0.027893 0 0 0.001491 0 0 0.035111 0.122108 0.054977 0.096944 0 For0 0.00349 Peer0 0.037647Review0.030136 0.004788 Only0.004142 0.018405 0 0 0.002202 0 0 0.025033 0.029214 0.025729 0.063651 0 0 0.003046 0 0 0.03674 0.026199 0.026081 0.086054 0 0 0.003176 0 0.06351 0.095288 0.009755 0.012575 0.066634 0.017129 0 0.002698 0 0 0.075553 0.003456 0.028855 0.122325 0 0.000499 0.001699 0 0 0.008669 1.79E-05 0.001438 0.004267 0 0 0.003406 0 0.018652 0.091545 0.014936 0.015728 0.034663 0 0 0.002431 0.005441 0.017501 0.017465 1.84E-10 0.002799 0.020603 0 0.009768 0.003272 0.001378 0.011169 0.050883 0.009051 0.01997 0.016508 0 0 0.001166 0.01367 0.0418 0.057949 0.017526 0.009632 0.025478 0 0 0.003319 0 0.017257 0.079147 0.012028 0.030125 0.10305

Wiley-Blackwell and Society for Applied Microbiology Page 216 of 848

deep-sea eubacteriumEscherichia DictyoglomusSS9-01coli strain K12Micrococcus thermophilum substrainBacteroides luteus DH10B-01 H-6-12-08 strainSalmonella fragilis NCTC strain 2665-30 Lactobacillusparatyphi YCH46-30 CBurkholderia strain rhamnosus RKS4594-08Lactobacillus sp.strain 383-01 GG-01 rhamnosus strain GG-30 0.01332 0 0.005491 0 0.00849 1.49E-06 0 0.00175 0 0.002787 0 0 0 0 0.001984 0 0.000624 0 0.004329 0 0 0 0.026399 0 0 0.000755 0 0.005835 0 0 0 0.016223 0 0 0.001917 0 0.002814 0 0 0 0 0 0 0.000687 0.005921 0.009098 0 0 0 0.07061 0 0 0.001469 0 0.011883 0 0 0.036976 0.018869 0 0 0.002682 0 0.012084 0 0 0 0 0 4.06E-05 0.002364 0 0.006716 For0 0.000226 Peer0 Review0 0 Only0 0.000419 0 0.005909 0 0 0.04923 5.11E-05 0 0 0.001119 0 0.007151 0 0 0 0.115717 0.010319 3.16E-06 0.001072 0 0.002932 0 0 0 0.006985 0.005334 0 0.001044 0 0.018341 0 0 0.002579 0.038666 0.009623 0 0.002585 0 0.003584 0 0 0 0.0145 0.001389 0 0.001164 5.18E-05 0.01147 0 0.012067 0 0.024541 0 0 0.000399 0 0.00263 0 0.000364 9.15E-30 0.015291 0 0 0.000118 0 0.013601 0 0.003493 0.027676 0.014554 0 0 0.000996 6.06E-08 0.001705 1.28E-09 0 0 0 0 0 0.000195 0 0.011667 0 0 8.89E-09 0.011719 0 0 0.00332 0

Wiley-Blackwell and Society for Applied Microbiology Page 217 of 848

Chlamydia trachomatisStreptococcusStreptococcus strain pyogenes B/Jali20/OT-01Edwardsiella MGAS8232-30 pneumoniaeRickettsia tarda str. strain R6-30 peacockiiEscherichia EIB202-08 strain Onionfergusonii Rustic-30 yellows strainSaccharomonospora phytoplasma ATCC Burkholderia35469-08 str. 'onionviridis cenocepacia strainyellows'-08 DSM AU 43017-08 1054-01 0.003857 0 0.424918 0.015233 0.170397 0.002263 0.004539 0.029641 0.000415 0 0 0 0.032096 0 0 0 0 0.00112 0 0 0 0.013201 0 0.00631 0 0.002211 0.000287 0 0 0 0.014812 0 0.006104 0 0.002569 0.000332 0 0 0 0.002473 0 0.006973 0 0.000766 0.000613 0 0 0 0.024428 0 0 0 0.0046 0 0 0 0 0.008145 0 0 0 0.009294 0.000751 0 0 0 0.02985 0 0 0 0.003831 0.000606 0 For0 Peer0 0.009159 Review0 0.003352 Only0 0.000805 0.000187 0 0 0 0.017603 0 0.008278 0 2.93E-05 0.000113 0.000882 1.42E-06 0 0.022777 0 0 0 0.002863 0.000424 0 0 0 0.035845 0 0.009179 0 0.000953 0 0 0 0 0.044226 0 0.009284 0 0.006319 0.001515 0 0 0 0.003425 0 0 0 0.006386 5.31E-05 0 0 0 0.011734 0 0 0 0.011315 0.001505 0 0 0 0.004494 0 0.001791 0 8.56E-05 0 0 0 0 0.014708 0 0 0 0.003951 0 0 0 0 0.008215 0 0 0 0.000108 0.000212 0 0 0 0.028472 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 218 of 848

ShewanellaBacillus halifaxensis weihenstephanensisBrucella strain HAW-EB4-30 abortusStaphylococcus strain strainBacteroides S19-08 KBAB4-08 epidermidisKribbella fragilis ATCC strain flavida Pseudomonas12228-01 YCH46-08 strain MethylobacteriumDSM aeruginosa 17836-08Coprothermobacter strain sp. LESB58-08 BJ001-01 proteolyticus DSM 5265-08 0.074415 0.00085 0 0 0.012601 0.011313 0.029057 0.00697 0.019048 0.115797 0.000175 0 0 0 9.48E-05 0.09542 0.000821 0 0.002502 0 0 0 0.013302 0.003622 0.030684 0.002784 0 0.083706 0 0 0 0.023358 0.000379 0.061931 0.003586 0 0.028081 0 0 0 0.008269 0.002347 0.02049 0.002357 0 0.086061 0.000825 0.024346 0 0.008638 0.000309 0.100997 0.002356 0 0.030322 8.69E-07 0 0.000115 0.015324 0.00091 0.035851 0.002442 0 0 0 0.011586 0 0.010839 8.55E-05 0.09257 0.002112 0 0.060061 0.000128For0.014086 Peer0 Review0 0.000355 0.029559 Only0.002298 0 0.004952 1.38E-06 0 0.001318 0.007192 0.000894 0.085423 0.00099 0 0.108218 0 0 1.76E-05 0.008094 8.26E-05 0.12046 0.002224 0.006913 0.106785 0 0.052286 0 0.019546 0.013254 0.071617 0.002248 0 0.019278 0.00048 0 0 0.008254 0.000115 0.151365 0.003866 0 0.032443 0 0 6.98E-08 0 6.73E-05 0.007294 0.003987 0 0.066758 0.000808 0 0.00036 0.01991 0.010506 0.049966 0.003057 0 0.062497 0 0 0 0.002215 0.001431 0.027358 0.00196 0 0.025695 0.000282 0 0.000201 0.006037 0.001893 0.03177 0.003148 0.004023 0.085471 1.22E-06 0 0 0.002248 0 0.032518 0.000603 0 0.045526 6.69E-05 0 8.50E-11 0.013595 0.000555 0.126571 0.002188 0

Wiley-Blackwell and Society for Applied Microbiology Page 219 of 848

Hahella chejuensisPaenibacillus strainAnoxybacillus sp.KCTC JDR-2-08 2396-30Micrococcus flavithermusBlattabacterium luteus strain strain PedobacterWK1-08 NCTC sp. Alboraia-012665-01Pseudomonas heparinus strainAzotobacter putida DSM strain Sphingobium2366-08 vinelandii F1-01 strain japonicum DJ-08 strain UT26S-01 0.098286 0.019191 0.017899 0.000354 0.017517 0.053423 0.005749 0.037605 0.029857 0.124415 0.000985 9.86E-11 0 0.010062 0.111444 0.002322 0.1814 0.00127 0.042178 0.003382 0.001379 0 0.001004 0.194429 0.003391 0.044166 0.002096 0.451241 0.000294 1.66E-06 0 0.018779 0.112002 0.009188 0.10368 0.004597 0.202642 0.005645 0.000117 5.45E-05 0.01607 0.114066 0 0.04402 0.002574 0.269257 0.004465 0 0.000133 0.028718 0.08206 0.011583 0.180406 0.0023 0.153311 0.006245 0 6.67E-09 0.027061 0.105356 0.006223 0.060644 0.005904 0.35401 0.008256 0 3.79E-06 0.048275 0.180054 0.008023 0.189593 0.003621 0.204606 0.001896For3.61E-10 Peer0 0.008226Review0.05779 0.004051 Only0.02796 0.005858 0.301093 0.002939 0 0 0.008717 0.118296 0.006926 0.127753 0.003227 0.189431 0.005798 0.000815 0.001604 0.025005 0.070462 0.007007 0.180745 0.005417 0.375883 2.99E-05 3.42E-12 0.000699 0.020308 0.101688 0.007298 0.14017 0.003889 0.287535 0.007153 0.009605 0.001685 0.031937 0.106941 0.02685 0.232872 0.001114 0.04615 0.002299 0 0.000203 0.041117 0.034544 0.001909 0.015992 0.00672 0.252225 0.00067 0.015382 0 0.01026 0.19092 0.00794 0.073582 0.004145 0.236926 0.004984 0.005668 6.61E-05 0.00627 0.038329 0.002061 0.036688 0.002933 0.076486 0.004102 0.001577 0 0.026378 0.101294 0.007119 0.066737 0.004454 0.186143 0.001596 0 0.000856 0.003098 0.047073 0.001661 0.066392 0.001394 0.242569 0.009118 0.000513 0.000263 0.021822 0.098979 0.017204 0.183207 0.001586

Wiley-Blackwell and Society for Applied Microbiology Page 220 of 848

Escherichia Salinibactercoli strain CFT073-30Brevibacillus ruber strainRhodopseudomonas brevisDSM 13855-30 strainDeferribacter NBRC 100599-30palustrisMycobacterium desulfuricans strainRhodobacter TIE-1-08 bovisstrain subsp. LeptospiraSSM1-30 sphaeroides bovis borgpeterseniiStreptococcus str. strain AF2122/97-30 2.4.1-08 pyogenesserovar Hardjo-bovis strain NZ131-08 strain JB197-30 0 0 0 0.01735 0.038054 0 0.044705 0 0 0 0 0.065011 0.004888 0 0 0.11935 0 0 0 0.01064 0.023333 0.01223 0 0 0.337997 0 0 0.018877 0 0.000116 0.006619 0 0 0.415232 0 0 0 0.006527 0.000506 0.007403 3.89E-05 0 0.315006 0 0 0 0.046113 0 0.003585 0 0 0.203664 0.008239 0 0 0.002429 3.20E-05 0.013558 0 0 0.138764 0.004815 0 0 0 0 0.004537 0 0 0.148726 0 0 0.022044 0.000923For2.58E-20 Peer0 1.55E-13Review0 0.124919 Only 0 0 0.000662 0 0 0.003375 0 0 0.132304 0 0 0 0 0.034913 0.004426 0 0 0.125022 0 0 0 0 0 0.001821 0 0 0.28578 0 0 0 0 0.00105 0.013493 0 0 0.253823 0 0 0 0 0.010438 0.006111 0.043647 0.000163 0.054614 0 0 0.001095 0.027613 0.000607 0.012585 0.052722 0.004112 0.128227 0 0 0 0.002383 0.001161 0.005702 0 0 0.10173 0.001778 0 0 0.013972 0.010449 0.016006 0.041474 0 0.114104 0.018235 0.001254 0.019032 0 0 0.009212 0.057829 0 0.270769 0 0 0 0 0.001799 0.006449 0 0 0.311213 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 221 of 848

RhodospirillumChlamydia rubrum trachomatisEubacterium strain ATCCPelagibacter strain rectale11170-30 B/TZ1A828/OT-08 strainClostridium ubique ATCC HTCC1062-08 33656-01Thermotoga novyi-NT-01Vibrio sp. RKU-10-08 salmonicidaVibrio cholerae LFI1238-30Zymomonas strain MJ-1236-08 mobilis subsp. mobilis strain NCIMB 11163-30 0.007479 0 0.000268 22.30823 0.004586 0 0.006714 0.082899 0 0.042696 0 0 12.1436 6.08E-09 0 0 0 0.184094 0.05918 0 1.65E-07 27.79823 4.69E-05 0 0 0.013347 0 0.006979 0 0.000205 29.06444 9.47E-12 0 0.088281 0 0 0.018669 0.012023 0 33.33017 1.10E-07 0 0.053404 0 0.072605 0 3.39E-12 0 11.75393 8.04E-06 0 0.179889 0 0 0.025163 0 0.000366 35.2156 0.001129 0 0.017528 0.035676 0 0 0 0.000374 10.99568 0.001419 0 0.028939 0 8.77E-06 0.038047 For0 Peer0 43.70105 0.000395Review0.001545 0.022435 Only0.034201 0.054857 0.087318 0 0.000169 25.88823 1.82E-05 0 0 0 0 1.18E-05 0 8.10E-05 25.06504 0.000169 0 0.08117 0.066349 0.039949 4.06E-09 0 3.69E-19 18.80212 3.19E-10 0 0.095721 0.11702 0.081596 0.005245 0 0.000107 10.26282 0 0 0.002599 0.092089 0 0.004823 0 0.001587 9.620661 5.42E-05 0 0.017988 0 0 0.047231 0 0.002576 19.0656 0.00016 0 0 0.028103 0.060338 0.028785 0 0 16.7474 4.24E-09 0 0.024699 0.040434 0 0.045308 0 3.48E-05 32.31915 4.55E-06 0 0.011777 0.037031 0.025146 4.48E-05 0 0 45.73783 3.72E-06 0 0.004902 0.045804 0.024902 0.037942 0 2.20E-05 17.89314 0.001211 0 0.083911 0.07082 0

Wiley-Blackwell and Society for Applied Microbiology Page 222 of 848

PorphyromonasGeobacillus gingivalisPseudoalteromonas sp. strainWCH70-08 ATCCPseudomonas 33277-30 atlanticaAlicyclobacillus putida strain GB-1-30Rhodopseudomonas T6c-08 acidocaldariusPirellula subsp. staleyi palustrisGeobacter acidocaldarius strain strain DSMsp.Chlorobium HaA2-08M21-08 6068-01 strain chlorochromatii DSM 446-01 strain CaD3-30 0 0.014732 0.323516 0.030983 0.008516 0.046148 0.087669 0.025543 0 0 0.006998 1.013659 0.17627 0 0.008011 2.25E-05 3.28E-06 0 0 0.004046 0.073338 0.011211 0.000311 0.010484 0.000854 0.004039 0.001071 0 0 0.265663 0.067912 0 0.006901 0.001348 0.007582 0.045218 0 0 0.282609 0.066586 0 0.008075 0.000577 0.000619 0 0 0 0.536498 0.030318 0.000995 0.006717 0.001067 0.007847 0 0 0.002929 0.208772 0.034854 0.001016 0.019698 0.004633 0.010979 0 0 0.004287 0.509776 0.253109 7.32E-05 0.009515 0.000814 0.01457 0 0.019782 For0 0.263571 Peer0.044658 0.000288Review0.009863 0.002693 Only0.00129 0 0.069778 0 0.240169 0.058655 9.13E-15 0.004362 0.00033 0.005956 0 0.038379 0.000161 0.335143 0.219483 0.001056 0.005503 0.000869 0.001023 0 0 0 1.663957 0.039363 0.000254 0.005523 0.000134 0.000104 0.004683 0 0.000328 0.369669 0.07222 0 0.013351 0.00053 0.007485 0 1.39E-05 0 0.119553 0.021592 5.02E-05 0.011432 0.00229 0.0049 0.02166 0.060368 0.014298 0.154117 0.04329 0.00233 0.013738 0.003149 0.008728 0.016605 0.027555 6.22E-05 0.460055 0.038501 0.000162 0.006514 0.020045 0.001086 4.07E-08 0.05222 0.00164 0.16531 0.014451 0.000556 0.020942 0.003149 0.007484 0.018431 0 3.39E-16 0.29807 0.033198 9.09E-09 0.005367 4.05E-06 0.004386 0 0 0 0.311979 0.036829 2.54E-06 0.011973 0.000712 0.004699 0.009858

Wiley-Blackwell and Society for Applied Microbiology Page 223 of 848

StreptococcusSalmonella agalactiae Pseudoalteromonasenterica str. NEM316-01 subsp.Borrelia enterica recurrentis haloplanktisListeria serovar monocytogenes strain Paratypi strainDehalococcoides A1-30 TAC125-08 A str.Mycobacterium strain ATCC ethenogenes HCC23-019150-01Borrelia sp. strainburgdorferiKMS-01Haemophilus 195-30 strain influenzae ZS7-01 Rd KW20-30 0 0 2.816937 0 0.000487 0 8.89E-05 0 0 0 0 0.217421 0 8.80E-06 0 3.52E-06 0 0 0 0 0.046524 0 8.65E-06 0 0.000278 0 0.164339 0 0 0.596492 0 0 0 0 0 0 0 0 0.123992 0 0 0 0 0 0.129436 0 0 0.395546 0 0.000102 0 0.000158 0 0 0 0 0.23398 0 1.42E-05 0 0.000257 0 0.382432 0 0 0.235539 0 0 0 0.000234 6.62E-16 1.442952 0 For0 0.169464 Peer0 Review0 0 Only0 0 0.147957 0 2.15E-06 0.200182 0 0.000379 0 0 0.000849 0 0.000553 0 0.412011 0 3.44E-05 0 0.000165 0 1.016851 0 0 0.625147 0 0.000942 0 0 0 0.101297 0 0 0.400064 0 0 0 0 0 0.45706 0 0 0.377439 0 0 0 0 0 0.18552 0 0 0.338915 0 0.001556 0.011853 6.48E-06 0 0 0 0 0.16063 0 1.18E-05 0 0 0 0.300451 0 0.000147 0.453996 0.000209 0.00027 0.040796 6.24E-05 0 0 0 0 0.624072 0 0 0 0 0 0.10229 0 0 0.245667 0 0.000205 0 0.000265 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 224 of 848

StreptococcusNostoc equi sp. subsp. PCCChromobacterium zooepidemicus7937-01Lactobacillus violaceum strainSynechococcus plantarum MGCS10565-30 str. ATCCMethanococcoides strain sp. 12472-01 PCC7002-30JDM1-08Chlorobium burtoniiAeropyrum phaeobacteroides str. DSMHaemophilus pernix 6242-01 strain strain ducreyiK1-01 BS1-08 str. 35000HP-08 0 0.003366 0.003548 0 0 0.014866 0.013673 9.17E-14 0.016037 0 0.00247 0.000319 0 1.722806 0.001475 0.000462 0 0 0 0.001265 0.002122 0 0 0 0.021287 0 0.007307 0 6.90E-05 0.000427 0 0.039083 0 0 0 0.021463 0.045274 0.000195 0.002002 0.001356 0.046484 3.86E-09 0.017158 0 0 0 0.001822 0.007257 0 0.165076 0 0.009895 0 0 0 0.00145 0.003934 0 0.11563 0.000869 0.009503 6.78E-13 0.015653 0 0.000702 0.004721 0.000327 0.470581 2.45E-06 0.014636 0 0 0 2.72E-05For0.004649 Peer0 0.090024Review0.000332 0.018703 Only 0 0.011537 0 0.000444 0.002703 0 0.575217 0 0.011952 0.000293 0 0 0.000584 0.004175 0 0.190035 0.0002 0.008269 1.46E-06 0 0 0.000627 0.00381 0 0.143547 0.001886 0.000172 0 0.000101 0.009564 2.86E-05 0.008472 0 0.350003 2.82E-09 0.024537 0 0.054357 0 0.001117 0.003444 0 0 3.40E-06 0.012443 0 0 0 0.000456 0.004202 0 0.060406 0.00485 0.019349 6.43E-07 0 0 0.000123 0.001152 0.001257 0.094467 0 0.008228 0 0.013926 0 0.000403 0.006074 0.000277 0.046136 0.003161 0.010722 6.09E-05 0.011226 0 1.38E-06 0.001493 0 0.29814 0 0.004208 0 0 0 0.000258 0.009395 0.002652 0.26721 0 0.005851 0 0.038575

Wiley-Blackwell and Society for Applied Microbiology Page 225 of 848

Escherichia Robiginitaleacoli strain SE11-08Bordetella biformata pertussisChlorobium strain HTCC2501-01 TohamaLeptospira chlorochromatii I-08 biflexaBacillus strain serovar cereusPseudomonas CaD3-08 Patocstrain strainAH187-08Streptomyces sp. Patoc1-30 AM1-01Methanocaldococcus coelicolor A3(2)-08 fervens strain AG86-08 0 0.176912 0.009816 0.032702 0 0.000561 0.002787 0.005968 0 0 0.19817 0.009753 0.007179 0 0 0.000272 1.88E-05 0 0 0.239336 0.004534 0.002541 0.008154 0.00069 0.000899 0.001659 0 0 0.391074 0.004144 0.00972 0 0 0.000552 8.64E-06 0 0 0.303219 0.004878 0.002163 0 0 0.001122 0.001146 0 0 0.552329 0.002433 0.011299 0 0 0.000702 0.001247 0 0 0.217698 0.005644 0.038492 0.00232 4.07E-06 0.001735 0.001179 0 0 0.730785 0.004819 0.016034 0 0.002727 0.001046 0.000283 0 0 0.206439For0.003498 Peer0.014758 0.002998Review0 0.001052 Only1.31E-05 0 0 0.399037 0.004959 0.006058 0.007213 0 0.000349 0.001914 0 0 0.461661 0.005678 0.009756 0 0 0.000743 0.000644 0 0 0.445813 0.001871 0.007751 0.054459 0 0.000997 2.57E-07 0 0.002086 0.797114 0.010444 0.011287 0.000748 0 0.000834 0.001822 0.003107 0 0.315991 0.000519 0 0 0 0.001668 9.85E-14 0 0 0.221261 0.005715 0.028828 0.046272 0 0.001776 0.00323 0 0 0.139801 0.001945 0.000943 0 0 0.00118 0.00023 0.000917 3.42E-05 0.281335 0.00752 0.023752 0.019943 0 0.001356 0.005264 0.003348 0 0.158924 0.003183 0.000503 0.020195 0 0.000417 0 0 0.003224 0.81525 0.007734 0.009037 0.007754 0 0.00078 0.001486 0.008199

Wiley-Blackwell and Society for Applied Microbiology Page 226 of 848

StreptobacillusClostridium moniliformisXanthomonas botulinum strain NocardioidesBa4 DSM euvesicatoria strain 12112-08 657-30Chloroherpeton sp. str.JS614-30 85-10-30Thermoanaerobacter thalassiumParamecium strain sp. ProsthecochlorisATCC bursaria X514-08 35110-08 ChlorellaDiaphorobacter aestuarii virus PBCV-1-01 strain sp. TPSY-30 DSM 271-01 0.000503 0 0.000109 0.094273 0.08296 0.023979 0 0.015737 0.148835 0 0 0 0 0.005007 0 0 0.001561 2.38E-06 0 0 0.001006 0.014115 0.008843 0 0 0.002149 0.001463 0 0 0.010911 9.22E-05 0.014487 0 0 0.000991 0.027867 0 0 0.012407 0 0.007508 0 0 0.001472 0.017595 0 0 0.002197 0 0.011424 0 0.00881 0.001767 0.079028 0 0 0.006759 0 0.032929 0.003429 0 0.00516 0.005848 0 0 1.83E-28 2.67E-26 0.019168 0 0 0.00811 5.73E-06 0.000254 For0 0.012816 Peer0 0.005591Review0 Only0 0.001206 0.001804 0 0.0057 9.25E-07 0 0.018152 0 0 0.002406 0.001687 0 0 0 0 0.007807 0 0.017129 0.002926 0 0 0 0.009613 0.014782 0.013356 0 0 0.001245 0.058648 0 0 0.004685 0 0.012033 0.004645 0 0.002964 0.006077 0 0.000142 0.001101 0 0.006096 0 0 0.003749 0.00243 0 1.63E-14 0.021434 0.085325 0.039738 0.000207 0 0.011276 0.035024 0.004081 0 0.004591 0.006138 0.005577 0.001723 0 0 0.001288 0 0.000472 0.007972 0.044113 0.027375 0 0 0.007547 0.005302 0 0 0.001464 0 0.002202 0 0 0.000594 0.011941 0 8.03E-11 0.003214 0.006699 0.007294 0 0 0.011766 0.005221

Wiley-Blackwell and Society for Applied Microbiology Page 227 of 848

Bartonella tribocorumEscherichia Clostridiumstraincoli strain CIP 105476-08SMS-3-5-08Pectobacterium botulinum BurkholderiaA2 strain carotovorum Kyoto-08Acidobacterium pseudomallei subsp.Salmonella carotovorum straincapsulatum 1106a-08Pyrococcusenterica strain strain subsp. NeisseriaPC1-08abyssi ATCC enterica 51196-30strain meningitidis GE5-01serovar Heidelberg strain FAM18-01 str. SL476-08 0.017718 0.008053 0 0 0.00089 0.003668 0 0.009969 0 0.001842 0.001046 0 0.010392 0.003071 0 0 0 0.001013 0.004736 0 0 0.002688 0.001923 0.00819 0 0 0 0 5.75E-06 0.000838 0 0.001335 0 0.005867 0 0 0.009404 0 0 0.008333 0.001274 0 0.004837 0 0 0.000967 0 0.003391 0 0.002827 0 0 0 0 0.007413 0 0 0 0.001336 0.022521 0 5.27E-18 0 0 0 0 0.036379 0.00266 0 0.008391 0 0.004847 0 For0 0.000603 Peer0.003683 0.000891Review0.009184 Only0 0 0 0.004373 0.00123 0 0.015413 0.002637 0.004833 0.002743 1.49E-05 0.001945 0.007064 0 0 0.020674 0.002179 0 0 7.53E-05 0.004032 0 0 0 0 0.015907 0.00501 0 0 0 0 0 2.07E-05 0.024618 0.003384 0 0.011794 0 0.010254 0.003621 0 0 0.00125 0 1.94E-07 0.001336 5.51E-05 0 0.006066 0 0.000101 0 0.002317 0.021087 0.012096 5.64E-07 0 0 0 0 0.00416 0.001086 3.80E-11 0.001337 0 0 0.009508 0.000621 0 0.006915 0.003212 0.016329 0 4.34E-05 0 0 0.000214 0 0.006136 0.001135 0 0.005522 0 0.00054 0 0 0.000663 0.016848 0.003131 0.001914 0.013821 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 228 of 848

StreptococcusHalorubrum pneumoniaeCampylobacter lacusprofundi strain Beijerinckia70585-30 strainconcisus ATCCClostridium indica strain 49239-01 subsp. 13826-30Blattabacterium beijerinckii indica strainSynechococcus strain ATCC sp. NCIMB (Periplaneta 9039-30Sorangium 8052-08 sp. PCC americana) Carboxydothermuscellulosum 7424-08 strainstrain BPLAN-01'So hydrogenoformans ce 56'-08 str. Z-2901-08 0 5.44E-06 0 4.32E-05 0.001383 8.07E-05 0.014657 0.046385 0 0 0 0 0.004926 0 0.008348 0.010077 0.010611 0 0.050592 0.000615 0 0.044941 0.001247 0.003752 0.004959 0.001975 0 0 0 0 0.023535 0 0.030337 0.000962 0.002526 0 0 0 0 0.025071 3.29E-06 0.029522 0.003008 0.000964 0 0 0 0 0 3.10E-13 0.032072 0.008216 0.003041 0.008035 0 0 0 0.00375 1.76E-07 0 0.009587 0.010515 0.018024 0 3.70E-05 0 0 0 0 0.007477 0.005176 0.007404 0 For0 Peer0 0.024864 Review0 0.01093 0.006047 Only0.002232 0.00268 0 0 0.001101 0.028115 7.46E-05 0.015487 0.00455 0.00153 0.003908 0 1.37E-06 0 0.055778 1.30E-09 0.037877 0.000795 0.001515 0.008202 0 0 0 0.01982 0 0.00958 0.011616 0 0 0 0 0 8.37E-15 1.72E-05 0.021809 0.000534 0.002905 0 0 0 0 0.012559 0 0 0.005019 0.002808 0 0 3.45E-06 0.011899 0.003853 0 0.019816 0.005152 0.004904 0.024255 0 0 0 1.76E-05 0 0.007149 0.005497 0.004069 0.000842 0 0 0.000165 0.015602 0.000309 0 0.007144 0.004902 0.017293 0 0 0 0.032338 0 0.012065 0.001058 1.96E-05 0 0 0 0 8.34E-05 0.000355 0.046476 0.006184 0.000194 0

Wiley-Blackwell and Society for Applied Microbiology Page 229 of 848

ClostridiumAnaplasma botulinum BeutenbergiamarginaleBa4 strain subsp.657-08Micrococcus cavernae centraleShewanella strain luteus str. DSM Israel-30ATCCClostridium denitrificans 12333-30 9341-01 Microscilla perfringens strain OS217-01 Natranaerobiussp. strain PRE1-01 SM101-30Clostridium thermophilus phytofermentans strain JW/NM-WN-LF-08 strain ISDg-08 0 0 0 0.000546 0.001609 0 0 0.019842 0.014056 0 0 0 3.27E-08 0.001156 0 0 0 0.007189 0 0.024836 0 1.91E-05 0.002262 0 0.022342 5.49E-08 0 0 0 0 0 0.005621 0 0 0 0 0 0 0.002161 0.000853 0.002227 0.008055 0 0.001122 0 0 0 0 0.00049 0.007183 0 0.029159 0.00032 0 0 0 0 0 0.004534 0 0 0 0 0 0 0 0.001746 0.007476 0 0.037292 0 0 0.000574 0.006166For Peer0 0.000408 0.005334Review0 0.041487 Only3.52E-13 5.78E-08 1.47E-07 0 0 0.000945 0.005559 0 0.082461 0 0 0 0 0.047081 0.000273 0.006118 0.039654 0.19991 0.002284 0.001985 0 0 0 0.000274 0.003875 0 0.221373 0 0 1.97E-05 0 0 0.001816 0.012085 0 0.037278 0 5.59E-07 0 0 0 0.001205 0.003104 0 0.190661 0 0.000417 0 0 8.08E-05 0.000156 0.00167 0 0 0.008258 0.005148 0 0.020781 0.00027 0.000244 0.000848 2.01E-05 0.043688 0.000572 0.00023 0 1.04E-14 0.005363 6.45E-05 0.00788 0 0.03263 0.010333 8.46E-09 0 0 0.023659 1.54E-09 0.000976 0 0 0 0 0.000631 0.029417 0 0.001335 0.01674 0 0 8.01E-12 0.00192

Wiley-Blackwell and Society for Applied Microbiology Page 230 of 848

Salmonella Acidobacteriumenterica subsp.Pyrococcus entericacapsulatum Francisellasp. serovar OT3-30 strain Dublin tularensisMycobacterium ATCC strain 51196-08 subsp.Helicobacter CT_02021853-01 bovis novicida BCGGeobacter hepaticus U112-01 strain PasteurbemidjiensisErwinia str. ATCC 1173P2-01 pyrifoliae 51449-01Petrotoga strain strain Bem-30 mobilis Ep1/96-30 strain SJ95-08 0 0.081016 0 0.025784 0.000852 0.000125 0.054675 0.001615 0.016403 0 0 0 0.027198 0 0 0.000125 0 0 0 0.001642 0 0.01493 0 3.00E-05 9.66E-05 0 0 0.002551 0.000257 0 0.034222 0 7.52E-09 1.01E-05 0.010678 0 0 0.004236 0 0.021049 0 4.05E-06 0.006437 0.00123 0 0 0.001257 0 0.023016 0 0.000794 0 0 0 0.00119 0.01136 0 0.023495 0 0.000241 0.010336 0.000648 0 0 7.55E-07 0 0.029824 0 1.76E-05 0.000561 0 0 0 0.000114For Peer0 0.018344 Review0 0.000122 0.000105 Only0.003877 0.000315 0 0.000186 0.070825 0.012508 0 6.49E-06 0.003455 0.03048 0.003535 0 0.000937 0 0.033436 0 0.002847 3.10E-19 9.64E-05 0.002187 0 0 0 0.024348 0 1.08E-05 0.000667 0.016099 0 0 0.001595 0.018332 0.031025 0 0.006921 0 6.82E-05 0.00802 0.000531 0.000163 0 0.010336 0 0.00059 8.37E-05 0.002461 0 0 0.01655 0 0 0 0.002398 0.04532 0.010789 0 0 0.001824 0 0.021186 0 0.001423 0.002585 0.014432 0 0 0.015658 0 0 0 0 0.029008 0.001805 0.0122 0 0.001276 0 0.012597 0 0.000137 0.000585 0.003225 0 0.001837 0.002741 0 0.015222 0 0.001717 0 0.007658 3.35E-06

Wiley-Blackwell and Society for Applied Microbiology Page 231 of 848

PseudomonasPseudomonas fluorescensEscherichia stutzeri str. SBW25-30 Carboxydothermusstraincoli strain A1501-08 ATCCBacillus 8739-08 tusciaehydrogenoformansThermus strain thermophilus DSMPasteurella 2912-01 str. Z-2901-01 Methanocaldococcus multocidastrain HB27-30 subsp.Shewanella multocida fervens pealeana strain strain strain Pm70-08 AG86-01 ATCC 700345-08 0.06167 0.156082 0 0.034567 0.005643 0 0.005052 0.00667 0.035329 0.019978 0.346659 0 2.53E-05 7.90E-11 0 0 0 0.099378 0.046982 0.098421 0 1.33E-05 0.000108 0 0 0.000596 0.012388 0.159884 0.227136 0 0 1.57E-09 0 0 0 0.040564 0.034672 0.070946 0.00071 9.66E-05 7.98E-05 6.43E-05 0 0 0.017076 0.080491 0.29984 0 0.001117 3.70E-10 0 0 4.92E-09 0.05969 0.056619 0.107634 0 0.006594 9.44E-05 0.021676 0.006893 1.52E-15 0.018531 0.082038 0.366724 0 0.00131 0.001153 0 0 0 0.086399 0.02711 0.064888For Peer0 0.000223 5.61E-05Review0.002407 Only0 0 0.011864 0.018297 0.252145 0 0.000607 0.001122 0 0.079968 0 0.085852 0.056985 0.425087 0 0.002111 0.000158 0 0.095688 0.001879 0.073997 0.081968 0.173107 0 0.00011 9.89E-05 0 0 0 0.040193 0.036258 0.392783 0.001342 0.000287 1.95E-06 0 0.108605 0 0.097877 0.00237 0.034067 0 0.003478 0.000365 0 0 0 0 0.027949 0.13413 0 0.010373 0.002245 0.000544 0 9.64E-05 0.025059 0.039608 0.073045 0 6.54E-05 0.000144 0 0.01059 0 0.007302 0.033187 0.133484 0.000946 0.011785 0.000997 0.00498 0.008149 1.12E-05 0.030303 0.02507 0.127981 0 4.85E-07 8.68E-06 0 0 0 0.030728 0.043845 0.345726 0.000997 3.37E-05 1.56E-06 0 0.100171 0 0.080373

Wiley-Blackwell and Society for Applied Microbiology Page 232 of 848

SynechocystisStreptococcus sp.PCC6803-08Rickettsia pneumoniae rickettsiiBacillus strain cereusstrain HalorubrumHungary19A-6-01 Iowa-01 strain AH820-08Legionella lacusprofundi pneumophilaThermococcus strain ATCCRuthia str. sibiricus 49239-08 Lens-08 magnificaChloroflexus strain str. MM Cm 739-30 aurantiacus (Calyptogena strain magnifica)-01 J-10-fl-01 0.036852 0 0 0.001052 0.00802 0.034278 0 2.844399 0.015723 0.038006 0 0 0 0 0 0 1.51575 0 0.011664 0 0 0 0 0 0 2.018294 0 0.007736 0 0 0 0 0 0 1.423369 0 0.003519 0 0 0 0 0 0 0.154037 0 0.013974 0 0 0.000177 0 0.049367 0 4.431703 0 0.01812 0 0 0 0 0.02328 0 4.008741 0 0.019513 0 0.002207 0.002738 0 0.019809 0 5.17525 0 0.007518 For0 Peer0 0 Review0 0 Only0 0.836704 0.000416 0.009722 2.68E-08 0.000915 0 0 0 0 3.467268 0 0.016961 0 0 0.000431 0 0.017154 0 3.045354 0.000638 0.04311 0 0 0 0 0 0 0.190257 2.60E-06 0.01262 0 0.002916 0 0.000511 0.03586 0 3.149426 0 0.009312 0 0 0 0.000184 0.004594 0 0.563762 0 0.000467 0 0 0 0 0.027278 0 5.211948 0 0.0092 0 0 0 0 0.012093 0 0.256223 0 0.004106 0 0 0 0.006121 0.022511 0.000937 3.780023 0.002109 0.008265 3.76E-05 0.001374 0 0 0 0 0.226162 0 0.008152 0 0 0 0 0.018323 0 3.428311 0

Wiley-Blackwell and Society for Applied Microbiology Page 233 of 848

HelicobacterBuchnera pylori strain aphidicola[Mesorhizobium] Shi470-01 str.Xylella Sg (Schizaphis sp. fastidiosa BNC1-08Petrotoga graminum)-08 str. Temecula1-01mobilisBordetella strain aviumErwinia SJ95-01 strain tasmaniensisDickeya 197N-30 dadantii strainCorynebacterium Et1/99-01 strain Ech703-08 jeikeium strain K411-30 0 0 0.111624 0 4.34E-05 0.010705 0.000964 0.016083 0 0.000229 0 0.026387 0.000524 0 0 4.66E-05 0.051083 0 0 0 0.035332 0.001465 0.000297 0.003798 0.0004 0.00464 0 6.26E-10 0 0.046715 0 0 0 0.002176 0.016676 0 2.08E-07 0.037977 0.025266 0 5.05E-08 0.000507 0.002728 0.005213 0 1.47E-10 0 0.049987 0.001651 0.001467 0.034559 0.001489 0.009614 0 0 0 0.075431 0.003968 0 7.04E-06 0.002952 0.005934 1.63E-09 1.64E-09 0 0.068042 0 0 0 0.002415 0.022457 0 0 0.008317For0.032598 Peer0 Review0 0.001582 Only0 0.004197 0 8.70E-11 0 0.02668 0 0 0 0.001304 0.016026 0 5.31E-05 0.016576 0.03225 0 0.000138 0.020433 0.001777 0.02287 0 2.36E-09 0 0.027514 0 0 0.017425 0 0.020436 0 0.000603 0.031306 0.053535 0.004431 0 0.003056 0.003115 0.037614 0 1.01E-05 0 0.002969 0 2.41E-12 0 0.003013 0.006177 0.000472 0 0 0.089205 0 0.00053 0.017492 0.002017 0 0 0 0.014521 0.020309 0 0.000203 0.012827 0 0.010825 0.00402 0.000366 0.018345 0.055069 0.003193 0.002328 0.004363 0.002155 0.005808 0.000124 3.57E-07 0 0.033337 0.000356 3.35E-10 0.000515 0.000424 0.004841 0 1.55E-07 0.086115 0.050377 0 0 0.012354 0.002452 0.030605 0.009398

Wiley-Blackwell and Society for Applied Microbiology Page 234 of 848

Yersinia pestisEhrlichia strain ruminantium PestoidesClostridium F-01 gamma straintetani Gardel-08 str. proteobacterium E88-01Rickettsia akariLactobacillus MLHE-1-08 strain Hartford-08Thermotoga rhamnosusStreptococcus sp. strain RKU-1-30 Lc Caldicellulosiruptor705-30 suis strain BM407-30 saccharolyticus strain DSM 8903-01 0 0 0.002681 0.225522 0 0 0 0 0.005194 0 0 0 0.050038 0 0 0 0 5.63E-09 0.000267 0 4.63E-09 0.060774 0 0 0 0 3.39E-07 0 0 0 0.078823 2.81E-07 0 0 0 0 0 4.33E-05 0.00014 0.036882 0 0 0 0 0.000919 0 0 8.61E-05 0.113415 0 0 0 0 0.000271 0 0 0.000935 0.100311 0 0 0 0 0.000166 0 0 3.83E-06 0.125003 0 0 0 0 5.41E-06 0 For0 Peer0 0.024973 Review0 0 Only0 0 0.000336 0 0 0 0.089584 0 0 0 0.095741 0.000244 0.000946 0 8.38E-05 0.094323 0 0 0 0 0.000104 0 0 3.24E-07 0.052039 0 0 0 0 3.02E-05 0.00381 0 0 0.123558 0 0 0 0 0 0 0 5.51E-05 0.018925 0 0 0 0 0.000102 0 0 0.001498 0.119709 0 0 0 0 0.001179 0.000125 0 9.75E-06 0.039048 0 0 0 0 0.000471 0.00251 0.008226 0.001117 0.085135 0 5.97E-08 1.27E-06 0 0.002044 0 0 0 0.03737 0 0 0 0 3.18E-07 0 0 6.14E-06 0.129151 0 0 0 0 0.000163

Wiley-Blackwell and Society for Applied Microbiology Page 235 of 848

Francisella tularensisThermosipho subsp.Prochlorococcus africanus novicidaRhodobacter strain U112-08 sp. TCF52B-30 MIT9312-08Rhodospirillum sphaeroidesBifidobacterium strain centenum ATCCMethanococcus strain17029-30 dentium SW-01Staphylococcus strain vannielii Bd1-01Streptococcus strain carnosus SB-01 subsp. mitis strain carnosusstrain B6-08 TM300-01 0.129853 0 0.024611 0.000464 0.079788 0 0.000164 1.20E-05 0.022971 0.118052 0 0 0.074601 0.004578 0 0 0 0.014624 0 0 0.001623 0.129361 0.005641 0 0 2.16E-11 0.016957 0.046004 0 0.002352 0.467709 0.00469 0 1.98E-08 0 0 0.040417 0 0.012145 0.319043 0.013623 1.24E-10 8.78E-05 3.66E-05 0.010737 0 0 0.003021 0.169233 0.011939 2.25E-08 0 0.000156 0 0 1.41E-05 0.005333 0.055225 0.042821 0 0 0.001405 0 0.04644 0 0.026731 0.074686 0.006812 0 0 0 0 0.01754 For0 0.012058 Peer0.103467 Review0.0215 0 8.75E-05 Only 0 0 0 0 0.009607 0.119696 0.006547 0 0 3.36E-13 0.013165 0.132988 0 0 0.266801 0.008119 0 0.000341 0 0.004589 0.09129 0 0.005384 0.051972 0.018751 0 0 0 0 0 0 0.003288 0.083187 0.010552 0.000249 0.000208 0 0 0 0 0 0.038446 0.031042 0 0.000125 0.001424 0.006707 0 0 0.000115 0.068428 0.031227 0.000173 0.000418 0.000527 0 0.023615 0 0.018792 0.057241 0.020218 0 0 0 0.002219 0.080983 0 0.006693 0.043317 0.026406 1.23E-08 0.001218 0.000931 0.005192 0 0 0.006218 0.142882 0.006854 0 0 0 0 0.05686 0 0.009467 0.093398 0.010745 1.54E-15 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 236 of 848

PseudomonasVerrucomicrobiae fluorescensNeisseria strain bacterium gonorrhoeae Pf-5-30Bacillus V4-30 cereusPyrococcus strain strain FA 1090-08Q1-30 Shigellaabyssi strain sonneiHerminiimonas GE5-08 strain Ss046-30Dickeya arsenicoxydans zeaeDesulfatibacillum strain Ech1591-08 Muller et alkenivorans al. 2006-08 strain AK-01-08 0.006762 0 0 0 0.011401 0 0.049321 0.005871 0.043282 0.035748 0 0 0.000971 0 0 0.038236 0.008113 0.005347 0.015291 0 0.002769 0 2.03E-07 0 0.034374 0.003924 0.00098 0.111293 0 0 0 0 0 0.019327 0.011228 3.14E-05 0.019982 0 0 0.008368 0 0 0.015408 0.005649 0.000495 0.101444 1.18E-11 0.007579 2.61E-05 0 0 0.036785 0.006064 0.007387 0.023926 0.028479 0 0 6.59E-05 0 0.035943 0.008668 0.009727 0.024402 4.95E-11 0.003392 0 0 0 0.018133 0.004507 0.00481 0.048117 9.77E-11For Peer0 0 Review0 0 0.016891 Only0.009451 0.004482 0.032202 0 0 0.000154 0 0 0.033834 0.020153 0.002927 0.058865 0 0 0 0 0 0.063387 0.008901 0.00196 0.02918 0 0 0 0 0.002259 0.010293 0 0 0.054834 0 0 0 0 0 0.076205 0.011697 0.00727 0.001423 0.017178 0 0 0.003278 0 0.001605 0.00159 0.000163 0.03645 0.07136 0 0.014938 0 0 0.037131 0.010448 0.01118 0.039312 0.057809 0.00608 0 3.62E-05 0 0.015779 0.006262 0.004341 0.010901 0.081443 0 0.001709 0.006273 0 0.035186 0.005458 0.020166 0.095606 0 0.007268 0 0 0 0.017583 0.006628 2.39E-05 0.041255 0 0 0 0 0 0.041367 0.017574 0.004253

Wiley-Blackwell and Society for Applied Microbiology Page 237 of 848

MycobacteriumChlamydophila avium Klebsiellastr. pneumoniae104-01 pneumoniaeJonesia J138-08 denitrificansMetallosphaera strain 342-30 strainChlorobium DSMsedula 20603-01Escherichia straintepidum DSM strain Thermoanaerobactercoli 5348-01 strain TLS-01 HS-08Enterobacter pseudethanolicus sakazakii ATCC strainBAA-894-30 ATCC 33223-30 3.68E-05 0 0.000268 0.000474 1.43E-15 0.03679 0 0 0 1.11E-08 0 0 5.39E-09 0 5.26E-05 0 0 0 7.12E-05 0 0.004235 4.52E-08 0 0.00202 0 0 0 2.16E-13 0 0.009188 0 0 6.11E-05 0 0 2.63E-12 5.97E-05 0 0.000592 0.000554 0 0.000172 0 0 0.002035 0.000647 0 0.04795 9.89E-05 0 0.002448 0 0 0.079192 0.000316 0 0 0 1.64E-12 0.003563 0 0 0 0 0 0 0 0 0.004257 0 0 0 0 For0 0.005256 Peer1.28E-06 Review0 0.000746 Only0 0 0.007802 2.55E-05 0 0.005127 0.000879 0 0.004644 0 0 0.020596 3.84E-05 0 0.008139 0.000836 2.97E-06 0.002679 0 0 0.000179 0.000368 0 0.028181 0.000376 0 0.000423 0 0 0.040581 0 0 0 0 0 0.004634 0 0 0.019682 0.000299 9.24E-08 8.21E-19 0.000348 0 0.003787 0 0 0.00251 0.000105 0 0.000367 0.000299 4.47E-11 0.002222 7.72E-09 0.012885 1.18E-06 0 0 0.003117 0.000383 0 0 0 0 0.021518 0.000147 0 6.07E-05 0.000534 4.09E-09 0.007367 0 0 0.006173 0 0 0 1.74E-06 0 0.000356 0 0 0.018662 3.32E-05 0 0.006378 3.83E-11 0 0.004068 0 0 0.014497

Wiley-Blackwell and Society for Applied Microbiology Page 238 of 848

EnterobacterNeorickettsia sakazakiiBacteroides ATCC sennetsu BAA-894-01Thermotoga str.thetaiotaomicron Miyayama-08Vibrio sp. TMO-01 sp. strain Ex25-30Frankia VPI-5482-30 sp. BurkholderiaEAN1pec-08bacterium thailandensis Ellin345-01Streptomyces strain E264-08 griseus subsp. griseus strain NBRC 13350-08 0.000176 0.023216 0 0 0.005588 0.008936 4.51E-05 0.032924 0.014291 0 0 0 0 0.063289 1.27E-06 0.003827 1.27E-06 0 0.000251 0 0.014767 0 0 0.003031 0.0019 0.000287 0.00164 0.002338 0 0 0 0.073295 0 2.42E-08 2.76E-08 0 0.000764 0 0.0142 0.000577 0.050892 6.28E-05 0.000538 0.000262 0.001112 0.001478 0 0 0.00104 0.069708 0.000562 0.002197 0.000119 0 0 0 0.027706 0.001458 0.027013 0.002751 0.003459 0.004256 0.000436 0.001321 0 0 0 0.173135 0.000427 0.00797 0.000856 0.00348 0.00075 For0 0.006735 Peer0 Review0 0.00142 0.000942 Only0.000155 1.88E-09 0.001054 0 0 0 0.052945 0.002644 0.000709 0.000267 0.001397 0.000654 0 0.023805 4.88E-09 0.075635 0.002821 0.00659 0.000829 0.000519 0.001518 1.66E-05 0.015384 0.000336 0.101121 0 0.001526 0.000307 0 0 0.010282 0.006464 0 0 0.00157 0.00646 0.00111 0.002007 0.00096 0 0.001055 9.85E-05 0.002055 0.000153 0 0.000294 0 0.001506 0 0.045881 7.53E-06 0.020576 0.005674 0.007572 0.001871 0.000158 0.000218 0 0.001097 9.71E-05 0.023258 0.001105 0.000969 2.06E-05 4.36E-05 0.000958 0.005514 0.011118 0 0.017272 0.005261 0.00228 0.003679 0.007211 0 0 3.49E-06 0 0.06277 0 0.001835 0.000589 0 0.002385 0 0.003155 3.36E-05 0.057595 0.000361 0.001822 9.74E-05 0.000168

Wiley-Blackwell and Society for Applied Microbiology Page 239 of 848

MycobacteriumSalmonella marinum Leptospiraenterica strain subsp. M-30 biflexaDehalococcoides enterica serovarCorynebacterium serovar Patoc ethenogenes strainParatyphiConexibacter Patoc1-08 diphtheriae strain A strainChlamydophila woesei 195-01 AKU_12601-01 NCTC13129-01 strainGloeobacter caviae DSM 14684-08 str.Rhodococcus violaceus GPIC-01 strain sp. RHA1-08 PCC 7421-08 2.23E-08 0.001338 0.058416 0.029547 1.71E-05 0.028738 0 0.022747 0.01209 0 4.09E-10 0 0 0 0.00548 0 0.010313 0.001211 0 0 0.000624 0 3.12E-05 0.000969 1.22E-24 0.004457 0.002902 0.030536 0 0 0 0 0 0 0.001316 0.005942 0 0 0 8.29E-17 0 0.003913 0 0.001552 0.003518 1.72E-06 0 0 0 0 0.005129 0 0.000448 0.006949 0 0 0 0.001835 2.02E-05 0.001564 0 0.006624 0.005712 0.001924 0 0.00114 0.001265 0.000103 0.004807 0 0.000905 0.008507 0.00086 0.00082For0.002063 Peer0 Review0 0.002637 Only0 0.005521 0.001158 0 0 0.005252 2.34E-09 0 1.23E-12 0 0.005725 0.008052 0 0 0.003411 0 0.001545 4.35E-05 0 0.005793 0.011106 0.000886 0.001299 0 0 0 0.000358 0 0.034829 0.001956 0 0 0.010836 0 0 0.004857 0 0.006594 0.009991 0.000938 0 0.002019 0.000555 0.00031 0.001738 0 0.001312 0.00356 0.000515 0 0.008041 0.001012 0 0.023513 0 0.010991 0.005085 1.44E-05 0.000595 0 0 0.000744 0.006345 0 0.008295 0.001647 0.004026 0 0.018421 0.000992 3.61E-06 0.006774 0 0.007286 0.002235 0 0 0 0 0 0 0.001212 0.00679 0.004981 0.005831 0 0.005336 0 0 0.000922 0 0.009512 0.005071

Wiley-Blackwell and Society for Applied Microbiology Page 240 of 848

DesulfotomaculumSalmonella acetoxidans Salmonellaenterica subsp.strain Edwardsiellaenterica DSMenterica subsp. 771-01Neisseria tardaserovar enterica strain meningitidis GallinarumThermoanaerobacter serovar EIB202-01 Typhistrain Synechococcusstrain str. 287/91-01 alpha14-08 Ty2-30 tengcongensisuncultured sp. PCC6301-08 ClostridiumTermite strain groupMB4-08 botulinum 1 bacterium A2 strain phylotype Kyoto-01 Rs-D17-01 0.006076 0 0 0.001653 0 0.030612 0 0.003565 0.000272 9.78E-05 3.17E-10 0 0.000115 0 0 0 0.003307 7.18E-05 5.00E-05 0 0 0.000984 0 0 0 0 1.15E-08 0.000481 0 0 0.001597 0 0 0 0 1.88E-10 0.000474 0 0 0.001951 0.007016 0.00071 0 0.000761 2.11E-05 0.000468 0 0 0.003225 0.033226 0.00737 0.023797 1.29E-06 2.00E-06 0.000898 0 0 0.004871 0 0.001231 0 0 2.95E-05 1.36E-05 0 0 0.003287 0.01158 0 0.121651 5.25E-05 0 0.000427 For0 Peer0 0.001758 Review0 0 0.01651 Only 0 3.53E-05 0.000712 0 0 0.00269 0.018883 0.000509 0 0 1.13E-05 0.000167 0 0.030535 0.003024 0 6.72E-09 0 0.000475 0.000177 0.000207 0 0.013836 0.001968 0.027934 0 0 0.000868 2.68E-05 2.09E-05 0.003891 0.000367 0.007607 0.022087 0 0.027333 3.26E-07 0.000115 0.000308 0.00049 0 0.000753 0 0 0.038677 4.19E-07 6.66E-05 0.000102 0 0 0.00079 0 0 0.018965 0.001124 0.000362 0.00057 0 0 0.000825 0.004828 0.004442 0.034686 4.46E-09 1.61E-05 0.000864 0 0.000992 0.002198 0.026527 0.01198 0.007034 0.002901 7.90E-05 1.74E-05 0 0.005208 0.000677 0.019184 0 0 0 7.49E-06 0.000189 0.001922 0.010027 0.005373 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 241 of 848

CorynebacteriumMethanococcus glutamicumEscherichia maripaludis strain Chloroflexuscoli R-08 strain strain E24377A-30Ehrlichia C5-01 aggregans canisThermoanaerobacter strain strain DSM Jake-08Deinococcus 9485-30 tengcongensisThermotoga geothermalisLactococcus sp. strain strain RKU-10-01 MB4-01 DSM lactis 11300-30 subsp. cremoris strain MG1363-01 0 0.000392 0 0.033924 0.022898 0.018028 0 0.000336 0 0.00029 0 0 0 0 0 0 0 0 0.000137 0 0 0 0 8.22E-13 0.002333 0 0 0 1.08E-05 0 0.000203 0 0 0.011987 0 0 8.72E-19 0 0 0 0 0.000276 0 0 1.74E-05 0.002243 0 0 0 0 2.17E-07 0 0 0 0 0 0 0.025006 0 0.000161 0 0 1.46E-05 0.002707 0 0 0 0 2.85E-09 0 0 0 0 For0 Peer0 0.0014 Review0 0.000106 Only0 0 0 0.000314 3.09E-05 0 0.000362 0.002061 0 0.004696 0 0 7.24E-05 2.62E-05 0 0.021565 7.45E-25 0.000515 0.000888 0 0.002069 0 0 0 0 0 0.00075 0.000451 0 0.000566 0.000543 0 0 0.033312 2.91E-05 1.66E-12 0.001529 0 0 0 0 0 0 0 0.000431 0.017091 3.54E-06 0 0 0.000255 0 0.000856 0 0.003248 0.002155 0 0 0 0 0 0.001017 0 0.000558 0.014554 9.29E-07 0 0.002674 5.82E-05 0.004394 0.007522 0 0.002026 0.00419 0 0 0 0 1.55E-06 0.047386 0 4.43E-08 0.010512 0 0 2.36E-09 0.000854 0 0.00125 0 0.000299 0 9.25E-26 0

Wiley-Blackwell and Society for Applied Microbiology Page 242 of 848

DesulfovibrioAminobacterium vulgaris strainBacillus 'Miyazakicolombiense weihenstephanensisXylanimonas F'-30 strainPseudomonas cellulosilytica DSM strain 12261-08Pseudomonas KBAB4-30 fluorescens strain DSMAmmonifex aeruginosa str. 15894-30 SBW25-01Clostridium degensii strain strainPA7-30Lactobacillus botulinum KC4-30 A3 plantarum strain Loch strain Maree-08 WCFS1-01 0 0.013217 0 0 0.010539 0.031868 0 2.58E-05 6.01E-06 0 0 0.001056 0 0.003862 0.009817 0 0 0 3.89E-05 0 4.23E-05 0 0.005829 0.02348 0 0 0 0 0 0 0 0.012234 0.16127 0 0.000794 0 0 0 0 0 0.006419 0.029639 0 0 0 0 0 1.10E-05 0 0.015371 0.073842 0 0 3.73E-15 0.002072 0 0 0 0.007892 0.023121 0 0 0 0 0 0 0 0.01058 0.028871 0 0 0 0 For0 Peer0 0.001878 0.003055Review0.03664 Only0 0.000574 0 0 0 6.25E-05 0 0.008105 0.046192 0 1.57E-17 0 0.038022 9.13E-05 0 0 0.011042 0.070117 0 0 0 0 0 0 0.000941 0.008221 0.073196 0 0 0 0 0.001177 0 0 0.026854 0.047146 0 1.97E-05 0 0 0 0 0 0.002317 0.010451 0 0.000372 0 0.016251 0.012597 0 0.00201 0.005864 0.051101 4.15E-06 0 0.000275 0.000358 0 0 9.29E-06 0.003447 0.066071 0 0 0 0.007767 0.006178 0.004544 0.002421 0.011867 0.01682 0.004603 0.002673 7.23E-09 8.14E-11 0 0 0 0.003904 0.076538 0 0 0 0 0 0 3.79E-09 0.022843 0.061324 0 0.000631 0

Wiley-Blackwell and Society for Applied Microbiology Page 243 of 848

ThermococcusHalorhabdus onnurineusEscherichia utahensis strain NA1-01 Dickeya fergusoniistrain DSM zeae strainCampylobacter 12940-08 strain ATCC Ech1591-01 Mycobacterium35469-30 jejuni subsp.Wautersia abscessus doylei eutrophaEscherichia strain strain 269.97-01 H16-08 ATCC Desulfovibriocoli O111:H-19977-01 strain desulfuricans 11128-01 subsp. desulfuricans strain G20-30 0.001898 0 0 0.000356 0.001207 0.006132 0.033174 0.002619 0 0 0 0 1.83E-06 6.57E-30 0.000343 0.012646 0.000148 0 0 0 0 0.000307 0.000204 0.000519 0.00334 0 0.022316 0 0 0 0.001388 0 0.000996 0.00801 0 0.035723 0 0 0 0.000836 0.000266 0.000172 0.006112 0.000879 0.002218 0 0 0 0 0.000309 0.00059 0.018022 0 0.201064 2.43E-12 0 0 0.003798 0.001099 0.000352 0.012842 0.001143 0.049584 4.70E-11 0 0 0.001944 9.61E-05 0.00159 0.033044 0.00141 0 0 For0 Peer0 0.000867 0.000393Review0.000313 0.003495 Only 0 0.011634 0 0 0 0.001515 2.30E-12 0.000883 0.016128 0 0 2.53E-12 0 0 0.001419 0.000354 0.001717 0.020821 0 0.117864 0 0 0 0.001823 9.56E-15 0.00077 0.000418 0 0 0 0.00033 0.004638 0.004015 3.53E-06 0.000915 0.020693 0 0.080245 1.35E-05 0.00026 0.000116 0.001247 1.48E-17 0.0005 0.00251 0 0.036296 2.05E-06 0 0 0.002031 0.0002 2.63E-05 0.014952 0 0.015266 0 0 0.003306 0.000534 0.000385 0.000288 0.003487 0.00037 0.019428 0.002121 0 5.32E-09 0 0.000349 0.001136 0.018636 0.000572 0.014006 0 0 0 0.000419 0.000187 0.000807 0.004698 0 0.06546 0 0 0.012536 0.001922 0.001672 0.001563 0.017313 0.001712 0

Wiley-Blackwell and Society for Applied Microbiology Page 244 of 848

BlattabacteriumAcetobacter sp. (PeriplanetaCandidatus pasteurianus americana) PasteurellaAccumulibactor IFO 3283-01-08 strain Borreliamultocida phosphatis BPLAN-30 afzelii subsp.Lactobacillus strain Type multocida PKo-01 IIAMicrocystis rhamnosus str. strain UW-1-30Oligotropha aeruginosaPm70-30 strain Lc Coxiella705-08 NIES-843-01carboxidovorans burnetii str. strain RSA OM5-01493-08 0 0.060264 0.08396 0.042896 4.18E-05 0 0.002097 0.019271 0 0 0.115303 0 0 0 1.30E-05 0.002122 0.000901 0.025985 0 0.017783 0.000272 0.000174 3.26E-12 0 0.001411 0.003403 0 0 0.005196 0.01475 0 0 0 3.93E-10 0.002062 0 0 0.010561 0.016224 0 0 0 9.34E-06 0.006491 0 0 0.06282 0.069239 0.192851 3.77E-12 1.86E-05 0.002034 0.004583 0 0 0.010064 0.018202 0 0 0 0.000449 0.008406 0 0 0.033449 7.44E-08 0 0 0 0.000953 0.003973 0 0 0.004493For0.010504 Peer0 Review0 0 0.000518 Only0.010522 0.018368 0 0.011497 0.000292 0.001976 0.000675 0 0.000421 0.001285 0 0 0.009904 0.041415 0 0 0 0.00036 0.004042 0 0 0.016948 0.023272 0.069211 8.05E-11 0 0.000976 0.00508 0 0 0.010841 0.000383 0 0 0 1.05E-06 0.007004 0 0 0 0.010459 0 0 0 0.002383 0.009492 0 0 0 0.070599 0 0 0.008126 0.000731 0.014494 0 0 0.016722 0.008574 0 8.62E-11 0 0.0006 0.007427 0 0.164673 0.033216 0.01758 0.017069 0 0 0.002133 0.010425 0 0.000931 0.000815 0.009564 0.104966 0 0 0.000967 0.001991 0 0 0.011453 0.001114 0 0 5.12E-06 0.000122 0.006446 0

Wiley-Blackwell and Society for Applied Microbiology Page 245 of 848

Clavibacter CampylobactermichiganensisCandidatus subsp. jejuni subsp.michiganensis PseudomonasSulcia jejuni muelleriAnaplasma strain strainaeruginosa strain 81116-08 NCPPB DMIN-08 Thermodesulfovibriomarginale str. 382-08 PAO1-01 strainProchlorococcus Florida-01 yellowstoniiFrancisella sp. NATL2A-30 tularensis SanguibacterDSM 11347-30 subsp. keddieii mediasiatica strain DSM strain 10542-30 FSC147-08 0.001219 0 0 0.008962 0 0 0 0.026669 0 0.003427 0.005673 0.103355 0.002075 0.000117 0 0 0 0 0 0 0.02687 0.005495 0 0 0.040547 0 0 0 0 0.292272 0.013865 0 0 0.028979 0 0 0 0 0.1008 0 0 0.022867 0.01613 0 6.57E-08 0 0 0.036396 0.015575 0 0 0 0 0 0.007548 0 0 0.01162 0 0.000782 0.00764 0.021407 0 0.014889 0 0.110759 0 0 0 0 0.017667 0 0 3.15E-20For Peer0 0.006943 Review0 6.19E-10 0.013098 Only0.025108 0.000287 0 0 0.04517 0.009822 4.18E-05 0 3.16E-08 0 0 0 0 0 0.008494 0.001032 0 0 0 0 0 0 0 0.011537 0 0 0.010707 0 6.01E-08 0 0.002753 0.104367 0.037686 0.000247 0 0.037211 0 0 0 0 0.047159 0 0 0 0.008961 0 0 0.000118 0 0 0.008374 0.002334 0.056362 0 0 3.38E-08 0.002024 0.001479 0.038242 0.00379 0 0 0.00845 0.011213 0.000375 0.000443 0 0.021248 0.010732 0 0.049249 0.009473 0 0.000672 1.19E-06 0 0.039579 0.002938 0 0 0 0 5.53E-05 0 0 0 0.028661 5.77E-07 0 0.005056 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 246 of 848

StreptococcusThermoanaerobacter zooepidemicus-30Halobacterium italicusShigella salinarum strain flexneriExiguobacterium Ab9-30 strain serotype R1-08Comamonas 2a strainstr. 301-08Burkholderia 255-15-30 testosteroniStreptococcus mallei strain strainCNB-2-30Acetobacter equi SAVP1-08 subsp. pasteurianus equi strain IFO4047-08 3283-01-30 0 0 0 0 0 0.018065 0.002451 0 0.109271 0 0 0 0 0 0 0.00178 0 0.735282 0 0 0 0 0.011721 0.001127 0.002609 0 0.049996 0 0 0 0.008604 0 0.023359 0.000477 0 0.041266 0 0 0 0 0 0.032229 0.001309 0 0.092764 0 0 0 0.025024 0 0.002455 0.001346 0 1.351799 0 0 0 0 0.019525 0 0 0 0 0 0 0 0 0.162225 0 0.005109 0.000182 0.165212 0 For0 0.000389 Peer0 4.05E-06Review0.001654 0.000852 Only 0 0.011868 0 0 0 0 0 0 0.001878 0.000946 0.147489 0 0 0 0 0.072208 0 0.001785 0.001054 0.16052 0 0 0 0 0 0.019807 0.002915 0 0.164932 0 0 0 0.033877 0 0.021637 0.005896 0.000196 0.061888 0 0 0.000427 0 0 0.001851 0 0 0.100512 0 9.31E-23 8.88E-06 0 0 0.052058 0.002516 2.58E-09 0 0 0 0 0 5.22E-12 0.011341 0.001227 0 0.053077 0 0.011333 0 0 0.007586 0.008687 0.001056 0 0.021819 0.085245 0 0 0 0 0.006191 0.000759 0 0.088052 0.019852 0 0 0 0 0.000446 0.002244 0 0.053284

Wiley-Blackwell and Society for Applied Microbiology Page 247 of 848

HyphomonasBrucella neptunium suisAllochromatium strain strain ATCC ATCCRickettsia 23445-30 15444-08 vinosum africaeThermosipho strain ESF-5-30 DSMBacillus melanesiensis 180-08 anthracisYersinia strain strain pestisAeromonas BI429-08 CDC biovar 684-08 OrientalisBurkholderia salmonicida strain subsp.pseudomallei IP275-01 salmonicida strain strain K96243-30 A449-08 0.142237 0 0.081931 0 0 0 0.061295 0.013905 0.061838 0.075698 0 0.088996 0 0 0 0 0.03403 0 0.062337 0.009186 0.038367 0 0.000193 0 0 0.019276 0.026571 0.103756 6.85E-05 0.063448 0 0 0 0 0.034688 0.021943 0.041514 0.008338 0.03829 0 0 0 0 0.015838 0.00741 0.095749 0 0.105886 0 0 0 0 0.052612 0.008204 0.060635 0 0.084882 0 0 0 0 0.0155 0.014037 0.118601 0 0.124464 0 4.03E-06 0 0 0.045725 0.227588 0.025155 For0 0.02103 Peer0 0.001191Review0 Only0 0.017839 0.000416 0.040795 0 0.099129 0 0.003451 0 0 0.055213 0.006904 0.078188 0 0.12418 0 0 0.000444 0 0.053849 0.040761 0.046058 0 0.046825 0 0 0 0 0.037065 0.011849 0.124648 0 0.162445 0 0.000942 0 0 0.084212 0.056387 0.007583 0.017673 0.02101 0 0 0 0 0.00726 0.000632 0.107367 0.03132 0.153497 0 0 0 0 0.042793 0.003129 0.026312 0.010914 0.041191 0 0 0 0 0.007223 0.007592 0.085395 0 0.115698 0.012945 0.007394 0.001104 0 0.025664 0.008875 0.053596 0 0.049012 0 0 0 0 0.021696 0.004473 0.065697 0 0.131624 0 1.72E-05 0 0 0.052288 0.00086

Wiley-Blackwell and Society for Applied Microbiology Page 248 of 848

ActinobacillusActinosynnema pleuropneumoniaeCaldivirga mirum maquilingensis Erwinia serovarstrain DSM pyrifoliae7 strainHerpetosiphon 43827-30 strain AP76-08 strain IC-167-30Francisella Ep1/96-01 aurantiacus tularensisThermanaerovibrio DSM subsp.785-08Verminephrobacter tularensis acidaminovoransShigella strain boydii eiseniae FSC198-01 strain strain DSMCDC EF01-2-30 3083-94-08 6589-30 0 0.001388 0 0.003513 0.036871 0 0 0.133592 0 0.007043 0.001183 0 6.41E-05 0.005136 0 0 0 0 0 0.00169 0 0.000635 0.001882 0 0.001753 0.001557 0 0 0 0 0.001843 8.45E-07 0 0 0.023501 0 0 0 0 0 3.61E-12 0 0.000154 0.017456 0 0 0 0 0 2.45E-07 0 0 0.00609 0 0.016793 0 0 0.002946 0.000152 0.010098 0 0.032227 0 0.01889 8.49E-05 0 0.002839 8.39E-11 0 0 0 0 0 For0 Peer0 0.003645 2.22E-06Review0.004512 Only0 0.005912 0 0.016028 0 0 0.001474 0.001412 0 0 0.001732 0 0.034367 0 0 0.003177 9.00E-05 0 0 0.004246 0 0 0 0 0.004173 4.28E-05 0 0 0.005786 0 0 0.001046 0 0.002915 0.001128 0 0 0.007412 0 0.020299 0.000517 0 0 6.91E-05 0.002604 0 0.000684 2.45E-08 0 0.01013 0.003679 0 0.008103 0 0.015366 0.018348 0 0.010891 0 0 0 0.003037 0 0 0.007265 4.50E-08 0.018499 0.000574 0 0.001447 0.006214 0 0.017229 0.014417 0 0.00979 0.018022 0 0 2.38E-05 0 0 0.000723 0 0 0 0 0.002819 0.002502 0.002484 0 0.005854 0.002824

Wiley-Blackwell and Society for Applied Microbiology Page 249 of 848

endosymbiontCaldicellulosiruptor of AcanthamoebaHaemophilus saccharolyticus sp.Anaeromyxobacter influenzaeUWE25-08Salmonella strainRd KW20-01 DSMdehalogenans Rhizobiumtyphimurium 8903-08 sp.Thermoplasmastrain LT2-01 ORS571-30 2CP-1-08Streptococcus volcaniumSalmonella pneumoniae strain GSS1-30 enterica strain subsp. Hungary19A-6-08 enterica serovar Paratyphi A strain AKU_12601-30 0.025375 0.023856 0.00013 0.021723 0 0.007886 0 0 0 0 0 0.001308 0 0 0 0 0 0 7.52E-06 0 0.002272 0.00173 0.000399 0.042206 0 0 0 9.22E-05 0 0 0.003254 0 0.039203 0 0 0 0 0 0 6.50E-09 0 0.038687 0 0 0 0.008204 0 0 0.000357 0 0.014792 0 0 0 0 0 0.007331 0.005512 0 0.022032 0 9.11E-05 0 0.016575 0 0.00571 0.002405 0 0 0 0 0 0.004971 0.004295For Peer0 0.000574 Review0 0.015955 Only0 0 0 0.00176 0 0.002182 0.001282 0 4.46E-09 0 0 0 4.39E-06 0 0 0.001874 0 4.99E-10 0 0 0 0 0 0.004092 0.009115 0 0.004966 0 0 0.010739 4.57E-07 0 0 0.000979 0 0.021401 0 0 0 0.008285 0 0.001112 0 0 0.007043 0 0 0 0.017136 0 0.004761 0.007683 0 0.019915 0 0 0 0.000104 0 0 0.000662 0 0.00266 0.008394 0 0 0.009223 0.00627 0 0.007389 0 0.026791 0 0 0.000363 0.002213 0 0 0 0 0.036081 0 0 0 0.000418 0 0.006474 2.15E-12 0 8.69E-05 0 0 0.007637

Wiley-Blackwell and Society for Applied Microbiology Page 250 of 848

StreptococcusBurkholderia agalactiaeCytophaga malleistr. 2603V/R-01 strain hutchinsoniiAster SAVP1-30 yellowsStreptococcus strain witches'-broom ATCCPectobacterium 33406-08 pneumoniae phytoplasmaLactobacillus carotovorastrain str. DesulfotomaculumTaiwan19F-14-30 plantarumAYWB-01 subsp.Buchnera atroseptica strain WCFS1-08acetoxidans aphidicola str. SCRI1043-30 strain DSM5A (Acyrthosiphon 771-30 pisum)-01 0 0 0.094723 0 0.01419 0.008151 1.15E-05 1.62E-05 0 0 0.007556 0.074322 0 0 0.006072 0 0 0 0 0.014591 0.116988 1.97E-09 0 0.007301 0 0 0 0 0.011009 0.056755 0 0 0 0 2.46E-06 0.033485 0 0.001097 0.063957 0 0 0.003749 0 1.77E-05 0 0.000255 0 0.063361 8.04E-05 0 9.81E-06 0 0 0.005789 0 0.005044 0.098103 0 0 0 0 0.022461 0 0 0.090714 0.144414 0 0 0 0 0 0.005603 0 0.000831For0.045513 Peer0 Review0 0.005472 Only0 0.008439 0.012642 0 0.010956 0.093104 0 0 0.026956 0 0 0.01278 0.000434 0.075946 0.060558 0 0 0.050467 0 0 0 0 0.012536 0.101117 0 0 0.024769 0 0 0 0 0.024607 0.087732 0 0 0.019703 0 1.04E-05 0 0 0.013617 0.015746 0 0 0 0 0 0.014763 0 0.008593 0.119595 0.000976 0 0.001913 0 0.0263 0 0 0 0.030821 0 0 0.007865 0.001147 0.000548 0.006815 0 0.001686 0.048317 7.35E-14 0 0 0 0.001126 0.006568 0 0 0.025661 0 0 0.039448 0 0 0.002388 0 0.001437 0.076191 0 0 0.002066 0 0.01857 0.007276

Wiley-Blackwell and Society for Applied Microbiology Page 251 of 848

Anaplasma Erwiniaphagocytophilum tasmaniensisXylella str.fastidiosa strain HZ-08Pseudomonas Et1/99-08 strainShewanella M23-08 putida str.Gramella putrefaciens KT2440-08 forsetiiRhodobacter strain strain CN-32-01Rhizobium KT0803-08 sphaeroides radiobacterBurkholderia strain ATCC K84-08 mallei 17025-08 strain SAVP1-01 0 0.012503 0.008372 0.02797 0.00156 0.266984 0.038521 0.037492 0.000547 2.42E-16 0.015612 0 0.103972 0.000237 3.122766 0.132495 0.025198 0.000209 6.51E-05 0.008084 0 0.029408 0.001066 2.017053 0.4566 0.046781 0.000168 0 0 0 0.056154 0.000733 1.622868 0.553955 0.0615 0 0 0.004823 0 0.01827 0 1.514523 0.532685 0.032712 0 0.002689 0.014071 0.003753 0.104508 0 2.525715 0.244211 0.048743 0.000464 0 0.002915 0.003222 0.032858 0.002085 0.946525 0.207833 0.047353 0 0 0.00286 0 0.114994 0.003929 3.672386 0.207046 0.055848 7.77E-05 0 For0 Peer0 0.01841 Review0 0.842067 0.174585 Only0.013205 0.000305 0 0.011526 0.010421 0.080807 0.003567 3.353387 0.171002 0.031031 0.00044 0.003097 0 0.01036 0.096416 0 2.059762 0.160449 0.045187 0.000468 0 0.010558 0.027428 0.061966 0.002144 2.327748 0.401522 0.038854 0 0 0 0 0.146251 0 2.54503 0.309238 0.071801 0.000791 0 0 0.001059 0.003979 0 0.32994 0.063851 0.009806 0 0 0 0.006075 0.031673 0.004082 0.940194 0.220911 0.05194 0 0.000347 0.002195 0.004262 0.017995 0 0.228097 0.12648 0.026435 0 0 0.004257 0 0.020839 0.004021 0.646509 0.176674 0.048853 0.000725 0 0 0 0.032566 0 1.510166 0.29516 0.035518 4.06E-06 0.001745 0.025588 0.015717 0.110641 0.005913 2.113981 0.346641 0.048453 0

Wiley-Blackwell and Society for Applied Microbiology Page 252 of 848

PseudoalteromonasClostridium haloplanktisSlackia tetani str.heliotrinireducens strainE88-30Erythrobacter TAC125-01Hyphomonas litoralis strain DSM strainRhodopseudomonas neptunium 20476-08 HTCC2594-30Burkholderia strain ATCC palustrisHelicobacter vietnamiensis 15444-01 strainActinobacillus pylori TIE-1-30 strain strain G4-01 Shi470-08succinogenes strain 130Z-30 0.28365 0 0.00036 0.44397 0.042971 0.029572 0.000377 0 0 0.023504 0 0 0.006208 0.001902 0 0.001264 0 0 0.010006 0 0 0.048434 0.004421 0.000385 0.000857 0 0.001409 0.049839 0 0 0.104735 0.013971 0.005965 0.002788 0 0 0.014159 0 0 0.129072 0.01013 0.012025 0.000306 0 0 0.03863 0 5.18E-11 0.094376 0.006842 6.22E-06 0.001439 0 0.0957 0.031042 1.23E-05 0 0.030411 0.016368 0.013419 0.001188 0 3.23E-14 0.03602 0 0 0.222858 0.007611 1.99E-05 0.000592 0 0 0.01977 For0 Peer0 0.084782 0.006311Review0.010744 0.000215 Only 0 0.062735 0.02133 0 8.60E-05 9.16E-10 0.008367 0.001124 0.000427 0 0 0.021311 0.067215 0 0.108786 0.005712 0.011361 0.001203 0 0.027505 0.016745 0 0 0.163515 0.008743 0.002522 0.000561 0 0.032608 0.057239 0 0.000553 0.126733 0.011979 6.07E-08 0.002319 0.006777 0.065128 0.0157 0 0 0.061069 0.011849 0.007368 0.000583 0 0.003145 0.018764 2.51E-14 0 0.065465 0.01372 0.024788 0.001589 0 0.010445 0.006985 0 0.002744 0.163319 0.005885 0.003298 0.000231 0.005704 0.020427 0.025299 0.001036 0.00329 0.046891 0.026822 0.01259 0.001914 0 0 0.016196 0 0 0.100403 0.005998 0.003523 0.000461 0 0 0.047546 0 0.008514 0.053477 0.021239 0.000693 0.002341 0 0.017511

Wiley-Blackwell and Society for Applied Microbiology Page 253 of 848

ShewanellaHaloferax violacea strain volcaniiClostridium DSS12-01 strainHelicobacter sp. DS2-08 OhILAs-30Haemophilus pylori strainDesulfitobacterium influenzae J99-08 Acidothermus Rd KW20-08 hafniensePorphyromonas cellulolyticus DSMKlebsiella 10664-08 gingivalisstrain pneumoniae 11B-30 strain W83-01 strain 342-08 0.010785 0.003108 0 0 0 0.01111 0.072894 0.007987 0 0.00828 0 0 0 0 0 0 0 0.003982 0.010267 0 0 0 0.002977 0.002239 0.027497 0.002385 0.002333 0.017804 0 0 0 0 0 0.003949 0.006342 0 0.008351 0 0 0 0.01371 0 0.000714 0.003293 0.002144 0.017524 0 0 0 0 0 0.154137 0.007923 0 0.016329 0 0 0 0 0 3.34E-07 0.007597 0.004309 0.013034 0 0 0 0 0.00601 0 0.005906 0.011919 0.005786 For0 Peer0 0 0.02329Review0 Only0 0.002096 0 0.016957 0 0 0 0.023446 0 0.000396 0.007137 0.007603 0.015223 0 0 0 0.023047 0 0 0.00992 0.007088 0.009515 0 0 0 0 0 0 0.007521 0 0.02868 0 0 0 0 0.000447 0 0.005721 0.008279 0.003348 0 0 0 0 0 0 0.008232 0.001219 0.010497 0.003019 0.006586 0 0 0 0.017878 0 0 0.003198 0 0.011601 0 0.010252 0.003224 0 0.003566 0 0.014007 0.001357 0.012419 0.010367 0 0.014734 0.023296 0.003101 0 0.004564 0 0 0 0 0 0 0 0 0.025354 0 0.005917 0 0 1.03E-05 0.013559 0.010184 0.005914

Wiley-Blackwell and Society for Applied Microbiology Page 254 of 848

Pseudomonassulfate-reducing putida str.Bacteroides KT2440-01 bacteriumSalmonella vulgatus Hxd3-08 strain Rhizobiumenterica ATCC subsp. 8482-08leguminosarumLactobacillus entericaEdwardsiella reuteriserovar bv. trifolii strain DublinHelicobacter tarda strain JCM strain strain 1112-08 WSM1325-01Burkholderia CT_02021853-30 pylori EIB202-30 strain sp. P12-30 383-08 0.005691 0.044298 0.021507 0 0.007535 0 0.000279 0 0.003736 0.002189 0 0.012035 0 0.001025 0 0 0 0.006099 0.004081 0.000292 0.020111 0 0.001901 0 0.007024 0 0.001897 0.009168 0.00747 0.009782 0 0.00293 0 0.015768 0 0.004326 0.004328 0.001823 0.0132 0 0.002894 0 0.018313 0 0.002264 0.012744 0.006067 0.007289 0.152521 0.00161 0 0.052957 0 0.004699 0.007635 0.011955 0.017121 0 0.004574 0 0.014708 0 0.001808 0.009495 0.005404 0.019368 0 0.004651 0 0.117566 0 0.019478 0.003281 0.003675For0.012845 Peer0 0.001502Review0 0.00243 Only 0 0.00169 0.006794 0.00722 0.011932 0 0.002069 0 0.007683 0 0.011185 0.008236 0.000543 0.029313 0 0.001868 0 0.019024 0 0.01579 0.007488 0 0.030962 5.35E-05 0.00374 0 0.053005 0 0.002145 0.028977 0.008836 0.014637 0 0.005834 0 0.007715 0 0.013154 0.002894 8.86E-05 0.002841 0 0.003962 0 0.001095 0 0.001272 0.005914 0.038844 0.005071 0 0.002756 0 0.006195 0 0.001729 0.002697 0.002865 0.004142 0 0.000818 0.001418 0.009046 0 0.002469 0.008217 0.010015 0.007867 0 0.002988 0 0.007465 0.002092 0.007738 0.001839 5.02E-10 0.003922 0 0.001319 0 0.083753 0 0.004392 0.020128 0.005098 0.011951 0 0.006333 0 0.00392 0 0.010919

Wiley-Blackwell and Society for Applied Microbiology Page 255 of 848

StreptococcusPyrococcus thermophilus Caldivirgafuriosus strain strain maquilingensisCorynebacterium LMD-9-30 DSM 3638-08Treponema strain efficiens IC-167-08Pyrococcus pallidum strain subsp.YS-314-08 Desulfobacteriumsp. OT3-01 pallidumCronobacter strain autotrophicum SS14-01Rhizobium turicensis sp. strainz3032-01 ORS571-01 HRM2-01 0 0 0 0.010337 0 0.024975 0.009771 0.00016 0.01771 0 0 0 0 0 0 1.46E-06 7.89E-05 0.004706 0 1.75E-07 0 0 0 2.01E-05 0.000483 0.000309 0.002253 0 0 0 0.000806 0 0 0.0017 0.001922 0.002794 0 0 0 0 0 0 0.001174 0.00125 0.00451 0 0 0 0 0 0 0.002015 0.003029 0.003107 0.005033 0 0 6.78E-13 0 5.01E-18 0.004185 0.00411 0.005541 0 0 0 0.001061 0 4.77E-12 0.001419 0.001027 0.006502 0 For0 Peer0 0 Review0 0 0.00052 Only0.000561 0.005611 0 2.80E-10 0 0.000257 0 0.000108 0.000726 0.001048 0.003577 0 0 0 0.000114 0 7.78E-05 0.001662 0 0.005 0 0 0 0 0 0 0.000821 0.001067 0.006123 0 0 0 0.005941 0 1.46E-07 0.001523 0.003096 0.005866 0 0 0.005319 0 0 5.70E-05 0.000118 0.001549 0.0107 0 7.62E-08 0 0.000135 0 6.72E-07 0.001103 0 0.005726 0 0 0 0 0 0 0.000515 0 0.009396 0.011037 0.001187 0 0.000621 0.00155 0.000604 0.009067 0.001968 0.008937 0 0 0 0 0 0 0.000427 0.000499 0.00231 0 0 0 0.003124 0 0 0.002762 0.00275 0.004341

Wiley-Blackwell and Society for Applied Microbiology Page 256 of 848

DesulfitobacteriumMarinobacter hafnienseRickettsia hydrocarbonoclasticus DSM massiliaeAeromonas 10664-01 strainsulfate-reducing salmonicida VT8-30MTU5-01Blattabacterium subsp. bacterium salmonicidaLegionella Hxd3-01sp. Alboraia-30 strainpneumophilaCellvibrio A449-01 japonicusAnaplasma strain Corby-30strain marginale Ueda107-30 subsp. centrale str. Israel-08 0.003523 2.338489 0.01157 0.010121 0.018707 0 0 0.147344 0 0 0.075955 0 0.001823 5.57E-06 0 0 0.281078 5.98E-18 0 0.14279 0.006198 0.003253 0.001226 0.112378 0 0.38683 0 0 0.849413 0 0.003128 6.95E-17 0 0 0.836808 0 0 0.273871 0 0.004664 0.000821 0.2098 0.020466 0.314446 0.00109 5.88E-05 0.367922 0 0.009683 0.001434 0 0 0.481812 0 0.00105 0.182897 0.005365 0.012248 0.000992 0 0 0.248935 0 1.07E-05 0.397145 0 0.007569 1.89E-08 0 0 0.529582 0 1.01E-05 0.460928For Peer0 0.003849 0.000399Review0 Only0 0.313451 0 6.02E-05 0.349559 0.001237 0.006474 0.001113 0.124488 0.007187 0.639073 0 0.00064 0.623996 0 0.004739 0.00284 0 0 0.382211 0 1.53E-06 0.796891 0.003791 0.004526 0.000706 0 0 0.551326 0 0 0.410406 0.006567 0.014325 0.001067 0 0 0.458549 0 5.07E-05 0.119226 0.00612 0.002506 0.0012 0 0 0.049828 0.008997 0.000504 0.461623 0.001874 0.00426 0.002277 0 0 0.423258 0 2.39E-05 0.536291 0.002821 0.002014 0.000587 0.053282 0.008514 0.32294 0.005448 0 0.397604 0 0.007947 0.002532 0 0.008457 0.194166 0 7.66E-07 0.250304 0 0.000822 2.41E-06 0 0 0.43388 0 0 0.340075 0.002157 0.012052 0.000947 0 0 0.420813 0.00033

Wiley-Blackwell and Society for Applied Microbiology Page 257 of 848

marine firmicuteSulfurospirillum HTE831-30Erwinia deleyianum tasmaniensisEscherichia strain strain Clostridiumcoli DSM strain Et1/99-30 6946-08 536-01Thermotoga botulinum MethanosphaeraA sp. strain TMO-30 Hall-08Prochlorococcus stadtmanaekorarchaeote marinus strain OPF1-KOR-01DSMsubsp. 3091-30 marinus str. SS120-01 0 0.007967 0 0 0 0 0.000423 0.001392 0.001113 0 0.010819 0 0 0 0 0 0.002524 0 0 0.011881 0.000788 0 0 0.00563 0 6.59E-05 0 0 0.000392 0 0 0 0 0 0 0 0.002638 0.005124 0.002698 0 0 0 0 4.67E-09 0 0 0 0.167366 0.000325 0 0 0 0.001355 0 0 0.007065 0 0 0 0 0 0.000266 1.07E-13 0 0 0 0 0.009064 0 0 0.002122 0 0 For0 0.004203 Peer0 0.000736Review0 Only0 2.84E-05 0 0 1.22E-06 0.006336 0 0 0 0 0.000666 0 0 0.004417 0.004767 0 0 0 0 0.001416 0 0 0 0.019123 0 0 0 0 0.002089 0 0 0.001039 0.002888 0 0 0 0 0.002286 0 0 0 0 0 0 0 0.000163 0.001819 0.000233 0 0.00138 0.007773 0 0 0 0 5.76E-06 1.15E-10 0 0 0.012695 0 0 0 0 0.000716 0 0.002091 0.004608 7.49E-07 0.000215 0 0 8.63E-09 0.001001 1.49E-05 0 0 1.59E-07 0 0 0 0 4.91E-09 0 0 0.023319 0.002715 0 0 0 0 0.001934 0

Wiley-Blackwell and Society for Applied Microbiology Page 258 of 848

ClostridiumYersinia botulinum pestis AcinetobacterA3 strain KIMLochRhizobium 10-08baumannii Maree-01 radiobacterShewanella strain AB0057-01Burkholderia denitrificansK84-30 Deinococcus thailandensisstrain OS217-08Rubrobacter geothermalis strain E264-01Dehalococcoides xylanophilus strain DSM strain 11300-08 sp. VS-08DSM 9941-30 0.000277 0 0 0.014021 0.025593 0.002669 0.012899 0.071029 0.056419 0 0 0.000887 7.97E-06 0.086421 0.000628 0 0 0 1.09E-08 0 0.002244 0.055061 0.012776 0.000441 0.000688 1.86E-08 0 1.78E-10 0 0.003052 0.051308 0.054417 0 0.000341 0.046515 0 2.48E-05 0 0.002262 0.022846 0.021777 0.000839 0.001211 0.013664 0 0 0 0.006578 0 0.065921 0.000254 0.000232 0.115076 0 0.000375 0 0.006395 0.011664 0.025604 0.000603 0.00201 0.056294 0.000515 0 0 0.004916 0.001915 0.046117 1.51E-05 0.000782 0 0 0.000336 0.000873For0.002686 Peer0.014823 0.021213Review0.000281 0.000207 Only 0 0 1.07E-05 0 0.005296 0.000216 0.053806 0.000652 0.0069 0.000102 0 0.000138 0 0 0.034525 0.07115 0.000598 0.002646 0 0 3.73E-05 0 0.005599 0.002322 0.049538 0.000181 0.001121 0 0 0.00011 0 0.006603 0.009796 0.086411 0.001301 0.014498 0.029387 0 0.000193 0 0.00204 0.009032 0.005776 0.000224 0.004313 0 0 0.000498 0 0.004616 0.027928 0.024054 0.000292 0.007591 0.000175 0 1.54E-05 0 0.00241 0.004607 0.018131 0.000697 0.005707 5.52E-05 0 7.52E-05 0.010187 0.004383 0.027801 0.011262 0.001232 0.003709 0.030351 0.017008 4.12E-06 0 0 0.035126 0.021392 0.000174 0.000475 0.045569 0 1.10E-05 0 0.006518 0.011033 0.07888 0.001441 0.00176 0.002216 0

Wiley-Blackwell and Society for Applied Microbiology Page 259 of 848

Brucella ovisBurkholderia strain ATCCTrichodesmium sp.25840-08 STM815-30Mycobacterium sp. IMS101-01Bifidobacterium gilvumCytophaga strain longum PYR-GCK-30 hutchinsoniiCarsonella-Pv-08 str. DJO10A-30Petrotoga strain ATCC mobilisRhodobacter 33406-30 strain SJ95-30sphaeroides strain KD131-08 0.074641 0 0.000367 0 0 0.185847 0 0 0.046574 0.027063 0 0.010156 0 0 0.066825 0 0 0.115263 0 0.008949 0.010778 0.012371 0 0.160046 0 0 0.290135 0 0.013825 0.011832 0 0 0.151379 0 0 0.383132 0.078473 0.003413 0.007156 0.007659 0 0.117314 0 0 0.293729 0 0 0.007527 0.000938 0 0.118566 0 0 0.19089 0 0.000746 0.008028 0 0 0.189284 0 0 0.118505 0.024018 2.72E-06 0.007975 0.000275 0 0.308223 0 0 0.173159 0 0.001434For0.014449 Peer0.006412 Review0 0.054586 Only0 0 0.118642 0 0.000114 0.006726 0 0 0.058749 0 0.056754 0.116396 0 7.79E-06 0.009839 0 0.032892 0.0001 0 0 0.111794 0 0.00019 0.009982 0.001811 0 0.013446 0 0 0.294751 0.021102 0.000144 0.006358 0.003176 0 0.176145 0 0 0.252536 0 4.15E-05 0.009573 0.001918 0 0.049494 0 0 0.051073 0 0.002191 0.006535 0.000519 0 0.269623 0 0 0.143721 0.023135 2.53E-07 0.014934 7.47E-05 0.002268 0.060062 0 0 0.086857 0 0.006217 0.004834 0.007226 0 0.214324 0.029777 0.01385 0.115027 0 2.77E-06 0.007023 0 0 0.098927 0 0 0.266339 0.052276 0.005445 0.014972 0.005152 0 0.099601 0 0 0.280448

Wiley-Blackwell and Society for Applied Microbiology Page 260 of 848

CorynebacteriumAeropyrum diphtheriaeAggregatibacter pernix NCTC13129-08strainSaccharomonospora K1-30 aphrophilusStreptosporangium strain viridisShigella NJ8700-08 strain boydiiroseum DSMCyanothece strain 43017-30strain CDC CandidatusDSM sp. 3083-94-01 BH68K-30 43021-30 BacillusAmoebophilus pseudofirmus asiaticus strain strain OF4-01 5a2-01 0 0 0.00541 0.040863 3.31E-14 0 0 0.006527 0.000617 0 0 0.066783 0 0 0 0.255501 0.002102 9.70E-08 0 0 0.001527 0 0.000321 0 0.01767 0.004976 2.55E-05 0 0 0 2.33E-07 0 0 0 0.003106 0.003403 0 0 0.009628 0.000984 0 0 0 0.002356 0.003113 0 0 0.022278 0 0 0 0.277886 0.001278 0.000545 0 0 0.009964 0 0.012289 0.000145 0.042586 0.005656 0.00017 0 0 0.035884 0 0 0 0.177648 0.00378 0.000767 0.003084 For0 Peer0 0 0.003713Review0.000171 0.007641 Only0.001524 0.00063 0.000459 0 0.019995 0 0 0 0.114456 0.007352 0.001885 2.78E-06 0 0.027922 0 0 0 0.036569 0.018841 0.001354 0 0 0 0 0 0.000225 0.033229 0.002785 0.002033 0 0 0.042305 0 0.009 0 0.105119 0.009539 0.000993 0 0 0 2.61E-08 0 0 0.084914 0.001179 0.00128 0 9.56E-11 0 0.020949 0.023687 0 0.000205 0.004628 0.001096 0 0 0.017929 0.001565 0.006366 0 0.018352 0.002423 0.000873 0 2.38E-11 0.010017 0.025321 0.010917 0 0.012929 0.005447 0.001083 0 0 0.014809 0 0 0 0.006743 7.21E-06 0.000596 0.002929 0 0.041788 0.011192 0.000188 0 0.135346 0.004588 0.000211

Wiley-Blackwell and Society for Applied Microbiology Page 261 of 848

Bacillus thuringiensisThermobaculum serovarNocardioides terrenum konkukianepsilon sp. strain JS614-01 strain proteobacterium ATCCBrucella 97-27-08 BAA-798-30 sp.Synechococcus CCM AmH-30 4915-30Aeromonas sp. PCCMycoplasma 7424-01hydrophilaPorphyromonas subsp. mycoides hydrophila subsp. gingivalis mycoidesstrain ATCC strain SC 7966-01 strain W83-30 PG1-08 0 0 0.01352 0 0 0.012241 0.008444 0 0 0 0 0.000636 0.483177 0 0.001293 0.002528 0 0 0 0 0.000199 0.065231 0.002933 0.001478 0.003102 0 0.078366 0 0 7.15E-06 0.079487 0 1.03E-05 0.009814 0 0 0 7.30E-06 0.000887 0.010154 0.025021 0.000811 0.005022 0 0 1.38E-11 0 0.00056 0 0 0.001092 0.01183 0 0.055207 0 4.79E-05 0.002404 0.109032 0.043801 0.001043 0.010551 0 0.086555 0 0 0.000831 0.554418 0.017561 0.000241 0.010875 0 0 0 For0 0.000736 Peer0 Review0 0.000128 0.003746 Only 0 0 0 0 0.000637 0 0 0.000342 0.005489 4.73E-10 0.070459 0 0.069998 0.001246 0.513734 0.065869 0.000732 0.005037 0 0 0 0 1.77E-05 0 0 0.000693 0.00451 0 0.00038 0 0.063789 0.000631 0 0 5.84E-08 0.014796 0 0.042577 0 0.017364 0.000741 0.033103 0 0.001824 0.002054 0 0 0 0.003796 0.001803 0.022117 0 0.000443 0.004617 0 0 0 0.000885 2.93E-05 0 0 0.000136 0.003359 0 0.037727 7.99E-08 0.034253 0.000977 0.011424 0 0.001447 0.008631 0 0.049824 0 0.095375 1.96E-07 0 0 2.43E-05 0.001101 0.008771 0.04932 0 0 0.000611 0 0.07497 0.000163 0.015036 0 0.00073

Wiley-Blackwell and Society for Applied Microbiology Page 262 of 848

Vibrio choleraeBifidobacterium strain M66-2-08Zymomonas longumCampylobacter mobilis subsp. infantissubsp.Yersinia jejuni mobilis strain enterocolitica subsp.Acinetobacter ATCC strain jejuni15697-08 ZM4-01 Shewanellasubsp. strain baumannii enterocolitica81-176-01Zymomonas sp. strain MR-4-08 ACICU-08 strainShewanella mobilis 8081-08 subsp. violacea mobilis strain strain DSS12-08 NCIMB 11163-08 0 0 0.009573 0.000613 0.00696 0.020703 0.017239 0 0.071589 0 0 0 0 0 0.048052 0.034753 0.00018 0.093288 0.00232 0 0 0.000208 0 0 0 0.010005 0.041478 0.02985 0 0.00121 0 0 0 0 0.014672 0.078609 0 0 0 0 0 0 0.011609 0 0.036313 0 0 0.001841 0.000778 0.03257 0.048912 0.032605 0 0.115237 0.000479 0 0.010062 0.000383 0 0.013681 0 0.015715 0.050032 0.025887 0 0.00073 9.80E-05 0.017306 0 0 0 0.101573 0 For0 0.003273 Peer0 Review0 0.035002 Only0 0.037227 0.026998 0 0 0 2.35E-12 0.019578 0.022279 0 0.000309 0.09882 0 0 0 0.000362 0.024361 0.037018 0.023156 0.000111 0.120165 0 0 0.003883 9.75E-15 0 0 0 0 0.062176 0 0 0.001894 1.78E-13 0.024907 0.038092 0.035905 0.004177 0.146569 0 0 0.0082 1.51E-17 0.002033 0 0 0 0.006177 0 0 0.004556 0.000204 0.016553 0.011325 0.019349 0.00991 0.070274 0 0.001567 0 0 0.004154 0.012796 0.007625 0 0.023218 0 0 0 0.000225 0.007547 0.012012 0.015343 0 0.044782 0.005586 0 0.00131 0.000191 0.00111 0 0 0 0.05048 0 0 0 7.38E-14 0.020212 0 0.024796 0.012455 0.109425

Wiley-Blackwell and Society for Applied Microbiology Page 263 of 848

StreptosporangiumBaumannia roseumCapnocytophaga cicadellinicola strain EscherichiaDSM str. 43021-01ochracea Hc (Homalodisca Haemophiluscoli strainO127:H6 DSMBurkholderia strainparasuiscoagulata)-08 7271-30 E2348/69-30 Prochlorococcusstrain cepacia SH0165-30 str.Lactococcus J2315-01 sp. MED4-30Methanocaldococcus lactis subsp. lactis strain sp. FS406-22-30 Il1403-30 0.008298 0 0.533168 0 0 0.002151 0 0 0 6.55E-05 0 0.316211 0 0 0.000457 0 0 0 0.000301 0 0.953953 0 0 0.000901 0.022555 0 0 1.21E-06 0 0.754687 0 0 0.001053 0.080372 0 0 0.001399 0 0.659267 0 0 0.000798 8.65E-15 0 0 0.000437 0.062895 0.499567 0 0 0.001394 0.114676 0 0 0.000666 0 0.689631 0 0.036141 0.002074 0 0 0 3.44E-05 0 0.46344 0 0 0.001026 0.077002 0 0 0.00029 For0 0.469641 Peer0.003584 0.005286Review0.000835 0.029007 Only 0 0 7.31E-06 0 1.044373 0 0.012349 0.000889 0 0 0 2.11E-05 0 0.535019 0 0 0.001414 0 0 0 0.000158 0 0.408494 0 0.080692 0.000938 0.005763 0 0 3.94E-05 0 1.320706 0 0 0.001676 0 0.009612 0 0.000789 0 0.439036 0 0.048889 0.001019 0.003617 0 0 0.001673 0 0.530674 0 0 0.00186 0 0 0 0.000809 0 0.309008 0 0 0.000281 0.23223 0.002687 0 0.000211 0 0.449117 0 0.011245 0.001199 0.000759 0 0.000218 5.27E-07 0 0.378963 0 0.011856 0.000533 0.046027 0 0 0.000336 0 0.811302 0 0.090254 0.002514 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 264 of 848

BeijerinckiaHaloquadratum indica subsp.Parvibaculum indica walsbyi straincyanobacterium strain lavamentivorans ATCC DSM 9039-08Methanococcus 16790-01 UCYN-A-30 strainGeobacter DS-1-08 aeolicus sp.Actinosynnema strain FRC-32-08 Nankai-3-08Finegoldia mirum magnaShewanella strain strainDSM amazonensis43827-08 ATCC 29328-01 strain SB2B-08 0.048297 0.000426 0.335879 0 0 0.034077 0.000538 0.005294 0.026542 0.002251 0 0.027574 0 0 8.47E-15 0 0 0.121272 0.029039 0.000714 0.116783 0 0 0.000601 0.000131 0 0.028309 0.008995 0 0.055315 0 0 0 0 0 0.057624 0.003674 2.72E-12 0.08147 0 0 0.000565 5.54E-08 0.000157 0.034628 0.009387 7.54E-11 0.055672 0 1.46E-06 0.000544 0.001147 0.000299 0.110644 0.013952 1.14E-06 0.225022 0 0 0.005417 0.001982 1.99E-19 0.063727 0.007007 2.45E-19 0.150346 0 0 0.001411 3.95E-05 0.000546 0.140588 0.013565 0.000663For0.12399 Peer0 6.78E-11Review0.004628 0.00022 Only3.50E-16 0.017202 0.006998 0 0.04755 0 0.000209 0.003979 0.001092 0 0.122222 0.005181 0.000556 0.063547 0 0.00079 0.001263 5.46E-05 0.001508 0.155815 0.011478 1.09E-11 0.073551 0 0 5.32E-05 5.01E-07 0 0.102206 0.021359 0 0.083403 0.269158 0.008219 0.008586 2.90E-05 0 0.186199 0.003999 3.37E-07 0.057429 0 0 0.000938 0 6.47E-05 0.005843 0.029204 1.16E-07 0.242291 0 0 0.018266 2.47E-05 0.002694 0.045479 0.02135 8.75E-23 0.092668 0 4.81E-05 0.003341 0.000636 0 0.025085 0.033209 3.64E-07 0.306296 0 0.001318 0.029493 0.001991 0.002519 0.052828 0.005759 0 0.029272 0.127715 0 0.00045 0 0.000106 0.057208 0.018533 4.44E-17 0.070705 0.151078 7.20E-05 0.001443 6.77E-05 0 0.135889

Wiley-Blackwell and Society for Applied Microbiology Page 265 of 848

EnterococcusDichelobacter faecalis str.Methylotenera V583-01nodosusSynechococcus str. mobilisVCS1703A-01Xanthomonas strain sp. JLW8-08strainHaloterrigena RF-1-08 campestrisRhodococcus turkmenicapv. campestrisBacillus erythropolis strain strain anthracis DSMNeisseria B100-30 strain5511-30 strain gonorrhoeaePR4-01 'Ames Ancestor'-08 strain NCCP11945-30 0.000123 0.018047 0 0.015839 0 0 0.001064 0 0 8.74E-09 0.001043 0.066355 0.010922 0.353778 0 0 0 0 1.31E-09 0.001382 0.082522 0 0.02013 0.000152 4.56E-06 0 0 0.002023 0.003982 0.061174 0.002645 0.015143 0.001101 0.001299 0 0 3.17E-09 0.013648 0.055741 0 0.014025 8.77E-05 0.000335 0 0.007017 5.86E-05 0.008609 0 0.006184 0.175767 0 0.000953 0 0.087748 2.93E-05 0.018041 0.032465 0.015757 0.017309 0 0.000478 0 0 0 0.020316 0.087966 0.013575 0.393274 0 8.39E-05 0 0 0 0.009802For0.070331 Peer0.005124 0.006478Review0 5.80E-12 Only 0 0.024455 4.13E-05 0.004073 0.094917 0.009579 0.085465 0 9.31E-05 0 0.012687 2.34E-05 0.010273 0.105221 0.00238 0.370172 0 0.00026 0 0 0 0.014789 0 0.018072 0.020794 0 0.0003 0 0 0.000108 0.017409 0.072006 0.003221 0.017122 0 0.000716 0.000258 0.008011 0 0.009699 0 0.010399 0.016278 0 0.000156 0 0.021649 0.001286 0.018255 0.05963 0.006721 0.031635 0.002283 0.000185 0 0.024928 0 0.005012 0.040851 0.006732 0.040273 0 0.000332 0 0.016543 0.000606 0.020893 0.079877 0.005576 0.025146 0.000248 0.000172 0 0.00236 7.28E-06 0.003318 0.043749 0.004968 0.019788 0 0.000154 0 0 0 0.008739 0.12529 0.008183 0.028231 0 0.000221 0 0.000855

Wiley-Blackwell and Society for Applied Microbiology Page 266 of 848

AkkermansiaBurkholderia sp. Muc-08Ignicoccus pseudomallei sp.Nostoc Kin4-I-30 strain sp. PCC73102-01MSHR346-30Escherichia Clostridiumcoli UMN026-08Vibrio botulinum harveyi ClostridiumB strain strain Eklund ATCCMycobacterium difficile BAA-1116-30 17B-08 strain CD196-01 tuberculosis strain H37Rv-08 0.334362 0.160946 0 0.001425 0 0.008466 0.043752 0 0 0.00011 0 0 0.001587 0 0.009056 0.119719 0 0 0.026554 0.026068 0 0.000616 0.001453 0 0.0007 1.37E-05 0 0.00675 0.04104 0 8.32E-13 0 0 0.146573 0.003037 0 0.00681 0.013807 0 0.00033 0 6.61E-07 0.037335 1.10E-05 0 0.009277 0.136804 0 0.001207 0 0 0.063797 0.000348 0 0.087468 0.003994 2.26E-19 0.00059 0 0 0.01398 0.001171 0 0.004075 0.226015 0 4.00E-05 0 0 0 2.28E-05 0 0.064201 0.004091For Peer0 0.000312 Review0 0 0.033457 Only1.31E-13 0 0.012022 0.011568 0 0.00167 0.004321 0.000234 0.024101 0.00026 0.000261 0.003262 0.020856 0 0.000664 0.002698 0.00201 0.07173 0 0 0.069763 0.004053 0 0.000659 0 0 0.118025 0 0 0.000585 0.022295 0 0.00024 0 0.000426 0.047022 0 0 0.053624 7.38E-09 0 0.001248 0.005374 0 0.023739 0.000608 0 0.184216 0.020918 5.54E-18 8.40E-05 0.004558 0.001999 0.014261 0 0 0.147988 0.002856 0 4.30E-05 0 0.000286 0.068831 0 0.001093 0.10023 0.005077 2.11E-24 0.000753 0.001276 0.002049 0.007625 0 0 0.000108 0.002262 0 6.21E-07 0 0.002762 0.074654 0 0 1.08E-05 0.002278 0 0.000372 0 5.43E-05 0.02068 4.70E-05 0

Wiley-Blackwell and Society for Applied Microbiology Page 267 of 848

bacterium CBDB1-01RhodopseudomonasMethanopyrus palustrisBurkholderia kandleri strainPectobacterium str. pseudomalleiCGA009-08 AV19-30bacterium straincarotovorum 2-40-08668-30Actinobacillus subsp.Chlamydophila carotovorumpleuropneumoniaeListeria felis strain monocytogenes strain PC1-30strain Fe/C-56-01 L20-30 strain 08-5578-08 0.021561 0.01626 0 1.13E-06 0 0.113459 0 0 0 0 0.016785 0 0.155556 0.003224 1.454909 0 5.53E-05 0 0 0.009239 0 0.002798 0.001841 0.523305 0 0 0 0 0.011957 0 0.058695 0 0.765971 0 0 0 0 0.019129 0 0.002218 0.005594 0.358059 0 0 0.001459 0 0.006961 0 0.028977 1.06E-05 1.022303 0.136265 0.002482 0 0 0.013538 0 0.038353 0.003226 0.462281 0.005072 0.000371 0 6.37E-19 0.016108 0 0.143345 0 1.353987 0 0 0 0 0.004215For Peer0 0.009894 0.005534Review0.267118 Only0 0 0 0 0.004326 0 0.059793 0.018954 1.080022 0 0 0 0.000667 0.008155 0 0.149531 0.003826 1.487621 0 0 6.70E-05 0 0.010976 0 0.021792 0.023422 1.059992 0 0 0 0 0.015597 0 0.066731 0.013305 1.550028 0 0 0 0 0.007664 0 0.02852 0.012107 0.089563 0 0 0 0.000554 0.013645 3.25E-17 0.005416 0 0.408217 0.0229 0 0 0 0.006292 0 0.007219 0.002505 0.297028 0 0 0 0.001513 0.018893 0 0.005416 0.001981 0.33142 0.017274 0 0 0 0.009598 0 0.000842 0 0.570087 0 0 0 0 0.00508 0 0.022605 0.001803 0.974337 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 268 of 848

SyntrophusMethylobacterium aciditrophicusArchaeoglobus strain sp. SB-01 MycobacteriumDM4-01 profundusLaribacter strain vanbaalenii DSM hongkongensisProchlorococcus 5631-08 strainGramella PYR-1-01 strain sp. MIT9211-08 forsetiiHLHK9-30Shewanella strainProchlorococcus sp.KT0803-30 MR-4-30 sp. AS9601-01 0.015971 0.002683 0.032716 0.002968 0 0.032513 0 0 4.90E-08 2.48E-08 0.000382 0 4.04E-08 2.13E-24 0.024193 1.155169 0.012263 0.000607 4.68E-05 0.001185 0 1.44E-06 0.005779 0.004681 3.720893 0 0.003394 0.00259 0.000825 0 1.11E-06 0.005025 0 1.9876 0.023006 0.000523 3.08E-07 0.001454 0 1.00E-04 0.006438 1.27E-06 1.791932 0 0.002203 0.001467 0.000869 0 0.000462 0.042745 0.007989 0.897326 0 0.002642 0.002993 0 0 4.28E-05 0.062433 0.009677 0.793986 0 0.002749 0.000139 0.001137 0 0.000212 0 0.017226 1.226628 0 0.01062 0.000171 0.001719For Peer0 0.000393 0.056717Review0.014583 1.178363 Only 0 0.000237 7.71E-05 0.000503 0 1.81E-05 0 0.001719 3.416079 0 0.003727 0.000956 0.002092 0 0.000152 0 0.005826 1.357545 0.087837 0.003944 0.001459 0.001483 0 0.00028 0.024537 0.015554 2.042337 0.08564 0.002063 4.49E-09 0.001104 0 0.000159 0.004366 0.002793 4.228207 0.015392 0.006619 3.91E-05 0.002243 0.000274 0.000207 0.017151 0.033086 0.799235 0 0.001787 0.001592 0.002955 0.007263 0.00025 0.020366 0 0.811445 0.012648 0.013265 5.69E-05 0.001609 0.000461 9.81E-05 0.000787 0.045785 0.995628 0.017638 0.003522 0.005236 0.001344 0.00932 0.000565 0.022804 1.84E-08 0.740484 0 0.005525 0.000674 0.000533 0 0.000318 4.71E-06 0.006493 1.020487 0.035629 0.001348 1.08E-05 0.001011 0 3.04E-05 0.028741 0.011114 2.816521 0 0.00434

Wiley-Blackwell and Society for Applied Microbiology Page 269 of 848

Chlamydia trachomatisStreptomycesThermoplasma strain griseus D/UW-3/CX-08 subsp.gamma acidophilum griseus proteobacteriumActinobacillus strain strain NBRCNeisseria DSM MLHE-1-30 pleuropneumoniae13350-30 1728-08 gonorrhoeaePedobacter Desulfotomaculum serovarstrainheparinus NCCP11945-08 3 str. strainMannheimia JL03-01 DSM acetoxidans 2366-30 succiniciproducens strain DSM 771-08str. MBEL55E-08 0 0.005465 0.000692 0.104991 0 0 0.256287 0.012894 0 0 0 0 0.000311 0 0.004347 0.100246 0.003263 0 0 0 0 0.043809 0.000686 0.002572 0.19453 0.00211 0.004144 0 0.000128 0 0.044483 0 0.014813 0.12045 0.001217 0.050271 0 0.000115 0 0.055372 0 0.0069 0.168027 1.29E-05 0.007623 0 0 0 0.04022 0.00397 0 0.003574 3.60E-17 0.078648 0 0.005574 0 0.038882 0 0 0.53327 0.002974 0 0 0.004379 0 0.143494 0.000826 0 0.095792 0.005352 0.114784 0 For0 Peer0 0.059583 Review0 0.011395 0.094883 Only0.001869 0 0 0.000752 0 0.092712 0 0.0064 0.002153 0.004283 0.064122 6.80E-17 0 0 0.011069 0 0.007742 0.045712 0.000172 0.031846 0 0 0 0.041267 0.002212 0.008556 0.116414 1.56E-05 0 0 0 0 0.151866 0.003291 0.026224 0.219098 0.003064 0.065326 0 0 0.003897 0.008985 0 0.002095 0.073671 0.000712 0.009829 3.05E-09 0.011209 0 0.317514 0.004844 0 0.292056 0.003441 0 0 0.000335 0.007107 0.027622 0 0 0.104259 0.00218 0.006662 0 0.004066 0.006881 0.063781 0.004031 0.016864 0.246145 0.005578 0.007163 0 5.21E-06 0 0.070115 0 0.005107 0.002688 0.00176 0 3.52E-06 6.09E-12 0 0.098735 0.003635 0.018894 0.087195 0.001992 0.056761

Wiley-Blackwell and Society for Applied Microbiology Page 270 of 848

SulfurovumHalorhabdus sp. NBC37-1-08Enterobacter utahensisBacillus strain sp. 638-30 DSM haloduransBurkholderia 12940-01 strainPseudomonas cepacia C-125-08 str.Capnocytophaga J2315-30putida strainSulfolobus W619-08 ochracea tokodaiiMycoplasma strain strain DSM penetrans 7-08 7271-01 strain HF-2-01 0.000108 0.000285 0 0 1.90E-05 0.031275 0.038928 0 0 0.005726 0 0 0.008293 0.013276 0.129828 0.080053 0 0 0.012902 0 0.00864 0 0.000775 0.024484 0.106076 0 0 0.005892 0 0 0.003246 0.004761 0.053734 0.23769 0 0 0.018483 0 0.003268 9.03E-07 0.00721 0.018232 0.115924 0 0 0.011647 0 0.024786 0 0.038756 0.097737 0.270937 0 0 0.006359 1.19E-06 1.99E-06 0.009676 0.004073 0.031774 0.130902 0 3.43E-13 0.018972 0.000271 0 0 0.007335 0.150241 0.331015 0 0 0.012691 For0 0.010467 Peer0.006595 0.001633Review0.022636 0.085957 Only 0 0 0.002912 0 0 0.002342 0.00014 0.0979 0.185512 0 3.44E-05 0.003038 0.000883 0.015255 0.002206 0.002219 0.126285 0.208979 0 0 0 0 0 0 0.001184 0.057508 0.169702 0 0 0.008115 0 0.000651 0.003716 0.00247 0.16343 0.423503 0 6.06E-05 0 7.28E-05 0 0 0.001859 0.007095 0.14741 0 0 0.092005 1.21E-06 0 0.011512 0.0069 0.057279 0.104861 5.59E-06 0.00015 0.000432 0 0.007919 0.0001 0.001582 0.021872 0.060546 0 0 0.011229 0 0.002742 0.00312 0.005786 0.033063 0.125117 5.76E-08 0 0.000583 0 0 2.80E-05 0.000595 0.032152 0.088993 0 0 0.007034 0 0.000228 0.000131 0.00293 0.114628 0.356749 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 271 of 848

Hahella chejuensisCaulobacter strainListeria crescentus KCTC innocua 2396-08Methylobacterium strain strain NA1000-08 PseudomonasClip11262-08 nodulansMycoplasma aeruginosa strainSinorhizobium ORS mycoides str. 2060-08 PAO1-08Natronomonas subsp. medicae mycoidesShewanella WSM419-08 pharaonis SC strain sp. strain PV-4-08PG1-01 DSM 2160-30 0.105189 0.08908 0 0.032783 0.028198 0 0.048574 0 0.040271 0.457505 0.032958 0 0.031267 0.105522 1.28E-09 0.032402 0 0.086219 0.14581 0 0 0.010217 0.034709 8.86E-08 0.016282 0 0.01931 0.298306 0.009646 0 0.012409 0.071463 0 0.029596 0.048462 0.058288 0.108736 0 0 0.010767 0.022777 0 0.019729 0 0.020266 0.449252 0 0 0.014046 0.109262 1.24E-05 0.021863 0.136377 0.072798 0.170141 0 0 0.012642 0.039334 0 0.025629 0 0.021186 0.503907 0 0.003339 0.01652 0.104008 6.01E-07 0.036197 0.179396 0.101323 0.113103 0.016841For0.001354 Peer0.003174 0.037366Review0 0.014428 Only 0 0.012487 0.403201 0 0.000902 0.008814 0.092744 6.03E-08 0.015041 0 0.05437 0.457159 0.028097 0 0.020105 0.132831 4.38E-08 0.017295 0.079947 0.066889 0.350245 0.052777 0 0.002286 0.075786 0 0.021371 0 0.035092 0.538785 0.039615 0 0.016214 0.172121 0 0.037055 0.036287 0.112144 0.035186 0 0 0.002547 0.009019 0 0.008314 0 0.008467 0.222353 0.046816 0.000232 0.020362 0.052452 1.52E-07 0.022622 0.005493 0.049633 0.148864 0.011312 0.000943 0.008591 0.029408 0 0.010803 0.026139 0.019428 0.154167 0.020913 0.00026 0.013134 0.037321 0.002737 0.019667 0.000391 0.032929 0.179803 0.01661 0 0.010741 0.035005 2.16E-11 0.016948 0 0.026293 0.421132 0 0 0.016862 0.139155 0.00071 0.026717 0 0.076077

Wiley-Blackwell and Society for Applied Microbiology Page 272 of 848

EnterococcusShewanella faecalis str.Helicobacter halifaxensis V583-08Lactobacillus strainpylori HAW-EB4-08strainShewanella delbrueckii 26695-30Methanosarcina sp. subsp. W3-18-1-08 bulgaricusSanguibacter mazei strainMethanococcus strain keddieii ATCC Go1-30 BAA-365-08 strainStreptococcus jannaschii DSM 10542-08 pyogenes DSM 2661-30 str. SSI-1-08 0.001559 0.014368 0.018264 0 0 0.111595 0.003398 0 0 0 0.073195 0 0 0 0.093516 0 0 0 0 0.013301 0 0 0.007164 0 0.001866 0 0 0 0.043289 0 0 0.017996 0 4.98E-07 0 0 0 0.016558 0 0 0.030838 0.01187 0.002611 0 0 0.000292 0.056438 0 0 0 0.183094 0 0 0 0.000507 0.023821 0.004141 0 0.047383 0.022576 0 0 0 0 0 0 0 0 0.240864 0 0 0 0 0.007367For Peer0 0 0.033285Review0.000687 9.76E-08 Only 0 0 0 0.047944 0 0 0.022048 0.033822 0 0.04445 0 0 0.071848 0 0 0.022509 0.190482 0.002395 0 0 0 0 0 0 0.082596 0.034439 5.02E-05 0 0 0 0.109477 0 0 0.049691 0.00138 0.004282 0 0.001724 0 0 0 0 0 0.023661 8.91E-07 0 0 0 0.040198 0 0 0 0.027676 0.003468 0 0 0 0.011483 0 0.000552 0.029814 0.012222 0.000396 0 0 0.004112 0.028319 0 0 0.018267 0.013805 0.001015 0.009074 0 0 0.023607 0 0 0.043326 3.90E-06 0.000323 0 0 0 0.060245 0 0 0 0.015145 7.39E-05 0.047927 0

Wiley-Blackwell and Society for Applied Microbiology Page 273 of 848

AnaerocellumProteus thermophilum mirabilisMethylobacterium strain strainMethanopyrus HI4320-08 DSM 6725-08 sp. Rhizobium4-46-08 kandleri sp.Geodermatophilus str. NGR234-08 AV19-08Magnetococcus obscurusLegionella sp. strain MC-1-30 pneumophilaJonesia DSM 43160-08 denitrificans str. Paris-08 strain DSM 20603-08 0.01429 0.061166 0.039166 0 0.048149 0.014827 0.127325 0 3.40E-05 0 0.018198 0.012798 0 0.046886 0 2.98E-05 0.015953 0.003471 0 0.00507 0.008709 0 0.02846 0.007119 0.021221 0 0 0 0.043582 0.012959 0 0.030052 0.000278 0.097917 0.023724 0.00779 0 0.035173 0.012573 0 0.025898 0.001206 0.019492 0.005599 0.003351 0 0.055893 0.00883 0 0.022158 0.000106 0.019005 0 4.39E-07 0 0 0.010891 2.80E-18 0.040554 0.006498 0.040655 0.02592 0 0 0.02992 0.026694 0 0.027661 1.01E-05 0 0.014324 0.011119 0 0.016529For0.00374 Peer0 0.018152Review0.002409 0.018822 Only0.017404 1.48E-08 0 0.021211 0.011195 0 0.030586 0.004097 0.026091 0 0 0 0.042766 0.008125 0 0.02073 0.002106 0.027533 0 0 0 0.045976 0.008094 0 0.017362 0 0.048559 0 5.77E-09 0.000727 0.04915 0.009712 0 0.039905 0 0 0.032865 0.005122 0 0.012141 0.00111 0 0.009392 0.002705 0 0 0 0.020004 0.052177 0.022728 0 0.031282 0.011578 0.085929 0.016926 0.001459 0.004027 0.008486 0.007304 0.000436 0.015268 0.001649 0.007914 0.006843 0.008397 0 0.024316 0.019265 2.61E-06 0.031613 0.008535 0.061249 0.021262 0.000898 0 0.025279 0.009582 0 0.022061 1.33E-06 0.031159 0.004306 9.11E-07 0.000235 0.026519 0.009592 0 0.028203 0.00281 0.002648 0.015299 0

Wiley-Blackwell and Society for Applied Microbiology Page 274 of 848

XanthomonasRalstonia oryzae solanacearumpv.Prosthecochloris oryzae strainMycobacterium strain MAFF aestuarii IPO1609-08 311018-30Roseobacter strain leprae DSMPectobacterium strain sp. 271-30 OCh114-08 Br4923-01Helicobacter wasabiaeBurkholderia pylori strain strain WPP163-30Anaeromyxobacter mallei HPAG1-01 strain NCTC sp. 10247-30 Fw109-5-08 0 0.008015 0 0 0.666163 0 0 0.02883 0.024507 0 0.00292 0.158677 0 3.572374 0 0 0.069992 0 0.000488 0.00443 0.033264 0 4.871649 0.005606 0 0.00049 3.37E-05 0.036288 0.001076 0.010988 0 6.318068 0.018559 0 0.035635 3.55E-05 0.004054 0.000924 0.002292 6.69E-08 4.535916 0 0 0.012724 4.12E-05 0.002644 0.005153 0 0 5.021658 9.81E-06 0 0 0.001099 0.009607 0.002997 0.116211 0 1.48766 0 0 0.017774 0.005886 0 0.003885 0 0 3.256916 0 1.49E-12 0.206892 0.003142 0.005694 0.001548For0.029462 Peer3.20E-05 1.542963Review0.009111 Only0 0.003245 0.002342 0.001969 0.003555 0 0 2.636861 0.032393 0 0.015828 0.003152 0 0.005067 0.24887 4.52E-06 2.681089 0.003528 0 0.067724 0.000606 4.51E-10 0.000629 0.00623 0 4.675943 0 0 0.028863 0.004677 0.003762 0.007284 0.068535 0 5.119412 0.002011 0 0.003497 0.002601 0.001581 0.001218 0.006466 0 0.592848 0.00967 0 0.011468 0 0.014816 0.007073 0.049214 0.001317 1.852672 0 0 0.016385 0.009876 0.000898 0.001762 0.023962 0 1.373218 0 0 0.006196 0.000114 0.005566 0.00716 0.026718 0 1.166158 0.015703 0 0.003406 0.007084 0.008991 0.002753 0 0 4.520532 0 0 0.017208 0 0.002598 0.006916 0.00122 0 5.326505 0.014131 0 0.001266 0.000373

Wiley-Blackwell and Society for Applied Microbiology Page 275 of 848

ChloroflexusVibrio sp. Y-400-fl-08 parahaemolyticusHalothiobacillusBurkholderia str. neapolitanus RIMDBurkholderia 2210633-08 cepacia strain AMMD-30Ralstonia malleic2-08 str. solanacearumDesulfovibrio ATCC 23344-30Streptococcus strain desulfuricans GMI1000-01Geobacillus gordonii subsp. kaustophilusstr.desulfuricans Challis substr. HTA426-01 strain V288-08 G20-08 0 0.017314 0.074379 0.001515 0 0.001029 0.008099 0.007368 0.004304 0 0.076155 0.038337 0.003849 0.070089 0.001011 0.002057 0 0.000649 0 0.018133 0.029492 0.000313 0.000844 0.000968 0.000626 0.00261 0.00196 2.54E-15 0.027772 0.074582 0.032372 0.009999 0.005209 2.85E-06 0 0 0.001261 0.011018 0.031664 0.004332 0.00336 0.00174 0.004028 0 2.10E-05 0 0.055521 0.114476 0 0 0.001217 0.003109 0 0.000565 0.008942 0.021274 0.076887 0.013483 0.034909 0.002721 0.002786 0 0.001186 0 0.043665 0 0.01222 0.168081 0.00292 0.003027 0 0.002254 0.000824 0.009017For0.038882 Peer0.00051 0.000546Review0.000639 0.001226 Only 0 0.000776 0.001522 0.057008 0.076524 0.008435 0.03851 0.001366 0.005765 0 0.00048 0 0.072546 0.079915 0.029199 0.112925 0.001081 0.004051 0 0.001676 0.010262 0 0.043842 0.000715 0.015611 0.000651 1.53E-05 0 0.000275 0 0.088557 0.147917 0.02121 0.030679 0.002344 5.13E-07 0 0.000261 0 0 0.017454 0.001419 0.001572 0.000778 0.001856 0 0.000163 0.010528 0.025809 0.068949 0.015791 0.00436 0.001464 0.001082 0 0 0 0.017199 0.027291 0.009626 0.009915 0.000914 0.000415 0 0.000467 0.012317 0.01752 0.036593 0.002514 0.000449 0.003353 0.00162 2.33E-14 0.001774 3.32E-11 0.005787 0.040088 4.18E-07 0 0.000117 0.002849 0 0 0.000547 0.08141 0.121566 0.002935 0.020679 0.001116 0.004138 0 0.000965

Wiley-Blackwell and Society for Applied Microbiology Page 276 of 848

Escherichia Synechococcuscoli O127:H6Sodalis strain sp. glossinidiusCC9902-01 E2348/69-01Sulfolobus Dale tokodaiiDelftia and Maudlin acidovorans strainStreptococcus 7-01 1999-01 strainNeisseria thermophilusSPH-1-08 meningitidisPseudomonas strain Leptospirastrain CNRZ1066-30 syringae alpha14-01 biflexa pv. phaseolicola serovar Patoc strain strain 1448A-30 Paris-30 0 0.00502 0 1.95E-15 0.018887 0 0.000105 0.010899 0.031516 0 0.00049 0 0 0.015896 0 0 0.015092 0 0 0.001578 0 0 0.012272 0 0.000998 0.008495 0 0 0.003843 0 0 0.00389 0 0 0.114952 0 0 0.000769 0 1.89E-06 0.006315 0 0.002429 0.027152 2.17E-05 7.02E-05 0.00029 0 0 0.016655 0 0 0.04095 0.01117 0 0.000224 0 7.27E-20 0.006521 0 0 0.04204 0 0 0.000246 0 8.57E-11 0.011686 0 0.005281 0.026503 0 0 0.021594For Peer0 0 0.003612Review0 Only0 0.018682 0 0.000206 0.000927 0 0 0.004477 0 0 0.061997 0 0 0.000393 0 0 0.013948 0 0 0.065915 0 0 4.05E-05 0 0 0.000515 0 0.003964 0.021227 0 0 0.000761 0 0 0.010477 0 0 0.048071 0 3.98E-11 0.385441 0 0 0.000501 0 0 0.001134 0.000205 2.41E-09 0.000812 0 4.76E-11 0.009649 0 0.004198 0.026281 0 0 0.238947 0 0 0.002312 0 0.003121 0.024874 0.010867 0 0.002707 0 8.12E-10 0.013673 0.014229 0.002379 0.01495 0.012119 0 0.000292 0.008289 0 0.005228 0 0 0.024529 0 0 1.84E-05 0 0 0.006357 0 0 0.038427 0

Wiley-Blackwell and Society for Applied Microbiology Page 277 of 848

PseudomonasBurkholderia multivorans-01Rhodothermus pseudomalleiNeisseria marinus strain meningitidis 1710b-30Proteus strain DSMmirabilis Prochlorococcusserogroup 4252-30 strain ABifidobacterium HI4320-30strain marinus Z2491-08Streptococcus str. longum MIT Legionella9515-08 str. mitis NCC2705-08 strain longbeachae B6-30 strain NSW150-01 0 0.030737 0.132326 0.004026 0 0.00715 0 0.521811 0.014116 0 0.079257 0 0.019146 0 0.001546 0 1.106818 0.001503 0 0.011264 0.017133 0 0.020758 0.017208 0 0 0.001627 0 0.003448 0.039346 0 0.217549 0.004696 4.13E-05 0 0.015664 0 0.006927 0.00117 0.006996 0.01284 0.003122 0 0.057176 0.006944 0 0.000153 0 0 0 0.007229 0 0.162598 0.005606 0 0.013517 0.059126 0 0.058221 0.000971 0 0 0.009888 0.029988 0.096043 0 0 0 0.03818 0 0 0.012558 0 0.000544For0.005346 Peer0 0.066203Review0 Only0 0.003684 0.006533 0 0.007322 0.019812 0 0.058224 0.004763 0 0 0.004569 0 0.052042 0.037512 0 0.118942 0.007806 0 0.440745 0.008343 0 0.002492 0.013506 0 0.296 0 0 0 0.008485 0 0.005456 0.0096 0.032422 0.018438 0.006172 0 0.185923 0.011386 0 2.91E-06 0.016386 0 0.001143 0.026385 0 0.179244 0.005913 0 0.004237 0.120535 0 0.015896 0.000561 0 0.105586 0.006701 0 0.000182 0.030997 0.00607 0.081559 0.152091 0 0.060966 0.004221 0 0.003467 0.100443 0 0.020259 0.002037 0 0 0.01366 0 0.001919 0 0 0.112401 0.000411 0 0.183616 0.000459 0 0.000846 0.014819 0 0.057157 0.006713 0 0.149761 0.011571

Wiley-Blackwell and Society for Applied Microbiology Page 278 of 848

Francisella tularensisDechloromonas subsp.Salmonella sp. tularensis RCB-30 Streptococcusenterica strain subsp. WY96-3418-08Vibrio mitis enterica fischeri strainBacillus serovar strain B6-01 cereus ES114-30 AgonaXanthomonas strain str. SL483-30G9842-01Methylococcus oryzae pv.Synechococcus oryzae capsulatus strain str.sp. MAFF OS-typeBath-08 311018-08 A strain JA-3-3Ab-01 0 0.154503 0 0 0.088678 2.84E-05 0.012203 0.285008 0.003227 0 0.090942 0 0 0 2.44E-07 0.004181 0.141734 0.003649 0 0.00573 0 0.001058 0.107125 5.18E-12 0.001482 0.064096 0.003578 0 0.000484 0.001394 0 0.113837 0 0 0.063002 0 0 0.014792 0 0 0.034924 5.02E-05 0.002312 0.054642 2.91E-05 0 0.07665 0 0 0.045136 8.24E-11 0 0.143434 0.001631 0 0.022543 0 0 0.026285 0.000113 0.007503 0.12222 6.01E-05 0 0 0 0 0 0 0 0.209544 0.001823 0 0.041845For Peer0 0 0.076308Review5.10E-05 4.27E-05 Only0.032451 0 0.059287 1.12E-06 0 0 0.066968 1.96E-05 0.003463 0.134636 0.00172 0 3.60E-09 0 0 0 8.14E-05 0.0038 0.151292 0.002383 0 0.020186 0.005274 0 0.19153 0 0 0.062084 0 0 0.002991 0 0 0.157705 0.000134 0.013132 0.218001 4.39E-05 0 0.000248 0 0 0 0.000133 0.002006 0.027062 0.001916 0 0.049708 0.001948 0 0 0.000138 0 0.136882 0.000757 0 0.010696 0 0 0.022659 5.39E-05 0.001585 0.050357 0 0 0.032722 0 0 0.028872 2.97E-05 0 0.106158 0.001213 0 0.086959 0 0 0.008041 6.76E-05 0.001588 0.037957 0.000567 0.027981 0.001116 0 0 0.014207 0.000104 0.009198 0.116688 0

Wiley-Blackwell and Society for Applied Microbiology Page 279 of 848

Escherichia Escherichiacoli strain BL21(DE3)-08 Streptococcuscoli strain BL21(DE3)-01Bacillus suis strainamyloliquefaciensEscherichia 05ZYH33-30 Cellvibriocoli strainstr. B japonicus substr.FZB42-01Saccharopolyspora REL606-01 strainAgrobacterium Ueda107-01 erythraeaStreptococcus vitis strain strain NRRL pyogenes S4-01 2338-08 strain SF370-08 0 0 0 0.000303 0.000549 0.052069 0.007662 0.01208 0.000258 0 0 0 0 0 0.026457 3.43E-05 0.00291 0 0 0 0.142497 2.16E-05 0 0.059968 0.003365 0.004847 0 0 0 0 0 0 0.129861 4.21E-14 0.012888 0 0 0 0 0.000655 0 0.056223 0.001712 0.006469 0 0 0 0 0 0 0.107118 0.002417 0.009288 0 0 8.16E-06 0 7.29E-05 0 0.112024 0.001879 0.013166 0 0 0 0 0.001728 0 0.095332 9.96E-05 0.009814 0 0 0.000324For Peer0 9.56E-10 Review0 0.054389 Only0 0.006553 0 0 0 0 2.57E-05 0 0.095427 0.000179 0.007305 0 0.011044 0 0.241376 0.000878 0 0.068312 0.001056 0.008031 0 0 0 0.000107 8.41E-06 0 0.124081 3.35E-06 0.007686 0 0 0 0 0.000143 0.000712 0.23795 0.005976 0.009687 0 0 0 0.000995 0.000573 0 0.029638 0 0.006698 0 0 0 0 0.001448 0 0.062425 0.006571 0.011694 0 0 0 0 4.35E-13 0 0.028764 0.001101 0.008828 0 0 0 0 0.000185 0.000255 0.088741 0.007193 0.011482 0 0 0 0 5.94E-10 0 0.017375 0.000271 0.002943 0 0.019152 0 0 3.07E-06 0 0.264903 0.000595 0.010287 0

Wiley-Blackwell and Society for Applied Microbiology Page 280 of 848

ArthrobacterMethanobrevibacter aurescensStreptococcus strain TC1-30 smithiiParabacteroides suis strain str. CampylobacterP1/7-30 ATCC distasonis 35061-01Acaryochloris hominisstrain ATCCCampylobacter strain marina 8503-30 ATCC MBIC11017-01bacterium BAA-381-30 jejuni subsp.EX-H1-01Pseudomonas jejuni strain entomophila NCTC 11168-08 strain L48-08 0 0.000123 0 0 0 0.004041 0 0 0.01575 0 0 0 0 0 0.001006 0 0.000752 0.093498 0.005049 0 0 0.065647 0 0.000508 0 1.13E-11 0.029455 4.04E-05 0 0.331896 0.028648 0 0.000389 0 0 0.055133 0.000933 0.000585 0 0.050575 0 0.000463 0 0.000384 0.018201 0 4.84E-05 0 0 0 0.003114 0 0.001476 0.107021 2.54E-08 3.43E-15 0 0.05261 0 0.002283 0 0.001747 0.03134 0 0.000605 0.384386 0.018068 0 0.003182 0 0.001911 0.120577 0.000607 For0 Peer0 0.008933 Review0 0.000785 3.10E-20 Only0.000217 0.014694 0 0 0 0.004191 0 0.001295 0 5.94E-05 0.088594 0 2.87E-12 0 0.032079 0 0.001145 7.17E-06 0.002503 0.111812 0 0 0 0.000881 0 0.001513 0 1.86E-08 0.050288 0 0 0 0.021107 0 0.001441 0.002708 4.60E-05 0.136268 0 5.89E-05 0.047674 0.029897 0 0.001082 0 0.000276 0.006398 0.000524 0.000341 0 0.119531 0 0.001374 0 1.41E-05 0.036462 0 0 0 0.015458 0 0.000274 0 9.98E-10 0.021992 0.002196 0.00179 0 0.076961 0.002512 0.001874 0 0.002597 0.030234 1.40E-05 1.36E-07 0 0.004238 0 0.000424 0.001405 7.12E-11 0.029165 1.55E-09 0 0 0.048642 0 0.000822 0 0 0.119965

Wiley-Blackwell and Society for Applied Microbiology Page 281 of 848

Ralstonia pickettiiSynechococcus strainSyntrophomonas 12D-30 sp. PCC6301-01Roseobacter wolfeiCloacamonas sp.subsp. OCh114-01 wolfeiNatranaerobius acidaminovorans-01 strain Goettingen-01Thiobacillus thermophilusLegionella denitrificans strain longbeachaemethanogenic JW/NM-WN-LF-30strain ATCC strain archaeon25259-01 NSW150-08 strain SANAE-30 1.66E-05 0 0.00865 0.085639 0.020093 0 0.014585 0.025788 0.07799 0.009245 0.009616 0.000619 0.073289 0.000352 0 0.004951 0.023998 0 1.89E-07 0 3.12E-06 0.135023 0 0 0.009587 0.032187 0 0.009754 0 0 1.08143 1.74E-08 0 0.015948 0.022637 0 0.013298 0 5.71E-05 0.390119 0.000921 0 0.009159 0.023606 0 0.002189 0 0 0.323191 6.48E-06 0 0.018837 0.038517 0 7.81E-05 0.002701 0.00092 0.216836 0.003728 0 0.029806 0.01314 0 0 0.002512 0.000815 0.261327 2.03E-05 0 0.019562 0.027926 0 0.00396 0.000145For0.000147 Peer0.327671 1.28E-05Review0 0.014181 Only0.013031 0 0.004225 0.007336 9.61E-06 0.288038 0.001661 0 0.01168 0.041232 0 0.003189 0.004466 0.000266 0.207154 0.000656 0 0.018007 0.034379 0 0.000262 0 0.000316 0.554299 0 0 0.009574 0.037521 0 0.000266 0.000506 0.000642 0.867762 0.001822 0 0.029369 0.057621 0 0.004183 0.005091 0 0.248023 0.001287 0 0.00957 0.007306 0 0.024099 0.001429 0.001257 0.150927 0.001916 2.75E-16 0.023666 0.04341 0.005208 0.012618 0 2.75E-12 0.219802 0 0 0.008647 0.012126 0 0.006902 0 0.001404 0.141189 0.003471 0.015192 0.033215 0.024794 0.008946 0 0.001667 4.87E-10 0.236976 5.40E-05 1.68E-08 0.006026 0.019633 0 0.006455 0 1.41E-10 0.920829 3.88E-05 0 0.021942 0.03451 0.008329

Wiley-Blackwell and Society for Applied Microbiology Page 282 of 848

MycobacteriumShewanella sp. JLS-30Synechococcus sp. MR-1-30Chromobacterium sp. RCC307-01Yersinia violaceum pestisExiguobacterium strain str. Angola-30 ATCCBrachybacterium 12472-08 sp. AT1b-01Desulfovibrio faeciumPaenibacillus vulgaris strain DSM strain sp. 4810-08 JDR-2-01'Miyazaki F'-08 2.50E-14 0.019107 0.000303 0.020146 0 0.004968 7.15E-05 0.017412 0.003012 0.063151 0.009323 0.012077 0.033356 0 0.001076 0.005052 1.63E-08 7.87E-08 2.58E-05 0.051633 0.003017 0.005756 0.008272 5.34E-06 4.98E-05 3.74E-07 0.001434 0.101133 0.02836 0.000196 0.024198 0 2.40E-23 0 0.000285 0.003292 0.003852 0.022302 0.000784 0.004913 0 0 0 0.000735 0.001197 5.27E-06 0.008182 0.003619 0.031886 0.08071 8.59E-05 0 0.002103 0.001591 0.003541 0.003208 0.002395 0.015364 0 0.000459 4.52E-06 0.00873 0.002002 0.005321 0.043138 0.003201 0.023368 0.078115 8.27E-15 0 0 0.002666 0.003225 0.028671For0.00219 Peer0.010105 Review0 0.000276 1.91E-08 Only0.00083 0.00116 0.02011 0.045302 0.003085 0.022441 0.026272 0.000132 2.19E-10 0.002451 0.000972 0.086191 0.100553 0.001919 0.025929 0.0241 0.002393 0 0.002087 0.001035 0 0.062483 0.000242 0.019074 0 1.36E-24 0 0 0.001469 0.032817 0.011154 0.000903 0.043904 9.29E-05 0 0.005405 0.000387 0.003049 0.009527 0.007918 0.011052 0.000866 0 0.000471 2.05E-10 0.000107 0.000452 0.012217 0.014038 0.001781 0.004708 0 0.001508 1.09E-15 0.00288 0.001384 0.01233 0.040054 0.004824 0.007833 0 0.001512 0 0 0.001108 0.005379 0.006672 0.000881 0.012827 4.70E-12 0.000939 0.007937 0.003761 0.002064 0.024313 0.076136 5.93E-05 0.00269 0 5.80E-05 0.000263 0.002591 0.000216 0 0.018412 1.29E-05 0.038039 0.003632 4.82E-09 0.000144 0.002688 0.00245

Wiley-Blackwell and Society for Applied Microbiology Page 283 of 848

AcidiphilumStreptococcus cryptum JF-5-30Clostridium pyogenesStreptococcus botulinum strain Manfredo-01 ClostridiumA strain zooepidemicus-08 ATCCShigella difficile 19397-01 dysenteriaestrainPseudomonas CD196-08 strainBordetella syringae Sd197-30 pertussisEscherichia pv. phaseolicola Tohama coli strain strainI-01 APEC 1448A-08 O1-08 0.015566 0 6.33E-07 0 0.034748 0 0 0.002989 0 0.001421 0 2.73E-05 0 0 0 0.077131 1.22E-06 0 0.019279 0 1.33E-08 0 0 0.00407 0.024163 0.001736 0 0.003317 0 0 0 0 0 0.045348 0.001866 0.001345 0.009383 0 0.000708 0 0 0 0.019355 0.00184 0 0.003408 0 0 0 0 0 0.101533 0.001995 0 0.02299 3.37E-05 0 0 0 0 0.020246 0.003137 0 1.38E-08 0 0 0 0.009437 0.108156 0 0.001924 0 0.001928 For0 2.73E-05 Peer0 0.002059Review0.004428 0.017702 Only0.003098 0 0.001529 0 0 0 0 0 0.067145 0.000951 0.000396 1.14E-12 0 0.000166 0.003476 0 0 0.085656 0.00183 0 0.004566 0 0 0 0.005412 0 0.044163 0.00137 0 0.005006 0 0 0.011764 0 0 0.103976 0.003925 0 0.00767 0 0 0 0 0 0.00527 0.003314 0 0.024227 0 0 0 0 0 0.032337 0.003607 0 0.007424 0 1.09E-06 0.003659 0 0.007945 0.01333 0.001178 0 0.013591 0 7.93E-05 0.000854 0 0 0.026153 0.002163 0 0.028972 0 0 0 0 0 0.02885 0.000545 1.16E-08 0.007943 0 0.000799 0 0 0 0.090162 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 284 of 848

Prevotella ruminicolaEscherichia strain Bartonellacoli O55:H7 23-30 grahamiiSaccharopolyspora strain CB9615-30 strainLactobacillus as4aup-01 erythraeaGeobacter crispatus strain metallireducens Listeriastrain NRRL ST1-30 monocytogenes2338-30Lactobacillus strain ShewanellaGS-15-01 strainplantarum 08-5923-30 baltica strain strainWCFS1-30 OS195-08 0.064966 0.021551 0 0.000553 0 0.039869 0 0 0.006181 0.000592 0 0.000335 0 0 2.07E-05 0 0 0 0.019962 0 0.001168 0 0 0.000175 0 0 0.005453 0.037189 0 0.001062 0 0 0.000676 0 0 0.014583 0 0 0.004402 0 0 0.002077 0 0 0.00373 0.008747 0 0.002302 0 0 0.001062 0 0 0.023653 0 0 0 0 0 0.004597 0 0 0 0 0 0 0 0 0.001772 0 0 0.02059 0.006272 For0 0.002845 Peer2.13E-09 Review0 0.001702 Only0 0 0.010861 0.034018 0 0.00164 0 0 0.000795 0 0 0.013927 2.01E-05 0 0.004727 0 0 0.00179 0 0 0.01606 3.05E-10 0 0.002186 9.41E-07 0 0.0014 0 0 0.029112 0.001877 0.003364 0 0 0 0.001571 0 0 0 9.54E-07 0.010178 0.007614 0 0 0.000331 0.018504 0.00014 0 0.067658 0 0.004441 0.020238 0 0.004648 0 0 0 0.009705 0 0.003284 0.00017 0 0.000631 0 0 0.002616 0.030578 0 0.003796 0.002527 1.97E-07 0.006172 0 1.25E-08 0 0.040632 0 0.00043 0 0 0.000234 0 0 0.0107 0.000906 0.008692 0.003013 0 0 0.00071 0 5.76E-06 0.022317

Wiley-Blackwell and Society for Applied Microbiology Page 285 of 848

BurkholderiaGeobacillus mallei strainXanthomonas sp. 10229-30Y412MC61-01Sphingopyxis axonopodisShewanella alaskensis pv. citriDehalococcoides pealeanastr. strain 306-08 RB2256-08 strainMycobacterium ATCC sp. GT-08 700345-30Methanoculleus vanbaaleniiRhodobacter marisnigristrain PYR-1-08 sphaeroides strain JR1-30 strain ATCC 17029-01 0.019688 0.003175 0.005832 0.195394 0.035236 0 0.004407 0.038221 0.013309 1.18E-07 0.000504 0.011705 0.055322 0 0 0 0 0.00331 0.000403 0.000713 0.001813 0.011554 0.009684 0.009489 0.001935 0 0.008388 0.011339 0.000308 0.007231 0.020122 0 0 0.000148 0 0.068169 0.007266 1.91E-05 0.005873 0.019423 0.018724 0 7.05E-05 0 0.028284 2.12E-06 0.000209 0.013607 0.012454 0.023158 0 0.002143 0 0.01808 0.011013 0.000799 0.005119 0.030254 0.048626 0 0.00021 0.000524 0.024056 0.242983 0.001215 0.00465 0.04364 0.125637 0 0.004755 0 0.022321 0.002277 0.001848For0.001965 Peer0.018633 0.050022Review0 0.000566 Only 0 0.025793 0.043686 0.000226 0.004428 0.01816 0.003058 0 0.000223 0 0.017336 0.078687 0.001022 0.006614 0.018927 0.045649 0 0 0 2.76E-10 0.016766 0.000328 0.003007 0.021618 0.057167 0 0 0 0.05113 0.011828 0 0.010592 0.051076 0.045424 0 0.000792 0 0 0.011091 6.88E-05 0.003682 0.00755 0.016553 0 2.20E-05 0.000959 0.024598 0.006186 0.005041 0.01992 0.040558 0.04317 0 0.000673 0.003204 1.40E-11 7.72E-05 0 0.001588 0.012298 0.04332 0 0 5.31E-05 0.019392 0.002336 0.001812 0.007952 0.033239 0.027545 0.009955 0.002832 0.01085 0.001647 0.026762 0.002261 0.001896 0.011394 0.04074 0 7.47E-07 0 0.000913 0.024479 0.000474 0.008868 0.015301 0 0 0.000579 0 0.071447

Wiley-Blackwell and Society for Applied Microbiology Page 286 of 848

XanthomonasBorrelia oryzae burgdorferi pv.Anaeromyxobacter oryzae strain strainMycobacterium ZS7-08 PXO99A-01 sp.Thermobifida Fw109-5-01 avium Borreliastr. fusca 104-08 turicataestrainRhodopseudomonas YX-08 strainMeiothermus 91E135-01 palustrisRhizobium ruber strain strain radiobacter BisA53-08 DSM 1279-30 str. C58 (U. Washington)-08 0.001294 0 0.002514 0.006927 0.03403 0 0.050104 0 0.065664 0.000283 0 1.25E-07 2.94E-06 0 0 0.004731 0 0.026321 0.000763 0 1.10E-05 0 0.001984 2.94E-11 0.015343 0 0.06074 0 0 1.66E-07 0.000496 0 0 0.005101 0 0.093934 0 0.002157 2.93E-05 0.000888 0.002888 0 0.006811 0 0.063622 0.001371 0 0.000654 0.000285 2.34E-06 1.70E-12 0.010251 0 0.076895 0 0 0.000537 0.001395 0.011348 0 0.010868 0.029857 0.044709 0 0 0.000932 0.004568 0 0 0.010801 0 0.051882 0 For0 1.82E-05 Peer0.000255 0.00052Review0 0.007375 Only 0 0.025607 0.000541 0 0.000154 0.00037 0.003917 0 0.006356 4.30E-05 0.054592 0.001146 0 0.000815 1.36E-06 0.005692 4.46E-09 0.005444 0 0.081578 0.000513 0 7.98E-05 0 0 0.000754 0.009596 0 0.06733 0 0 0.000619 0.001216 0.00199 0 0.012347 0.018848 0.113095 0.000773 0 0.000105 0 0 0.000209 0.002447 0 0.013386 0 0 0.003531 0.004533 0.00857 0.004691 0.012785 0.000146 0.014481 0 0 4.83E-05 0 0.000466 0.000726 0.007299 0.013635 0.022232 0.002533 0 0.002722 0.00069 0.009944 0 0.012796 0.033858 0.061631 0 0 3.52E-05 0 6.99E-14 0 0.003557 0.019652 0.054366 0 0 0.000123 0.000401 0.003621 9.60E-12 0.014388 0 0.108471

Wiley-Blackwell and Society for Applied Microbiology Page 287 of 848

ThiobacillusThermobifida denitrificansBacillus fuscastrain haloduransstrain ATCCMycoplasma YX-0125259-08 strainLeptospira conjunctivae C-125-01 biflexaTeredinibacter strain serovar HRC/581-30Syntrophomonas Patocturnerae strainGemmatimonas strain Paris-01 wolfei T7901-08Staphylococcus subsp. aurantiaca wolfei strain saprophyticusstrain Goettingen-08 T-27-30 subsp. saprophyticus strain ATCC 15305-30 0.054005 0.013931 0.003366 0 0.003821 0.109419 0.021662 0 0 0.035165 0 4.74E-05 0 0.000877 1.057579 0.007983 0 0 0.023091 0.000171 0.000564 0.079321 0.002253 0.479838 4.50E-22 0.000178 0 0.046568 0 0.00072 0 0 0.521767 0.00554 0.00221 0 0.017458 0.001403 0.000108 0.045099 0 0.249733 0.000336 0.003266 0 0.055215 0.000252 0.000471 0 6.67E-05 0.923231 0 0.002721 0 0.027919 0.001616 0.001804 0.109302 0 0.358707 0 0.02163 0 0.046493 0.003272 0.001726 1.631466 0.003191 1.216862 0 0.00471 0 0.023287 9.06E-05For4.61E-06 Peer0.078885 0.000711Review0.195065 Only0 0.010943 0 0.062258 0.00058 0.000889 0.145505 0.000769 0.952385 0.000268 0.026554 0 0.080019 0.000931 0.002114 1.21012 0 1.342308 6.91E-05 0.067419 0 0.024233 0.000897 0.001253 0.067633 0.000261 0.604834 0 0 0 0.089878 0.000765 0.000128 0.08486 0.003906 1.31369 0.002953 2.50E-05 0 0.019487 0.001515 0.000341 0.043387 1.23E-06 0.084177 0.000387 0.004049 0 0.090316 0.002726 0.001476 0.063025 0.002262 0.407998 0.008463 0.022457 0 0.00329 0.00063 0.000357 0.190934 0 0.216769 8.06E-07 0.000331 0 0.033433 0.001247 0.001611 0.027258 0.004309 0.27727 0.001193 0.030992 0.008948 0.009559 0.000682 0.000671 0 2.09E-05 0.450893 8.47E-06 0 0 0.082783 0.000276 0.00032 0.098545 0.000527 1.036594 0.000621 0.012264 0

Wiley-Blackwell and Society for Applied Microbiology Page 288 of 848

Rothia mucilaginosaPelodictyon strainFrancisella luteolum DY-18-01 DSMtularensisSynechococcus 273-01 subsp.Photorhabdus sp. tularensis WH7803-30Rhizobium luminescens strain leguminosarumFSC198-30Campylobacter subsp.Rickettsia laumondii fetusbv. trifolii subsp.peacockii bacteriumstr. strainTTO1-08 fetus strain WSM1325-08 2-40-30 strain Rustic-08 82-40-01 0.01196 0.020977 0 0 0.025547 0.011873 0.002287 0 0.260027 0 0.00018 0 0.213573 0.02546 0.010549 0.000974 0 1.003693 0 0.000743 0 0.011572 0.004417 0.006389 4.94E-11 0 0.476776 0 0.000367 0 0 0.024987 0.010235 8.59E-09 0 1.502612 0 0.000141 0 0.007894 0.011503 0.009077 0.001502 0 0.446522 0 0.001582 0 0.030638 0.028948 0.016325 2.03E-05 2.96E-15 1.184659 0 0.001396 0 0 0.003128 0.00858 2.17E-13 0 0.366891 0.001667 0.003011 0.021733 0.120115 0.017914 0.017722 2.61E-05 0 0.84158 0 0.000638For Peer0 0.058899 0.002125Review0.009308 0.001189 Only 0 0.492754 0 0.002281 0 0.025205 0.009386 0.010762 0 0 0.788395 0.000191 0.002722 0 0.009479 0.010679 0.014424 0.000427 0 1.182762 1.22E-05 0.000343 0 0.08675 0 0.017095 0.001141 0 0.948085 0 0.000636 0 0.06797 0.027213 0.015627 0.000154 0 0.499407 0 0.000323 0 0.352527 0.006529 0.003423 1.08E-22 0 0.333635 1.02E-27 0.000657 0 0.023794 0.004901 0.009162 0.001402 0 0.48218 0 0.001117 0 0.19572 0.008222 0.003237 5.00E-23 0 0.559893 0.000772 0.004948 0 0.009745 0.007683 0.006093 0.000977 0 0.207372 0 9.04E-05 0 0 0.005792 0.005552 3.25E-06 0.000865 0.5265 0 0.000602 0 0.049472 0.012796 0.014119 0 0 0.766256

Wiley-Blackwell and Society for Applied Microbiology Page 289 of 848

ActinobacillusBacillus pleuropneumoniae anthracisErwinia strain pyrifoliae Roseiflexusserovar Ames-01 strain 7 strainClostridium castenholzii Ep1/96-08 AP76-01Clostridium botulinum strain DSM Xanthomonas Aperfringens 13941-08strain ATCCPseudomonas str. campestris3502-08 13-30Symbiobacterium fluorescenspv. campestris strain thermophilumstrain Pf-5-08 B100-01 strain IAM 14863-30 0.008461 0 0.005117 0.041053 0 0 0.001937 0.031648 0.064018 3.48E-07 0 0 0.020177 0 0 0.001328 0.080443 0 0 0 0.006266 0.000338 0 0 0.001093 0.016593 0 0.003734 0 0.009745 0.000672 0 0 0.000292 0.048046 0.037378 0.002763 0 0.005172 0.000141 0 0.007222 0.00111 0.01741 0.001476 0 0 0.017345 1.18E-05 0 0 0.000665 0.104295 0 0.0071 0 0.002642 0.004883 0 0 0.002836 0.041004 0 0 0 0 0.004948 0 0 0.00166 0.115524 0 0.001266 For0 0.005678 Peer0.004361 Review0 0 0.000722 Only0.018274 3.95E-17 0.002689 0 0.014899 0.001985 0 0 0.000427 0.077961 0 0.002222 0 0.016502 0.003351 0 0 0 0.107338 0 0.002167 0 0.039023 0.000361 0 0 0.000627 0.037044 0 0.006843 0 0.02681 0.00455 0 0 0.002492 0.145848 0 0.0025 0 0 0.001266 0 0 0.001192 0.003644 0 0 0 0 0.004257 0 0 0.00163 0.041756 0.032632 0.000301 0 0.003474 0.002822 0 3.01E-05 0 0.021045 0.020322 0 0 0.004427 0.008609 0.002163 0 0.002386 0.019355 0.015046 0 0 0.010754 0 0 0 0.000348 0.032612 0 0.006224 0.000195 0.019451 0.001833 0 0 0.000926 0.103835 0

Wiley-Blackwell and Society for Applied Microbiology Page 290 of 848

BifidobacteriumDesulfovibrio longumThermosynechococcus str.magneticus NCC2705-01Geobacillus strain RS-1-01Bifidobacterium elongatuskaustophilus strainHaloquadratum HTA426-08 lactisBP-1-08 AD011-30Shewanella walsbyiBuchnera sp. strain W3-18-1-30 DSM aphidicolaSalmonella 16790-08 str. enterica Cc (Cinara subsp. cedri)-08 enterica serovar Paratyphi B strain SPB7-08 0 0.004073 0.027881 0.036292 0 0.004941 0 0 0 0 7.56E-06 0.009077 0 0 0 0 0 0.005097 0 3.33E-07 0.076001 0 0 0 0.018917 0.004474 0.004931 0 0.001556 0.026279 0 0 0 0 1.09E-18 0 0 0.000274 0.017556 0.003813 0 0.005188 0.097411 9.48E-15 0 0 0.000201 0.02613 0.004093 0 0 0.191906 0 0 0 0.002069 0.029839 0.008346 0 0 0 0 0.005283 0 9.16E-05 0.067879 0.00073 0 0 0 0 0 0 1.70E-05For0.021395 Peer0.005489 Review0 0 0.149811 Only 0 0 0 6.99E-06 0.03036 0.002876 0 0 0.012565 0.00514 0.00676 0 0.0011 0.037379 0.000225 0 0 0.107033 0 0 0 4.42E-05 0.194554 2.15E-11 0 0 0 0 0 0 0.00083 0.021936 0.001303 0 0.004052 0 0 0 0 0.0003 0.084037 0.001514 0 0 0.049352 0 0 0 0.000842 0.002943 0.014383 0 0 0 0.032745 0 0.000285 4.55E-05 0.050892 0 0 3.65E-12 0.27852 0 0 0 0.001876 0.007842 0.013324 0 0 0.026768 0 0 1.91E-05 2.31E-05 0.023163 0 0 0 0.319646 0 0 0 4.48E-06 0.024052 0.003836 0.015351 0.001602 0.005986 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 291 of 848

Bacillus thuringiensisBacillus cereus serovarWautersia strain konkukian 03BB102-01 eutrophaRoseobacter strain JMP134-08Laribacter 97-27-01sp. OCh114-30 hongkongensisMycoplasmaBacillus crocodyli strain tusciae HLHK9-01 Methanosphaerastrain strain MP145-01 DSMHalorubrum 2912-30 stadtmanae lacusprofundi strain DSM strain 3091-08 ATCC 49239-30 0 0.000527 0.023763 0.485076 0.0017 0 0 0.000308 0 0 0.000697 0.013425 1.085973 0.005037 0 0 0 0 0 2.14E-05 0.011423 1.52278 0.004556 0 0.000656 0 0 0 2.00E-06 0.009794 6.496937 0.002846 0 0 0 0 0 0.000141 0.00176 3.662448 0.00332 0 0.001832 0 0 1.47E-05 3.32E-05 0.009677 2.767068 0.011865 0 0 0 0 6.99E-05 0.000159 0.012747 1.169787 0.010719 0 0 0 0 0 1.25E-05 0.021737 3.074759 0.01148 0 0 0 0 0 7.61E-05For0.00326 Peer1.210974 0.004433Review0 8.76E-12 Only 0 0 0 4.90E-05 0.017778 2.185946 0.005664 0 0 0 0 2.77E-05 0.00016 0.011937 2.260128 0.011216 2.12E-17 0 0 0 0 5.00E-05 4.33E-05 1.571276 0.008527 0 0 0 0 0 0.000198 0.021196 2.38432 0.015188 0 2.51E-16 0 0 0 0.000126 0.001973 0.40414 0.003539 0 0 0.012822 0 0 0.000218 0.010472 0.867985 0.013292 1.72E-18 0.000216 0 0 0 0.000171 0.004613 1.157815 0.001643 0 0.002697 0 0 0.000115 0.000177 0.01336 0.684536 0.013686 0 0.019384 1.52E-05 0 0 0.000417 0.007823 3.199809 0.003335 0 0 0 0 3.04E-05 0.000188 0.019148 1.946121 0.011078 0 0 0 0.022583

Wiley-Blackwell and Society for Applied Microbiology Page 292 of 848

StaphylococcusFrancisella lugdunensis tularensisMacrococcus strain subsp.Neisseria HKU09-01-30 caseolyticus holarctica meningitidisVariovorax strain strain JCSC5402-08 VibrioFTNF002-00-30strainparadoxus FAM18-08cholerae strainDictyoglomus serotype S110-08Escherichia O1turgidum biotype Escherichiacoli strain ElTor strain DSM strain UTI89-01 coli 6724-30 N16961-30 strain APEC O1-01 0 0 0 0 0.02894 0 0 0 0 0 0 0 0 0.006862 0 0 0 0.000299 0 0 0 0.008397 0.009786 0 0 0 0 0 0 0 0 0.011468 0 0 0 2.15E-18 0 0.002575 0 0 0.006251 0 0 0 0 0 0 0.004316 0 0.01117 0 0 0 0 0 0 0 0 0.009962 4.10E-05 0 0 0.000521 0 0 0 0.023126 0.023794 0.1223 0 0 0 0 For0 0.00531 Peer0 0.003572Review0 Only0 0 2.17E-05 0 0 0 0 0.017104 0 0 0 0 0 0 0.000802 0 0.016215 0 0 0 1.90E-06 0 0 0 0 0.016533 0.067454 0 0 0 0.019322 0.002467 0 0 0.019142 0 0 0.000243 0 0 0 0 0.002175 0.000314 0 0 3.81E-11 0 0 0 8.13E-05 0 0.006711 0 0.055465 0 0 0 0 0 0.00226 0.001167 0 0 0 5.73E-06 0.001313 0 0.000692 0 0.017054 0 0.02858 0 0 0 0 0 0 0.004939 0 0 0 0 0 0.023698 0 0 0.028597 0.06702 0 0 9.98E-05

Wiley-Blackwell and Society for Applied Microbiology Page 293 of 848

MycobacteriumLeptospirillum tuberculosisEubacterium ferrooxidans strainBurkholderia H37Rv-30eligens ATCC strain Verminephrobacter53993-01 cepacia ATCC 27750-01str.Thermomonospora J2315-08 eiseniaeClostridiales strain curvataAlkaliphilus EF01-2-08genomosp. strain ShewanellaDSM metalliredigens BVAB3 43183-30 str. sp. UPII9-5-01 MR-1-01 strain QYMF-08 0 0 0.00245 0.003826 0.031432 0.081505 0.005464 0.020984 0.002592 0 0.002646 0 0.007923 0.026163 0 0 0.015752 0.000913 0 0 0 0.001926 0.011377 0.008824 0 0.00015 0.000691 0 0 1.35E-20 0.00646 0.012886 0.002321 0 5.91E-05 0.00178 0.000484 0 0.000476 0.004778 0.00753 6.29E-15 0.000252 0 0.001882 0 0.015913 0 0.007548 0.021074 0 0 0.00806 0.004795 0 0 0.000689 0.003386 0.0117 0.000634 0 0.007496 0.001232 0 0.016319 0.000448 0.011353 0.042974 0.080464 0 0.000625 0.00465 0 For0 Peer0 0.002814 0.001318Review4.31E-05 Only0 0.000778 0.001343 0 0 0.000502 0.006259 0.020783 2.55E-15 0 0.006688 0.001747 0 0 0.001612 0.010254 0.022693 0 0.000866 0.002534 0.003382 0 0.004598 9.16E-21 0.004074 9.48E-05 1.20E-08 1.56E-13 0 0.001972 0 0 0.000265 0.009727 0.032841 0 0 0.000533 0.005348 0.000158 0 0.000142 0.000503 0.000279 1.52E-08 0 0 0.001325 0.001975 0.017373 0.00069 0.005842 0.02054 0.012328 0.000148 0.007241 0.002354 0 0.001195 1.19E-06 0.003944 0.003785 0.001058 0 2.77E-05 0.00043 0 0 2.37E-05 0.006712 0.020051 0.01564 3.84E-09 0.010484 0.002402 0 0 1.40E-20 0.001677 0.01179 0.026078 0.000141 0.000233 0.000735 0 0 5.14E-05 0.011818 0.024982 0.00555 0 1.09E-06 0.005512

Wiley-Blackwell and Society for Applied Microbiology Page 294 of 848

DesulfovibrioBacillus vulgaris megaterium strainChlorobaculum 'Miyazaki strainThiomicrospira parvumQMF'-01 B1551-01Escherichia strain crunogena NCIB Bacilluscoli 8327-01 strainO111:H- amyloliquefaciens XCL-2-01Delftia strain acidovorans 11128-30Mimi-01 strain strain FZB42-08Thermus SPH-1-01 thermophilus HB8-30 0.001237 0.000873 0.041021 0.029925 0 0 0.002443 0 0 0.000904 2.03E-06 8.95E-05 0.020112 0 0.008895 0.000125 0 0 7.47E-05 0.000308 0.001753 0.034107 0 4.35E-05 0.000848 0 0 0 1.54E-05 1.80E-06 0.029078 0 0 0.001356 0 0 4.53E-05 0 0.000869 0.010263 0 0 0.001005 0 6.50E-05 8.64E-05 0.000267 0.003876 0.069657 0 0.002711 0.001729 0.002466 0 0.000814 0.000368 0.008009 0.077936 0 0 0.000828 0 0.021911 0.000241 3.96E-07 0.001806 0.08896 0 0 0.002566 0 0 8.91E-05 0.000186For0.003203 Peer0.015282 Review0 0 0.002558 Only 0 0.002433 9.65E-05 0.000264 0 0.055192 0 0 0.002063 0 0 0.000256 0.000147 0.003447 0.05033 0 0 0.001961 0.004054 0 6.56E-08 0.000173 0.000256 0.021231 0 0 0.001611 0 0 8.99E-05 0.000251 0.004409 0.08707 0 0 0.001884 0 0 0.000213 0.000148 0.002226 0.010833 0 0 0.000679 0 0 0.002675 0.00068 0.001597 0.093121 0.001542 0.002062 0.002824 0 0.00055 6.82E-05 6.10E-05 0.00196 0.008483 0 0.000375 0.000262 0 0 0.00148 0.000881 0.001405 0.083324 0 0.000708 0.002796 0.002807 0.006545 2.33E-08 9.19E-08 0.000673 0.008844 0 0 0.000259 0 0 0.000186 0.000332 0.001817 0.082607 0 0 0.002964 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 295 of 848

ClostridiumShigella botulinum flexneri RhodococcusF strain 5 strain Langeland-01Prochlorococcus 8401-08erythropolisXanthomonas strain marinus PR4-08Salmonella subsp.oryzae marinuspv. Fervidobacteriumenterica oryzae str. subsp. strain SS120-30Haemophilus entericaKACC10331-30 nodosumAcinetobacter serovarparasuis strain Newport strain Rt17-B1-08 baumannii SH0165-08 strain strainSL254-01 ACICU-01 0.000304 0 0.006081 0 0 0 3.82E-05 0.007705 0.00173 2.00E-05 0 0.00055 0.114107 0.000334 1.50E-07 0 0.058935 0.001223 1.23E-08 2.74E-06 0.001895 0 0.000487 0 0 0.012056 0.002995 3.86E-06 1.89E-06 0.004261 0 0 0 4.48E-09 0 0.003286 2.29E-05 0 0.004417 0.032304 0.003213 0 0 0 0.001807 0 0.000562 0.003554 0 0.002643 0.000887 0 0.043184 0.006794 3.16E-05 0 0.001107 0.042244 0.008019 0 0 0 0.005501 0 0 0.000526 0 0 0 0.001976 0 0.004975 2.53E-05 For0 8.05E-06 Peer0 0.004854Review0.00032 Only0 0.008407 0.001974 0 0 0.003411 0 0 0 0.004482 0 0 0.00019 0 0.000723 0.029788 0 0.000642 0 0.028913 0.003291 1.89E-05 0 0.00382 0 0 0 0 0.022631 0.004534 0.000124 0 0.006353 0.120712 0.00376 0 0.001358 0.08287 0.006374 5.25E-05 0 0 0.043828 0 0 0 0 0.004393 0.000551 0 0.000399 0.011697 0.012406 0.000649 0.007586 0 0.002624 8.62E-06 0 0.000112 0.01912 0.000898 0 0 0.009844 0.001745 7.35E-05 0 0.003486 0.007504 0 0 0.000421 0.004919 0.005861 8.11E-06 0 0.001515 0.07183 0.008987 0 0.000896 0.027759 0.000894 0 0 0.001409 0 0 0 0 0.054709 0.006809

Wiley-Blackwell and Society for Applied Microbiology Page 296 of 848

Legionella longbeachaeXanthomonasCitrobacter strain albilineans NSW150-30 Slackiakoseri var. strainheliotrinireducenspaspali-30Prochlorococcus ATCC BAA-895-01Thermoplasma strain sp. MIT9211-30 DSMNitrobacter 20476-01acidophilumCoxiella hamburgensis strain burnetiiMycobacterium DSM strain strain 1728-30 X14-08 CbuK_Q154-30 sp. MCS-01 0.014942 0.00042 0 0.001888 0 0 0.127252 0 0 0.000201 0 0.000111 0.000366 0.002968 0 0.00252 0 0 0.002692 2.03E-06 0 9.89E-18 0.002427 0 0.013124 0 0 0.065955 0.032306 0.000965 0 0.046227 0 0.016882 0.09059 0 0.025614 0.009891 0.001166 1.43E-07 0.030084 0 0.032284 0 0.000364 0.001475 0 0.00109 0.000164 0.267189 0 0.011 0.181146 0 0.026828 0.013228 0.001175 5.76E-06 0 0 0.023876 0 0 0.121117 0 0.000206 0.00036 0 0 0.026846 0 0 0.012053 0.000695For0.000782 Peer0 0.047853Review0 0.00752 Only 0 0.000375 0.001103 0 0.000947 6.13E-05 0 0 0.006809 0 0.000283 0.055878 0.071715 0.000164 1.70E-06 0.190093 0 0.00578 0 0 0.027661 0.021621 0.001862 7.87E-09 0.006197 0 0.048767 0.115754 0.000272 0.001593 0 0.002991 6.75E-06 0.084694 0.013575 0.009406 0 0 0.0053 0.017527 0 2.18E-06 0.059311 0 0.006099 0 0.000173 0.047676 0.041195 0.001646 0 0.064754 0 0.015291 0.179398 0.000246 0.013342 0.005401 0.000863 6.44E-05 0.039657 0 0.004573 0 0.000779 0.018648 0.011072 0.001295 0.000815 0.00802 0.001773 0.025115 0 0 0.003902 0.000995 1.08E-05 2.78E-10 0.000417 0 0.000953 0 0.000182 0.007396 0.000853 0.002422 0 0 0 0.0114 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 297 of 848

Klebsiella pneumoniaeSphaerobacterCorynebacterium strain thermophilus NTUH-K2044-08Francisella nigricansstrain tularensisProchlorococcus DSM CN-1-30 20745-08 subsp.Leptotrichia sp.tularensis MED4-08Flavobacterium buccalis strain strain WY96-3418-01Saccharopolyspora C-1013-b-08johnsoniaeClostridium strain erythraea UW101-08 perfringens strain strain NRRL ATCC2338-01 13124-01 0.002685 0.086027 0.234944 0 0.02062 0 0.070786 0.002808 0.00117 0 0 0.166705 0 0 0 1.375411 1.29E-05 1.72E-06 0.001753 0 0.002893 0 0.015611 0 0.699259 3.88E-09 0 0.008119 0.004074 0 0 0.00281 0 0.49183 4.81E-10 8.49E-08 0 0.000336 0 0 0.002115 0 0.623522 0.000157 4.23E-05 0.008349 0 0 0 0 0 1.065853 2.36E-17 0.000264 0 0.00587 0 0 0.019654 0.000266 0.335372 1.86E-05 0.00049 0 0.007657 0 0.01548 0 0 1.583013 0.000571 0.001096 0 For0 0.000802 Peer0 0.017606Review0 0.286355 Only6.57E-06 6.62E-07 0.009369 0.002384 0 0 0.008842 0 1.30675 6.37E-05 8.24E-05 0.006337 0.003032 0 0 0.024076 0 0.79087 4.43E-05 2.44E-06 0.003359 0.004252 0.002503 0 0.049386 0 0.7145 3.81E-08 0.000145 0.007679 0.004643 0 0 0.009188 0 0.928873 2.33E-05 0 0 0 0.019685 0 0.10335 0 0.12215 0.000172 1.13E-05 0 0.004387 0 0 0 0.000614 0.335523 0.000166 0.000809 0.001529 0.000139 0.009309 0 0.611555 5.77E-05 0.086389 0.000471 5.30E-05 0 0.016484 0.001576 0 0.00115 0.001047 0.270313 0.000454 0.000122 0 0 0 0 0.000224 0 0.685225 1.91E-05 0 0.008467 0.003581 0 0.004835 0.017411 0 0.825531 0.000393 2.80E-05

Wiley-Blackwell and Society for Applied Microbiology Page 298 of 848

ClostridiumAcholeplasma botulinum VibrioA strain laidlawii cholerae Hall-01Campylobacter strain strain PG-8A-01 M66-2-01Phenylobacterium lari strainMycoplasma RM2100-08 zucineumGeobacter mobile strain strain sp.Pelobacter HLK1-30 M21-01 163K-01 Acidaminococcuscarbinolicus strain fermentans DSM 2380-01 strain DSM 20731-30 0 0.002436 0.008257 0 0.002692 0 0.010736 0.019445 0.017192 0 1.11E-11 4.73E-05 0 0 0 0.000152 0.000293 0 0 1.86E-15 0 1.83E-14 0.023128 0 2.20E-05 0.002153 0 0 0 7.48E-05 0 0.045336 0 0.0001 7.79E-06 0 0 4.71E-06 0 0 0.0112 0 0.000697 0.003625 0 0 0 0.001337 0 0.122542 0 0.000382 0.002872 0 3.60E-05 0 0.004146 0.002088 0.043319 0 0.001781 0.002781 0 0.000317 0.000578 0.001063 0 6.67E-05 0 0.001088 0.002184 0 0 For0 Peer0 0 0.025757Review0.000732 0.000135 Only0.000462 8.89E-05 0 8.37E-14 0 0.000513 1.77E-06 0 0.001678 0.000996 0 0 0.001316 0 5.66E-11 2.47E-05 0 0.001447 0.001283 0 0 1.48E-05 0 0 0.025667 0 0.000226 0.001062 0 0 3.74E-05 0 0 0.068815 0 0.000253 0.002801 0 3.36E-05 0 0 0.005541 0.003834 0 0.000749 0.003729 0 0 0.002873 0 0 0.030449 0 0.003527 0.005882 0.02433 0 0 0 0 0.014825 0 0.000339 0.000697 0 0 2.91E-15 0 0.00073 0.020913 0 0.002853 0.009722 0.011523 9.23E-06 1.88E-08 0.000567 0.001534 0.009874 0 0.000487 0.00057 0 0 0.000357 0.002301 0 0.018161 0 0.000852 0.000541 0

Wiley-Blackwell and Society for Applied Microbiology Page 299 of 848

NatronomonasCorynebacterium pharaonisPseudomonas strain glutamicum DSMXanthomonas putida 2160-08 ATCC GB-1-01Pseudomonas 13032-30 oryzae pv.Candidatus oryzae aeruginosa strain LactobacillusDesulforudis strain PXO99A-08 PA7-08Campylobacter caseiaudaxviator strainAnaeromyxobacter BL23-30 strain jejuni MP104C-08 subsp. jejuni dehalogenans strain 81116-30 strain 2CP-C-01 0.005264 0.001042 0.008202 0.00846 0.022502 0.045947 0 0 0.002665 0 0 0.002319 0.00386 0.092964 0 0 0 4.72E-07 0 0 0.005117 0.001318 0.035577 1.40E-09 0 0 4.92E-07 0 0 0.007931 0.002456 0.06579 0 0 0 3.78E-18 0 0 0.005021 0.002055 0.029807 0 0 0 6.93E-05 0 0 0.013931 0.008321 0.104824 0.001107 0 0 0.000729 0 0 0.009098 0 0.038314 0.005144 0 0 0.00049 0 0 0.011661 0.011036 0.102445 0 0 0 0.001176 0 0.001966For0.002824 Peer0 0.035394Review0 Only0 0 4.48E-05 0 3.15E-19 0.00782 0.003435 0.085402 6.47E-15 0 0 0.00035 0 0 0.00832 0.003904 0.115991 0.003364 0 0 0.000418 0 0 0.006296 1.22E-07 0.105726 0 0 0 7.92E-05 0.000386 0 0.024134 0.010115 0.140931 0 0 0 0.000229 0 0 0.002471 0.00145 0.008726 0 0 0 0.000155 0 0 0.006984 0.00662 0.053897 0.000127 0 0 0.001377 0.006545 0 0.002565 0.001733 0.034484 0.000163 0 0 0.000291 0.006873 4.34E-05 0.008225 0.00476 0.03785 0.017463 5.79E-08 3.43E-14 0.001178 0 0 0.002078 0.00133 0.031296 0 0 0 3.13E-05 0 0 0.020401 0.008419 0.132246 0 0 0 0.000123

Wiley-Blackwell and Society for Applied Microbiology Page 300 of 848

StreptococcusMycobacterium thermophilusGeobacillus sp. strain MCS-30Clostridium thermodenitrificansCNRZ1066-01Leptospira kluyveri strain strain borgpeterseniiFrancisella DSM NG80-2-01 555-01 tularensisBacillus serovar cereus subsp. SinorhizobiumHardjo-bovis strain mediasiatica AH187-01Shewanella strain meliloti strain L550-01 strainsp. FSC147-01 MR-4-01 1021-30 0 0 0.005997 0 0.003315 0 4.30E-05 0 0 0 0 0.00103 0 0.00082 0 5.01E-11 9.83E-06 0 0.001264 0 0.000671 0 0.000651 0.005395 2.88E-05 0.024346 0 0 0 2.74E-05 0 7.72E-07 0 0 0.009378 0 0 0 0.000265 6.56E-06 0 0.006988 5.52E-05 0.025905 0 1.94E-06 5.50E-06 0.003204 6.80E-05 0 0 0.000131 0.057009 0.003377 0 0.003696 0.002987 0.000512 0.001068 0 0.00011 0.03226 0.002309 0 0.005554 0.005617 0 0 0 0 0.013094 0 0 For0 0.000336 Peer0.000106 0.00057Review0 7.21E-05 Only0.011905 0.001178 0 0.023712 0.000912 0 0.000662 0.006516 1.01E-05 0.000407 0.003178 0 0.059073 0.001915 0 0.000244 0 3.74E-05 0.006705 0.003063 0.000311 0 0.001306 6.61E-07 0 0 0.000264 0.005427 0.001815 0 0.017033 0.003153 9.33E-12 0 0.007038 0 0.013589 0.007657 0 0.011474 0.000849 0 0.00052 0 7.68E-05 0.01219 0.000996 0 0.01275 0.002271 0.000115 1.41E-05 0 0.000206 0.026743 0.00394 0 0.01177 0.000577 2.18E-13 0 0 0.000136 0.011481 0 0 0 0.003 9.98E-05 0.004671 0.021253 2.53E-05 0.023918 0 0 0 0.000128 0 8.19E-05 0 9.33E-05 0.019306 0.001216 0 0 0.002205 0 0 0 3.77E-05 0.013074 0

Wiley-Blackwell and Society for Applied Microbiology Page 301 of 848

NeorickettsiaMethylobacterium risticii strainMethylobacterium Illinois-01 sp. ThermotogaDM4-08 sp. Thiomicrospira4-46-30 sp. RKU-1-08Thermanaerovibrio crunogenaSphingomonas strain acidaminovorans XCL-2-30Ehrlichia wittichii ruminantiumEnterobacter strain strain RW1-30 DSM strain sp. 6589-08 638-01 Welgevonden-01 2.17E-05 0.029002 0.066301 0 0 0.05721 0.111372 0 0.000361 0 0.006178 5.15E-05 0 0 0.001465 0.002551 3.25E-09 0.00019 0 0.007538 0.000357 0 0 0 0.026878 7.21E-05 0.000502 0 0.003065 0.015424 0 0.093566 0 0.003493 0.002727 0.001033 0.001183 0.008977 0.004787 0 0.061224 0 0.023222 0.000621 0.000912 0 0.005458 1.63E-06 0.00552 0 0 0.028378 8.28E-07 0.000814 0.007451 0.007298 0.029541 0 0.048864 0 0.043596 0 0.001765 3.81E-05 0.00252 0 0 0.002198 0 0.00021 1.17E-09 0.002969 4.64E-05 0.003487For0.003367 Peer0.004681 0.097005Review0 0.014005 Only0.000252 0.001882 0 0.004306 0.014598 0 0.164075 0.009186 0.043566 2.01E-06 0.000922 0.002304 0.002994 0 0 0.974446 3.49E-06 0.008658 0 0.001813 0 0.010307 0.001268 0 0.213318 0 0.041867 1.72E-05 0.001346 0.000366 0.007514 0.000248 0 0.136696 0.016902 0.024945 0.000251 0.003561 0.004542 0.001609 0.000479 0 0.084432 0 0.001873 0 0.000263 0 0.003991 0.012846 0 0.278069 0 0.018602 0 0.000648 0.000305 0.003304 0.006313 0 0.056532 0 0.020294 0.000337 0.000127 0.004595 0.015175 0.015593 0 0.104478 0.002705 0.021848 0.000505 0.003681 0 0.003469 0.000212 0 0 0 0.010604 0.000131 0.000128 5.20E-06 0.003656 0.008395 0 0.038975 0.014678 0.017158 0 0.004335

Wiley-Blackwell and Society for Applied Microbiology Page 302 of 848

LactococcusClostridium lactis subsp.Pirellula acetobutylicum lactis strainstaleyiSalinospora KF147-08 strain strain DSMCampylobacter ATCCsp. CNB440-086068-08 824-01Leptothrix curvus cholodnii Methanosphaerulastrain 525.92-30 strainFerroglobus SP-6-01 palustrisBurkholderia placidus strain strain E1-9c-30 sp. DSM CCGE1002-30 10642-08 0 0.003712 1.401038 0.007716 0 0.003608 0 0.005801 0.001295 0 0 0.007198 0 0 0.002272 0 0 0.221671 0 0.000553 0.021794 0.000742 0 0.003001 0 0 0.027287 0 1.48E-16 0.001394 7.92E-09 0 0.001567 0.000747 0 0.083794 0.00108 0.00025 0.006725 0.000447 0 0.003152 0.000298 0 0.006074 0 4.49E-05 0.006086 0 0 0.004412 0 0 0.268496 0 3.31E-05 0.135072 0.004116 0 0.005788 5.93E-06 2.50E-16 0.004953 0 7.74E-07 0.025297 0.00536 0 0.008859 0 0.013597 0.279384 0 4.01E-05For0.015123 Peer0.001692 Review0 0.000599 Only0 0 0.014394 0.001119 0.00067 0.007996 1.52E-05 0 0.003789 0 3.25E-19 0.097818 2.40E-08 0.000627 0.003812 0.001175 0 0.004479 0 0 0.473741 0 0.001357 0.014883 7.61E-07 0 0.00234 0 0 0.022416 0 0.000117 0.009338 0.000313 0 0.012837 0 0 0.053232 0 0.000664 0.009538 0 0 0.002856 0.000414 0.004159 0.014105 0 0.000128 0.240983 0.008571 0 0.00373 0.003794 0.017142 0.012634 0 0.000545 0.358855 7.24E-05 0 0.000778 7.64E-06 0.00261 0.005988 0 0.001605 0.247653 0.000519 2.12E-08 0.001503 0.01911 0.005758 0.017377 0 0 0.005334 0 0 0.001423 0 0 0.057753 0 0.000938 0.001411 0 0 0.006214 0 0 0.071361

Wiley-Blackwell and Society for Applied Microbiology Page 303 of 848

Vibrio vulnificusThermosipho str. CMCP6-01Bifidobacterium melanesiensisEhrlichia adolescentisstrain chaffeensisClostridium BI429-30 strain str.Mannheimia difficile ATCCArkansas-08 15703-08 strainCorynebacterium succiniciproducens R20291-01Prochlorococcus jeikeium str.Finegoldia MBEL55E-01 strain marinus K411-01magna str. MITstrain 9301-01 ATCC 29328-08 0.003935 0 0.013517 0.044799 0.001354 0.001235 0.002573 1.01E-07 0.010486 0.001597 0 0 0 0.000568 0.001382 0 0.000212 0 0.003779 0 0.00064 0.013556 0 0.002475 0 0.001742 0 0.002103 0 0 2.57E-14 0 0.001729 1.15E-07 0 1.09E-06 0.00147 0.023925 0 7.24E-05 0 0.004162 2.61E-08 0.001745 0 0.00479 0 0 0 0 0.006348 0.000104 9.29E-05 0 0 0 0 0.016465 0 0.004746 4.62E-05 6.33E-07 0 0 0 0 0 0 0.008347 0 0.000443 0 0.002025 For0 Peer0 0.015334 Review0 0.001888 Only0 0.001284 0.002395 0.000772 0 0 0.002576 0.00025 0.005615 1.62E-06 0.002232 0 0.000867 0 0 0 9.77E-05 0.003303 3.18E-05 0.001599 0.001308 0.003657 0 0 0.003385 0.00072 0.004985 0 0.000361 0 0.011407 0 0 0 0 0 0.000137 0.000717 0 0.000106 0 0 0.001303 0.000585 0.0028 0.000211 0.001815 0 0.003574 0 0 0.020099 1.37E-10 0.003683 0.000169 0.002911 0.004098 0.0009 0 0 0.015402 0.00019 0.0017 0 0.004501 0 0.004515 0 0.000126 0.028434 0.000433 0.004368 0.000244 0.001674 0.014047 0.000652 0 0 0 0.000511 0.001071 0 5.34E-05 2.02E-18 0.011169 0 0 0.001834 0 0.012325 0 0.003078 0.000204

Wiley-Blackwell and Society for Applied Microbiology Page 304 of 848

Wolbachia sp.Listeria wRi-08 seeligeriBurkholderia serovaralpha 1/2bpseudomallei proteobacterium strainThermomicrobium SLCC3954-30 strain 668-08Listeria IMCC1322-30 seeligeriroseumStenotrophomonas DSM serovar 5159-08Rhodoferax 1/2b strain maltophiliaVibrio ferrireducens SLCC3954-08 fischeri strain strainstrain R551-3-30 ES114-08T118-30 0.03172 0 0.005993 0.420229 0.060009 0 2.86E-20 0 0.012719 0 4.58E-10 0.011231 0.445978 0 0 0 0 0.047081 0.010925 0 0.001193 1.228018 0 0 0.028863 0.003504 0 0 4.44E-10 0.000918 1.811062 0 0 0.003796 0.004639 0.033858 7.88E-06 8.50E-10 0.000904 2.061341 0 0 0.005675 1.08E-05 0.033317 0.002183 4.56E-08 0.002907 0.415882 0 0 0 0.068475 0 0.025243 0.004469 0.001005 0.647672 0.01156 0 0.024159 0.004016 0.022049 6.38E-15 1.39E-07 0.016336 0.454208 0 0.000408 0.05551 0.004127 0.048766 0.019895 1.00E-08For0.002564 Peer1.393824 Review0 0 0.00764 Only0.008115 0.00981 0.006586 0 0.003695 0.434378 0 0 0.002296 0.000252 0.052449 0 0 0.002066 0.622367 0.000615 8.28E-05 0.032664 0 0.06653 0.001343 1.91E-08 0.000801 0.824084 0 0 0.029036 0.034112 0.093069 0.011427 1.29E-09 0.003051 0.759518 7.08E-09 0.001604 0.00304 0.015725 0.089099 0.001677 0 2.70E-05 0.770083 0 0 1.90E-05 0.002918 0.01192 0 0.001006 0.002848 0.542938 0.030388 0 0.065715 0.031235 0 0.002171 0.001438 0.001756 1.327447 0.000662 0.001545 0.009149 0.001056 0.01275 0.008941 0 0.000537 0.640338 0.011472 0 0.012124 0.032766 0.019813 0 0 0.000378 0.786382 0 0 0.000676 0.005431 0.00939 0.009527 0 0.001677 0.732006 0 0 0.007122 0.006349 0.026201

Wiley-Blackwell and Society for Applied Microbiology Page 305 of 848

ProchlorococcusSalmonella sp. MIT9303-30 Pseudomonasenterica subsp.Dichelobacter putida enterica strainMethylobacterium serovar nodosus W619-30 TyphiDeinococcus str. VCS1703A-30str. radiotolerans Ty2-01Caldivirga geothermalis maquilingensisstrainVariovorax strain JCM 2831-30DSM Methanosarcinaparadoxus strain 11300-01 IC-167-01 strain acetivorans S110-01 str. C2A-30 0 0 0.016264 0 0.025668 0.003481 0 0.005219 0.079887 0 9.47E-06 0.049868 0 0.001496 3.27E-05 0 0.001179 0 0.00056 3.70E-05 0.0527 1.52E-09 0.000386 0.000699 0 0.001371 0 0.008205 0.003586 0.133032 0 0.001231 0.001298 0 0.000727 0 0.015016 0.001712 0.04901 0 0.003468 0 8.29E-09 0.001695 1.66E-07 0.035541 0 0.040795 0.119374 0.005476 0.001235 0 0.007721 0 0.026451 0.000976 0.016016 0.009475 0.056774 0.001768 0 0.003328 0.013896 0 0 0.049762 0 0.071501 0.004842 0 0.004592 0.006123 0.028153 For0 0.027197 Peer0.065049 0.002276Review0.000148 Only0 0.001899 3.25E-06 0 0.002358 0.028627 2.96E-06 0.000361 0 0 0.002951 0 0 0.002222 0.108925 0 0.031864 0.0031 7.00E-06 0.002379 0 0.006573 0 0.049789 0.090269 0.011935 0.001004 0 0.002038 0.000147 0.016913 0 0.063415 0 1.29E-15 0.004341 0 0.003507 0 0.103947 0 0.004583 0 0.003647 0.000559 5.46E-05 0.003433 0.001356 1.54E-08 0.002046 0.055768 0.055459 0.026891 0.003723 1.54E-18 0.002439 4.96E-06 0.071937 0.000412 0.038961 0.008195 0.001689 0.000427 0 0.001405 0.006322 0.018954 0 0.028464 0.015518 0.004237 0.003107 0 0.005662 0.004091 0.092505 0 0.032937 0 0.0008 0.000155 0 0.001466 8.05E-08 0 0 0.058825 0.018146 0.006457 0.000311 0 0.003449 0

Wiley-Blackwell and Society for Applied Microbiology Page 306 of 848

BradyrhizobiumZymomonas sp. BTAi1-30Streptococcus mobilis subsp.Coxiella gallolyticus mobilis burnetiiendosymbiont strain strain strain NCIMB UCN34-08Clostridium RSA of11163-01 331-01 AcanthamoebaAcidovorax phytofermentans sp. Borreliasp. UWE25-01 JS42-30 strain burgdorferiBrucella ISDg-01 melitensis str. B31-01 strain ATCC 23457-01 0.107042 0 0 0 0.013837 0.00333 0.106164 0 0.006519 0 0.000698 0.002151 0 0.001307 0 0.001186 0 0 0.007615 0.000224 0 0 0.000316 4.16E-06 0.000722 1.43E-09 0 0.018326 0 0 0.004756 7.94E-14 1.38E-12 0.009205 0 0 0.009156 0.006771 0 0 1.20E-10 0.000444 0.004932 0 0 4.33E-10 0.002029 0 0 4.68E-07 4.42E-05 0.013619 0 0 0.016366 0 0 0 0.000775 0.000736 0.00401 0 0 0.060006 0 0 0 8.33E-12 3.89E-08 2.56E-28 0 0 0.004269 0.003538For Peer0 0.006384 0.000678Review3.86E-15 0.000109 Only 0 0 0.001459 0.003422 0 0 0.002248 4.18E-22 0.001934 0 0 0.021902 0.007454 0 0.010763 0.000125 0.000713 0 1.60E-09 0.000967 0.002456 0.004393 0 0.005308 4.42E-09 0.000579 0.018028 0 0.002776 0.00572 0 0 0 1.20E-08 7.51E-15 0.005461 0 0 0.001895 0.009124 0 0.005892 3.02E-05 0.000222 0 0 0 0.020421 0 0 0 0.001782 0.001379 0.017591 2.74E-14 0 0.008193 0.008307 0 0.006561 2.46E-05 2.40E-05 0.011018 0 0.008253 0.011732 0.008761 0 0 0.001833 0.000939 0.012953 0 0.001347 0.007182 0.001546 0 0 0 3.98E-10 0.008792 0 0 0.01781 0.005641 0 0.022264 6.50E-17 0 0.018681 2.33E-11 0

Wiley-Blackwell and Society for Applied Microbiology Page 307 of 848

ChlorobiumJannaschia limicola strain Shewanellasp. DFL-12-01 DSM 245-01Methanococcus pealeana strainmethanogenic aeolicusATCC 700345-01Rhodobacter strain archaeon Nankai-3-01Buchnera 6A8-01sphaeroides aphidicolaThermotoga strain strainATCCBeutenbergia sp. 17025-30 Tuc7RQ2-08 (Acyrthosiphon cavernae strain pisum)-08 DSM 12333-08 0.010201 0.038653 0.01802 9.12E-07 0.001028 1.31E-07 0 0 0.009835 0.001417 0.038697 0.000998 0 0 0.008093 0 0 0.007464 0.000243 0.084463 0.004793 1.12E-12 0 0.257347 0 0 0.000821 0.001763 0.552769 0.008856 0 0 0.50351 0 0 0 0.000459 0.221099 0.002664 0 0 0.391489 0 0.004651 0 0.002349 0.163163 0.011467 0.000152 0 0.086861 0 0 0 0.003083 0.154513 0.009113 0.002053 0.001695 0.088526 0 0 0 0.002561 0.15351 0.013396 0 3.01E-05 0.12077 0 0 0 0.001634 0.190027For0.004546 Peer0 Review0 0.142524 Only0 0 0.000322 0.00105 0.159282 0.008675 0 0 0.130757 0 0 8.45E-06 0.000539 0.110801 0.00728 6.01E-14 8.12E-07 0.276051 0 0 8.73E-05 0.001354 0.295308 0.003456 0 0 0.078717 0 0 0 0.000918 0.458943 0.018186 0.000492 5.02E-08 0.099417 0.02962 0 0.002767 0.001147 0.159401 0.002081 0 0.00019 0.043948 0 0 2.59E-05 0.002996 0.101533 0.008882 5.61E-12 0.000229 0.037754 0 0.009878 0.000359 0.001064 0.115525 0.00137 0 2.99E-12 0.063238 0 0 0.001805 0.008531 0.079955 0.010369 0.001958 0.000949 0.063304 0.034355 0.006975 0.00169 4.08E-05 0.131315 0.002002 0 0 0.160692 0 0 0.002276 0.002111 0.520081 0.019003 0 4.54E-06 0.126062 0.123778 0 0.000486

Wiley-Blackwell and Society for Applied Microbiology Page 308 of 848

BifidobacteriumYersinia animalis pestisDesulfomicrobium subsp. strain Z176003-30lactisStaphylococcus strain baculatum DSMEscherichia aureus10140-08 strain Aquifex colisubsp. DSM strain aureus 4028-08aeolicus MG1655-30Burkholderia str. str. MW2-01 VF5-08Pelobacter pseudomallei Halobacteriumpropionicus strain 668-01 strain sp. DSMNRC-1-30 2379-08 0 0 0.05608 0 0 0.048838 0.000533 0.045857 0 0 0 0.021241 0 0 0 0.000111 0 0 0.002232 0 0.000618 0 0 0 0.000212 0.005097 0 0 0 0.003898 0 0 0 0.000588 0.000216 0 0 0 0.003119 0 0 1.48E-07 0.000594 0.009541 0 0 0 0.012283 0 0 0 0.000593 0.004194 0 0 0 0.00276 0 0 0.002762 0.000836 0.015274 0.027038 0 0.052542 0.023041 0 0 0.004753 0.000742 0.000431 0 0 0.014333For0.00686 Peer0 Review0 0.000486 0.000175 Only 0 0 0 0 0.028837 0 0 0.001824 0.000298 0.000688 0 0 0 0.010784 0 0 0.000839 0.000251 0.005467 0 0 0 0 0 0 0 8.06E-05 0.017694 0 0 0 0.015579 0 0 0 0.000902 0.003355 0 0 0.011743 0.000528 0 0 0.002869 8.40E-06 0.001342 0 0 0 0.006324 0.000549 0 0.002395 0.000377 0.030977 0.001084 0 0 0.0025 0 0 0.000902 0 9.35E-05 0 0 0 0.018399 0 1.21E-09 0.004311 0.000731 0.01733 0.000447 0 0 0.008269 0.000759 0 0 2.24E-06 1.16E-08 0 0 0 0.006413 0 0 0 0.000245 8.74E-05 0

Wiley-Blackwell and Society for Applied Microbiology Page 309 of 848

Vibrio fischeriArthrobacter strain MJ11-01Thermococcus aurescensDickeya strain gammatolerans TC1-08 dadantiiSulcia strainmuelleri strainEscherichia Ech586-30 EJ3-08SMDSEM-01 Corynebacteriumcoli strain IAI1-01Deferribacter glutamicumBurkholderia desulfuricans ATCC 13032-08cenocepacia strain SSM1-08 HI2424-01 0.003285 0 0.005129 0 3.14E-09 0.000702 9.86E-13 0.106202 0.003539 0.001531 0.006382 0 0.000103 0.100653 0 0 0.0018 0.000269 0.003526 0.000994 0 0.000191 0.009329 0 3.57E-05 0.000243 0.000333 0.00207 0.000947 0 0.027013 0.058802 0 0.000134 0.005901 9.56E-05 0.003398 0.00356 0 0.016957 0.005298 0 0 5.76E-05 0.000425 0.006351 0.002766 0 0.039943 0.022494 1.90E-05 0.000137 9.71E-08 0.00033 0.005884 9.20E-05 0 0 0.014344 0.000266 0 0.030912 0.001233 0.010861 0.013467 0 0 0.061844 0 0.000395 0.001156 0.000442 0.003518 3.83E-06For Peer0 0.012256 0.011825Review0.000257 Only0 0.000902 0.000336 0.002795 0.001253 0 0 0.006322 0.000163 8.18E-05 0.005508 0.000718 0.005531 0.004196 0 0 0.04119 0 2.17E-06 0.001015 0.000223 0.003728 0.002184 0 0 0.002501 0 0 2.16E-08 0.000464 0.01943 0.005422 5.41E-12 0.006356 0.012523 0 0 0.005066 0 0.002622 0 0.000242 1.65E-06 0.008927 0 0 0.001019 0.000608 0.003949 0.005493 1.94E-08 0 0.015373 0 0 0.032264 0 0.001858 1.39E-05 0 0.003163 0.000395 0 0.000284 0.004298 0 0.008515 0.003353 0.000969 0.00203 0.010386 0 0 0.02688 0.002059 0 3.47E-06 0 0.01081 0.011189 0 0 0 7.44E-05 0.006034 0.011938 0 0.000439 0.014491 0.00046 0 0.005421 0.000484

Wiley-Blackwell and Society for Applied Microbiology Page 310 of 848

Sulfolobus islandicusiron-oxidizing strainCenarchaeum lithotroph M.14.25-01Paracoccus ES-1-30 symbiosum Desulfitobacteriumdenitrificans A-01 Sebaldella PD1222-30 sp. termitidisHelicobacter Y51-08 strainAgrobacterium pylori ATCC strain 33386-01Ralstonia G27-08 vitis strain solanacearum S4-30 strain IPO1609-30 0 0 1.705489 0.043514 0.009655 0.00013 0 0.000998 0 0 0.13628 0 0.131129 0.004242 0.000877 0 0.005797 0 0 0.024164 3.11E-05 0.149967 0.002014 0 0 0.01278 0.001498 0 0.075874 0 0.430342 0 0 0 0.076388 0.004668 0 0.032034 0 0.254881 0.000141 2.03E-05 0.00755 0.035139 0.001311 0 0.008805 0.006 0.039295 6.42E-05 0.000217 0 0.026592 0.000878 0 0.022157 0.097234 0.096214 0.006204 0.00072 0 0 0.001765 0 0 0.032225 0.098972 0 0 0 0.009783 0.09633 1.84E-12 0.011065For Peer0 0.118689 0.000609Review1.57E-14 Only0 0.016788 0.001245 0 2.57E-05 0.006887 0.132059 0.001725 4.47E-16 0 0.007356 0.004329 0 0.187158 0.006058 0.120532 0 5.37E-05 0 0.027296 0.000839 0 0.000655 0 0.102141 0 2.68E-08 0 0.001844 5.13E-05 0 0.141799 0.000957 0.102702 0.000381 0.000913 0 0.032899 0 0 0.026721 0.000476 0.02922 0.005028 0.000135 0 0.003363 0.006036 0 0.123397 0.174721 0.107208 0.004734 6.17E-07 0 0.018264 0.007242 0 0.061505 0.000423 0.072362 0 7.70E-05 0 0.001832 0.002806 0 0.025497 0.171263 0.046129 0 0.00106 0 0.028295 0.003009 0 0.042637 1.69E-14 0.103839 0 6.52E-07 0 0 0.004699 0 0.034956 6.90E-05 0.069876 0.00066 1.00E-18 0 0.023998 0.000176

Wiley-Blackwell and Society for Applied Microbiology Page 311 of 848

Escherichia Verminephrobactercoli strain ED1a-08Vibrio harveyi eiseniaeBordetella strain strain ATCC pertussisPseudomonas EF01-2-01 BAA-1116-01 TohamaStaphylococcus syringae I-30 Azoarcus pv. tomatoepidermidis sp.Geobacillus str.BH72-01 DC3000-08 ATCC Dehalococcoides12228-30 sp. WCH70-01 sp. BAV1-30 0 0.010928 0.003154 0.008927 0.024409 0 0.023646 0.02962 0 0 0.002648 0.00193 0.012306 0.076785 0 0.004279 0.003262 0 0.00305 0.003719 0.002915 0.002771 0.02024 0 0.00387 0.0046 0 0 0.005192 0.006725 0.034052 0.040774 0 0.008256 0 0 0.003709 0.004129 0.003274 0.004562 0.017746 0 0.004927 0.001083 0 0 0.008429 0.00682 0.012977 0.075304 0 0.005779 0.000502 0 0.001659 0.005114 0.005116 8.32E-09 0.02549 0 0.008127 0.00307 0 0.005834 0.008731 0.0079 1.30E-05 0.070546 0 0.007526 0.000494 0 0.00583 0.001885For0.002145 Peer0.003737 0.016471Review0 0.007244 Only9.57E-05 0 0 0.00626 0.004295 0 0.049921 0 0.006816 0.001912 0 0.00413 0.007772 0.003487 0.019717 0.068726 0 0.005976 0.001139 0 0.009153 0.003202 0.002441 0 0.031391 0 0.003822 0.001451 0 0 0.009447 0.014568 0.024417 0.089614 0 0.007339 0.000251 0 0 0.002805 0.001114 0 0.002554 0 0.003097 0.000303 0 0 0.003161 0.003511 0.006689 0 0 0.006387 0.006845 0 0 0.003276 0.001894 0.003228 0.016345 0 0.005544 0.002071 0 0.001743 0.006296 0.006293 0.009689 0.022545 0.010401 0.009803 0.004394 0.019089 0 0.001694 0.000874 0.004045 0.02208 0 0.001767 0.006078 0 0 0.003882 0.008244 0.011891 0.088002 0 0.005296 0.002562 0

Wiley-Blackwell and Society for Applied Microbiology Page 312 of 848

CyanotheceDesulfovibrio sp. BH68K-08Burkholderia desulfuricansAcidithiobacillus multivorans subsp.Serratia desulfuricans strain ferrooxidans proteamaculans ATCCLeifsonia strain 17616-01 str. xyliATCC BrucellaATCC subsp.strain 27774-30 23270-30 canis568-30xylikorarchaeote strain strain CTCB07-01 ATCCBurkholderia OPF1-KOR-08 23365-01 mallei str. ATCC 23344-08 0.006557 0 0.000598 0 0.045132 0.005374 0 0 0.001178 0.007432 0 0.000316 0 0 3.72E-17 0 0 0.007963 0.013941 0 0.000479 0.012576 0.000867 0.000142 0 0 0.002856 0.006423 0 2.78E-05 0 0.02765 0 0.007106 0 0.000327 0.006233 0 0.000171 0.002748 0.004861 0.000236 0 0 0.000239 0.005261 0 0.000726 0 0 5.52E-05 0 0 0.007629 0.008253 0 0.000899 0.00554 0.001405 0.002614 0 1.06E-10 0.000501 0.023699 0 0.001392 0 0 0.000193 0.009229 0 0.00123 0.004718 8.51E-17For0.000151 Peer0.00806 0.020163Review2.29E-05 Only0 0.008019 0 0.00879 0 0.000235 0 0.028278 4.95E-05 0 0 0.002391 0.005173 0 0.000552 0.027265 0.016389 0.001166 0 0 0.000895 0.02004 0 0.00027 0.000619 0.017758 0.000153 0.012713 0 0.000861 0.008054 0 0.000588 0.047887 0.00686 0.000512 0 0 3.23E-06 0.010947 0.002204 0.000452 8.89E-07 0.000399 0.001569 0 0 0 0.006966 4.44E-05 0.000639 0.01877 0.001 0.001858 0.008669 0.0016 0 0.005856 0 8.88E-05 0 0.004206 3.14E-07 0 0 0.00153 0.002756 0.010059 0.001482 0.029033 0.025667 0.000122 0 0.003819 0.00114 0.010418 0.021789 4.09E-05 0.049308 0.029706 2.95E-05 0 0 0 0.008433 0 0.000366 0 0.011564 0 0.007947 0 0.00528

Wiley-Blackwell and Society for Applied Microbiology Page 313 of 848

ShewanellaXanthomonas amazonensisEscherichia strainoryzae SB2B-30 pv. Ignicoccuscoli oryzae strain strain 536-08sp.Escherichia Kin4-I-01 PXO99A-30 Pseudoalteromonascoli IAI39-30Campylobacter atlanticaDiaphorobacter hominis strainNeisseria strain T6c-01 sp. ATCCTPSY-08 gonorrhoeae BAA-381-08 strain FA 1090-30 0.040013 2.98E-09 0 4.22E-15 0 0.038557 0 0.080924 0 0.095918 0.077802 0 0 0 0.004031 0 0.011749 0.113057 0.006705 0.000434 0 0 0 0.009661 0 0.00509 0 0.039823 0.009323 0 0 0 0.026011 0 0.003563 0 0.048995 0.004063 0 0 0.007011 0.01717 0 0.006212 0 0.187978 0.00235 0 0 0 0.022256 0 0.024419 0 0.077919 0.00883 0 1.46E-12 0 0.019909 0 0.008723 0.030969 0 0 0 1.05E-14 0 0.029907 0 0.016016 0.138229 0.044341 0.007604For Peer0 0 Review0 0.012037 Only0 0.00749 0 0.11181 0.001751 0 3.89E-05 0 0.013496 0 0.009205 0 0.051152 0.002889 0 0.003654 0 0.018784 0 0.008551 0.117248 0.181022 0.001758 0 0 0 0.021265 0 0.010406 0.021292 0.108901 0.003344 0 0 0.003797 0.0439 1.76E-10 0.022486 0 0.014472 0.001405 0 0 0 0.007675 0 5.31E-05 0.00759 0.092457 0 0 2.61E-11 0 0.017327 6.41E-05 0 0.044408 0.075725 0.002118 0 0 0.005872 0.007281 0 0.002948 0.017055 0.014281 0.005184 0.001202 0 0.001638 0.023123 0 0.007146 0.01174 0.104825 0.007992 0 0 0 0.008527 0 0.008795 0 0.037862 0.002973 0 0 0 0.040165 0 0.015354 0

Wiley-Blackwell and Society for Applied Microbiology Page 314 of 848

BifidobacteriumBrucella longum melitensisChlorobaculum subsp. biovar infantisTolumonas Abortus parvum strain Lactobacillusauensis ATCCstrainstrain 15697-30 2308-01NCIB strainPsychrobacter 8327-08brevis DSM 9187-30strainXanthomonas cryohalolentisATCC 367-30Lactococcus oryzae strain pv.Xylella lactis K5-30 oryzae subsp.fastidiosa strain lactis MAFF strain strain 311018-01 M23-01 Il1403-08 0 0 0.075128 0 0 0 0 0 0.003362 0 0 0.003352 0.417026 0 0 0 0 0.001321 0 0 0.000374 0.017793 0 0 0 0 0.001122 0 0 0.013956 0.224504 0 0 0 0 0.000329 0 0 0.002546 0.055998 0 0.060208 0.001404 0.00134 0 0 0 0.003126 0.190108 0 0.000101 0 0 0 0 0 0.015726 0 0 0.010873 0.001807 0 0 0 0 0.003793 0 0 0 0 0 0 0 For0 0.005721 Peer0.091947 0.00204Review0.120391 0.000834 Only 0 0 0 0 0.003145 0.072917 0.033186 0.001486 0 0.002778 0.002003 0 0 0.008862 0.125051 0 0.037397 0.001101 0 0.002508 0 0 5.09E-07 0.227508 0 0.082299 0 0 0.001648 0.034157 0 0.005696 0.099353 0 0.003813 0 0 0 0 0 0.00107 0.057343 0 0 0 0 0.001769 0 0 0.010065 0.055193 0.002238 0.077413 0.001944 0 0.001256 0 0 0.006184 0.138648 0 0.023109 0 0 0 0 0.010367 0.015677 0.026528 0 0.027946 0 0 0 0 0 0 0.047441 0 0.078168 0.000535 0 0 0 0 0.003844 0.037032 0 0.083469 0 0 0.000777

Wiley-Blackwell and Society for Applied Microbiology Page 315 of 848

Buchnera aphidicolaStreptococcus strainBradyrhizobium mutans Tuc7 (Acyrthosiphon Lactobacillusstr. UA159-30 japonicumBradyrhizobium reuteri pisum)-01 str. USDA strainNitratiruptor 110-08 DSM japonicum 20016-01Coxiella sp. str. SB155-2-01 burnetiiUSDALeptospira 110-30 strain interrogansClostridium Dugway 5J108-111-08 serovarbotulinum Lai E3str. strain 56601-01 Alaska E43-30 0 0 0.093092 1.56E-05 0.137701 0.00026 0 0.013322 0.004166 0 0 0.018315 0 0 2.46E-08 0.022805 0.000583 0 0.002067 0 0.010656 0 0.006833 0.001045 0 0.001293 0.009939 0 0 0.017766 0 0.010785 5.30E-05 0.028285 0.000161 0 0.012972 0 0.024746 0 0.034122 4.34E-06 0 2.03E-05 0 0 0 0.015553 8.17E-16 0 0.002176 0 0.001688 0 0.005019 0 0.034125 0 0.011524 0.002067 0.050513 0.002442 0 0 0 0.039153 0 0.025579 0.003647 0.072893 0.003351 0 0 For0 0.008181 Peer0 0.009016Review0.004314 Only0 0.000507 0 0 0 0.015914 0 0.014087 5.60E-06 0.039444 0.001945 0 0 0.10824 0.016757 9.51E-05 0.048284 0.002431 0.066615 0.00184 1.23E-08 0 0 0.019494 0 0.044363 0.000467 0 0.000534 0 0 0 0.038807 0 0.033608 7.97E-06 0.094839 0.001325 0 0 0 0.004499 0 5.28E-05 0.001407 0 0.000684 0 0 0 0.028369 0.001102 0.07873 0.005613 0 0.003265 0 0 0 0.020084 0 0.008739 0 0 0 0 0 0 0.028437 0 0.013193 0.004677 0.047502 0.003958 0.001013 0 0 0.007234 0 0.005986 2.20E-06 0 0.000634 0 0 0 0.018185 0 0.009176 0.000793 0.044688 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 316 of 848

Vibrio vulnificusThiomicrospira str. YJ016-08Lactococcus crunogenaSalmonella lactis strain subsp. XCL-2-08 Sulfolobusenterica cremoris subsp. islandicusMethanosphaera strain enterica MG1363-30 strainEscherichia serovar L.D.8.5-08 stadtmanae Paratyphi Francisellacoli UMN026-01 strain A tularensisstrainCampylobacter DSM AKU_12601-08 3091-01 subsp. hominis tularensis strain strain ATCC WY96-3418-30 BAA-381-01 0.021076 0.025359 0 0 0 0.001607 0.001442 0 0.004198 0.01727 0.172073 0 0 0 0 0.001324 0 1.21E-10 0.014433 0.077879 0 0 0 0 0.000849 0 4.03E-09 0.044788 0.098836 0 0 0 0 0.00206 0 0 0.017949 0.041483 0 0 0 0 0 0 0.001273 0.064394 0.184953 0 0 0 5.28E-07 0.000191 0 2.11E-08 0.020892 0.077206 0 0 0 0 0.000369 0 0.000895 0.057126 0.176872 0 0 0 2.19E-13 0 0 0.002211 0.028268 0.072937For Peer0 0 Review0 0 0.001009 Only0.031061 0 0.045309 0.133255 0 0 0 0 0.000148 0 0 0.040015 0.217588 0 0 0 5.29E-07 0.000361 0 0.000459 0.070271 0.023338 0 0.006067 0 0 0.000284 0 0.001635 0 0.305459 0.008406 0.015557 0 0 0.001616 0 0.000286 0.005313 0.017478 0 0 0.000304 1.78E-05 0.000575 0 5.82E-05 0.039233 0.129489 0 0 0 0.002515 0.001133 0 0.000261 0.02644 0.044841 0 0 0 0 0.000793 0 0 0.02922 0.081126 0 0.003789 0 0.001276 0.000286 0.027056 0.000701 0.032357 0.091082 0 0 0 3.57E-08 0.000211 0 4.76E-08 0.086629 0.241131 0 0 0 0 0 0 3.70E-12

Wiley-Blackwell and Society for Applied Microbiology Page 317 of 848

Rickettsia conoriiBaumannia strainBurkholderia cicadellinicola Malish 7-08Methanospirillum cenocepacia str. Hc (HomalodiscaShigella AU hungatei1054-30 sonneiSynechococcus coagulata)-01 strain strain Ss046-08 MethanosarcinaJF-1-08 sp. WH7803-01Escherichia mazei Mycobacterium colistrain O157:H7 Go1-08 str. leprae EC4115-01 strain TN-08 0.027751 0 0.02335 0.010524 0 0.000237 0.026873 0 0 0 7.29E-13 0.035774 0 0 0.004622 3.76E-06 0 0 0 0 0 0 0 0.001501 0.000103 0 0 0.012236 0 0.018952 0 0 7.72E-10 0 0.001803 0 0 0.000622 0.008943 0 0 0 3.54E-07 0 0 0 0.004843 0 0 0 0.001783 0 0.000299 0 0 0.001045 0.007671 1.70E-13 0 0.00122 0.003088 0.000333 0 0 0.000384 0.135987 0 0 0.00016 0 0 0 0 0.007426For0.001972 Peer0 Review0 0.001217 Only0 0 0 0.002331 0.003556 0.000171 3.47E-17 0 0.001649 0.000188 0 0 0 0 0.037286 1.02E-07 0.000217 0.001881 0.002405 0 0 2.05E-12 0.008602 0.009649 0 0 0.000562 0 0 0 0 0 0.00289 1.07E-08 0 3.73E-05 0.001651 0 1.74E-05 0 0 0 0.00013 0 0.010714 0.004049 0 0 0 4.65E-05 0.00937 0.016771 0 0.000349 0.004823 0.000108 0 0 0.004988 4.31E-05 0.006901 0 0.004198 0.000287 0 9.15E-05 0.00401 0 0.006059 0.008068 0 0.002373 0.000656 0.000441 0 0 0 0.00016 0 0 0 2.76E-08 0 0 0 0 0.003616 0.004821 0 0 0.001984 0.001706 0

Wiley-Blackwell and Society for Applied Microbiology Page 318 of 848

StaphylococcusLactobacillus aureusChlamydia subsp. sakei aureussubsp. trachomatisClostridium sakeistrain strain ED98-01Streptomyces botulinumstrain 23K-01 B/TZ1A828/OT-30 ClostridiumB strain avermitilis EklundEscherichia botulinum str. 17B-01 MA-4680-08 BacilluscoliB1 strain O103:H2 cereus Okra-01Syntrophobacter strain strain 12009-08 Q1-08 fumaroxidans strain MPOB-08 0 0 0 0.000703 0.004351 7.49E-05 0.00353 0 0.030167 0 0 0 5.60E-09 0 0.004343 0 0 7.82E-05 0 0 0 0.00029 0.00153 0.00166 0 0 0.005219 0 0 0 0 6.42E-06 3.68E-06 0 0 0.000201 0 0 0 0.000318 0.000761 2.19E-05 0 0 0.005032 0 4.07E-06 0 9.51E-05 0.006809 0.000122 0 0.000182 0.008073 0 0 0 0.000332 0.00275 3.02E-05 0 0 0.005394 0.000163 0.000462 0 0.000288 0.003749 0.000365 0 0 0.006126 0 For0 Peer0 0.000101 1.55E-13Review2.41E-05 Only0 0 0.006978 0.000206 0 0 0 0.00257 1.16E-05 0 0 3.45E-05 0 0 0 3.81E-05 0.001485 0.000893 0 0 0.005805 0 0 0 0.000279 0.006138 1.81E-05 0 0 0 5.57E-09 0 0 0 0.010222 0.000118 0 0.000106 4.25E-08 0 0.000289 0 0.000679 1.36E-13 5.01E-05 0 0 0.001094 0 0 0 0.001356 0.001668 0.001574 0 0 0.015445 0 0 0 1.63E-05 0.000227 8.23E-06 0.001392 2.57E-05 0.001275 0 0.000591 0.01486 0.000503 0.002381 9.15E-05 0 0.000451 0.010847 0 0 0 0 4.16E-09 7.74E-06 0 0 4.65E-14 0 0 0 0 0.006569 1.03E-05 0.003104 0 5.08E-06

Wiley-Blackwell and Society for Applied Microbiology Page 319 of 848

Xylella fastidiosaSynechococcus 9a5c-08Salmonella sp. CC9311-01 bacteriumenterica subsp. Ellin6076-30Mycobacterium arizonaeElusimicrobium serovar tuberculosis 62:z4;z23:---08Coxiella minutum strain burnetiiBacillus H37Rv-01 strain str. cereus RSAPei191-01Slackia 493-01 ATCC heliotrinireducens 14579-01 strain DSM 20476-30 0.010415 0.004652 0 0.067448 0 0 0 3.79E-05 0 0.013063 0 0 0 0.000123 0 0 2.73E-07 0 0.00604 0 0 0 0 3.99E-06 0 0 6.48E-05 0.012711 6.36E-09 0 0.000119 0 0 0 0 0 0.002591 0.002375 0 0 0 0.000637 0 0 0.000682 0.017805 0 0 0.03763 0 2.21E-05 0 0.000125 0 0.005643 0 0 0.00928 0 2.80E-16 0 0.00012 0.018149 0.031951 0.000429 0 0 0 4.09E-05 0 0 0.155856 0.007064 0.0803For Peer0 0.005269 Review0 0 0.00539 Only5.70E-05 0 0.006055 0.00267 0 0.00016 0 0 0 2.19E-05 0.001007 0.008694 0.00287 0 0 0 2.11E-05 0 0.000148 0 0.027363 0.00783 0 0.006138 0 0.001707 0 0 0 0.019046 0 0 0 0 0.002418 0.012944 0 0 0.000915 0.055064 0 0 0 0.000327 0 5.05E-05 0 0.014297 8.67E-05 0 0.030817 0 0.002979 0.01073 0 6.71E-05 0.007691 0.035242 0 0.000381 0 0 0 0 0 0.010251 0 0 0.024465 0 0.002018 0 3.05E-05 0.001762 0.003835 9.17E-07 0 0 0 0.000544 0 5.18E-10 0 0.012259 0.001252 0 0 0 8.85E-06 0 0.000116 0

Wiley-Blackwell and Society for Applied Microbiology Page 320 of 848

AnaeromyxobacterPelotomaculum sp.Zunongwangia K-08 thermopropionicumBurkholderia profundaStreptococcus malleistrain strain SM-A87-01strain SI-01Bacillus uberis 10229-01 cereus str.Streptococcus 0140J-08 strain G9842-08Diaphorobacter suis strainEscherichia SC84-08 sp. TPSY-01 coli strain SMS-3-5-30 0.020938 0.024289 0.103565 0.00069 0 7.16E-11 0.008911 0.010087 0 0 0 0.112671 0.000163 0 0 0 0.000935 0 0.004234 8.41E-06 0.147952 0.000166 0 4.19E-05 0.012177 0.002336 0 0.00159 0 0.241795 0 0 0.000125 0 0.000944 0 6.41E-09 0.000976 0.175563 5.14E-06 0 0.000572 0 0 0 0.000353 8.58E-05 0.39509 0.000822 0 0 0 0.002544 0 0.009011 1.04E-05 0.157297 0 0 1.05E-06 0 0.00307 0 0.002375 0 0.477939 0.001376 0 0 0 0 0 0.000559 0.000349For0.127459 Peer0 Review0 0 0.006087 Only0.002173 0 0.001266 3.32E-05 0.231456 0.000529 0 0 0 0.002967 0 0.002349 0.000158 0.235915 0 0 0 0 0.002056 0 0.001525 0.000611 0.246064 0.000303 0 0 0 0.002679 0 0.001004 0.001311 0.512574 0 0 0.000452 0 0.002149 0 0.001897 0.000909 0.158385 0.000265 0 0.00122 0 0.001615 0 0.010292 0.002088 0.119333 0.000524 0 0.000847 0 0.002704 0 0.000648 2.82E-05 0.057988 1.19E-05 0 0 0 0 0 0.009227 0.001582 0.183033 0.000311 0.001418 0.000347 0.003147 0.00648 3.07E-05 0 3.87E-07 0.101812 6.00E-05 0 0 0 0.000675 0 9.07E-05 1.09E-06 0.501717 0 0 0 0 0.00541 0

Wiley-Blackwell and Society for Applied Microbiology Page 321 of 848

ChlorobiumRothia phaeobacteroides mucilaginosaCandidatus strain strain XanthomonasSulcia DSM DY-18-08 muelleri 266-01Pasteurella oryzae strain pv.GWSS-01 Burkholderiamultocida oryzae strain subsp.Nitrosomonas ambifaria KACC10331-08 multocidaShewanella strain eutropha strain MC40-6-08not balticaPm70-01 strain Oenococcus strainC91-08 OS195-30 oeni MCW-01 0.008708 3.00E-05 2.39E-09 0 0.007548 0.007419 0.092713 0 0 4.17E-06 0 0.000431 0.003991 4.28E-06 0.003756 0 0.073787 0 0.000295 0.005044 0.002758 0.001475 0.002034 0.002253 0.020143 0.003662 0 0.002838 0.001262 0.000136 0.002206 0.003546 0.004374 0.014302 0.060727 0 0.000153 0.002281 0 0.002131 0.005815 0.00276 0.010583 0.037923 0 8.01E-06 0 0.01496 0.008949 0.008138 0.00328 0.042475 0.002424 1.07E-07 0.001976 0 0.009228 0 0.005728 0.001639 0.038088 0.02673 7.72E-06 0.000265 0 0.032958 0.012722 0.012254 0.002886 0 0 0 0.000488 For0 0.000345 Peer0.000116 0.004559Review0.002678 0.008004 Only0.024061 2.24E-07 0.000915 0 0.003396 0.00331 0.004876 0.002773 0.012472 0.006247 0 0.000399 0 0.031998 0.003091 0.002337 0.004454 0.014541 0.010553 0 0.000489 0 0.014144 0 0.004524 0.004233 0.024732 0.037384 0 0.000406 0.006419 0.015659 0 0.024467 0.006537 0.021869 0.00156 0 0.000323 0 0.010921 0.001209 0.00271 0.000246 0.015763 0 0 0.00018 0 0.004347 0 0.003194 0.000573 0.054649 0.017131 0 0.000274 0 0.000643 0.001528 0.000784 0.002151 0.00736 0.01653 0 0.002758 0.005077 0.01086 0.00405 0.012327 0.004698 0.069821 0.006997 0 0.000725 0 0.005203 0.001342 0.003557 0.002177 0.0269 0.026975 0.001011 9.90E-05 0.001241 0.026604 0 0.016116 0.004152 0.023153 0.01578 0

Wiley-Blackwell and Society for Applied Microbiology Page 322 of 848

AnaeromyxobacterListeria monocytogenes sp.Seattle K-30 AquariumNeisseria strain strain EGD-e-30 meningitidisListeria SCM1-01 monocytogenes Escherichiaserogroup B Allochromatiumcoli strainstrain 55989-01 MC58-01Clip80459-30Methanopyrus vinosumRalstonia strain kandleri DSMpickettii str. 180-01 AV19-01 strain 12J-30 0.073166 0 30.1657 0.000333 0 0 0.05809 0.037511 0.019332 0 0 0.013854 0.000968 0.549843 0 0.006408 0 0.010535 0 0 0.019232 0.001323 0 0 0.010293 0 0.000482 0 0 0 0.003648 0 0 0.012816 0 0.017666 0.008849 0 3.17E-06 0 0 0 0.008687 0 0.000912 0 0 0.288457 0.004391 0.567802 0 0.028671 0 0.000876 0.01976 0 7.467151 0.00655 0.155624 0 0.031707 1.22E-13 0.000336 0 0 1.801279 0 0 0 0.024764 0 0.092653 0.000892 For0 0.008971 Peer0 0.050007Review0 0.018241 Only 0 0.013396 4.21E-16 0 0.623974 0 0 0.000324 0.017454 0.000617 0.004317 0 0 0.421317 0 0.595718 0.000522 0.021093 0 0.000837 0 0 0 0 0 0.000169 0.007189 0 0.015371 0 0 0.081921 0.007187 0 0 0.039871 0 0.00011 0 0 0.091203 0 0 7.89E-06 0.015298 0 0.005683 0.017713 0.000908 15.1692 0.005412 0 0.000237 0.027364 4.09E-12 0.019784 5.84E-07 0 0.000327 0 0.174454 0 0.005346 0 0.001388 0.017124 0 11.92267 0 0.015839 0.000123 0.035664 2.28E-17 0.010378 0.010659 0 0.002665 0 0.149879 6.75E-05 0.00503 0 0.009373 0.01513 0 0.058051 0.00496 0 0 0.039083 0 0.015149

Wiley-Blackwell and Society for Applied Microbiology Page 323 of 848

CloacamonasRickettsia acidaminovorans-08 typhiThermotoga str. Wilmington-30Helicobacter maritima strainEscherichia hepaticus MSB8-30 Nostoc colistr. strainATCC sp. 51449-30 536-30PCC73102-30XanthomonasShewanella campestrisThermomicrobium sp. pv. WP3-30 campestris strain roseum 8004-30 DSM 5159-30 0.068966 0 0.120412 0 0 0.016506 0.223339 0 0 3.33E-17 0 0 0 0 0.1626 0.078392 0.004392 0 0.004788 0 0 0 0 0.012179 0.026841 0.003402 0 0 0.093919 0 0 0 8.28E-07 0.025569 0.057594 0 0 0 0 0 0 0.000652 0.040896 0.038952 0 0.003179 0 0 0 0 0.088252 0.154304 0.175986 0 0.007887 0 0 0 0 0.001124 0.025149 0 0 0.004917 0 0 0 0 0.065655 0.180846 0.095497 0 0.000249 For0 Peer0 0 Review0 0.001775 0.003996 Only0.051051 0 0.003587 0 0 0 0 0.003269 0.041728 0 0 0.009523 0 0 0 0 0.045876 0.202913 0.02708 0 0 0 0 0.015036 0 0.007984 0.017683 0.23066 0 0.00233 0 0 0 0.001184 0.005319 0.027875 0.117512 0 0 0.0024 0 0 0 0.01043 0.002361 0.007275 1.70E-12 0.010607 6.01E-08 0 3.74E-05 0 0.02626 0.016913 0.066815 0.020443 0.014409 0 0 0 0 0.012957 0.006506 0.064064 0 0.004605 0 0 3.11E-13 0 0.006493 0.014195 0.045225 0.033092 0 0 0 0 0 0.016552 0.000822 0.113465 0.017492 0 0.000464 0 0 0 0.027275 0.02508 0.043671 0

Wiley-Blackwell and Society for Applied Microbiology Page 324 of 848

MacrococcusEubacterium caseolyticusBartonella rectale strain strainJCSC5402-30 grahamiiBacillus ATCC cereus strain 33656-08Mycobacterium strainas4aup-08 03BB102-08Geobacillus smegmatisClostridium sp. WCH70-30 strain KlebsiellaMC2 botulinum 155-30 pneumoniae ClostridiumE3 strain Alaska strainperfringens E43-01 NTUH-K2044-01 strain ATCC 13124-08 0 0 0 0 9.38E-13 0.011369 0.000811 0.000267 0 0 0 0 0 0 0 1.86E-09 0.000315 0 0 0 0.00361 0 0.001196 0 0.000317 0.000344 0.000325 0 4.28E-05 0.006101 0 0 0 0 0 0 0 0 0 0 0 0 0.000352 0 0 0 0 0.000921 0 0 0.060808 0 0.001438 0 0 0.004748 0.018293 0 0.01773 0 0.000306 0.001296 0.002208 0 0 0.007774 0 2.47E-05 0 0.000379 0.00133 0 1.90E-06 For0 Peer0 0 1.31E-09Review0.011161 0.000447 Only0.000461 0.001325 0 0 0.004985 0 0 0 0 0.000397 0.001422 0 0.00898 0 0.000453 0 0.019756 1.05E-05 0 0 0 0.000191 1.25E-05 0 0.011713 0 0.000309 0.00115 0 0 0 0 0 0 0 0 0 0.001206 0 0 0 0 0.000968 7.96E-09 3.33E-08 6.93E-05 0.004421 0 0.000671 0.016654 0 0.002206 0 0.000315 0 0 0.001299 1.20E-05 0.005871 0 0.004987 0.001485 0.000509 0 0 0.00594 0.001378 0.017793 0 0.000432 0.00515 0.000389 0.000331 0.000329 0 0 0.003233 0 2.93E-07 0 2.09E-12 0.000174 0.000339 0.018653 0 0.015697 0 0 0.003668 1.47E-13 0.002588 0.000671

Wiley-Blackwell and Society for Applied Microbiology Page 325 of 848

Yersinia pseudotuberculosisCampylobacterErythrobacter jejuni strain strainThermus YPIII-01 litoralis RM1221-30 thermophilus strainEhrlichia HTCC2594-01 chaffeensisHaemophilus strain HB27-08 str.Candidatus Arkansas-30influenzae StreptococcusSulcia strain muelleri 86-028NP-01Bacillus pyogenes strain tusciae GWSS-08 MGAS8232-08 strain DSM 2912-08 0.002285 0 0.059134 0.007753 0 0 0 0 0.021249 0.000351 0 0.003373 0 0 0.002094 0.096919 0 0 0 0 0.004418 0 0 0.00141 0.019347 0 0 0 0 0.0142 0.00329 0 0.006515 0 0 6.01E-05 0 0 0.016791 0 0.029233 0 0 0 0.000128 0 0 0.012085 0.003253 0 0.008559 0 0 9.73E-15 0 0 0.027452 3.68E-06 0 0 0 0 0.00786 0.002157 0 0.010645 0 0 0 0 0 3.01E-06 0 For0 0.028753 Peer0.00299 Review0 0.002731 Only0 0 0 0 0 0.009024 0 0.10468 0.002533 0 1.01E-05 0.000909 0.001211 0 0.007939 0.000707 0 0 0 0 0 0.000752 0 0.027102 0 0 0.003801 0 0 0 0 0 0.014987 0.002645 0 0.017463 0 0 0.000472 0 0 0.0264 0 0.004286 0 0 0 0.000425 0 0.021442 0.016981 0 8.33E-06 0.003928 0.185197 0 0.009473 0 0 0.019162 0.00396 3.43E-14 0.001395 0 0 0.002886 0 0 0.022581 0.003875 4.36E-10 0.005366 0 0.001151 0.009002 0.000245 0 0.00233 0 0 0.000787 0.039065 0 3.53E-09 0 0 0.01792 0.000371 0.00034 0.008615 0 0 0.000115

Wiley-Blackwell and Society for Applied Microbiology Page 326 of 848

SalinosporaErythrobacter sp. CNB440-30Synechococcus litoralis strainMethanocaldococcus sp. HTCC2594-08 CC9605-01Bordetella sp.aviumDesulfovibrio FS406-22-08 strainListeria 197N-01 desulfuricans innocuaMethanobrevibacter strainsubsp. MinibacteriumClip11262-30 desulfuricans ruminantium strain massiliensis-01 ATCC strain 27774-08 M1-01 0 0.260133 1.08E-05 0.009183 0.007227 0.015247 0 6.37E-05 0.002759 0 0.060217 0.000601 0 3.08E-07 0 0 0 0.002876 0.004279 0.082177 0.000455 0 0.000983 0.001417 0 0 0.003647 0 0.068315 0 0 0.009345 0 0 0 0.007303 0 0.045179 0.000582 0 0.002344 0.000145 0 0 0.005783 0 0.069835 0.000225 0 0.001777 0.002055 0 5.85E-05 0.005988 8.16E-06 0.053965 2.05E-05 0 0.003079 0 0 0 0.008679 0 0.076371 0.000484 0 0.002357 0.008148 0 0.000262 0.006512 0.007401 0.058459For0.000471 Peer0 0.003528Review0.00101 Only0 0 0.0074 1.01E-15 0.057705 0.000319 0 0.002453 0.00239 0 0 0.006492 0 0.074172 0.00057 0 0.006258 0.002439 0 4.42E-05 0.006949 0 0.051759 0.000652 0 0.004755 0 0 0.00054 0.006457 0 0.070193 0.000952 0 0.005327 0.003968 0 0 0.008657 0 0.078197 0.015588 0 0.002681 0.000718 0 2.35E-05 0.0062 0.001241 0.143125 0.001499 0 0.003192 0.006835 0.000823 0.001767 0.007283 0.007221 0.057813 0.008038 0 0.001541 0 0 0 0.005047 0.001487 0.167485 0.000432 0 0.001136 0.008607 0 0 0.009458 0.000593 0.048763 8.09E-11 0 0.001041 0.000672 0 0 0.004104 0.008188 0.098655 0 0 0.005497 0.009053 0 0 0.005851

Wiley-Blackwell and Society for Applied Microbiology Page 327 of 848

PelodictyonNostoc luteolum sp. DSMstrainAlcanivorax 273-08 PCC 7120-30Bacillus borkumensis cereusbacterium strain strain SK2-01 Q1-01 Ellin345-30BurkholderiaPseudomonas cenocepaciaEhrlichia putidastrain ruminantium MC0-3-30GB-1-08Methanobrevibacter strain Welgevonden-30 ruminantium strain M1-30 0.045217 0 0.104937 3.56E-05 1.05E-08 0.000385 0.014641 0 1.53E-05 0.028028 0.031519 0.018781 0 0 0.007289 0.079579 0.135125 1.86E-08 0.012523 0.007712 0.041995 5.62E-12 0 0.000837 0.033481 0.000802 0 0.011704 0.000306 0.083602 0 0 0.001661 0.045385 0 4.05E-07 0.000936 0.011401 0.050677 0 7.36E-05 0.003016 0.019457 0 0 0.0102 0.034425 0.06698 1.37E-05 0 0 0.099389 0 0.000373 0.003136 0.025748 0.078612 0 0 0.003845 0.028757 0.030528 2.80E-07 0.001998 0.04305 0.078106 0 5.25E-12 0.069365 0.093436 0.114398 0 0.001582 0.011383For0.054025 Peer1.91E-05 Review0 0.00672 0.017941 Only 0 0 0.003972 0.09824 0.064433 1.04E-05 0.02437 0.000143 0.083687 0 1.47E-05 0.004415 0.030482 0.056043 8.31E-06 0 0.027577 0.09986 0.072567 0 0.022854 0.040622 0.081473 0 0 6.01E-13 0.05045 0 0 0.010402 0.060543 0.148906 0 5.51E-06 0.002454 0.139826 0 0 0.000709 0.036328 0.036347 7.94E-05 0 0 0.005853 0.018948 0.040737 0.02475 0.008383 0.048434 0.00015 0.013737 0.009867 0.039093 0 2.46E-07 0.009005 0.01558 0.029117 9.73E-05 0.000121 6.81E-05 0.024289 0.011983 0.003959 0.025276 0.012764 0.092619 1.12E-08 0.033851 0.006745 0.026014 0 0 0.00067 0.059135 0.017796 7.33E-05 0.001415 0.000134 0.027659 0 0.001367 0.005893 0.048947 0.14711 0 0 0.002704 0.109386 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 328 of 848

MycoplasmaProsthecochloris capricolumBradyrhizobium subsp. vibrioformis capricolumAcaryochloris japonicum DSM strainPseudomonas 265-08 marina ATCCstr. USDA 27343-08MBIC11017-08Aquifex fluorescens110-01 aeolicusRickettsia strain str. VF5-30 Pf0-1-30belliiSulfurihydrogenibium strain OSUHelicobacter 85-389-30 sp. acinonychis YO3AOP1-01 strain Sheeba-08 0 0.032605 0.009272 0.007219 0.035672 0 0 0.015389 0 0 0.047454 0.001734 0.012943 0.009165 0 0.329025 1.02E-05 0 2.51E-07 0.007916 0.001493 0.007194 0.015273 0 0 0.001535 0 0 0.007671 0.006538 0.008079 0.100607 0 0 0 0 0 0.005724 0.002873 0.007526 0.022486 0 4.17E-10 0.000169 0 0 0.009517 0.00311 0.00187 0.106979 0 0 0.001585 0 0 0.010668 0.00311 0.010483 0.017582 0 0 0.000332 0 1.64E-10 0.018293 0.002623 0.027714 0.079589 0 7.91E-17 2.93E-11 0 0 0.004843For0.002121 Peer0.00167 0.033139Review0 0.029978 Only0.001146 0.002952 0 0.004755 0.002049 0.00903 0.010104 0 0.00068 3.70E-09 0 0 0.006263 0.004468 0.008889 0.047839 0 0.064127 0.000309 0 0 0 0.004004 0.008563 0.038946 0 3.06E-18 0.000456 0 0 0.009837 0.003611 0.012174 0.043965 0 0.027528 3.09E-09 0 0 0.002509 0.002079 0.009206 0.000913 0 0 9.17E-05 0 0 0.035391 0.002569 0.008133 0.048065 0 0 0.001584 0 0 0.006747 0.00297 0.00872 0.039891 0 0.000434 0.001201 0.000484 0 0.020144 0.004172 0.009241 0.021689 0.000764 0.019977 0.000513 0 0 0.000663 0.002344 0.008048 0.027039 0 0 1.09E-05 0 1.04E-09 0 0.006889 0.004704 0.035132 0 0.012236 0.001384 0

Wiley-Blackwell and Society for Applied Microbiology Page 329 of 848

StreptococcusBrevibacillus suis strainNocardia brevis 98HAH33-30 strain farcinicaParacoccus NBRC strain 100599-01 Roseiflexusaminophilus IFM 10152-30Shigella castenholzii Urakami boydii etBrucella strain al. strain 1990;-01 DSM sp. Sb227-01Photorhabdus CCM 13941-01 4915-01Mannheimia luminescens succiniciproducens subsp. laumondii str. str. MBEL55E-30 TTO1-30 0 0.001007 0 0 0.01804 0 0.015385 0.239066 0 0 3.53E-06 0 0 0 0 0 0.165513 0 0 0.000104 0 0 3.33E-06 0 0 0.037255 0 0 0.000372 0.013048 0 2.24E-07 5.52E-05 0 0.004012 0 0 0.000529 0.001976 0 0.000139 0 0.00379 0.020752 0.01947 0 0.000732 0 0 0.000462 0 0 0.106285 0 0 0.000651 0 0 0.000102 0 0 0.022629 0 0 6.45E-05 0 0 0.000669 0 0.002782 0.173591 0.206201 0 0.00014For1.30E-05 Peer0 3.01E-05Review0 Only0 0.036349 0 0.058946 0.000484 0 0 4.65E-05 0 0 0.15594 0 8.34E-06 0.001403 0 0 0.000601 0 0 0.161938 0 0 0.001791 0 0 5.92E-08 0 0 0.034458 0 0 0.00066 0.011487 0 0.000695 0 0.0062 0.036683 0.081511 0 0.001429 0.000588 0 2.74E-08 0 0.013539 0.088342 0.010104 0 0.000929 0.001349 0 7.12E-05 0 0 0.007597 0.023634 0 0.000862 0 0 0.000105 1.51E-05 0.007499 0.135138 0 0 0.000625 0.011639 0 0.002147 0 0 0.015473 0.006369 0 0.000133 0 0 0 0 0 0.030958 0 0 0.000357 0.002674 0 0.000271 0.000526 0 0.046517 0

Wiley-Blackwell and Society for Applied Microbiology Page 330 of 848

MethanobrevibacterStaphylococcus smithiiThermosipho epidermis strainCyanothece ATCC africanus RP62A-08 35061-08Treponema strainsp. BH68K-01 TCF52B-08Xanthomonas denticola str.Citrobacter ATCCsp. Py2-01 35405-30 Chloroherpetonkoseri strainVibrio ATCC thalassium salmonicida BAA-895-08 strain LFI1238-08 ATCC 35110-30 1.67E-05 0 0.002639 0.007895 0 0.009834 0.018964 0.022772 0.005522 0 0 0 0.004154 0 0.002724 0.009779 0 0.074712 0 0 0.000236 0.002848 0 0.001124 0.000376 0 0.017475 0 0 1.05E-09 1.16E-08 0 0.002251 0.006372 1.45E-10 0.049152 0 0 1.18E-18 0.000972 0 0.007742 0.000559 0.013889 0.022918 0 0 0 0.003879 0 0.002359 0.016596 0.000951 0.035602 0 0 0 0.000768 0 0.005473 0.005029 0.066657 0.03062 0 0 0 0.001213 0 0.006209 0 0.149779 0.059289 0 0.000651For0.00052 Peer0.00081 0.013722Review0.006969 0.003168 Only0.023295 0.026765 0 3.84E-09 0 0.003097 3.63E-07 0.003823 0.013921 0.003077 0.040052 0 0 0.002531 0.000472 0 0.004425 0 0.066747 0.064672 0 0 0 0.000316 0.028789 0.002858 0.010719 0.077493 0.031278 0 0 0.003895 4.37E-05 0 0.007396 0.012143 0 0.111057 0.000284 0.000502 0 0.001389 0 0.010375 0 0 0.007022 0.001953 0.008142 0.003542 0.000234 0 0.003311 0 0.022577 0.026375 0 5.19E-06 0 0.000409 0 0.008644 0.003351 0.012128 0.00968 1.92E-06 0.000151 0 0.001559 0.016086 0.004134 0 0.054118 0.025049 0 0 0 7.98E-05 0 0.001373 0 0.044651 0.025398 0 0 0 0.0001 0 0.004699 0 0.032145 0.082562

Wiley-Blackwell and Society for Applied Microbiology Page 331 of 848

RhodopirellulaYersinia baltica pseudotuberculosis strainDesulfotalea SH 1-30Mycobacterium psychrophila strainHaliangium IP 31758-30LSv54-30 sp. JLS-01Burkholderia ochraceumRickettsia strain sp. 383-30 DSM massiliaeNitrosomonas 14365-08 strainThermomonospora eutrophaMTU5-30 strain C91-01curvata strain DSM 43183-08 0.475261 0 0.061504 4.10E-05 0.041669 0 0 0.012934 0.034089 0 0 0.111852 3.76E-06 0.000201 0.061723 0 0.003703 0 0.038081 0.007383 0 0.000257 0.001616 0.009639 0 0.00652 0.004234 0.03311 0.058771 0.039567 0 0.001848 0.017031 0 0.005372 0 0.004666 0.001171 0.005942 0.000346 0.002486 0.007147 0 0.006649 0.000131 0.004888 0 0.009616 0.000284 0.004316 0.086682 0 0.012044 3.25E-06 0.234884 0 0.082132 0.000249 0.00219 0.005855 0 0.044271 0.009866 0.218479 0 0 0.000239 0.00321 0.069502 0 0.008005 0.000333 0.051758 0.000358For0.031709 Peer0.000357 0.001333Review0.005389 Only0 0.006608 2.61E-05 0.044404 0 0 0.000517 0.003706 0.000322 0 0.004577 0.000568 0.090432 0.007984 0.053293 0.000659 0.002773 0.028594 0 0.011122 0.001843 0.034464 0.005132 0.023177 0.000257 2.82E-05 0.000222 0 0.003313 5.15E-05 0.027912 0.018945 0 0.001072 0.008075 0.000241 0.000559 0.012782 0.001412 0.040596 0 0 0.000166 2.39E-10 0.023873 0 0.005295 0.002554 0.410976 0 0.231089 5.95E-05 0.028385 0.019242 0 0.062203 0.016485 0.269495 0.007362 0.045885 0.000384 0.001355 0.004377 0 0.004224 0.002106 0.291155 0 0.090368 6.67E-05 0.012986 0.005171 0 0.057226 0.013575 0.024983 0 3.47E-06 0.000177 0.003175 9.45E-07 0 0.003692 0.000504 0.033805 0.004569 0.065126 0.000174 0.002703 0.001101 0.025174 0.006223 0.000687

Wiley-Blackwell and Society for Applied Microbiology Page 332 of 848

AciduliprofundumStreptomyces booneiOrientia coelicolor strain tsutsugamushi T469-08Rhodobacter A3(2)-30 methanogenic strain sphaeroides Ikeda-01Synechococcus archaeonstrain 2.4.1-30Salinispora strain sp. CC9902-08 SANAE-01 sulfate-reducingarenicola strainRhizobium CNS-205-30bacterium etli strain Hxd3-30 CFN 42-30 0.12753 0.001597 2.42E-09 0.050375 0.001997 0.033852 0 0.033426 0.006278 0 0 0.001127 0.024516 0 0.004158 0 0.006899 0 0.007198 0 0.000354 0.107167 0 0.073382 0.002953 0.024149 0.012246 0 0 0.001547 0.473122 0 0.006188 0 0.000186 0.005607 0 0 0 0.315851 0 0.012227 0 0.000139 0.021611 0 0 0 0.108669 0 0.001131 0.008862 0 0 0.015684 0.003282 1.88E-06 0.03959 0.000158 0.012288 4.48E-18 0.018052 0.003887 0 0.000156 5.84E-08 0.18179 0 0.003804 0.000234 0 0 0 For0 1.42E-08 Peer0.101573 Review0 1.999654 Only0 4.84E-06 0.004494 0 1.41E-15 0.001152 0.096401 0 0.001359 8.07E-16 0.022715 1.69E-05 0 0 0.000722 0.14233 1.41E-08 0.002643 3.34E-05 0 0.038505 0 0 0.002505 0.045341 0.000948 0.099499 0 0 0.004735 0 0.00016 0 0.083116 0.000203 0.003118 0 0 0.025269 0.011982 0 0.000397 0.030185 0.000483 29.85248 0 0.01407 0.001974 0.009849 0.003161 6.70E-05 0.058976 0.00034 0.011109 0.001374 0.052054 0.003545 0.014592 0.006899 0.000886 0.053595 0 26.98372 0 1.22E-05 0.00726 0.015435 0.000597 0.001132 0.04355 0.000717 0.000113 0.002404 0.046986 0.013323 0 1.16E-05 0.000278 0.168078 0 0.002693 0.002891 0 0.009326 0 0 0.000473 0.091197 0 0.004176 0 0 0.011697

Wiley-Blackwell and Society for Applied Microbiology Page 333 of 848

Thermotogabacterium sp. RQ2-01 CBDB1-08Bacillus cereusBifidobacterium strain E33L-08Rhodoferax longumSalinispora ferrireducens str. NCC2705-30 Sulfolobusarenicola strain T118-01strain acidocaldariusRickettsia CNS-205-01 canadensisGeobacter NCIB 11770-01 strainmetallireducens McKiel-08 strain GS-15-08 0.000313 0.099123 0 0 0.023337 0.001651 2.30E-31 0.004382 0.04629 0 0 0 0 0.002232 0 0 0 0.002368 0 0.009014 0 0 0.002093 3.88E-05 0 0 0.008294 0 0 0 0 0.001998 2.69E-05 0 0 0.000643 0 0 0 0 0.002132 0.000615 0 4.76E-06 0.000394 0 0 0 0 0.003848 1.88E-05 0 0 0.001399 0 0 0 0 0.008104 5.07E-05 0 0 0.004638 0.000648 0 0 0 0.010484 0.000173 0 0 0.002849 0 For0 Peer0 0 0.002167Review2.29E-05 Only0 0.020048 0.000238 3.71E-09 0 0 0 0.001349 0 0 0 0.004286 5.71E-08 0 0 0.062685 0.006042 0.00027 0 0.019444 0.00095 0 0 0 0 0.002596 1.46E-05 0 0 0.012332 0 0 0 0 0.005786 0.000148 0 0 0.001889 0 0 0 0 0.001216 0.000212 0 0 0.001051 0 0 0.000816 0 0.004564 0.000957 5.50E-09 0.028049 0.031791 0 0 0 0.002506 0.000561 0.000124 0 0.001371 0.00471 0 0 0 0 0.00709 0.000694 0 0.011067 0.015346 0 0 0 0 0.001283 5.65E-06 0 2.07E-17 0.000329 1.93E-08 0 0 0 0.005336 0 0 0 0.007245

Wiley-Blackwell and Society for Applied Microbiology Page 334 of 848

Bartonella bacilliformisStreptococcusStreptomyces strain suis KC583-30strainActinobacillus 98HAH33-01griseus subsp.Thiomicrospira succinogenes griseusPectobacterium strain denitrificans strain NBRCCandidatus 130Z-08 13350-01 carotovorum ATCC Arthrobacter33889-30Azobacteroides subsp.Burkholderia sp. carotovorum pseudotrichonymphaeFB24-30 cenocepacia strain PC1-01 HI2424-08 genomovar. CFP2-08 0 0 0.002677 0.013467 0 6.91E-06 0 0 7.40E-05 0 0 5.96E-06 0 0 0.000189 0.025241 0 0.005181 0.000199 0 4.07E-16 0.01767 0 0.001063 0 6.39E-05 0.001544 0.043119 0 0.001878 0 0.001281 0.001881 0 0.019311 0.003078 0 0 0.000152 0.017173 0 0.001345 0 0.00447 0.003446 0 0 9.87E-05 0 0.170337 0 0 0 0.005148 0 0 0.000744 0 0.003508 0.001277 1.02E-11 3.37E-07 0.001884 0 0 0.000127 0.039643 0 0.002663 0 0 0.007996 0 For0 6.40E-05 Peer0.014832 Review0 0.001968 Only0 0 0.000766 2.57E-18 0.001368 0.000229 0 0 0.001371 0.015795 0 0.002027 0 0 0.000115 0.031589 0 0.001755 0.008467 0 0.003888 0 0 0.00019 0 0.009244 0.001298 0 0.016143 0.001975 0 0 6.56E-06 0.04588 0 0.004021 0 0 0.002885 0 0 6.00E-05 0 0 0.000662 0.026697 0 0.000618 0.029792 0 0.001029 0.005798 0.069404 0.001143 0.019916 0 0.003362 0.029879 0 7.88E-06 0.00376 0.024452 0.000309 0.001299 0 0.002026 0 0.000161 0.000218 0.024205 0.010095 0.001662 0.019071 0.004955 0 0 0 7.16E-06 0 0 0 0.00432 1.48E-05 0.000627 0.01278 0 2.30E-05 0.062916 0 0.001929 0.028245 8.23E-09 0.010492

Wiley-Blackwell and Society for Applied Microbiology Page 335 of 848

SynechococcusOligotropha sp. PCC6301-30Francisella carboxidovorans tularensisLactococcus strain subsp.Pseudomonas lactis OM5-30 holarctica subsp.Rubrivivax lactis syringae strain strain gelatinosusStaphylococcusFTNF002-00-01 pv. KF147-01 phaseolicola ShigellaPM1-30 haemolyticus strain flexneriPyrobaculum 1448A-01 serotype strain JCSC1435-30aerophilum 2a str. 301-30 strain IM2-08 0 0.259191 0.001257 0 0.003933 0.086733 0 0 0 0 0.02131 0 0 0.001743 0.178962 0 0 0 0.143063 0.011303 0 0 0.004508 0.017988 0 0 0 0 0.052858 0 0 0.010778 0.000524 0 0 0 0.095136 0.010532 0 0 0.006168 0.015225 0 0 0 0 0 0 0.000545 0.009781 0.245611 0 0 0 0 0.028125 0 2.89E-08 0.007916 0.081616 0 0 0 0.376605 0.127564 0 0 0.010993 0.637377 0 0 0 0.049828 0.003656For Peer0 0 0.003119Review0.031421 Only0 0 0 0.428631 0.008218 0 0 0.005151 0.134916 0 0 0 0 2.79E-09 0 0 0.006961 0.14202 0 2.37E-05 0 0 1.28E-09 0 0.000521 0.005941 0.0359 0 0 0 0.373383 3.33E-08 0 0.000337 0.024959 0.107435 0 0 0 0.138542 0.00169 0 0 0.001975 0.071705 0 0 0 0.012694 0.025901 0 0.001633 0.005217 0.049597 0 0 0 0.04842 0.030048 0 0 0.002803 0.05839 0.001759 0 0 0 0.034577 0 0 0.006609 0.044441 0.00855 0.00698 3.81E-07 0.264803 0.001461 0 0 0.001428 0.000334 0 0 0 0 0.006651 0 0 0.021619 0.060007 0.03091 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 336 of 848

MycoplasmaEubacterium arthritidisBacillus strain eligens 158L3-1-01 megaterium strainXanthomonas ATCC strain 27750-30Flavobacterium campestris DSM319-01Shewanella pv. psychrophilum campestrisMycoplasma putrefaciens str. strain ATCCCampylobacter capricolum strain JIP02/86-01 33913-01 CN-32-30Pseudomonas subsp. concisus capricolum strain aeruginosa 13826-01 strain strain ATCC LESB58-30 27343-01 0 0 0.000384 0.002245 0.079425 0 0 0.004195 0.062092 0 0 1.55E-06 0.000422 0.170464 0.013036 1.85E-09 0.001809 0.014099 0 0 0.000362 0.000996 0.188484 0 1.28E-07 0.001087 0.016216 0 0 0 0.000259 0.372639 0.062326 0 4.87E-06 0.157336 0 0.002586 0.000864 0.000998 0.201924 0.037969 0 0 0.025944 0 0 0.000384 0.001131 0.580435 0 0 2.68E-05 0.084567 0 0 0.001075 0.002205 0.177594 0 1.04E-06 0 0.023575 0 0 4.75E-07 0.001506 0.7517 0 8.65E-07 1.57E-10 0.032608 0.000656 For0 0.000655 Peer0.000726 0.119256Review0 Only0 1.12E-05 0.029996 0 0 0.000367 0.000429 0.308033 0 8.68E-08 0.001384 0.044434 0 5.68E-10 0.000556 0.002045 0.348941 0 0.002908 0.000315 0.073217 0 0 0.000229 0.000587 0.299092 0.382751 0 1.63E-05 0.097346 0 0 0.000295 0.001918 0.743885 0.000321 2.35E-05 0 0.033642 0 0.005551 0.000174 0.00106 0.156804 0 0 0.000429 0.007603 0 0 0.000857 0.001915 0.158664 0 2.19E-07 0.002699 0.056467 0 0 7.17E-05 0 0.065142 0.066027 0 2.14E-05 0.056071 0 0.003579 0.001303 0.002435 0.241727 0 0 0.000319 0.013924 0 0 1.13E-07 0.000338 0.171147 0 0 3.23E-06 0.049505 0 0 0.000389 0.001678 0.690997 0 0.001022 0.000224 0.060097

Wiley-Blackwell and Society for Applied Microbiology Page 337 of 848

BurkholderiaGeobacillus glumae strainRhodobacter sp. Y412MC61-08 BGR1-01Prochlorococcus sphaeroidesStreptococcus strain sp. NATL2A-08 KD131-30Methanocaldococcus pneumoniaeSalinibacter strain sp. AcidimicrobiumTaiwan19F-14-01 ruber FS406-22-01 strainBurkholderia DSM ferrooxidans 13855-08 glumae strain strain DSM BGR1-08 10331-01 0.002884 0 1.72E-08 0.005474 0 0.003293 0.017296 0.244363 0.008933 0.00012 2.27E-12 0.022259 7.93E-05 0 0 0 0 0.005031 0.000324 0 0.098827 0.008239 0 9.68E-05 0.000203 0.000159 0.000521 0.001723 0 0.404659 0.008828 0 0 1.43E-12 0 0.009214 0.000948 0 0.273953 0.016794 0 0 0.001351 0 0.007299 0.001871 0.002212 0.0871 0.003316 0 0 0.001535 0 0.00243 0.001132 0 0.04047 0.017628 0 0 0.002321 0.02964 0.001468 0.001921 0 0.065458 0 0 0 0 0.00255 0.005217 0.000914 For0 0.09606 Peer0.007907 Review0 0 0.002081 Only0.000951 0.000977 0.000685 0 0.102692 0.015201 0 0 1.10E-05 0 0.002585 0.000852 0 0.153949 0 0 0 0.000858 0.001275 0.006429 0.000832 0 0.036243 8.77E-06 0 0 0 0.000927 0.017497 0.002582 0 0.051174 0.003964 0 0 0.000437 0.000591 0.016515 0.000373 0.001453 0.028438 0.012909 0 0 0.000281 0.016541 8.27E-06 0.000464 0.009289 0.070789 4.79E-05 0 0.001161 0.008101 0.004091 0.004663 0.000563 0 0.049886 0.041903 0 0 0.001675 0.010866 0.001168 0.001996 0 0.038473 0.00535 0 0 0.004071 0.009181 0.008222 0.000515 0 0.170475 0.000162 0.000846 0 0 0 0.006493 0.002714 0 0.094005 0.008255 0 0 0.001644 0 0.004758

Wiley-Blackwell and Society for Applied Microbiology Page 338 of 848

Seattle AquariumThioalkalivibrio strainAggregatibacter SCM1-30 sp. K90mix-01Mycobacterium aphrophilusParacoccus abscessus strain Salmonelladenitrificans NJ8700-01 strain ATCC Cryptobacteriumenterica PD1222-01 19977-30 subsp.Streptococcus enterica curtumVibrio serovarstrain suis cholerae strain DSM Schwarzengrund SC84-3015641-01 serotype O1 strain biotype CVM19633-08 ElTor strain N16961-01 22.74234 0.05143 0.000893 1.38E-05 0.024324 0 0.00693 0 0 0 0.004064 0.000169 0.053579 0.010378 0 0 0 0 0 0.010192 0.000333 0.000252 0.013169 0 0 0 5.77E-05 0 0.014724 0 0.000385 0.055993 0 0 0 0 0 0.009883 0.003255 0.017983 0.035684 0 0 0 0.004393 0 0.030081 0 0.14733 0.025033 0 0.001801 0 0.001023 11.63534 0.039959 0 0.018167 0.031082 0 0.000434 0 0 0 0.026157 0.002804 0 0.025631 0 0 0 0 0.023316 0.01938For0.001364 Peer0.007536 0.033764Review0 Only0 0 0.003257 0.299357 0.027965 0 0.064287 0.02053 3.53E-05 0 0 0.010021 0.133614 0.021209 0.003559 0.086312 0.020676 0.006057 0.005215 0 0 0 0.014036 0 0 0.052413 0 0 0 0.006767 0.035844 0.054274 0.007225 0.040302 0.058238 0 0 0 0 0.03373 0.014456 0.004097 0 0.024953 0 0 0 0 16.57195 0.027688 0 0.016081 0.02188 0 0.002109 0 0.000873 0 0.011279 0.001889 0 0.027414 0.00089 0 0.115986 0 13.98883 0.034203 0.005642 0.004634 0.021095 0 0.000226 0 0 0 0.006232 0.000805 0 0.021994 0 0 0 0.002013 0 0.05253 0.004723 0.004472 0.068484 0 0 0 0.016452

Wiley-Blackwell and Society for Applied Microbiology Page 339 of 848

HaliangiumPyrobaculum ochraceumVibrio strain calidifontis parahaemolyticus DSMLegionella 14365-30 strain JCM pneumophilaAcidiphilum 11548-30str. RIMDXanthomonas 2210633-30cryptum str. Paris-30 JF-5-08Sphingomonas sp. Py2-08Helicobacter sp. KA1-01Ochrobactrum mustelae strain anthropi 12198-08 strain ATCC 49188-01 0.142855 0 0.082153 0 0.081897 0.039016 0.236822 0 0.01388 0 0 0.427903 0 0.010917 0.006056 0 0 0.002103 0.00791 0 0.015947 0 0.032728 0.017882 0 0 0.001962 0.042334 0 0.032736 0.005306 0.019212 0.022179 0 0 0.013414 3.34E-05 0 0 0 0.019126 0.020361 0 0 0.005296 0.044441 0.098017 0.004698 0 0.006974 0.031687 0 0 0.008031 0.017036 0 0.048843 0 0.043951 0.029557 0 2.40E-05 0.00712 0.014111 0 0.185522 2.00E-05 0.016968 0.030309 0 0 0.010127 0.024599 For0 0.034159 Peer0 0.012949Review0.010504 Only0 0 0.006161 0.027851 0 0.157143 0.006955 0.008173 0.021214 0 7.56E-06 0.002665 0.023271 0 0.150041 0.072944 0.012986 0.018425 0 0 0.006152 0.001005 0 0.029769 0 0.009645 0.010859 0 0 0.012641 0 0 0.059964 0.008734 0.01655 0.033559 0 0 0.010042 0.012644 0 0.037921 2.30E-05 0.012667 0.007047 0 0 0.006968 0.093663 0.013847 0.032019 0 0.051168 0.018848 0 6.37E-12 0.00676 0.000467 0 0.03644 0 0.015812 0.008656 0 0 0.00443 0.016946 0 0.025434 0 0.072939 0.025722 0 0 0.008571 0.009397 0 0.138014 0.010618 0.013105 0.019596 0 0 0.008546 0.010137 0 0.0483 0 0.01341 0.020563 0 0 0.00816

Wiley-Blackwell and Society for Applied Microbiology Page 340 of 848

MycobacteriumMethanosarcina smegmatisGeobacillus strainacetivorans ThermomicrobiumMC2 thermodenitrificans 155-01 str. C2A-01Lactococcus roseum strainPhytoplasma lactis DSMNG80-2-08 subsp. 5159-01Wolbachia solanilactis strainaustralensis-08 sp.Rhodothermus Il1403-01wRi-30 Leptospira marinus borgpetersenii strain DSM 4252-01 serovar Hardjo-bovis strain JB197-08 0.003084 3.05E-05 0.018882 0.044352 0 0 0 0.095293 0 5.64E-07 1.50E-14 1.76E-11 6.41E-06 0 0 0 0.003376 0 0.000527 6.21E-06 0 0 0 0 2.81E-05 0.004717 0.000254 1.66E-18 8.32E-05 0 0 0 0 4.17E-09 2.08E-07 8.88E-05 6.92E-05 8.24E-07 6.48E-06 0.000118 6.02E-06 0 6.80E-07 0.002913 0 1.63E-05 4.79E-08 0.005772 0.000306 0 0 0 0.00868 0 5.33E-05 6.34E-05 0.007066 0.002414 0 0 0 0.020081 0.008038 0.000932 5.20E-08 0 0.001923 0 0 0 0.019712 0 9.19E-05 2.09E-05For Peer0 1.30E-06 Review0 0 0.014116 Only0.00117 0 1.74E-05 1.18E-05 0.002396 0.000979 0 0.001079 0 0.013908 0 0.000175 0.000147 0.00819 0.000982 0.000343 0 0 0.005164 0 0.000601 2.91E-05 0 0.000418 0 0 1.71E-18 0.001673 0 0.000786 2.48E-09 0.000299 0.000443 0.000419 0 0 0.008372 0.000872 0.000448 7.77E-06 0 5.99E-13 0 0 0.060108 0.000877 0.002035 0.000193 0.000437 0 0.002742 0 0 1.06E-06 0.018219 0.007879 9.37E-05 0.000422 0.000698 4.76E-07 0 0 1.36E-20 0.001833 0.001483 3.29E-06 0.00058 0.007905 0.001316 0 0 0.001975 0.020265 0 0.000628 1.57E-07 0 0 0 0 0 0.001362 0 0.000515 3.17E-05 0.007286 0 0 0 0.000113 0.00627 0

Wiley-Blackwell and Society for Applied Microbiology Page 341 of 848

BdellovibrioXenorhabdus bacteriovorusCoxiella bovienii strain burnetii HD100-08strainAcinetobacter strainSS-2004-08Shigella CbuK_Q154-01 baumannii flexneriGeobacter strain 5 strain SDF-01 uraniumreducensClostridium 8401-30 Xanthomonas kluyveri Rf4-30 strainStreptococcus sp. NBRC Py2-30 12016-01 agalactiae str. A909-30 0.04073 0.013992 0 0.002722 0 0.003861 0.002551 0.048327 0 0.010989 0.032555 0.004633 0.005923 0 0.079694 0 0.00195 0 0.005657 0.003521 0 0.011461 0 0.000629 0 0.001973 0 0.009286 0 0 0.004908 0 0 0 0.009482 0 0.001295 0.007565 0 0.001994 0 0.02166 0 0.01024 0 0.005239 0.025742 0 0.009582 0 0 0 0.196871 0 0.007781 0.012029 0.028251 0.005581 0 0.058159 0 0.028338 0 1.08E-13 0.032789 0.009952 0.004604 0 0.176186 2.94E-07 0.027167 0 0.005769 0.001525For0.006184 Peer0.004111 Review0 0.002812 Only0 0.010277 0 0.008317 0.028228 0.007134 0.008796 0 1.94E-09 0 1.02E-08 0 0.005869 0.015577 0 0.003279 0 4.17E-19 6.75E-05 0.015033 0 0.003857 0 0 0.005932 0 2.15E-06 0 2.05E-05 0 0.00389 0.03561 0 0.010023 0 0.003524 0 2.38E-05 0 0.000178 0.001678 0 0.002933 0 0.002021 2.71E-05 0.001689 0.004686 0.039831 0.002727 0.009552 0.003957 0 0.031326 0 0.031733 0 0.005913 0.002029 0 0.002885 0.000252 0.007873 0 0.008486 0 0.013445 0.01459 0 0.006175 0 0.033208 0 0.023178 0 0.0005 0 0 0.001249 0 0.006292 0 0.004698 0 3.35E-06 0.027308 0 0.008658 0 0 0 0.014998 0

Wiley-Blackwell and Society for Applied Microbiology Page 342 of 848

unidentifiedSinorhizobium eubacterium-01Chloroflexus melilotiBurkholderia strain sp. Y-400-fl-01 1021-01Borrelia mallei afzeliistrainKribbella strainNCTC flavida10247-01PKo-30Helicobacter strain MethanococcusDSM acinonychis 17836-30Granulobacter strain maripaludis Sheeba-01 bethesdensis strain C5-30 CGDNIH1-01 0 0.012569 0 0.000617 0 1.10E-11 1.46E-05 0 0.037611 0 0.004164 0 0.000157 0 0 0.000211 0 0.002649 0 0.007581 0.000695 0.00053 0 0.009934 0 0 0.005768 0 0.011527 0 0 0 0 0 0 0.000923 0 0.006485 0.000299 0 0 0 1.11E-07 0 0.01127 0 0.012773 0.000305 0.000572 0 4.56E-07 4.64E-15 0 0.003343 0 0.010828 0.001576 0 0 2.12E-06 0 0 0.024999 0 0.002528 0.001031 0 0 1.63E-24 0.000383 0 0.006284 0.011658 0.010136For Peer0 0.000275 0.017844Review0.004112 1.77E-05 Only 0 0.013451 0 0.00669 0.000259 0.000351 0 0 1.55E-15 0 0.001735 0 0.008496 0 8.31E-06 0 0 7.89E-11 0 0.009274 0 0.009019 0 0.000168 0 0.010799 8.41E-10 0 0.013928 0 0.011409 0.000313 0.002029 0 0 0.001286 0 0.006131 0 0.01021 0.000689 0.000136 0 0 5.62E-10 0 0.019969 0 0.009419 0.001865 0 0 0.001667 0 0 0.017506 0 0.00687 0.000229 1.15E-05 0 0.005803 0 0 0.014103 0 0.006947 0 0 0 0.009293 5.02E-05 3.43E-08 0.013001 0 0.005121 1.06E-07 5.94E-05 0 0 1.31E-06 0 0.00344 0 0.013737 0.000567 0.000843 0 0.003264 0.000188 0.001518 0.006694

Wiley-Blackwell and Society for Applied Microbiology Page 343 of 848

StreptococcusBacillus pneumoniae cereusMethylobacterium strain str. R6-01 ATCCBordetella 10987-01 radiotolerans petriiHydrogenobaculum strain strainLactobacillus DSM JCM12804-08 sp. 2831-08Streptococcus Y04AAS1-30 johnsoniiKytococcus strain thermophilus FI9785-08 Rhodobactersedentarius strain LMD-9-08strain sphaeroides DSM 20547-30 strain ATCC 17029-08 0 1.83E-05 0.034431 0.060327 0 0.010389 0 0 0.047955 0 7.10E-11 0.013875 0.01902 0 0 0.018694 0.041511 0.138454 0 5.77E-12 0.016619 0.007385 0 0 0 0.01729 0.34188 0 0 0.013029 0.014299 0 0 0 0 0.427018 0 0 0.011634 0.010905 0 0 0 0 0.330152 0 1.28E-08 0.008855 0.019104 0 0 0 0 0.217477 0 1.91E-06 0.019447 0.027273 0 0 0 0 0.140394 0 0 0.037843 0.020916 0 0 0 0 0.163607 0 For0 0.010972 Peer0.008579 Review0 0 Only0 0.013774 0.136057 0 1.07E-05 0.009753 0.008196 0 0 0.001269 0 0.140274 0 1.44E-15 0.012116 0.026153 0 0 0.005284 0 0.133321 0 0 0.02317 0.02032 0 0 0 0 0.334982 0 0 0.01418 0.025243 0 0 0 0 0.269929 7.59E-05 0 0.003016 0.012363 0 0 0 0 0.056501 0 9.59E-18 0.025432 0.034001 0.005811 0 0 0 0.173058 0 0 0.006139 0.003928 0.001244 2.98E-07 0 0.000252 0.097709 0 0.00011 0.008022 0.012 0.016539 0.002492 0 0 0.119626 0 2.71E-07 0.007769 0.009172 0 0 0 0 0.275374 0 0 0.010727 0.013439 0 0 0 0 0.326225

Wiley-Blackwell and Society for Applied Microbiology Page 344 of 848

Coxiella burnetiiBurkholderia strainAcaryochloris Dugway pseudomallei 5J108-111-30Xanthomonas marina strain MBIC11017-30 1710b-01Sulfolobus albilineans islandicusHistophilus var. paspali-01 strain Candidatussomni Y.N.15.51-01 str. 2336-01 ShewanellaLiberibacterShewanella amazonensis asiaticus strain woodyi strain psy62-30 strainSB2B-01 ATCC 51908-30 0 0.000164 0.03307 0.007811 6.66E-13 0.001449 0 0.003587 0.008207 0 9.25E-05 0.369748 0.001466 0 0.001298 0 0.004813 0 0.001306 0.000197 0.037826 0.00413 0 0.001187 0 0.01064 0.02023 0 0.000491 0.002815 2.28E-09 0 0.001489 0 0.017505 0.155208 0.004006 0.000552 0.021043 0.000539 0 0 0 0.008337 0.01806 0 0.000322 0.193964 0.00178 0 0.010672 0 0.025448 0.089045 0 0.000734 0.050694 0.003478 3.01E-07 0 0 0.013258 0.101128 0 0.00029 0.284911 0.003468 0 0.00729 0 0.023515 0.003068 0.062135 0.000188For0.025423 Peer0.001194 1.54E-12Review0.001721 0.029254 Only0.007293 0.055196 0 0.000273 0.08549 0.001796 0 0 0 0.015195 0.052861 0 0.000218 0.057168 0.005377 0 0.002337 0 0.016296 0.033637 0 7.31E-05 0.032605 0.00091 0 0.003014 0 0.010065 0.189235 0 0.000815 0.148379 0.009451 0 0.011755 0 0.036048 0.051198 0 4.51E-09 0.037891 0.002569 0 0.001751 0 0.00456 0.014989 0 0.000162 0.026144 0.004315 0 0 0 0.010618 0.058219 0.036032 0 0.0109 0.001106 0 0.00148 0 0.001285 0.069919 0 0.000788 0.011017 0.007281 0 0 0 0.018181 0.035575 0 4.61E-05 0.053181 0.002494 0 0.00037 0 0.00451 0.122379 6.87E-07 0.000814 0.070022 0.002599 0 0.009054 0 0.034236 0.073721

Wiley-Blackwell and Society for Applied Microbiology Page 345 of 848

PediococcusMethanococcus pentosaceusSalmonella strain maripaludis ATCC Burkholderiaenterica 25745-01 strain subsp.Pelodictyon S2-01 pseudomallei arizonaeClostridium phaeoclathratiforme serovar strain 62:z4;z23:---01 1106a-30Brachyspira perfringens strainOrientia hyodysenteriae str. 13-01 BU-1-30 tsutsugamushiPolaromonas strain WA1-01 strain sp. JS666-30 Boryong-08 0 0 0 0 0 0.001303 0.002462 0.018945 0.35346 0 0 0 0.143654 0 1.91E-06 0.001251 0 0.003983 0 0 0 0.008421 0 0 0 1.10E-05 0.019679 8.33E-10 0 0 0.019043 0 9.46E-08 0 0 0.003751 0 0 0 0.012261 0.009514 4.72E-05 0.001368 0 0.024214 9.86E-08 0 0 0.027849 0 0.000403 0.000964 0.009318 0.001247 0 0 0 0.014396 0 0.000545 9.01E-10 0 0.005473 0 0 0 0.077617 0 0 0 0.011749 1.37E-06 0 For0 Peer0 0.004558 0.002042Review7.37E-07 0.000694 Only 0 0.005815 0 0 0 0.073566 0 9.89E-05 0 2.75E-11 0.000634 0 3.07E-05 0 0.051779 0 2.72E-06 0.000685 0 0.037268 0 0 0 0.045741 0.002267 0.000161 0.000102 0 0.000433 0 0 0 0.005343 0.000295 0.000907 8.38E-06 0 0.001225 0.000272 0 0 0.015673 0 1.26E-05 0.000412 0.006769 0.001403 0.001592 0.000299 0 0.012864 0.006872 0.000902 0.00495 0 0.042453 0 0 0 0.006043 0 7.73E-05 1.63E-05 0 0.001289 0 0.001535 0 0.005918 0.0578 0.000136 0 3.30E-08 0.01486 0.000382 0 0 0 0.003373 0 0.000114 2.49E-11 0.038578 0 0 0 0.037554 0.004 3.12E-05 0 6.64E-10 0.002404

Wiley-Blackwell and Society for Applied Microbiology Page 346 of 848

VerrucomicrobialesCaulobacter str.Eubacterium sp.PB90-1-30 K31-08Acinetobacter eligens strainBeijerinckia baumannii ATCC 27750-08Methanoculleus indica strain subsp. ATCCRoseiflexus indica 17978-30 marisnigri strainMycobacterium sp. strain ATCCstrain RS-1-019039-01 JR1-08Corynebacterium smegmatis strain urealyticum MC2 155-08 strain DSM 7109-30 0.126606 0.01596 0 0 0.011095 0.049819 0.016443 0.001977 0 4.54E-05 0.005933 0 0 0.00434 0 2.12E-20 0.004987 0 0 0.009729 0 0 0.001796 0 2.05E-05 0.000128 0 0.029455 0.002412 0 0 0.002954 0 3.49E-06 0.001619 0 0.015475 0.004995 0.000561 0.022682 0.004276 0 1.06E-08 0.001335 0 0.000849 0.001905 2.78E-10 0.016502 0.003534 0 0.001236 5.40E-05 0 0.030993 0.011041 1.86E-05 0.032915 0.005985 6.55E-10 0.000635 1.51E-06 0 2.09E-06 0.002327 0 0 0.001612 0 4.32E-05 0.003646 0 0.015993 0.009442For4.51E-09 Peer0.028278 0.006242Review0 1.06E-05 Only6.02E-05 0.007256 0.020668 0.005298 4.16E-05 0.017951 0.003204 0 0.001008 0.00011 0 0.024125 0.005609 0.013915 0 0.005584 0 0.000502 0.00077 0 0.00564 0.004018 0 0 0.006414 0 2.58E-08 1.39E-09 0 0.030787 0.015059 0.002408 0 0.003403 0 1.23E-07 0.000444 0 0.034295 0.00094 0.000524 0.010265 0.00933 7.28E-07 7.12E-07 0 0 0.093419 0.008003 0 0.025871 0.003504 0.008706 0.000206 0.000914 0 0.06958 0.004987 0 0 0.008524 0.001273 0.000376 7.48E-05 0.015294 0.079283 0.017181 0.003081 0.004746 0.00608 4.99E-05 0.000539 0.00202 3.57E-05 0.049471 0.002519 0 0 0.001829 0 0.000113 0.000352 0 0.013997 0.008043 0 0 0.003988 0 0.000318 0.001069 0

Wiley-Blackwell and Society for Applied Microbiology Page 347 of 848

MycobacteriumSchizoplasma tuberculosisAggregatibacter hominis-01 strainBacillus H37Ra-01 actinomycetemcomitans haloduransOrientia straintsutsugamushinot C-125-30Oenococcus strainEscherichia strain D11S-1-01 oeni Boryong-30 MCW-30 Micrococcuscoli strain BW2952-01Vibrio luteus cholerae strain NCTC serotype 2665-08 O1 biotype ElTor strain N16961-08 0.000811 0 0.001057 0 0 0 0 0.000737 0.024011 0.000122 0 0.002706 0 0 0 0 0 0.097496 0 0 0.002497 0 1.08E-19 0 0 0 0 0 0 0.005454 0 0 0 0 0.001136 0 0 0 0.002559 0.000723 0 0 0 0.00502 0 0 0 0.0081 0 0 0 0 0.000803 0 0 0 0.004732 0.00269 6.69E-33 0 0 0 0 0 2.99E-09 0.004351 0 0 0 0 0 0.0572 0 For0 0.002168 Peer0.00224 0.006315Review0 Only0 0 0.00988 0 0 0.003372 0 0 0 0 1.20E-06 0 0 0 0.002963 0 0 0 0.001207 5.69E-07 0.053309 0 0 0.005598 0.000759 0 0 0 0 0 0 0 0.011175 0.000943 0 0 0 0.002177 0 0 0 0 0 0.003084 0 0 0 0 0 0.000625 0.002965 0.009887 5.45E-10 0 0 0 0 0 0 0.001801 0.000182 0.017144 0 0 0 0 0 0 0 0.008197 5.28E-05 1.09E-09 0 0.004574 0 0 0 0 0 0 0 0 0.001395 0 0 0 0.004342 1.70E-07 6.03E-08 0 0.002174 0.004255 0

Wiley-Blackwell and Society for Applied Microbiology Page 348 of 848

RubrobacterHyperthermus xylanophilusThermoanaerobacter strainbutylicus DSMFlavobacteriaceae strain 9941-08 DSM pseudethanolicusCandidatus 5456-08 bacterium RenibacteriumHamiltonella strain 3519-10-08Mycobacterium ATCC defensa salmoninarum 33223-08 strainPseudomonas sp. 5AT strain MCS-08 (AcyrthosiphonPseudomonas ATCC stutzeri 33209-01 strain syringaepisum)-30 A1501-30 pv. syringae strain B728a-01 0.105917 0 0 0.036999 0 0.00302 0.002116 0.297113 0.005827 4.25E-08 0 0 0.232503 0 0 0.001153 0.111666 0.001619 0.002932 0 0 0.24158 0.025888 0 0 0.068725 0.005232 0.003854 0 0 0.328929 0.061426 0 0 0.371294 0.010323 0.003829 0 0 0.241112 0 0.000756 5.20E-05 0.119897 0.005772 0.000207 0 0 0.195852 0.34573 0 0 0.159817 0.011812 0.015153 0 0 0.145091 0 6.01E-05 0.001843 0.08442 0.008194 2.60E-10 0 0 0.330395 0 4.47E-06 0.002373 0.233156 0.010387 0.004982 For0 Peer0 0.141095 Review0 1.56E-05 0.000965 Only0.10493 0.004578 0.005533 0 0 0.295475 0 6.81E-14 0.000152 0.062611 0.006535 0.002453 0 0 0.185917 0 0.001028 0 0.397952 0.0064 0.001502 0 0 0.263596 0 0.000235 0 0.292642 0.008543 0.002442 0 0 0.313539 0.017912 0.000144 0.001075 0.139661 0.028039 0.00155 0 0 0.070462 0.006559 0 0.001199 0.01133 0.00219 0.02613 1.02E-08 0 0.110608 0.046975 0.001726 0.004108 0.177345 0.006357 0 0.000456 0 0.042269 0 3.60E-05 0 0.142814 0.002919 0.017268 0.001098 0.009187 0.097328 0.002638 1.60E-05 0 0.090146 0.009459 0.003318 0 0 0.136173 0 0 0 0.136539 0.001617 0.005411 0 0 0.305111 0 0 0.001714 0.145258 0.023779

Wiley-Blackwell and Society for Applied Microbiology Page 349 of 848

ShewanellaAnaplasma baltica strain Candidatusmarginale OS223-08 strain CampylobacterBlochmannia St. Maries-01Thermoproteus floridanus-08 curvus Geobacterstrain neutrophilus 525.92-08 sp.Sorangium FRC-32-30 strain Nitrosococcuscellulosum V24Sta-30 Salmonellastrain oceani 'So cestrain enterica 56'-01 ATCC subsp. 19707-08 arizonae serovar 62:z4;z23:---30 0.008109 0 0 0.003041 0 0 0.007377 0.18541 0 0 0 0 0 0 0.001431 9.53E-10 0.093737 0 0.008556 2.07E-10 0 8.53E-09 0 0.017022 8.49E-06 0.04525 0 0.020705 0 0 0 0 5.82E-06 3.18E-11 0.048484 0 0.005855 0.004178 0 0 0 0.002046 2.13E-06 0.021702 0 0.030179 6.61E-07 0 0 0 0 4.23E-05 0.096901 0 0 0 0.01805 0.000104 0 0.012464 0.000615 0.091369 0 0 0 0 0 0 0 2.50E-05 0 0 0.013523 For0 Peer0 0 Review0 0.001595 4.85E-05 Only0.016129 0 0.021651 0 0 0.000196 0 0.005296 0.000254 0.068607 0 0.01928 0 0 0 0 0.000414 1.13E-05 0.06731 0 0 0 0 0 0 0 0.000198 0.111915 0 0 0 0 0 0 0 1.67E-07 0.099669 0 0 0 0 0 0 2.50E-05 0.000333 0.010906 0 0.006443 0 0 0 0.002535 0.046336 0.00068 0.096489 0 0.003469 0 0.002242 4.72E-05 0 1.28E-11 0.000176 0.025305 0 0.007233 0.001977 0 0.015761 0 0.034018 0.001323 0.089577 0 0.01305 0.000286 0 0 0 0.008959 1.36E-06 0.030367 0 0.022504 0 0 0.006674 0 0.000874 0.000103 0.096579 0

Wiley-Blackwell and Society for Applied Microbiology Page 350 of 848

ShewanellaCatenulispora baltica strainMethylocella OS155-01acidiphilaStaphylococcus strainsp. BL2-08 DSMStreptococcus 44928-08 aureusSalmonella subsp. pneumoniae aureus Chlamydophilaparatyphi Mu50-01 strain C HydrogenobaculumCGSP14-01 strain abortus RKS4594-01Escherichia str. S26/3-01 sp. coli Y04AAS1-01 strain SMS-3-5-01 0.001133 0.004498 0.048775 0 0 0.001553 0 0.001289 0 0.001426 8.38E-08 0.009406 0 0 0 0 3.38E-21 0 0.001811 0.003187 0.016342 0 0 0 1.30E-24 1.07E-05 1.18E-05 0.001771 0.000115 0.004555 0 0 0 0 0.00058 0 0.001179 0.000123 0.001084 0 0 0 0 0.006021 0.000121 0.004854 8.02E-05 0.011467 0.000982 0 0 0 1.96E-06 0.000683 0.002663 0.000229 0.027271 0 0 0 0.000975 0.001952 0 0.004259 3.79E-09 0.003931 0 0 0.000893 0 0.002429 0.001118 0.001374 2.01E-06For0.017945 Peer0 Review0 0 Only0 0 0 0 0.000198 0.012673 0.000198 0 0 0 0.00015 0 0.002341 0.000326 0.009867 3.07E-06 0.000419 0 0 0.003404 6.38E-06 0.001121 4.67E-05 0.000224 0 0 0 0 2.44E-05 0 0.004155 0.000112 0.014936 0 0 0 0 0.002506 0 0.00058 3.71E-10 0.007821 0.001184 0 0.00082 0 0.003404 0 0.00379 0.002262 0.026985 0 0 0 0 0 0 0 0.000519 0.005708 0 0 0 2.12E-16 0.001444 0 0.003049 0.000538 0.024982 0.00056 0 0 0.002529 0.000121 0 0.000695 0.002167 0.004461 0 0 0 0 0.001304 0 0.005169 0.000144 0.010727 0 0 0 0 0.000444 0

Wiley-Blackwell and Society for Applied Microbiology Page 351 of 848

Leptospira interrogansLeptothrix cholodniiThermoplasma serovar Copenhageni strainYersinia acidophilumSP-6-30 pestis strainHelicobacter bv. strainFiocruz MicrotusShewanella DSM mustelaeL1-130-01 str. 1728-01 91001-30 Arcobacter strainbaltica 12198-30 strain Clostridiumbutzleri OS185-08 strainPseudobacterium botulinum RM4018-08 B1 strain sepedonicum-30 Okra-30 0.018813 0.298921 0.032501 0 0.102005 0.007252 0.01875 0 2.00E-14 0.000601 0.050763 0 0 0 0 0.018751 0 0 0.001619 0.00839 0 8.29E-05 0 0.006173 1.56E-07 0.01434 0 0.000147 0.004519 0 0 0 0 0 0 0 5.61E-05 0.011831 0 0 0 0 0.019726 0.011157 0 0.002995 0.074568 0 0 0 0 0.003794 1.85E-07 0 0.003004 0.01652 2.16E-15 0 0 0 0.008686 0 0.02717 0.004182 0 2.60E-14 0 0 0 0 0 0 0.000522 0.026111For Peer0 0 Review0 0 0.000228 Only0.00164 0.002479 0.002395 0.004284 6.13E-09 0 0 0 0.004507 0.033598 0 0.002628 0.006289 8.65E-05 0.000283 0 0.021618 0.007254 0 0.032251 0.000303 0.012766 0.000219 0 1.51E-10 0.042808 9.53E-12 0 0 0.002222 0.020324 0 0 0 0.043341 0.011727 0.012218 0 0.00126 0.003601 2.82E-06 0 0.003652 0 1.72E-23 0.006701 0 0.003987 0.027508 7.23E-12 0 0.026107 0 0.056975 6.27E-05 4.02E-18 0.000999 0.001116 0 0 9.92E-07 0.005012 0.002043 0 0.005857 0.004265 0.013339 0.00025 0 0 0.009053 0.008671 0 0 0.000653 0.001119 0 0 0 0 0.018628 0.035806 0.021511 0.004298 5.29E-05 0 0 0.000492 0 0.012652 0 0.000331

Wiley-Blackwell and Society for Applied Microbiology Page 352 of 848

CaldicellulosiruptorLeptospira saccharolyticus borgpeterseniiBrachyspiraAcinetobacter hyodysenteriae strain serovar DSM PyrobaculumHardjo-bovis 8903-30 baumannii strainSulfurihydrogenibium WA1-30 arsenaticumstrain strain L550-30 ATCCChlorobium 17978-08strain DSM sp.Helicobacter phaeobacteroides YO3AOP1-08 13514-08Shewanella pylori strain woodyi B38-01DSM 266-08strain ATCC 51908-01 0 0.000282 0.437702 0 0 0.018433 0.011219 0 0.002768 0 0 3.504089 0 0 0 0.001751 0 0.00292 0 0 0.269246 0 0 0 0.004976 0 0.005233 0 0 0.394944 0.032562 0 0 0.00538 0 0.019792 0.009701 0.003877 0.227155 0.016393 0 0 0.001171 0 0.007164 0 0 1.979543 0 0 0.010781 0.001265 0.000222 0.016843 0 0 0.335001 0 0 0.003731 0.011278 0 0.012392 0 0 2.639675 0 0 0 0.002062 7.46E-15 0.010612 0 For0 0.263421 Peer0 Review0 0.003368 0.000188 Only 0 0.006939 0 2.99E-14 1.014194 0.024096 0 0 0.000497 0 0.008372 0 0 3.257652 0.034879 0 0 0.000947 5.52E-05 0.00987 0 0.004317 0.592981 0.049544 0 0 0.001355 0 0.014022 0.016686 1.22E-06 0.844578 0.036197 0 0 0.0003 0.000715 0.025844 0 0 0.609766 0.004397 0 0 4.82E-05 0 0.004222 0.002526 0 0.096325 0.010378 8.11E-12 0.018303 0.004218 0 0.007444 0 0 0.534407 0.010299 0 0.005192 0.000185 0 0.002765 0.013552 0.018747 0.043411 0 0 0.004628 0.004913 0 0.012961 0 0 0.289063 0 0 0 0.001886 7.44E-08 0.002653 0 0 0.478366 0.045698 0 0 0.000606 0 0.0278

Wiley-Blackwell and Society for Applied Microbiology Page 353 of 848

RhodopseudomonasAlicyclobacillus palustrisActinobacillus acidocaldarius strainNeisseria HaA2-01 pleuropneumoniae subsp. meningitidisBacillus acidocaldarius subtilis Yersiniastrainserovar subsp. 053442-01 strain 7pseudotuberculosis strain Lawsoniasubtilis DSM AP76-30 446-30str. intracellularis ThermotogalesBGSC strain1A700-08Alicyclobacillus PB1/+-08strain bacterium PHE/MN1-00-08 TBF acidocaldarius 19.5.1-08 subsp. acidocaldarius strain DSM 446-08 0.008155 0 0.000181 0 0 0 0 0.000165 0.040266 0.000531 0 0 0.00072 0 0 0 0 1.11E-11 0.001841 0.00737 0.001746 0 1.92E-06 0.006202 0 0 8.13E-05 0.001433 0 0 0.003148 0 0 0 0 0 0.003151 0.007783 0 0 0 0 0.00102 0 0.000143 0.00145 0 0 0.004343 0 0.021521 0.004076 0 1.14E-14 0.005772 0 0 0 0 0 0 0 0.00897 0.003231 0 0.42064 0 0 0 0 0 0 0.003326 0.006266For Peer0 0.003473 Review0 0 0.000157 Only 0 0.003752 0.004225 0 0 0.001685 0 0 0.00048 0 0.002054 0.004529 0 0 0.005104 0 0.013525 0 0.000338 0.000155 0.002864 7.01E-12 0.08352 0.003021 0 0 0 0 0 0.001713 0.003577 0.003316 0 0 0.0272 1.10E-09 0 1.40E-05 0.002831 0 0 0.001038 0 0 0 0 0.000575 0.006477 0.000485 0 0 0 0 0.003899 0.000175 0.001541 0.004551 0.004237 0.016801 0 0 0 0.003041 0 0.000439 0.003221 0.008487 0 0 0 0 0.021674 0.004761 0.008438 0.001096 0 0 0 0 0 0 0 0 0.002648 0 0.01097 0.008849 0 0.016233 0.001612 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 354 of 848

Candidatus MarinomonasBlochmanniaDesulfohalobium floridanus-30sp. MWYL1-01Pantoea retbaense ananatisHelicobacter strain strainPseudomonas DSM LMGpylori 5692-01 20103-01 strainLeptospirillum J99-30aeruginosaPseudomonas strainferrooxidans LESB58-01Bifidobacterium sp. ATCC AM1-30 53993-30 dentium strain Bd1-30 0 0.041033 0.006896 0.002192 0 0.007513 0.051052 0.000775 0 0 0.03481 0.000586 0.000211 0 0.001913 0 0 0 0 0.072145 0.001726 0.000935 0.045457 0.004551 0 0.002685 0 1.03E-12 0.119044 0.001113 0.003563 0 0.013832 1.14E-05 0.007277 0 0 0.026935 0.001107 0.001578 0 0.006589 0 0.000956 0 0 0.174108 0.002031 0.003311 0.22813 0.014183 0 0.00826 0 0 0.069622 0.001489 0.003097 0 0.011077 0.005921 0.004989 0 0 0.116541 0.002814 0.002812 0 0 0 0 0 0 0.035128For0.001195 Peer0.0017 0.023337Review0.006375 Only0 0.001777 0 0 0.098967 0.000985 0.001777 0 0.008548 0 1.36E-16 0 0 0.06833 0.00155 0.002677 0 0.00729 0.029136 0 0 0 0.054653 1.77E-05 0.002178 0 0.009915 0 1.89E-19 0 0 0.419964 0.003881 0.004736 0 0 0 3.86E-16 0 0 0.0218 3.12E-05 0.001484 0 0.004362 0 0.001468 0 0 0.067988 0.000958 0.003074 0 0 0.020262 0.010775 0.021501 0 0.015979 0.001357 0.001249 0 0.003375 0.000282 0.003528 0 0 0.112756 0.001989 0.003735 0 0.010433 0.026472 0.002982 0 0 0.014515 0.00064 0.000344 0 0.002658 0 1.72E-11 0 0 0.398252 0.000395 0.002885 0 0.026589 0 2.79E-05 0

Wiley-Blackwell and Society for Applied Microbiology Page 355 of 848

Pseudomonasepsilon sp. strain proteobacteriumStreptococcus ADP-01 Synechococcus AmH-01dysgalactiaeSynechocystis sp. subsp. CC9311-30Histophilus equisimilis sp. PCC 7942-08 Arthrobactersomnistrain GGS_124-08str. 129PT-30Shewanella chlorophenolicusPectobacterium trabarsenatis-30 strain A6-30 wasabiae strain WPP163-01 0 0.00065 0 0.027645 0 0 0.000536 0.037808 0.000166 0 0.000211 0 0.058499 0.041014 0 0 0 0.00196 0 0.001278 0 2.579029 0.043535 0.010256 0.000132 0 0.001011 0 0 0 0 0.037757 0.061709 0.009451 0.043612 0 0.050267 0.000792 0 0.323143 0.015754 0 0.001438 0.009644 0.00225 0 0.000442 0 0.037891 0 1.490116 0 0 0.002717 0 3.34E-05 0 0 0.036922 0.1344 5.59E-08 0 0.002191 0 4.59E-05 0 0.001423 0 0 0 0.002761 0 0 0.000977For Peer0 3.756874 Review0 0 0.004458 Only0.024768 0.001712 0 2.93E-05 0 0.06072 0.060474 0.293382 1.10E-21 0.018181 0.002576 0 0.001905 0 0.099191 0.029656 0.370082 0 0.020353 0.002311 0 0.001738 0 1.497658 0.085512 0.053141 0 0.091919 0.001399 0 2.84E-05 0.008436 0.010602 0 0.08271 0 0.015629 0.003769 0 0.001192 0 12.59602 0 0.143868 0 0.014024 0.000899 0 0.005145 0 0 0 0.07333 0.017125 0.010656 0.001561 0 0.001297 0 5.700307 0 0.111686 0 0.018852 0.000452 0 0.004363 0.000207 7.81E-05 0 0 0.000914 0.008507 0.001535 0 0.000628 0 0.00576 0.010763 0.106641 0.02954 0.05404 0.00052 0 1.62E-07 0 0.002336 0.042403 0.061696 8.52E-09 0.023736 0.005233

Wiley-Blackwell and Society for Applied Microbiology Page 356 of 848

DesulfovibrioBacillus vulgaris thuringiensis subsp.Vibrio sp.vulgaris Ex25-01strainMycobacterium DP4-08 Al Hakam-30Kangiella bovis koreensis subsp.Thauera bovis strainsp.Haloarcula MZ1T-30str. DSM AF2122/97-01 16069-08 marismortuiShigella flexneriMethanococcus strain serotype ATCC 43049-01 2a jannaschii str. 2457T-08 DSM 2661-08 0.029842 0 0.003912 1.31E-05 0.136757 0.057372 9.31E-05 0 0.009514 3.98E-08 0.039896 0.001368 0.000126 0.362127 0 0 0 0 4.55E-06 0.012921 0.004382 0 0.174388 0.000296 0 0 0 0.001545 0 0.006915 0 0.288121 0.094412 0 0 0 0.002077 0 0.004046 0 0.101185 0.007143 0 0 0 0.000563 0 0.008452 0 0.385363 0.001187 8.75E-09 0 0 0.000367 0 0.005258 0 0.162987 0.001622 0 0 0 0.00033 0 0.01044 0 0.344952 0 0 0 0 0.00335 For0 0.004381 Peer0 0.142799Review0.012693 Only0 0 0 0.000822 0.003202 0.004923 0 0.316707 0.010482 0 0 0 0.001045 0 0.006026 0 0.427854 0.008047 1.88E-05 0 0 0 0.001087 0.004004 0 0.209588 0.018815 0 0.023788 0 0.003396 0 0.023889 6.95E-06 0.518805 0.023278 0 0 0.002915 0 0.010445 0.002467 0 0.02909 0.000293 0 0 0 0 0 0.004999 0.000476 0.24073 0.081372 1.29E-06 0 0 0 0 0.002474 0 0.101035 0.014754 0 0 0 0.004184 0.004923 0.007662 0 0.177673 0.023206 1.01E-07 0 0.005829 0.003311 0 0.000258 0 0.162278 0.000238 0 0 0 0.000567 0 0.015643 0 0.497449 0.032617 2.88E-06 0.022761 0

Wiley-Blackwell and Society for Applied Microbiology Page 357 of 848

Erwinia amylovoraMycobacterium strainSilicibacter CFBP1430-08 tuberculosis Burkholderiapomeroyi strain DSS-3-08Clostridium KZN pseudomallei 1435-30Archaeoglobus difficile strain strain MSHR346-08Desulfomicrobium 630-01fulgidusYersinia strain VC-16-30baculatum pseudotuberculosisBacillus straincereus DSM strain strain 4028-30 B4264-08 IP 31758-01 0.002865 0 0.462971 0.003084 0.001288 0 0.000143 0 0 0.011468 0 2.124489 0.00456 1.42E-14 0 0 0.000929 0 0 0 3.58188 0.002277 1.26E-05 0.018934 0.000751 0.000492 4.69E-05 0.020006 0 4.239674 0 0.00094 0 0.065971 0 0 0 0.000487 3.439407 0.00188 1.01E-05 0.009245 0.008215 0 0 0.013317 0 2.916149 0.002009 0.000223 0.057696 0 0.00314 0.000969 0.003287 0.004654 1.173139 0.001117 0.00107 0.008128 0.023533 0.001885 0 0.008022 0 2.246578 0.000689 2.09E-05 0 0 0.000798 0 0.004254 0.001972For1.23315 Peer0.00332 1.19E-13Review0 0.009974 Only 0 0 0.015227 0 1.597221 0.002758 0.000238 0 0.030907 0 0 0.019557 0 1.685948 0.001973 9.15E-05 0 0 0 0 0 0 3.852509 0.003006 0.000644 0 7.80E-09 0.000511 0 0.03904 0 3.04502 0.007323 0 0 0.025307 0 0.000992 0 0 0.464509 0.000461 0.000556 0.000931 0.002321 0 0 0 0.000984 1.521517 0.006748 1.30E-10 1.97E-27 0.034892 0.001964 0.005497 0.004907 0 1.141715 0.002859 0.00018 0 0.003464 0 0 0.006384 0.00049 0.840584 0 2.16E-05 0.016887 0.031665 0 0.001298 0 0 2.680378 0.003387 4.31E-09 0 6.86E-05 0 0 0.026525 0 3.342613 0.006728 4.30E-05 0 1.58E-06 0.003139 0

Wiley-Blackwell and Society for Applied Microbiology Page 358 of 848

SynechococcusDesulfitobacterium sp. PCC7002-08Sebaldella hafniense termitidisHaloferax DSM strainvolcaniiVerrucomicrobiales 10664-30 ATCC strain 33386-30Deinococcus DS2-30 str.Shewanella PB90-1-01radioduransHaemophilus woodyi str. R1-01 strainThermosipho influenzae ATCC 51908-08 strainafricanus PittGG-01 strain TCF52B-01 0.02562 0 0 0 0.035352 0.001824 0.020223 3.22E-12 0 0.055383 0 0 0 0.000456 3.23E-21 0.130655 0.00848 0.001884 0.080144 0 0 0 0.000381 2.76E-21 0.04749 0.008819 7.20E-05 0.02141 0 0.00013 0 0.002773 0 0.081089 0.002195 0 0.024853 0 0 0 0.00133 0.001131 0.039403 0 1.72E-06 0.033684 0 0.000198 0 0.000581 0.000311 0.084454 0.011555 6.34E-05 0.020017 9.11E-05 0 0 0.002923 0.001547 0.030909 0.009628 6.51E-06 0 0.029496 0 0 0.002693 1.82E-05 0.139371 0.008939 1.83E-18 0.018954 For0 Peer0 4.32E-05 0.001576Review3.15E-06 0.02511 Only0.002331 0 0.029243 0 0 0 0.000607 0.000303 0.097149 0.002545 3.05E-09 0.014278 0 0 0 0.003674 1.49E-07 0.132131 0.00499 6.63E-05 0.097872 0 0 0 0.001426 0.000121 0.101216 0 0.000878 0.019592 0 0 0 0.000668 0.003042 0.136893 0 1.13E-11 0.011658 0 0 3.70E-07 0.002688 0.00043 0.010387 0.002736 1.14E-05 0 0 0.008404 0.008392 0.002928 0.000608 0.063284 0.003259 0.000298 0.025982 0 0.002532 0 0.002409 0 0.022489 0.002641 0.000218 0.006357 0.007231 8.17E-06 0 0.004684 0.000656 0.049147 0.005101 1.38E-05 0 0 0 0 0.000713 0.000419 0.039924 0 2.07E-10 0.02307 0 0 0 0.000784 0.002183 0.109704 0 1.04E-08

Wiley-Blackwell and Society for Applied Microbiology Page 359 of 848

DesulfovibrioRickettsia vulgaris conorii vulgarisDictyoglomus strain (strainCarboxydothermus Malish turgidum Hildenborough)-01 7-30Anoxybacillus strain DSM hydrogenoformansBrucella 6724-01 flavithermus ovisBacillus strain strainstr. cereusATCC Z-2901-30 BuchneraWK1-30 25840-30 strain aphidicolaB4264-01Anaplasma str. marginale Bp (Baizongia strain pistaciae)-01 St. Maries-08 0.003255 0 0.006749 0.02427 0 0 3.39E-05 1.44E-15 0 3.78E-06 0 0 0 0 0 0 0 0.002881 4.07E-10 0 0 0 0 0 2.75E-14 0.001207 0.001685 0 0 0 0 0 0.074238 0 0.012125 0 5.50E-05 4.63E-12 0 1.35E-06 1.23E-09 0.021608 0 0.004315 0 8.23E-05 0 2.21E-10 0 0.018275 0 9.53E-11 0 0.022566 0.000112 0 7.70E-15 0.001064 0 0 0.000121 0 0.008712 0.001904 0 0 0 0 0.150596 1.74E-07 0 0 0.00042 For0 Peer0 0 0.002454Review0 7.69E-05 Only0.006409 0 0 0 0 0 0 0 2.19E-05 0 0.000244 0.000286 0 0.000924 0 0 0 0.000181 0.013371 0.008588 7.97E-08 0 0 0 0 0 0 0.012826 0 0.001076 0 0.001214 0 0.000294 0 2.18E-11 0.009151 0 0 0 0.000571 0 0 0.025104 0.000133 0.007358 0.009135 8.96E-05 0 0.000216 0.021356 0.038126 0 0.000167 0.000339 0 9.11E-05 0 0.000381 0.004633 4.14E-05 0.006416 0.000105 0 0 0.001291 0 0.003114 0.05231 0.006186 0.049458 3.06E-05 0.003962 0 3.42E-07 0 0 0 0 0 9.96E-05 0.000142 0.010028 0.000557 0 4.45E-05 0 0.002786 0 0 0.009789 0

Wiley-Blackwell and Society for Applied Microbiology Page 360 of 848

AlkaliphilusCitrobacter metalliredigens Orientiarodentium strain tsutsugamushi Caulobacter strainQYMF-01 ICC168-08Anaplasma vibrioidesstrain Ikeda-30 TreponemaphagocytophilumCB15-30 Frankia pallidum str. sp. subsp. HZ-01StreptococcusCcI3-08 pallidumPseudomonas sanguinis str. Nichols-08 strain fluorescens SK36-08 strain Pf-5-01 0.000965 0.006056 0 0.034317 0 0 0.003877 0 0.005535 0.000456 0 0 0 3.81E-07 0 0.005641 0 0.004727 1.43E-05 0.009135 1.21E-18 0 0.000393 0 0.002897 0.002943 0.005713 0.001676 0 0 0.005057 1.66E-23 0 0 0 0.008955 0.000364 0.003929 0.007931 0 0.000237 0 0.00172 0 0.003954 0.000102 0.004236 0 0 0.000184 0 0.00011 0.000142 0.011674 0.000617 0.004704 7.50E-33 0.021531 0.002626 0 0.002768 0 0.009442 0.000839 0.015628 0 0 0.002579 0 0.000105 0 0.008962 0.000333 0.003644For0.007079 Peer0.007068 0.000575Review0 0.002348 Only 0 0.002555 1.53E-06 0.014975 0 2.00E-17 2.93E-07 0 0.001723 0 0.007006 0.001316 0.020719 0.109423 0 0.003081 0 0 0 0.006878 0.000242 0.006221 0.040743 0.007128 0.001473 0 0 0 0.00709 1.24E-05 0.022108 0.049666 0 0.00165 0 0.002512 0.002712 0.029709 0.000168 0.000177 0.003457 0 0.001234 0 2.09E-05 0 0.002347 2.09E-05 0.012716 0 0.012621 0.00075 0 0.010677 0 0.006771 0.001618 0.003777 0.018158 0 0.000641 0 0.001842 0 0.002344 0.000169 0.004517 5.91E-05 0.013894 0.001028 0.005494 0.010187 0 0.008828 2.05E-05 0 0.091678 0.005588 0 0 0.001273 0 0.002063 0.000802 0.017974 6.76E-08 0.00226 0.000147 0 0.000117 0 0.02422

Wiley-Blackwell and Society for Applied Microbiology Page 361 of 848

Yersinia pseudotuberculosisRuthia magnificaPolaromonas strainstr. CmCorynebacterium PB1/+-01 (CalyptogenanaphthalenivoransEscherichia magnifica)-30 urealyticum strain Rickettsiacoli strain CJ2-08 strain prowazekiiMG1655-01Bacillus DSM 7109-08cereus strainAzoarcus strain Madrid sp. AH820-30Allochromatium EbN1-01E-08 vinosum strain DSM 180-30 0.002213 0.259942 0.038723 0.005066 0 0 0 0.009652 0.057837 0 0 0.034292 0 0 0.044652 0 0.000743 0.11428 0.000289 1.186559 0.018269 4.80E-17 0 4.72E-06 0 0.001609 0.026928 0.001335 0 0.013359 0 0 0 0 0.002995 0.105473 0.001706 0.190049 0.007251 0 0 0 0 0.003136 0.038957 0 1.292262 0.016143 0 0 0 0 0.006198 0.220238 0.001683 3.012866 0.01117 0 0 0.015869 0 0.006064 0.088905 0 0 0.045031 0 0 0 0 0.00742 2.29E-05 0.000893 1.418202For0.005587 Peer0 Review0 0 Only0 0.00506 0.06292 0.002849 2.000418 0.025103 0 0.000185 0.009725 0 0.004982 0.092641 0 0 0.020614 0 0 0.009243 0 0.005924 0.117671 0.000811 0.052738 0.001663 0 0 0 0 0.005302 0.062998 0.005818 1.226287 0.01892 0.000908 0 0 0 0.007756 0.014257 0.000812 0.284835 0.002789 0 0 0.013043 0 0.003401 0.018702 0.002856 4.176394 0.017681 0 0 0.006335 0 0.005115 0.411222 0.000269 0.157916 0.0033 0 0 0 0 0.003148 0.037648 0 2.356109 0.011876 0.000287 0 0 0.00099 0.009591 0.080992 0.000315 0.837518 0.004891 0 0 0 0 0.002013 0.040598 0.003855 1.881085 0.043409 0 0 0.005269 0 0.007244 0.067189

Wiley-Blackwell and Society for Applied Microbiology Page 362 of 848

Bartonella henselaePolynucleobacter strainCandidatus Houston-1-01 sp. QLW-P1DMWA-1-30 MicrococcusRiesia pediculicolaYersinia luteus USDA-08ATCCpestiscyanobacterium 9341-30 bv. MicrotusNitrosomonas UCYN-A-08str. 91001-01Prochlorococcus eutrophaDeinococcus strain marinus C91-30 radiodurans str. NATL1A-01 str. R1-08 0.003655 0.001053 0 0 0 0.000101 0.031211 0.001945 0.014767 0.002733 0 0 0 0 0 0 0.001185 0.010611 0.002184 0.010545 0 0 0 0.039068 0 0.001041 0.003689 0.001786 0 1.57E-08 0 0 0 0.047678 3.11E-07 0.006267 0.002974 0.059566 0 0 0.000458 0 0.03235 0.002887 0.004151 0.000494 0 0 0 0 0.003999 0.109996 0.000641 0.003903 0 0.001941 0 9.53E-10 0 0 0 0.002198 0.010577 0.001019 0 0 0 0 0 0 0.004281 0.007287 0.004007 0.021209For Peer0 0 Review0 0 Only0 0.004398 0.003755 0.001 0 0 1.13E-19 0.001236 0.027546 0 0.002272 0.005555 0.005597 0.013982 0 0 0 0 0.070817 0.006942 0.006977 0.002854 0 0 0 0 0 0.04364 0.001621 0.007662 0.00111 0 0 0 0 0 5.62E-23 0.002416 0.020847 0 0.02562 0 0 0 0.011235 0.001498 0.000774 0.000549 0.004892 0.032421 0 1.86E-05 0.000169 0.005045 0.142882 0.004422 4.40E-06 0 0.000756 0.006469 0 0 0 0 0.000595 0.003902 0 0.007576 0 0.007489 0 0 0.0131 0.002848 0.010944 0.000738 0 0 0.000138 0 0 0.000212 0.001113 0.001219 0.002255 0.034043 0 0.000455 0.000721 0 0.006769 0.001709 0.020617

Wiley-Blackwell and Society for Applied Microbiology Page 363 of 848

Desulfohalobiumbacterium retbaense Ellin6076-01Rhodococcus strainProchlorococcus DSM opacus 5692-30 strainHydrogenobacter B4-01 sp. MIT9303-01Bacillus thermophilus cereusMethylovorus ATCC strain14579-08Nitrosospira sp. TK-6-01 SIP3-4-30Shewanella multiformis baltica strain strain ATCC OS223-0125196-01 0.154012 0.02562 0.005964 0.006323 0 0 0 0.014164 0.004146 0 6.10E-05 0.000142 8.05E-05 4.91E-10 0 0 0.005682 2.56E-05 0.01399 7.05E-05 0.00077 0.000153 0 4.68E-05 0.019496 0.003195 0.00096 2.67E-05 3.98E-07 0.001954 0 0 0 0.068188 0.010998 0.002411 0.009484 0.000185 0.000321 0.000463 8.85E-05 0 0.002789 0.004297 0.001708 0 0.000207 0.001217 0.002963 0 0 0.162179 0.006404 0.003289 0.023441 0.001605 0.002429 3.65E-05 0.001583 0 0.117483 0.197968 0.001958 0 0.000835 0.001067 0.00056 0 0 0.011859 0.042015 0.0036 0.0008 1.53E-06For0.00106 Peer0.000804 0.000243Review0 0.048343 Only0.003582 0.000829 0 0.000582 0.001545 0.002324 0.000194 0 0.000497 0.010359 0.003047 0 0.000601 0.001074 0.000792 0.00017 0 0 0.013183 0.003062 0.043802 1.47E-08 0.000654 6.22E-11 0 0 0.046206 0.00354 0.001707 0 0.000638 0.00176 2.28E-07 0 0.000423 0.0031 0.007943 0.005904 0.019073 0.000859 0.000899 0.000534 3.53E-08 0.001363 0.026499 0.008575 0.000882 0.012959 0.000854 0.001053 0.000747 1.77E-07 0.000946 0 0.37982 0.002241 0.000401 0.000482 0.000247 0.000872 0 0 0.015398 0.003537 0.000868 0.00522 0.001693 0.001403 0.000157 0.000976 0.001053 0.042856 0.348906 0.002634 0 2.59E-05 0.000385 4.07E-05 7.38E-10 0 0.045864 0.001198 0.000386 4.41E-05 4.53E-06 0.001497 5.90E-05 0 0 0.041052 0.006483 0.004433

Wiley-Blackwell and Society for Applied Microbiology Page 364 of 848

ClostridiumLactobacillus acetobutylicumAcinetobacter salivarius strainHalorhabdus ATCCsubsp. sp. 824-30ADP1-08 salivariusBifidobacterium utahensis UCC118-08Rhodococcus strain lactis DSM AD011-08Anaeromyxobacter 12940-30 sp. RHA1-30Yersinia dehalogenanspseudotuberculosisKlebsiella pneumoniae strain strain 2CP-C-08 (SchroeterYPIII-30 1886) Trevisan 1887-01 0 1.47E-07 0.028026 0 0.016935 0.01097 0.016495 0 0 0 0 0.062574 0 0 0.007449 0 0 0 0 0 0.040737 0 0.002243 0.001728 0.00046 0.010472 0 0 0 0.039379 0 0 0.004269 0.001621 0 0 0.000341 0 0.026794 0 0 0.003674 6.54E-09 0 0 0 0 0.087535 0 0 0.028647 0.000306 0 0 2.33E-05 0 0.025518 0.003066 0 0 0.004171 0 0 0 0 0.09972 0 0 0 0.001719 0 0 0.009282 For0 0.029616 Peer0 Review0 8.76E-05 0.000576 Only0.002707 0.001491 0 8.97E-07 0.05758 0 0 9.34E-06 0.000966 0.008772 0 0 0 0.064277 0 0 0.000918 0.0012 0 0 0 0 0 0 0 0 0.002527 0.015633 0 0 0 0.076702 0 0 0.011345 0.001021 0 0 0.001087 0 0.016016 0 0 0.000191 0 0 0 0 1.23E-05 0.039266 0.009218 0 0.012575 0.012631 0 0 0 0.001727 0.028259 0 0 0 0.002358 0.011969 0 0.000125 0 0.030019 0.000122 0 0.00225 0.006556 0 0 0.003686 0 0.021758 0 0 1.00E-05 4.21E-16 0.010917 0 0 0 0.072253 0.005909 0 0 7.55E-05 0.015407 0

Wiley-Blackwell and Society for Applied Microbiology Page 365 of 848

Maricaulis marisRhodopseudomonas strainRenibacterium MCS10-08 palustrisKangiella salmoninarum strain koreensisSpirosoma BisA53-30 strain strain lingualeSphingomonas ATCC DSM strain33209-0816069-30Brucella DSM aromaticivorans 74-30abortusClostridium strain BalkwillWautersia S19-01cellulolyticum et al. eutropha 1997-01 strain JMP134-30 H10-01 0.104985 0.20198 1.62E-08 0.032217 0.060084 0 0 0.002246 0.000726 0.051069 0 0 0.119996 0.046918 0 0.003371 0 0.018507 0.052229 0.011775 0 0.088453 0.044663 0 0 2.19E-12 0.000606 0.053888 0.000463 0.002184 0.674747 0.031704 0 0.002227 0 0.011077 0.063732 0.004617 3.77E-06 0.182343 0.025485 0 0 3.74E-05 0.014789 0.025957 2.90E-05 0 0.205484 0.006577 0 0.001981 0.000405 0.001064 0.049376 0.027825 2.22E-06 0.248051 0.076215 0 0.007174 0.001197 0.017681 0.080839 0.003626 0 0 0.248305 0 0 0.000264 0.067179 0.049355 0.021101For Peer0 0.245098 0.015574Review0.007913 Only0 9.71E-08 0.00646 0.035089 0.040747 0.002845 0.165134 0.000972 0 0 1.86E-10 0.016115 0.059418 0.008192 0.000431 0.162151 0.064841 0.015357 0 0.000181 0.008014 0.010593 0.012048 0.008178 0.648705 0.024539 0 0 0.000562 8.44E-12 0.080601 0.01845 0.004312 0 0.019178 0 0 0 0.00223 0.018951 0.000214 0 0.031242 0.023955 0 0.001742 0.000549 0.00202 0.062213 0.027033 0.000443 0.446155 0.074771 0 0.006438 0.000627 0.022954 0.025238 0.000729 0.002091 0.293437 0.019544 0 0.004203 0.000147 0.003566 0.104431 0.007589 0.002884 0.107581 0.065131 0 0 0.001414 0.013416 0.017498 0.008053 0.000438 0.55776 0.021959 0 0.003115 0.00053 0.021268 0.066195 0.015632 0 0.317676 0.021548 0 0 8.35E-06 0.006919

Wiley-Blackwell and Society for Applied Microbiology Page 366 of 848

Vibrio choleraeBurkholderia strain MJ-1236-30Natrialba cenocepacia magadiiHydrogenobacter strain strain MC0-3-01Geobacter ATCC thermophilus 43099-30 sulfurreducensAzotobacter strainThiomicrospira vinelandii strain TK-6-08 PCA-08Fibrobacter strain denitrificans DJ-01Vibrio succinogenes ATCC cholerae 33889-08 subsp. strain succinogenesO395-01 S85-08 0.030549 0.002423 0.100843 0.016255 0.040448 0.009971 0.019196 0.024131 0 0 0.000461 0.276353 0 7.01E-05 0.004197 0.002171 0.009304 0.000794 0 0.000313 0 0 0.002521 0.008397 0 0.000136 7.35E-05 0 0.000594 0.059976 0 0.008664 0.029171 0.001962 0.001086 1.35E-06 0.112475 0.001045 0.020633 3.08E-08 0.002312 0.008937 0.012866 0.000437 0 0 0.000699 0.337567 0 0.004755 0.020836 0 0.001052 0.014461 0 0.000393 0.023829 0.005686 0.002004 0.015362 0.002104 0 0 0 0.000888 0.333032 0 0.000876 0.017107 0 5.01E-05 0 0.016003 0.00075For0.025899 Peer0 0.002751Review0.00963 Only0.002 0.002987 0.002757 0 0.00066 0.055419 0 0.00227 0.011205 0.009443 0.004246 0 0 0.001052 0.197883 0 0.00102 0.01072 0.00119 0.002565 0.004196 0.461194 0.000525 0.03684 0 4.78E-06 0.013809 0.000156 0 0 0 0.000462 0.067362 2.20E-05 7.98E-05 0.043881 0.013932 0.00056 0.001394 0.035783 0.000926 0.074932 0 0.001018 0.007887 0 6.48E-05 0 8.09E-08 0.001199 0.03844 0.009937 0.036087 0.00956 0.107267 0.011559 0.003392 0.177764 0.000227 0.008155 0 0.003033 0.006147 0.004718 0.003108 0.000386 0 0.001705 0.007091 0.00236 0.020743 0.01686 0.005309 0.017154 0.00518 0 0.000269 0 0 0.001565 0.002237 5.89E-11 0.001899 0 0 0.001706 0.018766 8.02E-09 0.004143 0.041078 0.000593 0.000725 0

Wiley-Blackwell and Society for Applied Microbiology Page 367 of 848

CorynebacteriumMethanococcoides glutamicumShewanella ATCCburtoniiBradyrhizobium violacea 13032-01 str. DSMstrainCoxiella 6242-30 DSS12-30 sp. burnetiiORS278-30Bacillus strain cereusDeinococcus CbuK_Q154-08 strain ATCCMethylobacterium deserti 10987-30 strainSalmonella VCD115-01 sp. CM4-08typhi CT18-08 0 0 0.126474 0.147257 0 0 0.001323 0.011188 0 0 0 0.03922 0 0 0.001775 0 0.001309 0 0 0 0.064713 0.014581 0 0.000532 2.00E-23 0.004984 0 1.49E-18 0 0.11368 0.009152 0 0 0.003219 0.003573 0 2.25E-05 0 0.049392 0.010953 0 0.016232 0.0013 0.002869 0.000567 1.37E-05 0 0 5.06E-10 0.070585 0 0.000399 0.002112 0 2.89E-05 0 0.040134 0.029166 0 0 0.001689 0.00803 0 0 0 0.01663 0.035183 0 0 0.00026 0.003504 0 0 For0 0.070593 Peer0.007698 Review0 0 0.000203 Only0.00321 7.54E-06 0.000113 0 0.059705 0 0 0.000149 0.001487 0.004766 0 0 0 0.292049 0.004487 0 0.040465 0.000569 0.003198 0.003348 0 0 0.238733 0.001339 0 0 0.000303 0.001713 0 0 0 0.032197 0.009205 0 0 0.000753 0.007266 0 7.46E-14 0.007045 0.027448 0.010782 0 0 0.000335 0.002619 0 1.36E-08 0.025359 0.075197 0.032437 0.073364 0.005252 0.000904 0.00412 0 9.33E-14 0.012305 0.074214 0.005199 0 0 9.01E-05 0.002861 0.000438 0 0.009379 0.043924 0.012976 0 0.001187 0.001276 0.009223 0 7.00E-06 0 0.162752 0.013006 0.02571 0 9.02E-05 0.00109 0 3.41E-05 0 0.045336 0.002074 0 0 0.001329 0.002045 0

Wiley-Blackwell and Society for Applied Microbiology Page 368 of 848

CryptobacteriumLegionella curtum pneumophilaArcobacter strain DSM Mycobacteriumbutzleri strain 15641-30 Corby-01strainMycobacterium RM4018-01 sp. KMS-08Ammonifex bovis subsp.Salmonella degensii bovis strain Candidatusenterica str. KC4-01AF2122/97-08 subsp. HalorhodospiraSulcia enterica muelleri serovar strainhalophila HeidelbergGWSS-30 strain SL1-01 str. SL476-01 0 0 0.010071 0 0 0.010036 0 0 0.03932 0 0.001528 0.000953 0 0 0.000315 4.77E-11 0 0.00425 0 0.001912 0.004141 0.000968 0 0 0 0 0.004822 0 0.002698 0.008975 0.000893 0 0 0 0 0.012242 0 0.005295 0.002217 0 0 0 0 0 0.005799 0 0.004452 0.004176 1.94E-05 0 0.001131 0 0 0.017128 0 0 6.66E-05 0 0 0.000104 0 0 0.022702 0 0.006348 0.002658 0 0 0 0.000818 0 0.022058 0 0.004167For0.000233 Peer0 Review0 3.98E-06 0.00049 Only0.000328 0.01309 0 0.002056 0.001438 0 0 0 0 0 0.007877 0 0.005924 0.00359 0 0 0 0 0 0.011499 0 0.005157 0.002626 0 0 0 0.001403 0 0.00788 0 0 0.004901 0 0 0 0.003137 2.94E-05 0.019412 5.15E-13 0.007111 0.003151 0 0 0.000986 0 0 0.007167 1.28E-07 0.005015 0.015351 0 0 0.00126 0 0.218576 0.011981 0 0.003156 0.002904 0.000724 0.000334 0 0 4.29E-05 0.008117 0.003252 0.006534 0.007077 0.001203 0 0.001632 0.001246 0.118502 0.018473 0 0.000895 0.00186 0.000842 0 2.55E-07 0.000505 0 0.002209 0 0.004658 0.003164 0 0 4.34E-17 0 0.097071 0.02382

Wiley-Blackwell and Society for Applied Microbiology Page 369 of 848

Escherichia Halomicrobiumcoli strain SE11-01Lactobacillus mukohataeiMycobacterium rhamnosus strainSalmonella DSM strain leprae 12286-08 Lc Dictyoglomus705-01 entericastrain TN-01 subsp.Clostridium turgidum entericaCaulobacter perfringens strain serovar DSM SchwarzengrundBacteroides sp.str.6724-08 K31-30 13-08 fragilis strain strain CVM19633-30 YCH46-01 0 0.002688 0 0.000341 0 0.005587 0 0.03898 0.004817 0 0 0 0 0 0 0.001109 0.001857 0.000254 0.000902 0 0 0 0 0 0 0.00321 0.000697 0 0 0 0 0.002175 0 0.007987 1.18E-05 0.000662 0 0 2.01E-06 0 0 0 0 0.011081 0.000889 0.000524 0 0 0 0 0 0.005777 0.027579 0.002121 0 0 0 2.34E-05 0 0 0 0.024808 0.001823 0 0 0 0.00065 0 0 0.010249 0.064117 0.001762 0 0.00094For Peer0 0 Review0 0.000126 Only0 0.001164 9.27E-05 0 0 0 0 0 0 0.001584 1.06E-17 0.001955 0 0 0 0 0 0 0.000596 0 0.0042 0 0.000482 0 0 0 0 0 0.000904 0.000511 0 0.000985 0 0 0 0.000296 0.001346 0.021881 0.003528 0 0.000677 0 0.000626 0 0.010823 0 0.007199 0.001268 0 0 0 0 0 0.010179 0 0.003896 0.00162 0 0 0 0.000303 0 0.000513 0 0.000211 0.000621 0 0 0.000546 0 0 0.003898 0.000137 0.012423 0.001921 0 0 0 0 3.97E-29 0 0.000378 0.037648 0.000234 2.53E-05 0 0 0 0 0 0 0.015536 0.0024

Wiley-Blackwell and Society for Applied Microbiology Page 370 of 848

Kangiella koreensisThauera strainsp.Mesoplasma MZ1T-08 DSM 16069-01Thioalkalivibrio florum strainAcidiphilum L1-01sp. HL-EbGR7-08Vibrio cryptum cholerae JF-5-01Burkholderia strain O395-30Burkholderia glumae strainProchlorococcus multivorans BGR1-30 strain sp. MIT9211-01 ATCC 17616-08 0.063744 0.057811 0 0.262374 0.030319 0 6.50E-17 0.002236 2.49E-05 0.012298 0.027963 0 0.184377 0.003694 0.436568 0 0.004073 0.000131 0.025137 0.009464 1.03E-06 0.08264 0.003099 0.019147 0.001752 0.001283 1.11E-05 0.039626 0.034704 0 0.135248 0.002676 0.162977 0.072967 0.00161 0 0.03569 0.015765 0 0.061216 0.00434 0.052455 0.000172 0.000426 0.001704 0.075366 0.044251 0 0.225289 0.004903 0.358125 0.000386 0.001839 0.000434 0.075932 0.025634 6.30E-07 0.167784 0.015105 0.013273 0.001134 0.00063 0.002121 0.065578 0.033613 4.10E-08 0.24413 0.006277 0.036207 0 0.001557 0.002429 0.043972 0.004929For Peer0 0.052996 0.010316Review0.051562 0.004073 Only0.001122 3.15E-06 0.053802 0.034574 6.03E-09 0.18256 0.003673 0.075368 0.015707 0.001082 0.000575 0.050809 0.038196 1.68E-06 0.310644 0.004516 0.098096 0.060201 0.002171 0.000491 0.043518 0.020317 0 0.106493 0.012701 0.082091 0.000991 0.002066 0.001198 0.111383 0.047483 2.53E-11 0.263978 0.007308 0.049864 0.01492 0.002288 0.0007 0.033629 0.004687 2.70E-12 0.043136 0.013351 0 3.51E-05 0.001084 0.001692 0.051926 0.02638 1.78E-09 0.292738 0.009043 0.045298 0.013681 0.000639 0.00297 0.0191 0.007615 0 0.065167 0.012899 0.072096 0.001446 0.000619 0.00029 0.063466 0.024381 9.94E-10 0.21282 0.00906 0.042206 0.003371 0.00169 0.000699 0.015778 0.008199 1.64E-11 0.097201 0.001845 0.035588 0.004573 0.000702 0 0.112699 0.041851 3.71E-08 0.191665 0.005757 0 0.002516 0.003291 0.002309

Wiley-Blackwell and Society for Applied Microbiology Page 371 of 848

Escherichia Chlorobiumcoli strain HS-30Lactobacillus phaeobacteroidesPseudomonas plantarum strainDehalococcoides strain DSMresinovorans JDM1-30266-30Desulfovibrio Delaportesp. VS-01Bacillus vulgaris et al. anthracis 1961-01 subsp.Lysinibacillus strainvulgarisEscherichia CDC sphaericus DP4-01 684-01 coli strain strain C3-41-01 CFT073-01 0 0.001082 0 0 0.024965 0.003459 0 0.000845 0 0 0 0 0 0 4.01E-06 0 1.13E-05 0 0 0.002524 0 0 0 4.32E-10 2.09E-05 0.000185 0 0 0 0 0 0 8.41E-12 0 9.49E-06 0 0 0.018156 0 0 0 5.84E-05 0.00075 1.54E-07 0.000989 0 0 0 0 0 0 0 0.000197 0 0 0.029347 0 0 0.000804 0.000156 0 6.53E-05 0 0 0 0 0.00219 0.001367 0 0 0.000341 0 0 0.006095For Peer0 0 Review0 0 1.52E-08 Only 0 0 0 0 0.014218 0 0 6.93E-05 0 7.11E-06 0 0 0 0 0 0 0.000389 0 0.00162 0 0.000654 0.001262 0 0 0 0 0 2.84E-05 0 0 0.0313 0 0 0 0.000126 0 6.06E-05 0 0 0 0 0 0 7.65E-05 0 2.42E-05 0.000662 0 0.005324 0 0 0.001094 0 0 0.000127 0 0.000692 0 0.000223 0 0 2.42E-06 0 4.06E-05 0.000752 0 0.006587 0 0 0.003216 0.001372 6.44E-05 0.0016 0.000797 0 0.001251 0 0 0 3.64E-07 0 3.92E-05 0 0 0.008855 0 0 0 0.000693 0.000176 0.000641 0

Wiley-Blackwell and Society for Applied Microbiology Page 372 of 848

ArthrobacterRuegeria sp. FB24-08 sp.Chlamydia PR1b-01 trachomatisSynechococcusBorrelia MoPn sp. strainCC9605-30 duttoniiEscherichia Nigg-08 strain Clostridium coliLy-01 O157:H7Haemophilus tetani str. EC4115-08 str. E88-08Lactobacillus ducreyi str. sakei 35000HP-01 subsp. sakei strain 23K-08 0.000246 0.049886 0.007275 0.029802 0 0 0.018761 0.003414 0 0.000279 0 0 0.131407 0 0 0 0.000157 0 1.81E-05 0 0 0.030113 0 0 6.51E-07 0.001035 0 0.002921 0 0 0 0 0 0 0 0 0.003276 0.07202 0 0.010897 0 0 0.000354 0 0 0.000767 0 0 0.164682 0 0.005921 1.39E-06 0.005303 0 0.000115 0 0 0 0 0 0 0.004958 0 7.57E-08 0.006015 0 0.009201 0 0.0108 0 0.004263 0 4.07E-06 For0 Peer0 0.061184 Review0 0 0.001237 Only0.001958 0 0.004891 0 0 0.026024 0.000124 0 0.003313 0 0 0.001993 0.012604 0 0.089385 1.95E-11 0 0.003428 0.002187 0 0.002723 0.036652 0 0.004629 4.48E-05 0 0 0 0 0.006876 0.000102 0 0.011964 0 0.003156 0 0.010984 0 0 0 0 0.345626 0 0 0 0 0 3.99E-05 0 0 0.00041 0 0 0.008268 0.001906 0 4.12E-08 0 5.27E-12 0.312729 0 0.000586 0 0 0 0.002104 0 0 0.002353 0 0 0.007771 0.004029 2.65E-30 0.000368 0 0 0 0 0 1.66E-06 0.001015 0 0.006014 0.027444 0 0.045727 0 0 0 0.002666 0

Wiley-Blackwell and Society for Applied Microbiology Page 373 of 848

cyanobacteriumYersinia UCYN-A-01 pestisPseudomonas strain Z176003-08Acidimicrobium aeruginosaWolinella str. ferrooxidans UCBPP-PA14-01 succinogenesMagnetococcus strainAcidovorax strain DSM sp. 10331-08DSM MC-1-01 Francisellasp. 1740-30 JS42-08 philomiragiaAcetobacter pasteurianussubsp. philomiragia IFO 3283-01-01 strain ATCC 25017-08 0.001111 0 0.009306 0.187452 0.065325 0.029096 0.025406 0.098955 0.005455 0.006658 0 0.001908 0 0 0.000899 0.012065 0 0.002862 0.00345 0.007463 0.004844 0 0.031753 0.003139 0.008546 0.034487 0.00259 0 0 0.013449 9.14E-13 0 0.002728 0.005353 0.022085 0.002795 0 0 0.006633 1.42E-06 0 0.001187 0.009863 0.01332 0.004212 0 0 0.014721 0 0 0.005151 0.01982 0.071053 0.003024 0.000104 0 0 0.065201 0.005353 0.004199 0.01559 0.07726 0.006583 0.004381 0 0.015191 0.028333 0 0.005017 0.013967 0 0.002924 1.54E-08 For0 Peer0 2.15E-17 Review0 0.003035 0.004731 Only0.030984 0.004461 0 0 0.008585 0.002797 0.026174 0.002745 0.01289 0.050886 0.001913 0 0 0.007757 0.000228 0 0.004712 0.012765 0.038689 0 0.00056 0 0.01062 0 0 0.004912 0.020678 0.007962 0.004107 7.27E-06 0 0.034422 0 0.01795 0.004182 0.026559 0.043338 0.003174 0.009922 0.006905 0.004745 0 0 0.002911 0.000132 0 0.009605 5.74E-08 0 0.007926 0.16182 0 0.014002 0.035214 0.055668 0.005609 0.000989 0 0.003706 0.001757 0 0.002392 0.002075 0.020536 0.006685 4.19E-05 0 0.010987 0.117381 0.01242 0.012559 0.005083 0.021387 0.004923 0.001169 0 0.002565 0 0 0.000688 0.010143 0.025536 0.001586 0.002148 0 0.02726 0 0.000673 0.004112 0.01913 0.04237 0.000621

Wiley-Blackwell and Society for Applied Microbiology Page 374 of 848

Salmonella methanogenicenterica subsp.Sulfolobus archaeon enterica islandicusShewanella 6A8-30serovar strainEnteritidisStaphylococcus sp. MR-7-30 M.16.4-01 strainStreptomyces epidermidisP125109-08Burkholderia scabies ATCC 87.22-01 Rickettsia12228-08 mallei strain africaeVariovorax NCTC ESF-5-08 10247-08 paradoxus strain S110-30 0 0.018149 0 0.035475 0.040652 0.001876 4.57E-07 0 0.083197 0 0 0 0 0 2.42E-05 0.003662 0 0.134862 0 0 0 0.025079 0 9.32E-06 0.001106 0 0.005995 0 0 0 0 0 0.000358 0.001472 0 0.039291 0 0 0 0.032323 0 0.000135 0.0013 0 0.007376 0 0 0 0.08124 0 6.76E-05 0.000851 0 1.00E-05 0 0.036367 0 0.051282 0 0.001209 0.000605 0 0.034508 0 0.12709 0 0.003297 0 0.000196 0.001235 0 0.146052 0.009955 For0 Peer0 0.037067 Review0 0.000135 2.09E-11 Only0.01029 0.028314 0 0 0 0.04832 0 0.000264 0.002161 0 0.054672 0 0 0 0.064397 0 7.64E-05 0.001722 0 0.055592 0 0 0 0 0 0.000155 0.002333 0 0.014887 0 0 0 0.012712 0.004462 9.51E-05 0 0 0.0027 0 0 0 0.024594 0 0.000543 0 0 0.01724 0 0.000637 0 0 0 0.0005 0.001993 0 0.006101 0 1.68E-05 0 0.025249 0 1.85E-06 0.000817 0 0.027498 0 0.006383 0 0.008895 0 0.000417 0.000845 0 0.016494 0.0047 0 0 0.061931 0 4.26E-09 0.000335 0 0.051629 0 0 5.00E-07 0.026194 0 5.54E-09 0.002263 0.001259 0.000613

Wiley-Blackwell and Society for Applied Microbiology Page 375 of 848

NitrosococcusClostridium halophilusCatenulispora kluyveri strain Nc4-08strainMycobacterium acidiphila DSM 555-30Corynebacterium strain avium DSM Listeriastr. 44928-30 104-30 glutamicum monocytogenesBorrelia strain duttoniiIdiomarina strain R-30 strain 08-5923-01 Corynebacteriumloihiensis Ly-08 strain L2TR-08 nigricans CN-1-01 0.259877 0 0.000364 2.28E-07 0 0 0 0.0588 0.001168 0.075159 0 0 0 0 0 0 0.213498 1.25E-21 0.041797 0 8.45E-06 0 0 0 0 0.07663 4.68E-05 0.037586 0 0.008561 0 0 0 0 0.201352 1.22E-11 0.030112 0 9.02E-10 0 0 0 0 0.110768 2.55E-08 0.06626 0 1.05E-05 0 0 0 0 0.35409 3.74E-05 0.088266 9.38E-06 2.43E-05 0.003303 3.07E-10 0 0 0.0927 0.000115 0.095829 0 0 0 0 0 0 0.211285 0 0.016709 For0 Peer0 0 0.007553Review0 6.73E-16 Only0.081506 0 0.038699 0 0.007283 0 1.21E-18 0 0 0.193416 0 0.061343 0 0.021001 0 0 0 0 0.246915 0 0.041358 0 3.36E-09 0 1.76E-07 0 0 0.273617 0.001042 0.101116 0 0.009532 0 0 3.79E-08 0 0.377161 0 0.025669 0 0 0.005799 0 0 0 0.046372 0.001086 0.120813 0 0.004286 2.25E-12 0 0 0 0.109663 7.91E-08 0.017559 0 0.006218 0 0 0 0 0.084491 0 0.107312 0.002246 0.008821 0.005087 0.000167 0.000345 0 0.112371 0 0.026756 0 0 0 0 0 0 0.127859 1.53E-05 0.105406 0 0 0 0 0 0 0.223252 0.000331

Wiley-Blackwell and Society for Applied Microbiology Page 376 of 848

NeorickettsiaPseudomonas sennetsuPleuropneumonia str. aeruginosa Miyayama-01Anaerococcus strain agalactiae-01 PA7-01Synechococcus prevotii Geobacillusstrain sp. DSM PCC Stenotrophomonas 20548-017425-08sp. Y412MC10-08Wolinella maltophilia succinogenesEscherichia strain coli strain R551-3-08strain DSM E24377A-01 1740-01 4.93E-06 0.009926 0 0.000585 0.008462 0.010461 0.027201 0.015938 0 0 0.001735 0 0 0.022409 0 0.031078 0 0 0.00015 0.004569 0 0 0.032241 0.000562 0.012217 4.68E-07 1.16E-05 1.47E-13 0.014369 0 0 0.011896 0 0.011381 0.000129 0 0.00643 0.007296 0 0.000207 0.008785 0.001428 0.004756 4.01E-10 0 0.000233 0.015982 0 0 0.013532 1.47E-14 0.010665 0.001064 0 0 0.012178 0 0.000237 0.01592 0.00145 0.012219 0.000935 4.39E-05 0 0.013286 0 0 0.024839 0.002244 0.006042 0.003521 0.000991 0 0.006501For0.000436 Peer0 0.002709Review0.002115 0.001076 Only0.001583 0 0 0.008862 0 0.000953 0.010886 0.000726 0.002905 0.000556 0 0 0.007756 0 0.002154 0.012823 6.02E-08 0.008856 0.002903 0 0 0.010603 0 0 0.078039 0 0.005674 3.28E-07 0.000807 0 0.034121 0 0 0.018012 0.004083 0.032303 0.00234 0 0 0.004974 0 0.000416 0.01258 0 0.001041 0.00058 0 0.003016 0.009942 0 0 0.016104 0.011561 0.024671 0.001645 0 0 0.003075 0 0 0.004898 0.002932 0.001728 0.002196 0 0.004602 0.011839 0 0 0.006536 0.004647 0.013355 0.000866 0 0.0025 0.002392 0 3.94E-05 0.013927 0.001492 0.001904 5.09E-05 0 0 0.026084 0 0 0.003237 0.000829 0.022893 0.00067 0

Wiley-Blackwell and Society for Applied Microbiology Page 377 of 848

ShewanellaMaricaulis frigidimarina marisHeliobacterium strain strain NCIMBStaphylococcus MCS10-01 modesticaldum 400-01Yersinia aureus pestis strainSalmonella subsp. strain Ice1-08 aureus Nepal516-08 Synechococcustyphimurium str. MW2-08Synechocystis LT2-30 sp. RF-2-08Desulfitobacterium sp. PCC 7942-01 sp. Y51-30 0.004251 0.041238 0.016625 0 0 0 0 0.00613 0.037042 0.000149 0.003648 0 0 0 0 0.011148 0 0 0.002325 0.007052 0.001295 0 0.005027 0 0.012966 0.004178 0 0.012348 0.010181 0 0 0.014459 0 0 0.000185 0 0.00402 0.010262 0.000665 0 0 0 0.010455 0 0 0.006071 0.008201 7.90E-10 0 0 0 0 0.007425 0 0.005587 0.011966 0.000847 0 0.010604 0 0 0 0 0.006683 0.008576 0 0 0 0.026904 0 0 0.025058 0.003572 0.015716For0.00168 Peer0 Review0 0 Only0 0 0 0.004064 0.006581 0.002724 0 0 0 0 0 0 0.004333 0.007816 0.003457 0 0.010148 0.016717 0.003552 0 0 0.006664 0.019226 0 0 0 0 0 0.001596 0 0.019687 0.013508 0.003147 0 0 0 0 0 0 0.002262 0.013951 0.000572 0 0 0 0 0 0.009777 0.002371 0.011728 0.007268 0.001504 0 0 0.00678 0 8.67E-09 0.002488 0.014482 0.001301 0 0 0.008116 0.008022 0.001908 0 0.004708 0.018804 0.014688 0 0 0 0.0039 0.003145 0.006465 0.0049 0.0057 6.25E-11 0 0 0 0 0 0 0.013258 0.010949 0.000221 0 0 0.004092 0 0.003151 8.25E-05

Wiley-Blackwell and Society for Applied Microbiology Page 378 of 848

ChlamydophilaStaphylococcus pneumoniaeStreptococcus aureus AR39-01Nitratiruptor subsp. pneumoniae aureusSphingopyxis sp. N315-08 strainSB155-2-30 SynechocystisATCC alaskensis 700669-08Shewanella strain sp. PCC RB2256-30 7942-30Haemophilus sp. MR-7-01Rhodospirillum influenzae strain centenum PittGG-08 strain SW-08 0 0 0 0.119309 0.321562 0 0.003025 0.01037 0.365243 0 0 0 0 0.1133 0 0.000423 0 0.031157 0 6.80E-11 0 0 0.106318 0 0.000856 0 0.056415 0 0 0 0 7.68E-05 5.79E-09 0.004395 0 0.022116 0 0 0 2.55E-09 0.048461 0 0.002651 0.034428 0.018941 0 0 0 0 0.037623 0.005326 0.004013 0 0.051051 0 0 0 0 0.034489 0.108097 0.002302 0 0.215096 0 0 0 0 0.003065 0 0.003882 0 0.103503 0 For0 Peer0 0.011835 0.013801Review0 0.001162 Only 0 0.027537 0 0 0 0 0.000485 0 0.002639 0 0.040248 1.15E-06 0 0 0 0.004978 0.302452 0.003293 0.023382 0.045559 0 0 0 0.000229 0.091665 0 0.001761 0.132639 0.034198 0 0 0 0 0.01406 0 0.008857 0 0.055365 0 0 0 0 0.006106 0 0.001302 0 0.014586 0 0 0 2.82E-09 0.002394 0 0.003206 0 0.217768 0 0 0 0 0.017711 0 0 0.009471 0.029838 0 0 0 0.009954 0.030151 0.049467 0.003175 0.027116 0.297066 0 0 0 0 0.044353 0 0.001228 0 0.016447 0 0 0.003021 0 0.032445 0 0.004073 0.038187 0.03571

Wiley-Blackwell and Society for Applied Microbiology Page 379 of 848

ClostridiumCorynebacterium botulinum ThermusBa4 strain glutamicum thermophilus 657-01Chloroflexus strainRhizobium strain sp. R-01 Y-400-fl-30 HB27-01 radiobacterPseudomonasPediococcus K84-01 aeruginosaMethanococcus pentosaceus str. UCBPP-PA14-30Methanococcus strain maripaludis ATCC 25745-30 maripaludis strain C6-08 strain C6-01 0.000234 0.000335 0.003171 0.008575 0.02277 0.039392 0 0 0.000228 1.52E-05 9.02E-22 0 0.038806 0.002278 0.03255 0 0 0 1.09E-08 0 4.94E-22 0 0.00495 0.019895 0 0 0 0 0 4.78E-26 0 0.012091 0.15819 0 0 0 8.53E-07 0 3.17E-06 0 0.004418 0.027276 0 0 0 1.91E-06 0.000263 4.66E-05 0 0.005852 0.087078 0 0 0 2.81E-05 0.000111 0.004758 0 0.009942 0.024389 0 0 0 0.000698 1.13E-05 0 0.170464 0.00781 0.032152 0 0 0 1.12E-05 For0 0.000227 Peer0.000553 0.009192Review0.030407 Only0 0 0 1.08E-05 0.00042 0 0 0.008243 0.047061 0 0 1.48E-05 0.000138 4.23E-05 0.00125 0.012178 0.005955 0.078306 0 0 0.00021 3.04E-13 7.75E-06 1.54E-06 0 0.007182 0.085672 0 0 0 0.00011 0.000689 0 0 0.008903 0.03889 0 0 0 3.55E-05 0 0 0.001161 0.004654 0.012974 0 0 0 0.00049 5.26E-08 0 0 0.011522 0 0 0 0.00062 1.20E-05 0 0.000662 0.003505 0.005082 0.056079 0.003813 9.31E-05 0 7.53E-05 7.67E-15 0.004119 0.002532 0.007385 0.015042 0.003574 0 0.00052 7.07E-06 0 0.000252 0.027018 0.002017 0.057697 0 0 0 2.43E-05 0 4.46E-18 0.000549 0.009938 0.05937 0 0.008348 0

Wiley-Blackwell and Society for Applied Microbiology Page 380 of 848

Legionella pneumophilaJannaschia Ralstoniasp. strain DFL-12-08 Corby-08 solanacearumCitrobacter Ralstoniakoseri strain strain MolK2-08 solanacearumHerminiimonas ATCC BAA-895-30Dictyoglomus strain arsenicoxydans GMI1000-30Mycobacterium thermophilum MullerCandidatus boviset H-6-12-01 al. 2006-01BCG Sulcia strain muelleri Tokyo strain 172-08 DMIN-30 0 0.203031 0.005023 0 0 0.020556 0.005855 0 0 0 1.079718 0.005024 0 0 0.006813 0.001502 0 3.356149 0 2.556727 0.003653 0.007696 0.000404 0.004511 0 0 3.26E-10 0 3.235032 0.003698 0.008781 0.001563 0.012019 0 0 1.090763 0.005012 1.938283 0.001766 0.00233 0.003038 0.008325 0 2.80E-05 7.85E-06 0 1.556336 0.01193 0.018757 0 0.011298 1.98E-10 0.000133 0 0 0.958692 0.006916 0 0.001188 0.016238 2.30E-15 0 0.754877 0 1.468555 0.010409 0 0.003999 0.012391 0 0 0 0 0.842964For0.001366 Peer0.003926 0.000706Review0.009292 Only0 0 2.90E-05 0.025077 1.142356 0.00452 0.001758 0 0.010008 0 0.000266 0 0.017822 1.112031 0.006741 0.035808 0.002673 0.01544 0.002009 0.000229 0 0 1.873676 0.000805 0.040931 0 0.009468 0 0 0 0.035392 1.968147 0.006602 0.000676 1.22E-05 0.017718 0 0.009953 0.239666 0.00669 0.341227 0.00097 0 0.001812 0.011502 0.000254 7.72E-05 0.004422 0 1.074605 0.003782 0.003274 0.004095 0.017382 3.75E-09 0 0.453825 0 0.714069 0.000901 0.008398 0.003601 0.005404 0.000341 0 0 0.027587 0.676971 0.005696 4.09E-05 0.001202 0.011119 0.004205 0 0.120059 0.004618 2.083945 0.000773 0.00203 0 0.007131 2.49E-05 0 0.051852 0.018676 2.313784 0.009768 0 0.000135 0.011619 3.99E-05 0 0.440204

Wiley-Blackwell and Society for Applied Microbiology Page 381 of 848

Nostoc sp. PCCListeria 7937-30 monocytogenesMoorella thermoaceticaMethylobacterium strain HCC23-30Xanthomonas strain extorquensATCCPsychrobacter 39073-08campestris strainMethylotenera pv.cryohalolentisPA1-08 campestrisMethanothrix mobilis strainBacteroides strain K5-018004-01 thermophila JLW8-30 fragilis PT-01 strain NCTC 9343-30 0.043506 0 0.013704 0.012213 0.002063 0.00346 0 0.016275 0 0.036636 0.01684 1.08E-21 0.001204 0.00038 0 0 0 0 0.009379 0.002828 0 0.003961 0.001082 0.003557 0.025386 2.08E-11 0 0.000901 0 0 0.005578 0.000284 0.002338 0.080606 0 0.016655 0.003887 0 0 0.002677 0 0.004448 0.024338 0 0.048843 0.03546 0 0.000235 0.003142 0.000512 0.010535 0 0 0 0.030667 0.035615 0.012562 0.008198 0.002084 0.007429 0 6.39E-05 0.019182 0.107593 0.070729 0 0.006007 0 0.007609 0.06075 3.51E-15 0 0.007254 For0 0.000843 Peer0.003289 0.000698Review0.003842 Only0 0 1.63E-07 0.056379 0.002109 0.000379 0.005168 0.000399 0.006274 0.096665 0 5.24E-05 0.080803 0.022369 6.22E-08 0.00259 0.001722 0.005479 0.030779 0 0 0.029079 0 0 0.001936 0.00044 0.007648 0.18077 0 0.007131 0.053128 0.004655 0.000594 0.007661 0.001879 0.013381 0.045508 0 0 0.023088 0.005352 0 0.002903 0.000927 0.004513 0.03295 0.001438 0 0.00867 0 0.017724 0.008322 0.001609 0.006275 0 0.002371 0.029537 0.008752 0.002153 0.003378 0.00447 0.000525 0.003215 0.064648 3.71E-07 0.015702 0.006803 0.00775 0.016704 0.00961 0.002147 0.008116 0.02021 0.002501 0.012815 0.043106 0.004678 9.18E-14 0.00122 0.000213 0.002398 0.076703 0 0 0.04963 0.002764 0 0.002381 0.000875 0.012514 0.011967 0 0.018201

Wiley-Blackwell and Society for Applied Microbiology Page 382 of 848

NitrosococcusGeobacter halophilus lovleyiMycobacterium strain strain Nc4-01Methanosarcina SZ-30 lepraePropionibacterium strain barkeri Br4923-08bacterium strain acnesFusaro-08 Ellin6076-08Nitrosococcus strain KPA171202-01Jannaschina oceani strainStreptococcus sp. CCS1-01 ATCC 19707-30 mutans str. UA159-08 0.075796 0.000514 0.001473 0.002262 0.033158 0.059488 0.071422 0.03569 0 0.006995 0 0 0 0.002335 0 3.07E-17 0.014611 0 0.013174 1.20E-06 0 0.001821 0 0.000251 0.065902 0.04657 0.003593 0.013586 5.45E-06 0 8.96E-11 0 0.000251 0.129787 0.413019 0 0.008808 0.001686 0 0 0 0.002705 0.028706 0.167762 0 0.022126 0.014457 0 0 0 0.001635 0 0.105532 0 0.042242 0.025508 0 5.64E-06 0 0.005378 0.047723 0.088525 0 0.021551 0 0 0 0 0.003112 0.03947 0.115367 0 0.011019 0.007046For Peer0 0 1.86E-06Review0.001235 0.032193 Only0.111686 0 0.018153 3.75E-06 7.05E-07 0 0.002211 0.000221 0.048867 0.113245 0 0.014774 0.004273 0 0 0.005588 0.001043 0.055472 0.085576 0 0.007644 0.025317 0 0 2.81E-09 8.99E-13 0.218682 0.198796 0 0.041038 0 0 0.000241 2.52E-07 1.87E-05 0.070929 0.363596 0 0.010518 0.01006 0 0.003575 0.002118 0.00289 0.019256 0.104959 0 0.031705 0.067709 0 0.003771 0.00023 0.023259 0.179205 0.073921 0.00362 0.007516 0.021598 0 0.000202 8.96E-05 0.000994 0.054499 0.074108 0 0.030999 0.034364 0.001672 0.001445 0 0.008732 0.042072 0.066353 0 0.008735 0 0 0 0 0 0 0.093214 0 0.052647 0 0 0.005844 0.001234 0.000159 0.092737 0.317996 0

Wiley-Blackwell and Society for Applied Microbiology Page 383 of 848

PseudomonasSinorhizobium putida str. KT2440-30 meliloti strain 1021-08 0.030484 0.028683 0.046532 0.023504 0.034106 0.028228 0.101441 0.02828 0.02698 0.02275 0.037511 0.013323 0.016492 0.025138 0.052236 0.032508 0.027266 0.023097For Peer Review Only 0.020397 0.015456 0.101783 0.012569 0.062278 0.011644 0.029725 0.038429 0.004736 0.006434 0.032646 0.038244 0.020905 0.009353 0.014021 0.029631 0.027987 0.021734 0.048481 0.037428

Wiley-Blackwell and Society for Applied Microbiology Page 384 of 848

Table S3. Contributions of individual OTUs to variance between the North and South zones. OTU Synechococcus sp. CC9311-08 Synechococcus sp. CC9902-08 Synechococcus sp. CC9311-30 Synechococcus sp. CC9902-30 Pelagibacter ubique HTCC1062-30 Ruthia magnifica str. Cm (Calyptogena magnifica)-01 Colwellia sp. 34H-30 Ruthia magnifica str. Cm (Calyptogena magnifica)-08 Pelagibacter ubiqueFor HTCC1062-08 Peer Review Only Candidatus Vesicomyosocius okutanii strain HA-01 Coraliomargarita akajimensis strain DSM 45221-08 Coraliomargarita akajimensis strain DSM 45221-30 Roseobacter sp. OCh114-08 Pseudoalteromonas atlantica strain T6c-30 Candidatus Vesicomyosocius okutanii strain HA-08 Acinetobacter baumannii strain SDF-30 Gramella forsetii strain KT0803-08 Marinomonas sp. MWYL1-08 Roseobacter sp. OCh114-30 Flavobacterium psychrophilum strain JIP02/86-08 Silicibacter pomeroyi DSS-3-08 Brachyspira hyodysenteriae strain WA1-30 Ruthia magnifica str. Cm (Calyptogena magnifica)-30 Pseudoalteromonas haloplanktis strain TAC125-30 Robiginitalea biformata strain HTCC2501-08 Seattle Aquarium strain SCM1-01 Gramella forsetii strain KT0803-30 Lysinibacillus sphaericus strain C3-41-30 Seattle Aquarium strain SCM1-08 Silicibacter sp. TM1040-08 Zunongwangia profunda strain SM-A87-08 Haemophilus influenzae strain PittGG-30 Silicibacter pomeroyi DSS-3-30 Jannaschia sp. DFL-12-08 Cellvibrio japonicus strain Ueda107-08 bacterium 2-40-08 Flavobacterium psychrophilum strain JIP02/86-30 Bartonella henselae strain Houston-1-30 alpha proteobacterium IMCC1322-30 Silicibacter sp. TM1040-30 Sulcia muelleri SMDSEM-30 Teredinibacter turnerae strain T7901-08 Seattle Aquarium strain SCM1-30 Zunongwangia profunda strain SM-A87-30 alpha proteobacterium IMCC1322-08

Wiley-Blackwell and Society for Applied Microbiology Page 385 of 848

Flavobacterium johnsoniae strain UW101-08 Candidatus Sulcia muelleri strain DMIN-30 Robiginitalea biformata strain HTCC2501-30 Jannaschina sp. CCS1-08 Tropheryma whipplei str. TW08/27-30 Jannaschia sp. DFL-12-30 Jannaschina sp. CCS1-30 Marinomonas sp. MWYL1-30 Marinobacter hydrocarbonoclasticus VT8-08 Capnocytophaga ochracea strain DSM 7271-08 alpha proteobacteriumFor IMCC1322-01 Peer Review Only Pseudoalteromonas atlantica strain T6c-08 Synechococcus sp. PCC7002-30 Chromohalobacter salexigens strain DSM 3043-08 bacterium 2-40-30 Alcanivorax borkumensis strain SK2-08 Flavobacterium johnsoniae strain UW101-30 Thermosynechococcus elongatus strain BP-1-30 Haemophilus influenzae Rd KW20-30 Colwellia sp. 34H-08 Pelagibacter ubique HTCC1062-01 Candidatus Vesicomyosocius okutanii strain HA-30 Shewanella frigidimarina strain NCIMB 400-30 Synechococcus sp. CC9605-08 Mycoplasma conjunctivae strain HRC/581-30 Gramella forsetii strain KT0803-01 Roseobacter sp. OCh114-01 Histophilus somni str. 2336-30 Flavobacterium psychrophilum strain JIP02/86-01 Hahella chejuensis strain KCTC 2396-08 Capnocytophaga ochracea strain DSM 7271-30 Marinobacter hydrocarbonoclasticus VT8-30 Synechococcus sp. WH8102-08 Edwardsiella ictaluri strain 93-146-30 Robiginitalea biformata strain HTCC2501-01 Teredinibacter turnerae strain T7901-30 Microcystis aeruginosa NIES-843-30 Idiomarina loihiensis strain L2TR-30 Acetobacter pasteurianus IFO 3283-01-30 Histophilus somni str. 129PT-30 Kangiella koreensis strain DSM 16069-08 Pseudoalteromonas haloplanktis strain TAC125-08 Kangiella koreensis strain DSM 16069-30 Streptococcus mitis strain B6-30 Pseudomonas stutzeri strain A1501-08 Listeria monocytogenes strain Clip80459-30 Rhodobacter capsulatus strain SB1003-08

Wiley-Blackwell and Society for Applied Microbiology Page 386 of 848

Alcanivorax borkumensis strain SK2-30 Rhodobacter capsulatus strain SB1003-30 Silicibacter pomeroyi DSS-3-01 Cellvibrio japonicus strain Ueda107-30 Clostridium difficile strain R20291-30 Silicibacter sp. TM1040-01 Rhodobacter sphaeroides strain ATCC 17025-08 gas vacuolate str. 37-30 epsilon proteobacterium AmH-30 Synechococcus sp. PCC6301-30 Zunongwangia profundaFor strain SM-A87-01Peer Review Only Synechococcus sp. WH7803-08 Synechococcus sp. WH8102-30 Jannaschia sp. DFL-12-01 Akkermansia sp. Muc-30 Burkholderia sp. CCGE1002-30 Thiomicrospira crunogena strain XCL-2-30 Synechococcus sp. CC9605-30 Chlorobium phaeobacteroides strain BS1-30 Thioalkalivibrio sp. HL-EbGR7-30 gas vacuolate str. 37-08 Vibrio cholerae strain MJ-1236-30 Idiomarina loihiensis strain L2TR-08 Hahella chejuensis strain KCTC 2396-30 Synechococcus sp. strain RF-1-30 Prochlorococcus sp. MED4-08 Rhodobacter sphaeroides strain ATCC 17025-30 Chromohalobacter salexigens strain DSM 3043-30 Rubrivivax gelatinosus PM1-30 Xanthomonas campestris pv. campestris strain B100-30 Synechococcus sp. WH7803-30 Thioalkalivibrio sp. HL-EbGR7-08 Rhodobacter sphaeroides strain ATCC 17029-08 Synechococcus sp. CC9902-01 Capnocytophaga ochracea strain DSM 7271-01 Flavobacteriaceae bacterium 3519-10-30 Thiomicrospira crunogena strain XCL-2-08 Flavobacterium johnsoniae strain UW101-01 Natrialba magadii strain ATCC 43099-30 Clostridium difficile strain CD196-30 Escherichia coli strain SE11-30 Rhodobacter sphaeroides strain 2.4.1-08 Synechocystis sp.PCC6803-30 Marinomonas sp. MWYL1-01 Shewanella sp. W3-18-1-30 Synechococcus sp. OS-type A strain JA-3-3Ab-30 Paracoccus denitrificans PD1222-08

Wiley-Blackwell and Society for Applied Microbiology Page 387 of 848

Anaplasma marginale strain Florida-30 Rhodobacter sphaeroides strain KD131-08 Flavobacteriaceae bacterium 3519-10-08 Vibrio vulnificus str. YJ016-30 Pedobacter heparinus strain DSM 2366-30 Coraliomargarita akajimensis strain DSM 45221-01 Pseudomonas stutzeri strain A1501-30 Tolumonas auensis strain DSM 9187-30 Jannaschina sp. CCS1-01 Vibrio cholerae strain O395-30 Acaryochloris marinaFor MBIC11017-30 Peer Review Only Rhodobacter sphaeroides strain 2.4.1-30 Rhodobacter sphaeroides strain ATCC 17029-30 Azotobacter vinelandii strain DJ-08 Sphingobium japonicum strain UT26S-30 Vibrio parahaemolyticus str. RIMD 2210633-30 Xylella fastidiosa 9a5c-30 Synechococcus sp. strain JA-2-3B'a(2-13)-30 Cyanothece sp. BH68K-30 Azotobacter vinelandii strain DJ-30 Vibrio fischeri strain MJ11-30 Thioalkalivibrio sp. K90mix-08 Methanosarcina barkeri strain Fusaro-30 Rhodobacter sphaeroides strain KD131-30 Microscilla sp. PRE1-01 Francisella philomiragia subsp. philomiragia strain ATCC 25017-30 Proteus mirabilis strain HI4320-30 Methylococcus capsulatus str. Bath-08 Anaplasma phagocytophilum str. HZ-30 Pirellula staleyi strain DSM 6068-30 Lactobacillus fermentum strain IFO 3956-30 Shewanella amazonensis strain SB2B-08 Staphylothermus marinus strain F1-30 Synechococcus sp. PCC 7425-30 Paracoccus denitrificans PD1222-30 Rhodopirellula baltica strain SH 1-30 Trichodesmium sp. IMS101-30 Shewanella putrefaciens strain CN-32-30 bacterium 2-40-01 Cytophaga hutchinsonii strain ATCC 33406-30 Hyphomonas neptunium strain ATCC 15444-30 Synechococcus sp. RCC307-30 Novosphingobium aromaticivorans strain DSM 12444-30 Shewanella sp. PV-4-30 Shewanella frigidimarina strain NCIMB 400-08 Pseudomonas putida strain W619-08 Cellvibrio japonicus strain Ueda107-01

Wiley-Blackwell and Society for Applied Microbiology Page 388 of 848

Shewanella violacea strain DSS12-30 Pirellula staleyi strain DSM 6068-08 Thioalkalivibrio sp. K90mix-30 Teredinibacter turnerae strain T7901-01 Shewanella sp. WP3-30 Prochlorococcus marinus str. MIT 9301-30 Propionibacterium acnes strain SK137-30 Methanosarcina mazei strain Go1-30 Streptococcus suis str. P1/7-30 Psychrobacter sp. PRwf-1-08 Shewanella sediminisFor strain HAW-EB3-08 Peer Review Only Erythrobacter litoralis strain HTCC2594-30 Pseudomonas fluorescens strain Pf0-1-08 Pseudomonas aeruginosa str. UCBPP-PA14-08 Prochlorococcus marinus str. MIT 9515-30 Blattabacterium sp. Alboraia-30 Vibrio fischeri strain ES114-30 Shewanella sediminis strain HAW-EB3-30 Pseudomonas fluorescens str. SBW25-08 Pseudomonas aeruginosa str. PAO1-08 Xylella fastidiosa strain M23-30 Photorhabdus luminescens subsp. laumondii str. TTO1-30 Allochromatium vinosum strain DSM 180-08 Pseudomonas entomophila strain L48-08 Pseudomonas putida GB-1-30 Candidatus Sulcia muelleri strain DMIN-08 Anaplasma marginale strain St. Maries-30 Pseudomonas fluorescens strain Pf-5-08 Pseudomonas putida str. KT2440-08 Shewanella amazonensis strain SB2B-30 Prochlorococcus sp. MIT9211-30 Propionibacterium acnes strain KPA171202-30 Pseudomonas syringae pv. syringae strain B728a-08 Shewanella woodyi strain ATCC 51908-08 Methylococcus capsulatus str. Bath-30 Shewanella violacea strain DSS12-08 Xanthomonas campestris pv. campestris strain 8004-30 Prochlorococcus sp. MED4-30 Shewanella woodyi strain ATCC 51908-30 Burkholderia pseudomallei strain 668-30 Prosthecochloris aestuarii strain DSM 271-30 Pseudomonas aeruginosa strain LESB58-08 Akkermansia sp. Muc-08 Nitrosococcus oceani strain ATCC 19707-30 Allochromatium vinosum strain DSM 180-30 iron-oxidizing lithotroph ES-1-08 Shigella boydii strain CDC 3083-94-30

Wiley-Blackwell and Society for Applied Microbiology Page 389 of 848

Pseudomonas aeruginosa strain PA7-08 Pseudomonas putida GB-1-08 Prochlorococcus sp. MIT9303-08 iron-oxidizing lithotroph ES-1-30 Candidatus Amoebophilus asiaticus strain 5a2-30 gamma proteobacterium MLHE-1-08 Thermosynechococcus elongatus strain BP-1-08 Halothiobacillus neapolitanus strain c2-30 cyanobacterium UCYN-A-30 Shewanella pealeana strain ATCC 700345-08 Actinobacillus pleuropneumoniaeFor Peer serovar 3 str. JL03-30Review Only Vibrio sp. Ex25-30 Marinobacter hydrocarbonoclasticus VT8-01 Psychrobacter cryohalolentis strain K5-08 Aeromonas hydrophila subsp. hydrophila strain ATCC 7966-30 Methylotenera mobilis strain JLW8-30 Parvibaculum lavamentivorans strain DS-1-30 Pseudomonas putida strain F1-08 Pedobacter heparinus strain DSM 2366-08 Rhodopirellula baltica strain SH 1-08 Rubrivivax gelatinosus PM1-08 Synechococcus sp. RF-2-30 Parvibaculum lavamentivorans strain DS-1-08 Shewanella denitrificans strain OS217-30 Mesorhizobium loti strain MAFF303099-30 Nitrosococcus oceani strain ATCC 19707-08 Actinobacillus pleuropneumoniae serovar 7 strain AP76-30 Psychrobacter sp. 273-4-30 Tolumonas auensis strain DSM 9187-08 Desulfovibrio desulfuricans subsp. desulfuricans strain G20-30 Halothiobacillus neapolitanus strain c2-08 Zymomonas mobilis subsp. mobilis strain NCIMB 11163-30 Vibrio sp. Ex25-08 Vibrio salmonicida LFI1238-30 Leuconostoc mesenteroides subsp. mesenteroides strain ATCC 8293-30 Acinetobacter sp. ADP1-30 Shewanella sp. PV-4-08 Psychrobacter cryohalolentis strain K5-30 Synechococcus sp. RCC307-08 Vibrio harveyi strain ATCC BAA-1116-30 Haemophilus ducreyi str. 35000HP-30 Pseudomonas entomophila strain L48-30 Xanthomonas campestris pv. campestris str. ATCC 33913-30 Pseudomonas syringae pv. phaseolicola strain 1448A-08 Hyphomonas neptunium strain ATCC 15444-08 Rickettsia bellii strain OSU 85-389-30 deep-sea eubacterium SS9-30

Wiley-Blackwell and Society for Applied Microbiology Page 390 of 848

Synechococcus sp. PCC 7424-30 Natronomonas pharaonis strain DSM 2160-30 gamma proteobacterium MLHE-1-30 Shewanella halifaxensis strain HAW-EB4-30 Prochlorococcus sp. AS9601-30 Francisella tularensis subsp. novicida U112-08 Vibrio parahaemolyticus str. RIMD 2210633-08 Shewanella halifaxensis strain HAW-EB4-08 Burkholderia mallei str. ATCC 23344-30 Wautersia metallidurans CH34-30 Sphingopyxis alaskensisFor strain RB2256-30 Peer Review Only Variovorax paradoxus strain S110-30 Mycoplasma pneumoniae strain M129-30 Methylotenera mobilis strain JLW8-08 Pseudomonas syringae pv. tomato str. DC3000-08 Mannheimia succiniciproducens str. MBEL55E-08 Neisseria meningitidis serogroup B strain MC58-30 Mesorhizobium loti strain MAFF303099-08 Chromohalobacter salexigens strain DSM 3043-01 Dickeya dadantii strain Ech703-30 Methylovorus sp. SIP3-4-30 Candidatus Hamiltonella defensa strain 5AT (Acyrthosiphon pisum)-30 Francisella tularensis subsp. mediasiatica strain FSC147-30 Burkholderia pseudomallei strain MSHR346-30 Prochlorococcus sp. MIT9303-30 Thiomicrospira crunogena strain XCL-2-01 Burkholderia cenocepacia HI2424-30 Coxiella burnetii strain Dugway 5J108-111-08 Stackebrandtia nassauensis strain DSM 44728-30 Nitrosococcus halophilus strain Nc4-08 Cytophaga hutchinsonii strain ATCC 33406-08 Neisseria gonorrhoeae strain FA 1090-30 Vibrio cholerae strain MJ-1236-08 Haemophilus influenzae strain PittEE-30 Alcanivorax borkumensis strain SK2-01 Streptococcus suis strain 05ZYH33-30 Prochlorococcus marinus subsp. marinus str. SS120-30 Mycobacterium abscessus strain ATCC 19977-30 Pseudomonas aeruginosa str. PAO1-30 Nitrosomonas europaea str. ATCC 19718-30 Aeromonas hydrophila subsp. hydrophila strain ATCC 7966-08 Shewanella denitrificans strain OS217-08 Pseudomonas aeruginosa strain LESB58-30 Nostoc sp. PCC73102-30 Burkholderia mallei strain 10229-30 Coxiella burnetii strain CbuK_Q154-30 Pasteurella multocida subsp. multocida strain Pm70-08

Wiley-Blackwell and Society for Applied Microbiology Page 391 of 848

Chloroherpeton thalassium strain ATCC 35110-30 Synechocystis sp. PCC 7942-30 Blattabacterium sp. Alboraia-08 Spirosoma linguale strain DSM 74-30 Burkholderia pseudomallei strain 1106a-30 Acinetobacter sp. ADP1-08 deep-sea eubacterium SS9-08 Burkholderia mallei strain NCTC 10247-30 Rhodospirillum centenum strain SW-08 Vibrio salmonicida LFI1238-08 Rickettsia felis strainFor URRWXCal2-30 Peer Review Only Yersinia pseudotuberculosis strain IP 32953-30 Aeromonas salmonicida subsp. salmonicida strain A449-30 Thioalkalivibrio sp. HL-EbGR7-01 Acinetobacter baumannii strain SDF-08 Nostoc sp. PCC 7937-30 Shewanella sp. WP3-08 Xylella fastidiosa str. Temecula1-30 Pseudomonas aeruginosa str. UCBPP-PA14-30 Rhizobium radiobacter str. C58 (U. Washington)-08 Halorhodospira halophila strain SL1-30 Pasteurella multocida subsp. multocida strain Pm70-30 Ehrlichia ruminantium strain Welgevonden-30 Sulcia muelleri SMDSEM-08 Methylobacillus flagellatus strain KT-30 Desulfotalea psychrophila LSv54-30 Pseudomonas fluorescens strain Pf-5-30 Pseudomonas fluorescens str. SBW25-30 Thiobacillus denitrificans strain ATCC 25259-08 Magnetospirillum sp. AMB-1-08 Vibrio cholerae strain O395-08 Pseudomonas aeruginosa strain PA7-30 Dyadobacter fermentans strain DSM 18053-30 Heliobacterium modesticaldum strain Ice1-30 Halorhodospira halophila strain SL1-08 endosymbiont of Acanthamoeba sp. UWE25-30 Blattabacterium sp. (Periplaneta americana) strain BPLAN-08 Prochlorococcus marinus str. MIT 9515-08 Vibrio fischeri strain ES114-08 Geobacter sp. M21-30 Psychrobacter sp. 273-4-08 Dichelobacter nodosus str. VCS1703A-30 Kangiella koreensis strain DSM 16069-01 Nitrosospira multiformis strain ATCC 25196-08 Ochrobactrum anthropi strain ATCC 49188-08 Rhodobacter capsulatus strain SB1003-01 Prochlorococcus sp. MIT9313-30

Wiley-Blackwell and Society for Applied Microbiology Page 392 of 848

[Mesorhizobium] sp. BNC1-30 Prochlorococcus sp. MIT9313-08 Vibrio harveyi strain ATCC BAA-1116-08 Hahella chejuensis strain KCTC 2396-01 Maricaulis maris strain MCS10-30 Porphyromonas gingivalis strain W83-30 Burkholderia pseudomallei strain K96243-30 Geobacter uraniumreducens Rf4-30 Synechococcus sp. CC9311-01 Herpetosiphon aurantiacus DSM 785-30 Magnetospirillum sp.For AMB-1-30 Peer Review Only Dechloromonas sp. RCB-30 Pseudomonas fluorescens strain Pf0-1-30 Methylotenera mobilis strain JLW8-01 Pseudomonas syringae pv. tomato str. DC3000-30 Flavobacteriaceae bacterium 3519-10-01 Methylovorus sp. SIP3-4-08 Colwellia sp. 34H-01 Mycobacterium sp. JLS-30 Burkholderia vietnamiensis strain G4-30 Rhizobium radiobacter str. C58 (U. Washington)-30 Pseudomonas putida strain W619-30 Shewanella pealeana strain ATCC 700345-30 Synechococcus sp. PCC7002-08 Helicobacter pylori strain J99-30 Haemophilus influenzae strain PittGG-08 Pseudomonas syringae pv. phaseolicola strain 1448A-30 Rhodospirillum rubrum strain ATCC 11170-08 Nitrosococcus halophilus strain Nc4-30 boonei strain T469-30 Pseudomonas stutzeri strain A1501-01 Synechocystis sp. PCC 7942-08 Yersinia pseudotuberculosis strain PB1/+-30 Thiobacillus denitrificans strain ATCC 25259-30 Mannheimia succiniciproducens str. MBEL55E-30 Haemophilus parasuis strain SH0165-30 Orientia tsutsugamushi strain Ikeda-30 Methylobacillus flagellatus strain KT-08 Edwardsiella tarda strain EIB202-30 Histophilus somni str. 129PT-08 Vibrio fischeri strain MJ11-08 Rubrobacter xylanophilus strain DSM 9941-30 Xylella fastidiosa strain M12-30 Phenylobacterium zucineum strain HLK1-30 Acidimicrobium ferrooxidans strain DSM 10331-30 Pelobacter carbinolicus strain DSM 2380-30 Methanococcus vannielii strain SB-30

Wiley-Blackwell and Society for Applied Microbiology Page 393 of 848

Pseudomonas syringae pv. syringae strain B728a-30 Nitrobacter winogradskyi strain Nb-255-30 Nostoc sp. strain PCC 7120-30 Actinobacillus succinogenes strain 130Z-30 Aeromonas salmonicida subsp. salmonicida strain A449-08 Herminiimonas arsenicoxydans Muller et al. 2006-30 Pseudomonas putida str. KT2440-30 Coxiella burnetii str. RSA 493-30 Rothia mucilaginosa strain DY-18-30 Haemophilus parasuis strain SH0165-08 Acinetobacter baumanniiFor strain AB0057-08Peer Review Only Rhodobacter sphaeroides strain ATCC 17025-01 Nitrosospira multiformis strain ATCC 25196-30 Chlorobium limicola strain DSM 245-30 Anaeromyxobacter sp. Fw109-5-30 Sulcia muelleri SMDSEM-01 Vibrio vulnificus str. YJ016-08 Shewanella sp. MR-1-30 Nitrosomonas eutropha strain C91-30 Shewanella sp. W3-18-1-08 Legionella longbeachae strain NSW150-30 Hirschia baltica strain ATCC 49814-30 Brucella ovis strain ATCC 25840-30 Francisella philomiragia subsp. philomiragia strain ATCC 25017-08 Rhodospirillum rubrum strain ATCC 11170-30 Shewanella sp. MR-7-30 Parvibaculum lavamentivorans strain DS-1-01 Prochlorococcus sp. MIT9312-30 Neisseria meningitidis strain 053442-30 Gluconobacter oxydans strain 621H-08 Xanthomonas sp. Py2-30 Nitrosospira multiformis strain ATCC 25196-01 Rhodospirillum centenum strain SW-30 Desulfotalea psychrophila LSv54-08 Dichelobacter nodosus str. VCS1703A-08 Burkholderia sp. 383-30 Pseudomonas putida strain F1-30 Shewanella sp. MR-4-30 Pelodictyon luteolum DSM 273-30 Rhodobacter sphaeroides strain 2.4.1-01 Sorangium cellulosum strain 'So ce 56'-30 Xanthomonas axonopodis pv. citri str. 306-30 Synechococcus sp. PCC6301-08 Maricaulis maris strain MCS10-08 Shewanella trabarsenatis-30 Bacteroides fragilis strain YCH46-30 Haemophilus influenzae strain PittEE-08

Wiley-Blackwell and Society for Applied Microbiology Page 394 of 848

Neisseria meningitidis strain FAM18-30 Parabacteroides distasonis strain ATCC 8503-30 Aggregatibacter aphrophilus strain NJ8700-08 Azoarcus sp. EbN1-30 Mycobacterium vanbaalenii strain PYR-1-30 Vibrio cholerae serotype O1 biotype ElTor strain N16961-30 Burkholderia pseudomallei strain 1710b-30 Chitinophaga pinensis strain DSM 2588-30 Aggregatibacter actinomycetemcomitans strain D11S-1-30 Hirschia baltica strain ATCC 49814-08 Thermobaculum terrenumFor strain Peer ATCC BAA-798-30 Review Only Exiguobacterium strain 255-15-30 Oligotropha carboxidovorans strain OM5-30 Acetobacter pasteurianus IFO 3283-01-08 Chloroflexus sp. Y-400-fl-30 Psychrobacter sp. PRwf-1-30 Rhodobacter sphaeroides strain ATCC 17029-01 Brucella ovis strain ATCC 25840-08 Shewanella baltica strain OS195-30 Shewanella baltica strain OS185-30 Thauera sp. MZ1T-08 Herminiimonas arsenicoxydans Muller et al. 2006-08 Corynebacterium nigricans CN-1-30 Yersinia pestis strain Pestoides F-30 Ochrobactrum anthropi strain ATCC 49188-30 Magnetococcus sp. MC-1-30 Verrucomicrobiales str. PB90-1-30 Rhizobium sp. NGR234-30 Burkholderia cenocepacia AU 1054-30 [Mesorhizobium] sp. BNC1-08 Campylobacter lari strain RM2100-30 Laribacter hongkongensis strain HLHK9-30 Methylovorus sp. SIP3-4-01 Agrobacterium vitis strain S4-08 Vibrio cholerae serotype O1 biotype ElTor strain N16961-08 Polynucleobacter sp. QLW-P1DMWA-1-30 Granulobacter bethesdensis CGDNIH1-30 Histophilus somni str. 2336-08 Xenorhabdus bovienii strain SS-2004-30 Azoarcus sp. EbN1-08 gas vacuolate str. 37-01 Thiomicrospira denitrificans ATCC 33889-30 Brucella sp. CCM 4915-30 Erwinia tasmaniensis strain Et1/99-30 Acinetobacter baumannii strain ACICU-08 Rhizobium radiobacter K84-08 Burkholderia mallei strain SAVP1-30

Wiley-Blackwell and Society for Applied Microbiology Page 395 of 848

Ruegeria sp. PR1b-01 Laribacter hongkongensis strain HLHK9-08 Proteus mirabilis strain HI4320-08 Haemophilus influenzae strain 86-028NP-30 Synechococcus sp. OS-type A strain JA-3-3Ab-08 Granulobacter bethesdensis CGDNIH1-08 Yersinia pestis strain Angola-30 Alteromonas macleodii 'Deep ecotype'-01 Prochlorococcus marinus subsp. marinus str. SS120-08 Acinetobacter baumannii strain ATCC 17978-08 Bdellovibrio bacteriovorusFor strain Peer HD100-30 Review Only Streptococcus suis strain SC84-30 Diaphorobacter sp. TPSY-30 Nitrobacter winogradskyi strain Nb-255-08 Gluconobacter oxydans strain 621H-30 Minibacterium massiliensis-30 Actinobacillus succinogenes strain 130Z-08 Acidothermus cellulolyticus strain 11B-30 Pseudoalteromonas haloplanktis strain TAC125-01 Mycoplasma genitalium strain G37-30 Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578-30 Gloeobacter violaceus strain PCC 7421-30 Delftia acidovorans strain SPH-1-30 Chromobacterium violaceum str. ATCC 12472-08 Xenorhabdus bovienii strain SS-2004-08 Syntrophomonas wolfei subsp. wolfei strain Goettingen-30 Shewanella putrefaciens strain CN-32-08 Methylobacillus flagellatus strain KT-01 Agrobacterium vitis strain S4-30 Photorhabdus asymbiotica Fischer-Le Saux et al. 1999 emend. Akhurst et al. 2004-30 Buchnera aphidicola str. Sg (Schizaphis graminum)-08 Idiomarina loihiensis strain L2TR-01 Enterobacter sakazakii ATCC BAA-894-30 Beijerinckia indica subsp. indica strain ATCC 9039-30 Synechococcus sp. PCC 7425-08 Porphyromonas gingivalis strain W83-08 Eubacterium rectale strain ATCC 33656-30 Azoarcus sp. BH72-08 Neisseria gonorrhoeae strain NCCP11945-30 Caulobacter vibrioides CB15-08 Verminephrobacter eiseniae strain EF01-2-08 Rhizobium radiobacter K84-30 Citrobacter rodentium strain ICC168-30 Leptothrix cholodnii strain SP-6-30 Novosphingobium aromaticivorans strain DSM 12444-08 Paracoccus denitrificans PD1222-01 Coxiella burnetii strain Dugway 5J108-111-30

Wiley-Blackwell and Society for Applied Microbiology Page 396 of 848

Rhizobium sp. ORS571-30 Brachyspira hyodysenteriae strain WA1-08 Pseudomonas sp. LB400-30 Caulobacter crescentus strain NA1000-08 Leptothrix cholodnii strain SP-6-08 Caulobacter sp. K31-30 Thauera sp. MZ1T-30 Shewanella baltica strain OS155-30 Polaromonas naphthalenivorans strain CJ2-08 Stenotrophomonas maltophilia strain K279a-30 Chromobacterium violaceumFor str. Peer ATCC 12472-30 Review Only Prochlorococcus sp. MIT9211-08 Thioalkalivibrio sp. K90mix-01 Prochlorococcus sp. MED4-01 Methylocella sp. BL2-30 Rhodothermus marinus strain DSM 4252-30 Bacteroides vulgatus strain ATCC 8482-30 Azoarcus sp. BH72-30 Porphyromonas gingivalis strain ATCC 33277-08 Roseiflexus castenholzii strain DSM 13941-30 Bordetella petrii strain DSM 12804-30 Aggregatibacter aphrophilus strain NJ8700-30 Bartonella tribocorum strain CIP 105476-30 Chitinophaga pinensis strain DSM 2588-08 Bradyrhizobium japonicum str. USDA 110-30 Erythrobacter litoralis strain HTCC2594-08 Edwardsiella tarda strain EIB202-08 Sphingomonas wittichii strain RW1-30 Methylobacterium radiotolerans strain JCM 2831-30 Blattabacterium sp. Alboraia-01 Caulobacter crescentus strain NA1000-30 Prochlorococcus marinus str. NATL1A-30 Candidatus Sulcia muelleri strain GWSS-08 Prosthecochloris vibrioformis DSM 265-30 Edwardsiella ictaluri strain 93-146-08 Aggregatibacter actinomycetemcomitans strain D11S-1-08 Roseiflexus sp. strain RS-1-30 Blattabacterium sp. (Periplaneta americana) strain BPLAN-01 Candidatus Accumulibactor phosphatis Type IIA str. UW-1-30 Azospirillum sp. B510-08 Rhodothermus marinus strain DSM 4252-08 Slackia heliotrinireducens strain DSM 20476-30 Leifsonia xyli subsp. xyli strain CTCB07-30 Burkholderia glumae strain BGR1-30 Serratia proteamaculans strain 568-08 Rhodobacter sphaeroides strain KD131-01 Dyadobacter fermentans strain DSM 18053-08

Wiley-Blackwell and Society for Applied Microbiology Page 397 of 848

Prochlorococcus sp. NATL2A-30 Yersinia enterocolitica subsp. enterocolitica strain 8081-30 Haliangium ochraceum strain DSM 14365-30 Legionella longbeachae strain NSW150-08 Porphyromonas gingivalis strain ATCC 33277-30 Dickeya dadantii strain Ech703-08 Xanthomonas albilineans var. paspali-30 Magnetococcus sp. MC-1-08 Legionella pneumophila str. Lens-08 Stenotrophomonas maltophilia strain R551-3-30 Ehrlichia chaffeensisFor str. Arkansas-30 Peer Review Only Shewanella sp. MR-4-08 Rickettsia bellii strain OSU 85-389-08 Desulfomicrobium baculatum strain DSM 4028-30 methanogenic archaeon 6A8-30 Desulfohalobium retbaense strain DSM 5692-30 Francisella tularensis subsp. novicida U112-30 Microcystis aeruginosa NIES-843-08 Shewanella trabarsenatis-08 Sphingopyxis alaskensis strain RB2256-08 Acinetobacter baumannii strain AYE-30 Rickettsia bellii strain RML369-C-08 Buchnera aphidicola strain Tuc7 (Acyrthosiphon pisum)-08 Chlorobaculum parvum strain NCIB 8327-30 Nitrobacter hamburgensis strain X14-08 Polaromonas naphthalenivorans strain CJ2-30 Cenarchaeum symbiosum A-01 Wolbachia sp. wRi-30 Pectobacterium carotovora subsp. atroseptica str. SCRI1043-30 Verrucomicrobiae bacterium V4-30 Listeria monocytogenes strain HCC23-30 Burkholderia sp. PsJN-30 Acinetobacter baumannii strain AB0057-30 Nitrosococcus halophilus strain Nc4-01 Shewanella sp. MR-7-08 Salmonella enterica subsp. enterica serovar Dublin strain CT_02021853-30 Verrucomicrobiales str. PB90-1-08 Erwinia amylovora strain CFBP1430-08 Ralstonia pickettii strain 12J-30 Candidatus Accumulibactor phosphatis Type IIA str. UW-1-08 Brevibacillus brevis strain NBRC 100599-30 Acidithiobacillus ferrooxidans str. ATCC 23270-30 Synechococcus sp. strain JA-2-3B'a(2-13)-08 Shewanella baltica strain OS155-08 bacterium EX-H1-30 iron-oxidizing lithotroph ES-1-01 Denitrovibrio acetiphilus strain DSM 12809-30

Wiley-Blackwell and Society for Applied Microbiology Page 398 of 848

Bacteroides fragilis strain NCTC 9343-30 Haemophilus ducreyi str. 35000HP-08 Rhodospirillum centenum strain SW-01 Wautersia eutropha JMP134-30 Prochlorococcus sp. AS9601-08 Methylococcus capsulatus str. Bath-01 Fibrobacter succinogenes subsp. succinogenes S85-30 Allochromatium vinosum strain DSM 180-01 Zymomonas mobilis subsp. mobilis strain ZM4-08 Prevotella ruminicola strain 23-30 Polynucleobacter sp.For QLW-P1DMWA-1-08 Peer Review Only Rickettsia akari strain Hartford-30 Actinobacillus pleuropneumoniae strain L20-30 Rhodoferax ferrireducens strain T118-30 Yersinia enterocolitica subsp. enterocolitica strain 8081-08 Erythrobacter litoralis strain HTCC2594-01 Shewanella baltica strain OS223-30 Dechloromonas sp. RCB-08 Chlorobium tepidum strain TLS-30 Ferroglobus placidus strain DSM 10642-30 Bartonella bacilliformis strain KC583-08 Chloroflexus aggregans strain DSM 9485-30 Neisseria meningitidis strain alpha14-30 Deferribacter desulfuricans strain SSM1-30 Sinorhizobium meliloti strain 1021-30 Prochlorococcus sp. NATL2A-08 Gemmatimonas aurantiaca strain T-27-30 Sinorhizobium medicae WSM419-30 Rhodoferax ferrireducens strain T118-08 Nitrosomonas europaea str. ATCC 19718-08 Pseudoalteromonas atlantica strain T6c-01 Clostridium difficile strain 630-30 Deinococcus radiodurans str. R1-30 Acidithiobacillus ferrooxidans str. ATCC 23270-08 Wautersia eutropha H16-08 Pelobacter carbinolicus strain DSM 2380-08 Shewanella amazonensis strain SB2B-01 Erwinia pyrifoliae strain Ep1/96-08 Helicobacter acinonychis strain Sheeba-30 Ralstonia pickettii strain 12D-08 Coxiella burnetii strain CbuG_Q212-08 Salmonella enterica subsp. enterica serovar Heidelberg str. SL476-30 Trichodesmium sp. IMS101-08 Nitrosomonas eutropha strain C91-08 Azotobacter vinelandii strain DJ-01 Brucella abortus strain S19-08 Shewanella baltica strain OS185-08

Wiley-Blackwell and Society for Applied Microbiology Page 399 of 848

Acinetobacter baumannii strain ATCC 17978-30 Polaromonas sp. JS666-08 Azospirillum sp. B510-30 Rhizobium sp. NGR234-08 Prochlorococcus sp. MIT9215-08 Polynucleobacter necessarius subsp. necessarius strain STIR1-30 Burkholderia ambifaria strain MC40-6-30 Halothiobacillus neapolitanus strain c2-01 Pedobacter heparinus strain DSM 2366-01 Francisella tularensis subsp. tularensis strain SCHU S4-30 Citrobacter koseri strainFor ATCC BAA-895-30Peer Review Only Comamonas testosteroni strain CNB-2-30 Candidatus Sulcia muelleri strain GWSS-01 Leptospira biflexa serovar Patoc strain Patoc1-30 Shigella dysenteriae strain Sd197-30 Polaromonas sp. JS666-30 Francisella tularensis subsp. tularensis strain SCHU S4-08 Photorhabdus luminescens subsp. laumondii str. TTO1-08 Legionella pneumophila str. Paris-08 Neisseria meningitidis strain alpha14-08 Propionibacterium acnes strain SK137-08 Prochlorococcus marinus str. NATL1A-08 Nitrosococcus oceani strain ATCC 19707-01 Bradyrhizobium sp. BTAi1-30 Bradyrhizobium japonicum str. USDA 110-08 Acinetobacter baumannii strain AB307-0294-30 Spirosoma linguale strain DSM 74-08 Rhodopseudomonas palustris strain BisB18-30 Buchnera aphidicola strain 5A (Acyrthosiphon pisum)-08 Bartonella quintana strain Toulouse-08 Sulfurovum sp. NBC37-1-30 Shewanella sp. MR-1-08 Carsonella-Pv-01 Dickeya zeae strain Ech1591-30 Serratia proteamaculans strain 568-30 Rhodopseudomonas palustris strain BisA53-30 Chlorobium tepidum strain TLS-08 Mycobacterium sp. MCS-30 Shewanella baltica strain OS195-08 Cytophaga hutchinsonii strain ATCC 33406-01 Sulfurihydrogenibium azorense strain Az-Fu1-30 Brucella canis strain ATCC 23365-08 Thermomonospora curvata strain DSM 43183-30 Rhizobium etli strain CFN 42-08 Shewanella baltica strain OS223-08 Synechocystis sp.PCC6803-08 Prochlorococcus sp. MIT9215-30

Wiley-Blackwell and Society for Applied Microbiology Page 400 of 848

Xanthomonas sp. Py2-08 Pectobacterium carotovorum subsp. carotovorum strain PC1-08 Geobacter lovleyi strain SZ-30 Rhodopseudomonas palustris strain BisB5-30 Sinorhizobium meliloti strain 1021-08 Burkholderia multivorans strain ATCC 17616-30 Sinorhizobium medicae WSM419-08 Candidatus Amoebophilus asiaticus strain 5a2-08 Desulfomicrobium baculatum strain DSM 4028-08 Stenotrophomonas maltophilia strain R551-3-08 Yersinia pseudotuberculosisFor strain Peer YPIII-08 Review Only Prochlorococcus marinus str. MIT 9301-08 Rhizobium sp. ORS571-08 Sphingobium japonicum strain UT26S-08 Xanthomonas oryzae pv. oryzae strain PXO99A-30 Streptococcus zooepidemicus-30 epsilon proteobacterium AmH-08 Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2-08 Alkaliphilus metalliredigens strain QYMF-30 Desulfobacterium autotrophicum strain HRM2-30 Nitrobacter hamburgensis strain X14-30 Clostridium thermocellum strain ATCC 27405-30 Cloacamonas acidaminovorans-30 Legionella pneumophila subsp. pneumophila strain Philadelphia 1-08 Actinobacillus pleuropneumoniae serovar 7 strain AP76-08 Bordetella pertussis Tohama I-30 Burkholderia cepacia AMMD-30 Clostridium botulinum B1 strain Okra-30 Burkholderia cenocepacia strain MC0-3-30 Wautersia eutropha JMP134-08 Pseudomonas aeruginosa str. PAO1-01 Geobacter metallireducens strain GS-15-30 Ralstonia solanacearum strain IPO1609-30 Rhodopseudomonas palustris strain HaA2-30 Magnetospirillum sp. AMB-1-01 Polynucleobacter necessarius subsp. necessarius strain STIR1-08 Syntrophus aciditrophicus strain SB-30 Methylobacterium sp. BJ001-30 Bordetella avium strain 197N-08 Rhodospirillum rubrum strain ATCC 11170-01 Dickeya dadantii strain Ech586-30 Klebsiella pneumoniae strain 342-30 Brucella sp. CCM 4915-08 gamma proteobacterium MLHE-1-01 Rhizobium etli strain CFN 42-30 Variovorax paradoxus strain S110-08 Bartonella henselae strain Houston-1-08

Wiley-Blackwell and Society for Applied Microbiology Page 401 of 848

Streptococcus equi subsp. equi strain 4047-30 Wautersia eutropha H16-30 Thermococcus onnurineus strain NA1-30 Legionella pneumophila strain Corby-08 Zymomonas mobilis subsp. mobilis strain NCIMB 11163-08 Rhizobium leguminosarum bv. trifolii strain WSM2304-30 Parabacteroides distasonis strain ATCC 8503-08 cyanobacterium UCYN-A-08 Bradyrhizobium sp. BTAi1-08 Caulobacter segnis strain ATCC 21756-30 Xylella fastidiosa 9a5c-08For Peer Review Only Anaplasma marginale subsp. centrale str. Israel-30 Haemophilus influenzae Rd KW20-08 Bacteroides thetaiotaomicron strain VPI-5482-30 Granulobacter bethesdensis CGDNIH1-01 Shewanella violacea strain DSS12-01 Legionella pneumophila str. Paris-30 Pseudomonas entomophila strain L48-01 Minibacterium massiliensis-08 Archaeoglobus fulgidus strain VC-16-30 Pseudomonas aeruginosa str. UCBPP-PA14-01 Acidovorax sp. JS42-08 Streptococcus mutans str. UA159-30 Acidimicrobium ferrooxidans strain DSM 10331-08 Yersinia pseudotuberculosis strain IP 31758-30 Sphingomonas wittichii strain RW1-08 Rickettsia prowazekii strain Madrid E-08 Methylobacterium nodulans strain ORS 2060-08 Geodermatophilus obscurus strain DSM 43160-30 Candidatus Sulcia muelleri strain GWSS-30 Chlorobium phaeobacteroides strain BS1-08 Coxiella burnetii strain CbuK_Q154-08 Streptococcus suis strain BM407-30 Bradyrhizobium sp. ORS278-30 Chlorobium chlorochromatii strain CaD3-08 Corynebacterium diphtheriae NCTC13129-30 uncultured methanogenic archaeon Rice Cluster I-30 Paramecium bursaria Chlorella virus PBCV-1-08 Pyrobaculum calidifontis strain JCM 11548-30 Rickettsia typhi str. Wilmington-30 Candidatus Sulcia muelleri strain DMIN-01 Acinetobacter baumannii strain AB307-0294-08 Methylobacterium nodulans strain ORS 2060-30 Legionella pneumophila subsp. pneumophila strain Philadelphia 1-30 Mycobacterium sp. KMS-30 Bacteroides vulgatus strain ATCC 8482-08 Geobacillus sp. WCH70-30

Wiley-Blackwell and Society for Applied Microbiology Page 402 of 848

Chlorobium phaeobacteroides strain DSM 266-30 Arcobacter butzleri strain RM4018-08 Methanococcus jannaschii DSM 2661-30 Rickettsia felis strain URRWXCal2-08 Bordetella petrii strain DSM 12804-08 Acinetobacter baumannii strain ACICU-30 Prosthecochloris vibrioformis DSM 265-08 Bartonella bacilliformis strain KC583-30 Bordetella avium strain 197N-30 Rhizobium etli strain CIAT 652-08 Stenotrophomonas Formaltophilia strainPeer K279a-08 Review Only Beijerinckia indica subsp. indica strain ATCC 9039-08 Chlorobium chlorochromatii strain CaD3-30 Comamonas testosteroni strain CNB-2-08 Methanobrevibacter ruminantium strain M1-30 Pseudomonas sp. strain ADP-01 Francisella tularensis subsp. novicida U112-01 Wautersia metallidurans CH34-08 Micrococcus luteus strain NCTC 2665-30 Pseudomonas aeruginosa strain PA7-01 Burkholderia sp. CCGE1002-08 Enterobacter sakazakii ATCC BAA-894-08 Verrucomicrobiae bacterium V4-08 Enterobacter sp. 638-08 Pyrococcus sp. OT3-30 Rickettsia typhi str. Wilmington-08 Thiobacillus denitrificans strain ATCC 25259-01 Shewanella woodyi strain ATCC 51908-01 Yersinia pestis strain Z176003-30 Rhizobium leguminosarum bv. trifolii strain WSM1325-30 Streptococcus equi subsp. zooepidemicus strain MGCS10565-30 Nitrosomonas europaea str. ATCC 19718-01 Halomicrobium mukohataei strain DSM 12286-30 Kytococcus sedentarius strain DSM 20547-30 Pelodictyon luteolum DSM 273-08 Francisella tularensis subsp. tularensis strain WY96-3418-08 Ralstonia pickettii strain 12J-08 Brucella suis str. 1330-30 Pseudobacterium sepedonicum-30 Pelobacter propionicus strain DSM 2379-30 sulfate-reducing bacterium Hxd3-30 Brucella suis strain ATCC 23445-30 Bordetella parapertussis strain 12822-30 Acidiphilum cryptum JF-5-08 Acidiphilum cryptum JF-5-30 Pelodictyon phaeoclathratiforme strain BU-1-08 Buchnera aphidicola strain 5A (Acyrthosiphon pisum)-01

Wiley-Blackwell and Society for Applied Microbiology Page 403 of 848

Clostridium cellulolyticum strain H10-30 Wolinella succinogenes strain DSM 1740-30 Citrobacter rodentium strain ICC168-08 Clavibacter michiganensis subsp. michiganensis strain NCPPB 382-30 Bartonella grahamii strain as4aup-30 Oligotropha carboxidovorans strain OM5-08 Verminephrobacter eiseniae strain EF01-2-30 Pectobacterium carotovora subsp. atroseptica str. SCRI1043-08 Neisseria meningitidis serogroup A strain Z2491-30 Thermococcus gammatolerans strain EJ3-30 Pseudomonas putidaFor strain W619-01 Peer Review Only Pectobacterium carotovorum subsp. carotovorum strain PC1-30 Wautersia taiwanensis (Chen et al. 2001) Vaneechoutte et al. 2004-08 Halorhodospira halophila strain SL1-01 Pectobacterium wasabiae strain WPP163-30 Prochlorococcus sp. MIT9312-08 Diaphorobacter sp. TPSY-08 Pectobacterium wasabiae strain WPP163-08 Erwinia pyrifoliae strain Ep1/96-30 Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130-30 Rhodopseudomonas palustris strain CGA009-30 Bacteroides fragilis strain YCH46-08 Streptococcus pneumoniae strain 70585-30 Francisella tularensis subsp. mediasiatica strain FSC147-08 Erwinia amylovora strain ATCC 49946-30 Buchnera aphidicola str. Bp (Baizongia pistaciae)-08 Cenarchaeum symbiosum B-01 Chloroflexus aurantiacus strain J-10-fl-30 Ehrlichia chaffeensis str. Arkansas-08 Bartonella quintana strain Toulouse-30 Meiothermus ruber strain DSM 1279-08 Actinobacillus pleuropneumoniae strain L20-08 Bacillus thuringiensis strain Al Hakam-30 Actinobacillus pleuropneumoniae serovar 3 str. JL03-08 Brucella suis strain ATCC 23445-08 Gloeobacter violaceus strain PCC 7421-08 Sulfurovum sp. NBC37-1-08 Klebsiella variicola strain At-22-30 Methylobacterium radiotolerans strain JCM 2831-08 Bartonella bacilliformis strain KC583-01 Meiothermus ruber strain DSM 1279-30 Yersinia pseudotuberculosis strain PB1/+-08 Streptomyces avermitilis str. MA-4680-30 Acidovorax citrulli strain AAC00-1-08 Methylocella sp. BL2-08 Dickeya dadantii strain Ech586-08 Francisella philomiragia subsp. philomiragia strain ATCC 25017-01

Wiley-Blackwell and Society for Applied Microbiology Page 404 of 848

Propionibacterium acnes strain KPA171202-08 Frankia sp. EAN1pec-30 Xanthomonas albilineans var. paspali-08 Wolbachia sp. wRi-08 Pseudomonas fluorescens strain Pf-5-01 Pseudomonas fluorescens str. SBW25-01 Psychrobacter sp. PRwf-1-01 Prosthecochloris aestuarii strain DSM 271-08 Pyrobaculum aerophilum strain IM2-30 Wautersia taiwanensis (Chen et al. 2001) Vaneechoutte et al. 2004-30 Brucella melitensis strainFor ATCC 23457-30Peer Review Only Erwinia tasmaniensis strain Et1/99-08 Brucella canis strain ATCC 23365-30 Neisseria meningitidis serogroup B strain MC58-08 Azospirillum sp. B510-01 Jonesia denitrificans strain DSM 20603-30 Xylella fastidiosa strain M23-08 Neisseria gonorrhoeae strain NCCP11945-08 Gluconacetobacter diazotrophicus strain PAl 5-30 Acidimicrobium ferrooxidans strain DSM 10331-01 Pseudomonas fluorescens strain Pf0-1-01 Bacillus megaterium strain DSM319-30 Chloroherpeton thalassium strain ATCC 35110-08 Methylobacterium sp. 4-46-30 Pseudomonas syringae pv. syringae strain B728a-01 Salinibacter ruber strain DSM 13855-30 Pseudomonas putida str. KT2440-01 Rhizobium radiobacter str. C58 (U. Washington)-01 Pseudomonas putida GB-1-01 Rubrivivax gelatinosus PM1-01 Shewanella pealeana strain ATCC 700345-01 Sodalis glossinidius strain 'morsitans'-30 Acidovorax sp. JS42-30 Conexibacter woesei strain DSM 14684-30 Pseudomonas putida strain F1-01 Burkholderia thailandensis strain E264-30 Xylella fastidiosa str. Temecula1-08 Treponema denticola str. ATCC 35405-30 Francisella tularensis subsp. holarctica strain OSU18-30 Beutenbergia cavernae strain DSM 12333-30 Desulfovibrio salexigens strain DSM 2638-08 Sulfurospirillum deleyianum strain DSM 6946-30 Deinococcus geothermalis strain DSM 11300-30 Enterobacter sp. 638-30 Rhodothermus marinus strain DSM 4252-01 Burkholderia sp. 383-08 Prevotella ruminicola strain 23-08

Wiley-Blackwell and Society for Applied Microbiology Page 405 of 848

Desulfohalobium retbaense strain DSM 5692-08 Yersinia pseudotuberculosis strain YPIII-30 Pseudomonas syringae pv. phaseolicola strain 1448A-01 Dichelobacter nodosus str. VCS1703A-01 Staphylococcus aureus subsp. aureus Mu50-30 Streptococcus mitis strain B6-08 Thermobifida fusca strain YX-30 Desulfobacterium autotrophicum strain HRM2-08 Frankia sp. CcI3-30 Salmonella enterica subsp. enterica serovar Typhi str. Ty2-08 Nitrosomonas eutrophaFor strain C91-01Peer Review Only Burkholderia cepacia str. J2315-30 Tolumonas auensis strain DSM 9187-01 Acinetobacter sp. ADP1-01 Sodalis glossinidius strain 'morsitans'-08 Neisseria meningitidis serogroup A strain Z2491-08 Corynebacterium kroppenstedtii strain DSM 44385-30 Synechococcus sp. strain RF-1-08 Phenylobacterium zucineum strain HLK1-08 Salinibacter ruber Anton et al. 2002-30 Symbiobacterium thermophilum strain IAM 14863-30 Delftia acidovorans strain SPH-1-08 Klebsiella pneumoniae strain NTUH-K2044-30 Shigella flexneri serotype 2a str. 301-08 Maricaulis maris strain MCS10-01 Pseudomonas aeruginosa strain LESB58-01 Aciduliprofundum boonei strain T469-08 Escherichia coli strain CFT073-30 Sphaerobacter thermophilus strain DSM 20745-30 Buchnera aphidicola str. Cc (Cinara cedri)-01 Candidatus Hamiltonella defensa strain 5AT (Acyrthosiphon pisum)-08 Deinococcus radiodurans str. R1-08 Frankia alni strain ACN14a-30 Lysinibacillus sphaericus strain C3-41-08 Thermosynechococcus elongatus strain BP-1-01 Bacillus cereus strain ATCC 10987-30 Wolinella succinogenes strain DSM 1740-08 Acidiphilum cryptum JF-5-01 Nostoc sp. strain PCC 7120-08 Citrobacter koseri strain ATCC BAA-895-08 Dickeya zeae strain Ech1591-08 Rhizobium leguminosarum bv. trifolii strain WSM1325-08 Mesorhizobium loti strain MAFF303099-01 Shewanella sp. PV-4-01 Shewanella sp. WP3-01 Burkholderia glumae strain BGR1-08 Chlorobium limicola strain DSM 245-08

Wiley-Blackwell and Society for Applied Microbiology Page 406 of 848

Pseudomonas syringae pv. tomato str. DC3000-01 Shewanella sediminis strain HAW-EB3-01 Ralstonia solanacearum strain MolK2-30 Xanthomonas euvesicatoria str. 85-10-30 Xanthomonas oryzae pv. oryzae strain MAFF 311018-30 Rhizobium leguminosarum bv. viciae str. 3841-08 Clostridium tetani str. E88-30 Desulfatibacillum alkenivorans strain AK-01-30 Bradyrhizobium sp. ORS278-08 Bifidobacterium longum str. NCC2705-30 Gemmatimonas aurantiacaFor strain Peer T-27-08 Review Only Brucella abortus bv. 1 strain 9-941-08 Baumannia cicadellinicola str. Hc (Homalodisca coagulata)-08 Bacillus amyloliquefaciens strain FZB42-30 Pelobacter propionicus strain DSM 2379-08 Klebsiella variicola strain At-22-08 Vibrio cholerae strain M66-2-08 Rhizobium leguminosarum bv. trifolii strain WSM2304-08 Streptococcus suis strain 98HAH33-30 Buchnera aphidicola str. Bp (Baizongia pistaciae)-01 Rhodopseudomonas palustris strain BisB18-08 Yersinia pseudotuberculosis strain IP 31758-08 Photorhabdus asymbiotica Fischer-Le Saux et al. 1999 emend. Akhurst et al. 2004-08 Pasteurella multocida subsp. multocida strain Pm70-01 Bacteroides thetaiotaomicron strain VPI-5482-08 Rhodopseudomonas palustris strain TIE-1-30 Cyanothece sp. BH68K-08 Nocardioides sp. JS614-30 bacterium Ellin6076-30 Methylobacterium sp. 4-46-08 Ralstonia pickettii strain 12D-30 Yersinia pestis strain Antiqua-08 Salmonella enterica subsp. enterica serovar Typhi str. Ty2-30 Legionella pneumophila str. Lens-30 Anaplasma marginale strain St. Maries-08 Escherichia coli strain CFT073-08 Coxiella burnetii strain RSA 331-01 Sulfurospirillum deleyianum strain DSM 6946-08 Zymomonas mobilis subsp. mobilis strain ZM4-30 Petrotoga mobilis strain SJ95-30 Rhodopseudomonas palustris strain CGA009-08 Coxiella burnetii strain CbuG_Q212-01 Rickettsia massiliae strain MTU5-08 Burkholderia vietnamiensis strain G4-08 Candidatus Riesia pediculicola USDA-01 Hydrogenobacter thermophilus strain TK-6-30 Aeromonas hydrophila subsp. hydrophila strain ATCC 7966-01

Wiley-Blackwell and Society for Applied Microbiology Page 407 of 848

Geobacillus kaustophilus HTA426-30 Streptococcus pneumoniae strain P1031-30 Synechococcus sp. RF-2-08 Buchnera aphidicola str. Sg (Schizaphis graminum)-01 Vibrio sp. Ex25-01 Rickettsia canadensis strain McKiel-30 Methanocorpusculum labreanum strain Z-30 Synechococcus sp. WH8102-01 Methylobacterium sp. DM4-30 Francisella tularensis subsp. tularensis strain WY96-3418-30 Ehrlichia ruminantiumFor strain Gardel-30 Peer Review Only Coxiella burnetii strain RSA 331-08 Desulfovibrio salexigens strain DSM 2638-30 Coxiella burnetii str. RSA 493-08 Bartonella grahamii strain as4aup-08 Shigella flexneri serotype 2a str. 2457T-08 Legionella pneumophila strain Corby-30 Hirschia baltica strain ATCC 49814-01 Haemophilus influenzae strain 86-028NP-08 Dyadobacter fermentans strain DSM 18053-01 Psychrobacter sp. 273-4-01 Deferribacter desulfuricans strain SSM1-08 Rhodococcus sp. RHA1-30 Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130-08 Coxiella burnetii strain CbuK_Q154-01 Anaeromyxobacter sp. K-30 deep-sea eubacterium SS9-01 Acidobacterium capsulatum strain ATCC 51196-30 Acinetobacter baumannii strain AYE-08 Deinococcus deserti strain VCD115-08 Xanthomonas campestris pv. campestris strain B100-08 Nostoc sp. PCC 7937-08 Geobacter lovleyi strain SZ-08 Laribacter hongkongensis strain HLHK9-01 Rickettsia bellii strain RML369-C-01 Candidatus Liberibacter asiaticus strain psy62-30 Salmonella typhimurium LT2-30 Denitrovibrio acetiphilus strain DSM 12809-08 Helicobacter pylori strain HPAG1-30 Acaryochloris marina MBIC11017-08 Hyphomonas neptunium strain ATCC 15444-01 Clostridium sp. OhILAs-08 Ralstonia solanacearum strain MolK2-08 Rhizobium leguminosarum bv. viciae str. 3841-30 Desulfotomaculum acetoxidans strain DSM 771-30 Sulfurihydrogenibium azorense strain Az-Fu1-08 Sinorhizobium medicae WSM419-01

Wiley-Blackwell and Society for Applied Microbiology Page 408 of 848

Brucella melitensis str. ATCC 23456-08 Bartonella quintana strain Toulouse-01 Kribbella flavida strain DSM 17836-30 Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578-08 Picrophilus torridus strain DSM 9790-08 Erwinia amylovora strain CFBP1430-30 Rhodopseudomonas palustris strain BisB5-08 Acidovorax citrulli strain AAC00-1-30 Shewanella frigidimarina strain NCIMB 400-01 Burkholderia cepacia str. J2315-08 Acidothermus cellulolyticusFor strain Peer 11B-08 Review Only Geobacter sp. M21-08 Thermodesulfovibrio yellowstonii DSM 11347-08 Brucella abortus bv. 1 strain 9-941-30 Xanthomonas euvesicatoria str. 85-10-08 Rickettsia canadensis strain McKiel-08 Mycobacterium gilvum strain PYR-GCK-30 Brucella sp. CCM 4915-01 Zymomonas mobilis subsp. mobilis strain NCIMB 11163-01 Vibrio salmonicida LFI1238-01 Geobacter sp. FRC-32-30 Clostridium perfringens strain SM101-30 Thermococcus sibiricus strain MM 739-08 Chlorobaculum parvum strain NCIB 8327-08 Desulfotomaculum reducens strain MI-1-30 Orientia tsutsugamushi strain Boryong-30 Synechococcus sp. CC9605-01 Xanthomonas axonopodis pv. citri str. 306-08 Legionella longbeachae strain NSW150-01 Gluconacetobacter diazotrophicus strain PAl 5-08 Aeromonas salmonicida subsp. salmonicida strain A449-01 Vibrio parahaemolyticus str. RIMD 2210633-01 Neisseria meningitidis strain 053442-08 Arthrobacter chlorophenolicus strain A6-30 Catenulispora acidiphila strain DSM 44928-30 Nitratiruptor sp. SB155-2-08 Elusimicrobium minutum strain Pei191-30 Caulobacter segnis strain ATCC 21756-08 Clostridium novyi-NT-30 Arthrobacter sp. FB24-30 Thiomicrospira denitrificans ATCC 33889-08 Bacteroides fragilis strain NCTC 9343-08 Methylobacterium extorquens strain PA1-30 Caulobacter vibrioides CB15-30 Cloacamonas acidaminovorans-08 Salmonella enterica subsp. enterica serovar Heidelberg str. SL476-08 sulfate-reducing bacterium Hxd3-08

Wiley-Blackwell and Society for Applied Microbiology Page 409 of 848

Klebsiella pneumoniae strain NTUH-K2044-08 Acidaminococcus fermentans strain DSM 20731-08 Herminiimonas arsenicoxydans Muller et al. 2006-01 Ralstonia solanacearum strain GMI1000-08 Escherichia fergusonii strain ATCC 35469-08 Carboxydothermus hydrogenoformans str. Z-2901-08 Bordetella bronchiseptica RB50-30 Eggerthella lenta strain DSM 2243-30 Shewanella halifaxensis strain HAW-EB4-01 Rhodococcus opacus strain B4-30 Leptospirillum ferrooxidansFor ATCC Peer 53993-08 Review Only Pseudomonas sp. LB400-08 Desulfotalea psychrophila LSv54-01 Pirellula staleyi strain DSM 6068-01 Micrococcus luteus ATCC 9341-08 Klebsiella pneumoniae strain 342-08 Shewanella denitrificans strain OS217-01 Coxiella burnetii strain Dugway 5J108-111-01 Finegoldia magna strain ATCC 29328-30 Buchnera aphidicola str. Sg (Schizaphis graminum)-30 Hydrogenobaculum sp. Y04AAS1-08 Rhodopseudomonas palustris strain TIE-1-08 Haemophilus influenzae strain PittGG-01 Haemophilus influenzae strain 86-028NP-01 Thermosipho melanesiensis strain BI429-30 Alicyclobacillus acidocaldarius subsp. acidocaldarius strain DSM 446-30 Oligotropha carboxidovorans strain OM5-01 Xanthomonas oryzae pv. oryzae strain PXO99A-08 [Mesorhizobium] sp. BNC1-01 Xanthomonas sp. Py2-01 Xylella fastidiosa strain M12-08 Mycobacterium smegmatis strain MC2 155-30 Rhodopseudomonas palustris strain BisA53-08 Alkaliphilus metalliredigens strain QYMF-08 Mycobacterium abscessus strain ATCC 19977-08 Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2-01 Thermanaerovibrio acidaminovorans strain DSM 6589-08 Escherichia coli O26:H11 strain 11368-30 Thermodesulfovibrio yellowstonii DSM 11347-30 Rhodococcus sp. RHA1-08 Paenibacillus sp. JDR-2-30 Arthrobacter aurescens strain TC1-08 Rhodococcus erythropolis strain PR4-30 Desulfovibrio vulgaris vulgaris (strain Hildenborough)-30 Synechococcus sp. PCC 7424-08 Vibrio cholerae serotype O1 biotype ElTor strain N16961-01 Psychrobacter cryohalolentis strain K5-01

Wiley-Blackwell and Society for Applied Microbiology Page 410 of 848

endosymbiont of Acanthamoeba sp. UWE25-08 Kineococcus-like str. SRS30216-30 Myxococcus xanthus strain DK 1622-30 Actinobacillus succinogenes strain 130Z-01 Brucella melitensis strain ATCC 23457-08 Geobacter metallireducens strain GS-15-08 Caulobacter sp. K31-08 Rhodopseudomonas palustris strain HaA2-08 Synechococcus sp. RCC307-01 Salmonella enterica subsp. enterica serovar Enteritidis strain P125109-30 Polynucleobacter sp.For QLW-P1DMWA-1-01 Peer Review Only Hyperthermus butylicus strain DSM 5456-30 Vibrio fischeri strain MJ11-01 Natrialba magadii strain ATCC 43099-08 Geobacter sulfurreducens strain PCA-30 Synechococcus sp. PCC7002-01 Yersinia pestis strain Pestoides F-08 uncultured methanogenic archaeon Rice Cluster I-08 Streptococcus pneumoniae strain ATCC 700669-30 Sphingopyxis alaskensis strain RB2256-01 Erwinia amylovora strain ATCC 49946-08 Rhodopirellula baltica strain SH 1-01 Porphyromonas gingivalis strain W83-01 Methylobacterium sp. CM4-30 Corynebacterium urealyticum strain DSM 7109-30 Vibrio cholerae strain MJ-1236-01 Xanthomonas campestris pv. campestris str. ATCC 33913-08 Desulfitobacterium sp. Y51-30 Arcobacter butzleri strain RM4018-30 Vibrio harveyi strain ATCC BAA-1116-01 Roseiflexus castenholzii strain DSM 13941-08 Deinococcus deserti strain VCD115-30 Acidithiobacillus ferrooxidans str. ATCC 23270-01 Neisseria meningitidis strain FAM18-08 Ochrobactrum anthropi strain ATCC 49188-01 Syntrophobacter fumaroxidans strain MPOB-30 Wolbachia sp. wRi-01 Haemophilus parasuis strain SH0165-01 Histophilus somni str. 2336-01 Mycobacterium marinum strain M-30 Candidatus Blochmannia pennsylvanicus strain BPEN-08 Brucella melitensis biovar Abortus strain 2308-30 Trichodesmium sp. IMS101-01 Candidatus Amoebophilus asiaticus strain 5a2-01 Bdellovibrio bacteriovorus strain HD100-08 Pelotomaculum thermopropionicum strain SI-30 Ehrlichia canis strain Jake-30

Wiley-Blackwell and Society for Applied Microbiology Page 411 of 848

Spirosoma linguale strain DSM 74-01 Bacillus megaterium strain QM B1551-30 Brucella suis str. 1330-08 Nitrobacter winogradskyi strain Nb-255-01 Xanthomonas oryzae pv. oryzae strain MAFF 311018-08 Leptospirillum ferrooxidans ATCC 53993-01 Listeria monocytogenes strain 08-5923-30 Burkholderia cepacia AMMD-08 Rhodococcus opacus strain B4-08 Burkholderia sp. STM815-08 Stackebrandtia nassauensisFor strain Peer DSM 44728-08 Review Only Yersinia pestis strain Nepal516-30 Yersinia pestis strain Nepal516-08 Thauera sp. MZ1T-01 Desulfovibrio vulgaris strain 'Miyazaki F'-30 Methanocaldococcus vulcanius strain M7-30 Staphylococcus carnosus subsp. carnosusstrain TM300-30 Beijerinckia indica subsp. indica strain ATCC 9039-01 Brucella canis strain ATCC 23365-01 Dechloromonas sp. RCB-01 Nostoc sp. PCC73102-08 Desulfatibacillum alkenivorans strain AK-01-08 Baumannia cicadellinicola str. Hc (Homalodisca coagulata)-01 Acetobacter pasteurianus IFO 3283-01-01 Acinetobacter baumannii strain SDF-01 Lactobacillus brevis strain ATCC 367-30 Acinetobacter baumannii strain AYE-01 Leptospira interrogans serovar Lai str. 56601-30 Methanococcoides burtonii str. DSM 6242-30 Brucella suis strain ATCC 23445-01 Caulobacter vibrioides CB15-01 Rhizobium sp. NGR234-01 Rhizobium sp. ORS571-01 Streptococcus gallolyticus strain UCN34-30 Sinorhizobium meliloti strain 1021-01 Bartonella tribocorum strain CIP 105476-08 Escherichia coli strain ED1a-08 Burkholderia pseudomallei strain 668-08 Burkholderia sp. PsJN-08 Exiguobacterium sp. AT1b-30 Salmonella enterica subsp. enterica serovar Gallinarum strain 287/91-30 Atopobium parvulum strain DSM 20469-08 Jonesia denitrificans strain DSM 20603-08 Novosphingobium aromaticivorans strain DSM 12444-01 Burkholderia pseudomallei strain 1106a-08 Salinospora sp. CNB440-30 Caulobacter crescentus strain NA1000-01

Wiley-Blackwell and Society for Applied Microbiology Page 412 of 848

Yersinia pestis strain Antiqua-30 Leptospira interrogans serovar Lai str. 56601-08 Vibrio vulnificus str. YJ016-01 Francisella tularensis var. palaearctica-08 Burkholderia sp. STM815-30 Wautersia eutropha JMP134-01 Candidatus Accumulibactor phosphatis Type IIA str. UW-1-01 Rickettsia typhi str. Wilmington-01 Methanococcoides burtonii str. DSM 6242-08 Syntrophobacter fumaroxidans strain MPOB-08 Geobacter uraniumreducensFor Rf4-08 Peer Review Only Pelodictyon phaeoclathratiforme strain BU-1-01 Yersinia pestis strain KIM 10-30 Chitinophaga pinensis strain DSM 2588-01 Leptothrix cholodnii strain SP-6-01 Brucella melitensis biovar Abortus strain 2308-08 Bordetella pertussis Tohama I-08 Synechococcus sp. WH7803-01 Methylobacterium sp. DM4-08 Bifidobacterium longum str. DJO10A-30 Bifidobacterium longum subsp. infantis strain ATCC 15697-30 Bacillus halodurans strain C-125-08 Prochlorococcus marinus str. MIT 9515-01 Buchnera sp. APS-01 Staphylococcus haemolyticus strain JCSC1435-30 Deinococcus geothermalis strain DSM 11300-08 Streptomyces avermitilis str. MA-4680-08 Rhizobium etli strain CIAT 652-30 Zymomonas mobilis subsp. mobilis strain ZM4-01 Leptospirillum ferrooxidans ATCC 53993-30 Xanthomonas campestris pv. campestris strain 8004-08 Kribbella flavida strain DSM 17836-08 cyanobacterium UCYN-A-01 Desulfomicrobium baculatum strain DSM 4028-01 Pyrococcus abyssi strain GE5-30 Dictyoglomus thermophilum H-6-12-30 Agrobacterium vitis strain S4-01 Francisella tularensis subsp. holarctica strain OSU18-01 Vibrio vulnificus str. CMCP6-01 Burkholderia cenocepacia strain MC0-3-08 Streptosporangium roseum strain DSM 43021-30 Rickettsia massiliae strain MTU5-01 Yersinia pseudotuberculosis strain IP 32953-08 Rubrobacter xylanophilus strain DSM 9941-08 Aggregatibacter actinomycetemcomitans strain D11S-1-01 Thiomicrospira denitrificans ATCC 33889-01 Clostridium botulinum A2 strain Kyoto-30

Wiley-Blackwell and Society for Applied Microbiology Page 413 of 848

Mycobacterium avium subsp. paratuberculosis strain K-10-30 Sorangium cellulosum strain 'So ce 56'-08 Synechococcus sp. PCC6301-01 Elusimicrobium minutum strain Pei191-08 Borrelia afzelii strain PKo-30 Paenibacillus sp. JDR-2-08 Rickettsia prowazekii strain Madrid E-01 Legionella pneumophila subsp. pneumophila strain Philadelphia 1-01 Mannheimia succiniciproducens str. MBEL55E-01 Rickettsia bellii strain OSU 85-389-01 Bordetella petrii strainFor DSM 12804-01 Peer Review Only Rhizobium radiobacter K84-01 Yersinia pestis strain CO92-30 Listeria monocytogenes strain Clip80459-08 Saccharomonospora viridis strain DSM 43017-08 Bartonella grahamii strain as4aup-01 Lawsonia intracellularis strain PHE/MN1-00-30 Xanthomonas oryzae pv. oryzae strain KACC10331-08 Caldicellulosiruptor saccharolyticus strain DSM 8903-30 Porphyromonas gingivalis strain ATCC 33277-01 Rhodoferax ferrireducens strain T118-01 Streptococcus suis strain SC84-08 Geobacillus thermodenitrificans strain NG80-2-08 Clostridium perfringens strain ATCC 13124-30 Legionella pneumophila strain Corby-01 Methylobacterium sp. BJ001-08 Anaplasma marginale subsp. centrale str. Israel-08 Brucella suis str. 1330-01 Bordetella bronchiseptica RB50-08 Haemophilus influenzae strain PittEE-01 Bordetella parapertussis strain 12822-08 Verminephrobacter eiseniae strain EF01-2-01 Buchnera aphidicola strain Tuc7 (Acyrthosiphon pisum)-01 Sinorhizobium meliloti (Dangeard 1926) De Lajudie et al. 1994-01 Burkholderia cenocepacia HI2424-08 Salmonella enterica subsp. enterica serovar Paratyphi B strain SPB7-30 Brucella melitensis str. ATCC 23456-30 Chloroflexus aggregans strain DSM 9485-08 Candidatus Liberibacter asiaticus strain psy62-01 Escherichia coli strain BL21(DE3)-08 Haemophilus ducreyi str. 35000HP-01 Sphaerobacter thermophilus strain DSM 20745-08 Francisella tularensis subsp. holarctica strain FTNF002-00-30 Chromobacterium violaceum str. ATCC 12472-01 Shewanella sp. W3-18-1-01 Escherichia coli O55:H7 strain CB9615-30 Orientia tsutsugamushi strain Boryong-08

Wiley-Blackwell and Society for Applied Microbiology Page 414 of 848

Legionella pneumophila str. Paris-01 Methanosarcina acetivorans str. C2A-30 Nocardia farcinica strain IFM 10152-30 Sulfurospirillum deleyianum strain DSM 6946-01 Prosthecochloris aestuarii strain DSM 271-01 Burkholderia cenocepacia AU 1054-08 Xanthomonas oryzae pv. oryzae strain KACC10331-30 Desulfotomaculum reducens strain MI-1-08 Corynebacterium nigricans CN-1-08 Acinetobacter baumannii strain AB0057-01 Halothermothrix oreniiFor strain H 168-08Peer Review Only Escherichia coli strain ED1a-30 Halobacterium sp. NRC-1-30 Clostridium perfringens str. 13-08 Gluconobacter oxydans strain 621H-01 Pseudomonas sp. AM1-30 Pseudomonas multivorans-01 Rhizobium leguminosarum bv. trifolii strain WSM2304-01 Neisseria meningitidis serogroup B strain MC58-01 Geobacter bemidjiensis strain Bem-08 Burkholderia thailandensis strain E264-08 Conexibacter woesei strain DSM 14684-08 Desulfitobacterium hafniense DSM 10664-30 Salmonella paratyphi C strain RKS4594-08 Parabacteroides distasonis strain ATCC 8503-01 Francisella tularensis subsp. mediasiatica strain FSC147-01 Polynucleobacter necessarius subsp. necessarius strain STIR1-01 Legionella pneumophila str. Lens-01 Prochlorococcus sp. MIT9215-01 Thermobifida fusca strain YX-08 Desulfovibrio desulfuricans subsp. desulfuricans strain ATCC 27774-30 Leptospira biflexa serovar Patoc strain Paris-30 Clavibacter michiganensis subsp. michiganensis strain NCPPB 382-08 Ralstonia solanacearum strain IPO1609-08 Pelodictyon phaeoclathratiforme strain BU-1-30 Streptococcus thermophilus strain LMD-9-08 Streptomyces scabies 87.22-30 Leptospira biflexa serovar Patoc strain Patoc1-08 Chloroflexus sp. Y-400-fl-08 Methanosphaera stadtmanae strain DSM 3091-08 Yersinia pestis strain Z176003-08 bacterium Ellin345-30 Desulfovibrio desulfuricans subsp. desulfuricans strain ATCC 27774-08 Ehrlichia chaffeensis str. Arkansas-01 Desulfovibrio vulgaris subsp. vulgaris DP4-30 Actinobacillus pleuropneumoniae serovar 7 strain AP76-01 Thermus thermophilus HB8-30

Wiley-Blackwell and Society for Applied Microbiology Page 415 of 848

Candidatus Hamiltonella defensa strain 5AT (Acyrthosiphon pisum)-01 Picrophilus torridus strain DSM 9790-30 Bacillus cereus strain 03BB102-30 Burkholderia mallei str. ATCC 23344-08 Thermus thermophilus strain HB27-30 Arthrobacter chlorophenolicus strain A6-08 Brucella ovis strain ATCC 25840-01 Candidatus Blochmannia floridanus-01 Syntrophus aciditrophicus strain SB-08 Rickettsia massiliae strain MTU5-30 Escherichia coli O55:H7For strain CB9615-08 Peer Review Only Geobacillus kaustophilus HTA426-08 Clostridium beijerinckii strain NCIMB 8052-30 Sphingomonas aromaticivorans Balkwill et al. 1997-01 Geobacter bemidjiensis strain Bem-30 Clostridium thermocellum strain ATCC 27405-08 Azoarcus sp. EbN1-01 Neisseria gonorrhoeae strain FA 1090-08 Bartonella tribocorum strain CIP 105476-01 Francisella tularensis subsp. tularensis strain FSC198-08 Geodermatophilus obscurus strain DSM 43160-08 Proteus mirabilis strain HI4320-01 Acinetobacter baumannii strain ACICU-01 Phenylobacterium zucineum strain HLK1-01 Nocardioides sp. JS614-08 Haemophilus influenzae Rd KW20-01 Leptospira biflexa serovar Patoc strain Paris-08 Anaeromyxobacter dehalogenans strain 2CP-1-08 Chlorobium phaeobacteroides strain DSM 266-08 Geodermatophilus obscurus strain DSM 43160-01 Pseudobacterium sepedonicum-08 Kytococcus sedentarius strain DSM 20547-08 Mycobacterium ulcerans strain Agy99-30 Helicobacter hepaticus str. ATCC 51449-30 Histophilus somni str. 129PT-01 Paramecium bursaria Chlorella virus PBCV-1-01 Escherichia coli IAI39-30 Arthrobacter sp. FB24-08 Clostridium sp. OhILAs-30 Neisseria meningitidis strain 053442-01 Bordetella avium strain 197N-01 Serratia proteamaculans strain 568-01 Sulfurihydrogenibium sp. YO3AOP1-08 Prochlorococcus sp. AS9601-01 Shewanella sp. MR-7-01 Mycobacterium marinum strain M-08 Sphingobium japonicum strain UT26S-01

Wiley-Blackwell and Society for Applied Microbiology Page 416 of 848

Thermotogales bacterium TBF 19.5.1-30 Rhodopseudomonas palustris strain BisB5-01 Geobacter sp. FRC-32-08 bacterium Ellin345-08 Francisella tularensis subsp. tularensis strain SCHU S4-01 Aggregatibacter aphrophilus strain NJ8700-01 Dictyoglomus turgidum strain DSM 6724-08 Anoxybacillus flavithermus strain WK1-30 Anaeromyxobacter dehalogenans strain 2CP-C-30 Actinosynnema mirum strain DSM 43827-30 Salmonella entericaFor subsp. enterica Peer serovar Paratyphi Review A strain AKU_12601-08 Only Ferroglobus placidus strain DSM 10642-08 Caulobacter segnis strain ATCC 21756-01 Burkholderia pseudomallei strain K96243-08 Methanohalophilus mahii strain DSM 5219-08 Salmonella enterica subsp. enterica serovar Paratyphi A strain AKU_12601-30 Clostridium novyi-NT-08 Thermobaculum terrenum strain ATCC BAA-798-08 Fibrobacter succinogenes subsp. succinogenes S85-08 Acidobacterium capsulatum strain ATCC 51196-08 Propionibacterium acnes strain SK137-01 Mycobacterium ulcerans strain Agy99-08 Bacillus subtilis subsp. subtilis str. BGSC 1A700-30 Vibrio cholerae strain O395-01 Halorubrum lacusprofundi strain ATCC 49239-30 Rhodococcus erythropolis strain PR4-08 Ralstonia pickettii strain 12D-01 Methylobacterium extorquens strain PA1-08 Edwardsiella tarda strain EIB202-01 Haliangium ochraceum strain DSM 14365-08 Chlorobium tepidum strain TLS-01 Rickettsia canadensis strain McKiel-01 Thermomonospora curvata strain DSM 43183-08 Vibrio fischeri strain ES114-01 Nocardia farcinica strain IFM 10152-08 Sulfurovum sp. NBC37-1-01 Xanthomonas albilineans var. paspali-01 Escherichia coli strain UTI89-30 Rickettsia africae ESF-5-01 Chlamydia trachomatis strain B/TZ1A828/OT-08 Neisseria meningitidis strain FAM18-01 Staphylococcus haemolyticus strain JCSC1435-08 Xenorhabdus bovienii strain SS-2004-01 Vibrio cholerae strain M66-2-30 Buchnera sp. APS-08 Candidatus Blochmannia floridanus-08 Renibacterium salmoninarum strain ATCC 33209-08

Wiley-Blackwell and Society for Applied Microbiology Page 417 of 848

Rickettsia peacockii strain Rustic-01 Francisella tularensis subsp. tularensis strain FSC198-01 Thermococcus kodakarensis strain KOD1-08 Anoxybacillus flavithermus strain WK1-01 Hydrogenobaculum sp. Y04AAS1-01 Azoarcus sp. BH72-01 Desulfovibrio desulfuricans subsp. desulfuricans strain G20-08 Nitratiruptor sp. SB155-2-30 Burkholderia pseudomallei strain MSHR346-08 Clostridium acetobutylicum strain ATCC 824-30 Wautersia metalliduransFor CH34-01 Peer Review Only Thermococcus kodakarensis strain KOD1-30 Salmonella enterica subsp. enterica serovar Paratyphi B strain SPB7-08 Salmonella enterica subsp. enterica serovar Enteritidis strain P125109-08 Chlorobaculum parvum strain NCIB 8327-01 Arcobacter butzleri strain RM4018-01 Geobacter sulfurreducens strain PCA-08 Escherichia fergusonii strain ATCC 35469-30 unidentified eubacterium-01 Escherichia coli IAI39-08 Escherichia coli O111:H- strain 11128-08 Rhizobium etli strain CFN 42-01 acidophilum strain DSM 1728-08 Coxiella burnetii str. RSA 493-01 Macrococcus caseolyticus strain JCSC5402-30 Brucella abortus strain S19-01 Akkermansia sp. Muc-01 Desulfitobacterium sp. Y51-08 Desulfovibrio vulgaris strain 'Miyazaki F'-08 Candidatus Liberibacter asiaticus strain psy62-08 Anaplasma marginale strain Florida-08 Sphingomonas wittichii strain RW1-01 Burkholderia mallei strain 10229-08 Pseudomonas sp. AM1-08 Edwardsiella ictaluri strain 93-146-01 Lactobacillus fermentum strain IFO 3956-08 Orientia tsutsugamushi strain Ikeda-08 Francisella tularensis subsp. tularensis strain FSC198-30 Methylocella sp. BL2-01 Salmonella enterica subsp. enterica serovar Agona str. SL483-08 Clostridium difficile strain R20291-08 Anoxybacillus flavithermus strain WK1-08 Shewanella sp. MR-1-01 Sebaldella termitidis strain ATCC 33386-08 Shewanella baltica strain OS155-01 Acidaminococcus fermentans strain DSM 20731-01 Shewanella baltica strain OS223-01

Wiley-Blackwell and Society for Applied Microbiology Page 418 of 848

Neisseria meningitidis strain alpha14-01 Anaeromyxobacter sp. K-08 Anaeromyxobacter sp. Fw109-5-08 Neisseria gonorrhoeae strain NCCP11945-01 Staphylococcus aureus subsp. aureus str. MW2-30 Escherichia coli O157:H7 EDL933-08 Caulobacter sp. K31-01 Shewanella sp. MR-4-01 Brucella melitensis strain ATCC 23457-01 Escherichia coli O157:H7 str. EC4115-08 Moorella thermoaceticaFor strain ATCCPeer 39073-08 Review Only Rhizobium leguminosarum bv. trifolii strain WSM1325-01 Erwinia pyrifoliae strain Ep1/96-01 Rickettsia africae ESF-5-08 Francisella tularensis subsp. tularensis strain WY96-3418-01 Yersinia enterocolitica subsp. enterocolitica strain 8081-01 Rickettsia felis strain URRWXCal2-01 Staphylococcus lugdunensis strain HKU09-01-30 Clostridium difficile strain CD196-08 Streptococcus zooepidemicus-08 Rhizobium etli strain CIAT 652-01 Methylobacterium sp. CM4-08 Myxococcus xanthus strain DK 1622-08 Thermomicrobium roseum DSM 5159-30 Bartonella henselae strain Houston-1-01 Acinetobacter baumannii strain ATCC 17978-01 Desulfovibrio vulgaris vulgaris (strain Hildenborough)-08 Synechocystis sp.PCC6803-01 Bacillus cytotoxis NVH 391-98-30 Synechocystis sp. PCC 7942-01 Geobacillus sp. Y412MC10-30 Thermocrinis albus strain DSM 14484-30 Bacteroides vulgatus strain ATCC 8482-01 Streptococcus suis strain 05ZYH33-08 Bradyrhizobium sp. BTAi1-01 Geobacillus sp. WCH70-01 Geobacillus sp. WCH70-08 Syntrophomonas wolfei subsp. wolfei strain Goettingen-08 Desulfotomaculum acetoxidans strain DSM 771-08 Neorickettsia risticii strain Illinois-01 Shewanella baltica strain OS185-01 Chloroherpeton thalassium strain ATCC 35110-01 bacterium EX-H1-08 Rickettsia akari strain Hartford-01 Desulfovibrio desulfuricans subsp. desulfuricans strain ATCC 27774-01 Prochlorococcus marinus str. NATL1A-01 Rickettsia rickettsii strain 'Sheila Smith'-08

Wiley-Blackwell and Society for Applied Microbiology Page 419 of 848

Pelotomaculum thermopropionicum strain SI-08 Variovorax paradoxus strain S110-01 Burkholderia ambifaria strain MC40-6-08 Chloroflexus aurantiacus strain J-10-fl-08 Minibacterium massiliensis-01 Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130-01 Candidatus Blochmannia pennsylvanicus strain BPEN-01 Rothia mucilaginosa strain DY-18-08 Alicyclobacillus acidocaldarius subsp. acidocaldarius strain DSM 446-08 Eggerthella lenta strain DSM 2243-08 Salmonella entericaFor subsp. enterica Peer serovar Choleraesuis Review strain SC-B67-30 Only Thermus thermophilus HB8-08 Escherichia coli UMN026-08 Dickeya dadantii strain Ech703-01 Shewanella putrefaciens strain CN-32-01 Comamonas testosteroni strain CNB-2-01 Methanothrix thermophila PT-08 Ralstonia solanacearum strain GMI1000-30 Anaerocellum thermophilum strain DSM 6725-30 Magnetococcus sp. MC-1-01 Wautersia taiwanensis (Chen et al. 2001) Vaneechoutte et al. 2004-01 Sulfurihydrogenibium sp. YO3AOP1-30 Prochlorococcus sp. MIT9312-01 Geobacillus thermodenitrificans strain NG80-2-01 Gemmatimonas aurantiaca strain T-27-01 Escherichia coli O127:H6 strain E2348/69-08 Salmonella enterica subsp. enterica serovar Gallinarum strain 287/91-08 Burkholderia mallei strain SAVP1-08 Desulfovibrio magneticus strain RS-1-30 Prochlorococcus marinus str. MIT 9301-01 Frankia sp. CcI3-08 Ammonifex degensii strain KC4-08 Eubacterium eligens strain ATCC 27750-08 Rhodopseudomonas palustris strain CGA009-01 bacterium Ellin6076-08 Erwinia tasmaniensis strain Et1/99-01 Rhodopseudomonas palustris strain HaA2-01 Pelobacter carbinolicus strain DSM 2380-01 Wautersia eutropha H16-01 Polaromonas sp. JS666-01 Corynebacterium jeikeium strain K411-08 Eubacterium eligens strain ATCC 27750-30 Synechococcus sp. PCC 7425-01 Bacillus cereus strain Q1-30 Clostridium botulinum E3 strain Alaska E43-30 Synechococcus sp. strain RF-1-01 Kineococcus-like str. SRS30216-08

Wiley-Blackwell and Society for Applied Microbiology Page 420 of 848

Polaromonas naphthalenivorans strain CJ2-01 Roseiflexus sp. strain RS-1-08 Shewanella trabarsenatis-01 Corynebacterium jeikeium strain K411-30 Micrococcus luteus strain NCTC 2665-08 Thermus thermophilus strain HB27-08 Carboxydothermus hydrogenoformans str. Z-2901-01 Methanospirillum hungatei strain JF-1-08 Bradyrhizobium japonicum str. USDA 110-01 Clostridium botulinum B strain Eklund 17B-08 Dehalococcoides sp.For GT-08 Peer Review Only Bifidobacterium lactis AD011-30 Yersinia pseudotuberculosis strain PB1/+-01 Beutenbergia cavernae strain DSM 12333-08 Salinibacter ruber Anton et al. 2002-08 Thermoanaerobacter tengcongensis strain MB4-08 Pectobacterium wasabiae strain WPP163-01 Saccharopolyspora erythraea strain NRRL 2338-08 Pediococcus pentosaceus strain ATCC 25745-08 Gordonia bronchialis strain DSM 43247-08 Shewanella baltica strain OS195-01 Nitratiruptor sp. SB155-2-01 Diaphorobacter sp. TPSY-01 Bacillus pumilus strain SAFR-032-30 Bradyrhizobium sp. ORS278-01 Leptospira borgpetersenii serovar Hardjo-bovis strain JB197-30 Saccharomonospora viridis strain DSM 43017-30 Cyanothece sp. BH68K-01 Rhodopseudomonas palustris strain BisA53-01 Burkholderia sp. STM815-01 Helicobacter pylori strain Shi470-08 Salinispora arenicola strain CNS-205-30 Ehrlichia canis strain Jake-01 Deinococcus geothermalis strain DSM 11300-01 Lactobacillus plantarum strain JDM1-30 strain GSS1-30 Rhodopseudomonas palustris strain BisB18-01 Listeria monocytogenes strain HCC23-08 Chlorobium phaeobacteroides strain BS1-01 Brevibacillus brevis strain NBRC 100599-08 Helicobacter hepaticus str. ATCC 51449-08 Prosthecochloris vibrioformis DSM 265-01 Exiguobacterium strain 255-15-08 bacterium CBDB1-08 Neisseria gonorrhoeae strain FA 1090-01 Pantoea ananatis strain LMG 20103-01 Streptomyces coelicolor A3(2)-30

Wiley-Blackwell and Society for Applied Microbiology Page 421 of 848

Methylobacterium nodulans strain ORS 2060-01 Desulfovibrio magneticus strain RS-1-08 Methanosarcina barkeri strain Fusaro-08 Methanosarcina mazei strain Go1-08 Synechococcus sp. OS-type A strain JA-3-3Ab-01 Rhodopseudomonas palustris strain TIE-1-01 Herpetosiphon aurantiacus DSM 785-08 Desulfovibrio vulgaris subsp. vulgaris DP4-08 Rhizobium leguminosarum bv. viciae str. 3841-01 Methylobacterium radiotolerans strain JCM 2831-01 Campylobacter lari strainFor RM2100-08 Peer Review Only korarchaeote OPF1-KOR-08 Mycobacterium avium str. 104-30 Rickettsia conorii strain Malish 7-08 Leptospira borgpetersenii serovar Hardjo-bovis strain JB197-08 Leptospira borgpetersenii serovar Hardjo-bovis strain L550-30 Acidothermus cellulolyticus strain 11B-01 Cronobacter turicensis z3032-01 Bdellovibrio bacteriovorus strain HD100-01 Bordetella pertussis Tohama I-01 Gordonia bronchialis strain DSM 43247-30 Neorickettsia sennetsu str. Miyayama-01 Helicobacter pylori strain G27-08 Petrotoga mobilis strain SJ95-08 Bacteroides fragilis strain YCH46-01 Clostridium perfringens strain ATCC 13124-08 Deferribacter desulfuricans strain SSM1-01 Bacillus tusciae strain DSM 2912-08 Corynebacterium glutamicum strain R-30 Eubacterium rectale strain ATCC 33656-08 Prochlorococcus sp. NATL2A-01 Xylella fastidiosa strain M12-01 Aquifex aeolicus str. VF5-08 Thermoplasma acidophilum strain DSM 1728-30 Geobacillus sp. Y412MC10-08 Desulfitobacterium hafniense DSM 10664-08 Lactococcus lactis subsp. lactis strain Il1403-30 Thermomicrobium roseum DSM 5159-08 Streptosporangium roseum strain DSM 43021-08 Clostridium perfringens str. 13-30 Enterobacter sp. 638-01 Chlorobium chlorochromatii strain CaD3-01 Haloquadratum walsbyi strain DSM 16790-08 Actinobacillus pleuropneumoniae serovar 3 str. JL03-01 Helicobacter hepaticus str. ATCC 51449-01 Aciduliprofundum boonei strain T469-01 Mycobacterium smegmatis strain MC2 155-08

Wiley-Blackwell and Society for Applied Microbiology Page 422 of 848

Leptospira biflexa serovar Patoc strain Patoc1-01 Brucella abortus strain S19-30 Bacillus amyloliquefaciens strain FZB42-08 Slackia heliotrinireducens strain DSM 20476-08 Geobacter lovleyi strain SZ-01 Nitrobacter hamburgensis strain X14-01 Propionibacterium acnes strain KPA171202-01 Macrococcus caseolyticus strain JCSC5402-08 Anaeromyxobacter dehalogenans strain 2CP-C-08 Rubrobacter xylanophilus strain DSM 9941-01 Treponema denticolaFor str. ATCC 35405-08Peer Review Only Clostridium difficile strain 630-08 Salinospora sp. CNB440-08 Bacteroides fragilis strain NCTC 9343-01 Gloeobacter violaceus strain PCC 7421-01 Heliobacterium modesticaldum strain Ice1-08 Cryptobacterium curtum strain DSM 15641-08 Verrucomicrobiales str. PB90-1-01 Methanocaldococcus fervens strain AG86-08 Streptococcus gordonii str. Challis substr. V288-30 Thermotoga sp. RKU-1-08 Clostridium phytofermentans strain ISDg-08 Neisseria meningitidis serogroup A strain Z2491-01 Methylobacterium sp. 4-46-01 Stenotrophomonas maltophilia strain K279a-01 Dickeya zeae strain Ech1591-01 Desulfobacterium autotrophicum strain HRM2-01 Frankia sp. EAN1pec-08 Mycobacterium tuberculosis strain KZN 1435-08 Xylanimonas cellulosilytica strain DSM 15894-08 Methylobacterium sp. BJ001-01 Anaeromyxobacter dehalogenans strain 2CP-1-30 Ralstonia solanacearum strain GMI1000-01 Bacillus pseudofirmus strain OF4-01 Bacillus sp. KSM-K16-08 Sanguibacter keddieii strain DSM 10542-08 Wolinella succinogenes strain DSM 1740-01 Exiguobacterium sp. AT1b-08 Natronomonas pharaonis strain DSM 2160-08 Xylella fastidiosa str. Temecula1-01 Burkholderia mallei strain NCTC 10247-08 Symbiobacterium thermophilum strain IAM 14863-08 Burkholderia sp. 383-01 Bacillus cytotoxis NVH 391-98-08 Prochlorococcus marinus subsp. marinus str. SS120-01 Bacillus megaterium strain QM B1551-08 Escherichia coli strain BW2952-08

Wiley-Blackwell and Society for Applied Microbiology Page 423 of 848

Mycobacterium tuberculosis strain F11-08 Xylella fastidiosa 9a5c-01 Burkholderia multivorans strain ATCC 17616-08 methanogenic archaeon strain SANAE-08 Listeria monocytogenes strain Clip80459-01 Burkholderia pseudomallei strain 1710b-08 Candidatus Riesia pediculicola USDA-08 Acidovorax citrulli strain AAC00-1-01 Brachybacterium faecium strain DSM 4810-08 Staphylococcus saprophyticus subsp. saprophyticus strain ATCC 15305-08 Corynebacterium efficiensFor strain Peer YS-314-08 Review Only Dickeya dadantii strain Ech586-01 Anaplasma phagocytophilum str. HZ-01 Listeria monocytogenes strain 4b F2365-08 Buchnera aphidicola str. Cc (Cinara cedri)-08 Caldivirga maquilingensis strain IC-167-08 Arthrobacter aurescens strain TC1-30 Methanococcus maripaludis strain C5-08 Streptomyces griseus subsp. griseus strain NBRC 13350-30 Lactobacillus rhamnosus strain GG-30 Leptospira interrogans serovar Lai str. 56601-01 Archaeoglobus profundus strain DSM 5631-30 Stenotrophomonas maltophilia strain R551-3-01 Lawsonia intracellularis strain PHE/MN1-00-08 Erwinia amylovora strain ATCC 49946-01 Paenibacillus sp. JDR-2-01 Leifsonia xyli subsp. xyli strain CTCB07-08 Geobacter metallireducens strain GS-15-01 Salinispora arenicola strain CNS-205-08 Lawsonia intracellularis strain PHE/MN1-00-01 Leptospira biflexa serovar Patoc strain Paris-01 Pectobacterium carotovorum subsp. carotovorum strain PC1-01 Fusobacterium nucleatum subsp. nucleatum str. ATCC 25586-08 epsilon proteobacterium AmH-01 Anaplasma marginale subsp. centrale str. Israel-01 Streptococcus suis strain BM407-08 Escherichia coli 55989-30 Campylobacter jejuni subsp. jejuni strain 81116-08 Citrobacter rodentium strain ICC168-01 Campylobacter fetus subsp. fetus strain 82-40-08 Thermomonospora curvata strain DSM 43183-01 Thermodesulfovibrio yellowstonii DSM 11347-01 Pectobacterium carotovora subsp. atroseptica str. SCRI1043-01 Geobacillus sp. Y412MC61-30 Corynebacterium efficiens strain YS-314-30 Mycobacterium bovis BCG strain Tokyo 172-08 Desulfohalobium retbaense strain DSM 5692-01

Wiley-Blackwell and Society for Applied Microbiology Page 424 of 848

Bordetella parapertussis strain 12822-01 Chlamydia trachomatis strain 434/Bu-08 Photorhabdus asymbiotica Fischer-Le Saux et al. 1999 emend. Akhurst et al. 2004-01 Escherichia fergusonii strain ATCC 35469-01 Delftia acidovorans strain SPH-1-01 Escherichia coli UMN026-30 Clostridium kluyveri strain NBRC 12016-08 Geobacter uraniumreducens Rf4-01 Denitrovibrio acetiphilus strain DSM 12809-01 Neorickettsia sennetsu str. Miyayama-08 Erwinia amylovora strainFor CFBP1430-01 Peer Review Only Pyrococcus sp. OT3-08 Methylobacterium sp. DM4-01 Salmonella enterica subsp. enterica serovar Typhi str. Ty2-01 Yersinia pseudotuberculosis strain IP 31758-01 Prochlorococcus sp. MIT9211-01 Bacillus megaterium strain DSM319-08 Thermoanaerobacter sp. X514-08 Burkholderia sp. PsJN-01 Herpetosiphon aurantiacus DSM 785-01 Leptospira borgpetersenii serovar Hardjo-bovis strain L550-08 Methanococcus maripaludis strain C7-08 Desulfatibacillum alkenivorans strain AK-01-01 Burkholderia vietnamiensis strain G4-01 Methanothermobacter thermautotrophicus str. deltaH-08 Burkholderia sp. CCGE1002-01 Chlorobium limicola strain DSM 245-01 Prevotella ruminicola strain 23-01 Klebsiella variicola strain At-22-01 Mycobacterium vanbaalenii strain PYR-1-08 Thermoanaerobacter italicus strain Ab9-08 Microcystis aeruginosa NIES-843-01 Streptococcus agalactiae str. A909-30 Synechococcus sp. strain JA-2-3B'a(2-13)-01 Candidatus Desulforudis audaxviator strain MP104C-08 Vibrio cholerae strain M66-2-01 Acaryochloris marina MBIC11017-01 Frankia alni strain ACN14a-08 Rhodococcus sp. RHA1-01 Salmonella enterica subsp. enterica serovar Agona str. SL483-30 Salinibacter ruber strain DSM 13855-08 Clostridium acetobutylicum strain ATCC 824-08 Pelodictyon luteolum DSM 273-01 Methanosarcina acetivorans str. C2A-08 Xylella fastidiosa strain M23-01 Acidovorax sp. JS42-01 Ralstonia pickettii strain 12J-01

Wiley-Blackwell and Society for Applied Microbiology Page 425 of 848

Desulfovibrio salexigens strain DSM 2638-01 Thermus thermophilus HB8-01 Sulfurihydrogenibium azorense strain Az-Fu1-01 Campylobacter lari strain RM2100-01 Clostridium sp. OhILAs-01 Halothermothrix orenii strain H 168-01 Clostridium botulinum A strain Hall-08 Mycoplasma mycoides subsp. mycoides SC strain PG1-08 Mycobacterium avium subsp. paratuberculosis strain K-10-08 Bordetella bronchiseptica RB50-01 Cloacamonas acidaminovorans-01For Peer Review Only Citrobacter koseri strain ATCC BAA-895-01 Photorhabdus luminescens subsp. laumondii str. TTO1-01 Desulfotomaculum reducens strain MI-1-01 Borrelia recurrentis strain A1-08 Bacteroides thetaiotaomicron strain VPI-5482-01 Streptomyces scabies 87.22-08 Orientia tsutsugamushi strain Boryong-01 Bacillus tusciae strain DSM 2912-30 Thermotoga sp. TMO-30 Ehrlichia ruminantium strain Gardel-01 Halorhabdus utahensis strain DSM 12940-30 Methanococcus aeolicus strain Nankai-3-08 Bacillus thuringiensis serovar konkukian strain 97-27-30 Syntrophus aciditrophicus strain SB-01 Pseudomonas sp. LB400-01 Streptomyces griseus subsp. griseus strain NBRC 13350-08 Burkholderia glumae strain BGR1-01 Chloroflexus aggregans strain DSM 9485-01 Methylobacterium extorquens strain PA1-01 Sodalis glossinidius Dale and Maudlin 1999-01 Carboxydothermus hydrogenoformans str. Z-2901-30 Methanobrevibacter ruminantium strain M1-08 Thermotoga sp. TMO-08 Clostridium cellulolyticum strain H10-08 marine firmicute HTE831-08 Geobacter sulfurreducens strain PCA-01 Acidobacterium capsulatum strain ATCC 51196-01 Salmonella typhimurium LT2-08 Escherichia coli strain ED1a-01 Fervidobacterium nodosum strain Rt17-B1-08 Methanothrix thermophila PT-30 Xanthomonas campestris pv. campestris strain B100-01 Enterobacter sakazakii ATCC BAA-894-01 Shigella dysenteriae strain Sd197-08 Moorella thermoacetica strain ATCC 39073-30 Methanococcus maripaludis strain C6-08

Wiley-Blackwell and Society for Applied Microbiology Page 426 of 848

Thermotoga sp. RQ2-08 Thermobifida fusca strain YX-01 Sodalis glossinidius strain 'morsitans'-01 Anaerococcus prevotii strain DSM 20548-08 Methanosphaerula palustris strain E1-9c-08 Deinococcus deserti strain VCD115-01 Mycobacterium sp. MCS-08 Mycobacterium avium str. 104-08 methanogenic archaeon strain SANAE-30 Bacillus cereus strain AH187-30 Gordonia bronchialisFor strain DSM Peer 43247-01 Review Only Lactobacillus gasseri strain ATCC 33323-08 Streptococcus dysgalactiae subsp. equisimilis strain GGS_124-08 Thermotoga neapolitana NS-E-08 Lactococcus lactis subsp. cremoris strain MG1363-30 Mycobacterium tuberculosis strain KZN 1435-30 Burkholderia pseudomallei strain MSHR346-01 Clostridium tetani str. E88-08 Deinococcus radiodurans str. R1-01 Mycobacterium sp. JLS-08 Mycobacterium tuberculosis CSU#93-30 Bacillus halodurans strain C-125-30 bacterium EX-H1-01 Streptomyces coelicolor A3(2)-08 Bacillus pumilus strain SAFR-032-08 Borrelia turicatae strain 91E135-30 Gluconacetobacter diazotrophicus strain PAl 5-01 Methanohalophilus mahii strain DSM 5219-30 Xanthomonas campestris pv. campestris str. ATCC 33913-01 Mycobacterium bovis BCG strain Tokyo 172-30 Nostoc sp. PCC 7937-01 Helicobacter mustelae strain 12198-30 Bacillus cytotoxis NVH 391-98-01 Prochlorococcus sp. MIT9303-01 Anaplasma marginale strain St. Maries-01 Clostridium botulinum B1 strain Okra-01 Rhodococcus opacus strain B4-01 Orientia tsutsugamushi strain Ikeda-01 Desulfovibrio desulfuricans subsp. desulfuricans strain G20-01 Clostridium kluyveri strain DSM 555-08 Corynebacterium diphtheriae NCTC13129-08 Synechococcus sp. PCC 7424-01 Anaerocellum thermophilum strain DSM 6725-08 Catenulispora acidiphila strain DSM 44928-08 Caldicellulosiruptor saccharolyticus strain DSM 8903-08 Streptobacillus moniliformis strain DSM 12112-08 Meiothermus ruber strain DSM 1279-01

Wiley-Blackwell and Society for Applied Microbiology Page 427 of 848

Xanthomonas axonopodis pv. citri str. 306-01 Geobacter sp. FRC-32-01 Acholeplasma laidlawii strain PG-8A-08 Anaplasma phagocytophilum str. HZ-08 Campylobacter jejuni subsp. jejuni strain 81-176-08 Exiguobacterium strain 255-15-01 Symbiobacterium thermophilum strain IAM 14863-01 Moorella thermoacetica strain ATCC 39073-01 Sulfurihydrogenibium sp. YO3AOP1-01 Fervidobacterium nodosum strain Rt17-B1-01 bacterium Ellin345-01For Peer Review Only Rickettsia rickettsii strain Iowa-01 Francisella tularensis subsp. holarctica strain OSU18-08 not Oenococcus oeni MCW-08 Streptococcus pneumoniae TIGR4-08 sulfate-reducing bacterium Hxd3-01 Klebsiella pneumoniae strain NTUH-K2044-01 Geobacillus kaustophilus HTA426-01 Ralstonia solanacearum strain MolK2-01 Haliangium ochraceum strain DSM 14365-01 Campylobacter jejuni subsp. doylei strain 269.97-08 Thermus thermophilus strain HB27-01 Geobacillus sp. Y412MC61-01 Heliobacterium modesticaldum strain Ice1-01 Brevibacillus brevis strain NBRC 100599-01 Actinobacillus pleuropneumoniae strain L20-01 Campylobacter curvus strain 525.92-08 Nostoc sp. strain PCC 7120-01 Cryptobacterium curtum strain DSM 15641-01 Thermosipho africanus strain TCF52B-08 Rickettsia conorii strain Malish 7-01 Pelobacter propionicus strain DSM 2379-01 Saccharomonospora viridis strain DSM 43017-01 Bacillus halodurans strain C-125-01 Methylobacterium sp. CM4-01 Clostridium botulinum A strain ATCC 3502-30 Micrococcus luteus ATCC 9341-01 Pyrococcus abyssi strain GE5-08 Salmonella enterica subsp. enterica serovar Schwarzengrund strain CVM19633-08 Escherichia coli UMN026-01 Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2-30 Thermomicrobium roseum DSM 5159-01 Campylobacter fetus subsp. fetus strain 82-40-01 Campylobacter hominis strain ATCC BAA-381-01 Klebsiella pneumoniae strain 342-01 Xanthomonas campestris pv. campestris strain 8004-01 Listeria innocua strain Clip11262-08

Wiley-Blackwell and Society for Applied Microbiology Page 428 of 848

Pediococcus pentosaceus strain ATCC 25745-30 Streptococcus sanguinis strain SK36-08 Listeria seeligeri serovar 1/2b strain SLCC3954-30 Clostridium botulinum B1 strain Okra-08 Nanoarchaeum equitans str. Kin4-M-01 Leifsonia xyli subsp. xyli strain CTCB07-01 Streptococcus equi subsp. zooepidemicus strain MGCS10565-08 Lactobacillus plantarum strain JDM1-08 Xanthomonas euvesicatoria str. 85-10-01 Ehrlichia ruminantium strain Welgevonden-08 Bifidobacterium adolescentisFor strain Peer ATCC 15703-30 Review Only Sanguibacter keddieii strain DSM 10542-01 Salmonella enterica subsp. enterica serovar Gallinarum strain 287/91-01 Escherichia coli O127:H6 strain E2348/69-30 Coprothermobacter proteolyticus DSM 5265-08 Campylobacter curvus strain 525.92-01 Burkholderia cepacia str. J2315-01 Escherichia coli strain S88-08 Staphylothermus marinus strain F1-08 Aquifex aeolicus str. VF5-01 Nocardia farcinica strain IFM 10152-01 Xanthomonas oryzae pv. oryzae strain KACC10331-01 Chlorobium phaeobacteroides strain DSM 266-01 Nostoc sp. PCC73102-01 Salmonella enterica subsp. enterica serovar Heidelberg str. SL476-01 Geobacter sp. M21-01 Elusimicrobium minutum strain Pei191-01 Bifidobacterium longum str. DJO10A-08 Pseudomonas sp. AM1-01 Ralstonia solanacearum strain IPO1609-01 Mimi-01 Archaeoglobus fulgidus strain VC-16-08 Helicobacter acinonychis strain Sheeba-08 uncultured Termite group 1 bacterium phylotype Rs-D17-01 Exiguobacterium sp. AT1b-01 Alkaliphilus metalliredigens strain QYMF-01 Thermobaculum terrenum strain ATCC BAA-798-01 Escherichia coli O103:H2 strain 12009-30 Clostridium botulinum Ba4 strain 657-30 Thermosipho melanesiensis strain BI429-08 Kribbella flavida strain DSM 17836-01 Salmonella enterica subsp. enterica serovar Dublin strain CT_02021853-01 Nocardioides sp. JS614-01 Verrucomicrobiae bacterium V4-01 Hydrogenobacter thermophilus strain TK-6-08 Corynebacterium glutamicum strain R-08 Streptosporangium roseum strain DSM 43021-01

Wiley-Blackwell and Society for Applied Microbiology Page 429 of 848

marine firmicute HTE831-01 Frankia sp. CcI3-01 Streptococcus mutans str. UA159-08 Macrococcus caseolyticus strain JCSC5402-01 Escherichia coli O55:H7 strain CB9615-01 Veillonella parvula strain DSM 2008-01 Clostridium botulinum A3 strain Loch Maree-30 Yersinia pestis strain CO92-01 Yersinia pestis bv. Microtus str. 91001-08 Thermocrinis albus strain DSM 14484-08 Methanococcus vannieliiFor strain SB-08Peer Review Only Desulfovibrio magneticus strain RS-1-01 Natranaerobius thermophilus strain JW/NM-WN-LF-01 Mycobacterium abscessus strain ATCC 19977-01 Corynebacterium kroppenstedtii strain DSM 44385-08 Fibrobacter succinogenes subsp. succinogenes S85-01 Thermocrinis albus strain DSM 14484-01 Synechococcus sp. RF-2-01 Geobacter bemidjiensis strain Bem-01 Xanthomonas oryzae pv. oryzae strain MAFF 311018-01 Leptospira borgpetersenii serovar Hardjo-bovis strain JB197-01 Escherichia coli O157:H7 EDL933-30 Kytococcus sedentarius strain DSM 20547-01 Pelotomaculum thermopropionicum strain SI-01 Brachyspira hyodysenteriae strain WA1-01 DSM 13-30 Mycobacterium gilvum strain PYR-GCK-08 Acinetobacter baumannii strain AB307-0294-01 Helicobacter mustelae strain 12198-01 Clostridium difficile strain CD196-01 Yersinia pestis strain Angola-01 Atopobium parvulum strain DSM 20469-01 Escherichia coli strain SE11-08 Methanococcoides burtonii str. DSM 6242-01 Haloarcula marismortui strain ATCC 43049-08 Clostridium botulinum A2 strain Kyoto-08 endosymbiont of Acanthamoeba sp. UWE25-01 Streptococcus thermophilus strain LMD-9-30 Clostridium acetobutylicum strain ATCC 824-01 Finegoldia magna strain ATCC 29328-08 Leptotrichia buccalis strain C-1013-b-01 Campylobacter concisus strain 13826-01 Escherichia coli O111:H- strain 11128-01 Yersinia pestis strain Angola-08 Escherichia coli O103:H2 strain 12009-08 Salmonella enterica subsp. enterica serovar Choleraesuis strain SC-B67-08 Yersinia pestis strain Pestoides F-01

Wiley-Blackwell and Society for Applied Microbiology Page 430 of 848

Kineococcus-like str. SRS30216-01 Actinosynnema mirum strain DSM 43827-08 Salinibacter ruber Anton et al. 2002-01 Sulfolobus solfataricus strain P2-08 Ureaplasma urealyticum ATCC 700970-01 Xylanimonas cellulosilytica strain DSM 15894-30 Arthrobacter aurescens strain TC1-01 marine firmicute HTE831-30 Micrococcus luteus strain NCTC 2665-01 Corynebacterium kroppenstedtii strain DSM 44385-01 Lactococcus lactis subsp.For lactis strainPeer Il1403-08 Review Only Fusobacterium nucleatum subsp. nucleatum str. ATCC 25586-01 Thermoanaerobacter pseudethanolicus strain ATCC 33223-01 Xanthomonas oryzae pv. oryzae strain PXO99A-01 Leptotrichia buccalis strain C-1013-b-30 Lactobacillus crispatus strain ST1-01 Natranaerobius thermophilus strain JW/NM-WN-LF-08 bacterium Ellin6076-01 Clostridium botulinum B strain Eklund 17B-30 Sebaldella termitidis strain ATCC 33386-30 Escherichia coli 55989-08 Salmonella enterica subsp. enterica serovar Paratyphi A strain AKU_12601-01 Geobacillus sp. Y412MC61-08 Burkholderia cenocepacia AU 1054-01 Tropheryma whipplei str. TW08/27-01 Salmonella typhi CT18-08 Borrelia hermsii strain DAH-01 Streptococcus suis str. P1/7-08 Corynebacterium efficiens strain YS-314-01 Escherichia coli strain CFT073-01 Mycobacterium gilvum strain PYR-GCK-01 Escherichia coli strain IAI1-30 Burkholderia thailandensis strain E264-01 Thermanaerovibrio acidaminovorans strain DSM 6589-01 Ehrlichia ruminantium strain Welgevonden-01 Chloroflexus sp. Y-400-fl-01 Streptococcus thermophilus strain LMG 18311-08 Staphylococcus epidermidis ATCC 12228-08 Salinospora sp. CNB440-01 Streptococcus uberis str. 0140J-30 Yersinia pseudotuberculosis strain YPIII-01 Beutenbergia cavernae strain DSM 12333-01 Helicobacter pylori strain 26695-30 Bacillus sp. KSM-K16-30 Burkholderia cenocepacia strain MC0-3-01 Borrelia turicatae strain 91E135-08 Streptococcus gordonii str. Challis substr. V288-08

Wiley-Blackwell and Society for Applied Microbiology Page 431 of 848

Dictyoglomus thermophilum H-6-12-01 Rickettsia rickettsii strain 'Sheila Smith'-01 Methanocorpusculum labreanum strain Z-08 Shigella flexneri serotype 2a str. 2457T-01 Campylobacter jejuni subsp. jejuni strain NCTC 11168-08 Burkholderia ambifaria strain MC40-6-01 Burkholderia mallei strain NCTC 10247-01 Corynebacterium nigricans CN-1-01 methanogenic archaeon 6A8-08 Aeropyrum pernix strain K1-08 MethanothermobacterFor thermautotrophicus Peer str. deltaH-01Review Only Eubacterium rectale strain ATCC 33656-01 Escherichia coli strain ATCC 8739-30 Clostridium novyi-NT-01 Halomicrobium mukohataei strain DSM 12286-08 Salinibacter ruber strain DSM 13855-01 Escherichia coli O157:H7 str. EC4115-01 Listeria seeligeri serovar 1/2b strain SLCC3954-08 Staphylococcus carnosus subsp. carnosusstrain TM300-01 Escherichia coli strain IAI1-08 Salmonella enterica subsp. enterica serovar Newport strain SL254-08 Bacillus amyloliquefaciens strain FZB42-01 Desulfovibrio vulgaris vulgaris (strain Hildenborough)-01 Borrelia burgdorferi strain ZS7-08 Salmonella enterica subsp. enterica serovar Agona str. SL483-01 Lactococcus lactis subsp. cremoris strain SK11-30 Campylobacter jejuni subsp. doylei strain 269.97-01 Listeria seeligeri serovar 1/2b strain SLCC3954-01 Leptospira borgpetersenii serovar Hardjo-bovis strain L550-01 Clostridium perfringens strain SM101-08 Frankia alni strain ACN14a-01 Methanosphaerula palustris strain E1-9c-01 Clostridium phytofermentans strain ISDg-30 Anaeromyxobacter sp. K-01 Lactobacillus rhamnosus strain GG-08 Anaerococcus prevotii strain DSM 20548-01 Escherichia coli O26:H11 strain 11368-08 Bacillus cereus strain G9842-08 Clostridium thermocellum strain ATCC 27405-01 Roseiflexus sp. strain RS-1-01 Methanococcus maripaludis strain S2-08 Syntrophobacter fumaroxidans strain MPOB-01 Salmonella enterica subsp. enterica serovar Enteritidis strain P125109-01 Chlamydia trachomatis MoPn strain Nigg-01 Dehalococcoides ethenogenes strain 195-01 Sphaerobacter thermophilus strain DSM 20745-01 Mycoplasma capricolum subsp. capricolum strain ATCC 27343-01

Wiley-Blackwell and Society for Applied Microbiology Page 432 of 848

Streptococcus gordonii str. Challis substr. V288-01 Thermotoga sp. TMO-01 Shigella sonnei strain Ss046-30 Alicyclobacillus acidocaldarius subsp. acidocaldarius strain DSM 446-01 Burkholderia pseudomallei strain 668-01 Burkholderia multivorans strain ATCC 17616-01 Thermosipho africanus strain TCF52B-01 Bifidobacterium lactis AD011-08 Bifidobacterium animalis subsp. lactis strain DSM 10140-08 Prochlorococcus sp. MIT9313-01 Bifidobacterium dentiumFor strain Bd1-08Peer Review Only Bacillus megaterium strain DSM319-01 Streptococcus pyogenes strain MGAS2096-08 Rhodococcus erythropolis strain PR4-01 Thermoanaerobacter sp. X514-01 Eubacterium eligens strain ATCC 27750-01 Gardnerella vaginalis strain 409-05-01 Candidatus Desulforudis audaxviator strain MP104C-01 Clostridium difficile strain 630-01 Corynebacterium glutamicum ATCC 13032-30 Campylobacter jejuni subsp. jejuni strain 81116-01 Salmonella enterica subsp. enterica serovar Schwarzengrund strain CVM19633-01 Anaeromyxobacter sp. Fw109-5-01 Mycobacterium sp. KMS-08 Frankia sp. EAN1pec-01 Jonesia denitrificans strain DSM 20603-01 Thermoanaerobacter tengcongensis strain MB4-01 Bacillus cereus strain AH187-08 Conexibacter woesei strain DSM 14684-01 Ignicoccus sp. Kin4-I-01 Chlamydophila pneumoniae J138-01 Thermoanaerobacter italicus strain Ab9-01 Streptococcus thermophilus strain LMD-9-01 Mycobacterium smegmatis strain MC2 155-01 Streptococcus pneumoniae strain Taiwan19F-14-08 Clostridium botulinum E3 strain Alaska E43-08 Campylobacter concisus strain 13826-08 Clostridium cellulolyticum strain H10-01 Burkholderia pseudomallei strain 1710b-01 Syntrophomonas wolfei subsp. wolfei strain Goettingen-01 Escherichia coli strain BW2952-01 Picrophilus torridus strain DSM 9790-01 Streptococcus uberis str. 0140J-01 Yersinia pseudotuberculosis strain IP 32953-01 Myxococcus xanthus strain DK 1622-01 Dictyoglomus turgidum strain DSM 6724-01 Mycobacterium sp. MCS-01

Wiley-Blackwell and Society for Applied Microbiology Page 433 of 848

Staphylococcus aureus subsp. aureus Mu50-01 Burkholderia cenocepacia HI2424-01 Dehalococcoides sp. BAV1-01 Burkholderia mallei strain 10229-01 Bacillus cereus ATCC 14579-08 Thermanaerovibrio acidaminovorans strain DSM 6589-30 Escherichia coli strain ATCC 8739-08 Anaeromyxobacter dehalogenans strain 2CP-1-01 Salmonella paratyphi C strain RKS4594-30 Bacillus cereus strain AH820-08 Caldicellulosiruptor Forsaccharolyticus Peer strain DSM 8903-01Review Only Burkholderia cepacia AMMD-01 Streptomyces griseus subsp. griseus strain NBRC 13350-01 Xylanimonas cellulosilytica strain DSM 15894-01 Ferroglobus placidus strain DSM 10642-01 Onion yellows phytoplasma str. 'onion yellows'-01 Thermotoga maritima strain MSB8-08 Streptobacillus moniliformis strain DSM 12112-01 Ammonifex degensii strain KC4-01 Corynebacterium diphtheriae NCTC13129-01 Bifidobacterium adolescentis strain ATCC 15703-01 Methanohalophilus mahii strain DSM 5219-01 Anaeromyxobacter dehalogenans strain 2CP-C-01 Streptococcus pneumoniae strain ATCC 700669-08 Lactobacillus salivarius subsp. salivarius UCC118-08 Escherichia coli O103:H2 strain 12009-01 Methanothrix thermophila PT-01 Bacillus tusciae strain DSM 2912-01 Clostridium difficile strain R20291-01 Candidatus Hodgkinia cicadicola strain Dsem-01 Burkholderia pseudomallei strain 1106a-01 Desulfotomaculum acetoxidans strain DSM 771-01 Clostridium botulinum E3 strain Alaska E43-01 Streptococcus sanguinis strain SK36-01 Borrelia turicatae strain 91E135-01 Sebaldella termitidis strain ATCC 33386-01 Burkholderia pseudomallei strain K96243-01 Catenulispora acidiphila strain DSM 44928-01 Arthrobacter chlorophenolicus strain A6-01 Helicobacter pylori strain J99-01 Stackebrandtia nassauensis strain DSM 44728-01 Chlamydophila felis strain Fe/C-56-01 Methanococcus jannaschii DSM 2661-08 Shigella boydii strain CDC 3083-94-08 Anaerocellum thermophilum strain DSM 6725-01 Clostridium botulinum B strain Eklund 17B-01 Methanococcus aeolicus strain Nankai-3-01

Wiley-Blackwell and Society for Applied Microbiology Page 434 of 848

Streptococcus suis strain BM407-01 Lysinibacillus sphaericus strain C3-41-01 Thermotoga sp. RKU-10-08 Bifidobacterium longum subsp. infantis strain ATCC 15697-08 Clostridium phytofermentans strain ISDg-01 Lactococcus lactis subsp. lactis strain KF147-08 Listeria monocytogenes strain 08-5578-08 Salmonella typhi CT18-30 Streptomyces scabies 87.22-01 Lactococcus lactis subsp. cremoris strain MG1363-01 Staphylococcus aureusFor subsp. aureus Peer strain Newman-08 Review Only methanogenic archaeon strain SANAE-01 Staphylococcus aureus subsp. aureus COL-08 Treponema denticola str. ATCC 35405-01 Klebsiella pneumoniae (Schroeter 1886) Trevisan 1887-01 Thermosipho melanesiensis strain BI429-01 Escherichia coli strain SMS-3-5-08 Roseiflexus castenholzii strain DSM 13941-01 Methanosarcina mazei strain Go1-01 Streptococcus thermophilus strain CNRZ1066-01 Borrelia afzelii strain PKo-08 Campylobacter jejuni subsp. jejuni strain NCTC 11168-01 Lactobacillus salivarius subsp. salivarius UCC118-01 Methanocaldococcus fervens strain AG86-01 Staphylococcus aureus subsp. aureus Mu50-08 Haloquadratum walsbyi strain DSM 16790-01 Lactobacillus reuteri strain JCM 1112-08 Renibacterium salmoninarum strain ATCC 33209-01 Clostridium botulinum A3 strain Loch Maree-08 Yersinia pestis bv. Microtus str. 91001-01 Thermotoga sp. RKU-1-01 Mycobacterium sp. JLS-01 Mycobacterium tuberculosis strain KZN 1435-01 Desulfovibrio vulgaris strain 'Miyazaki F'-01 Burkholderia mallei strain SAVP1-01 Finegoldia magna strain ATCC 29328-01 Methanoculleus marisnigri strain JR1-30 Lactococcus lactis subsp. cremoris strain SK11-08 Bacillus medusa-01 Streptococcus gallolyticus strain UCN34-08 Clostridium beijerinckii strain NCIMB 8052-08 Bacillus thuringiensis strain Al Hakam-08 Thermotogales bacterium TBF 19.5.1-01 Streptococcus equi subsp. equi strain 4047-08 Bacillus sp. KSM-K16-01 Mycobacterium tuberculosis CSU#93-08 Escherichia coli strain HS-30

Wiley-Blackwell and Society for Applied Microbiology Page 435 of 848

Hydrogenobacter thermophilus strain TK-6-01 Methanoculleus marisnigri strain JR1-08 Salmonella paratyphi C strain RKS4594-01 Enterococcus faecalis str. V583-01 Staphylococcus epidermis RP62A-08 Shigella boydii strain Sb227-08 Hydrogenobaculum sp. Y04AAS1-30 Petrotoga mobilis strain SJ95-01 Streptomyces avermitilis str. MA-4680-01 Acholeplasma laidlawii strain PG-8A-01 Mycobacterium marinumFor strain M-01Peer Review Only Mycobacterium leprae strain TN-01 Mycoplasma pulmonis strain UAB CTIP-01 Ehrlichia canis strain Jake-08 Pseudobacterium sepedonicum-01 Salmonella enterica subsp. enterica serovar Schwarzengrund strain CVM19633-30 Salmonella enterica subsp. enterica serovar Dublin strain CT_02021853-08 Dehalococcoides sp. VS-01 Mycobacterium tuberculosis strain H37Rv-08 Streptomyces coelicolor A3(2)-01 methanogenic archaeon 6A8-01 Clostridium beijerinckii strain NCIMB 8052-01 Clostridium perfringens str. 13-01 Listeria monocytogenes strain HCC23-01 Helicobacter acinonychis strain Sheeba-01 Shigella dysenteriae strain Sd197-01 Escherichia coli strain E24377A-01 Pseudomonas resinovorans Delaporte et al. 1961-01 Lactobacillus plantarum strain WCFS1-08 Staphylococcus epidermis RP62A-01 Salmonella enterica subsp. enterica serovar Paratyphi B strain SPB7-01 Campylobacter jejuni strain RM1221-01 Hyperthermus butylicus strain DSM 5456-01 Dehalococcoides sp. GT-01 Clostridium botulinum A strain ATCC 19397-01 Bacillus cereus strain B4264-08 Clostridium perfringens strain ATCC 13124-01 Proteinoruptor kamchatkensis 1221n-01 Staphylococcus aureus strain RF122-08 Listeria monocytogenes strain EGD-e-08 Mycobacterium avium subsp. paratuberculosis strain K-10-01 Saccharopolyspora erythraea strain NRRL 2338-01 Methanosphaerula palustris strain E1-9c-30 Escherichia coli strain SMS-3-5-01 Mycobacterium avium str. 104-01 Clostridium perfringens strain SM101-01 Thermoplasma volcanium strain GSS1-08

Wiley-Blackwell and Society for Applied Microbiology Page 436 of 848

Methanococcus jannaschii DSM 2661-01 Desulfitobacterium hafniense DSM 10664-01 Listeria welshimeri serovar 6b strain SLCC5334-01 Clavibacter michiganensis subsp. michiganensis strain NCPPB 382-01 Gardnerella vaginalis strain 409-05-08 Campylobacter jejuni subsp. jejuni strain 81-176-01 Escherichia coli strain SE11-01 Salinispora arenicola strain CNS-205-01 Salmonella enterica subsp. enterica serovar Newport strain SL254-01 Staphylococcus aureus subsp. aureus strain ED98-08 MethanocaldococcusFor vulcanius strainPeer M7-08 Review Only Rothia mucilaginosa strain DY-18-01 Brachybacterium faecium strain DSM 4810-01 Bifidobacterium animalis subsp. lactis strain Bl-04-01 Streptococcus mitis strain B6-01 Sorangium cellulosum strain 'So ce 56'-01 Mycobacterium vanbaalenii strain PYR-1-01 Escherichia coli strain APEC O1-08 Coxiella burnetii strain RSA 331-30 Streptococcus pyogenes str. SSI-1-08 Methanospirillum hungatei strain JF-1-01 Arthrobacter sp. FB24-01 Thermotoga maritima strain MSB8-01 Clostridium botulinum F strain Langeland-08 Bacillus weihenstephanensis strain KBAB4-08 Mycobacterium ulcerans strain Agy99-01 Bacillus cereus strain 03BB102-01 Halobacterium salinarum strain R1-08 Actinosynnema mirum strain DSM 43827-01 Methanobrevibacter smithii strain ATCC 35061-01 Yersinia pestis strain KIM 10-08 Bacillus weihenstephanensis strain KBAB4-01 Lactobacillus johnsonii NCC 533-01 Methanococcus maripaludis strain C5-30 Corynebacterium glutamicum strain R-01 Bacillus anthracis strain CDC 684-01 Yersinia pestis strain Antiqua-01 Methanocorpusculum labreanum strain Z-01 Escherichia coli O26:H11 strain 11368-01 Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578-01 Staphylococcus epidermidis ATCC 12228-01 Archaeoglobus profundus strain DSM 5631-01 Clostridium botulinum Ba4 strain 657-08 Bacillus pumilus strain SAFR-032-01 Lactococcus lactis subsp. lactis strain KF147-01 Bacillus megaterium strain QM B1551-01 Aminobacterium colombiense strain DSM 12261-01

Wiley-Blackwell and Society for Applied Microbiology Page 437 of 848

uncultured methanogenic archaeon Rice Cluster I-01 Thermoanaerobacter tengcongensis strain MB4-30 Desulfovibrio vulgaris subsp. vulgaris DP4-01 Veillonella parvula strain DSM 2008-08 Bacillus cereus strain E33L-30 Haloterrigena turkmenica strain DSM 5511-30 Streptococcus suis strain 98HAH33-01 Archaeoglobus profundus strain DSM 5631-08 Neorickettsia risticii strain Illinois-08 Anaplasma marginale strain Florida-01 Escherichia coli O157:H7For strain TW14359-01Peer Review Only Eggerthella lenta strain DSM 2243-01 Clostridium tetani str. E88-01 Geobacillus sp. Y412MC10-01 Desulfitobacterium sp. Y51-01 Chlamydophila caviae str. GPIC-01 Mycoplasma mobile strain 163K-01 Thermococcus onnurineus strain NA1-08 Bacillus weihenstephanensis strain KBAB4-30 Clostridium botulinum A3 strain Loch Maree-01 Clostridiales genomosp. BVAB3 str. UPII9-5-01 Aminobacterium colombiense strain DSM 12261-08 Staphylococcus lugdunensis strain HKU09-01-01 Mycobacterium tuberculosis strain H37Rv-30 Methanosarcina barkeri strain Fusaro-01 Chloroflexus aurantiacus strain J-10-fl-01 Sanguibacter keddieii strain DSM 10542-30 Mycoplasma arthritidis strain 158L3-1-01 Escherichia coli strain 536-30 Halorhabdus utahensis strain DSM 12940-01 Mycobacterium sp. KMS-01 Methanobrevibacter ruminantium strain M1-01 Escherichia coli strain IAI1-01 Enterococcus faecalis str. V583-30 Campylobacter concisus strain 13826-30 Staphylococcus carnosus subsp. carnosusstrain TM300-08 Phytoplasma solani australensis-08 not Oenococcus oeni MCW-01 Bacillus subtilis subsp. subtilis str. BGSC 1A700-01 Staphylococcus saprophyticus subsp. saprophyticus strain ATCC 15305-01 Dictyoglomus thermophilum H-6-12-08 Bifidobacterium adolescentis strain ATCC 15703-08 Escherichia coli 55989-01 Pyrococcus furiosus strain DSM 3638-01 Methanothermobacter thermautotrophicus str. deltaH-30 Halorubrum lacusprofundi strain ATCC 49239-01 Corynebacterium glutamicum ATCC 13032-08

Wiley-Blackwell and Society for Applied Microbiology Page 438 of 848

Chlamydophila abortus str. S26/3-01 Blattabacterium sp. (Periplaneta americana) strain BPLAN-30 Listeria monocytogenes strain 4b F2365-01 Slackia heliotrinireducens strain DSM 20476-01 Escherichia coli strain APEC O1-01 Salmonella enterica subsp. enterica serovar Paratypi A str. ATCC 9150-30 Leuconostoc mesenteroides subsp. mesenteroides strain ATCC 8293-01 Helicobacter pylori strain B38-01 Lactobacillus delbrueckii subsp. bulgaricus strain ATCC BAA-365-08 Methanosarcina acetivorans str. C2A-01 Clostridium botulinumFor Ba4 strain Peer 657-01 Review Only Listeria monocytogenes strain 08-5578-30 Rickettsia peacockii strain Rustic-08 Geobacillus thermodenitrificans strain NG80-2-30 Methanococcus maripaludis strain C5-01 Lactobacillus sakei subsp. sakei strain 23K-01 Streptococcus pneumoniae strain Taiwan19F-14-01 Halobacterium sp. NRC-1-08 Helicobacter pylori strain Shi470-01 Corynebacterium urealyticum strain DSM 7109-08 Bacillus cereus strain AH187-01 Methanococcus vannielii strain SB-01 Borrelia burgdorferi strain ZS7-01 Thermotoga neapolitana NS-E-01 Burkholderia mallei str. ATCC 23344-01 Bacillus cereus strain G9842-30 Pediococcus pentosaceus strain ATCC 25745-01 Staphylococcus aureus subsp. aureus str. MW2-01 Chlamydia trachomatis strain B/Jali20/OT-01 Halorubrum lacusprofundi strain ATCC 49239-08 Enterococcus faecalis str. V583-08 Hyperthermus butylicus strain DSM 5456-08 Lactobacillus fermentum strain IFO 3956-01 Pleuropneumonia agalactiae-01 Phytoplasma solani australensis-01 Methanopyrus kandleri str. AV19-08 Halorhabdus utahensis strain DSM 12940-08 Bacillus thuringiensis strain Al Hakam-01 Lactococcus lactis subsp. lactis strain Il1403-01 Yersinia pestis strain Nepal516-01 Staphylococcus aureus subsp. aureus COL-01 Clostridium kluyveri strain DSM 555-01 Mycoplasma mycoides subsp. mycoides SC strain PG1-01 Shigella boydii strain CDC 3083-94-01 Bacillus cereus strain AH820-01 Methanocaldococcus vulcanius strain M7-01 Lactobacillus brevis strain ATCC 367-01

Wiley-Blackwell and Society for Applied Microbiology Page 439 of 848

Methanococcus maripaludis strain C7-01 Escherichia coli str. B substr. REL606-01 Borrelia afzelii strain PKo-01 Borrelia recurrentis strain A1-01 Bacillus cereus strain B4264-01 Sulfolobus islandicus strain M.16.27-08 Listeria monocytogenes strain EGD-e-01 Sulfolobus islandicus strain Y.G.57.14-08 Streptococcus agalactiae str. 2603V/R-01 Salmonella typhimurium LT2-01 Corynebacterium jeikeiumFor strain Peer K411-01 Review Only Sulfolobus islandicus strain L.D.8.5-08 Methanopyrus kandleri str. AV19-01 Mycobacterium tuberculosis CSU#93-01 bacterium CBDB1-01 Bifidobacterium longum subsp. infantis strain ATCC 15697-01 Micrococcus luteus ATCC 9341-30 Proteinoruptor kamchatkensis 1221n-30 Thermotoga sp. RQ2-01 Shigella boydii strain Sb227-01 Mycobacterium bovis subsp. bovis str. AF2122/97-08 Methanobrevibacter smithii strain ATCC 35061-08 Bacillus cereus strain G9842-01 Escherichia coli strain BL21(DE3)-01 Lactobacillus acidophilus strain NCFM-01 Shigella flexneri 5 strain 8401-08 Streptococcus pyogenes str. MGAS315-01 Bacillus cereus ATCC 14579-01 Lactococcus lactis subsp. cremoris strain SK11-01 Dehalococcoides sp. VS-08 Haloarcula marismortui strain ATCC 43049-30 Bifidobacterium longum str. NCC2705-01 Escherichia coli O157:H7 EDL933-01 Streptococcus agalactiae str. NEM316-01 Escherichia coli strain S88-01 Staphylococcus haemolyticus strain JCSC1435-01 Listeria innocua strain Clip11262-01 Thermococcus gammatolerans strain EJ3-08 Yersinia pestis strain Z176003-01 Chlamydia trachomatis strain B/TZ1A828/OT-01 Borrelia sp. PBi-01 korarchaeote OPF1-KOR-01 Brucella melitensis str. ATCC 23456-01 Clostridium botulinum A2 strain Kyoto-01 Escherichia coli strain ATCC 8739-01 Streptococcus mutans strain NN2025-01 Treponema pallidum subsp. pallidum str. Nichols-01

Wiley-Blackwell and Society for Applied Microbiology Page 440 of 848

Shigella flexneri 5 strain 8401-30 Streptococcus pneumoniae strain P1031-01 Clostridium botulinum F strain Langeland-01 Escherichia coli strain E24377A-08 Escherichia coli IAI39-01 Thermoplasma acidophilum strain DSM 1728-01 Bacillus cereus strain 03BB102-08 Staphylococcus aureus subsp. aureus USA300_FPR3757-01 Bacillus anthracis strain CDC 684-08 DSM 13-01 Streptococcus pneumoniaeFor strain Peer 70585-01 Review Only Streptococcus pneumoniae strain CGSP14-01 Bacillus cereus strain Q1-01 Clostridium botulinum A strain Hall-01 Yersinia pestis bv. Microtus str. 91001-30 Salmonella enterica subsp. enterica serovar Choleraesuis strain SC-B67-01 Staphylococcus aureus subsp. aureus strain ED98-01 Leptotrichia buccalis strain C-1013-b-08 Methanosphaera stadtmanae strain DSM 3091-30 Mycobacterium bovis subsp. bovis str. AF2122/97-30 Bifidobacterium animalis subsp. lactis strain DSM 10140-01 Bacillus cereus strain E33L-01 Escherichia coli strain 536-01 Thermotogales bacterium TBF 19.5.1-08 Bacillus cereus strain Q1-08 Methanobrevibacter smithii strain ATCC 35061-30 DSM 13-08 Aeropyrum pernix strain K1-01 Saccharopolyspora erythraea strain NRRL 2338-30 Mycobacterium bovis BCG strain Tokyo 172-01 Lactobacillus plantarum strain WCFS1-30 Escherichia coli O127:H6 strain E2348/69-01 Pyrococcus sp. OT3-01 Bacillus cereus strain ATCC 10987-08 Staphylococcus aureus subsp. aureus strain MRSA252-01 Leuconostoc citreum strain KM20-01 Salmonella enterica subsp. enterica serovar Paratypi A str. ATCC 9150-08 Bacillus anthracis strain 'Ames Ancestor'-08 Halomicrobium mukohataei strain DSM 12286-01 Thermococcus kodakarensis strain KOD1-01 Listeria welshimeri serovar 6b strain SLCC5334-08 Clostridium botulinum A strain ATCC 3502-01 Streptococcus pneumoniae strain ATCC 700669-01 Bifidobacterium dentium strain Bd1-01 Escherichia coli strain UTI89-01 Archaeoglobus fulgidus strain VC-16-01 Thermococcus gammatolerans strain EJ3-01

Wiley-Blackwell and Society for Applied Microbiology Page 441 of 848

Lactobacillus plantarum strain JDM1-01 Streptococcus gallolyticus strain UCN34-01 Fusobacterium nucleatum subsp. nucleatum str. ATCC 25586-30 Methanococcus maripaludis strain C6-01 Corynebacterium glutamicum ATCC 13032-01 Mycobacterium tuberculosis strain F11-01 Lactobacillus brevis strain ATCC 367-08 Shigella sonnei strain Ss046-08 Streptococcus pyogenes MGAS8232-01 Shigella flexneri 5 strain 8401-01 Bacillus anthracis strainFor Ames-01 Peer Review Only Escherichia coli strain MG1655-01 Borrelia duttonii strain Ly-01 Halobacterium sp. NRC-1-01 Staphylococcus aureus subsp. aureus strain Mu3-01 Mycobacterium leprae strain TN-08 Pyrococcus abyssi strain GE5-01 Mycobacterium tuberculosis strain H37Ra-08 Corynebacterium urealyticum strain DSM 7109-01 Lactobacillus casei strain BL23-01 Acidaminococcus fermentans strain DSM 20731-30 Methanocaldococcus sp. FS406-22-01 Streptococcus pneumoniae str. R6-01 Methanoculleus marisnigri strain JR1-01 Listeria monocytogenes strain 08-5578-01 Mycobacterium bovis subsp. bovis str. AF2122/97-01 Lactobacillus helveticus strain DPC 4571-01 Bacillus thuringiensis serovar konkukian strain 97-27-01 Natronomonas pharaonis strain DSM 2160-01 Mycobacterium tuberculosis strain H37Rv-01 Mycobacterium tuberculosis strain H37Ra-01 Escherichia coli strain UTI89-08 Natrialba magadii strain ATCC 43099-01 Caldivirga maquilingensis strain IC-167-01 Haloterrigena turkmenica strain DSM 5511-08 Clostridium kluyveri strain NBRC 12016-01 Thermoplasma volcanium strain GSS1-01 Bacillus anthracis str. Sterne-01 Rickettsia rickettsii strain 'Sheila Smith'-30 Mycoplasma penetrans strain HF-2-01 Streptococcus pneumoniae strain Hungary19A-6-08 Lactobacillus reuteri strain DSM 20016-01 Thermococcus sibiricus strain MM 739-01 Ehrlichia ruminantium strain Gardel-08 Aster yellows witches'-broom phytoplasma str. AYWB-01 Haloferax volcanii strain DS2-30 Renibacterium salmoninarum strain ATCC 33209-30

Wiley-Blackwell and Society for Applied Microbiology Page 442 of 848

Halobacterium salinarum strain R1-01 Veillonella parvula strain DSM 2008-30 Mycobacterium leprae strain Br4923-01 Helicobacter pylori strain 26695-01 Streptococcus dysgalactiae subsp. equisimilis strain GGS_124-01 Streptococcus pneumoniae strain Hungary19A-6-01 Lactobacillus rhamnosus strain GG-01 Bifidobacterium longum str. NCC2705-08 Lactobacillus rhamnosus strain Lc 705-08 Methanosphaera stadtmanae strain DSM 3091-01 Streptococcus pyogenesFor strain Manfredo-01Peer Review Only Helicobacter mustelae strain 12198-08 Helicobacter pylori strain G27-01 Methanococcus maripaludis strain S2-01 Thermococcus onnurineus strain NA1-01 Shigella flexneri serotype 2a str. 301-30 Haloarcula marismortui strain ATCC 43049-01 Haloquadratum walsbyi strain DSM 16790-30 Mycoplasma genitalium strain G37-08 Thermosipho africanus strain TCF52B-30 Mesoplasma florum strain L1-08 Bacillus cereus strain ATCC 10987-01 Bacillus anthracis strain A0248-01 Streptococcus pyogenes MGAS8232-08 Clostridium kluyveri strain DSM 555-30 Sulfolobus islandicus strain L.S.2.15-01 Thermotoga sp. RKU-10-01 Bifidobacterium longum str. DJO10A-01 Clostridium botulinum A strain ATCC 19397-30 Pyrobaculum arsenaticum strain DSM 13514-01 Lactobacillus casei strain BL23-08 Lactobacillus rhamnosus strain Lc 705-01 Lactobacillus reuteri strain JCM 1112-30 Chlamydia trachomatis strain D/UW-3/CX-08 Sulfolobus tokodaii strain 7-01 Mesoplasma florum strain L1-01 Bacillus subtilis subsp. subtilis str. BGSC 1A700-08 Lactobacillus paracasei ATCC 334-01 Metallosphaera sedula strain DSM 5348-01 Salmonella enterica subsp. enterica serovar Paratypi A str. ATCC 9150-01 Haloferax volcanii strain DS2-01 Escherichia coli strain E24377A-30 Streptococcus mutans str. UA159-01 Streptococcus pyogenes MGAS8232-30 Haloterrigena turkmenica strain DSM 5511-01 Chlamydophila pneumoniae AR39-01 Mycobacterium leprae strain Br4923-08

Wiley-Blackwell and Society for Applied Microbiology Page 443 of 848

Lactobacillus johnsonii strain FI9785-08 Sulfolobus islandicus strain M.16.4-01 Sulfolobus islandicus strain L.D.8.5-01 Lactobacillus johnsonii NCC 533-08 Mycoplasma capricolum subsp. capricolum strain ATCC 27343-08 Sulfolobus solfataricus strain P2-01 Sulfolobus islandicus strain Y.N.15.51-01 Pyrococcus furiosus strain DSM 3638-08 Rickettsia akari strain Hartford-08 Chlamydophila pneumoniae J138-08 Bifidobacterium animalisFor subsp. Peerlactis strain Bl-04-08 Review Only Helicobacter pylori strain P12-01 Listeria monocytogenes strain 08-5923-01 Natranaerobius thermophilus strain JW/NM-WN-LF-30 Mycoplasma synoviae strain 53-01 Borrelia sp. PBi-08 Borrelia burgdorferi str. B31-08 Borrelia burgdorferi str. B31-01 Listeria monocytogenes strain 4b F2365-30 Schizoplasma hominis-01 Bacillus anthracis strain Ames-08 Escherichia coli strain K12 substrain DH10B-01 Campylobacter jejuni strain RM1221-08 Streptococcus pneumoniae strain CGSP14-08 Campylobacter hominis strain ATCC BAA-381-08 Staphylococcus aureus subsp. aureus N315-08 Bacillus cereus strain B4264-30 Staphylococcus lugdunensis strain HKU09-01-08 Bacillus cereus ATCC 14579-30 Bacillus thuringiensis serovar konkukian strain 97-27-08 Chlamydia trachomatis MoPn strain Nigg-08 Rickettsia conorii strain Malish 7-30 Sulfolobus islandicus strain M.14.25-01 Helicobacter pylori strain HPAG1-01 Chlamydophila pneumoniae TW183-01 Cryptobacterium curtum strain DSM 15641-30 Candidatus Desulforudis audaxviator strain MP104C-30 Candidatus Blochmannia floridanus-30 Chlamydophila pneumoniae CWL029-30 Rickettsia bellii strain RML369-C-30 Lactobacillus plantarum strain WCFS1-01 Borrelia duttonii strain Ly-08 Borrelia burgdorferi strain ZS7-30 Chlamydophila pneumoniae TW183-08 Streptococcus pneumoniae strain 70585-08 uncultured Termite group 1 bacterium phylotype Rs-D17-08 Methanococcus maripaludis strain C6-30

Wiley-Blackwell and Society for Applied Microbiology Page 444 of 848

Coxiella burnetii strain CbuG_Q212-30 Enterobacter cloacae subsp. cloacae strain ATCC 13047-01 Chlamydophila abortus str. S26/3-08 Aminobacterium colombiense strain DSM 12261-30 Streptomyces rochei Berger et al. 1953-01 Methanocaldococcus fervens strain AG86-30 Bacillus anthracis strain CDC 684-30 Staphylococcus aureus subsp. aureus COL-30 Mycoplasma penetrans strain HF-2-08 korarchaeote OPF1-KOR-30 Helicobacter pylori strainFor G27-30 Peer Review Only Borrelia hermsii strain DAH-08 Mycoplasma gallisepticum strain R(low)-01 Escherichia coli strain W3110-01 Coprothermobacter proteolyticus DSM 5265-01 Sulfolobus islandicus strain M.14.25-08 Lactobacillus delbrueckii subsp. bulgaricus strain ATCC 11842-30 Mycobacterium leprae strain Br4923-30 Bifidobacterium lactis AD011-01 Pyrococcus furiosus strain DSM 3638-30 Brachybacterium faecium strain DSM 4810-30 Sulfolobus acidocaldarius NCIB 11770-08 Escherichia coli strain MG1655-08 Helicobacter pylori strain 26695-08 Pyrobaculum islandicum strain DSM 4184-01 Lactobacillus delbrueckii subsp. bulgaricus strain ATCC 11842-08 Lactobacillus sakei subsp. sakei strain 23K-30 Tropheryma whipplei strain Twist-01 Tropheryma whipplei strain Twist-30 Neorickettsia sennetsu str. Miyayama-30 Streptococcus pyogenes str. MGAS315-30 Mycobacterium tuberculosis strain H37Ra-30 Staphylococcus aureus subsp. aureus strain ED98-30 Methanospirillum hungatei strain JF-1-30 Dehalococcoides sp. BAV1-08 Halothermothrix orenii strain H 168-30 Candidatus Blochmannia pennsylvanicus strain BPEN-30 Streptococcus pyogenes strain MGAS10750-01 Pyrobaculum aerophilum strain IM2-01 Dehalococcoides ethenogenes strain 195-08 Streptococcus agalactiae str. A909-01 Streptococcus sanguinis strain SK36-30 Coprothermobacter proteolyticus DSM 5265-30 Staphylococcus epidermis RP62A-30 Leuconostoc mesenteroides subsp. mesenteroides strain ATCC 8293-08 Streptococcus agalactiae str. A909-08 Ignicoccus sp. Kin4-I-08

Wiley-Blackwell and Society for Applied Microbiology Page 445 of 848

Mycobacterium tuberculosis strain F11-30 Campylobacter jejuni subsp. doylei strain 269.97-30 Clostridium botulinum A strain ATCC 19397-08 Atopobium parvulum strain DSM 20469-30 Staphylococcus aureus subsp. aureus strain Newman-01 Campylobacter jejuni subsp. jejuni strain NCTC 11168-30 Proteinoruptor kamchatkensis 1221n-08 Campylobacter fetus subsp. fetus strain 82-40-30 Sulfolobus islandicus strain Y.G.57.14-01 Staphylothermus marinus strain F1-01 uncultured Termite Forgroup 1 bacterium Peer phylotype Review Rs-D17-30 Only Staphylococcus aureus subsp. aureus strain MRSA252-08 Mycobacterium bovis BCG strain Pasteur 1173P2-08 Thermotoga neapolitana NS-E-30 Mycobacterium bovis BCG strain Pasteur 1173P2-30 Sulfolobus islandicus strain M.16.27-01 Streptococcus pneumoniae str. R6-30 Rickettsia peacockii strain Rustic-30 Onion yellows phytoplasma str. 'onion yellows'-08 Streptococcus pyogenes strain NZ131-08 Borrelia recurrentis strain A1-30 Dehalococcoides ethenogenes strain 195-30 Mycobacterium bovis BCG strain Pasteur 1173P2-01 Thermococcus sibiricus strain MM 739-30 Lactobacillus rhamnosus strain Lc 705-30 Thermotoga sp. RKU-1-30 Escherichia coli strain HS-08 Thermoanaerobacter pseudethanolicus strain ATCC 33223-30 Ammonifex degensii strain KC4-30 Thermoanaerobacter italicus strain Ab9-30 Rickettsia africae ESF-5-30 Yersinia pestis biovar Orientalis strain IP275-01 Caldivirga maquilingensis strain IC-167-30 Streptococcus pneumoniae strain Taiwan19F-14-30 Haloferax volcanii strain DS2-08 Helicobacter pylori strain J99-08 Helicobacter pylori strain P12-30 Treponema pallidum subsp. pallidum strain SS14-01 Carsonella-Pv-08 Aeropyrum pernix strain K1-30 Methanocaldococcus sp. FS406-22-30 Ignicoccus sp. Kin4-I-30 Methanopyrus kandleri str. AV19-30 Sulfolobus tokodaii strain 7-08 Streptococcus thermophilus strain CNRZ1066-30 Streptococcus pyogenes strain SF370-08 Campylobacter hominis strain ATCC BAA-381-30

Wiley-Blackwell and Society for Applied Microbiology Page 446 of 848

Lactobacillus crispatus strain ST1-30 Staphylococcus saprophyticus subsp. saprophyticus strain ATCC 15305-30 Clostridium botulinum A strain ATCC 3502-08 Mycoplasma crocodyli strain MP145-01 Dictyoglomus turgidum strain DSM 6724-30 Escherichia coli O111:H- strain 11128-30 Lactobacillus casei strain BL23-30 Campylobacter jejuni subsp. jejuni strain 81116-30 Campylobacter curvus strain 525.92-30 Escherichia coli strain MG1655-30 Staphylococcus epidermidisFor ATCC Peer 12228-30 Review Only Dehalococcoides sp. BAV1-30 Escherichia coli strain 536-08 Brucella melitensis biovar Abortus strain 2308-01 Chlamydia trachomatis strain B/TZ1A828/OT-30 Salmonella enterica subsp. arizonae serovar 62:z4;z23:---08 Streptococcus uberis str. 0140J-08 Escherichia coli strain SMS-3-5-30 Listeria monocytogenes strain EGD-e-30 Thermotoga maritima strain MSB8-30 Campylobacter jejuni strain RM1221-30 Methanocaldococcus sp. FS406-22-08 Listeria innocua strain Clip11262-30 Aquifex aeolicus str. VF5-30 Paracoccus aminophilus Urakami et al. 1990;-01 Bacillus cereus strain E33L-08 Sulfolobus acidocaldarius NCIB 11770-01 Francisella tularensis subsp. holarctica strain FTNF002-00-01 Pyrobaculum aerophilum strain IM2-08 Sphingomonas sp. KA1-01 Salmonella enterica subsp. arizonae serovar 62:z4;z23:---01 not Oenococcus oeni MCW-30 Thermoanaerobacter pseudethanolicus strain ATCC 33223-08 Thermoproteus neutrophilus strain V24Sta-30 Salmonella enterica subsp. arizonae serovar 62:z4;z23:---30 Pyrobaculum arsenaticum strain DSM 13514-08 Bifidobacterium dentium strain Bd1-30 Treponema pallidum subsp. pallidum str. Nichols-08 Bacillus cereus strain AH820-30 Lactobacillus sakei subsp. sakei strain 23K-08 Staphylococcus aureus subsp. aureus str. MW2-08

Wiley-Blackwell and Society for Applied Microbiology Page 447 of 848

Table S3. Contributions of individual OTUs to variance between the North and South zones. Average abundance South (Standardised and transformed) 0 0 0.01 0.04 1.97 0.82 0.34 0.74 For Peer Review2.32 Only 0.62 0.48 0.49 1.01 0.38 0.57 0.45 0.72 0.46 0.76 0.63 0.75 0.47 0.34 0.22 0.61 0.27 0.59 0.29 0.25 0.59 0.49 0.22 0.51 0.56 0.37 0.4 0.53 0.28 0.27 0.43 0.24 0.35 0.2 0.42 0.49

Wiley-Blackwell and Society for Applied Microbiology Page 448 of 848

0.35 0.2 0.48 0.44 0.2 0.29 0.3 0.27 0.29 0.34 For Peer Review0.15 Only 0.17 0.17 0.2 0.33 0.23 0.33 0.16 0.13 0.21 3.33 0.09 0.08 0 0.12 0.2 0.18 0.13 0.18 0.16 0.27 0.16 0 0.13 0.19 0.21 0.12 0.06 0.11 0.1 0.15 0.15 0.1 0.09 0.13 0.09 0.17

Wiley-Blackwell and Society for Applied Microbiology Page 449 of 848

0.17 0.11 0.13 0.19 0.08 0.11 0.11 0.08 0.07 0.06 For Peer Review0.13 Only 0 0.01 0.1 0.01 0.07 0.06 0.02 0.07 0.09 0.09 0 0.1 0.11 0.06 0 0.07 0.12 0.07 0.07 0.02 0.09 0.1 0 0.1 0.07 0.08 0.09 0.06 0.05 0.06 0.09 0.06 0.07 0.03 0.06 0.1

Wiley-Blackwell and Society for Applied Microbiology Page 450 of 848

0.05 0.09 0.11 0.04 0.05 0.05 0.08 0.05 0.07 0.06 For Peer Review0.06 Only 0.06 0.07 0.07 0.05 0.06 0.07 0.06 0.05 0.07 0.05 0.06 0.04 0.05 0.02 0.04 0.03 0.06 0.04 0.01 0.04 0.05 0.04 0.06 0.06 0.03 0.05 0 0.06 0.06 0.02 0.04 0.04 0.03 0.04 0.05 0.05

Wiley-Blackwell and Society for Applied Microbiology Page 451 of 848

0.03 0.01 0.05 0.05 0.03 0.03 0.03 0.04 0.03 0.04 For Peer Review0.04 Only 0.04 0.04 0.04 0.03 0.01 0.02 0.04 0.04 0.05 0.04 0.04 0.05 0.04 0.04 0.03 0.03 0.04 0.04 0.04 0.03 0.03 0.04 0.04 0.04 0.04 0.03 0.01 0.03 0.03 0.03 0.04 0.01 0.02 0.04 0.04 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 452 of 848

0.04 0.04 0 0.03 0.02 0.04 0.01 0.02 0.02 0.03 For Peer Review0.02 Only 0.03 0.04 0.03 0.03 0.02 0.02 0.03 0.05 0.01 0.03 0.02 0.04 0.02 0.03 0.03 0.02 0.02 0.04 0.02 0.03 0.01 0.03 0.02 0.02 0.02 0.03 0.01 0.01 0.03 0.01 0.03 0.03 0.03 0.04 0.02 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 453 of 848

0.03 0.02 0.03 0.03 0.02 0.02 0.02 0.02 0.02 0.02 For Peer Review0.01 Only 0.02 0.02 0.03 0.03 0.02 0.02 0.04 0.03 0.02 0.02 0.02 0.02 0.02 0.01 0.03 0.02 0.02 0.02 0.03 0.04 0.02 0.01 0.02 0.03 0.01 0.02 0.02 0.03 0.02 0.03 0.03 0.03 0.02 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 454 of 848

0.02 0.02 0.01 0.02 0.02 0.03 0.03 0.02 0.03 0.03 For Peer Review0.01 Only 0.02 0.02 0.03 0.02 0.02 0.02 0.02 0.03 0.03 0.02 0.01 0.02 0.02 0.02 0.02 0.03 0.03 0.02 0.03 0.02 0.03 0.02 0.02 0.03 0.02 0.01 0 0.02 0.02 0.02 0.01 0.03 0.02 0.03 0.02 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 455 of 848

0.01 0 0.02 0.02 0.02 0.01 0.02 0.01 0 0.02 For Peer Review0.01 Only 0.01 0.02 0.04 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.03 0.01 0.01 0.01 0 0.02 0.02 0.02 0 0.02 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0.02 0.02 0.01 0.01 0.01 0.01 0.02 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 456 of 848

0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.01 0.01 For Peer Review0.01 Only 0.02 0.01 0.01 0.01 0.02 0.02 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.02 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 457 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.03 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.02 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.02 0.02 0.01 0 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.02 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 458 of 848

0 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0 0.01 For Peer Review0.01 Only 0 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0

Wiley-Blackwell and Society for Applied Microbiology Page 459 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 For Peer Review0.01 Only 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 460 of 848

0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 For Peer Review0 Only 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 461 of 848

0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 For Peer Review0.01 Only 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 462 of 848

0 0.01 0.01 0.01 0 0 0.01 0.01 0.01 0.01 For Peer Review0 Only 0 0.01 0 0 0 0 0.01 0.01 0 0 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0

Wiley-Blackwell and Society for Applied Microbiology Page 463 of 848

0.01 0.01 0 0 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0 Only 0 0.01 0.01 0.01 0 0 0 0 0 0 0 0 0 0 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0 0.01 0.01 0 0 0 0 0.01 0 0.01 0

Wiley-Blackwell and Society for Applied Microbiology Page 464 of 848

0 0.01 0.01 0 0 0.01 0.01 0 0.01 0 For Peer Review0.01 Only 0 0 0 0 0.01 0 0.01 0.01 0 0.01 0.01 0 0 0 0.01 0 0.01 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0.01 0

Wiley-Blackwell and Society for Applied Microbiology Page 465 of 848

0 0 0 0 0.01 0 0.01 0 0 0.01 For Peer Review0.01 Only 0 0 0.01 0 0 0.01 0.01 0 0.01 0.01 0 0 0.01 0 0 0.01 0.01 0 0 0 0.01 0 0 0 0 0.01 0 0 0 0 0 0 0.01 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 466 of 848

0 0 0 0 0 0.01 0 0 0 0 For Peer Review0 Only 0 0.01 0.01 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 467 of 848

0 0 0.01 0 0.01 0.01 0.01 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0.01 0 0.01 0 0.01 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 468 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0.01 Only 0 0.01 0.01 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0.01 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 469 of 848

0 0 0 0 0 0.01 0 0 0.01 0 For Peer Review0 Only 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 470 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 471 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 472 of 848

0 0 0.01 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 473 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 474 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 475 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 476 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 477 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 478 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 479 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 480 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 481 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 482 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 483 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 484 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 485 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 486 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 487 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 488 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 489 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 490 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 491 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 492 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 493 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 494 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 495 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 496 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 497 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 498 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 499 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 500 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 501 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 502 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 503 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 504 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 505 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 506 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 507 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 508 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 509 of 848

0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 510 of 848

Average abundance North (Standardised and transformed) Contribution to variance (%) 1.08 2.88 1.04 2.81 0.98 2.59 0.76 2.03 2.4 1.97 0.25 1.57 0.66 1.32 0.25 1.32 For Peer Review2.48 Only 1.32 0.18 1.2 0.04 1.13 0.06 1.1 0.81 1.08 0.54 1.08 0.19 1.04 0.18 0.95 0.43 0.94 0.11 0.92 0.54 0.91 0.32 0.89 0.69 0.86 0.19 0.84 0.21 0.82 0.33 0.77 0.4 0.74 0.01 0.72 0.59 0.71 0.02 0.71 0.01 0.7 0.55 0.69 0.29 0.68 0.16 0.67 0.42 0.67 0.48 0.64 0.14 0.63 0.18 0.62 0.44 0.61 0.05 0.6 0.47 0.6 0.33 0.6 0.12 0.59 0.13 0.58 0 0.58 0.39 0.57 0.69 0.56

Wiley-Blackwell and Society for Applied Microbiology Page 511 of 848

0.18 0.53 0 0.53 0.47 0.52 0.35 0.52 0.02 0.51 0.29 0.5 0.2 0.49 0.13 0.47 0.13 0.46 0.2 0.44 For Peer Review0.27 Only 0.38 0.19 0.37 0.03 0.37 0.07 0.36 0.23 0.36 0.11 0.35 0.26 0.34 0.05 0.34 0.08 0.34 0.16 0.34 3.44 0.33 0.09 0.33 0.12 0.32 0.11 0.3 0.04 0.29 0.11 0.29 0.14 0.29 0.02 0.28 0.08 0.27 0.07 0.27 0.23 0.26 0.17 0.26 0.1 0.26 0.03 0.26 0.13 0.25 0.14 0.25 0.02 0.25 0.13 0.25 0.04 0.25 0.03 0.24 0.06 0.24 0.11 0.24 0.11 0.24 0.03 0.23 0.04 0.22 0.02 0.22 0.14 0.22

Wiley-Blackwell and Society for Applied Microbiology Page 512 of 848

0.14 0.21 0.08 0.21 0.12 0.21 0.14 0.21 0.02 0.2 0.11 0.2 0.13 0.2 0.11 0.2 0.01 0.19 0.04 0.18 For Peer Review0.07 Only 0.18 0.07 0.17 0.07 0.17 0.08 0.17 0.06 0.16 0.01 0.16 0.04 0.16 0.06 0.16 0.01 0.16 0.03 0.16 0.03 0.16 0.06 0.15 0.05 0.15 0.09 0.15 0.01 0.15 0.06 0.15 0.07 0.15 0.08 0.15 0.02 0.15 0.01 0.15 0.06 0.14 0.03 0.14 0.1 0.14 0.05 0.14 0.05 0.14 0.07 0.14 0.02 0.14 0.04 0.14 0.01 0.14 0.02 0.14 0.01 0.13 0.09 0.13 0.01 0.13 0.02 0.13 0.05 0.13 0.02 0.13 0.1 0.13

Wiley-Blackwell and Society for Applied Microbiology Page 513 of 848

0 0.13 0.09 0.13 0.08 0.13 0.05 0.13 0.06 0.13 0.02 0.13 0.06 0.13 0.05 0.13 0.06 0.13 0.02 0.12 For Peer Review0.01 Only 0.12 0.05 0.12 0.05 0.12 0.02 0.12 0.02 0.12 0.01 0.12 0.04 0.12 0.01 0.12 0.01 0.12 0.03 0.12 0.01 0.11 0.02 0.11 0.01 0.11 0.05 0.11 0.04 0.11 0.01 0.1 0.04 0.1 0.02 0.1 0.01 0.1 0.04 0.1 0.01 0.1 0.02 0.1 0 0.1 0.02 0.1 0.06 0.1 0.03 0.09 0.01 0.09 0.04 0.09 0.03 0.09 0.04 0.09 0.04 0.09 0.03 0.09 0.01 0.09 0.03 0.09 0.04 0.09 0.01 0.09 0.03 0.09

Wiley-Blackwell and Society for Applied Microbiology Page 514 of 848

0.04 0.09 0.03 0.09 0.02 0.09 0.03 0.09 0.03 0.09 0.01 0.09 0.01 0.08 0.01 0.08 0 0.08 0.01 0.08 For Peer Review0.01 Only 0.08 0.05 0.08 0.01 0.08 0.01 0.08 0.01 0.08 0.03 0.08 0.03 0.08 0.03 0.08 0.01 0.08 0.02 0.08 0.02 0.08 0.03 0.08 0.02 0.08 0.01 0.08 0.02 0.08 0.02 0.08 0 0.08 0.01 0.08 0.01 0.08 0.03 0.08 0.02 0.08 0.01 0.08 0.01 0.08 0.02 0.08 0.03 0.07 0.02 0.07 0.01 0.07 0.02 0.07 0.03 0.07 0.01 0.07 0.01 0.07 0.01 0.07 0.03 0.07 0.03 0.07 0.02 0.07 0.01 0.07 0 0.07

Wiley-Blackwell and Society for Applied Microbiology Page 515 of 848

0.02 0.07 0.01 0.07 0.03 0.07 0.01 0.07 0.01 0.06 0.02 0.06 0.04 0.06 0.02 0.06 0 0.06 0.01 0.06 For Peer Review0.01 Only 0.06 0.01 0.06 0.02 0.06 0 0.06 0.02 0.06 0.03 0.06 0.04 0.06 0.01 0.06 0.04 0.06 0.02 0.06 0 0.06 0.01 0.06 0.04 0.06 0.03 0.06 0.01 0.06 0.02 0.06 0.01 0.06 0.02 0.06 0.02 0.06 0.01 0.06 0.02 0.06 0.02 0.06 0.01 0.06 0.02 0.06 0.01 0.06 0.01 0.06 0.01 0.06 0.02 0.06 0.02 0.06 0.02 0.06 0.02 0.06 0.01 0.06 0.01 0.06 0.01 0.06 0.02 0.06 0 0.05 0.02 0.05

Wiley-Blackwell and Society for Applied Microbiology Page 516 of 848

0.01 0.05 0 0.05 0.02 0.05 0.02 0.05 0 0.05 0.01 0.05 0 0.05 0 0.05 0 0.05 0.01 0.05 For Peer Review0.02 Only 0.05 0.01 0.05 0 0.05 0.02 0.05 0.01 0.05 0 0.05 0.01 0.05 0.03 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0 0.05 0 0.05 0 0.05 0.02 0.05 0.01 0.05 0.01 0.05 0 0.05 0 0.05 0.01 0.05 0.03 0.05 0 0.05 0.02 0.05 0.01 0.05 0.02 0.05 0.01 0.05 0.01 0.05 0 0.05 0.02 0.05 0.02 0.05 0.01 0.05 0.01 0.05 0.02 0.05 0 0.05 0 0.05 0.01 0.05 0 0.05

Wiley-Blackwell and Society for Applied Microbiology Page 517 of 848

0.01 0.05 0 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.04 0.01 0.04 0.01 0.04 0.01 0.04 For Peer Review0.01 Only 0.04 0 0.04 0.02 0.04 0.01 0.04 0 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.02 0.04 0.02 0.04 0 0.04 0.01 0.04 0 0.04 0.01 0.04 0.02 0.04 0.01 0.04 0.01 0.04 0.02 0.04 0.01 0.04 0.02 0.04 0 0.04 0.02 0.04 0.01 0.04 0 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.02 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.02 0.04 0.01 0.04 0.02 0.04 0.02 0.04 0.01 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 518 of 848

0.02 0.04 0.02 0.04 0.01 0.04 0.01 0.04 0.02 0.04 0.01 0.04 0 0.04 0 0.04 0.01 0.04 0.01 0.04 For Peer Review0.01 Only 0.04 0.01 0.04 0.01 0.04 0.03 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0 0.04 0 0.04 0.01 0.04 0.02 0.04 0.02 0.04 0.02 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.02 0.04 0.02 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0 0.04 0.01 0.04 0 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0.01 0.04 0 0.04 0 0.03 0.01 0.03 0.01 0.03 0 0.03 0 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 519 of 848

0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.02 0.03 0.01 0.03 0 0.03 0 0.03 0 0.03 For Peer Review0.01 Only 0.03 0.02 0.03 0.01 0.03 0.01 0.03 0 0.03 0 0.03 0.01 0.03 0.02 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.02 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0 0.03 0 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0 0.03 0.01 0.03 0.01 0.03 0 0.03 0.01 0.03 0 0.03 0 0.03 0.01 0.03 0.02 0.03 0.01 0.03 0.01 0.03 0 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 520 of 848

0 0.03 0.01 0.03 0 0.03 0.01 0.03 0 0.03 0.01 0.03 0 0.03 0.02 0.03 0 0.03 0.02 0.03 For Peer Review0 Only 0.03 0 0.03 0 0.03 0.01 0.03 0 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0 0.03 0 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0 0.03 0.01 0.03 0 0.03 0.01 0.03 0.02 0.03 0.01 0.03 0 0.03 0.01 0.03 0.01 0.03 0 0.03 0.01 0.03 0 0.03 0.01 0.03 0 0.03 0 0.03 0 0.03 0 0.02 0.01 0.02 0 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 521 of 848

0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0.02 0.02 0 0.02 0.01 0.02 0.01 0.02 0.01 0.02 For Peer Review0 Only 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 522 of 848

0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 For Peer Review0.01 Only 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0.01 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0.01 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 523 of 848

0.01 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 For Peer Review0 Only 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 524 of 848

0.01 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0 0.02 For Peer Review0.01 Only 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 525 of 848

0 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 526 of 848

0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 527 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 528 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 529 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 530 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 531 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 532 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 533 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 534 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 535 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 536 of 848

0 0.01 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 537 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 538 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 539 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 540 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 541 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 542 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 543 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 544 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 545 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 546 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 547 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 548 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 549 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 550 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 551 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 552 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 553 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 554 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 555 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 556 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 557 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 558 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 559 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 560 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 561 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 562 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 563 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 564 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 565 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 566 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 567 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 568 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 569 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 570 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 571 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 572 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 573 of 848

Table S4. Genes related to aerobic respiration annotated in scaffolds from assemblies of GSO-EOSA-1 affiliated reads. Gene Organism Scaffold ID Scaffold Length (bp) Match Identity (%) ubiquinol-cytochromeCandidatus cVesicomyosocius scf7180000045312reductase iron-sulfur okutanii subunit HA 313 69.07 ubiquinol-cytochromeCandidatus cRuthia scf7180000045312reductase; magnifica iron-sulfur str. Cm subunit (Calyptogena313 magnifica) 64.95 ubiquinol-cytochromeShewanella c denitrificans scf7180000045312reductase; iron-sulfur OS217 subunit 313 55.67 ubiquinol-cytochromePseudoalteromonas c scf7180000045312reductase; atlantica iron-sulfur T6c subunit 313 55.79 ubiquinol-cytochromeGlaciecola agarilyticac scf7180000045312reductase; 4H-3-7+YE-5 iron-sulfur subunit 313 55.79 cytochromeShewanella c biogenesis piezotoleransscf7180000045334 protein CcmA WP3 551 46.71 CytochromeBeggiatoa c-type biogenesis sp.scf7180000045334 PS protein CcmB 488 51.88 ubiquinol-cytochromeCandidatus cVesicomyosocius scf7180000045359reductase iron-sulfur okutanii subunit HA 181 84.21 ubiquinol-cytochromeCandidatusFor cRuthia scf7180000045359reductase; magnifica Peer iron-sulfur str. Cm subunit (CalyptogenaReview181 magnifica) Only84.21 ubiquinol-cytochromeKingella denitrificans c scf7180000045359reductase ATCC iron-sulfur 33394 subunit 181 81.82 ubiquinol-cytochromeKingella kingae c scf7180000045359reductase ATCC 23330 iron-sulfur subunit 181 81.82 cytochromeCandidatus b/b6 domain-containing Ruthiascf7180000045359 magnifica protein str. Cm (Calyptogena1124 magnifica) 78.98 ubiquinol-cytochromeCandidatus cVesicomyosocius scf7180000045359reductase cytochrome okutanii b subunitHA 1124 77.09 cytochromeThiobacillus B subunit of denitrificansscf7180000045359 cytochrome ATCC bc1 25259 1124 67.39 CytochromeMethylovorus b/b6 domain-containingscf7180000045359 glucosetrophus protein SIP3-4 1124 64.34 CytochromeAllochromatium b/b6 domain-containingscf7180000045359 vinosum DSMprotein 180 1124 63.83 ubiquinol-cytochromeCandidatus cVesicomyosocius scf7180000045359reductase cytochrome okutanii c1 HA subunit599 59.78 ubiquinol cytochromeXanthomonas C scf7180000045359oxidoreductase; campestris pv. musacearumcytochrome C1 NCPPB4381 599subunit 52.2 ubiquinol cytochromeXanthomonas C scf7180000045359oxidoreductase; oryzae pv. oryzae cytochrome KACC10331 C1 599subunit 50.73 ubiquinol cytochromeXanthomonas C scf7180000045359oxidoreductase; oryzae pv. oryzicola cytochrome BLS256 C1 599subunit 50.73 ubiquinol cytochromeXanthomonas C scf7180000045359oxidoreductase; campestris pv. vasculorumcytochrome NCPPB702C1 599subunit 49.52 CytochromeLimnobacter c oxidase; subunit scf7180000045367sp. MED105 II:Cytochrome c; class I:Cytochrome281 C oxidase57.73 subunit II; transmembrane region cytochromeNitrosospira c oxidase subunit scf7180000045367multiformis II ATCC 25196 281 55.32 cytochromeNitrosospira c oxidase subunit scf7180000045367multiformis II ATCC 25196 281 55.32 CytochromeOxalobacteraceae c oxidase polypeptidescf7180000045367 bacterium II IMCC9480 281 55.43 CytochromeBurkholderia c oxidase; subunitscf7180000045367 gladioli II BSR3 281 52.69 cytochrome-cCandidatus oxidase Ruthiascf7180000045367 magnifica str. Cm (Calyptogena1208 magnifica) 90.02 cytochromeCandidatus c oxidase subunit Vesicomyosociusscf7180000045367 I okutanii HA 1208 89.53 cytochromeKangiella c oxidase koreensis subunitscf7180000045367 I DSM 16069 1208 78.79 CytochromePseudoalteromonas c oxidase; subunitscf7180000045367 I tunicata D2 1208 77.78 cytochromeTeredinibacter C oxidase subunitscf7180000045367 turnerae I T7901 1208 78.73 cytochrome-cCandidatus oxidase Ruthiascf7180000045367 magnifica str. Cm (Calyptogena263 magnifica) 73.26 cytochromeCandidatus c oxidase subunit Vesicomyosociusscf7180000045367 I okutanii HA 263 70.93 cytochrome-cHahella oxidase chejuensis subunitscf7180000045367 IKCTC 2396 263 66.67 cytochromeShewanella c oxidase subunit woodyiscf7180000045367 I ATCC 51908 263 66.22 cytochrome-cNitrosospira oxidase scf7180000045367multiformis ATCC 25196 263 67.57 cytochromeCandidatus c oxidase assembly Ruthiascf7180000045367 magnifica protein CtaG/Cox11 str. Cm (Calyptogena524 magnifica) 72.67 cytochromeCandidatus c oxidase assembly Vesicomyosociusscf7180000045367 protein okutanii HA 524 66.86 cytochromegamma c oxidase proteobacterium assemblyscf7180000045367 protein HTCC5015 CtaG/Cox11 524 47.14 cytochromeMethylotenera c oxidase assemblyscf7180000045367 versatilis protein 301 CtaG/Cox11 524 46.76 cytochromeMethylovorus c oxidase assemblyscf7180000045367 sp. MP688 protein ctag/cox11 524 47.83 cytochromeCandidatus c oxidase subunit Vesicomyosociusscf7180000045367 III okutanii HA 269 75.58 cytochromeCandidatus c oxidase; subunitRuthiascf7180000045367 magnifica III str. Cm (Calyptogena269 magnifica) 74.42 CytochromeNitrococcus c oxidase; subunit mobilisscf7180000045367 IIINb-231 269 64.63 cytochromeMethylococcus c oxidase subunitscf7180000045367 capsulatus III str. Bath 269 54.12

Wiley-Blackwell and Society for Applied Microbiology Page 574 of 848

cytochrome-cNitrosococcus oxidase scf7180000045367 halophilus Nc4 269 57.32 cytochromeCandidatus c oxidase subunit Vesicomyosociusscf7180000045367 III okutanii HA 596 72.22 cytochromeCandidatus c oxidase; subunitRuthiascf7180000045367 magnifica III str. Cm (Calyptogena596 magnifica) 71.07 cytochromeNitrosomonas c oxidase; subunitscf7180000045367 europaea III ATCC 19718 596 60.2 cytochromebeta c oxidase; proteobacterium subunitscf7180000045367 III KB13 596 58.88 cytochromeMethylophilales C oxidase subunitscf7180000045367 bacterium III HTCC2181 596 57 cytochromeuncultured C biogenesis SUP05scf7180000045387 protein cluster bacterium 443 53.44 cytochromeCandidatus c-type biogenesis Vesicomyosociusscf7180000045387 protein CcmH okutanii HA 443 55.73 cytochromeCandidatus C biogenesis Ruthiascf7180000045387 protein magnifica str. Cm (Calyptogena443 magnifica) 53.85 cytochromeThiocapsa C biogenesis marinascf7180000045387 protein 5811 443 42.4 cytochromeCandidatus c assemblyFor Ruthia proteinscf7180000045454 magnifica Peer str. Cm (CalyptogenaReview479 magnifica) Only56.69 cytochromeCandidatus c assembly Vesicomyosocius familyscf7180000045454 protein okutanii HA 479 56.13 cytochromeuncultured c assembly SUP05 proteinscf7180000045454 cluster bacterium 479 53.5 cytochromeMethylomicrobium c assembly proteinscf7180000045454 album BG8 479 47.14 cytochromeMethylomonas c-type biogenesisscf7180000045495 methanica protein MC09CcmI 812 30.51 cytochromeuncultured c-type biogenesis SUP05scf7180000045495 clusterprotein bacterium CcmF 1103 66.21 cytochromeCandidatus c-type biogenesis Ruthiascf7180000045495 magnificaprotein CcmF str. Cm (Calyptogena1103 magnifica) 62.84 cytochromeCandidatus c-type biogenesis Vesicomyosociusscf7180000045495 protein CcmF okutanii HA 1103 62.91 cytochromeDechloromonas c-type biogenesisscf7180000045495 aromatica protein CcmFRCB 1103 49.35 cytochromeNitrosomonas c-type biogenesisscf7180000045495 europaea protein ATCC (CcmF) 19718 1103 48.27 cytochromeuncultured c oxidase assembly SUP05scf7180000045517 cluster protein bacterium 968 60.93 cytochromeCandidatus oxidase assembly Ruthiascf7180000045517 magnifica str. Cm (Calyptogena968 magnifica) 59.6 cytochromeCandidatus c oxidase assembly Vesicomyosociusscf7180000045517 protein okutanii HA 968 56.25 cytochromeThioalkalivibrio oxidase assemblyscf7180000045517 sulfidophilus HL-EbGr7 968 48.29 cytochromeNitrosococcus oxidase assemblyscf7180000045517 watsonii C-113 968 47.46 cytochrome-cCandidatus oxidase Ruthiascf7180000045517 magnifica str. Cm (Calyptogena859 magnifica) 65.93 cytochromeCandidatus c oxidase subunit Vesicomyosociusscf7180000045517 II okutanii HA 859 64.49 cytochromeMarinomonas c oxidase; subunitscf7180000045517 sp. MED121 II 859 53.45 cytochromeMethylobacter c oxidase; subunitscf7180000045517 tundripaludum II SV96 859 49.48 cytochromeColwellia c oxidase; psychrerythraea subunitscf7180000045517 II 34H 859 56.15 cytochromeuncultured c-type biogenesis marinescf7180000045530 proteinbacterium CcmE 439 446 66.22 cytochromeCandidatus c-type biogenesis Ruthiascf7180000045530 magnificaprotein CcmE str. Cm (Calyptogena446 magnifica) 62.68 cytochromeCandidatus c-type biogenesis Vesicomyosociusscf7180000045530 protein CcmE okutanii HA 446 59.46 Cytochromeuncultured c-type biogenesis SUP05scf7180000045530 cluster protein bacterium ccmE 446 60 cytochromeMethylococcus c-type biogenesisscf7180000045530 capsulatus protein str.CcmE Bath 446 56.25 ABC transportergamma involved proteobacteriumscf7180000045931 in cytochrome IMCC2047 c biogenesis2C CcmB623 subunit 52.45 CytochromeBeggiatoa c-type biogenesis sp.scf7180000045931 PS protein CcmB 623 53.43 ABC transporterShewanella involved sp.scf7180000045931 in HN-41 cytochrome c biogenesis; CcmB623 subunit 54.95

Wiley-Blackwell and Society for Applied Microbiology Page 575 of 848

. Genes related to aerobic respiration annotated in scaffolds from assemblies of GSO-EOSA-1 affiliated reads. Match Alignment Length (bp) 97 97 97 95 95 167 160 57 For57 Peer Review Only 55 55 371 371 371 387 376 184 205 205 205 210 97 94 94 92 93 401 401 396 396 395 86 86 75 74 74 172 172 140 139 138 86 86 82 85

Wiley-Blackwell and Society for Applied Microbiology Page 576 of 848

82 198 197 196 197 200 131 131 130 125 For157 Peer Review Only 155 157 140 118 367 366 364 383 375 302 302 304 292 295 270 276 275 287 260 148 142 148 140 144 204 204 202

Wiley-Blackwell and Society for Applied Microbiology Page 577 of 848

Table S5. Contributions of KEGG ortholog groups to variance between the North and South zones. Ortholog group Average abundance South (standardised and log transformed) hypothetical protein-30 0.11 hypothetical protein-08 0.68 ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]-08 0.17 DNA polymerase III subunit alpha [EC:2.7.7.7]-08 0.25 hypothetical protein-01 0.26 proline dehydrogenase / delta 1-pyrroline-5-carboxylate-08 0.1 aminomethyltransferase [EC:2.1.2.10]-08 0.25 ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]-30 0.02 sarcosine oxidase; subunitFor alpha Peer[EC:1.5.3.1]-08 Review Only0.22 integrator complex subunit 6-30 0.07 multicomponent Na+:H+ antiporter subunit D-08 0.11 glutamine synthetase [EC:6.3.1.2]-08 0.24 pyruvate dehydrogenase E1 component [EC:1.2.4.1]-08 0.15 cobaltochelatase CobN [EC:6.6.1.2]-08 0.11 formate dehydrogenase; alpha subunit [EC:1.2.1.2]-08 0.15 DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]-30 0.03 glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14]-08 0.25 dimethylglycine dehydrogenase [EC:1.5.99.2]-08 0.17 flagellin-08 0.06 DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]-30 0.03 photosystem II PsbA protein-08 0.01 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]-08 0.17 glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14]-30 0.02 thymidylate synthase (FAD) [EC:2.1.1.148]-08 0.02 topoisomerase IV subunit A [EC:5.99.1.-]-08 0.11 DNA mismatch repair protein MutS-08 0.13 glutamate dehydrogenase [EC:1.4.1.2]-08 0.07 DNA polymerase I [EC:2.7.7.7]-01 0.12 GTP-binding protein-08 0.26 GTP-binding protein-30 0.03 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]-08 0.13 ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]-01 0.1 ATP-dependent helicase HrpA [EC:3.6.1.-]-08 0.06 methylmalonyl-CoA mutase [EC:5.4.99.2]-08 0.12 peptide/nickel transport system permease protein-08 0.17 penicillin-binding protein 1A [EC:2.4.1.- 3.4.-.-]-08 0.11 histidinol dehydrogenase [EC:1.1.1.23]-08 0.15 betaine-aldehyde dehydrogenase [EC:1.2.1.8]-08 0.07 DNA topoisomerase I [EC:5.99.1.2]-08 0.14 deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]-08 0.15 acyl-CoA dehydrogenase [EC:1.3.99.3]-08 0.14 DNA polymerase III subunit alpha [EC:2.7.7.7]-30 0.03 carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]-08 0.16 elongation factor EF-G [EC:3.6.5.3]-08 0.16 ATP-dependent RNA helicase DeaD-08 0.08

Wiley-Blackwell and Society for Applied Microbiology Page 578 of 848

3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]-08 0.11 branched-chain amino acid transport system permease protein-08 0.15 topoisomerase IV subunit B [EC:5.99.1.-]-08 0.1 DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]-08 0.24 phosphotransferase system; enzyme I; PtsP [EC:2.7.3.9]-08 0.08 glycine betaine/proline transport system permease protein-08 0.09 excinuclease ABC subunit A-08 0.18 transcription-repair coupling factor (superfamily II helicase)-08 0.14 simple sugar transport system permease protein-08 0.08 excinuclease ABC subunit A-30 0.02 pyruvate;orthophosphateFor dikinase Peer [EC:2.7.9.1]-08 Review Only0.06 choline dehydrogenase [EC:1.1.99.1]-08 0.1 molecular chaperone HscA-08 0.05 cellular nucleic acid-binding protein-30 0.04 2;4-dienoyl-CoA reductase (NADPH2) [EC:1.3.1.34]-08 0.06 glutamate-1-semialdehyde 2;1-aminomutase [EC:5.4.3.8]-08 0.07 photosystem I core protein Ib-30 0.05 ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]-08 0.03 branched-chain amino acid transport system ATP-binding protein-08 0.11 DNA polymerase I [EC:2.7.7.7]-30 0.02 inorganic phosphate transporter; PiT family-08 0.07 phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]-08 0.18 chaperonin GroEL-30 0.04 isoleucyl-tRNA synthetase [EC:6.1.1.5]-08 0.17 aminomethyltransferase [EC:2.1.2.10]-01 0.12 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+)-08 0.13 photosystem I core protein Ia-30 0.05 adenine-specific DNA-methyltransferase [EC:2.1.1.72]-30 0.06 DNA mismatch repair protein MutL-08 0.09 glutaminyl-tRNA synthetase [EC:6.1.1.18]-08 0.06 peptide/nickel transport system substrate-binding protein-08 0.15 RNA polymerase primary sigma factor-08 0.1 acetyl-CoA C-acetyltransferase [EC:2.3.1.9]-08 0.15 glycine betaine/proline transport system substrate-binding protein-08 0.08 phosphogluconate dehydratase [EC:4.2.1.12]-08 0.05 threonine dehydratase [EC:4.3.1.19]-08 0.11 GntR family transcriptional regulator / MocR family aminotransferase-08 0.05 sulfonate/nitrate/taurine transport system ATP-binding protein-08 0.06 single-stranded-DNA-specific exonuclease [EC:3.1.-.-]-08 0.09 oxaloacetate decarboxylase; alpha subunit [EC:4.1.1.3]-08 0.05 [protein-PII] uridylyltransferase [EC:2.7.7.59]-08 0.09 peptide chain release factor RF-3-08 0.08 glutaryl-CoA dehydrogenase [EC:1.3.99.7]-08 0.07 aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit A-08 0.12 ribonuclease R [EC:3.1.-.-]-08 0.11 peptide/nickel transport system ATP-binding protein-08 0.16 trk system potassium uptake protein TrkH-08 0.09

Wiley-Blackwell and Society for Applied Microbiology Page 579 of 848

ATP-dependent DNA helicase Rep [EC:3.6.1.-]-08 0.04 leucyl-tRNA synthetase [EC:6.1.1.4]-08 0.15 phenylacetic acid degradation protein-08 0.06 chaperonin GroEL-01 0.07 sn-glycerol 3-phosphate transport system substrate-binding protein-08 0.05 glycine dehydrogenase [EC:1.4.4.2]-30 0.02 translation initiation factor IF-2-08 0.16 DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]-01 0.11 inorganic pyrophosphatase [EC:3.6.1.1]-08 0.08 carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]-30 0.02 ATP-dependent Clp Forprotease ATP-binding Peer subunit Review ClpB-08 Only0.09 DNA gyrase subunit B [EC:5.99.1.3]-30 0.01 glycine betaine/proline transport system ATP-binding protein-08 0.08 5-methyltetrahydrofolate--homocysteine methyltransferase-08 0.11 glutamine synthetase [EC:6.3.1.2]-30 0.03 NADH dehydrogenase I subunit F [EC:1.6.5.3]-08 0.1 GTP-binding protein-01 0.1 preprotein translocase subunit SecA-08 0.18 magnesium chelatase subunit H [EC:6.6.1.1]-08 0 translation initiation factor IF-2-30 0.02 glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14]-01 0.11 cysteine synthase B [EC:2.5.1.47]-08 0.04 photosystem II PsbD protein-08 0.01 enoyl-CoA hydratase [EC:4.2.1.17]-08 0.11 trk system potassium uptake protein TrkA-08 0.08 glutamate synthase (ferredoxin) [EC:1.4.7.1]-08 0.03 L-aspartate oxidase [EC:1.4.3.16]-08 0.06 elongation factor EF-Tu [EC:3.6.5.3]-08 0.11 C4-dicarboxylate transporter; DctM subunit-08 0.03 5-methyltetrahydropteroyltriglutamate--homocysteine-08 0.06 succinate dehydrogenase flavoprotein subunit [EC:1.3.99.1]-08 0.12 cell division FtsH [EC:3.4.24.-]-08 0.11 DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]-01 0.11 agmatinase [EC:3.5.3.11]-08 0.09 peptide/nickel transport system permease protein-30 0.01 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD [EC:4.1.1.-]-08 0.05 urocanate hydratase [EC:4.2.1.49]-08 0.06 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]-08 0.14 multiple sugar transport system permease protein-08 0.09 small subunit ribosomal protein S1-08 0.11 sarcosine oxidase; subunit beta [EC:1.5.3.1]-08 0.1 DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.1.-]-08 0.13 methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.27]-08 0.08 isocitrate lyase [EC:4.1.3.1]-08 0.06 X-Pro aminopeptidase [EC:3.4.11.9]-08 0.09 ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]-30 0.01 DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]-08 0.25

Wiley-Blackwell and Society for Applied Microbiology Page 580 of 848

NAD(P) transhydrogenase [EC:1.6.1.1]-08 0.05 F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]-30 0.02 heavy-metal exporter; HME family-30 0 putrescine transport system permease protein-08 0.04 chaperonin GroEL-08 0.13 zinc protease [EC:3.4.99.-]-08 0.04 spermidine dehydrogenase [EC:1.5.99.6]-08 0.04 catalase/peroxidase [EC:1.11.1.6 1.11.1.7]-08 0.07 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]-30 0.02 ribosomal RNA large subunit methyltransferase L [EC:2.1.1.52]-08 0.04 cytochrome c oxidaseFor subunit I [EC:1.9.3.1]-30Peer Review Only0.02 DNA polymerase I [EC:2.7.7.7]-08 0.17 cytochrome c oxidase subunit I [EC:1.9.3.1]-08 0.14 5-dehydro-2-deoxygluconokinase [EC:2.7.1.92]-08 0.04 phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]-30 0.02 acetolactate synthase I/II/III large subunit [EC:2.2.1.6]-30 0.02 dihydroxy-acid dehydratase [EC:4.2.1.9]-08 0.15 DNA repair protein RecN (Recombination protein N)-08 0.07 elongation factor EF-G [EC:3.6.5.3]-30 0.02 acetyl-CoA synthetase [EC:6.2.1.1]-30 0.02 DNA polymerase III subunit alpha [EC:2.7.7.7]-01 0.1 fumarate hydratase; class II [EC:4.2.1.2]-08 0.05 fructose-bisphosphate aldolase; class II [EC:4.1.2.13]-08 0.06 phosphoenolpyruvate carboxylase [EC:4.1.1.31]-08 0.03 polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]-08 0.13 DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.1.-]-30 0.02 carboxyl-terminal processing protease [EC:3.4.21.102]-08 0.11 acetyl-CoA C-acetyltransferase [EC:2.3.1.9]-30 0.02 sn-glycerol 3-phosphate transport system permease protein-08 0.04 alcohol dehydrogenase [EC:1.1.1.1]-08 0.07 DNA segregation ATPase FtsK/SpoIIIE; S-DNA-T family-08 0.11 putative endopeptidase [EC:3.4.24.-]-08 0.03 glucose inhibited division protein A-30 0.01 deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]-30 0.02 glycyl-tRNA synthetase beta chain [EC:6.1.1.14]-08 0.09 transketolase [EC:2.2.1.1]-08 0.13 threonine aldolase [EC:4.1.2.5]-08 0.06 sarcosine oxidase; subunit alpha [EC:1.5.3.1]-30 0.02 dihydrodipicolinate synthase [EC:4.2.1.52]-08 0.07 glucose-6-phosphate isomerase [EC:5.3.1.9]-08 0.08 pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16-30 0.02 iron(III) transport system permease protein-08 0.09 acetolactate synthase I/II/III large subunit [EC:2.2.1.6]-08 0.16 single-strand DNA-binding protein-08 0.03 excinuclease ABC subunit A-01 0.08 dihydroxy-acid dehydratase [EC:4.2.1.9]-30 0.02 hippurate hydrolase [EC:3.5.1.32]-08 0.07

Wiley-Blackwell and Society for Applied Microbiology Page 581 of 848

DNA polymerase IV [EC:2.7.7.7]-08 0.05 DNA polymerase II [EC:2.7.7.7]-08 0.03 ATP-dependent DNA helicase RecQ [EC:3.6.1.-]-08 0.09 aminomethyltransferase [EC:2.1.2.10]-30 0.02 putative transposase-08 0.02 long-chain acyl-CoA synthetase [EC:6.2.1.3]-08 0.09 ribonuclease G [EC:3.1.26.-]-08 0.04 sarcosine oxidase; subunit alpha [EC:1.5.3.1]-01 0.11 DNA gyrase subunit A [EC:5.99.1.3]-08 0.14 O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]-08 0.09 threonyl-tRNA synthetaseFor [EC:6.1.1.3]-08 Peer Review Only0.12 L-lactate dehydrogenase (cytochrome) [EC:1.1.2.3]-08 0.06 transketolase [EC:2.2.1.1]-30 0.01 multiple sugar transport system substrate-binding protein-08 0.07 N-methylhydantoinase A [EC:3.5.2.14]-08 0.05 dihydropyrimidinase [EC:3.5.2.2]-08 0.05 chromosome segregation protein-30 0.02 L-serine dehydratase [EC:4.3.1.17]-08 0.04 ATP-dependent Lon protease [EC:3.4.21.53]-08 0.13 Fe-S cluster assembly protein SufB-08 0.05 ATP-dependent Lon protease [EC:3.4.21.53]-30 0.01 phytoene dehydrogenase [EC:1.14.99.-]-08 0.06 glycine dehydrogenase [EC:1.4.4.2]-08 0.15 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.-.-.-]-08 0.06 succinate dehydrogenase flavoprotein subunit [EC:1.3.99.1]-30 0.01 chromosome segregation protein-08 0.13 thiol:disulfide interchange protein DsbD [EC:1.8.1.8]-08 0.04 ATP-dependent HslUV protease ATP-binding subunit HslU-08 0.05 isoleucyl-tRNA synthetase [EC:6.1.1.5]-30 0.03 aconitate hydratase 2 [EC:4.2.1.3]-30 0.01 glutamine synthetase [EC:6.3.1.2]-01 0.09 sulfonate/nitrate/taurine transport system permease protein-08 0.05 DNA gyrase subunit B [EC:5.99.1.3]-08 0.15 phosphate:Na+ symporter; PNaS family-08 0.03 cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]-08 0.03 membrane-bound lytic murein transglycosylase D [EC:3.2.1.-]-08 0.04 phycoerythrin-associated linker protein-08 0 homoserine dehydrogenase [EC:1.1.1.3]-08 0.06 cell division protein FtsI (penicillin-binding protein 3)-08 0.09 acetoacetyl-CoA synthetase [EC:6.2.1.16]-08 0.04 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]-08 0.09 indolepyruvate ferredoxin oxidoreductase [EC:1.2.7.8]-08 0.05 electron transport complex protein RnfC-08 0.03 glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]-08 0.1 ATP-dependent helicase Lhr and Lhr-like helicase [EC:3.6.1.-]-08 0.03 2-isopropylmalate synthase [EC:2.3.3.13]-01 0.06 glycine hydroxymethyltransferase [EC:2.1.2.1]-08 0.07

Wiley-Blackwell and Society for Applied Microbiology Page 582 of 848

branched-chain amino acid transport system substrate-binding protein-08 0.09 2-isopropylmalate synthase [EC:2.3.3.13]-08 0.11 ubiquinol-cytochrome c reductase cytochrome b subunit [EC:1.10.2.2]-08 0.08 adenylylsulfate reductase; subunit A [EC:1.8.99.2]-08 0.04 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]-01 0.07 transcription termination factor Rho-08 0.09 -08 0.07 glycolate oxidase iron-sulfur subunit-08 0.04 signal recognition particle subunit SRP54-08 0.09 ATP-dependent DNA helicase DinG [EC:3.6.1.-]-08 0.04 aldehyde dehydrogenaseFor (NAD+) Peer [EC:1.2.1.3]-30 Review Only0.01 isoleucyl-tRNA synthetase [EC:6.1.1.5]-01 0.08 cell division protease FtsH [EC:3.4.24.-]-30 0.02 lipopolysaccharide export system permease protein-08 0.05 GTP-binding protein Era-08 0.05 peptide/nickel transport system ATP-binding protein-30 0.02 TatD DNase family protein [EC:3.1.21.-]-08 0.06 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP-08 0.1 GTP-binding protein LepA-08 0.12 preprotein translocase subunit SecA-30 0.04 multidrug resistance protein; MATE family-08 0.06 glutamate-ammonia-ligase adenylyltransferase [EC:2.7.7.42]-08 0.05 glutamate--cysteine ligase [EC:6.3.2.2]-08 0.07 cell division transport system permease protein-08 0.03 propionyl-CoA synthetase [EC:6.2.1.17]-08 0.06 NADH dehydrogenase I subunit 4 [EC:1.6.5.3]-08 0 branched-chain amino acid transport system permease protein-30 0.02 acetyl-CoA synthetase [EC:6.2.1.1]-08 0.11 iron complex outermembrane recepter protein-08 0.06 ATP-independent RNA helicase DbpA-08 0.03 RNA methyltransferase; TrmA family [EC:2.1.1.-]-08 0.04 alanyl-tRNA synthetase [EC:6.1.1.7]-30 0.02 cytochrome c-type biogenesis protein CcmF-08 0.08 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase /-08 0.07 catalase/peroxidase [EC:1.11.1.6 1.11.1.7]-30 0.01 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]-08 0.06 DNA polymerase III subunit epsilon [EC:2.7.7.7]-08 0.06 chromosome partitioning protein; ParB family-08 0.05 threonine synthase [EC:4.2.3.1]-08 0.07 glucosamine--fructose-6-phosphate aminotransferase (isomerizing)-08 0.11 preprotein translocase subunit SecA-01 0.08 polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]-30 0.01 iron complex outermembrane recepter protein-30 0.01 molecular chaperone HtpG-08 0.09 two-component system; NtrC family; C4-dicarboxylate transport sensor-08 0.03 ribosomal protein L11 methyltransferase [EC:2.1.1.-]-08 0.04 cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]-08 0.05

Wiley-Blackwell and Society for Applied Microbiology Page 583 of 848

amidophosphoribosyltransferase [EC:2.4.2.14]-30 0.01 O-succinylhomoserine sulfhydrylase [EC:2.5.1.-]-08 0.03 isocitrate dehydrogenase [EC:1.1.1.42]-30 0.01 cell division protein FtsA-08 0.06 outer membrane protein-08 0.09 UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]-08 0.05 phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]-08 0.11 cytochrome c peroxidase [EC:1.11.1.5]-08 0.04 valyl-tRNA synthetase [EC:6.1.1.9]-30 0.02 porphobilinogen synthase [EC:4.2.1.24]-08 0.07 gamma-glutamyltranspeptidaseFor Peer[EC:2.3.2.2]-30 Review Only0.01 LacI family transcriptional regulator-08 0.04 octaprenyl diphosphate synthase [EC:2.5.1.-]-08 0.06 putative spermidine/putrescine transport system ATP-binding protein-08 0.04 oxaloacetate decarboxylase; beta subunit [EC:4.1.1.3]-08 0.03 histidine ammonia-lyase [EC:4.3.1.3]-08 0.06 GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]-08 0.09 ATP-binding cassette; subfamily B; bacterial-30 0.01 phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]-01 0.08 cobaltochelatase CobT [EC:6.6.1.2]-08 0.03 aspartyl-tRNA synthetase [EC:6.1.1.12]-08 0.1 lysyl-tRNA synthetase; class II [EC:6.1.1.6]-08 0.07 fumarate hydratase; class I [EC:4.2.1.2]-08 0.03 dimethylaniline monooxygenase (N-oxide forming) [EC:1.14.13.8]-08 0.03 peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]-08 0.05 formate--tetrahydrofolate ligase [EC:6.3.4.3]-08 0.07 DNA gyrase subunit A [EC:5.99.1.3]-30 0.02 DNA polymerase III subunit beta [EC:2.7.7.7]-08 0.07 glycolate oxidase [EC:1.1.3.15]-08 0.05 dihydroorotase [EC:3.5.2.3]-30 0.01 valyl-tRNA synthetase [EC:6.1.1.9]-08 0.14 replicative DNA helicase [EC:3.6.1.-]-08 0.08 F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]-30 0.03 dipeptide transport system ATP-binding protein-08 0.02 carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]-01 0.09 inorganic pyrophosphatase [EC:3.6.1.1]-30 0.02 NADH dehydrogenase I subunit D [EC:1.6.5.3]-08 0.04 aconitate hydratase 1 [EC:4.2.1.3]-30 0.01 NADH dehydrogenase I subunit 5 [EC:1.6.5.3]-08 0 tyrosyl-tRNA synthetase [EC:6.1.1.1]-08 0.07 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4]-08 0.04 mercuric reductase [EC:1.16.1.1]-08 0.04 DNA topoisomerase I [EC:5.99.1.2]-01 0.07 amidophosphoribosyltransferase [EC:2.4.2.14]-08 0.09 branched-chain amino acid transport system permease protein-01 0.07 electron-transferring-flavoprotein dehydrogenase [EC:1.5.5.1]-08 0.06 exodeoxyribonuclease V beta subunit [EC:3.1.11.5]-08 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 584 of 848

3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4]-08 0.04 DNA polymerase III subunit delta [EC:2.7.7.7]-08 0.05 leucyl-tRNA synthetase [EC:6.1.1.4]-01 0.07 ubiquinone biosynthesis protein-08 0.08 isopentenyl-diphosphate delta-isomerase [EC:5.3.3.2]-08 0.03 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit-30 0.01 heavy-metal exporter; HME family-08 0.01 acyl-CoA dehydrogenase [EC:1.3.99.3]-30 0.01 ATP-binding cassette; sub-family F; member 3-08 0.08 enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9]-08 0.04 transcription-repair Forcoupling factor Peer (superfamily ReviewII helicase)-30 Only0.01 NAD(P) transhydrogenase subunit beta [EC:1.6.1.2]-08 0.08 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49]-08 0.05 soluble lytic murein transglycosylase [EC:3.2.1.-]-08 0.03 valine--pyruvate aminotransferase [EC:2.6.1.66]-08 0.02 malate synthase [EC:2.3.3.9]-08 0.09 adenosine deaminase [EC:3.5.4.4]-08 0.04 sarcosine dehydrogenase [EC:1.5.99.1]-08 0.04 DNA topoisomerase I [EC:5.99.1.2]-30 0.02 molecular chaperone DnaK-08 0.13 N-methylhydantoinase B [EC:3.5.2.14]-08 0.05 oligopeptidase A [EC:3.4.24.70]-08 0.04 elongation factor EF-G [EC:3.6.5.3]-01 0.06 hydrophobic/amphiphilic exporter-1 (mainly G- bacteria); HAE1 family-30 0.01 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]-08 0.06 ATP-binding cassette; subfamily B; bacterial-08 0.14 general L-amino acid transport system permease protein-08 0.07 aconitate hydratase 2 [EC:4.2.1.3]-08 0.09 kynureninase [EC:3.7.1.3]-08 0.04 glutamyl-tRNA reductase [EC:1.2.1.70]-08 0.05 preprotein translocase subunit SecY-08 0.08 flagellin-30 0.01 pyruvate carboxylase [EC:6.4.1.1]-08 0.05 peptide chain release factor RF-1-08 0.07 primosomal protein N' (replication factor Y) (superfamily II-08 0.1 excinuclease ABC subunit C-08 0.09 NADH dehydrogenase I subunit M [EC:1.6.5.3]-08 0.05 UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]-08 0.07 photosystem II PsbB protein-30 0.03 GTP pyrophosphokinase [EC:2.7.6.5]-08 0.06 peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]-08 0.05 ATP phosphoribosyltransferase regulatory subunit-08 0.04 glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]-08 0.05 DNA mismatch repair protein MutS-30 0.01 glucose-6-phosphate isomerase [EC:5.3.1.9]-30 0.01 penicillin-binding protein 1B [EC:2.4.1.129 3.4.-.-]-08 0.03 ribosomal RNA large subunit methyltransferase N [EC:2.1.1.-]-08 0.06

Wiley-Blackwell and Society for Applied Microbiology Page 585 of 848

iron complex transport system substrate-binding protein-08 0.04 phosphate transport system permease protein-08 0.03 iron(III) transport system substrate-binding protein-08 0.06 alanine dehydrogenase [EC:1.4.1.1]-08 0.05 leucyl-tRNA synthetase [EC:6.1.1.4]-30 0.02 formate dehydrogenase; alpha subunit [EC:1.2.1.2]-30 0.02 aconitate hydratase 1 [EC:4.2.1.3]-08 0.08 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide-08 0.08 modification methylase [EC:2.1.1.72]-08 0.02 magnesium transporter-08 0.06 argininosuccinate synthaseFor [EC:6.3.4.5]-08 Peer Review Only0.08 amino-acid N-acetyltransferase [EC:2.3.1.1]-08 0.03 alpha-glycerophosphate oxidase [EC:1.1.3.21]-08 0.02 pyruvate dehydrogenase E1 component [EC:1.2.4.1]-30 0.01 ATP-binding cassette; subfamily B; bacterial MsbA [EC:3.6.3.-]-08 0.04 phosphomannomutase [EC:5.4.2.8]-08 0.08 transcription-repair coupling factor (superfamily II helicase)-01 0.04 F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]-08 0.11 sulfate adenylyltransferase [EC:2.7.7.4]-08 0.05 rod shape-determining protein MreB and related proteins-08 0.06 GTP-binding protein LepA-30 0.01 diaminohydroxyphosphoribosylaminopyrimidine deaminase /-08 0.05 NADH dehydrogenase I subunit G [EC:1.6.5.3]-08 0.07 ATP-dependent Clp protease ATP-binding subunit ClpX-08 0.07 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]-08 0.04 phosphoribosylamine--glycine ligase [EC:6.3.4.13]-08 0.08 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP-30 0.01 succinate-semialdehyde dehydrogenase (NADP+) [EC:1.2.1.16]-08 0.07 fatty-acyl-CoA synthase [EC:6.2.1.-]-08 0.09 chromosomal replication initiator protein-08 0.07 glutamate N-acetyltransferase / amino-acid N-acetyltransferase-08 0.06 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]-30 0.01 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]-08 0.11 glucose inhibited division protein A-08 0.13 ATP-dependent Clp protease ATP-binding subunit ClpC-30 0.03 imidazolonepropionase [EC:3.5.2.7]-08 0.04 N utilization substance protein A-08 0.1 NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]-08 0.02 nucleoside-triphosphate pyrophosphatase [EC:3.6.1.19]-08 0.04 putative membrane protein-08 0.06 molecular chaperone DnaJ-08 0.08 alanine or glycine:cation symporter; AGCS family-08 0.06 nicotinate-nucleotide--dimethylbenzimidazole-08 0.03 ATP-dependent Clp protease; protease subunit [EC:3.4.21.92]-08 0.04 arginine N-succinyltransferase [EC:2.3.1.109]-08 0.02 cytochrome c oxidase subunit II [EC:1.9.3.1]-08 0.08 TldD protein-08 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 586 of 848

stearoyl-CoA desaturase (delta-9 desaturase) [EC:1.14.19.1]-08 0.01 ATP-dependent Clp protease ATP-binding subunit ClpA-08 0.07 ATP-dependent RNA helicase RhlB [EC:3.6.1.-]-08 0.03 translation initiation factor IF-2-01 0.07 dipeptide transport system permease protein-08 0.02 two-component system; NtrC family; nitrogen regulation response-08 0.06 primosomal protein N' (replication factor Y) (superfamily II-30 0.01 TetR/AcrR family transcriptional regulator-08 0.03 arginine decarboxylase [EC:4.1.1.19]-08 0.01 sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2]-08 0.03 DNA segregation ATPaseFor FtsK/SpoIIIE; Peer S-DNA-T family-30Review Only0.01 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit-08 0.08 alanyl-tRNA synthetase [EC:6.1.1.7]-08 0.12 phosphoglycerate mutase [EC:5.4.2.1]-08 0.09 penicillin-binding protein 2-08 0.09 oligopeptidase B [EC:3.4.21.83]-08 0.06 N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]-08 0.06 fructose-bisphosphate aldolase; class I [EC:4.1.2.13]-08 0.03 MFS transporter; DHA1 family; bicyclomycin/chloramphenicol-08 0.05 DNA ligase (ATP) [EC:6.5.1.1]-08 0.01 two-component system; NtrC family; nitrogen regulation sensor-08 0.07 thioredoxin reductase (NADPH) [EC:1.8.1.9]-08 0.08 solute:Na+ symporter; SSS family-08 0.05 aspartate aminotransferase [EC:2.6.1.1]-08 0.07 outer membrane protein-30 0.01 aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit B-08 0.06 magnesium chelatase family protein-08 0.04 prephenate dehydratase [EC:4.2.1.51]-08 0.06 ATP-dependent Clp protease ATP-binding subunit ClpC-08 0.04 putrescine transport system ATP-binding protein-08 0.03 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]-08 0.05 D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95]-08 0.09 glycine dehydrogenase [EC:1.4.4.2]-01 0.07 arginyl-tRNA synthetase [EC:6.1.1.19]-08 0.09 sulfoacetaldehyde acetyltransferase [EC:2.3.3.15]-08 0.03 long-chain acyl-CoA synthetase [EC:6.2.1.3]-30 0.01 pyruvate dehydrogenase E1 component [EC:1.2.4.1]-01 0.07 adenosylcobinamide-phosphate synthase CobD [EC:6.3.1.10]-08 0.03 histidinol dehydrogenase [EC:1.1.1.23]-01 0.07 LPS-assembly protein-08 0.05 molecular chaperone DnaK-01 0.06 DNA ligase (NAD+) [EC:6.5.1.2]-08 0.1 2;3;4;5-tetrahydropyridine-2-carboxylate N-succinyltransferase-08 0.05 magnesium and cobalt transporter-08 0.04 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase-08 0.05 ATP-dependent DNA helicase RecQ [EC:3.6.1.-]-30 0.02 tryptophan synthase beta chain [EC:4.2.1.20]-08 0.07

Wiley-Blackwell and Society for Applied Microbiology Page 587 of 848

preprotein translocase subunit YidC-08 0.08 argininosuccinate lyase [EC:4.3.2.1]-08 0.08 NADH dehydrogenase [EC:1.6.99.3]-08 0.05 cytochrome o ubiquinol oxidase subunit I [EC:1.10.3.-]-08 0.02 cysteine desulfurase [EC:2.8.1.7]-08 0.06 DNA ligase (NAD+) [EC:6.5.1.2]-30 0.01 phosphate starvation-inducible protein PhoH and related proteins-08 0.06 peptide/nickel transport system substrate-binding protein-30 0.01 acetylornithine deacetylase [EC:3.5.1.16]-08 0.04 PmbA protein-08 0.03 ATP-dependent DNAFor helicase RecG Peer [EC:3.6.1.-]-08 Review Only0.09 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]-08 0.05 bifunctional enzyme involved in thiolation and methylation of tRNA-30 0.01 F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]-08 0.1 general secretion pathway protein D-08 0.04 dihydrolipoamide dehydrogenase [EC:1.8.1.4]-08 0.1 methylthioribose-1-phosphate isomerase [EC:5.3.1.23]-08 0.01 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+)-30 0.01 IMP dehydrogenase [EC:1.1.1.205]-08 0.08 ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]-01 0.04 dimethylglycine dehydrogenase [EC:1.5.99.2]-30 0.01 UDP-N-acetylmuramoylalanyl-D-glutamate--2;6-diaminopimelate ligase-08 0.05 leucyl aminopeptidase [EC:3.4.11.1]-08 0.07 phosphoserine aminotransferase [EC:2.6.1.52]-08 0.05 biopolymer transport protein ExbB-08 0.04 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]-08 0.07 NADH dehydrogenase I subunit L [EC:1.6.5.3]-08 0.07 glucose inhibited division protein A-01 0.06 S-adenosylmethionine synthetase [EC:2.5.1.6]-30 0.01 peptidylprolyl isomerase [EC:5.2.1.8]-08 0.02 transketolase [EC:2.2.1.1]-01 0.06 phycobilisome core-membrane linker protein-08 0 phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]-08 0.08 Cu2+-exporting ATPase [EC:3.6.3.4]-08 0.04 adenosylhomocysteinase [EC:3.3.1.1]-30 0.01 S-adenosylmethionine synthetase [EC:2.5.1.6]-08 0.09 glucosamine--fructose-6-phosphate aminotransferase (isomerizing)-30 0.02 GDPmannose 4;6-dehydratase [EC:4.2.1.47]-08 0.05 ATP-dependent Lon protease [EC:3.4.21.53]-01 0.07 succinate dehydrogenase iron-sulfur protein [EC:1.3.99.1]-08 0.04 gamma-glutamyltranspeptidase [EC:2.3.2.2]-08 0.1 cytochrome c oxidase subunit I [EC:1.9.3.1]-01 0.07 peptidyl-dipeptidase Dcp [EC:3.4.15.5]-08 0.05 acetyl-CoA carboxylase carboxyl transferase subunit alpha-08 0.06 transcription termination factor Rho-30 0.01 polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]-01 0.07 acetylornithine/N-succinyldiaminopimelate aminotransferase-08 0.05

Wiley-Blackwell and Society for Applied Microbiology Page 588 of 848

RNA polymerase sigma-70 factor; ECF subfamily-08 0.04 hydrophobic/amphiphilic exporter-1 (mainly G- bacteria); HAE1 family-08 0.01 zinc transport system substrate-binding protein-08 0.04 ribonucleotide reductase; class II [EC:1.17.4.1]-08 0 DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.1.-]-01 0.06 carboxyl-terminal processing protease [EC:3.4.21.102]-30 0.01 3-isopropylmalate dehydrogenase [EC:1.1.1.85]-08 0.07 molybdopterin biosynthesis protein MoeA-08 0.06 dihydrolipoamide dehydrogenase [EC:1.8.1.4]-30 0.02 cell division protein FtsZ-30 0.01 5'-nucleotidase [EC:3.1.3.5]-08For Peer Review Only0.07 adenine deaminase [EC:3.5.4.2]-08 0.04 C4-dicarboxylate-binding protein DctP-08 0.02 CTP synthase [EC:6.3.4.2]-08 0.07 adenylosuccinate synthase [EC:6.3.4.4]-08 0.08 DNA replication and repair protein RecF-08 0.04 DNA polymerase III subunit gamma/tau [EC:2.7.7.7]-08 0.08 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)-08 0.05 molecular chaperone HtpG-30 0.02 adenosylcobyric acid synthase [EC:6.3.5.10]-08 0.04 leucyl aminopeptidase [EC:3.4.11.1]-30 0.01 histidinol-phosphate aminotransferase [EC:2.6.1.9]-08 0.07 polyphosphate kinase [EC:2.7.4.1]-08 0.03 thiamine-monophosphate kinase [EC:2.7.4.16]-08 0.04 methylmalonyl-CoA mutase [EC:5.4.99.2]-30 0.02 alanyl-tRNA synthetase [EC:6.1.1.7]-01 0.07 photosystem II PsbA protein-30 0.02 excinuclease ABC subunit B-08 0.11 dihydrofolate reductase [EC:1.5.1.3]-08 0.03 ATP-dependent RNA helicase RhlE [EC:3.6.1.-]-08 0.06 aminotransferase [EC:2.6.1.-]-08 0.05 DNA segregation ATPase FtsK/SpoIIIE; S-DNA-T family-01 0.06 GTP-binding protein LepA-01 0.05 D-amino-acid dehydrogenase [EC:1.4.99.1]-08 0.06 protein phosphatase 2 (formerly 2A); regulatory subunit B-30 0.02 ribosomal RNA small subunit methyltransferase B [EC:2.1.1.-]-08 0.05 alpha-mannosidase [EC:3.2.1.24]-08 0 DNA gyrase subunit A [EC:5.99.1.3]-01 0.07 1;4-alpha-glucan branching enzyme [EC:2.4.1.18]-08 0.02 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]-01 0.06 ubiquinone/menaquinone biosynthesis methyltransferase [EC:2.1.1.-]-08 0.05 methionyl-tRNA synthetase [EC:6.1.1.10]-08 0.09 cell division protease FtsH [EC:3.4.24.-]-01 0.05 proline iminopeptidase [EC:3.4.11.5]-08 0.04 bifunctional enzyme involved in thiolation and methylation of tRNA-08 0.08 seryl-tRNA synthetase [EC:6.1.1.11]-08 0.06 glutamate 5-kinase [EC:2.7.2.11]-08 0.06

Wiley-Blackwell and Society for Applied Microbiology Page 589 of 848

dihydroxy-acid dehydratase [EC:4.2.1.9]-01 0.06 ribonuclease E [EC:3.1.26.12]-08 0.06 isocitrate dehydrogenase kinase/phosphatase [EC:2.7.11.5 3.1.3.-]-08 0.02 5-oxoprolinase (ATP-hydrolysing) [EC:3.5.2.9]-08 0.04 ATP-dependent DNA helicase RecG [EC:3.6.1.-]-30 0.01 DNA recombination protein RmuC-08 0.05 lipoprotein-releasing system permease protein-08 0.06 molecular chaperone DnaK-30 0.03 taurine dioxygenase [EC:1.14.11.17]-08 0.04 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6)-08 0.05 acetyl-CoA synthetaseFor [EC:6.2.1.1]-01 Peer Review Only0.06 isocitrate dehydrogenase [EC:1.1.1.42]-08 0.09 ATP-dependent Clp protease ATP-binding subunit ClpX-30 0.01 inorganic pyrophosphatase [EC:3.6.1.1]-01 0.06 type I restriction enzyme; R subunit [EC:3.1.21.3]-30 0.01 succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]-08 0.06 queuine tRNA-ribosyltransferase [EC:2.4.2.29]-08 0.07 GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]-30 0.01 serine/threonine protein kinase; bacterial [EC:2.7.11.1]-08 0.01 periplasmic protein TorT-08 0.02 zinc transport system permease protein-08 0.03 phosphoglycolate phosphatase [EC:3.1.3.18]-08 0.05 aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit A-30 0.01 NADH dehydrogenase I subunit C/D [EC:1.6.5.3]-08 0.02 FdhD protein-08 0.04 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]-08 0.06 NAD(P) transhydrogenase subunit beta [EC:1.6.1.2]-30 0.01 putative ATPase-08 0.05 type IV pilus assembly protein PilB-08 0.02 putative glutathione S-transferase-08 0.04 aconitate hydratase 2 [EC:4.2.1.3]-01 0.03 branched-chain amino acid transport system ATP-binding protein-30 0.01 histidinol dehydrogenase [EC:1.1.1.23]-30 0.01 photosystem I core protein Ia-08 0.02 topoisomerase IV subunit B [EC:5.99.1.-]-30 0.01 ATP-dependent helicase HrpB [EC:3.6.1.-]-08 0.04 RNA polymerase sigma-32 factor-08 0.05 thiamine transport system substrate-binding protein-08 0.02 thiamine biosynthesis protein ThiC-08 0.01 glycogen operon protein GlgX [EC:3.2.1.-]-08 0 phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]-08 0.06 RNA polymerase primary sigma factor-01 0.05 dihydroorotase [EC:3.5.2.3]-08 0.1 beta-hexosaminidase [EC:3.2.1.52]-08 0.03 anthranilate synthase component I [EC:4.1.3.27]-08 0.07 exodeoxyribonuclease III [EC:3.1.11.2]-08 0.06 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+)-01 0.06

Wiley-Blackwell and Society for Applied Microbiology Page 590 of 848

threonyl-tRNA synthetase [EC:6.1.1.3]-30 0.02 molybdopterin oxidoreductase; molybdopterin binding subunit-08 0.03 GST-like protein-08 0.03 fumarate hydratase; class II [EC:4.2.1.2]-30 0.01 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1]-08 0.05 tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]-08 0.04 two-component system; OmpR family; osmolarity sensor histidine-08 0.02 DeoR family transcriptional regulator; glycerol-3-phosphate regulon-08 0.02 cysteine synthase A [EC:2.5.1.47]-08 0.04 chromosome segregation protein-01 0.05 phenylalanyl-tRNA synthetaseFor alphaPeer chain [EC:6.1.1.20]-08 Review Only0.06 2-isopropylmalate synthase [EC:2.3.3.13]-30 0.02 prolyl-tRNA synthetase [EC:6.1.1.15]-08 0.08 phosphoribosylanthranilate isomerase [EC:5.3.1.24]-08 0.03 pyridoxine 5-phosphate synthase [EC:2.6.99.2]-08 0.05 photosystem I core protein Ib-08 0.02 methylenetetrahydrofolate dehydrogenase (NADP+) /-08 0.06 two-component system; NtrC family; C4-dicarboxylate transport-08 0.02 phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]-01 0.06 simple sugar transport system ATP-binding protein [EC:3.6.3.17]-08 0.06 poly(A) polymerase [EC:2.7.7.19]-08 0.05 glutathione S-transferase [EC:2.5.1.18]-08 0.04 glycine amidinotransferase [EC:2.1.4.1]-08 0.02 phosphoglycerate mutase [EC:5.4.2.1]-30 0.01 chemotaxis protein MotB-08 0.04 ubiquinol-cytochrome c reductase cytochrome b subunit [EC:1.10.2.2]-30 0.01 DNA gyrase subunit B [EC:5.99.1.3]-01 0.07 2-octaprenyl-6-methoxyphenol hydroxylase [EC:1.14.13.-]-08 0.04 exodeoxyribonuclease I [EC:3.1.11.1]-08 0.03 integrase/recombinase XerC-08 0.03 phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]-30 0.02 glutamyl-tRNA synthetase [EC:6.1.1.17]-08 0.08 DNA repair protein RadA/Sms-08 0.06 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]-08 0.02 GTP-binding protein HflX-08 0.06 starch phosphorylase [EC:2.4.1.1]-08 0.01 3;4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]-30 0.01 glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]-08 0.03 pyruvate;orthophosphate dikinase [EC:2.7.9.1]-01 0.04 lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]-08 0.03 anthranilate synthase component II [EC:4.1.3.27]-08 0.04 ribonuclease R [EC:3.1.-.-]-30 0.01 N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.87]-08 0.03 D-cysteine desulfhydrase [EC:4.4.1.15]-08 0.02 DNA repair protein RadC-08 0.02 xanthine dehydrogenase large subunit [EC:1.17.1.4]-08 0.05 DNA topoisomerase II [EC:5.99.1.3]-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 591 of 848

DNA processing protein-08 0.03 isoquinoline 1-oxidoreductase; beta subunit [EC:1.3.99.16]-08 0.03 Cu2+-exporting ATPase [EC:3.6.3.4]-30 0.02 threonine dehydratase [EC:4.3.1.19]-30 0.01 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase /-30 0.01 thymidylate synthase (FAD) [EC:2.1.1.148]-01 0.03 excinuclease ABC subunit B-01 0.06 propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]-08 0.05 type I restriction enzyme M protein [EC:2.1.1.72]-30 0 DNA primase [EC:2.7.7.-]-08 0.08 glycerol-3-phosphateFor acyltransferase Peer PlsX [EC:2.3.1.15]-08 Review Only0.03 succinate dehydrogenase flavoprotein subunit [EC:1.3.99.1]-01 0.06 peptide/nickel transport system ATP-binding protein-01 0.03 penicillin-binding protein 2-30 0.01 pyruvate dehydrogenase E2 component (dihydrolipoamide-08 0.08 succinate-semialdehyde dehydrogenase (NADP+) [EC:1.2.1.16]-30 0.01 single-stranded-DNA-specific exonuclease [EC:3.1.-.-]-30 0.01 branched-chain amino acid transport system substrate-binding protein-30 0.01 F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]-01 0.05 aspartyl-tRNA synthetase [EC:6.1.1.12]-01 0.05 ribonuclease E [EC:3.1.26.12]-30 0.01 cell division protein FtsI (penicillin-binding protein 3)-30 0.01 recombination protein RecA-30 0.01 glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]-08 0.05 nucleobase:cation symporter-2; NCS2 family-08 0.03 serine--glyoxylate transaminase [EC:2.6.1.45]-08 0.03 5-methyltetrahydrofolate--homocysteine methyltransferase-30 0.02 exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]-08 0.02 putative iron-regulated protein-08 0.03 excinuclease ABC subunit B-30 0.01 peptide chain release factor RF-1-30 0.01 pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16-08 0.01 methionyl-tRNA synthetase [EC:6.1.1.10]-30 0.01 large subunit ribosomal protein L2-08 0.06 myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]-08 0.06 RNA polymerase primary sigma factor-30 0.01 NADPH2:quinone reductase [EC:1.6.5.5]-08 0.05 beta-galactosidase [EC:3.2.1.23]-08 0.05 glycine betaine/proline transport system permease protein-01 0.06 tryptophanyl-tRNA synthetase [EC:6.1.1.2]-08 0.06 phosphopantothenoylcysteine decarboxylase /-08 0.07 ribosome biogenesis GTPase [EC:3.6.1.-]-08 0.04 malate synthase [EC:2.3.3.9]-30 0.01 riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]-08 0.05 sarcosine oxidase; subunit beta [EC:1.5.3.1]-30 0.01 flagellar biosynthesis protein FlhA-08 0.04 malonyl-CoA decarboxylase [EC:4.1.1.9]-08 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 592 of 848

lipoic acid synthetase [EC:2.8.1.8]-08 0.06 serine protease SohB [EC:3.4.21.-]-08 0.02 X-Pro dipeptidase [EC:3.4.13.9]-08 0.03 NAD(P) transhydrogenase subunit alpha [EC:1.6.1.2]-08 0.07 adenylosuccinate synthase [EC:6.3.4.4]-30 0.01 topoisomerase IV subunit A [EC:5.99.1.-]-30 0.01 lysyl-tRNA synthetase; class I [EC:6.1.1.6]-08 0.03 xylose isomerase [EC:5.3.1.5]-08 0.02 cell division protein FtsZ-08 0.08 tRNA modification GTPase-08 0.08 tRNA(Ile)-lysidine synthaseFor [EC:6.3.4.-]-08 Peer Review Only0.05 DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]-08 0.07 aconitate hydratase 1 [EC:4.2.1.3]-01 0.05 antibiotic transport system ATP-binding protein-08 0.06 branched-chain amino acid aminotransferase [EC:2.6.1.42]-08 0.08 tRNA-dihydrouridine synthase A [EC:1.-.-.-]-08 0.04 xylulokinase [EC:2.7.1.17]-08 0.03 DNA-3-methyladenine glycosylase I [EC:3.2.2.20]-08 0.02 ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]-08 0.01 tryptophan synthase beta chain [EC:4.2.1.20]-30 0.01 dipeptidyl-peptidase 4 [EC:3.4.14.5]-08 0.03 phosphoribosylamine--glycine ligase [EC:6.3.4.13]-30 0.01 aspartate kinase [EC:2.7.2.4]-08 0.07 signal recognition particle subunit SRP54-30 0.01 HemY protein-08 0.03 tryptophan synthase alpha chain [EC:4.2.1.20]-08 0.04 phosphoenolpyruvate carboxylase [EC:4.1.1.31]-30 0 aspartate aminotransferase [EC:2.6.1.1]-30 0.01 preprotein translocase subunit SecY-30 0.01 holliday junction DNA helicase RuvB-08 0.05 photosystem II PsbD protein-30 0.02 glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]-30 0.01 phenylacetate-CoA ligase [EC:6.2.1.30]-08 0.03 dihydroorotase [EC:3.5.2.3]-01 0.06 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]-30 0.01 cobalamin biosynthetic protein CobC-08 0.02 phosphonoacetate hydrolase [EC:3.11.1.2]-08 0.02 uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase /-08 0.02 dihydroorotate oxidase [EC:1.3.3.1]-08 0.05 thioredoxin reductase (NADPH) [EC:1.8.1.9]-30 0.02 para-aminobenzoate synthetase component I [EC:2.6.1.85]-08 0.04 deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]-01 0.05 thioredoxin reductase (NADPH) [EC:1.8.1.9]-01 0.05 cysteinyl-tRNA synthetase [EC:6.1.1.16]-08 0.07 beta-glucosidase [EC:3.2.1.21]-08 0.03 preprotein translocase subunit SecF-08 0.05 penicillin-binding protein 1A [EC:2.4.1.- 3.4.-.-]-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 593 of 848

chromosome partitioning protein-30 0.01 monovalent cation:H+ antiporter-2; CPA2 family-08 0.03 NADH dehydrogenase I subunit N [EC:1.6.5.3]-08 0.05 penicillin-binding protein 1A [EC:2.4.1.- 3.4.-.-]-01 0.05 putative SAM-dependent methyltransferase-08 0.03 dGTPase [EC:3.1.5.1]-08 0.04 DnaJ like chaperone protein-08 0.03 thymidylate synthase (FAD) [EC:2.1.1.148]-30 0 UDPglucose 6-dehydrogenase [EC:1.1.1.22]-08 0.05 UDP-N-acetylmuramoylalanyl-D-glutamyl-2;6-diaminopimelate--D-alanyl--08 0.06 preprotein translocaseFor subunit SecD-08Peer Review Only0.07 N utilization substance protein A-30 0.01 geranylgeranyl reductase [EC:1.3.1.83]-08 0 flagellar M-ring protein FliF-08 0.02 acetyl-CoA carboxylase; biotin carboxylase subunit [EC:6.4.1.2-08 0.07 arabinose-5-phosphate isomerase [EC:5.3.1.13]-08 0.05 tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]-08 0.02 tRNA (guanine-N1-)-methyltransferase [EC:2.1.1.31]-08 0.05 DNA-directed RNA polymerase II subunit A [EC:2.7.7.6]-08 0.01 F-type H+-transporting ATPase subunit a [EC:3.6.3.14]-08 0.06 electron transport complex protein RnfD-08 0.02 NADH dehydrogenase I subunit H [EC:1.6.5.3]-08 0.04 glucosamine--fructose-6-phosphate aminotransferase (isomerizing)-01 0.05 valyl-tRNA synthetase [EC:6.1.1.9]-01 0.07 photosystem II PsbB protein-08 0.02 acetolactate synthase I/II/III large subunit [EC:2.2.1.6]-01 0.06 ketol-acid reductoisomerase [EC:1.1.1.86]-30 0.01 outer membrane protein-01 0.03 ATP-binding protein involved in chromosome partitioning-08 0.05 primosomal protein N' (replication factor Y) (superfamily II-01 0.05 S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:5.-.-.-]-08 0.05 acetyl-CoA carboxylase; biotin carboxylase subunit [EC:6.4.1.2-30 0.01 dihydrolipoamide dehydrogenase [EC:1.8.1.4]-01 0.05 UDP-N-acetylmuramoylalanyl-D-glutamyl-2;6-diaminopimelate--D-alanyl--30 0 small subunit ribosomal protein S1-30 0.01 pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]-08 0.03 methionine-gamma-lyase [EC:4.4.1.11]-08 0.02 tRNA-dihydrouridine synthase B [EC:1.-.-.-]-08 0.02 LAO/AO transport system kinase [EC:2.7.-.-]-08 0.03 iron(III) transport system ATP-binding protein [EC:3.6.3.30]-08 0.04 phosphopentomutase [EC:5.4.2.7]-08 0.03 acetylglutamate kinase [EC:2.7.2.8]-08 0.06 A/G-specific adenine glycosylase [EC:3.2.2.-]-08 0.05 F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]-01 0.05 oligopeptidase B [EC:3.4.21.83]-01 0.04 zinc transport system ATP-binding protein [EC:3.6.3.-]-08 0.03 Fe-S cluster assembly protein SufB-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 594 of 848

fused signal recognition particle receptor-30 0.02 gamma-glutamyltranspeptidase [EC:2.3.2.2]-01 0.02 Fe-S cluster assembly protein SufD-08 0.03 DNA ligase (NAD+) [EC:6.5.1.2]-01 0.05 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]-30 0.01 glycine C-acetyltransferase [EC:2.3.1.29]-08 0.03 bifunctional protein GlmU [EC:2.7.7.23 2.3.1.157]-08 0.06 RNA polymerase sigma-54 factor-08 0.05 cyclase HisF [EC:4.1.3.-]-08 0.05 tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]-08 0.04 cobaltochelatase CobTFor [EC:6.6.1.2]-01 Peer Review Only0.03 uracil-DNA glycosylase [EC:3.2.2.-]-08 0.02 small subunit ribosomal protein S1-01 0.05 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]-30 0.01 RNA polymerase nonessential primary-like sigma factor-08 0.02 dynein heavy chain; axonemal-08 0.01 2-dehydro-3-deoxyphosphogalactonate aldolase [EC:4.1.2.21]-08 0.02 iron(III) transport system permease protein-01 0.04 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P-08 0.02 polar amino acid transport system substrate-binding protein-08 0.03 ribose-phosphate pyrophosphokinase [EC:2.7.6.1]-08 0.06 branched-chain amino acid aminotransferase [EC:2.6.1.42]-30 0.01 exodeoxyribonuclease VII large subunit [EC:3.1.11.6]-08 0.05 alcohol dehydrogenase (acceptor) [EC:1.1.99.8]-08 0.02 dimethylglycine dehydrogenase [EC:1.5.99.2]-01 0.05 DNA polymerase V-08 0.02 signal peptidase I [EC:3.4.21.89]-08 0.04 histidyl-tRNA synthetase [EC:6.1.1.21]-08 0.07 F-type H+-transporting ATPase subunit gamma [EC:3.6.3.14]-08 0.06 sulfopyruvate decarboxylase subunit alpha [EC:4.1.1.79]-08 0.02 biopolymer transport protein ExbB-30 0 alanine or glycine:cation symporter; AGCS family-30 0 gamma-glutamylputrescine oxidase [EC:1.4.3.-]-08 0.03 TldD protein-30 0 pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]-08 0.04 urocanate hydratase [EC:4.2.1.49]-01 0.02 amidophosphoribosyltransferase [EC:2.4.2.14]-01 0.04 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate-08 0.03 photosystem II PsbC protein-30 0.03 topoisomerase IV subunit A [EC:5.99.1.-]-01 0.03 threonyl-tRNA synthetase [EC:6.1.1.3]-01 0.05 glycerol kinase [EC:2.7.1.30]-08 0.06 glutamyl-tRNA synthetase [EC:6.1.1.17]-30 0.01 protoheme IX farnesyltransferase [EC:2.5.1.-]-08 0.05 dihydrodipicolinate reductase [EC:1.3.1.26]-08 0.05 cell division protein FtsW-08 0.05 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]-08 0.06

Wiley-Blackwell and Society for Applied Microbiology Page 595 of 848

methyltransferase [EC:2.1.1.-]-08 0.03 trk system potassium uptake protein TrkH-30 0.01 pyruvate;orthophosphate dikinase [EC:2.7.9.1]-30 0.01 glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]-08 0.03 succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]-08 0.05 proline dehydrogenase / delta 1-pyrroline-5-carboxylate-01 0.02 small subunit ribosomal protein S3-08 0.05 ribosomal large subunit pseudouridine synthase E [EC:5.4.99.12]-08 0.02 phosphoglucosamine mutase [EC:5.4.2.10]-08 0.06 trigger factor-08 0.07 X-Pro aminopeptidaseFor [EC:3.4.11.9]-30 Peer Review Only0.01 type I restriction enzyme; R subunit [EC:3.1.21.3]-08 0.04 ribose-phosphate pyrophosphokinase [EC:2.7.6.1]-30 0.01 regulator of sigma E protease [EC:3.4.24.-]-08 0.05 3D-(3;5/4)-trihydroxycyclohexane-1;2-dione hydrolase [EC:3.7.1.-]-08 0.03 ATP-dependent helicase Lhr and Lhr-like helicase [EC:3.6.1.-]-30 0.01 acetyl-CoA carboxylase / biotin carboxylase [EC:6.4.1.2 6.3.4.14]-30 0.02 phenylalanine-4-hydroxylase [EC:1.14.16.1]-08 0.02 protochlorophyllide reductase [EC:1.3.1.33]-08 0 glutamate-ammonia-ligase adenylyltransferase [EC:2.7.7.42]-30 0 anthranilate phosphoribosyltransferase [EC:2.4.2.18]-08 0.05 bifunctional protein GlmU [EC:2.7.7.23 2.3.1.157]-30 0.01 phosphorylase kinase alpha/beta subunit-08 0 rod shape determining protein RodA-08 0.06 putative tricarboxylic transport membrane protein-08 0.04 enolase [EC:4.2.1.11]-30 0.01 succinylarginine dihydrolase [EC:3.5.3.23]-08 0.02 dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12-08 0.04 phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]-30 0.01 DNA polymerase III subunit gamma/tau [EC:2.7.7.7]-30 0.01 phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]-08 0.05 carnitinyl-CoA dehydratase [EC:4.2.1.-]-08 0.02 succinyl-CoA synthetase beta subunit [EC:6.2.1.5]-08 0.07 mevalonate kinase [EC:2.7.1.36]-08 0.02 acetyl-CoA carboxylase carboxyl transferase subunit beta-08 0.05 LysR family transcriptional regulator; hydrogen peroxide-inducible-08 0.02 putative spermidine/putrescine transport system substrate-binding-08 0.04 CTP synthase [EC:6.3.4.2]-30 0.01 6-phosphogluconate dehydrogenase [EC:1.1.1.44]-08 0.04 chorismate synthase [EC:4.2.3.5]-08 0.07 diaminopropionate ammonia-lyase [EC:4.3.1.15]-08 0.03 ubiquinol-cytochrome c reductase cytochrome c1 subunit [EC:1.10.2.2]-08 0.03 phosphate acetyltransferase [EC:2.3.1.8]-08 0.03 magnesium transporter-30 0.01 lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]-08 0.05 two-component system; NtrC family; nitrogen regulation response-30 0.01 IclR family transcriptional regulator; acetate operon repressor-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 596 of 848

ammonium transporter; Amt family-08 0.04 ribosomal large subunit pseudouridine synthase D [EC:5.4.99.12]-08 0.05 sulfonate/nitrate/taurine transport system substrate-binding protein-08 0.05 sarcosine oxidase; subunit gamma [EC:1.5.3.1]-08 0.03 RIO kinase 1 [EC:2.7.11.1]-08 0.02 trimethylamine-N-oxide reductase (cytochrome c) 2 [EC:1.7.2.3]-08 0.03 malate dehydrogenase [EC:1.1.1.37]-08 0.06 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP-01 0.04 GntR family transcriptional regulator; transcriptional repressor for-08 0.02 cytochrome c oxidase subunit III [EC:1.9.3.1]-08 0.06 DNA (cytosine-5-)-methyltransferaseFor Peer [EC:2.1.1.37]-08 Review Only0.02 5'-nucleotidase [EC:3.1.3.5]-30 0.01 fused signal recognition particle receptor-08 0.06 multicomponent Na+:H+ antiporter subunit B-08 0.02 quinoprotein glucose dehydrogenase [EC:1.1.5.2]-08 0.01 2-methylcitrate dehydratase [EC:4.2.1.79]-08 0.01 6-phosphofructokinase [EC:2.7.1.11]-08 0.03 nucleoside-triphosphatase [EC:3.6.1.15]-08 0.04 cobaltochelatase CobS [EC:6.6.1.2]-08 0.02 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]-08 0.03 3;4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]-08 0.07 polyphosphate kinase [EC:2.7.4.1]-30 0 putative translation factor-08 0.05 hydroxymethylbilane synthase [EC:2.5.1.61]-08 0.05 twitching motility protein PilT-08 0.01 putative MFS transporter; AGZA family; xanthine/uracil permease-08 0.02 carbon-monoxide dehydrogenase large subunit [EC:1.2.99.2]-08 0.03 N utilization substance protein A-01 0.05 MoxR-like ATPase [EC:3.6.3.-]-08 0.05 LysR family transcriptional regulator; glycine cleavage system-08 0.02 electron transfer flavoprotein alpha subunit-08 0.04 electron transport complex protein RnfB-08 0.02 oligoendopeptidase F [EC:3.4.24.-]-08 0.02 regulator of sigma E protease [EC:3.4.24.-]-30 0.01 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]-01 0.04 starch synthase [EC:2.4.1.21]-08 0.02 carbamoyltransferase [EC:2.1.3.-]-08 0.02 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]-01 0.05 NADH dehydrogenase I subunit F [EC:1.6.5.3]-30 0.01 arylsulfatase [EC:3.1.6.1]-08 0.01 aspartyl-tRNA synthetase [EC:6.1.1.12]-30 0.01 elongation factor EF-Tu [EC:3.6.5.3]-30 0.03 pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]-08 0.03 Na+-transporting NADH:ubiquinone oxidoreductase subunit B-08 0.03 membrane protease subunit HflC [EC:3.4.-.-]-08 0.04 threonine 3-dehydrogenase [EC:1.1.1.103]-08 0.02 biotin synthetase [EC:2.8.1.6]-08 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 597 of 848

MFS transporter; PAT family; beta-lactamase induction signal-08 0.03 soluble lytic murein transglycosylase [EC:3.2.1.-]-30 0.01 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]-30 0.02 tRNA pseudouridine synthase B [EC:5.4.99.12]-08 0.04 prolyl-tRNA synthetase [EC:6.1.1.15]-30 0.01 agmatinase [EC:3.5.3.11]-30 0.01 ferredoxin-08 0.03 ferrochelatase [EC:4.99.1.1]-08 0.06 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]-30 0.01 rubredoxin-NAD+ reductase [EC:1.18.1.1]-08 0.02 phosphatidylserine synthaseFor [EC:2.7.8.8]-08 Peer Review Only0.03 nicotinate phosphoribosyltransferase [EC:2.4.2.11]-08 0.02 ribonuclease D [EC:3.1.13.5]-08 0.04 outer membrane channel protein TolC-08 0.04 DNA primase [EC:2.7.7.-]-01 0.05 threonine synthase [EC:4.2.3.1]-30 0.01 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide-30 0.01 UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]-30 0.01 general L-amino acid transport system permease protein-01 0.04 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide-08 0.04 ornithine decarboxylase [EC:4.1.1.17]-08 0.02 excinuclease ABC subunit C-01 0.05 DNA recombination protein RmuC-30 0 chorismate synthase [EC:4.2.3.5]-30 0.01 phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]-30 0 methionyl-tRNA formyltransferase [EC:2.1.2.9]-08 0.05 dihydrodipicolinate synthase [EC:4.2.1.52]-30 0.01 DNA polymerase III subunit beta [EC:2.7.7.7]-30 0 protein-L-isoaspartate(D-aspartate) O-methyltransferase-08 0.04 fructose-1;6-bisphosphatase II [EC:3.1.3.11]-08 0.01 recombination protein RecA-08 0.05 cysteine synthase A [EC:2.5.1.47]-30 0.01 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]-30 0.01 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]-08 0.04 queuine tRNA-ribosyltransferase [EC:2.4.2.29]-30 0.01 TolB protein-08 0.04 Na+-transporting NADH:ubiquinone oxidoreductase subunit A-08 0.03 general L-amino acid transport system substrate-binding protein-08 0.04 ATP-dependent DNA helicase RecG [EC:3.6.1.-]-01 0.05 uroporphyrinogen decarboxylase [EC:4.1.1.37]-08 0.06 SecD/SecF fusion protein-08 0.04 phosphoglycerate kinase [EC:2.7.2.3]-30 0.01 TdcF protein-08 0.02 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase-08 0.06 fructose-1;6-bisphosphatase I [EC:3.1.3.11]-08 0.02 elongation factor EF-Tu [EC:3.6.5.3]-01 0.03 phosphatidylserine decarboxylase [EC:4.1.1.65]-08 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 598 of 848

BirA family transcriptional regulator; biotin operon repressor /-08 0.03 7;8-dihydro-8-oxoguanine triphosphatase [EC:3.6.1.-]-08 0.02 IMP dehydrogenase [EC:1.1.1.205]-30 0.01 DNA-directed RNA polymerase II subunit A [EC:2.7.7.6]-30 0.01 light-independent protochlorophyllide reductase subunit B-08 0 putative transcriptional regulator-08 0.04 diaminopimelate decarboxylase [EC:4.1.1.20]-08 0.06 penicillin-binding protein 2-01 0.05 aminopeptidase N [EC:3.4.11.2]-08 0.07 4-hydroxyphenylacetate-3-hydroxylase large chain [EC:1.14.13.3]-08 0.01 anhydro-N-acetylmuramicFor acid kinasePeer [EC:2.7.1.-]-08 Review Only0.03 putative glutamine amidotransferase-08 0.02 protease IV [EC:3.4.21.-]-08 0.03 ATP-binding cassette; sub-family F; member 3-30 0.01 adenosylhomocysteinase [EC:3.3.1.1]-08 0.1 photosystem II PsbC protein-08 0.02 GTP cyclohydrolase I [EC:3.5.4.16]-08 0.04 nicotinate-nucleotide pyrophosphorylase (carboxylating)-08 0.03 DNA polymerase III subunit gamma/tau [EC:2.7.7.7]-01 0.04 ornithine cyclodeaminase [EC:4.3.1.12]-08 0.03 pyruvate carboxylase [EC:6.4.1.1]-30 0.02 magnesium chelatase subunit D [EC:6.6.1.1]-08 0.01 MFS transporter; FHS family; L-fucose permease-08 0.02 GntR family transcriptional regulator; histidine utilization-08 0.02 shikimate dehydrogenase [EC:1.1.1.25]-08 0.04 cytochrome c-type biogenesis protein CcmH-08 0.03 D-alanine-D-alanine ligase [EC:6.3.2.4]-08 0.04 cytidylate kinase [EC:2.7.4.14]-08 0.04 dolichyl-diphosphooligosaccharide--protein glycosyltransferase-08 0.01 peptide/nickel transport system permease protein-01 0.02 small subunit ribosomal protein S7-08 0.03 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase-08 0.06 O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]-01 0.04 DNA (cytosine-5-)-methyltransferase [EC:2.1.1.37]-30 0.01 aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]-08 0.06 Lrp/AsnC family transcriptional regulator; leucine-responsive-08 0.02 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]-08 0.05 alkanesulfonate monooxygenase [EC:1.14.14.5]-08 0.03 [protein-PII] uridylyltransferase [EC:2.7.7.59]-30 0.01 transcriptional antiterminator NusG-08 0.04 adenylate kinase [EC:2.7.4.3]-08 0.04 citrate synthase [EC:2.3.3.1]-30 0.01 peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]-08 0.04 UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]-08 0.08 transitional endoplasmic reticulum ATPase-08 0.01 NADH dehydrogenase [EC:1.6.99.3]-30 0.01 catalase/peroxidase [EC:1.11.1.6 1.11.1.7]-01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 599 of 848

2-dehydro-3-deoxygalactonokinase [EC:2.7.1.58]-08 0.02 L-lactate dehydrogenase (cytochrome) [EC:1.1.2.3]-30 0.01 cobalamin biosynthesis protein CbiG / precorrin-3B-08 0.02 quinolinate synthase [EC:2.5.1.72]-08 0.04 preprotein translocase subunit SecY-01 0.04 electron transport complex protein RnfE-08 0.01 beta-N-acetylhexosaminidase [EC:3.2.1.52]-08 0.02 enoyl-CoA hydratase [EC:4.2.1.17]-30 0.02 NAD(P) transhydrogenase subunit alpha [EC:1.6.1.2]-30 0.01 carboxyl-terminal processing protease [EC:3.4.21.102]-01 0.04 S-formylglutathioneFor hydrolase [EC:3.1.2.12]-08Peer Review Only0.03 pyruvate kinase [EC:2.7.1.40]-08 0.06 cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]-01 0.04 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase-08 0.03 pre-mRNA-processing factor 8-08 0 acyl-CoA thioesterase I [EC:3.1.2.- 3.1.1.5]-08 0.02 adenosylmethionine-8-amino-7-oxononanoate aminotransferase-08 0.02 5-methyltetrahydrofolate--homocysteine methyltransferase-01 0.02 3-dehydroquinate synthase [EC:4.2.3.4]-08 0.05 chromosomal replication initiator protein-01 0.04 ketol-acid reductoisomerase [EC:1.1.1.86]-08 0.07 general secretion pathway protein E-08 0.03 glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]-08 0.06 homoserine O-acetyltransferase [EC:2.3.1.31]-08 0.03 ammonium transporter; Amt family-30 0.01 NAD+ kinase [EC:2.7.1.23]-08 0.04 small subunit ribosomal protein S2-08 0.05 preprotein translocase subunit YidC-30 0.01 tRNA modification GTPase-01 0.04 methionyl-tRNA formyltransferase [EC:2.1.2.9]-30 0.01 replicative DNA helicase [EC:3.6.1.-]-30 0.01 methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.27]-01 0.04 ABC-2 type transport system permease protein-08 0.03 O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]-30 0.01 ribosomal large subunit pseudouridine synthase D [EC:5.4.99.12]-30 0.01 iron(III) transport system permease protein-30 0.01 ribonuclease R [EC:3.1.-.-]-01 0.03 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]-08 0.06 fumarate hydratase; class II [EC:4.2.1.2]-01 0.03 heat-inducible transcriptional repressor-08 0.02 formate dehydrogenase; alpha subunit [EC:1.2.1.2]-01 0.06 D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95]-30 0.01 guanosine-3';5'-bis(diphosphate) 3'-pyrophosphohydrolase-08 0.03 branched-chain amino acid transport system ATP-binding protein-01 0.04 DNA-directed RNA polymerase II subunit B [EC:2.7.7.6]-08 0.01 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]-01 0.04 leucyl aminopeptidase [EC:3.4.11.1]-01 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 600 of 848

cytochrome c-type biogenesis protein CcmF-30 0.01 sodium/proline symporter-08 0.02 ATP-dependent RNA helicase DeaD-30 0.01 MoxR-like ATPase [EC:3.6.3.-]-30 0.01 ATP-dependent Clp protease ATP-binding subunit ClpB-30 0.01 CTP synthase [EC:6.3.4.2]-01 0.04 riboflavin synthase alpha chain [EC:2.5.1.9]-08 0.04 glutamate-1-semialdehyde 2;1-aminomutase [EC:5.4.3.8]-30 0.01 3-demethylubiquinone-9 3-methyltransferase [EC:2.1.1.- 2.1.1.64]-08 0.04 PTS system; nitrogen regulatory IIA component [EC:2.7.1.69]-08 0.02 homoserine O-acetyltransferaseFor Peer[EC:2.3.1.31]-01 Review Only0.03 NADH dehydrogenase I subunit B [EC:1.6.5.3]-08 0.03 glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]-01 0.05 anthranilate synthase component I [EC:4.1.3.27]-01 0.04 argininosuccinate lyase [EC:4.3.2.1]-30 0.01 cytochrome c-type biogenesis protein CcmF-01 0.04 galactarate dehydratase [EC:4.2.1.42]-08 0.02 arginyl-tRNA synthetase [EC:6.1.1.19]-01 0.04 adenylosuccinate lyase [EC:4.3.2.2]-08 0.06 ATP-binding cassette; subfamily B; bacterial-01 0.02 glycyl-tRNA synthetase beta chain [EC:6.1.1.14]-30 0.01 2-oxoglutarate ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3]-08 0.01 large subunit ribosomal protein L13-08 0.03 general L-amino acid transport system ATP-binding protein-08 0.03 neurotransmitter:Na+ symporter; NSS family-30 0 molecular chaperone DnaJ-30 0.01 flagellar motor switch protein FliG-08 0.02 adenosylhomocysteinase [EC:3.3.1.1]-01 0.04 dTDP-glucose 4;6-dehydratase [EC:4.2.1.46]-08 0.04 UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]-08 0.04 replicative DNA helicase [EC:3.6.1.-]-01 0.04 2-haloacid dehalogenase [EC:3.8.1.2]-08 0.02 NAD+ synthase [EC:6.3.1.5]-08 0.03 cytochrome c oxidase subunit II [EC:1.9.3.1]-30 0.01 glutathione synthase [EC:6.3.2.3]-08 0.04 choline dehydrogenase [EC:1.1.99.1]-30 0.01 ATP-dependent Clp protease; protease subunit [EC:3.4.21.92]-30 0.01 large subunit ribosomal protein L9-08 0.03 phosphate transport system permease protein-30 0 DNA primase [EC:2.7.7.-]-30 0.01 two-component system; chemotaxis family; sensor kinase CheA-08 0.01 oligoribonuclease [EC:3.1.-.-]-08 0.02 signal recognition particle subunit SRP54-01 0.04 RNA methyltransferase; TrmH family [EC:2.1.1.-]-08 0.04 Na+-transporting NADH:ubiquinone oxidoreductase subunit F-08 0.04 lysyl-tRNA synthetase; class II [EC:6.1.1.6]-01 0.02 glycyl-tRNA synthetase [EC:6.1.1.14]-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 601 of 848

peptide chain release factor RF-3-30 0.01 aminopeptidase N [EC:3.4.11.2]-01 0.02 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1]-30 0.01 LysR family transcriptional regulator; positive regulator for ilvC-08 0.02 multiple sugar transport system permease protein-30 0.01 chromosome partitioning protein-08 0.06 membrane protease subunit HflK [EC:3.4.-.-]-08 0.05 O-sialoglycoprotein endopeptidase [EC:3.4.24.57]-08 0.06 Fe-S cluster assembly protein SufD-30 0 dynein heavy chain; axonemal-30 0.01 acetyl-CoA carboxylaseFor biotin carboxyl Peer carrier protein-08 Review Only0.03 cob(I)alamin adenosyltransferase [EC:2.5.1.17]-08 0.03 GMP reductase [EC:1.7.1.7]-08 0 precorrin-3B C17-methyltransferase [EC:2.1.1.131]-08 0.02 isocitrate dehydrogenase [EC:1.1.1.42]-01 0.04 carboxypeptidase Taq [EC:3.4.17.19]-08 0.01 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) [EC:3.6.1.41]-08 0.02 phosphoserine phosphatase [EC:3.1.3.3]-08 0.03 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]-30 0.01 dynein heavy chain 1; cytosolic-30 0.02 phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]-01 0.02 beta-glucosidase [EC:3.2.1.21]-30 0.01 threonine synthase [EC:4.2.3.1]-01 0.04 recombination protein RecA-01 0.04 DNA polymerase III subunit epsilon [EC:2.7.7.7]-30 0.01 aspartate kinase [EC:2.7.2.4]-30 0.01 hippurate hydrolase [EC:3.5.1.32]-30 0.01 LysR family transcriptional regulator; cys regulon transcriptional-08 0.02 citrate synthase [EC:2.3.3.1]-08 0.06 polar amino acid transport system permease protein-08 0.03 hydroxypyruvate isomerase [EC:5.3.1.22]-08 0.02 multiple sugar transport system substrate-binding protein-30 0.01 tryptophanyl-tRNA synthetase [EC:6.1.1.2]-30 0.01 molybdate transport system ATP-binding protein-08 0.01 AraC family transcriptional regulator; regulatory protein of-08 0.01 rod shape-determining protein MreB and related proteins-30 0.01 [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]-08 0.04 A biosynthesis lauroyl acyltransferase [EC:2.3.1.-]-08 0.04 superoxide dismutase; Fe-Mn family [EC:1.15.1.1]-08 0.01 serine O-acetyltransferase [EC:2.3.1.30]-08 0.04 ATP-dependent RNA helicase RhlE [EC:3.6.1.-]-30 0.01 thiamine transport system permease protein-08 0.02 sec-independent protein translocase protein TatC-08 0.04 tRNA 2-selenouridine synthase [EC:2.9.1.-]-08 0.03 cytochrome c oxidase subunit III [EC:1.9.3.1]-01 0.04 ABC-2 type transport system ATP-binding protein-08 0.02 branched-chain amino acid transport system substrate-binding protein-01 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 602 of 848

coniferyl-aldehyde dehydrogenase [EC:1.2.1.68]-08 0.03 ATP-dependent Clp protease ATP-binding subunit ClpA-30 0.01 oxygen-independent coproporphyrinogen III oxidase [EC:1.3.99.22]-30 0.01 NADH dehydrogenase I subunit L [EC:1.6.5.3]-01 0.04 peptide/nickel transport system substrate-binding protein-01 0.02 virulence factor-01 0.03 proline dehydrogenase / delta 1-pyrroline-5-carboxylate-30 0.01 pyruvate dehydrogenase E2 component (dihydrolipoamide-30 0.02 urease accessory protein-08 0.01 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [EC:1.17.1.2]-08 0.04 tRNA modification GTPase-30For Peer Review Only0.01 peptide chain release factor RF-2-08 0.05 F-type H+-transporting ATPase subunit epsilon [EC:3.6.3.14]-08 0.03 ferredoxin-30 0 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide-01 0.04 electron-transferring-flavoprotein dehydrogenase [EC:1.5.5.1]-30 0.01 methionyl aminopeptidase [EC:3.4.11.18]-08 0.05 molybdenum cofactor biosynthesis protein A-08 0.04 small subunit ribosomal protein S14-08 0.03 ribosomal large subunit pseudouridine synthase A [EC:5.4.99.12]-08 0.02 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6)-30 0 disulfide bond formation protein DsbB-08 0.02 sirohydrochlorin cobaltochelatase [EC:4.99.1.3]-08 0.01 dTDP-glucose 4;6-dehydratase [EC:4.2.1.46]-30 0.01 cysteine desulfurase [EC:2.8.1.7]-30 0.01 N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]-08 0.04 myo-inositol 2-dehydrogenase [EC:1.1.1.18]-08 0.02 type I restriction enzyme M protein [EC:2.1.1.72]-08 0.03 malate synthase [EC:2.3.3.9]-01 0.05 TldD protein-01 0.03 malate dehydrogenase [EC:1.1.1.37]-30 0.01 putative ATP-binding cassette transporter-08 0 phytoene dehydrogenase; phytoene desaturase [EC:1.14.99.-]-08 0 sulfate permease; SulP family-08 0.01 diacylglycerol kinase [EC:2.7.1.107]-08 0.02 capsular polysaccharide export protein-08 0.01 tRNA dimethylallyltransferase [EC:2.5.1.75]-08 0.04 phosphoglycerate kinase [EC:2.7.2.3]-08 0.07 glycine hydroxymethyltransferase [EC:2.1.2.1]-30 0.02 riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]-30 0 UDP-N-acetylmuramate dehydrogenase [EC:1.1.1.158]-08 0.04 salicylate hydroxylase [EC:1.14.13.1]-08 0.01 2-hydroxy-3-oxopropionate reductase [EC:1.1.1.60]-08 0.02 NADH dehydrogenase I subunit F [EC:1.6.5.3]-01 0.04 preprotein translocase subunit YidC-01 0.04 phosphonate transport system permease protein-08 0.03 myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 603 of 848

ATP phosphoribosyltransferase [EC:2.4.2.17]-08 0.04 N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]-08 0.02 NADH dehydrogenase I subunit M [EC:1.6.5.3]-01 0.03 antibiotic transport system ATP-binding protein-30 0.01 general L-amino acid transport system permease protein-30 0.01 sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]-08 0.02 Fe-S cluster assembly protein SufB-01 0.03 glycine betaine/proline transport system substrate-binding protein-01 0.04 MFS transporter; PAT family; beta-lactamase induction signal-01 0.03 glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]-30 0.01 gamma-butyrobetaineFor dioxygenase Peer [EC:1.14.11.1]-08 Review Only0.02 mannose-6-phosphate isomerase [EC:5.3.1.8]-08 0.02 phosphoribosylaminoimidazole-succinocarboxamide synthase-08 0.05 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]-30 0.01 acetylornithine aminotransferase [EC:2.6.1.11]-08 0.02 putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]-08 0.03 magnesium chelatase subunit I [EC:6.6.1.1]-08 0.01 phenylacetic acid degradation protein-30 0.01 small subunit ribosomal protein S4-08 0.05 heme exporter protein C-08 0.03 methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.27]-30 0.01 histidine transport system permease protein-08 0.01 putative spermidine/putrescine transport system permease protein-08 0.04 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [EC:1.2.1.-]-08 0.02 cysteinyl-tRNA synthetase [EC:6.1.1.16]-01 0.04 2-aminoethylphosphonate-pyruvate transaminase [EC:2.6.1.37]-08 0.01 cysteinyl-tRNA synthetase [EC:6.1.1.16]-30 0.01 deoxyhypusine synthase [EC:2.5.1.46]-08 0.01 MSHA biogenesis protein MshL-08 0.01 amidase [EC:3.5.1.4]-08 0.03 NADH dehydrogenase I subunit I [EC:1.6.5.3]-08 0.02 N-acetylneuraminate synthase [EC:2.5.1.56]-08 0.04 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1]-01 0.03 integrase/recombinase XerD-08 0.03 dihydrodipicolinate synthase [EC:4.2.1.52]-01 0.04 apolipoprotein N-acyltransferase [EC:2.3.1.-]-08 0.05 lysyl-tRNA synthetase; class I [EC:6.1.1.6]-01 0.02 peroxiredoxin (alkyl hydroperoxide reductase subunit C)-08 0.02 electron transfer flavoprotein beta subunit-08 0.04 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]-30 0.01 xanthine dehydrogenase small subunit [EC:1.17.1.4]-08 0.03 acetyl-CoA C-acetyltransferase [EC:2.3.1.9]-01 0.04 trigger factor-30 0.01 UDPglucose 6-dehydrogenase [EC:1.1.1.22]-30 0.01 cytochrome c oxidase subunit II [EC:1.9.3.1]-01 0.04 adenylosuccinate lyase [EC:4.3.2.2]-01 0.03 erythritol kinase [EC:2.7.1.27]-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 604 of 848

Na+-transporting NADH:ubiquinone oxidoreductase subunit C-08 0.02 thiosulfate sulfurtransferase [EC:2.8.1.1]-08 0.02 NAD-dependent deacetylase [EC:3.5.1.-]-08 0.01 peptide chain release factor RF-2-30 0 adenylosuccinate synthase [EC:6.3.4.4]-01 0.03 MFS transporter; NNP family; nitrate/nitrite transporter-08 0 putative ABC transport system ATP-binding protein-08 0.03 propionyl-CoA synthetase [EC:6.2.1.17]-01 0.03 magnesium transporter-01 0.03 arginine-tRNA-protein transferase [EC:2.3.2.8]-08 0.02 thiamine biosynthesisFor lipoprotein-08 Peer Review Only0.02 aminopeptidase N [EC:3.4.11.2]-30 0.01 AMP nucleosidase [EC:3.2.2.4]-08 0.02 chromosome partitioning protein; ParB family-30 0.01 bifunctional enzyme CysN/CysC [EC:2.7.7.4 2.7.1.25]-08 0.02 cytochrome c oxidase subunit XV assembly protein-08 0.04 large subunit ribosomal protein L11-08 0.03 orotate phosphoribosyltransferase [EC:2.4.2.10]-08 0.03 soluble lytic murein transglycosylase [EC:3.2.1.-]-01 0.03 X-Pro aminopeptidase [EC:3.4.11.9]-01 0.04 GTP-binding protein HflX-30 0.01 apocytochrome f-30 0.01 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit-08 0.03 pyrroline-5-carboxylate reductase [EC:1.5.1.2]-08 0.04 seryl-tRNA synthetase [EC:6.1.1.11]-01 0.03 guanine deaminase [EC:3.5.4.3]-08 0.02 tryptophan synthase beta chain [EC:4.2.1.20]-01 0.03 peptide chain release factor RF-3-01 0.02 phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19]-08 0.02 glycyl-tRNA synthetase beta chain [EC:6.1.1.14]-01 0.04 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit-01 0.04 alcohol dehydrogenase [EC:1.1.1.1]-30 0.01 hydroxyatrazine ethylaminohydrolase [EC:3.5.99.3]-08 0.02 formate--tetrahydrofolate ligase [EC:6.3.4.3]-30 0.01 molybdenum cofactor biosynthesis protein B-08 0.02 ATP-dependent Clp protease ATP-binding subunit ClpX-01 0.04 aspartate racemase [EC:5.1.1.13]-08 0.02 transcription termination factor Rho-01 0.04 DNA-binding protein HU-beta-08 0.03 glucosamine-6-phosphate deaminase [EC:3.5.99.6]-08 0.01 adenine phosphoribosyltransferase [EC:2.4.2.7]-08 0.02 sucrose phosphorylase [EC:2.4.1.7]-08 0 methyl-accepting chemotaxis protein-08 0.01 aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]-30 0 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]-08 0.02 formate dehydrogenase [EC:1.2.1.2]-08 0.02 histidyl-tRNA synthetase [EC:6.1.1.21]-01 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 605 of 848

MSHA biogenesis protein MshE-08 0.01 ribulose-phosphate 3-epimerase [EC:5.1.3.1]-08 0.04 sn-glycerol 3-phosphate transport system ATP-binding protein-08 0.02 topoisomerase IV subunit B [EC:5.99.1.-]-01 0.03 ATP-binding protein involved in chromosome partitioning-30 0.01 aspartyl aminopeptidase [EC:3.4.11.21]-08 0.01 DNA repair protein RecN (Recombination protein N)-01 0.02 GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]-01 0.04 protein phosphatase 2 (formerly 2A); regulatory subunit B-08 0.01 acetyl-CoA carboxylase; biotin carboxylase subunit [EC:6.4.1.2-01 0.04 E1A/CREB-binding proteinFor [EC:2.3.1.48]-30 Peer Review Only0.02 acetyl-CoA carboxylase / biotin carboxylase [EC:6.4.1.2 6.3.4.14]-08 0 adenylosuccinate lyase [EC:4.3.2.2]-30 0.01 peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]-30 0 phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]-30 0 UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]-08 0.03 preprotein translocase subunit SecD-30 0.01 magnesium chelatase subunit H [EC:6.6.1.1]-30 0.02 beta-alanine--pyruvate transaminase [EC:2.6.1.18]-08 0.04 4-hydroxybenzoate octaprenyltransferase [EC:2.5.1.-]-08 0.04 glutamyl-tRNA synthetase [EC:6.1.1.17]-01 0.04 F-type H+-transporting ATPase subunit gamma [EC:3.6.3.14]-30 0.01 DNA polymerase bacteriophage-type [EC:2.7.7.7]-08 0.02 NAD+ kinase [EC:2.7.1.23]-30 0 orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]-08 0.04 formate--tetrahydrofolate ligase [EC:6.3.4.3]-01 0.04 prephenate dehydratase [EC:4.2.1.51]-30 0.01 D-threo-aldose 1-dehydrogenase [EC:1.1.1.122]-08 0.01 MFS transporter; UMF1 family-08 0.02 Lrp/AsnC family transcriptional regulator-08 0.02 NADH dehydrogenase I subunit L [EC:1.6.5.3]-30 0.01 recombination protein RecR-08 0.03 formyltetrahydrofolate deformylase [EC:3.5.1.10]-08 0.01 neurotransmitter:Na+ symporter; NSS family-08 0.03 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.-.-.-]-30 0.01 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase /-08 0.01 MFS transporter; PAT family; beta-lactamase induction signal-30 0 lipid-A-disaccharide synthase [EC:2.4.1.182]-08 0.04 chemosensory pili system protein ChpA (sensor histidine-08 0.01 histidine transport system ATP-binding protein [EC:3.6.3.21]-08 0.01 fumarylacetoacetase [EC:3.7.1.2]-08 0.02 16S rRNA processing protein RimM-08 0.02 L-lactate dehydrogenase (cytochrome) [EC:1.1.2.3]-01 0.03 molybdopterin oxidoreductase; iron-sulfur binding subunit-08 0.03 thymidylate synthase [EC:2.1.1.45]-30 0 3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.-]-08 0.01 branched-chain amino acid aminotransferase [EC:2.6.1.42]-01 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 606 of 848

signal peptidase II [EC:3.4.23.36]-08 0.02 D-lactate dehydrogenase (cytochrome) [EC:1.1.2.4]-08 0.02 glutamate racemase [EC:5.1.1.3]-08 0.02 arginyl-tRNA synthetase [EC:6.1.1.19]-30 0.01 ribonuclease E [EC:3.1.26.12]-01 0.04 ribose 5-phosphate isomerase A [EC:5.3.1.6]-08 0.03 exoribonuclease II [EC:3.1.13.1]-08 0.01 isovaleryl-CoA dehydrogenase [EC:1.3.99.10]-08 0.03 isocitrate lyase [EC:4.1.3.1]-30 0.01 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]-08 0.02 methylenetetrahydrofolateFor reductase Peer (NADPH) [EC:1.5.1.20]-08Review Only0.03 MSHA biogenesis protein MshG-08 0.01 sulfopyruvate decarboxylase subunit beta [EC:4.1.1.79]-08 0.02 fanconi anemia group M protein [EC:3.6.1.-]-08 0.01 carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]-30 0 glutaminyl-tRNA synthetase [EC:6.1.1.18]-01 0.02 CysQ protein-08 0.03 lipoprotein-releasing system permease protein-30 0.01 hydroxyacylglutathione hydrolase [EC:3.1.2.6]-08 0.03 transcription elongation factor GreA-08 0.03 elongation factor EF-P-08 0.04 pantoate--beta-alanine ligase [EC:6.3.2.1]-08 0.03 sialate O-acetylesterase [EC:3.1.1.53]-08 0.01 bacterioferritin-08 0.02 glutamine amidotransferase [EC:2.4.2.-]-08 0.03 -specific ATP synthase [EC:3.6.3.14]-08 0.02 threonine dehydratase [EC:4.3.1.19]-01 0.02 tenascin-08 0.01 ATP-dependent RNA helicase RhlE [EC:3.6.1.-]-01 0.02 protoheme IX farnesyltransferase [EC:2.5.1.-]-30 0.01 putative protease [EC:3.4.-.-]-08 0 NADH dehydrogenase I subunit G [EC:1.6.5.3]-01 0.03 LPS-assembly protein-01 0.04 trigger factor-01 0.03 phenylacetic acid degradation NADH oxidoreductase-08 0.02 D-amino-acid dehydrogenase [EC:1.4.99.1]-30 0 spermidine synthase [EC:2.5.1.16]-08 0.02 tyrosyl-tRNA synthetase [EC:6.1.1.1]-01 0.03 glycine hydroxymethyltransferase [EC:2.1.2.1]-01 0.03 asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]-08 0.04 3-isopropylmalate dehydrogenase [EC:1.1.1.85]-30 0.01 tryptophanyl-tRNA synthetase [EC:6.1.1.2]-01 0.03 HlyD family secretion protein-08 0 homogentisate 1;2-dioxygenase [EC:1.13.11.5]-08 0.02 porphobilinogen synthase [EC:4.2.1.24]-30 0.01 exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]-08 0.02 methylisocitrate lyase [EC:4.1.3.30]-08 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 607 of 848

triosephosphate isomerase (TIM) [EC:5.3.1.1]-08 0.04 lycopene beta cyclase [EC:1.14.-.-]-08 0.02 dihydroneopterin aldolase [EC:4.1.2.25]-08 0.03 putrescine aminotransferase [EC:2.6.1.-]-08 0.02 aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit A-01 0.04 GDPmannose 4;6-dehydratase [EC:4.2.1.47]-30 0.01 chloride channel protein; CIC family-08 0.02 dimethyladenosine transferase [EC:2.1.1.-]-08 0.04 solute:Na+ symporter; SSS family-30 0.01 Fur family transcriptional regulator; ferric uptake regulator-08 0.03 ribosomal large subunitFor pseudouridine Peer synthase CReview [EC:5.4.99.12]-08 Only0.04 electron transport complex protein RnfA-08 0.01 UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]-30 0.01 aspartate kinase [EC:2.7.2.4]-01 0.03 F-type H+-transporting ATPase subunit delta [EC:3.6.3.14]-08 0.03 methionyl-tRNA synthetase [EC:6.1.1.10]-01 0.04 ribosomal large subunit pseudouridine synthase B [EC:5.4.99.12]-08 0.02 5-aminolevulinate synthase [EC:2.3.1.37]-08 0.01 lipopolysaccharide export system permease protein-30 0 elongation factor EF-Ts-08 0.05 adenosylcobinamide kinase / adenosylcobinamide-phosphate-08 0.01 manganese/iron transport system permease protein-08 0.03 glutaryl-CoA dehydrogenase [EC:1.3.99.7]-30 0.01 putative adenine-specific DNA-methyltransferase [EC:2.1.1.72]-08 0.02 Cu(I)/Ag(I) efflux system membrane protein CusA-08 0.02 phosphoenolpyruvate carboxylase [EC:4.1.1.31]-01 0.02 small subunit ribosomal protein S15-08 0.03 exopolyphosphatase [EC:3.6.1.11]-08 0.02 octopine/nopaline transport system substrate-binding protein-08 0.01 anthranilate phosphoribosyltransferase [EC:2.4.2.18]-30 0 2-methylcitrate synthase [EC:2.3.3.5]-08 0.02 putative membrane protein-01 0.02 carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]-01 0.03 lipoic acid synthetase [EC:2.8.1.8]-30 0.01 molecular chaperone DnaJ-01 0.03 ubiquitin C-08 0.01 carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]-08 0.07 putative permease-08 0.02 chromosomal replication initiator protein-30 0.01 aspartate aminotransferase [EC:2.6.1.1]-01 0.04 apolipoprotein N-acyltransferase [EC:2.3.1.-]-01 0.03 sulfite reductase (ferredoxin) [EC:1.8.7.1]-08 0 phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]-01 0.03 succinyl-CoA synthetase beta subunit [EC:6.2.1.5]-01 0.03 alkaline phosphatase [EC:3.1.3.1]-30 0 N utilization substance protein B-08 0.02 phosphomannomutase [EC:5.4.2.8]-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 608 of 848

pyruvate kinase [EC:2.7.1.40]-01 0.02 tRNA pseudouridine synthase A [EC:5.4.99.12]-08 0.05 bifunctional aspartokinase/homoserine dehydrogenase 1 [EC:2.7.2.4-08 0.02 glycine C-acetyltransferase [EC:2.3.1.29]-30 0 cell division protein FtsA-30 0.01 S-adenosylmethionine synthetase [EC:2.5.1.6]-01 0.04 molecular chaperone IbpA-08 0.01 holliday junction DNA helicase RuvA-08 0.02 methylenetetrahydrofolate dehydrogenase (NADP+) /-30 0.01 succinyl-CoA synthetase beta subunit [EC:6.2.1.5]-30 0.01 dipeptide transport Forsystem substrate-binding Peer protein-08 Review Only0.01 chemotaxis protein MotB-30 0 ubiquinone biosynthesis protein-01 0.04 DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]-08 0.02 SWI/SNF-related matrix-associated actin-dependent regulator of-30 0.02 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]-01 0.02 DNA mismatch repair protein MutS-01 0.02 thiamine biosynthesis protein ThiI-08 0.01 antibiotic transport system permease protein-08 0.03 methyl-accepting chemotaxis protein-30 0.01 glutamate-1-semialdehyde 2;1-aminomutase [EC:5.4.3.8]-01 0.02 UDP-2;3-diacylglucosamine hydrolase [EC:3.6.1.-]-08 0.02 DNA polymerase III subunit delta' [EC:2.7.7.7]-08 0.04 prolyl-tRNA synthetase [EC:6.1.1.15]-01 0.04 DNA ligase (ATP) [EC:6.5.1.1]-30 0.01 cytochrome c oxidase subunit XV assembly protein-01 0.03 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]-08 0.02 methylmalonyl-CoA mutase [EC:5.4.99.2]-01 0.02 cell division protein FtsI (penicillin-binding protein 3)-01 0.04 peptide chain release factor RF-1-01 0.03 deoxyribose-phosphate aldolase [EC:4.1.2.4]-08 0.02 flagellar hook-associated protein 1 FlgK-08 0.02 5'-nucleotidase [EC:3.1.3.5]-01 0.02 transaldolase [EC:2.2.1.2]-08 0.04 thioredoxin 1-08 0.03 coproporphyrinogen III oxidase [EC:1.3.3.3]-30 0.01 small subunit ribosomal protein S12-08 0.03 oligopeptidase B [EC:3.4.21.83]-30 0.01 phosphotransferase system; enzyme I; PtsP [EC:2.7.3.9]-30 0.01 cold shock protein (beta-ribbon; CspA family)-08 0.02 ubiquinone biosynthesis protein-30 0.01 agmatinase [EC:3.5.3.11]-01 0.04 ribonuclease PH [EC:2.7.7.56]-08 0.03 iron complex transport system permease protein-08 0.03 rod shape-determining protein MreB and related proteins-01 0.03 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]-30 0 peroxiredoxin Q/BCP [EC:1.11.1.15]-08 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 609 of 848

putative tungstate transport system substrate-binding protein-08 0.02 putative membrane protein-30 0.01 glutathione S-transferase [EC:2.5.1.18]-30 0 glycerol kinase [EC:2.7.1.30]-30 0.01 cell division protein FtsW-01 0.03 phosphate starvation-inducible protein PhoH and related proteins-01 0.03 phosphogluconate dehydratase [EC:4.2.1.12]-30 0 ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]-08 0.01 beta-alanine--pyruvate transaminase [EC:2.6.1.18]-30 0 tripeptide aminopeptidase [EC:3.4.11.4]-08 0.02 enolase [EC:4.2.1.11]-08For Peer Review Only0.07 small subunit ribosomal protein S5-08 0.03 S-adenosyl-methyltransferase [EC:2.1.1.-]-08 0.04 O-sialoglycoprotein endopeptidase [EC:3.4.24.57]-01 0.03 heat shock 70kDa protein 1/8-08 0.01 two-component system; OmpR family; phosphate regulon response-08 0.02 peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]-30 0.01 glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]-30 0 succinate dehydrogenase iron-sulfur protein [EC:1.3.99.1]-30 0 NADH dehydrogenase I subunit 2 [EC:1.6.5.3]-08 0 antibiotic transport system permease protein-30 0 mannonate dehydratase [EC:4.2.1.8]-08 0.02 Na+:H+ antiporter; NhaC family-08 0.02 putative ATPase-30 0 TatD DNase family protein [EC:3.1.21.-]-30 0.01 biopolymer transport protein ExbD-08 0.03 trk system potassium uptake protein TrkH-01 0.04 2-octaprenyl-3-methyl-6-methoxy-1;4-benzoquinol hydroxylase-08 0.01 DNA topoisomerase III [EC:5.99.1.2]-08 0.02 large subunit ribosomal protein L19-08 0.03 cell division protein FtsZ-01 0.04 type IV pilus assembly protein PilC-08 0.01 UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]-01 0.03 anthranilate synthase component I [EC:4.1.3.27]-30 0.01 oxygen-independent coproporphyrinogen III oxidase [EC:1.3.99.22]-08 0.05 CarD family transcriptional regulator-08 0.01 cobaltochelatase CobS [EC:6.6.1.2]-01 0.02 F-type H+-transporting ATPase subunit a [EC:3.6.3.14]-30 0.01 putative lipoprotein-08 0.03 glycolate oxidase FAD binding subunit-08 0.02 stringent starvation protein A-08 0.02 peptidyl-dipeptidase Dcp [EC:3.4.15.5]-30 0 glycine betaine/proline transport system ATP-binding protein-01 0.03 sarcosine oxidase; subunit delta [EC:1.5.3.1]-08 0.02 NAD(P) transhydrogenase subunit beta [EC:1.6.1.2]-01 0.03 glutathione peroxidase [EC:1.11.1.9]-08 0.03 thiol:disulfide interchange protein DsbC [EC:5.3.4.1]-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 610 of 848

hydroxymethylbilane synthase [EC:2.5.1.61]-30 0.01 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]-01 0.03 PhoH-like ATPase-08 0 molybdopterin biosynthesis protein MoeB-08 0.01 repressor LexA [EC:3.4.21.88]-08 0.03 ubiquitin C-30 0.01 small subunit ribosomal protein S16-08 0.03 trk system potassium uptake protein TrkA-01 0.03 fructose-bisphosphate aldolase; class I [EC:4.1.2.13]-30 0.01 ribosomal RNA small subunit methyltransferase E [EC:2.1.1.-]-08 0.04 mannose-1-phosphateFor guanylyltransferase Peer [EC:2.7.7.22]-08 Review Only0.02 3R-hydroxymyristoyl ACP dehydrase [EC:4.2.1.-]-08 0.02 aminotransferase [EC:2.6.1.-]-30 0.01 dUTP pyrophosphatase [EC:3.6.1.23]-08 0.02 ribulose-phosphate 3-epimerase [EC:5.1.3.1]-30 0.01 molecular chaperone GrpE-08 0.04 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]-01 0.02 tRNA pseudouridine synthase A [EC:5.4.99.12]-30 0 tRNA-(ms[2]io[6]A)-hydroxylase [EC:1.-.-.-]-08 0.02 bilin biosynthesis protein-08 0 putative ATPase-01 0.01 two-component system; OmpR family; phosphate regulon sensor-08 0.02 mandelate racemase [EC:5.1.2.2]-08 0.01 pyruvate; water dikinase [EC:2.7.9.2]-01 0.01 L-serine dehydratase [EC:4.3.1.17]-01 0.01 putative hydrolase of the HAD superfamily-08 0.03 LysR family transcriptional regulator; regulator for metE and metH-08 0.01 transposase-08 0.01 ATP-binding cassette; subfamily B; bacterial MsbA [EC:3.6.3.-]-30 0.01 putative thioredoxin-08 0.01 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase-08 0.03 fatty-acyl-CoA synthase [EC:6.2.1.-]-30 0.01 DNA repair protein RadA/Sms-30 0.01 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]-08 0.01 DNA topoisomerase III [EC:5.99.1.2]-30 0.01 5-deoxy-glucuronate isomerase [EC:5.3.1.-]-08 0.02 ferredoxin--NADP+ reductase [EC:1.18.1.2]-08 0.04 electron transport complex protein RnfG-08 0.01 UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]-08 0.02 purine-nucleoside phosphorylase [EC:2.4.2.1]-08 0.02 two-component system; OmpR family; phosphate regulon response-30 0 trk system potassium uptake protein TrkA-30 0.01 ATP-dependent RNA helicase DeaD-01 0.01 phosphoglucosamine mutase [EC:5.4.2.10]-30 0.01 UDP-glucose 4-epimerase [EC:5.1.3.2]-08 0.04 multidrug resistance protein; MATE family-01 0.02 UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]-01 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 611 of 848

GDP-L-fucose synthase [EC:1.1.1.271]-08 0.03 small subunit ribosomal protein S6-08 0.02 nitrite reductase (NAD(P)H) large subunit [EC:1.7.1.4]-30 0 phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]-01 0.03 N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]-30 0.01 endonuclease III [EC:4.2.99.18]-08 0.04 preprotein translocase subunit SecB-08 0.02 molybdopterin oxidoreductase; membrane subunit [EC:1.2.7.-]-08 0.01 putative protease [EC:3.4.-.-]-30 0 simple sugar transport system substrate-binding protein-08 0.03 seryl-tRNA synthetaseFor [EC:6.1.1.11]-30 Peer Review Only0.01 GDPmannose 4;6-dehydratase [EC:4.2.1.47]-01 0.03 phosphopantothenoylcysteine decarboxylase /-30 0.01 methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]-08 0.02 membrane protease subunit HflC [EC:3.4.-.-]-30 0 xanthine dehydrogenase accessory factor-08 0.02 glutathione reductase (NADPH) [EC:1.8.1.7]-08 0.04 membrane-bound lytic murein transglycosylase B [EC:3.2.1.-]-08 0.02 F-type H+-transporting ATPase subunit b [EC:3.6.3.14]-08 0.04 DNA polymerase III subunit epsilon [EC:2.7.7.7]-01 0.03 LPS-assembly protein-30 0 5-dehydro-2-deoxygluconokinase [EC:2.7.1.92]-01 0.01 IMP dehydrogenase [EC:1.1.1.205]-01 0.04 heme exporter protein C-01 0.02 two-component system; chemotaxis family; sensor kinase CheA-30 0.01 ribosomal large subunit pseudouridine synthase D [EC:5.4.99.12]-01 0.03 MFS transporter; PPP family; 3-phenylpropionic acid transporter-08 0.01 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase-30 0 porphobilinogen synthase [EC:4.2.1.24]-01 0.03 septum formation protein-08 0.03 bifunctional enzyme involved in thiolation and methylation of tRNA-01 0.03 histidine ammonia-lyase [EC:4.3.1.3]-01 0.01 penicillin amidase [EC:3.5.1.11]-08 0.02 multiple sugar transport system ATP-binding protein-08 0.03 inosose dehydratase [EC:4.2.1.44]-08 0.02 ribokinase [EC:2.7.1.15]-08 0.02 pyruvate kinase [EC:2.7.1.40]-30 0.01 3-isopropylmalate dehydrogenase [EC:1.1.1.85]-01 0.03 DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]-01 0.03 rod shape-determining protein MreC-08 0.04 cobalamin biosynthesis protein CbiD-08 0.02 carbamoyltransferase [EC:2.1.3.-]-01 0.03 ATP-dependent HslUV protease ATP-binding subunit HslU-30 0.01 FKBP12-rapamycin complex-associated protein-30 0.01 molybdopterin biosynthesis protein MoeA-30 0.01 alanine dehydrogenase [EC:1.4.1.1]-01 0.03 D-xylose transport system substrate-binding protein-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 612 of 848

ATP-dependent DNA helicase RecQ [EC:3.6.1.-]-01 0.02 DNA mismatch repair protein MutL-30 0.01 leucyl/phenylalanyl-tRNA--protein transferase [EC:2.3.2.6]-08 0.02 Cu(I)/Ag(I) efflux system membrane protein CusA-30 0 flagellar P-ring protein precursor FlgI-08 0.03 sigma-54 specific transcriptional regulator; flagellar regulatory-08 0.02 sec-independent protein translocase protein TatB-30 0.01 phosphatidylglycerophosphatase A [EC:3.1.3.27]-08 0.02 acetyl-CoA carboxylase carboxyl transferase subunit beta-30 0 large subunit ribosomal protein L2-30 0.02 Na+:H+ antiporter; NhaAFor family-08 Peer Review Only0.01 cytosine deaminase [EC:3.5.4.1]-08 0.02 phage shock protein A-08 0 Fe/S biogenesis protein NfuA-08 0.01 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) [EC:1.2.1.59]-08 0 transaldolase [EC:2.2.1.2]-30 0 asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]-01 0.03 phosphoethanolamine transferase-08 0.01 dephospho-CoA kinase [EC:2.7.1.24]-08 0.02 two-component system; chemotaxis family; response regulator CheB-30 0 alpha-galactosidase [EC:3.2.1.22]-08 0.02 D-xylose transport system permease protein-08 0.01 aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit B-01 0.04 adenylylsulfate reductase; subunit A [EC:1.8.99.2]-01 0.03 uroporphyrinogen decarboxylase [EC:4.1.1.37]-01 0.03 cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]-01 0.02 X-Pro dipeptidase [EC:3.4.13.9]-30 0 Bax protein-08 0.01 putative flavoprotein involved in K+ transport-08 0.02 DnaK suppressor protein-08 0.03 ATP-dependent HslUV protease ATP-binding subunit HslU-01 0.03 formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]-08 0.04 UDP-N-acetylmuramoylalanyl-D-glutamate--2;6-diaminopimelate ligase-30 0.01 S-adenosyl-methyltransferase [EC:2.1.1.-]-30 0.01 electron-transferring-flavoprotein dehydrogenase [EC:1.5.5.1]-01 0.03 chalcone synthase [EC:2.3.1.74]-08 0.02 lipoprotein-08 0.03 undecaprenyl-diphosphatase [EC:3.6.1.27]-08 0.04 RNA methyltransferase; TrmH family; group 2 [EC:2.1.1.-]-08 0.02 molecular chaperone HtpG-01 0.02 proton-dependent oligopeptide transporter; POT family-08 0.03 thioredoxin 1-30 0 ATP-dependent DNA helicase DinG [EC:3.6.1.-]-30 0 large subunit ribosomal protein L25-08 0.04 DNA-directed RNA polymerase II subunit B [EC:2.7.7.6]-30 0.01 glycerol kinase [EC:2.7.1.30]-01 0.02 iron(III) transport system substrate-binding protein-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 613 of 848

histidinol-phosphate aminotransferase [EC:2.6.1.9]-30 0.01 malate dehydrogenase (quinone) [EC:1.1.5.4]-08 0.01 nitrogen regulatory protein P-II 2-08 0.02 DNA (cytosine-5-)-methyltransferase [EC:2.1.1.37]-01 0.02 ribosomal RNA large subunit methyltransferase N [EC:2.1.1.-]-30 0.01 glycine betaine/proline transport system substrate-binding protein-30 0.01 large subunit ribosomal protein L16-08 0.03 RNA polymerase sigma-32 factor-30 0 starch phosphorylase [EC:2.4.1.1]-30 0 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase)-08 0.05 DNA-directed RNA polymeraseFor subunitPeer alpha [EC:2.7.7.6]-30 Review Only0.01 pyruvate dehydrogenase E2 component (dihydrolipoamide-01 0.03 6-phosphogluconolactonase [EC:3.1.1.31]-08 0.02 enolase [EC:4.2.1.11]-01 0.04 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase-30 0.01 butyryl-CoA dehydrogenase [EC:1.3.99.2]-08 0.02 flagellar biosynthesis protein FlhG-08 0.02 uridine kinase [EC:2.7.1.48]-08 0.01 single-stranded-DNA-specific exonuclease [EC:3.1.-.-]-01 0.04 selenide; water dikinase [EC:2.7.9.3]-08 0.04 flavodoxin II-08 0.01 tRNA (guanine-N2-)-methyltransferase [EC:2.1.1.32]-08 0 membrane protease subunit HflK [EC:3.4.-.-]-30 0.01 peptidyl-dipeptidase A [EC:3.4.15.1]-08 0.01 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]-08 0.04 D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]-08 0.02 lipoate-protein ligase A [EC:2.7.7.63]-08 0.01 aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit B-30 0.01 phosphatidylglycerol:prolipoprotein diacylglycerol transferase-08 0.03 DNA repair protein RecN (Recombination protein N)-30 0.01 methionyl aminopeptidase [EC:3.4.11.18]-30 0.01 rod shape determining protein RodA-01 0.03 TolB protein-30 0 sarcosine oxidase; subunit beta [EC:1.5.3.1]-01 0.04 carbonic anhydrase [EC:4.2.1.1]-08 0.03 membrane protein required for colicin V production-08 0.02 riboflavin synthase beta chain [EC:2.5.1.-]-08 0.03 argininosuccinate lyase [EC:4.3.2.1]-01 0.04 glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]-08 0.01 dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]-08 0.02 chlorophyll synthase [EC:2.5.1.62]-08 0 excinuclease ABC subunit C-30 0.01 homoserine O-succinyltransferase [EC:2.3.1.46]-08 0.02 elongation factor EF-3-08 0.01 two-component system; NtrC family; nitrogen regulation sensor-01 0.03 two-component system; NtrC family; nitrogen regulation sensor-30 0 sorbitol/mannitol transport system substrate-binding protein-08 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 614 of 848

indole-3-glycerol phosphate synthase [EC:4.1.1.48]-08 0.03 orotate phosphoribosyltransferase [EC:2.4.2.10]-30 0 N-acetylneuraminate synthase [EC:2.5.1.56]-30 0 enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9]-30 0.01 2;4-dienoyl-CoA reductase (NADPH2) [EC:1.3.1.34]-30 0 multidrug resistance protein; MATE family-30 0.01 chaperonin GroES-08 0.03 flagellar motor switch protein FliM-08 0.01 peptidyl-tRNA hydrolase; PTH1 family [EC:3.1.1.29]-08 0.04 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase-08 0 uracil phosphoribosyltransferaseFor Peer [EC:2.4.2.9]-08 Review Only0.02 homoserine dehydrogenase [EC:1.1.1.3]-30 0.01 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase)-08 0.03 UDP-glucose 4-epimerase [EC:5.1.3.2]-30 0.01 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase-01 0.03 SWI/SNF-related matrix-associated actin-dependent regulator of-08 0.01 arylsulfatase A [EC:3.1.6.8]-08 0 phosphate starvation-inducible protein PhoH and related proteins-30 0.01 C4-dicarboxylate transporter; DctQ subunit-08 0.01 inorganic phosphate transporter; PiT family-30 0.01 chloramphenicol-sensitive protein RarD-08 0.02 methyltransferase [EC:2.1.1.-]-30 0 ribonuclease J [EC:3.1.-.-]-08 0 phosphopantothenoylcysteine decarboxylase /-01 0.03 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase /-08 0.01 fructose-bisphosphate aldolase; class I [EC:4.1.2.13]-01 0.02 F-type H+-transporting ATPase subunit gamma [EC:3.6.3.14]-01 0.03 S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:5.-.-.-]-30 0 alkaline phosphatase [EC:3.1.3.1]-08 0.01 glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]-30 0 2-methylcitrate dehydratase [EC:4.2.1.79]-01 0.02 RNA polymerase sigma-70 factor; ECF subfamily-30 0.01 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase)-30 0 octopine/nopaline transport system permease protein-08 0.01 zinc transport system substrate-binding protein-30 0.01 ATP-dependent helicase HepA [EC:3.6.1.-]-30 0 formimidoylglutamate deiminase [EC:3.5.3.13]-08 0.01 ribosome-binding factor A-08 0.01 ADP-ribose pyrophosphatase [EC:3.6.1.13]-08 0.02 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase-08 0.05 precorrin-6Y C5;15-methyltransferase / precorrin-8W decarboxylase-08 0.02 phosphoribosylamine--glycine ligase [EC:6.3.4.13]-01 0.03 histidine ammonia-lyase [EC:4.3.1.3]-30 0.01 periplasmic protein TonB-30 0 ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.2]-08 0.03 phosphoglycerate mutase [EC:5.4.2.1]-01 0.03 thymidine phosphorylase [EC:2.4.2.4]-08 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 615 of 848

3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.60]-08 0.03 ribose transport system ATP-binding protein [EC:3.6.3.17]-08 0.01 cystathionine beta-lyase [EC:4.4.1.8]-08 0.03 phospholipase D [EC:3.1.4.4]-30 0.01 sulfonate/nitrate/taurine transport system ATP-binding protein-30 0.01 flavodoxin I-08 0 anhydro-N-acetylmuramic acid kinase [EC:2.7.1.-]-30 0 cystathionine gamma-synthase [EC:2.5.1.48]-08 0.03 large subunit ribosomal protein L10-08 0.04 coproporphyrinogen III oxidase [EC:1.3.3.3]-08 0.04 alanine racemase [EC:5.1.1.1]-08For Peer Review Only0.03 periplasmic protein TonB-08 0.02 D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95]-01 0.02 segregation and condensation protein A-08 0.03 nucleoside-diphosphate kinase [EC:2.7.4.6]-08 0.03 DNA polymerase V-01 0.02 phytoene dehydrogenase [EC:1.14.99.-]-01 0.03 thymidylate synthase [EC:2.1.1.45]-01 0.02 nitrogen regulatory protein P-II 1-08 0.01 glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]-08 0.02 chaperonin GroES-01 0.02 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [EC:1.17.1.2]-30 0.01 dGTPase [EC:3.1.5.1]-30 0 nitrogen fixation protein NifU and related proteins-08 0.02 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase-08 0.02 NADH dehydrogenase I subunit M [EC:1.6.5.3]-30 0 magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]-08 0 NADH dehydrogenase I subunit G [EC:1.6.5.3]-30 0.01 urease alpha subunit [EC:3.5.1.5]-08 0.01 ATP-dependent helicase HrpA [EC:3.6.1.-]-30 0.01 PmbA protein-30 0 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]-30 0.01 two-component system; OmpR family; response regulator-08 0.02 urocanate hydratase [EC:4.2.1.49]-30 0.01 sorbitol/mannitol transport system permease protein-08 0.02 carbamoyltransferase [EC:2.1.3.-]-30 0 acetyl-CoA carboxylase carboxyl transferase subunit alpha-30 0 anaerobic dimethyl sulfoxide reductase subunit C (DMSO reductase-08 0.01 phytoene synthase [EC:2.5.1.32]-08 0.03 chromosome partitioning protein-01 0.03 uncharacterized membrane protein-08 0.01 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [EC:1.17.1.2]-01 0.02 altronate hydrolase [EC:4.2.1.7]-08 0.01 DNA-directed RNA polymerase; mitochondrial [EC:2.7.7.6]-08 0 malate dehydrogenase [EC:1.1.1.37]-01 0.03 fructokinase [EC:2.7.1.4]-30 0 iron complex transport system ATP-binding protein [EC:3.6.3.34]-08 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 616 of 848

magnesium chelatase subunit I [EC:6.6.1.1]-30 0 ferrous iron transport protein B-08 0.02 ketol-acid reductoisomerase [EC:1.1.1.86]-01 0.03 ribosome-associated heat shock protein Hsp15-08 0.01 heme exporter protein B-08 0.02 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase-30 0.01 S-adenosyl-methyltransferase [EC:2.1.1.-]-01 0.02 basic membrane protein A and related proteins-08 0.02 virulence factor-30 0.01 DNA ligase (ATP) [EC:6.5.1.1]-01 0.01 zinc protease [EC:3.4.99.-]-30For Peer Review Only 0 argininosuccinate synthase [EC:6.3.4.5]-01 0.03 allantoicase [EC:3.5.3.4]-08 0.01 clathrin; heavy polypeptide-30 0.01 succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]-30 0.01 chorismate synthase [EC:4.2.3.5]-01 0.03 chromate transporter-08 0.02 glycine betaine/proline transport system permease protein-30 0.01 cytochrome b6-30 0.01 succinylglutamic semialdehyde dehydrogenase [EC:1.2.1.71]-08 0.01 peptide chain release factor RF-2-01 0.03 lipoic acid synthetase [EC:2.8.1.8]-01 0.02 putative ABC transport system permease protein-08 0.03 large subunit ribosomal protein L21-08 0.03 beta-alanine--pyruvate transaminase [EC:2.6.1.18]-01 0.03 urease accessory protein-30 0 glutamate dehydrogenase [EC:1.4.1.2]-30 0.01 lysyl-tRNA synthetase; class II [EC:6.1.1.6]-30 0.01 sec-independent protein translocase protein TatC-30 0.01 exodeoxyribonuclease I [EC:3.1.11.1]-01 0.03 cystathionine beta-synthase [EC:4.2.1.22]-08 0.02 SecD/SecF fusion protein-30 0 regulator of ribonuclease activity A-08 0.01 elongation factor EF-2 [EC:3.6.5.3]-08 0.01 6-pyruvoyl tetrahydrobiopterin synthase [EC:4.2.3.12]-08 0.02 cytochrome c biogenesis protein-08 0.01 protoheme IX farnesyltransferase [EC:2.5.1.-]-01 0.03 DNA topoisomerase II [EC:5.99.1.3]-01 0.01 sigma-B regulation protein RsbU (phosphoserine phosphatase)-08 0 flagellum-specific ATP synthase [EC:3.6.3.14]-30 0 GTP cyclohydrolase I [EC:3.5.4.16]-30 0 exonuclease SbcC-08 0.01 dolichyl-diphosphooligosaccharide--protein glycosyltransferase-30 0.01 cytochrome c-08 0.01 lactoylglutathione lyase [EC:4.4.1.5]-08 0.03 ribosomal RNA small subunit methyltransferase D [EC:2.1.1.52]-08 0.01 ribosome recycling factor-08 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 617 of 848

intracellular septation protein-08 0.01 ATP-dependent DNA helicase Rep [EC:3.6.1.-]-30 0 membrane-bound lytic murein transglycosylase D [EC:3.2.1.-]-30 0.01 pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]-30 0.01 putative ABC transport system substrate-binding protein-08 0.01 3-dehydroquinate synthase [EC:4.2.3.4]-30 0.01 L-aspartate oxidase [EC:1.4.3.16]-30 0.01 photosystem II reaction center 13kDa protein-30 0.01 acetyl-CoA acyltransferase [EC:2.3.1.16]-30 0 lipoprotein NlpD-08 0.01 cytochrome c oxidaseFor subunit III Peer[EC:1.9.3.1]-30 Review Only0.01 uroporphyrinogen-III synthase [EC:4.2.1.75]-08 0.02 putative hydrolases of HD superfamily-08 0.01 geranyl-CoA carboxylase beta subunit [EC:6.4.1.5]-08 0.02 TolB protein-01 0.03 ferredoxin-nitrite reductase [EC:1.7.7.1]-08 0 MFS transporter; DHA1 family; tetracycline resistance protein-08 0.01 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]-08 0.01 erythronate-4-phosphate dehydrogenase [EC:1.1.1.290]-08 0.02 simple sugar transport system ATP-binding protein [EC:3.6.3.17]-30 0 tRNA/rRNA methyltransferase [EC:2.1.1.-]-08 0.03 prephenate dehydrogenase [EC:1.3.1.12]-08 0.02 large subunit ribosomal protein L22-08 0.02 2;3;4;5-tetrahydropyridine-2-carboxylate N-succinyltransferase-30 0.01 molecular chaperone Hsp33-08 0.03 putative mRNA 3-end processing factor-08 0 ribonuclease HII [EC:3.1.26.4]-30 0 exodeoxyribonuclease VII large subunit [EC:3.1.11.6]-30 0 putative translation factor-30 0 peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]-30 0 glycogen operon protein GlgX [EC:3.2.1.-]-30 0 iron complex transport system permease protein-30 0.01 multiple sugar transport system permease protein-01 0.03 type IV pilus assembly protein PilC-30 0 guanosine-5'-triphosphate;3'-diphosphate pyrophosphatase-08 0 ApaG protein-08 0.01 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]-08 0.02 transcriptional antiterminator NusG-30 0 general L-amino acid transport system substrate-binding protein-01 0.02 flagellar biosynthesis protein FlhA-30 0 universal stress protein A-08 0.01 NAD(P) transhydrogenase subunit alpha [EC:1.6.1.2]-01 0.03 phosphate transport system substrate-binding protein-08 0.01 diaminopimelate decarboxylase [EC:4.1.1.20]-01 0.03 bile acid:Na+ symporter; BASS family-08 0.01 glutamate N-acetyltransferase / amino-acid N-acetyltransferase-30 0.01 crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]-08 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 618 of 848

phosphatidate cytidylyltransferase [EC:2.7.7.41]-08 0.03 ankyrin-08 0.01 urea transport system permease protein-08 0 asparaginyl-tRNA synthetase [EC:6.1.1.22]-08 0.02 ferrochelatase [EC:4.99.1.1]-30 0.01 phosphoserine aminotransferase [EC:2.6.1.52]-30 0.01 phycobilisome rod-core linker protein-08 0 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]-01 0.04 phosphoribosylaminoimidazole-succinocarboxamide synthase-30 0.01 DNA polymerase III subunit delta [EC:2.7.7.7]-30 0 large subunit ribosomalFor protein L23-08Peer Review Only0.01 gyoxylate/hydroxypyruvate reductase A [EC:1.1.1.79 1.1.1.81]-08 0.02 CysZ protein-08 0.01 type I restriction enzyme; S subunit [EC:3.1.21.3]-08 0.01 L-asparaginase [EC:3.5.1.1]-08 0.02 putative MFS transporter; AGZA family; xanthine/uracil permease-30 0.01 multicomponent Na+:H+ antiporter subunit D-30 0.01 translation initiation factor IF-3-08 0.03 molybdenum cofactor biosynthesis protein E-08 0.02 creatinase [EC:3.5.3.3]-08 0.01 propionyl-CoA carboxylase beta chain [EC:6.4.1.3]-30 0.01 large subunit ribosomal protein L7/L12-08 0.03 zinc/manganese transport system permease protein-08 0 queuosine biosynthesis protein QueC-08 0.02 ribosome biogenesis GTPase [EC:3.6.1.-]-30 0 multiple antibiotic resistance protein-08 0.02 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase-01 0.03 DNA repair protein RadA/Sms-01 0.02 tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase-08 0 ATP-dependent DNA helicase DinG [EC:3.6.1.-]-01 0.01 nitrite reductase (NAD(P)H) large subunit [EC:1.7.1.4]-08 0.01 NADH dehydrogenase I subunit J [EC:1.6.5.3]-08 0.02 penicillin-insensitive murein endopeptidase [EC:3.4.24.-]-08 0.01 DNA polymerase V-30 0 succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]-01 0.03 enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9]-01 0.03 dTMP kinase [EC:2.7.4.9]-08 0.02 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]-08 0.04 tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.25-08 0.02 2-dehydropantoate 2-reductase [EC:1.1.1.169]-08 0.03 prolyl oligopeptidase [EC:3.4.21.26]-30 0.01 cytochrome c oxidase subunit XI assembly protein-08 0.02 ATP-dependent HslUV protease; peptidase subunit HslV [EC:3.4.25.-]-08 0.03 hemolysin III-08 0.01 propionyl-CoA carboxylase beta chain [EC:6.4.1.3]-08 0.04 aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]-01 0.03 isocitrate lyase [EC:4.1.3.1]-01 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 619 of 848

iron(III) transport system substrate-binding protein-01 0.03 chaperonin GroES-30 0 competence/damage-inducible protein CinA-08 0.02 diaminopimelate epimerase [EC:5.1.1.7]-08 0.04 small subunit ribosomal protein S2-30 0.01 putrescine transport system substrate-binding protein-08 0.01 citrate synthase [EC:2.3.3.1]-01 0.02 putative toluene tolerance protein-08 0.01 ribosomal RNA large subunit methyltransferase E [EC:2.1.1.-]-08 0.03 large subunit ribosomal protein L5-08 0.03 single-strand DNA-bindingFor protein-30 Peer Review Only 0 competence protein ComEC-08 0.02 betaine-aldehyde dehydrogenase [EC:1.2.1.8]-30 0.01 farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]-30 0 molecular chaperone GrpE-30 0 fused signal recognition particle receptor-01 0.03 myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]-01 0.02 PhnP protein-08 0.02 carboxypeptidase PM20D1 [EC:3.4.17.-]-08 0.01 tRNA (guanine-N1-)-methyltransferase [EC:2.1.1.31]-30 0 large subunit ribosomal protein L14-08 0.02 phosphomethylpyrimidine kinase [EC:2.7.4.7]-08 0.01 sodium transport system ATP-binding protein-08 0.01 cysteine desulfuration protein SufE-08 0.01 lipid-A-disaccharide synthase [EC:2.4.1.182]-01 0.03 tubulin alpha-08 0.01 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]-08 0.02 DNA polymerase III subunit delta' [EC:2.7.7.7]-30 0 sulfonate/nitrate/taurine transport system substrate-binding protein-30 0.01 MSHA biogenesis protein MshI-08 0.01 DNA polymerase IV [EC:2.7.7.7]-30 0.01 ribonuclease HII [EC:3.1.26.4]-08 0.03 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]-01 0.02 4-alpha-glucanotransferase [EC:2.4.1.25]-08 0 2-deoxy-D-gluconate 3-dehydrogenase [EC:1.1.1.125]-08 0.01 ribonuclease G [EC:3.1.26.-]-30 0 MraZ protein-08 0.02 acetylornithine/N-succinyldiaminopimelate aminotransferase-30 0 citronellyl-CoA dehydrogenase [EC:1.3.99.-]-08 0.01 NADH dehydrogenase I subunit 1 [EC:1.6.5.3]-08 0 FKBP-type peptidyl-prolyl cis-trans isomerase SlpA [EC:5.2.1.8]-08 0.01 PmbA protein-01 0.03 outer membrane channel protein TolC-30 0 molybdenum cofactor biosynthesis protein C-08 0.02 conserved hypothetical protein-08 0.03 menaquinone-specific isochorismate synthase [EC:5.4.4.2]-08 0 light-independent protochlorophyllide reductase subunit N-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 620 of 848

RNA methyltransferase; TrmH family [EC:2.1.1.-]-30 0 prolyl oligopeptidase [EC:3.4.21.26]-08 0.02 NADH dehydrogenase I subunit E [EC:1.6.5.3]-08 0.02 DNA polymerase III subunit beta [EC:2.7.7.7]-01 0.03 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]-30 0.01 D-amino-acid dehydrogenase [EC:1.4.99.1]-01 0.03 phosphoadenosine phosphosulfate reductase [EC:1.8.4.8]-08 0.01 O-sialoglycoprotein endopeptidase [EC:3.4.24.57]-30 0.01 A/G-specific adenine glycosylase [EC:3.2.2.-]-01 0.02 sulfite reductase (NADPH) flavoprotein alpha-component [EC:1.8.1.2]-08 0.02 exodeoxyribonucleaseFor V [EC:3.1.11.5]-08 Peer Review Only0.02 DNA polymerase III subunit delta [EC:2.7.7.7]-01 0.03 glutaminyl-tRNA synthetase [EC:6.1.1.18]-30 0.01 RNA methyltransferase; TrmH family-08 0.01 ATP phosphoribosyltransferase regulatory subunit-30 0 serralysin [EC:3.4.24.40]-08 0.01 dTDP-glucose 4;6-dehydratase [EC:4.2.1.46]-01 0.02 DNA mismatch repair protein MutS2-08 0.01 histidinol-phosphate aminotransferase [EC:2.6.1.9]-01 0.03 tubulin beta-08 0.01 alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]-08 0.01 DNA recombination protein RmuC-01 0.03 monoamine oxidase [EC:1.4.3.4]-08 0.01 elongation factor EF-Ts-30 0 ATP-dependent RNA helicase SrmB [EC:2.7.7.-]-08 0.01 glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3]-08 0.01 two-component system; OmpR family; osmolarity sensor histidine-01 0.02 shikimate kinase [EC:2.7.1.71]-08 0.03 exonuclease SbcC-30 0 cobalamin biosynthesis protein CbiG-08 0.01 diaminopimelate decarboxylase [EC:4.1.1.20]-30 0.01 UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]-01 0.03 phosphoglucosamine mutase [EC:5.4.2.10]-01 0.03 dCTP deaminase [EC:3.5.4.13]-08 0.03 exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]-30 0 phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]-01 0.03 NADH dehydrogenase I subunit N [EC:1.6.5.3]-01 0.03 2-octaprenyl-6-methoxyphenol hydroxylase [EC:1.14.13.-]-30 0 acetylornithine/N-succinyldiaminopimelate aminotransferase-01 0.02 arginine:pyruvate transaminase [EC:2.6.1.84]-08 0.02 phosphoglucomutase [EC:5.4.2.2]-30 0 ATP-dependent Clp protease ATP-binding subunit ClpA-01 0.02 glutamate N-acetyltransferase / amino-acid N-acetyltransferase-01 0.03 V-type H+-transporting ATPase subunit I [EC:3.6.3.14]-30 0.01 acyl-CoA dehydrogenase [EC:1.3.99.-]-30 0 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]-30 0.01 UDPglucose 6-dehydrogenase [EC:1.1.1.22]-01 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 621 of 848

7-cyano-7-deazaguanine reductase [EC:1.7.1.13]-08 0.02 putative tungstate transport system permease protein-08 0.01 glutamate 5-kinase [EC:2.7.2.11]-30 0.01 ribosome recycling factor-30 0 Fur family transcriptional regulator; iron response regulator-08 0.01 preprotein translocase subunit SecD-01 0.03 magnesium chelatase family protein-30 0 transformation/transcription domain-associated protein-30 0.01 holliday junction DNA helicase RuvB-01 0.01 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]-01 0.03 NAD+ synthase (glutamine-hydrolysing)For Peer [EC:6.3.5.1]-30 Review Only0.01 Na+-transporting NADH:ubiquinone oxidoreductase subunit E-08 0.02 L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]-08 0.01 phosphoribosylaminoimidazole-succinocarboxamide synthase-01 0.02 ribonuclease T [EC:3.1.13.-]-08 0.01 glycolate oxidase [EC:1.1.3.15]-01 0.01 adenylylsulfate kinase [EC:2.7.1.25]-08 0.01 lipid-A-disaccharide synthase [EC:2.4.1.182]-30 0 guanylate kinase [EC:2.7.4.8]-08 0.03 diaminopimelate epimerase [EC:5.1.1.7]-30 0.01 Fe-S cluster assembly ATP-binding protein-08 0.02 LacI family transcriptional regulator; gluconate utilization system-08 0.01 acetoin utilization protein AcuC-08 0.01 general L-amino acid transport system substrate-binding protein-30 0 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]-30 0.01 flagellar hook protein FlgE-08 0.01 5;6-dimethylbenzimidazole biosynthesis protein BluB-08 0.01 sodium transport system permease protein-08 0.01 methylenetetrahydrofolate dehydrogenase (NADP+) /-01 0.03 phosphoglycerate kinase [EC:2.7.2.3]-01 0.03 putative ABC transport system ATP-binding protein-30 0 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]-30 0 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase)-30 0 lactose/L-arabinose transport system permease protein-08 0 fumarate reductase flavoprotein subunit [EC:1.3.99.1]-08 0.01 sarcosine dehydrogenase [EC:1.5.99.1]-30 0 Fe-S cluster assembly protein SufD-01 0.02 xylulokinase [EC:2.7.1.17]-30 0 transformation/transcription domain-associated protein-08 0 long-chain acyl-CoA synthetase [EC:6.2.1.3]-01 0.03 cytochrome b6-08 0.01 modification methylase [EC:2.1.1.72]-01 0.02 ferredoxin; 2Fe-2S-08 0.02 OmpA-OmpF porin; OOP family-08 0.01 spermidine synthase [EC:2.5.1.16]-30 0 galactonate dehydratase [EC:4.2.1.6]-08 0.01 twitching motility protein PilT-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 622 of 848

NAD+ diphosphatase [EC:3.6.1.22]-08 0.02 ribonuclease III [EC:3.1.26.3]-08 0.03 ribosomal RNA small subunit methyltransferase B [EC:2.1.1.-]-30 0 formyl-CoA transferase [EC:2.8.3.16]-08 0.01 putative hydrolase of the HAD superfamily-30 0 glycine amidinotransferase [EC:2.1.4.1]-01 0.02 cytochrome c biogenesis protein CcmG; thiol:disulfide interchange-08 0.02 Na+-transporting NADH:ubiquinone oxidoreductase subunit D-08 0.02 UDP-N-acetylmuramoylalanyl-D-glutamate--2;6-diaminopimelate ligase-01 0.02 glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]-01 0.03 S-formylglutathioneFor hydrolase [EC:3.1.2.12]-30Peer Review Only 0 thymidine kinase [EC:2.7.1.21]-08 0.02 geranylgeranyl diphosphate synthase; type II [EC:2.5.1.1 2.5.1.10-08 0 6-phosphofructokinase [EC:2.7.1.11]-30 0.01 rod shape determining protein RodA-30 0 heme exporter protein A [EC:3.6.3.41]-08 0.02 molybdopterin-guanine dinucleotide biosynthesis protein A-08 0.02 molybdate transport system ATP-binding protein [EC:3.6.3.29]-08 0.02 thymidylate synthase [EC:2.1.1.45]-08 0.03 adenylate cyclase [EC:4.6.1.1]-08 0.01 cold shock protein (beta-ribbon; CspA family)-30 0 carbon-monoxide dehydrogenase medium subunit [EC:1.2.99.2]-08 0.01 beta-N-acetylhexosaminidase [EC:3.2.1.52]-30 0 farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]-08 0.03 cytochrome b6-f complex subunit 4-30 0.01 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]-01 0.02 molecular chaperone HscA-01 0.01 NADH dehydrogenase I subunit K [EC:1.6.5.3]-08 0.01 GTP cyclohydrolase II [EC:3.5.4.25]-08 0.02 glycerate dehydrogenase [EC:1.1.1.29]-08 0.01 glycolate oxidase iron-sulfur subunit-01 0.01 ribosomal-protein-alanine N-acetyltransferase [EC:2.3.1.128]-08 0.02 ferrochelatase [EC:4.99.1.1]-01 0.03 ubiquitin carboxyl-terminal hydrolase 14 [EC:3.1.2.15]-30 0.01 6-phosphofructokinase [EC:2.7.1.11]-01 0.02 glutamate--cysteine ligase [EC:6.3.2.2]-01 0.03 mercuric reductase [EC:1.16.1.1]-30 0.01 nitrate reductase catalytic subunit [EC:1.7.99.4]-30 0 cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]-30 0.01 large subunit ribosomal protein L1-08 0.05 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX [EC:4.1.1.-]-08 0.02 two-component system; OmpR family; osmolarity sensor histidine-30 0 preprotein translocase subunit SecF-30 0 rare lipoprotein A-08 0.01 phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]-30 0.01 photosystem I subunit II-30 0.01 biopolymer transport protein TolQ-08 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 623 of 848

glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]-30 0.01 putative endonuclease-08 0.01 succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]-30 0.01 phosphoglycolate phosphatase [EC:3.1.3.18]-30 0 arginase [EC:3.5.3.1]-08 0.01 arabinose-5-phosphate isomerase [EC:5.3.1.13]-30 0 NADH dehydrogenase I subunit D [EC:1.6.5.3]-30 0 UDP-N-acetylmuramoylalanyl-D-glutamyl-2;6-diaminopimelate--D-alanyl--01 0.03 translation initiation factor IF-2 unclassified subunit-08 0 RNA methyltransferase; TrmA family [EC:2.1.1.-]-30 0 cyclase HisF [EC:4.1.3.-]-01For Peer Review Only0.03 octaprenyl diphosphate synthase [EC:2.5.1.-]-01 0.02 two-component system; LytT family; response regulator-08 0.01 regulator of sigma E protease [EC:3.4.24.-]-01 0.03 outer membrane usher protein-08 0.01 photosystem II PsbO protein-08 0 cytochrome c-type biogenesis protein CcmE-08 0.02 general secretion pathway protein E-30 0 glutamyl-tRNA reductase [EC:1.2.1.70]-01 0.01 glutathione peroxidase [EC:1.11.1.9]-30 0 large subunit ribosomal protein L1-30 0.01 type IV pilus assembly protein PilY1-01 0.02 phosphoglucomutase [EC:5.4.2.2]-08 0 DNA polymerase delta subunit 1 [EC:2.7.7.7]-08 0 2-methylcitrate synthase [EC:2.3.3.5]-30 0 molybdate transport system permease protein-08 0.02 transcription elongation factor GreB-08 0.01 large subunit ribosomal protein L3-08 0.04 phytoene dehydrogenase [EC:1.14.99.-]-30 0 phosphoserine aminotransferase [EC:2.6.1.52]-01 0.02 cytochrome o ubiquinol oxidase subunit II [EC:1.10.3.-]-08 0.01 lipoyl(octanoyl) transferase [EC:2.3.1.181]-30 0 pyrroloquinoline quinone biosynthesis protein B-08 0.01 Na+-transporting NADH:ubiquinone oxidoreductase subunit A-30 0 light-independent protochlorophyllide reductase subunit L-08 0 ribose-phosphate pyrophosphokinase [EC:2.7.6.1]-01 0.03 L-aspartate oxidase [EC:1.4.3.16]-01 0.01 small subunit ribosomal protein S20-08 0.02 acetylglutamate kinase [EC:2.7.2.8]-30 0 F-type H+-transporting ATPase subunit c [EC:3.6.3.14]-08 0.02 homoserine kinase [EC:2.7.1.39]-08 0.01 glucose-6-phosphate isomerase [EC:5.3.1.9]-01 0.02 glutamate--cysteine ligase [EC:6.3.2.2]-30 0.01 glutamate synthase (NADPH/NADH) [EC:1.4.1.13 1.4.1.14]-30 0.01 Na+:H+ antiporter; NhaA family-01 0.01 F-type H+-transporting ATPase subunit a [EC:3.6.3.14]-01 0.03 S-adenosylmethionine decarboxylase [EC:4.1.1.50]-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 624 of 848

D-alanine-D-alanine ligase [EC:6.3.2.4]-01 0.03 glutathione reductase (NADPH) [EC:1.8.1.7]-30 0.01 phosphohistidine phosphatase [EC:3.1.3.-]-08 0.01 serine protein kinase-08 0 electron transfer flavoprotein beta subunit-30 0 dihydropteroate synthase [EC:2.5.1.15]-08 0.04 two-component system; OmpR family; sensor histidine kinase TorS-08 0.01 tRNA pseudouridine synthase C [EC:5.4.99.12]-08 0.01 pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]-08 0.03 ArsR family transcriptional regulator-08 0.01 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)-30For Peer Review Only 0 homoserine dehydrogenase [EC:1.1.1.3]-01 0.03 exodeoxyribonuclease III [EC:3.1.11.2]-30 0.01 inorganic phosphate transporter; PiT family-01 0.01 peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]-01 0.01 microsomal epoxide hydrolase [EC:3.3.2.9]-08 0.01 sulfate permease; SulP family-30 0 malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]-30 0 chemosensory pili system protein ChpA (sensor histidine-30 0 segregation and condensation protein B-08 0.03 adenylylsulfate reductase; subunit B [EC:1.8.99.2]-08 0.01 transcriptional repressor NrdR-08 0.03 uroporphyrinogen decarboxylase [EC:4.1.1.37]-30 0.01 multicomponent Na+:H+ antiporter subunit D-01 0.01 GntR family transcriptional regulator-08 0.02 large subunit ribosomal protein L24-08 0.02 beta-carotene hydroxylase [EC:1.14.13.-]-08 0 ribosomal RNA large subunit methyltransferase L [EC:2.1.1.52]-30 0 arsenate reductase [EC:1.20.4.1]-08 0.01 23S ribosomal RNA-08 0.02 diphosphomevalonate decarboxylase [EC:4.1.1.33]-08 0.01 NADH dehydrogenase I subunit D [EC:1.6.5.3]-01 0.02 apolipoprotein N-acyltransferase [EC:2.3.1.-]-30 0 cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]-30 0.01 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]-01 0.02 dihydropteroate synthase [EC:2.5.1.15]-30 0.01 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4]-30 0 stearoyl-CoA desaturase (delta-9 desaturase) [EC:1.14.19.1]-30 0 DNA topoisomerase VI subunit B [EC:5.99.1.3]-08 0 electron transfer flavoprotein alpha subunit-30 0.01 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase-01 0.02 tryptophan 2;3-dioxygenase [EC:1.13.11.11]-08 0.02 diaminohydroxyphosphoribosylaminopyrimidine deaminase /-01 0.02 polycomb protein EED-30 0.01 acyl-CoA dehydrogenase [EC:1.3.99.-]-08 0.01 ATP-binding cassette; subfamily B; bacterial MsbA [EC:3.6.3.-]-01 0.03 propionyl-CoA synthetase [EC:6.2.1.17]-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 625 of 848

nucleoside-diphosphate kinase [EC:2.7.4.6]-30 0 [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]-30 0.01 glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]-08 0.01 sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2]-01 0.01 glutathione reductase (NADPH) [EC:1.8.1.7]-01 0.02 histidyl-tRNA synthetase [EC:6.1.1.21]-30 0.01 formate dehydrogenase; gamma subunit [EC:1.2.1.2]-08 0.01 ubiquinone biosynthesis monooxygenase Coq7 [EC:1.14.13.-]-08 0.01 2;3;4;5-tetrahydropyridine-2-carboxylate N-succinyltransferase-01 0.02 fumarate hydratase; class I [EC:4.2.1.2]-30 0 beta-galactosidase [EC:3.2.1.23]-30For Peer Review Only 0 alanine or glycine:cation symporter; AGCS family-01 0.02 tyrosyl-tRNA synthetase [EC:6.1.1.1]-30 0.01 Fur family transcriptional regulator; ferric uptake regulator-30 0 cobaltochelatase CobN [EC:6.6.1.2]-30 0.01 two-component system; OmpR family; sensor histidine kinase PhoQ-08 0.01 UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]-30 0.01 dihydroorotate oxidase [EC:1.3.3.1]-30 0.01 two-component system; OmpR family; response regulator RpaA-08 0 oligopeptidase A [EC:3.4.24.70]-30 0.01 acetyl-CoA carboxylase carboxyl transferase subunit beta-01 0.02 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate-30 0 ribosomal large subunit pseudouridine synthase F [EC:5.4.99.12]-08 0.01 cobyrinic acid a;c-diamide synthase [EC:6.3.5.9 6.3.1.-]-08 0.02 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5]-08 0.01 N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]-30 0.01 alanine racemase [EC:5.1.1.1]-30 0 sugar stimulation protein A-08 0.02 Rrf2 family transcriptional regulator; iron-sulfur cluster assembly-08 0.02 oxygen-independent coproporphyrinogen III oxidase [EC:1.3.99.22]-01 0.01 transcription elongation factor GreA-30 0 TatD DNase family protein [EC:3.1.21.-]-01 0.02 YggT family protein-08 0.02 chemotaxis protein MotA-08 0.02 dimethyladenosine transferase [EC:2.1.1.-]-30 0.01 large subunit ribosomal protein L6-08 0.03 elongation factor EF-Ts-01 0.02 putative transcriptional regulator-30 0.01 cell division protein FtsA-01 0.03 colicin import membrane protein-08 0.01 Hit-like protein involved in cell-cycle regulation-08 0.02 acetyl-CoA acyltransferase [EC:2.3.1.16]-08 0.02 thiol:disulfide interchange protein DsbD [EC:1.8.1.8]-01 0.01 stringent starvation protein B-08 0.01 intracellular multiplication protein IcmE-30 0 ATP-dependent Clp protease; protease subunit [EC:3.4.21.92]-01 0.02 asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 626 of 848

cell division protein ZipA-08 0.01 glutamate racemase [EC:5.1.1.3]-30 0.01 flagellar biosynthetic protein FlhB-08 0.02 bifunctional aspartokinase/homoserine dehydrogenase 1 [EC:2.7.2.4-30 0.01 pyrimidine operon attenuation protein / uracil-08 0.01 glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]-08 0.02 DNA mismatch repair protein MutL-01 0.01 type III pantothenate kinase [EC:2.7.1.33]-08 0.03 omega-6 fatty acid desaturase (delta-12 desaturase) [EC:1.14.19.-]-08 0.01 ornithine decarboxylase [EC:4.1.1.17]-01 0.02 cytidine deaminase For[EC:3.5.4.5]-08 Peer Review Only0.01 nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]-08 0.02 molybdenum cofactor biosynthesis protein A-30 0 general secretion pathway protein K-08 0.01 imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]-08 0.03 type VI secretion system protein VasG-08 0.01 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]-30 0 signal peptidase I [EC:3.4.21.89]-30 0 two-component system; OmpR family; sensor histidine kinase NblS-08 0 succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]-01 0.03 heat shock 70kDa protein 1/8-30 0.01 DNA polymerase II large subunit [EC:2.7.7.7]-08 0 integration host factor subunit beta-08 0.01 diaminohydroxyphosphoribosylaminopyrimidine deaminase /-30 0 1;4-alpha-glucan branching enzyme [EC:2.4.1.18]-30 0 glutamate dehydrogenase [EC:1.4.1.2]-01 0.01 small subunit ribosomal protein S3-01 0.02 betaine-aldehyde dehydrogenase [EC:1.2.1.8]-01 0.01 outer membrane channel protein TolC-01 0.02 glucose inhibited division protein B [EC:2.1.-.-]-30 0 exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]-30 0 dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]-08 0.01 preprotein translocase subunit SecE-08 0.02 fructose-bisphosphate aldolase; class II [EC:4.1.2.13]-01 0.01 ribosomal small subunit pseudouridine synthase A [EC:5.4.99.12]-08 0.01 carbon-monoxide dehydrogenase small subunit [EC:1.2.99.2]-08 0.01 glycyl-tRNA synthetase [EC:6.1.1.14]-01 0.01 sucrose phosphorylase [EC:2.4.1.7]-30 0 putative transposase-30 0 ribosome biogenesis GTPase [EC:3.6.1.-]-01 0.01 cytochrome c peroxidase [EC:1.11.1.5]-30 0 two-component system; OmpR family; clock-associated histidine kinase-08 0 phosphate transport system ATP-binding protein [EC:3.6.3.27]-08 0.01 ATP-binding protein involved in chromosome partitioning-01 0.02 ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]-08 0.01 ornithine--oxo-acid transaminase [EC:2.6.1.13]-08 0.01 molybdopterin biosynthesis protein MoeA-01 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 627 of 848

queuine tRNA-ribosyltransferase [EC:2.4.2.29]-01 0.03 precorrin-6X reductase [EC:1.3.1.54]-08 0.01 acetoacetyl-CoA synthetase [EC:6.2.1.16]-01 0.03 tenascin-30 0.01 citrate lyase subunit beta [EC:4.1.3.6]-08 0.02 sarcosine oxidase [EC:1.5.3.1]-08 0 serine protein kinase-30 0 quinolinate synthase [EC:2.5.1.72]-01 0.02 methionyl-tRNA formyltransferase [EC:2.1.2.9]-01 0.03 ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.2]-30 0 ribosomal RNA largeFor subunit methyltransferase Peer NReview [EC:2.1.1.-]-01 Only0.02 cobalt/nickel transport system permease protein-08 0 cytochrome c-type biogenesis protein-08 0.01 flagellar basal-body rod protein FlgG-08 0.02 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-08 0.01 exodeoxyribonuclease III [EC:3.1.11.2]-01 0.02 alanine dehydrogenase [EC:1.4.1.1]-30 0.01 glucose inhibited division protein Gid-08 0.01 lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]-30 0 UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]-30 0 high-affinity choline transport protein-30 0 thiamine biosynthesis lipoprotein-30 0 DNA repair protein RecO (recombination protein O)-08 0.02 cobaltochelatase CobT [EC:6.6.1.2]-30 0 RNA polymerase sigma-32 factor-01 0.02 regulatory protein-08 0.01 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.-.-.-]-01 0.03 polar amino acid transport system ATP-binding protein [EC:3.6.3.21]-08 0.02 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase-30 0 heme oxygenase [EC:1.14.99.3]-08 0 N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]-01 0.03 lipoprotein-releasing system permease protein-01 0.02 two-component system; NarL family; sensor histidine kinase BarA-30 0 glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]-08 0 capsular polysaccharide transport system permease protein-08 0.01 dihydroxyacetone kinase [EC:2.7.1.29]-08 0 GTP-binding protein HflX-01 0.02 FMN-dependent NADH-azoreductase [EC:1.7.-.-]-08 0.01 p-hydroxybenzoate 3-monooxygenase [EC:1.14.13.2]-08 0.01 4-hydroxybenzoate octaprenyltransferase [EC:2.5.1.-]-30 0 GTP pyrophosphokinase [EC:2.7.6.5]-01 0.01 two component system; response regulator FlrC-08 0.02 large subunit ribosomal protein L18-08 0.02 biopolymer transport protein TolR-08 0.01 dGTPase [EC:3.1.5.1]-01 0.02 cobaltochelatase CobN [EC:6.6.1.2]-01 0.01 ATP-binding cassette; sub-family F; member 3-01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 628 of 848

simple sugar transport system permease protein-30 0.01 large subunit ribosomal protein L5-01 0.01 transaldolase [EC:2.2.1.2]-01 0.02 glycine C-acetyltransferase [EC:2.3.1.29]-01 0.01 betaine/carnitine transporter; BCCT family-08 0.01 phosphotransferase system; enzyme I; PtsI [EC:2.7.3.9]-08 0.01 aromatic-amino-acid transaminase [EC:2.6.1.57]-08 0.01 protein phosphatase 1; catalytic subunit [EC:3.1.3.16]-08 0.01 undecaprenyl-diphosphatase [EC:3.6.1.27]-30 0 peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]-01 0.02 2-dehydro-3-deoxyphosphooctonateFor Peer aldolase (KDO Review 8-P synthase)-01 Only0.02 thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]-08 0.02 flagellar motor switch protein FliG-30 0 flotillin-08 0 two-component system; OmpR family; phosphate regulon sensor-30 0 membrane-bound lytic murein transglycosylase D [EC:3.2.1.-]-01 0.01 antibiotic transport system ATP-binding protein-01 0.02 putative hemolysin-08 0 phosphomethylpyrimidine kinase [EC:2.7.4.7]-30 0 [protein-PII] uridylyltransferase [EC:2.7.7.59]-01 0.01 ESCRT-II complex subunit VPS22-30 0.01 aspartoacylase [EC:3.5.1.15]-08 0 chorismate mutase [EC:5.4.99.5]-08 0.01 ribosomal RNA small subunit methyltransferase C [EC:2.1.1.52]-08 0.01 putative MFS transporter; AGZA family; xanthine/uracil permease-01 0.02 FKBP12-rapamycin complex-associated protein-08 0.01 two-component system; OmpR family; response regulator CpxR-08 0.01 voltage-gated sodium channel-08 0.01 choline dehydrogenase [EC:1.1.99.1]-01 0.02 DNA polymerase epsilon subunit 1 [EC:2.7.7.7]-08 0 cysteine desulfurase [EC:2.8.1.7]-01 0.01 multicomponent Na+:H+ antiporter subunit G-08 0.01 NADH dehydrogenase I subunit H [EC:1.6.5.3]-01 0.02 fructuronate reductase [EC:1.1.1.57]-08 0 glycine oxidase [EC:1.4.3.19]-08 0.01 ribonuclease III [EC:3.1.26.3]-30 0 [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]-01 0.02 large subunit ribosomal protein L17-08 0.02 large subunit ribosomal protein L15-08 0.03 3;4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]-01 0.03 phosphoribosyl-ATP pyrophosphohydrolase [EC:3.6.1.31]-08 0.01 monovalent cation:H+ antiporter; CPA1 family-08 0.01 pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]-30 0.01 RNA polymerase sigma-54 factor-30 0.01 ubiquinol-cytochrome c reductase cytochrome b subunit [EC:1.10.2.2]-01 0.02 cytochrome c oxidase subunit XI assembly protein-30 0 pyridoxine 5-phosphate synthase [EC:2.6.99.2]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 629 of 848

cysteine synthase A [EC:2.5.1.47]-01 0.02 protease IV [EC:3.4.21.-]-30 0 hydroxyacylglutathione hydrolase [EC:3.1.2.6]-30 0 leucine dehydrogenase [EC:1.4.1.9]-08 0.01 membrane protease subunit HflC [EC:3.4.-.-]-01 0.02 peptidyl-prolyl cis-trans isomerase C [EC:5.2.1.8]-08 0.01 chromosome partitioning protein; ParB family-01 0.02 PhoH-like ATPase-30 0 flagellar hook-associated protein 2-08 0.01 S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:5.-.-.-]-01 0.01 Icc protein-08 For Peer Review Only0.01 cyclase HisF [EC:4.1.3.-]-30 0 phycoerythrin beta chain-08 0 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate-08 0.02 phosphatidylglycerol:prolipoprotein diacylglycerol transferase-30 0 general secretion pathway protein D-30 0 putative protein-08 0.01 pre-mRNA-splicing helicase BRR2 [EC:3.6.1.-]-08 0.01 acetyl-CoA carboxylase carboxyl transferase subunit alpha-01 0.03 DnaA-homolog protein-08 0.01 TetR/AcrR family transcriptional regulator-30 0 glutamate 5-kinase [EC:2.7.2.11]-01 0.03 putrescine transport system permease protein-01 0.01 adenosine deaminase [EC:3.5.4.4]-01 0.01 molecular chaperone Hsp33-30 0 methylisocitrate lyase [EC:4.1.3.30]-30 0 tRNA pseudouridine synthase D [EC:5.4.99.12]-08 0.01 curli production assembly/transport component CsgG-01 0.01 glucokinase [EC:2.7.1.2]-08 0.02 acyl-CoA thioesterase II [EC:3.1.2.-]-08 0.01 Ca2+:H+ antiporter-08 0 NADH dehydrogenase I subunit H [EC:1.6.5.3]-30 0 DnaJ like chaperone protein-30 0 xanthine phosphoribosyltransferase [EC:2.4.2.22]-08 0.01 transcriptional repressor NrdR-30 0 cobalamin biosynthesis protein CobW-08 0.02 coatomer protein complex; subunit alpha (xenin)-30 0.01 tRNA dimethylallyltransferase [EC:2.5.1.75]-01 0.02 MFS transporter; DHA1 family; bicyclomycin/chloramphenicol-30 0 small subunit ribosomal protein S13-30 0.01 homoserine kinase type II [EC:2.7.1.39]-01 0.01 septum formation protein-30 0 oxaloacetate decarboxylase; alpha subunit [EC:4.1.1.3]-01 0.01 type IV pilus assembly protein PilQ-08 0.01 photosystem c550-30 0.01 threonine aldolase [EC:4.1.2.5]-01 0.02 acetate kinase [EC:2.7.2.1]-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 630 of 848

chorismate--pyruvate lyase [EC:4.1.3.40]-08 0.01 coproporphyrinogen III oxidase [EC:1.3.3.3]-01 0.02 phycoerythrin alpha chain-08 0 cation transport protein ChaC-08 0.01 large subunit ribosomal protein L2-01 0.03 DNA polymerase V [EC:3.4.21.-]-08 0.01 NADPH2:quinone reductase [EC:1.6.5.5]-30 0.01 holliday junction DNA helicase RuvB-30 0 heat shock protein HspQ-08 0.01 3D-(3;5/4)-trihydroxycyclohexane-1;2-dione hydrolase [EC:3.7.1.-]-01 0.02 ornithine carbamoyltransferaseFor [EC:2.1.3.3]-08Peer Review Only0.01 aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]-08 0.01 Na+:H+ antiporter; NhaB family-08 0.02 UDP-N-acetylmuramate dehydrogenase [EC:1.1.1.158]-30 0 aldose 1-epimerase [EC:5.1.3.3]-08 0.02 protein PsiE-08 0.01 O-succinylhomoserine sulfhydrylase [EC:2.5.1.-]-01 0.01 ribonuclease G [EC:3.1.26.-]-01 0.01 DNA polymerase epsilon subunit 1 [EC:2.7.7.7]-30 0.01 septum site-determining protein MinD-08 0 flagellar hook-associated protein 3 FlgL-08 0.01 selenocysteine-specific elongation factor-08 0 intracellular multiplication protein IcmE-08 0 3-dehydroquinate dehydratase II [EC:4.2.1.10]-08 0.02 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49]-30 0.01 cation efflux system protein; CDF family-08 0 uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23]-08 0 2-dehydro-3-deoxyphosphogluconate aldolase /-30 0 acetyl-CoA carboxylase biotin carboxyl carrier protein-30 0 quinolinate synthase [EC:2.5.1.72]-30 0.01 2;4-dihydroxyhept-2-ene-1;7-dioic acid aldolase [EC:4.1.2.-]-08 0.01 high-affinity choline transport protein-08 0.01 repressor LexA [EC:3.4.21.88]-30 0 cyclohexanone monooxygenase [EC:1.14.13.22]-08 0 cytochrome bd-I oxidase subunit I [EC:1.10.3.-]-30 0 phospholipid-translocating ATPase [EC:3.6.3.1]-08 0 uroporphyrinogen-III synthase [EC:4.2.1.75]-30 0 homoserine O-acetyltransferase [EC:2.3.1.31]-30 0 rhamnose transport system permease protein-08 0 thiamine transport system ATP-binding protein-08 0.01 D-xylose transport system ATP-binding protein [EC:3.6.3.17]-08 0.01 Fur family transcriptional regulator; zinc uptake regulator-08 0.01 shikimate dehydrogenase [EC:1.1.1.25]-30 0 SecD/SecF fusion protein-01 0.01 ribose transport system substrate-binding protein-08 0.01 F-type H+-transporting ATPase subunit b [EC:3.6.3.14]-01 0.02 glutamate synthase (ferredoxin) [EC:1.4.7.1]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 631 of 848

5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]-30 0 hydroxymethylbilane synthase [EC:2.5.1.61]-01 0.03 GTP-binding protein Era-01 0.01 gluconolactonase [EC:3.1.1.17]-08 0.01 taurine-pyruvate aminotransferase [EC:2.6.1.77]-08 0.01 tubulin alpha-30 0.01 Na+:H+ antiporter; NhaA family-30 0 phosphomannomutase [EC:5.4.2.8]-01 0.02 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase-30 0 tRNA pseudouridine synthase B [EC:5.4.99.12]-30 0.01 flagellar basal-body Forrod protein FlgF-08Peer Review Only0.01 sn-glycerol 3-phosphate transport system permease protein-01 0.01 rod shape-determining protein MreC-30 0 dihydroorotate oxidase [EC:1.3.3.1]-01 0.02 segregation and condensation protein A-01 0.01 glycosyl transferase; family 25-30 0.01 maltose/maltodextrin transport system ATP-binding protein-08 0.01 oligopeptidase A [EC:3.4.24.70]-01 0.01 lycopene beta cyclase [EC:1.14.-.-]-01 0.02 D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4]-08 0.02 cobalt/nickel transport system ATP-binding protein-08 0.01 minichromosome maintenance protein 4 (cell division control protein-08 0 imidazolonepropionase [EC:3.5.2.7]-01 0.01 xanthine dehydrogenase large subunit [EC:1.17.1.4]-30 0.01 acetylornithine deacetylase [EC:3.5.1.16]-30 0 endonuclease III [EC:4.2.99.18]-01 0.02 nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]-30 0 ribulose-phosphate 3-epimerase [EC:5.1.3.1]-01 0.02 lysozyme [EC:3.2.1.17]-08 0 diaminopimelate epimerase [EC:5.1.1.7]-01 0.02 pyrroline-5-carboxylate reductase [EC:1.5.1.2]-30 0.01 geranyl-CoA carboxylase alpha subunit [EC:6.4.1.5]-08 0.01 8-amino-7-oxononanoate synthase [EC:2.3.1.47]-08 0.01 V-type H+-transporting ATPase subunit A [EC:3.6.3.14]-08 0 hypothetical chaperone protein-08 0.01 lipid A biosynthesis lauroyl acyltransferase [EC:2.3.1.-]-30 0 iduronate 2-sulfatase [EC:3.1.6.13]-08 0 sulfate adenylyltransferase subunit 1 [EC:2.7.7.4]-30 0 putative lipoprotein-01 0.02 fructose-1;6-bisphosphatase I [EC:3.1.3.11]-30 0.01 CBS domain-containing protein-08 0.01 para-aminobenzoate synthetase component I [EC:2.6.1.85]-30 0 undecaprenyl diphosphate synthase [EC:2.5.1.31]-08 0.03 ubiquinone/menaquinone biosynthesis methyltransferase [EC:2.1.1.-]-01 0.02 MFS transporter; BCD family; chlorophyll transporter-08 0 integrase/recombinase XerC-30 0 fructose-1;6-bisphosphatase II / sedoheptulose-1;7-bisphosphatase-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 632 of 848

flagellin-01 0.01 benzoate-CoA ligase [EC:6.2.1.25]-08 0.01 choline-sulfatase [EC:3.1.6.6]-08 0.01 arginine decarboxylase [EC:4.1.1.19]-30 0 SsrA-binding protein-08 0.03 DNA-directed RNA polymerase III subunit C1 [EC:2.7.7.6]-30 0.01 zinc protease [EC:3.4.99.-]-01 0.01 exodeoxyribonuclease V beta subunit [EC:3.1.11.5]-30 0 small subunit ribosomal protein S8-08 0.03 isocitrate dehydrogenase kinase/phosphatase [EC:2.7.11.5 3.1.3.-]-01 0.01 cytochrome c oxidaseFor subunit XV Peer assembly protein-30 Review Only0.01 peptidyl-tRNA hydrolase; PTH1 family [EC:3.1.1.29]-30 0 3-dehydroquinate synthase [EC:4.2.3.4]-01 0.02 putative tricarboxylic transport membrane protein-30 0 small subunit ribosomal protein S9-08 0.02 alpha-glucosidase [EC:3.2.1.20]-08 0.01 alkylated DNA repair protein [EC:1.14.11.-]-08 0.01 DNA topoisomerase II [EC:5.99.1.3]-30 0.01 general secretion pathway protein G-08 0.01 zinc transport system permease protein-01 0.01 translation initiation factor IF-3-01 0.02 LysR family transcriptional regulator; hydrogen peroxide-inducible-30 0 N-carbamoylputrescine amidase [EC:3.5.1.53]-08 0.01 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]-08 0.02 homoserine kinase type II [EC:2.7.1.39]-08 0.01 peptide chain release factor eRF subunit 1-08 0 urease alpha subunit [EC:3.5.1.5]-30 0 protein-L-isoaspartate(D-aspartate) O-methyltransferase-30 0 tRNA pseudouridine synthase A [EC:5.4.99.12]-01 0.02 competence protein ComEC-30 0 aquaporin Z-08 0.01 nicotinate-nucleotide pyrophosphorylase (carboxylating)-01 0.02 dTDP-4-dehydrorhamnose 3;5-epimerase [EC:5.1.3.13]-08 0.02 two-component system; chemotaxis family; response regulator CheB-08 0.01 putative biotin biosynthesis protein BioY-08 0.02 4-hydroxybenzoate octaprenyltransferase [EC:2.5.1.-]-01 0.02 peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]-08 0.02 glutamate dehydrogenase (NADP+) [EC:1.4.1.4]-08 0.01 methylthioribose-1-phosphate isomerase [EC:5.3.1.23]-30 0 pyruvate; water dikinase [EC:2.7.9.2]-08 0.01 membrane protease subunit HflK [EC:3.4.-.-]-01 0.03 16S ribosomal RNA-08 0.01 membrane-bound lytic murein transglycosylase C [EC:3.2.1.-]-08 0.01 methionyl aminopeptidase [EC:3.4.11.18]-01 0.02 type VI secretion system protein ImpL-08 0 GntR family transcriptional regulator / MocR family aminotransferase-01 0.01 thiol:disulfide interchange protein DsbA-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 633 of 848

UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]-01 0.02 non-specific serine/threonine protein kinase [EC:2.7.11.1]-08 0 ATP-dependent helicase HepA [EC:3.6.1.-]-08 0.01 large subunit ribosomal protein L7/L12-30 0.01 thiamine biosynthesis protein ThiC-30 0.01 2-methylcitrate dehydratase [EC:4.2.1.79]-30 0 folylpolyglutamate synthase [EC:6.3.2.17]-08 0.01 beta-hexosaminidase [EC:3.2.1.52]-01 0.01 glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]-08 0.03 N-acetylneuraminate synthase [EC:2.5.1.56]-01 0.02 glycerol-3-phosphateFor dehydrogenase Peer (NAD(P)+) [EC:1.1.1.94]-01Review Only0.03 hydroxypyruvate reductase [EC:1.1.1.81]-08 0.01 dimethyladenosine transferase [EC:2.1.1.-]-01 0.02 argininosuccinate synthase [EC:6.3.4.5]-30 0.01 DNA-directed RNA polymerase subunit B [EC:2.7.7.6]-08 0 phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2]-08 0.01 anhydro-N-acetylmuramic acid kinase [EC:2.7.1.-]-01 0.02 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase)-01 0.02 tRNA(Ile)-lysidine synthase [EC:6.3.4.-]-30 0 adenosylcobinamide-phosphate synthase CobD [EC:6.3.1.10]-30 0 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit-30 0 chloramphenicol-sensitive protein RarD-01 0.02 non-specific serine/threonine protein kinase [EC:2.7.11.1]-30 0 sucrose-phosphate synthase [EC:2.4.1.14]-08 0 small subunit ribosomal protein S11-08 0.02 biotin synthetase [EC:2.8.1.6]-30 0 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]-01 0.02 pre-mRNA-processing factor 8-30 0.01 pantoate ligase / cytidylate kinase [EC:6.3.2.1 2.7.4.14]-08 0 dihydropteroate synthase [EC:2.5.1.15]-01 0.02 tRNA(Ile)-lysidine synthase [EC:6.3.4.-]-01 0.03 citryl-CoA lyase [EC:4.1.3.34]-08 0.01 sulfonate/nitrate/taurine transport system permease protein-30 0.01 small subunit ribosomal protein S2-01 0.02 charged multivesicular body protein 6-30 0 tRNA (guanine-N1-)-methyltransferase [EC:2.1.1.31]-01 0.02 UDP-D-GlcNAcA oxidase [EC:1.1.1.-]-08 0.01 cysteine synthase B [EC:2.5.1.47]-01 0.01 ribulose-bisphosphate carboxylase small chain [EC:4.1.1.39]-30 0.01 cob(I)alamin adenosyltransferase [EC:2.5.1.17]-30 0 CyaY protein-08 0.01 NADH dehydrogenase I subunit C [EC:1.6.5.3]-08 0.02 chlorophyll a/b binding light-harvesting protein PcbD-08 0 fumarate hydratase; class I [EC:4.2.1.2]-01 0.01 endonuclease III [EC:4.2.99.18]-30 0.01 diaminopropionate ammonia-lyase [EC:4.3.1.15]-01 0.02 acetoacetyl-CoA reductase [EC:1.1.1.36]-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 634 of 848

D-alanine transaminase [EC:2.6.1.21]-08 0.02 2-dehydro-3-deoxyphosphogluconate aldolase /-08 0.02 phosphoheptose isomerase [EC:5.-.-.-]-08 0.01 glucosylglycerol-phosphate synthase [EC:2.4.1.213]-08 0 glycyl-tRNA synthetase [EC:6.1.1.14]-30 0.01 large subunit ribosomal protein L31-08 0.02 adenylylsulfate kinase [EC:2.7.1.25]-30 0 alpha-L-fucosidase [EC:3.2.1.51]-08 0 tRNA-dihydrouridine synthase A [EC:1.-.-.-]-01 0.02 geranylgeranyl diphosphate synthase; type I [EC:2.5.1.1 2.5.1.10-08 0.01 uroporphyrin-III C-methyltransferaseFor Peer [EC:2.1.1.107]-08 Review Only0.02 ATP-dependent helicase HrpB [EC:3.6.1.-]-30 0.01 prephenate dehydratase [EC:4.2.1.51]-01 0.03 phosphonate transport system ATP-binding protein-08 0.01 glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]-30 0 adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]-08 0.02 riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]-01 0.02 septum site-determining protein MinC-08 0 nitronate monooxygenase [EC:1.13.12.16]-08 0.02 5-methylthioribose kinase [EC:2.7.1.100]-08 0 ureidoglycolate hydrolase [EC:3.5.3.19]-08 0.01 integration host factor subunit alpha-08 0.01 phosphatidylcholine synthase [EC:2.7.8.24]-08 0.01 5-methyltetrahydropteroyltriglutamate--homocysteine-30 0.01 small subunit ribosomal protein S7-30 0.01 large subunit ribosomal protein L14-30 0.01 adenylate kinase [EC:2.7.4.3]-30 0.01 Na+-transporting NADH:ubiquinone oxidoreductase subunit B-30 0 mannitol 2-dehydrogenase [EC:1.1.1.67]-08 0.01 deoxyhypusine synthase [EC:2.5.1.46]-01 0.02 type III pantothenate kinase [EC:2.7.1.33]-30 0 translation initiation factor IF-1-08 0.02 tRNA-dihydrouridine synthase C [EC:1.-.-.-]-08 0.01 xanthine dehydrogenase small subunit [EC:1.17.1.4]-30 0 type IV pilus assembly protein PilQ-30 0 xanthine dehydrogenase accessory factor-30 0 chlorophyllide reductase subunit Z [EC:1.18.-.-]-08 0 D-alanine-D-alanine ligase [EC:6.3.2.4]-30 0 photosystem I subunit III-30 0.01 molecular chaperone GrpE-01 0.02 intestinal mucin-2-08 0 putative translation factor-01 0.02 protoporphyrinogen oxidase [EC:1.3.3.4]-08 0.02 2;4-dihydroxyhept-2-ene-1;7-dioic acid aldolase [EC:4.1.2.-]-01 0 iron complex outermembrane recepter protein-01 0.01 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)-01 0.02 4-carboxymuconolactone decarboxylase [EC:4.1.1.44]-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 635 of 848

glycine cleavage system H protein-30 0 cell division transport system ATP-binding protein-08 0.02 Notch-08 0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD [EC:4.1.1.-]-30 0 O-succinylbenzoate synthase [EC:4.2.1.113]-08 0 large subunit ribosomal protein L25-01 0.02 large subunit ribosomal protein L10-30 0 ribonuclease HI [EC:3.1.26.4]-08 0.03 multicomponent Na+:H+ antiporter subunit F-08 0.01 CysQ protein-30 0 MFS transporter; FHSFor family; L-fucose Peer permease-30 Review Only 0 UDP-glucose 4-epimerase [EC:5.1.3.2]-01 0.02 methylated-DNA-protein-cysteine methyltransferase related protein-08 0.01 FO synthase [EC:2.5.1.-]-08 0.01 undecaprenyl diphosphate synthase [EC:2.5.1.31]-01 0.02 photosystem I subunit XI-30 0.01 high-affinity iron transporter-30 0 small subunit ribosomal protein S11-30 0.01 fatty-acyl-CoA synthase [EC:6.2.1.-]-01 0.02 dCTP deaminase [EC:3.5.4.13]-30 0 carboxylesterase type B [EC:3.1.1.1]-08 0.01 DNA-directed RNA polymerase III subunit C1 [EC:2.7.7.6]-08 0 small subunit ribosomal protein S19-08 0.01 tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]-01 0.02 glycine betaine/proline transport system ATP-binding protein-30 0.01 preprotein translocase subunit YajC-08 0.01 lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]-01 0.02 putative N6-adenine-specific DNA methylase-08 0.01 GTP pyrophosphokinase [EC:2.7.6.5]-30 0.01 triacylglycerol lipase [EC:3.1.1.3]-08 0 Na+-transporting NADH:ubiquinone oxidoreductase subunit D-30 0 E3 ubiquitin-protein ligase HERC2 [EC:6.3.2.19]-30 0 simple sugar transport system substrate-binding protein-30 0 NADH dehydrogenase I subunit I [EC:1.6.5.3]-30 0 ATP-dependent Clp protease adaptor protein ClpS-08 0.01 Ca2+-transporting ATPase [EC:3.6.3.8]-08 0 NAD(P) transhydrogenase [EC:1.6.1.1]-30 0 fructose-bisphosphate aldolase; class II [EC:4.1.2.13]-30 0.01 phosphate acetyltransferase [EC:2.3.1.8]-30 0 pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]-30 0 elongation factor EF-2 [EC:3.6.5.3]-30 0.01 stage II sporulation protein D-08 0 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase /-01 0.01 adenosylmethionine-8-amino-7-oxononanoate aminotransferase-01 0.01 3-demethylubiquinone-9 3-methyltransferase [EC:2.1.1.- 2.1.1.64]-30 0 ferredoxin--NADP+ reductase [EC:1.18.1.2]-30 0.01 cytochrome b6-f complex subunit 4-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 636 of 848

putative thiamine transport system substrate-binding protein-08 0.01 F-type H+-transporting ATPase subunit b [EC:3.6.3.14]-30 0.01 CysQ protein-01 0.02 lipopolysaccharide export system permease protein-01 0.03 competence/damage-inducible protein CinA-30 0 dihydropyrimidinase [EC:3.5.2.2]-30 0 flagellar hook protein FlgE-30 0 exonuclease SbcC-01 0.01 glycine cleavage system H protein-08 0.02 solute:Na+ symporter; SSS family-01 0.01 peptidyl-dipeptidaseFor A [EC:3.4.15.1]-30 Peer Review Only 0 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase-30 0.01 asparaginyl-tRNA synthetase [EC:6.1.1.22]-30 0.01 glucose inhibited division protein B [EC:2.1.-.-]-08 0.03 exodeoxyribonuclease I [EC:3.1.11.1]-30 0 ribonuclease Z [EC:3.1.26.11]-08 0.01 dephospho-CoA kinase [EC:2.7.1.24]-30 0 oxaloacetate decarboxylase; beta subunit [EC:4.1.1.3]-01 0.01 molybdenum cofactor biosynthesis protein A-01 0.02 elongation factor EF-P-01 0.02 succinate-semialdehyde dehydrogenase (NADP+) [EC:1.2.1.16]-01 0.02 DNA-3-methyladenine glycosylase II [EC:3.2.2.21]-08 0.01 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]-01 0.02 putative spermidine/putrescine transport system ATP-binding protein-30 0 succinate dehydrogenase iron-sulfur protein [EC:1.3.99.1]-01 0.02 ribosomal protein S6 modification protein-30 0 ribosomal protein L11 methyltransferase [EC:2.1.1.-]-30 0 phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]-08 0.02 xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2]-08 0 transcription elongation factor SPT6-30 0.01 flagellar biosynthesis protein FlhF-08 0.01 plastocyanin-08 0 two-component system; OmpR family; response regulator-30 0 zinc transport system substrate-binding protein-01 0.01 phosphate transport system substrate-binding protein-30 0 triosephosphate isomerase (TIM) [EC:5.3.1.1]-30 0.01 small subunit ribosomal protein S13-08 0.03 GST-like protein-30 0 hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88]-08 0.01 glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]-30 0.01 undecaprenyl diphosphate synthase [EC:2.5.1.31]-30 0 UDP-N-acetylmuramate dehydrogenase [EC:1.1.1.158]-01 0.02 RNA polymerase sigma factor for flagellar operon FliA-30 0 integrator complex subunit 6-08 0 cobaltochelatase CobS [EC:6.6.1.2]-30 0 riboflavin synthase alpha chain [EC:2.5.1.9]-30 0 aminopeptidase [EC:3.4.11.-]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 637 of 848

type IV pilus assembly protein PilB-30 0 alpha 1;3-glucosidase [EC:3.2.1.84]-08 0 ubiquinone/menaquinone biosynthesis methyltransferase [EC:2.1.1.-]-30 0 2-C-methyl-D-erythritol 2;4-cyclodiphosphate synthase [EC:4.6.1.12]-08 0.01 CarD family transcriptional regulator-01 0.01 thiamine biosynthesis protein ThiC-01 0.01 two-component system; NtrC family; nitrogen regulation response-01 0.02 glycine dehydrogenase subunit 2 [EC:1.4.4.2]-08 0 manganese/iron transport system substrate-binding protein-08 0.01 LL-diaminopimelate aminotransferase [EC:2.6.1.83]-08 0 NADH dehydrogenaseFor I subunit NPeer [EC:1.6.5.3]-30 Review Only0.01 sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2]-30 0 ribonuclease D [EC:3.1.13.5]-30 0 small subunit ribosomal protein S4-01 0.02 ribose transport system permease protein-08 0.01 ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]-30 0.01 zinc/manganese transport system substrate-binding protein-08 0 coniferyl-aldehyde dehydrogenase [EC:1.2.1.68]-30 0 dipeptidyl-peptidase III [EC:3.4.14.4]-08 0.01 glucose inhibited division protein B [EC:2.1.-.-]-01 0.02 biopolymer transport protein TolQ-30 0 proline iminopeptidase [EC:3.4.11.5]-30 0 cystathionine beta-lyase [EC:4.4.1.8]-01 0.02 putative glutamine amidotransferase-30 0 sec-independent protein translocase protein TatC-01 0.02 glucuronate isomerase [EC:5.3.1.12]-08 0.01 alkyl hydroperoxide reductase subunit F [EC:1.6.4.-]-30 0 DNA replication and repair protein RecF-01 0.01 oxaloacetate decarboxylase; alpha subunit [EC:4.1.1.3]-30 0 galactokinase [EC:2.7.1.6]-30 0 putative acetyltransferase [EC:2.3.1.-]-08 0.01 flagellar basal-body rod protein FlgC-08 0.01 clathrin; heavy polypeptide-08 0 basic amino acid/polyamine antiporter; APA family-08 0.01 4-alpha-glucanotransferase [EC:2.4.1.25]-30 0 AFG3 family protein [EC:3.4.24.-]-30 0.01 ribosomal RNA large subunit methyltransferase F [EC:2.1.1.48]-08 0.01 shikimate kinase [EC:2.7.1.71]-01 0.01 esterase / lipase [EC:3.1.1.-]-08 0.01 Fe-S cluster assembly ATP-binding protein-01 0.02 lipid A biosynthesis lauroyl acyltransferase [EC:2.3.1.-]-01 0.02 mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]-08 0 prephenate dehydrogenase [EC:1.3.1.12]-30 0 large subunit ribosomal protein L6-30 0 tryptophan-rich sensory protein-08 0.01 muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]-08 0.01 WNK lysine deficient protein kinase [EC:2.7.11.1]-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 638 of 848

ribose 5-phosphate isomerase B [EC:5.3.1.6]-08 0.01 anthranilate phosphoribosyltransferase [EC:2.4.2.18]-01 0.02 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]-30 0 tRNA-dihydrouridine synthase A [EC:1.-.-.-]-30 0.01 glucose-1-phosphate cytidylyltransferase [EC:2.7.7.33]-08 0.01 5-hydroxyisourate hydrolase [EC:3.5.2.17]-08 0.01 taurine dioxygenase [EC:1.14.11.17]-01 0.01 N-acylneuraminate cytidylyltransferase [EC:2.7.7.43]-08 0.01 kynureninase [EC:3.7.1.3]-30 0 integrase/recombinase XerD-30 0 beta-galactosidase [EC:3.2.1.23]-01For Peer Review Only0.01 pantoate--beta-alanine ligase [EC:6.3.2.1]-01 0.02 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4]-30 0 DNA polymerase IV [EC:2.7.7.7]-01 0.01 type VI secretion system protein ImpJ-08 0 sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]-30 0 leader peptidase (prepilin peptidase) / N-methyltransferase-08 0.02 iron complex transport system ATP-binding protein [EC:3.6.3.34]-30 0.01 biopolymer transport protein ExbD-30 0 vanillate monooxygenase [EC:1.14.13.82]-08 0.01 chemotaxis protein MotA-30 0 ribosomal RNA small subunit methyltransferase E [EC:2.1.1.-]-30 0 flagellar hook-associated protein 1 FlgK-30 0 large subunit ribosomal protein L3-01 0.02 RNA polymerase sigma-54 factor-01 0.01 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]-08 0.02 glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]-01 0.01 bifunctional protein GlmU [EC:2.7.7.23 2.3.1.157]-01 0.01 tRNA dimethylallyltransferase [EC:2.5.1.75]-30 0.01 molybdenum cofactor biosynthesis protein B-30 0 sulfate adenylyltransferase [EC:2.7.7.4]-01 0.01 N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]-30 0 fructose-1;6-bisphosphatase II [EC:3.1.3.11]-30 0 acetylglutamate kinase [EC:2.7.2.8]-01 0.02 phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]-30 0 3R-hydroxymyristoyl ACP dehydrase [EC:4.2.1.-]-30 0 3-isopropylmalate dehydratase [EC:4.2.1.33]-08 0.01 sec-independent protein translocase protein TatB-08 0.01 proton-dependent oligopeptide transporter; POT family-30 0 glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]-30 0 mannosyl-oligosaccharide alpha-1;2-mannosidase [EC:3.2.1.113]-08 0 large subunit ribosomal protein L20-08 0.03 zinc/manganese transport system ATP-binding protein-08 0 MSHA biogenesis protein MshO-08 0.01 fructose-1;6-bisphosphatase II [EC:3.1.3.11]-01 0.01 galactokinase [EC:2.7.1.6]-08 0 flagellar motor switch protein FliM-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 639 of 848

NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]-08 0 pre-mRNA-splicing helicase BRR2 [EC:3.6.1.-]-30 0.01 uridylate kinase [EC:2.7.4.22]-08 0.03 formiminoglutamase [EC:3.5.3.8]-08 0.01 shikimate dehydrogenase [EC:1.1.1.25]-01 0.02 Na+-transporting NADH:ubiquinone oxidoreductase subunit E-30 0 cathepsin X [EC:3.4.18.1]-30 0.01 peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11-08 0.01 flagellar L-ring protein precursor FlgH-08 0.01 diaminobutyrate-2-oxoglutarate transaminase [EC:2.6.1.76]-08 0 polysaccharide exportFor outer membrane Peer protein-30 Review Only 0 flagellar basal-body rod protein FlgG-30 0 F-type H+-transporting ATPase subunit delta [EC:3.6.3.14]-30 0.01 putative tricarboxylic transport membrane protein-01 0.02 putative holliday junction resolvase [EC:3.1.-.-]-08 0.02 ATP-dependent helicase STH1/SNF2 [EC:3.6.1.-]-30 0.01 MFS transporter; NNP family; nitrate/nitrite transporter-30 0.01 D-erythrose 4-phosphate dehydrogenase [EC:1.2.1.72]-08 0.01 serine protease DegS [EC:3.4.21.-]-08 0.01 octaprenyl diphosphate synthase [EC:2.5.1.-]-30 0.01 MoxR-like ATPase [EC:3.6.3.-]-01 0.01 signal peptidase I [EC:3.4.21.89]-01 0.02 5-oxoprolinase (ATP-hydrolysing) [EC:3.5.2.9]-30 0.01 putative copper resistance protein D-08 0.01 phosphoinositide-3-kinase; regulatory subunit 4; p150 [EC:2.7.11.1]-30 0.01 iron(III) transport system ATP-binding protein [EC:3.6.3.30]-30 0 Na+-transporting NADH:ubiquinone oxidoreductase subunit F-01 0.01 small subunit ribosomal protein S12-30 0.01 zeta-carotene desaturase [EC:1.14.99.30]-08 0 NAD+ kinase [EC:2.7.1.23]-01 0.02 O-succinylbenzoic acid--CoA ligase [EC:6.2.1.26]-08 0.01 large subunit ribosomal protein L11-30 0.01 glutathione synthase [EC:6.3.2.3]-01 0.02 ATP-dependent Clp protease ATP-binding subunit ClpC-01 0.01 LysR family transcriptional regulator; hydrogen peroxide-inducible-01 0.01 apocytochrome f-08 0 ribonuclease HII [EC:3.1.26.4]-01 0.02 cation efflux system protein; CDF family-30 0 ribosomal large subunit pseudouridine synthase C [EC:5.4.99.12]-30 0 glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]-01 0.02 holo-[acyl-carrier protein] synthase [EC:2.7.8.7]-08 0.01 fructokinase [EC:2.7.1.4]-08 0.03 exoribonuclease II [EC:3.1.13.1]-01 0.01 phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2]-30 0 nicotinate-nucleotide--dimethylbenzimidazole-30 0 nucleoside-triphosphatase [EC:3.6.1.15]-30 0 dCMP deaminase [EC:3.5.4.12]-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 640 of 848

lipopolysaccharide export system protein LptA-08 0.01 glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]-01 0.02 beta-N-acetylhexosaminidase [EC:3.2.1.52]-01 0.01 phage shock protein A-30 0 guanosine-3';5'-bis(diphosphate) 3'-pyrophosphohydrolase-30 0 phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]-08 0.01 preprotein translocase subunit SecF-01 0.02 xanthine dehydrogenase large subunit [EC:1.17.1.4]-01 0.01 4-coumarate--CoA ligase [EC:6.2.1.12]-08 0.01 undecaprenyl-diphosphatase [EC:3.6.1.27]-01 0.02 uridylate kinase [EC:2.7.4.22]-30For Peer Review Only 0 small subunit ribosomal protein S5-01 0.02 phosphatidylserine decarboxylase [EC:4.1.1.65]-30 0 cell division cycle 14 [EC:3.1.3.48]-30 0 cytidylate kinase [EC:2.7.4.14]-30 0 protein kinase A [EC:2.7.11.11]-08 0 DNA glycosylase [EC:3.2.2.-]-08 0 type IV pilus assembly protein PilY1-30 0 UDP-2;3-diacylglucosamine hydrolase [EC:3.6.1.-]-30 0 large subunit ribosomal protein L27-08 0.02 GAF domain-containing protein-08 0.01 protein-tyrosine phosphatase [EC:3.1.3.48]-08 0.01 pyridoxine 5-phosphate synthase [EC:2.6.99.2]-01 0.02 circadian clock protein KaiC-08 0 small subunit ribosomal protein S17-08 0.01 cell division transport system permease protein-30 0 methyltransferase [EC:2.1.1.-]-01 0.02 monofunctional biosynthetic peptidoglycan transglycosylase-08 0.01 phosphate:Na+ symporter; PNaS family-01 0.01 heat shock 70kDa protein 5-08 0 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.60]-30 0 thiamine-monophosphate kinase [EC:2.7.4.16]-01 0.02 chlorophyllide reductase subunit Y [EC:1.18.1.-]-08 0 LacI family transcriptional regulator-30 0 putative NADH dehydrogenase/NAD(P)H nitroreductase RutE [EC:1.-.-.-]-08 0 GDP-L-fucose synthase [EC:1.1.1.271]-30 0 flagellar M-ring protein FliF-30 0 ubiquitin carboxyl-terminal hydrolase 14 [EC:3.1.2.15]-08 0 thiamine biosynthesis ThiG-08 0.02 urea transport system ATP-binding protein-08 0 DNA-directed RNA polymerase I subunit A1 [EC:2.7.7.6]-30 0.01 large subunit ribosomal protein L1-01 0.02 V-type H+-transporting ATPase subunit I [EC:3.6.3.14]-08 0.01 glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]-30 0 protein phosphatase [EC:3.1.3.16]-08 0.01 type IV pilus assembly protein PilN-08 0 translation initiation factor eIF-6-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 641 of 848

tRNA (guanosine-2'-O-)-methyltransferase [EC:2.1.1.34]-08 0.01 cytochrome c-type biogenesis protein-01 0.01 photosystem II PsbE protein-30 0.01 sulfate adenylyltransferase [EC:2.7.7.4]-30 0 ubiquinol-cytochrome c reductase cytochrome c1 subunit [EC:1.10.2.2]-30 0 peptidoglycan-associated lipoprotein-08 0.02 biopolymer transport protein ExbB-01 0.01 RNA methyltransferase; TrmH family [EC:2.1.1.-]-01 0.02 putative RNA-binding protein containing KH domain-08 0.01 precorrin-8X methylmutase [EC:5.4.1.2]-08 0.01 L-2;4-diaminobutyricFor acid acetyltransferase Peer [EC:2.3.1.178]-08 Review Only0.01 small subunit ribosomal protein S19-30 0.01 poly(A) polymerase [EC:2.7.7.19]-30 0.01 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]-01 0.01 FdhD protein-30 0 GTP cyclohydrolase I [EC:3.5.4.16]-01 0.02 nitric-oxide reductase NorQ protein [EC:1.7.99.7]-08 0.01 transitional endoplasmic reticulum ATPase-30 0.01 putative ABC transport system permease protein-30 0 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16-08 0 DnaJ like chaperone protein-01 0.01 enoyl-CoA hydratase [EC:4.2.1.17]-01 0.02 small conductance mechanosensitive ion channel; MscS family-30 0 flagellar biosynthetic protein FlhB-30 0 thymidine phosphorylase [EC:2.4.2.4]-30 0 pyrroline-5-carboxylate reductase [EC:1.5.1.2]-01 0.02 small subunit ribosomal protein S10-08 0.02 poly(A) polymerase [EC:2.7.7.19]-01 0.02 DtxR family transcriptional regulator; Mn-dependent transcriptional-08 0.01 NADH dehydrogenase I subunit A [EC:1.6.5.3]-08 0.02 flap endonuclease-1 [EC:3.-.-.-]-08 0 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]-30 0 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase-01 0.02 oxalyl-CoA decarboxylase [EC:4.1.1.8]-08 0 zinc transporter; ZIP family-08 0.01 large subunit ribosomal protein L28-08 0.02 imidazolonepropionase [EC:3.5.2.7]-30 0 dihydrofolate reductase [EC:1.5.1.3]-30 0 4-hydroxybutyrate dehydrogenase [EC:1.1.1.61]-08 0.01 phosphoethanolamine transferase-01 0.01 large subunit ribosomal protein L4-08 0.03 lycopene beta cyclase [EC:1.14.-.-]-30 0 DNA polymerase III subunit delta' [EC:2.7.7.7]-01 0.02 tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]-08 0.01 iron complex transport system substrate-binding protein-30 0.01 type IV pilus assembly protein PilM-08 0.01 multicomponent Na+:H+ antiporter subunit E-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 642 of 848

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate-30 0 pseudouridylate synthase [EC:4.2.1.70]-08 0 putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]-30 0 amidase [EC:3.5.1.4]-30 0 large subunit ribosomal protein L16-01 0.01 peptidoglycan-associated lipoprotein-30 0 ferredoxin-nitrate reductase [EC:1.7.7.2]-08 0 ADP-ribosylglycohydrolase [EC:3.2.-.-]-08 0.01 glutathione synthase [EC:6.3.2.3]-30 0.01 ATP-binding cassette; sub-family E; member 1-08 0 small subunit ribosomalFor protein S3-30Peer Review Only0.01 flagellar biosynthetic protein FliR-08 0.01 uncharacterized membrane protein-30 0 two-component system; chemotaxis family; response regulator CheY-08 0 outer membrane protein OmpU-01 0.01 two component system; response regulator FlrC-30 0 Cu(I)/Ag(I) efflux system membrane protein CusB-08 0.01 sulfate adenylyltransferase subunit 1 [EC:2.7.7.4]-08 0.01 dihydroneopterin aldolase [EC:4.1.2.25]-30 0 ribokinase [EC:2.7.1.15]-30 0 GMP reductase [EC:1.7.1.7]-01 0 glutamine amidotransferase [EC:2.4.2.-]-01 0.02 dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12-30 0 citronellyl-CoA synthetase [EC:6.2.1.-]-08 0.01 adenosylmethionine-8-amino-7-oxononanoate aminotransferase-30 0 16S ribosomal RNA-30 0.01 superoxide dismutase [EC:1.15.1.1]-08 0 FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8]-08 0.01 CrcB protein-08 0.01 farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]-01 0.02 phosphatidylglycerol:prolipoprotein diacylglycerol transferase-01 0.02 GTP-binding protein Era-30 0.01 photosystem c550-08 0.01 acetolactate synthase I/III small subunit [EC:2.2.1.6]-08 0.03 aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]-08 0 uroporphyrinogen-III synthase [EC:4.2.1.75]-01 0.02 DNA-directed RNA polymerase III subunit C2 [EC:2.7.7.6]-08 0 DNA polymerase II [EC:2.7.7.7]-30 0 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.60]-01 0.01 N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]-01 0.02 glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]-01 0.01 tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.25-30 0 glucokinase [EC:2.7.1.2]-30 0 cytochrome b561-08 0 penicillin amidase [EC:3.5.1.11]-30 0 GlpG protein-08 0.01 peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 643 of 848

beta-glucosidase [EC:3.2.1.21]-01 0.01 5-methyltetrahydropteroyltriglutamate--homocysteine-01 0.01 adenylylsulfate reductase; subunit A [EC:1.8.99.2]-30 0 MFS transporter; UMF1 family-01 0.01 DNA adenine methylase [EC:2.1.1.72]-08 0 nitrilase [EC:3.5.5.1]-08 0.01 GMP reductase [EC:1.7.1.7]-30 0 monothiol glutaredoxin-08 0.01 multicomponent K+:H+ antiporter subunit A-08 0.01 ATP-dependent Clp protease ATP-binding subunit ClpB-01 0.01 alpha-glucoside transportFor system Peer substrate-binding Review protein-08 Only 0 tryptophan synthase alpha chain [EC:4.2.1.20]-01 0.02 multicomponent Na+:H+ antiporter subunit C-08 0.01 dUTP pyrophosphatase [EC:3.6.1.23]-01 0.01 ribonuclease D [EC:3.1.13.5]-01 0.01 saccharopine dehydrogenase (NAD+; L-lysine forming) [EC:1.5.1.7]-08 0.01 outer membrane lipoprotein Blc-08 0.01 phosphoglycolate phosphatase [EC:3.1.3.18]-01 0.02 serine O-acetyltransferase [EC:2.3.1.30]-30 0 monovalent cation:H+ antiporter-2; CPA2 family-30 0 mannose-6-phosphate isomerase [EC:5.3.1.8]-30 0 DNA polymerase III subunit chi [EC:2.7.7.7]-08 0.01 isoquinoline 1-oxidoreductase; beta subunit [EC:1.3.99.16]-30 0 2-oxoglutarate ferredoxin oxidoreductase subunit beta [EC:1.2.7.3]-08 0.01 elongation factor EF-1 alpha subunit [EC:3.6.5.3]-08 0 muconate cycloisomerase [EC:5.5.1.1]-08 0.01 cystathionine beta-lyase [EC:4.4.1.8]-30 0 modification methylase [EC:2.1.1.72]-30 0 CCR4-NOT transcription complex subunit 1-08 0 Cu/Zn superoxide dismutase [EC:1.15.1.1]-08 0 large subunit ribosomal protein L13-30 0 orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]-01 0.02 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6)-01 0.02 ATP-dependent helicase HrpA [EC:3.6.1.-]-01 0.01 malate dehydrogenase (decarboxylating) [EC:1.1.1.39]-08 0 two-component system; OmpR family; response regulator PhoP-08 0.01 ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]-08 0 sorbitol/mannitol transport system ATP-binding protein-08 0.01 purine nucleosidase [EC:3.2.2.1]-08 0.01 isoquinoline 1-oxidoreductase; alpha subunit [EC:1.3.99.16]-08 0.01 ubiquinone biosynthesis monooxygenase Coq7 [EC:1.14.13.-]-01 0.01 A/G-specific adenine glycosylase [EC:3.2.2.-]-30 0.01 GntR family transcriptional regulator-01 0.01 creatinine amidohydrolase [EC:3.5.2.10]-08 0 manganese/zinc/iron transport system permease protein-08 0.01 DNA mismatch repair protein MutS2-30 0 dethiobiotin synthetase [EC:6.3.3.3]-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 644 of 848

BirA family transcriptional regulator; biotin operon repressor /-30 0 iron-sulfur cluster assembly protein-08 0.01 tryptophan synthase alpha chain [EC:4.2.1.20]-30 0 multiple sugar transport system substrate-binding protein-01 0.02 two-component system; OmpR family; response regulator RstA-08 0.01 tubulin beta-30 0.01 putative spermidine/putrescine transport system substrate-binding-30 0 alkane 1-monooxygenase [EC:1.14.15.3]-08 0.01 diaminopropionate ammonia-lyase [EC:4.3.1.15]-30 0 aminobenzoyl-glutamate utilization protein B-08 0 putative SAM-dependentFor methyltransferase-30 Peer Review Only 0 glutaredoxin 3-30 0 manganese/iron transport system ATP-binding protein-08 0 sulfite reductase (NADPH) flavoprotein alpha-component [EC:1.8.1.2]-01 0.01 ribonuclease PH [EC:2.7.7.56]-30 0 nucleobase:cation symporter-2; NCS2 family-01 0.01 intron-binding protein aquarius-08 0 E3 ubiquitin-protein ligase HERC2 [EC:6.3.2.19]-08 0 ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]-01 0.01 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30]-08 0.01 structural maintenance of chromosome 2-08 0 dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12-01 0.02 ferredoxin--NADP+ reductase [EC:1.18.1.2]-01 0.01 DNA replication and repair protein RecF-30 0 kinesin family member 18/19-30 0.01 nucleoside-triphosphate pyrophosphatase [EC:3.6.1.19]-30 0 MraZ protein-30 0 triosephosphate isomerase (TIM) [EC:5.3.1.1]-01 0.02 DNA-directed RNA polymerase I subunit A1 [EC:2.7.7.6]-08 0 peptidyl-tRNA hydrolase; PTH1 family [EC:3.1.1.29]-01 0.01 formyltetrahydrofolate deformylase [EC:3.5.1.10]-30 0 ABC-2 type transport system permease protein-30 0 translation initiation factor SUI1-08 0.01 RNA polymerase sigma factor for flagellar operon FliA-08 0.01 CDP-6-deoxy-D-xylo-4-hexulose-3-dehydrase-08 0.01 peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]-30 0 large subunit ribosomal protein L3-30 0.01 ribosomal protein L11 methyltransferase [EC:2.1.1.-]-01 0.01 ubiquitin-activating enzyme E1 [EC:6.3.2.19]-30 0.01 cytochrome bd-I oxidase subunit II [EC:1.10.3.-]-30 0 D-lactate dehydrogenase [EC:1.1.1.28]-08 0.01 Na+-transporting NADH:ubiquinone oxidoreductase subunit C-30 0 putative protein-disulfide isomerase-08 0.01 dimethylargininase [EC:3.5.3.18]-08 0.01 benzoate membrane transport protein-08 0.01 para-aminobenzoate synthetase component I [EC:2.6.1.85]-01 0.02 phospholipase C; delta [EC:3.1.4.11]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 645 of 848

glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]-30 0 small subunit ribosomal protein S4-30 0.01 adenosylcobyric acid synthase [EC:6.3.5.10]-30 0 colicin import membrane protein-01 0.01 dUTP pyrophosphatase [EC:3.6.1.23]-30 0.01 haloalkane dehalogenase [EC:3.8.1.5]-08 0.02 UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]-01 0.02 lignostilbene-alpha;beta-dioxygenase [EC:1.13.11.43]-08 0 large subunit ribosomal protein L5-30 0.01 Cu(I)/Ag(I) efflux system membrane protein CusB-30 0 cell division protein ForFtsB-08 Peer Review Only0.01 ribonuclease P protein component [EC:3.1.26.5]-08 0.01 putative thiamine transport system ATP-binding protein-08 0 arsenite-transporting ATPase [EC:3.6.3.16]-30 0.01 type III restriction enzyme [EC:3.1.21.5]-08 0.01 lysyl-tRNA synthetase; class I [EC:6.1.1.6]-30 0 hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]-08 0.01 dihydrodipicolinate reductase [EC:1.3.1.26]-30 0.01 hydroxyethylthiazole kinase [EC:2.7.1.50]-08 0.01 exopolyphosphatase [EC:3.6.1.11]-30 0 recombination protein RecR-30 0 3-demethylubiquinone-9 3-methyltransferase [EC:2.1.1.- 2.1.1.64]-01 0.02 AraC family transcriptional regulator; regulatory protein of-30 0 urea transport system substrate-binding protein-08 0 signal peptidase II [EC:3.4.23.36]-30 0 haloalkane dehalogenase [EC:3.8.1.5]-30 0 tRNA pseudouridine synthase B [EC:5.4.99.12]-01 0.01 E3 ubiquitin-protein ligase HUWE1 [EC:6.3.2.19]-30 0.01 large subunit ribosomal protein L20-30 0.01 long-chain-acyl-CoA dehydrogenase [EC:1.3.99.13]-08 0 alpha-galactosidase [EC:3.2.1.22]-30 0 putative iron-regulated protein-01 0.01 MSHA biogenesis protein MshQ-30 0 preprotein translocase subunit SecE-30 0 photosystem I subunit XI-08 0 ankyrin-30 0.01 ribosomal protein S6 modification protein-08 0 CRP/FNR family transcriptional regulator; cyclic AMP receptor-08 0.01 Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5]-30 0.01 ATP-binding cassette; subfamily C; bacterial-08 0.01 stage V sporulation protein R-08 0 ribose 5-phosphate isomerase A [EC:5.3.1.6]-30 0.01 rare lipoprotein A-30 0 large subunit ribosomal protein L6-01 0.02 elongation factor EF-P-30 0 adenylate kinase [EC:2.7.4.3]-01 0.02 heat shock 70kDa protein 5-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 646 of 848

oligoendopeptidase F [EC:3.4.24.-]-30 0 ATP phosphoribosyltransferase [EC:2.4.2.17]-30 0.01 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]-08 0.01 flagellar biosynthetic protein FliP-08 0.02 methylglutaconyl-CoA hydratase [EC:4.2.1.18]-08 0.01 tRNA/rRNA methyltransferase [EC:2.1.1.-]-30 0 sulfonate/nitrate/taurine transport system substrate-binding protein-01 0.02 ribonuclease III [EC:3.1.26.3]-01 0.01 large subunit ribosomal protein L4-01 0.01 glycine amidinotransferase [EC:2.1.4.1]-30 0 sn-glycerol 3-phosphateFor transport Peer system substrate-binding Review protein-01 Only0.01 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]-08 0.01 aminoacylhistidine dipeptidase [EC:3.4.13.3]-08 0.01 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase /-01 0.01 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]-01 0.02 amino-acid N-acetyltransferase [EC:2.3.1.1]-30 0.01 integrase/recombinase XerD-01 0.01 phosphoserine phosphatase [EC:3.1.3.3]-30 0 1;4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.-]-08 0.01 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.1.12]-30 0 ATP-dependent RNA helicase DOB1 [EC:3.6.1.-]-08 0 2;4-dienoyl-CoA reductase (NADPH2) [EC:1.3.1.34]-01 0.01 chemotaxis protein methyltransferase CheR [EC:2.1.1.80]-08 0 HlyD family secretion protein-30 0 uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase /-01 0.01 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide-01 0.02 transcriptional activator TenA [EC:3.5.99.2]-08 0.01 spermidine synthase [EC:2.5.1.16]-01 0.01 UDP-N-acetylglucosamine 2-epimerase [EC:5.1.3.14]-08 0.02 DNA polymerase alpha subunit A [EC:2.7.7.7]-08 0 cystathionine beta-synthase [EC:4.2.1.22]-30 0 dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]-01 0.01 ATP-dependent HslUV protease; peptidase subunit HslV [EC:3.4.25.-]-30 0 electron transfer flavoprotein alpha subunit-01 0.02 cell division protein ZapA-08 0.01 small subunit ribosomal protein S10-30 0 beta-aspartyl-peptidase (threonine type) [EC:3.4.19.5]-08 0.01 histidine transport system substrate-binding protein-08 0 ubiquitin-activating enzyme E1 [EC:6.3.2.19]-08 0 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit-01 0.01 arabinose-5-phosphate isomerase [EC:5.3.1.13]-01 0.02 GcrA cell cycle regulator-08 0.01 concentrative nucleoside transporter; CNT family-30 0 peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]-30 0 L-serine dehydratase [EC:4.3.1.17]-30 0 naphthoate synthase [EC:4.1.3.36]-08 0.01 segregation and condensation protein B-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 647 of 848

3-mercaptopyruvate sulfurtransferase [EC:2.8.1.2]-08 0.01 translation initiation factor eIF-2 gamma subunit-08 0 two-component system; chemotaxis family; response regulator CheV-08 0 Na+:H+ antiporter; NhaC family-30 0 mannosyl-3-phosphoglycerate phosphatase [EC:3.1.3.70]-08 0 large subunit ribosomal protein L16-30 0.01 glycine oxidase [EC:1.4.3.19]-30 0 protein phosphatase 2 (formerly 2A); regulatory subunit A-08 0 orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]-30 0 putative tungstate transport system ATP-binding protein-08 0.01 replication factor A1-08For Peer Review Only 0 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49]-01 0.01 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]-01 0.02 putative spermidine/putrescine transport system permease protein-30 0 polar amino acid transport system substrate-binding protein-30 0 2-dehydropantoate 2-reductase [EC:1.1.1.169]-30 0 transcriptional antiterminator NusG-01 0.01 glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]-30 0 dihydroflavonol-4-reductase [EC:1.1.1.219]-08 0.01 CDP-glucose 4;6-dehydratase [EC:4.2.1.45]-08 0.01 ornithine cyclodeaminase [EC:4.3.1.12]-30 0 2-oxoisovalerate dehydrogenase E1 component; alpha subunit-08 0.01 crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]-30 0 3-dehydroquinate dehydratase II [EC:4.2.1.10]-01 0.01 2-octaprenyl-6-methoxyphenol hydroxylase [EC:1.14.13.-]-01 0.02 D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4]-30 0 L-asparaginase [EC:3.5.1.1]-30 0 ATP-dependent RNA helicase DDX46/PRP5 [EC:3.6.1.-]-30 0.01 thiamine-monophosphate kinase [EC:2.7.4.16]-30 0 peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]-08 0.01 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]-30 0 thymidine kinase [EC:2.7.1.21]-30 0 sulfite reductase (NADPH) flavoprotein alpha-component [EC:1.8.1.2]-30 0 ferredoxin-nitrite reductase [EC:1.7.7.1]-30 0.01 membrane-bound lytic murein transglycosylase A [EC:3.2.1.-]-08 0 sn-glycerol 3-phosphate transport system permease protein-30 0 biopolymer transport protein TolQ-01 0.02 molecular chaperone HscB-08 0.01 omega-6 fatty acid desaturase (delta-12 desaturase) [EC:1.14.19.-]-30 0 succinate dehydrogenase cytochrome b-556 subunit [EC:1.3.99.1]-08 0.02 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide-30 0 DNA polymerase (family X)-08 0 AP-1 complex subunit gamma-1-30 0.01 zinc transport system ATP-binding protein [EC:3.6.3.-]-01 0.01 type IV pilus assembly protein PilN-01 0.01 pyridoxine biosynthesis protein [EC:4.-.-.-]-08 0 carboxypeptidase Taq [EC:3.4.17.19]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 648 of 848

curved DNA-binding protein-08 0 putative ABC transport system substrate-binding protein-30 0 gamma-aminobutyric acid (GABA) A receptor; epsilon-08 0.01 concentrative nucleoside transporter; CNT family-08 0 2-dehydropantoate 2-reductase [EC:1.1.1.169]-01 0.01 TetR/AcrR family transcriptional regulator; transcriptional-08 0.01 FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8]-30 0 translation initiation factor IF-2 unclassified subunit-30 0 DNA repair protein RecO (recombination protein O)-30 0 nitrile hydratase [EC:4.2.1.84]-08 0.01 RNA methyltransferase;For TrmA family Peer [EC:2.1.1.-]-01 Review Only0.01 uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107-08 0 NADH dehydrogenase I subunit E [EC:1.6.5.3]-30 0 uridine phosphorylase [EC:2.4.2.3]-08 0.01 adenine-specific DNA-methyltransferase [EC:2.1.1.72]-08 0.01 magnesium chelatase family protein-01 0.01 phosphomethylpyrimidine kinase [EC:2.7.4.7]-01 0.01 F-type H+-transporting ATPase subunit epsilon [EC:3.6.3.14]-30 0 acyl carrier protein-08 0.02 beta-mannosidase [EC:3.2.1.25]-08 0.01 threonine-phosphate decarboxylase [EC:4.1.1.81]-08 0 deoxyhypusine synthase [EC:2.5.1.46]-30 0 recombination protein RecR-01 0.01 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP-08 0.01 dihydroorotate dehydrogenase electron transfer subunit-08 0.01 UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]-30 0 ATP-dependent RNA helicase RhlB [EC:3.6.1.-]-30 0 ferredoxin-01 0.01 E1A/CREB-binding protein [EC:2.3.1.48]-08 0 dihydrodipicolinate reductase [EC:1.3.1.26]-01 0.02 hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]-08 0.01 alpha;alpha-trehalose-phosphate synthase (UDP-forming) [EC:2.4.1.15]-30 0 lipoyl(octanoyl) transferase [EC:2.3.1.181]-08 0.03 two-component system; chemotaxis family; response regulator CheY-30 0 taurine dioxygenase [EC:1.14.11.17]-30 0 DNA-binding protein HU-beta-01 0.01 nicotinate-nucleotide pyrophosphorylase (carboxylating)-30 0.01 stress-induced-phosphoprotein 1-08 0 indole-3-glycerol phosphate synthase [EC:4.1.1.48]-30 0 glutaminase [EC:3.5.1.2]-08 0.01 serine/threonine protein kinase; bacterial [EC:2.7.11.1]-30 0.01 26S proteasome regulatory subunit N2-30 0 transcriptional antiterminator RfaH-08 0.01 glucosylglycerol 3-phosphatase [EC:3.1.3.69]-08 0 nuclear receptor; other families; insect-30 0.01 flagellar basal-body rod protein FlgF-30 0 peptidyl-prolyl cis-trans isomerase C [EC:5.2.1.8]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 649 of 848

tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]-30 0 glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]-01 0.01 NADH dehydrogenase I subunit J [EC:1.6.5.3]-01 0.01 carbonic anhydrase [EC:4.2.1.1]-30 0 histone acetyltransferase MYST1 [EC:2.3.1.48]-08 0 23S ribosomal RNA-30 0.01 thiamine biosynthesis ThiG-30 0 flagellar basal-body rod protein FlgB-08 0.01 4-aminobutyrate aminotransferase [EC:2.6.1.19]-08 0 molybdenum cofactor biosynthesis protein C-30 0 cell division protein ForFtsQ-08 Peer Review Only0.02 DNA-binding protein HU-beta-30 0 D-alanyl-D-alanine carboxypeptidase /-08 0.01 DnaK suppressor protein-30 0 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]-30 0 small subunit ribosomal protein S13-01 0.01 ribosome recycling factor-01 0.01 putative adenine-specific DNA-methyltransferase [EC:2.1.1.72]-30 0 N-methylhydantoinase A [EC:3.5.2.14]-30 0 NADH dehydrogenase I subunit B [EC:1.6.5.3]-01 0.01 putative holliday junction resolvase [EC:3.1.-.-]-30 0 segregation and condensation protein A-30 0 ribosomal RNA small subunit methyltransferase C [EC:2.1.1.52]-30 0 small subunit ribosomal protein S18-08 0.01 aldehyde oxidase [EC:1.2.3.1]-08 0.01 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.1.12]-08 0.01 flagellar motor switch protein FliN/FliY-08 0.01 molecular chaperone IbpA-01 0 adenine phosphoribosyltransferase [EC:2.4.2.7]-01 0.01 V-type H+-transporting ATPase subunit B [EC:3.6.3.14]-08 0 glutamyl-tRNA reductase [EC:1.2.1.70]-30 0.01 calmodulin-08 0 phenylacetic acid degradation NADH oxidoreductase-30 0 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl-08 0.01 large subunit ribosomal protein L19-01 0.01 ATP phosphoribosyltransferase regulatory subunit-01 0.02 beta-hexosaminidase [EC:3.2.1.52]-30 0.01 enolase-phosphatase E1 [EC:3.1.3.77]-08 0 UDP-N-acetylglucosamine pyrophosphorylase [EC:2.7.7.23]-08 0.01 small subunit ribosomal protein S6-30 0 enoyl-[acyl carrier protein] reductase II [EC:1.3.1.-]-08 0.01 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase-30 0 phosphatidate cytidylyltransferase [EC:2.7.7.41]-30 0 1;2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [EC:1.13.11.53-08 0 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5]-08 0.01 kinesin family member 3/17-30 0 phosphonate transport system substrate-binding protein-08 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 650 of 848

alcohol dehydrogenase [EC:1.1.1.1]-01 0.02 insulysin [EC:3.4.24.56]-30 0.01 Fe-S cluster assembly ATP-binding protein-30 0 electron transfer flavoprotein beta subunit-01 0.02 splicing factor 3B subunit 3-08 0 precorrin-4 C11-methyltransferase [EC:2.1.1.133]-08 0.01 regulator of telomere elongation helicase 1-30 0.01 putative hydrolase of the HAD superfamily-01 0.02 adenylate cyclase [EC:4.6.1.1]-30 0 gluconate 5-dehydrogenase [EC:1.1.1.69]-08 0.01 aspartyl-tRNA(Asn)/glutamyl-tRNAFor Peer (Gln) amidotransferase Review subunit C-08 Only0.01 cytochrome c biogenesis protein-30 0.01 glutaryl-CoA dehydrogenase [EC:1.3.99.7]-01 0.01 CBS domain-containing protein-30 0 homocysteine S-methyltransferase [EC:2.1.1.10]-08 0 transcription initiation factor TFIID TATA-box-binding protein-08 0 malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]-08 0.01 cell division transport system ATP-binding protein-30 0 transcriptional regulator of aroF; aroG; tyrA and aromatic amino-30 0 replication factor C small subunit-08 0 MFS transporter; UMF1 family-30 0 5'-3' exoribonuclease 1 [EC:3.1.13.-]-08 0 two-component system; chemotaxis family; response regulator CheV-30 0 curli production assembly/transport component CsgG-08 0 NADH dehydrogenase I subunit B [EC:1.6.5.3]-30 0 ornithine--oxo-acid transaminase [EC:2.6.1.13]-30 0 penicillin-binding protein 1B [EC:2.4.1.129 3.4.-.-]-30 0 ATP-dependent RNA helicase DHX8/PRP22 [EC:3.6.1.-]-08 0 nitrogen fixation protein NifU and related proteins-01 0.01 PhnM protein-08 0 mannonate dehydratase [EC:4.2.1.8]-30 0 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]-01 0.01 salicylate hydroxylase [EC:1.14.13.1]-01 0.01 beta-ureidopropionase [EC:3.5.1.6]-08 0.01 two-component system; OmpR family; aerobic respiration control-30 0 UDP-N-acetylglucosamine 2-epimerase [EC:5.1.3.14]-30 0 RNA-directed DNA polymerase [EC:2.7.7.49]-08 0 X-Pro dipeptidase [EC:3.4.13.9]-01 0.02 dCTP deaminase [EC:3.5.4.13]-01 0.02 sn-glycerol 3-phosphate transport system substrate-binding protein-30 0 ribosomal large subunit pseudouridine synthase C [EC:5.4.99.12]-01 0.02 glycerol dehydrogenase [EC:1.1.1.6]-08 0 ABC-2 type transport system ATP-binding protein-30 0 large subunit ribosomal protein L32-08 0.01 histone H2A-08 0 ribosomal RNA small subunit methyltransferase E [EC:2.1.1.-]-01 0.02 putative endopeptidase [EC:3.4.24.-]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 651 of 848

type IV pilus assembly protein PilY1-08 0.01 formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]-01 0.02 phosphoserine / homoserine phosphotransferase [EC:3.1.3.3 2.7.1.39]-08 0.01 squalene-hopene cyclase [EC:5.4.99.17]-08 0 coatomer protein complex; subunit alpha (xenin)-08 0 ribosomal-protein-alanine N-acetyltransferase [EC:2.3.1.128]-30 0 triacylglycerol lipase [EC:3.1.1.3]-30 0 ubiquitin carboxyl-terminal hydrolase 8 [EC:3.1.2.15]-30 0 nitrogen fixation protein NifU and related proteins-30 0 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC:5.2.1.8]-08 0 ubiquinol-cytochromeFor c reductase Peer iron-sulfur subunit Review [EC:1.10.2.2]-01 Only0.01 molybdate transport system substrate-binding protein-08 0.01 phenol 2-monooxygenase [EC:1.14.13.7]-08 0.01 2-oxoisovalerate dehydrogenase E1 component; beta subunit-08 0.01 DNA-directed RNA polymerase; mitochondrial [EC:2.7.7.6]-30 0.01 putative biotin biosynthesis protein BioY-01 0.01 large subunit ribosomal protein L25-30 0 phytoene synthase [EC:2.5.1.32]-01 0.01 hippurate hydrolase [EC:3.5.1.32]-01 0.01 phosphatidylserine synthase [EC:2.7.8.8]-01 0.02 allophycocyanin-B-08 0 Na+-transporting NADH:ubiquinone oxidoreductase subunit B-01 0.01 enoyl-[acyl carrier protein] reductase II [EC:1.3.1.-]-30 0 purine-binding chemotaxis protein CheW-08 0.01 large subunit ribosomal protein L29-08 0.01 carboxymethylenebutenolidase [EC:3.1.1.45]-08 0 N-acylneuraminate cytidylyltransferase [EC:2.7.7.43]-30 0 Fur family transcriptional regulator; ferric uptake regulator-01 0.01 L-idonate 5-dehydrogenase [EC:1.1.1.264]-08 0.01 formamidase [EC:3.5.1.49]-08 0 UDP-glucose:tetrahydrobiopterin glucosyltransferase [EC:2.4.1.-]-08 0 xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2]-30 0.01 polyhydroxyalkanoate synthase [EC:2.3.1.-]-08 0.01 cytochrome o ubiquinol oxidase subunit III [EC:1.10.3.-]-08 0 mitochondrial processing peptidase [EC:3.4.24.64]-08 0.01 DNA repair and recombination protein RAD54 and RAD54-like protein-08 0 pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]-01 0.01 quinoprotein glucose dehydrogenase [EC:1.1.5.2]-30 0 phosphonate transport system substrate-binding protein-30 0 intron-binding protein aquarius-30 0.01 thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]-30 0 AFG3 family protein [EC:3.4.24.-]-08 0 2-oxoisovalerate dehydrogenase E1 component; alpha subunit-30 0 kinesin family member 2/24-30 0 pyruvate; water dikinase [EC:2.7.9.2]-30 0 small protein A-08 0.01 exodeoxyribonuclease VII large subunit [EC:3.1.11.6]-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 652 of 848

two-component system; OmpR family; phosphate regulon response-01 0.01 kynureninase [EC:3.7.1.3]-01 0.01 DNA polymerase delta subunit 1 [EC:2.7.7.7]-01 0 septum formation protein-01 0.01 E3 ubiquitin-protein ligase NEDD4 [EC:6.3.2.19]-30 0 translation initiation factor IF-1-30 0 solanesyl diphosphate synthase [EC:2.5.1.11]-08 0 molybdenum cofactor biosynthesis protein D-08 0.01 acetylornithine deacetylase [EC:3.5.1.16]-01 0.02 structural maintenance of chromosome 3 (chondroitin sulfate-30 0.01 beta-fructofuranosidaseFor [EC:3.2.1.26]-08 Peer Review Only 0 tryptophan 2-monooxygenase [EC:1.13.12.3]-08 0 acyl carrier protein-30 0.01 pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]-01 0.01 fumarylacetoacetase [EC:3.7.1.2]-30 0 phosphoribosylanthranilate isomerase [EC:5.3.1.24]-01 0.01 regulator of sigma D-08 0.01 F-type H+-transporting ATPase subunit delta [EC:3.6.3.14]-01 0.02 large subunit ribosomal protein L36-08 0.01 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]-01 0.01 kinesin family member 2/24-08 0 dTMP kinase [EC:2.7.4.9]-30 0 AmpD protein-08 0.01 glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3]-30 0 formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]-30 0.01 methylmalonyl-CoA mutase; N-terminal domain [EC:5.4.99.2]-08 0 indole-3-glycerol phosphate synthase [EC:4.1.1.48]-01 0.02 DNA-directed RNA polymerase III subunit C2 [EC:2.7.7.6]-30 0.01 cystathionine gamma-lyase [EC:4.4.1.1]-08 0.01 D-aminopeptidase [EC:3.4.11.19]-08 0.01 D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]-30 0 type III pantothenate kinase [EC:2.7.1.33]-01 0.01 minichromosome maintenance protein 8-30 0 N-acetylglucosamine-6-sulfatase [EC:3.1.6.14]-08 0 ABC-2 type transport system permease protein-01 0.01 ADP-ribose pyrophosphatase [EC:3.6.1.13]-30 0 valine--pyruvate aminotransferase [EC:2.6.1.66]-01 0.01 precorrin-2 C20-methyltransferase / cobalt-factor-2-08 0.01 ferrous iron transport protein B-01 0.01 arylsulfatase B [EC:3.1.6.12]-08 0 general secretion pathway protein F-08 0.01 large subunit ribosomal protein L14-01 0.01 cytochrome c-type biogenesis protein CcmE-01 0.01 glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]-01 0.01 sarcosine oxidase; subunit gamma [EC:1.5.3.1]-01 0.01 lipoprotein-30 0 starvation-inducible DNA-binding protein-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 653 of 848

protein transport protein SEC61 subunit alpha-08 0 orotate phosphoribosyltransferase [EC:2.4.2.10]-01 0.01 uridylate kinase [EC:2.7.4.22]-01 0.01 guanylate kinase [EC:2.7.4.8]-30 0.01 glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]-30 0 16S rRNA processing protein RimM-30 0 Na+-transporting NADH:ubiquinone oxidoreductase subunit F-30 0 N-formylglutamate deformylase [EC:3.5.1.68]-08 0.01 glutathione-regulated potassium-efflux system ancillary protein KefC-30 0 component of ribonucleoprotein particle-08 0 small subunit ribosomalFor protein S8-30Peer Review Only 0 ribosomal large subunit pseudouridine synthase B [EC:5.4.99.12]-30 0.01 dipeptidyl-peptidase 4 [EC:3.4.14.5]-01 0.01 thioredoxin 2 [EC:1.8.1.8]-08 0 N-methylhydantoinase B [EC:3.5.2.14]-30 0 thymidine kinase [EC:2.7.1.21]-01 0.01 imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]-01 0.02 nucleoside-diphosphate kinase [EC:2.7.4.6]-01 0.01 threonine aldolase [EC:4.1.2.5]-30 0.01 nicotinamide mononucleotide transporter-30 0 glyceraldehyde-3-phosphate dehydrogenase (NADP) [EC:1.2.1.9]-08 0.01 replication factor C subunit 3/5-08 0 serine--glyoxylate transaminase [EC:2.6.1.45]-30 0 magnesium chelatase subunit D [EC:6.6.1.1]-30 0.01 two-component system; OmpR family; sensor histidine kinase TctE-08 0 nucleoside-triphosphatase [EC:3.6.1.15]-01 0.01 transcriptional repressor NrdR-01 0.01 RIO kinase 1 [EC:2.7.11.1]-30 0 large subunit ribosomal protein L10-01 0.02 proton-dependent oligopeptide transporter; POT family-01 0.01 DNA polymerase bacteriophage-type [EC:2.7.7.7]-01 0.01 AP-2 complex subunit alpha-30 0 beta-aspartyl-peptidase (threonine type) [EC:3.4.19.5]-30 0 20S proteasome subunit beta 7 [EC:3.4.25.1]-08 0 manganese/iron transport system permease protein-30 0 electron transport complex protein RnfC-30 0 Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5]-08 0 S-adenosylmethionine-dependent methyltransferase-08 0 isovaleryl-CoA dehydrogenase [EC:1.3.99.10]-30 0 DNA mismatch repair protein MSH6-30 0.01 CCR4-NOT transcription complex subunit 6 [EC:3.1.-.-]-30 0 galactarate dehydratase [EC:4.2.1.42]-30 0 GntR family transcriptional regulator-30 0 3-carboxy-cis;cis-muconate cycloisomerase [EC:5.5.1.2]-08 0.01 methylthioribulose-1-phosphate dehydratase [EC:4.2.1.109]-08 0 twitching motility protein PilU-08 0 small subunit ribosomal protein S21-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 654 of 848

dihydrofolate reductase [EC:1.5.1.3]-01 0.01 D-alanyl-D-alanine carboxypeptidase /-30 0 minichromosome maintenance protein 6-08 0 single-strand DNA-binding protein-01 0.01 glutamate synthase (NADPH/NADH) [EC:1.4.1.13 1.4.1.14]-08 0 phosphatidylserine decarboxylase [EC:4.1.1.65]-01 0.02 RNA polymerase nonessential primary-like sigma factor-30 0 structural maintenance of chromosome 4-30 0.01 leader peptidase (prepilin peptidase) / N-methyltransferase-30 0 proliferating cell nuclear antigen-08 0 oxaloacetate decarboxylase;For beta Peer subunit [EC:4.1.1.3]-30 Review Only 0 HemY protein-30 0 serine O-acetyltransferase [EC:2.3.1.30]-01 0.01 chloramphenicol-sensitive protein RarD-30 0 N-acetylmuramic acid 6-phosphate etherase [EC:4.2.-.-]-08 0.01 putrescine transport system ATP-binding protein-01 0.01 S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase-08 0 large subunit ribosomal protein L11-01 0.01 6-phosphogluconate dehydrogenase [EC:1.1.1.44]-30 0.01 translation initiation factor IF-3-30 0 acetolactate synthase I/III small subunit [EC:2.2.1.6]-30 0 ribonuclease Z [EC:3.1.26.11]-30 0 flagellar protein FliS-08 0.01 T-complex protein 1 subunit delta-08 0 sec-independent protein translocase protein TatA-08 0.01 aminobenzoyl-glutamate transport protein-30 0 membrane-bound lytic murein transglycosylase B [EC:3.2.1.-]-30 0 sodium/proline symporter-30 0 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]-30 0 indolepyruvate ferredoxin oxidoreductase [EC:1.2.7.8]-30 0 two-component system; OmpR family; torCAD operon response regulator-08 0 maleylacetoacetate isomerase [EC:5.2.1.2]-08 0.01 general L-amino acid transport system ATP-binding protein-01 0.01 homoserine O-succinyltransferase [EC:2.3.1.46]-01 0.01 cb-type cytochrome c oxidase subunit III [EC:1.9.3.1]-30 0 ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.1.2.15]-30 0.01 crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]-01 0.01 DNA topoisomerase VI subunit A [EC:5.99.1.3]-08 0 5'-3' exoribonuclease 2 [EC:3.1.13.-]-08 0 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]-01 0.01 putative glutathione S-transferase-01 0.01 ubiquitin carboxyl-terminal hydrolase 4/11/15 [EC:3.1.2.15]-08 0 ATP phosphoribosyltransferase [EC:2.4.2.17]-01 0.02 D-alanyl-D-alanine dipeptidase [EC:3.4.13.-]-08 0.01 minichromosome maintenance protein 2-08 0 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate-08 0.01 ribosomal large subunit pseudouridine synthase E [EC:5.4.99.12]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 655 of 848

glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]-01 0.01 E3 ubiquitin-protein ligase UBR4 [EC:6.3.2.19]-08 0 casein kinase 2; alpha polypeptide [EC:2.7.11.1]-08 0 6-phosphogluconate dehydrogenase [EC:1.1.1.44]-01 0.01 repressor LexA [EC:3.4.21.88]-01 0.01 cytochrome bd-I oxidase subunit II [EC:1.10.3.-]-08 0 lysine 2;3-aminomutase [EC:5.4.3.2]-08 0 twitching motility protein PilU-30 0 arylsulfatase [EC:3.1.6.1]-30 0 cb-type cytochrome c oxidase subunit I [EC:1.9.3.1]-08 0 tRNA (guanine-N7-)-methyltransferaseFor Peer [EC:2.1.1.33]-01 Review Only0.01 ribonuclease HI [EC:3.1.26.4]-30 0 acetyl-CoA acyltransferase [EC:2.3.1.16]-01 0.01 DNA repair protein RecO (recombination protein O)-01 0.01 structural maintenance of chromosome 4-08 0 purine-nucleoside phosphorylase [EC:2.4.2.1]-30 0 NADPH2:quinone reductase [EC:1.6.5.5]-01 0.01 lipoprotein-34-08 0 6-pyruvoyl tetrahydrobiopterin synthase [EC:4.2.3.12]-01 0.01 Lrp/AsnC family transcriptional regulator; regulator for asnA; asnC-08 0 heptosyltransferase I [EC:2.4.-.-]-30 0 O-succinylhomoserine sulfhydrylase [EC:2.5.1.-]-30 0 actin beta/gamma 1-08 0 carbon storage regulator-08 0.01 3D-(3;5/4)-trihydroxycyclohexane-1;2-dione hydrolase [EC:3.7.1.-]-30 0 large subunit ribosomal protein L7/L12-01 0.01 ATP synthase protein I-08 0.01 NAD+ synthase [EC:6.3.1.5]-30 0 2-oxoglutarate ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3]-30 0 peptidylprolyl isomerase [EC:5.2.1.8]-30 0 lipoprotein-01 0.01 phosphoribulokinase [EC:2.7.1.19]-08 0 succinate dehydrogenase cytochrome b-556 subunit [EC:1.3.99.1]-01 0.01 guanylate kinase [EC:2.7.4.8]-01 0.01 hypothetical chaperone protein-30 0 biotin synthetase [EC:2.8.1.6]-01 0.01 DNA-3-methyladenine glycosylase II [EC:3.2.2.21]-01 0.01 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]-30 0 tRNA 2-selenouridine synthase [EC:2.9.1.-]-30 0 alanine racemase [EC:5.1.1.1]-01 0.01 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase-30 0 altronate hydrolase [EC:4.2.1.7]-01 0.01 large subunit ribosomal protein L17-01 0.01 glycerol dehydratase large subunit [EC:4.2.1.30]-08 0 phosphopentomutase [EC:5.4.2.7]-30 0 phosphate transport system protein-08 0.01 DnaK suppressor protein-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 656 of 848

general secretion pathway protein L-08 0.01 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase-08 0 putative signal transduction protein containing EAL and modified-30 0 two-component system; OmpR family; response regulator RpaB-08 0 3-isopropylmalate dehydratase [EC:4.2.1.33]-30 0 tRNA-dihydrouridine synthase 3 [EC:1.-.-.-]-08 0 heme exporter protein C-30 0 small subunit ribosomal protein S21-08 0.01 prolyl oligopeptidase [EC:3.4.21.26]-01 0.01 tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]-30 0 myosin V-30 For Peer Review Only0.01 alpha-1;3-glucosyltransferase [EC:2.4.1.-]-08 0 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.1.12]-01 0.01 uracil-DNA glycosylase [EC:3.2.2.-]-30 0 phosphate acetyltransferase [EC:2.3.1.8]-01 0.01 catechol 2;3-dioxygenase [EC:1.13.11.2]-08 0 two-component system; cell cycle sensor histidine kinase and-08 0 NADH dehydrogenase I subunit 5 [EC:1.6.5.3]-30 0 intestinal mucin-2-30 0.01 glycolate oxidase [EC:1.1.3.15]-30 0 exodeoxyribonuclease V beta subunit [EC:3.1.11.5]-01 0 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193]-08 0 phosphotransferase system; enzyme I; PtsP [EC:2.7.3.9]-01 0.01 beta-mannosidase [EC:3.2.1.25]-30 0 phosphatidylinositol 4-kinase [EC:2.7.1.67]-30 0.01 gyoxylate/hydroxypyruvate reductase A [EC:1.1.1.79 1.1.1.81]-01 0.01 biotin synthesis protein BioC-08 0.01 pyruvate carboxylase [EC:6.4.1.1]-01 0.01 protein phosphatase 1; catalytic subunit [EC:3.1.3.16]-30 0 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate-01 0.01 agmatine deiminase [EC:3.5.3.12]-08 0 ATP-dependent RNA helicase DOB1 [EC:3.6.1.-]-30 0 D-sorbitol dehydrogenase (acceptor) [EC:1.1.99.21]-08 0 phytoene synthase [EC:2.5.1.32]-30 0 ATP-binding cassette; sub-family F; member 2-08 0 superoxide dismutase; Fe-Mn family [EC:1.15.1.1]-30 0 rhamnose transport system substrate-binding protein-08 0 phenylacetic acid degradation operon negative regulatory protein-08 0 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]-01 0.01 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD [EC:4.1.1.-]-01 0 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P-01 0.01 adenine phosphoribosyltransferase [EC:2.4.2.7]-30 0 F-type H+-transporting ATPase subunit c [EC:3.6.3.14]-30 0.01 proliferating cell nuclear antigen-30 0 protochlorophyllide reductase [EC:1.3.1.33]-30 0 nicotinate phosphoribosyltransferase [EC:2.4.2.11]-30 0 dynactin 1-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 657 of 848

small subunit ribosomal protein S15-30 0 7;8-dihydro-8-oxoguanine triphosphatase [EC:3.6.1.-]-01 0.01 putative transcriptional regulator-01 0.01 RNA methyltransferase; TrmH family-30 0 acyl-CoA oxidase [EC:1.3.3.6]-08 0 bile acid:Na+ symporter; BASS family-30 0 succinate dehydrogenase (ubiquinone) flavoprotein subunit-30 0 magnesium and cobalt transporter-30 0 ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]-01 0 small subunit ribosomal protein S11-01 0.01 molybdopterin oxidoreductase;For iron-sulfurPeer binding Review subunit-30 Only 0 ribosomal RNA small subunit methyltransferase B [EC:2.1.1.-]-01 0.01 rhamnose transport system ATP-binding protein [EC:3.6.3.17]-08 0.01 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]-30 0 molybdopterin oxidoreductase; iron-sulfur binding subunit-01 0.01 thiamine biosynthesis ThiG-01 0.01 homoserine kinase [EC:2.7.1.39]-30 0 ribosomal small subunit pseudouridine synthase A [EC:5.4.99.12]-30 0 small subunit ribosomal protein S14-30 0 PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]-30 0 large subunit ribosomal protein L13-01 0.01 signal peptidase II [EC:3.4.23.36]-01 0.01 STE24 endopeptidase [EC:3.4.24.84]-01 0.01 ATP-dependent DNA helicase Rep [EC:3.6.1.-]-01 0.01 phosphate transport system ATP-binding protein [EC:3.6.3.27]-30 0 malonyl-CoA decarboxylase [EC:4.1.1.9]-01 0.01 HIV Tat-specific factor 1-30 0.01 DNA polymerase V [EC:3.4.21.-]-30 0 riboflavin synthase beta chain [EC:2.5.1.-]-30 0 glutathione peroxidase [EC:1.11.1.9]-01 0.01 2-oxo-hept-3-ene-1;7-dioate hydratase [EC:4.2.1.-]-08 0.01 SsrA-binding protein-01 0.01 carbon-monoxide dehydrogenase large subunit [EC:1.2.99.2]-30 0 phycoerythrobilin:ferredoxin oxidoreductase [EC:1.3.7.3]-08 0 colicin import membrane protein-30 0.01 photosynthetic reaction center M subunit-08 0 tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.25-01 0.01 selenide; water dikinase [EC:2.7.9.3]-30 0 UDP-2;3-diacylglucosamine hydrolase [EC:3.6.1.-]-01 0.01 kinesin family member 3/17-08 0 ribulose-bisphosphate carboxylase small chain [EC:4.1.1.39]-08 0.01 hydroxyatrazine ethylaminohydrolase [EC:3.5.99.3]-01 0.01 integrase/recombinase XerC-01 0.01 putative thioredoxin-30 0 large subunit ribosomal protein L21-30 0 fructose-2;6-bisphosphatase [EC:3.1.3.46]-08 0 succinylglutamic semialdehyde dehydrogenase [EC:1.2.1.71]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 658 of 848

DNA polymerase bacteriophage-type [EC:2.7.7.7]-30 0 STE24 endopeptidase [EC:3.4.24.84]-08 0.01 preprotein translocase subunit SecG-08 0.01 NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:1.6.5.3 1.6.99.3]-08 0 asparaginyl-tRNA synthetase [EC:6.1.1.22]-01 0.01 Na+-transporting NADH:ubiquinone oxidoreductase subunit A-01 0.01 5'-AMP-activated protein kinase; catalytic alpha subunit-30 0 trimethylamine dehydrogenase [EC:1.5.8.2]-08 0 carnitinyl-CoA dehydratase [EC:4.2.1.-]-01 0.01 thiamine biosynthesis lipoprotein-01 0.01 DNA processing protein-30For Peer Review Only 0 gamma-glutamylputrescine oxidase [EC:1.4.3.-]-01 0.01 succinate dehydrogenase hydrophobic membrane anchor protein-08 0.01 peroxiredoxin (alkyl hydroperoxide reductase subunit C)-30 0 small subunit ribosomal protein S21-30 0 AMP nucleosidase [EC:3.2.2.4]-30 0 type IV pilus assembly protein PilN-30 0 large subunit ribosomal protein L19-30 0 aminopeptidase [EC:3.4.11.-]-08 0.01 alpha-methylacyl-CoA racemase [EC:5.1.99.4]-08 0.01 ribosomal RNA large subunit methyltransferase E [EC:2.1.1.-]-30 0 PepB aminopeptidase [EC:3.4.11.23]-30 0 antiviral helicase SKI2 [EC:3.6.1.-]-08 0 cyanophycin synthetase [EC:6.-.-.-]-08 0 small conductance mechanosensitive ion channel; MscS family-08 0 DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]-01 0.01 putative endonuclease-30 0 conserved hypothetical protein-30 0 cellulose synthase (UDP-forming) [EC:2.4.1.12]-08 0 paired amphipathic helix protein Sin3a-30 0.01 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl-08 0 dolichol-phosphate mannosyltransferase [EC:2.4.1.83]-08 0 N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]-08 0 tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]-30 0 putative sigma-54 modulation protein-08 0.01 putative acyl-CoA dehydrogenase-08 0 2-alkenal reductase [EC:1.3.1.74]-08 0.01 ammonium transporter; Amt family-01 0.01 protein kinase A [EC:2.7.11.11]-30 0 large subunit ribosomal protein L21-01 0.01 urea carboxylase [EC:6.3.4.6]-08 0 biopolymer transport protein ExbD-01 0.01 phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19]-30 0 glycoside/pentoside/hexuronide:cation symporter; GPH family-08 0 pyrroloquinoline quinone biosynthesis protein B-30 0 glutamate carboxypeptidase [EC:3.4.17.11]-08 0.01 3-dehydroquinate dehydratase II [EC:4.2.1.10]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 659 of 848

NAD-dependent deacetylase [EC:3.5.1.-]-30 0 CDP-4-dehydro-6-deoxyglucose reductase [EC:1.17.1.1]-08 0 photosystem I subunit VII-08 0 nucleobase:cation symporter-2; NCS2 family-30 0.01 DNA repair and recombination protein RAD54 and RAD54-like protein-30 0.01 N-methylhydantoinase B [EC:3.5.2.14]-01 0.01 homoserine O-succinyltransferase [EC:2.3.1.46]-30 0 propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]-30 0 NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]-01 0.01 HAD superfamily phosphatase-08 0 acyl-CoA thioesteraseFor II [EC:3.1.2.-]-30 Peer Review Only 0 aminotransferase [EC:2.6.1.-]-01 0.01 glutamate-ammonia-ligase adenylyltransferase [EC:2.7.7.42]-01 0.01 exodeoxyribonuclease V [EC:3.1.11.5]-30 0 small subunit ribosomal protein S15-01 0.01 peptidyl-dipeptidase Dcp [EC:3.4.15.5]-01 0.01 cytochrome c-type biogenesis protein CcmE-30 0 protein phosphatase 2 (formerly 2A); regulatory subunit B'-08 0 SNW domain-containing protein 1-30 0 serine/threonine protein phosphatase 1 [EC:3.1.3.16]-08 0.01 putative family 31 glucosidase-08 0 transcription elongation factor GreA-01 0.01 translation initiation factor eIF-4F-30 0 putative lipoprotein-30 0 unspecific monooxygenase [EC:1.14.14.1]-08 0 phosphinothricin acetyltransferase [EC:2.3.1.183]-08 0.01 BolA protein-08 0.01 polysaccharide export outer membrane protein-08 0.01 DNA mismatch repair protein MSH2-08 0 pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]-01 0.01 circumsporozoite protein-30 0 phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]-01 0.01 xanthine dehydrogenase small subunit [EC:1.17.1.4]-01 0.01 para-aminobenzoate synthetase component II [EC:2.6.1.85]-08 0 glutamate/aspartate transport system permease protein-08 0 nicotinamide mononucleotide transporter-08 0.01 large subunit ribosomal protein L15-01 0.01 GntR family transcriptional regulator / MocR family aminotransferase-30 0 carnitine O-acetyltransferase [EC:2.3.1.7]-30 0 cell division protein FtsW-30 0.01 isochorismate synthase [EC:5.4.4.2]-08 0 multiple antibiotic resistance protein-01 0.01 L-asparaginase [EC:3.5.1.1]-01 0.01 small subunit ribosomal protein S5-30 0.01 molybdopterin-guanine dinucleotide biosynthesis protein B-08 0 peptidoglycan-associated lipoprotein-01 0.01 N-methylhydantoinase A [EC:3.5.2.14]-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 660 of 848

phytoene dehydrogenase; phytoene desaturase [EC:1.14.99.-]-30 0 alkyl hydroperoxide reductase subunit F [EC:1.6.4.-]-08 0 replication factor C small subunit-01 0 NADH dehydrogenase [EC:1.6.99.3]-01 0.01 UDP-N-acetyl-D-mannosaminuronic acid transferase [EC:2.4.1.-]-08 0 peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]-01 0.01 DNA-directed RNA polymerase II subunit B [EC:2.7.7.6]-01 0 kynurenine 3-monooxygenase [EC:1.14.13.9]-08 0 ribokinase [EC:2.7.1.15]-01 0 lanosterol synthase [EC:5.4.99.7]-30 0 cytochrome c-01 For Peer Review Only0.01 26S proteasome regulatory subunit N11-08 0 lysophospholipase [EC:3.1.1.5]-08 0 small subunit ribosomal protein S9-01 0.01 DNA-3-methyladenine glycosylase I [EC:3.2.2.20]-30 0 photosystem I subunit II-08 0 DNA polymerase V [EC:3.4.21.-]-01 0.01 lipopolysaccharide export system protein LptA-30 0 large subunit ribosomal protein L33-08 0.01 homogentisate 1;2-dioxygenase [EC:1.13.11.5]-30 0 cAMP-dependent protein kinase regulator-08 0 type VI secretion system protein ImpG-30 0 multiple sugar transport system ATP-binding protein-30 0 acetylornithine aminotransferase [EC:2.6.1.11]-01 0 protoporphyrinogen oxidase [EC:1.3.3.4]-30 0.01 tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]-08 0.01 protease IV [EC:3.4.21.-]-01 0.01 N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.87]-30 0 adenosine deaminase [EC:3.5.4.4]-30 0.01 26S proteasome regulatory subunit N1-08 0 tRNA-dihydrouridine synthase 1 [EC:1.-.-.-]-08 0 3-oxoadipate enol-lactonase [EC:3.1.1.24]-08 0.01 4-hydroxybenzoyl-CoA thioesterase [EC:3.1.2.23]-08 0.01 glutamate decarboxylase [EC:4.1.1.15]-08 0 small subunit ribosomal protein S10-01 0.01 large subunit ribosomal protein L22-30 0.01 riboflavin synthase alpha chain [EC:2.5.1.9]-01 0.01 pantoate--beta-alanine ligase [EC:6.3.2.1]-30 0 ferredoxin; 2Fe-2S-30 0 photosystem II reaction center 13kDa protein-08 0 NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:1.6.5.3 1.6.99.3]-08 0 photosystem I subunit III-08 0.01 FdhD protein-01 0.02 DNA mismatch repair protein MutS2-01 0.01 ubiquinone biosynthesis monooxygenase Coq7 [EC:1.14.13.-]-30 0 chemotaxis protein MotB-01 0.01 5'-nucleotidase / UDP-sugar diphosphatase [EC:3.1.3.5 3.6.1.45]-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 661 of 848

rod shape-determining protein MreC-01 0.02 phosphonate transport system permease protein-30 0 general secretion pathway protein F-30 0 cytochrome bd-I oxidase subunit I [EC:1.10.3.-]-08 0 iron(III) transport system ATP-binding protein [EC:3.6.3.30]-01 0.01 cyanophycin synthetase [EC:6.-.-.-]-30 0 NADH dehydrogenase I subunit 7 [EC:1.6.5.3]-08 0 Na+:H+ antiporter; NhaB family-01 0 tRNA 2-selenouridine synthase [EC:2.9.1.-]-01 0.01 SlyX protein-08 0.01 DNA polymerase alphaFor subunit APeer [EC:2.7.7.7]-30 Review Only 0 alpha-ketoglutarate-dependent 2;4-dichlorophenoxyacetate dioxygenase-08 0 nucleolin-30 0.01 carbon starvation protein-08 0 regulatory associated protein of mTOR-30 0 flagellar L-ring protein precursor FlgH-30 0 YggT family protein-30 0 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]-01 0.01 GTP cyclohydrolase II [EC:3.5.4.25]-30 0 formate dehydrogenase [EC:1.2.1.2]-01 0.01 serine palmitoyltransferase [EC:2.3.1.50]-08 0 polyhydroxybutyrate depolymerase-08 0 elongation factor EF-3-30 0.01 small subunit ribosomal protein S12-01 0.01 GDP-L-fucose synthase [EC:1.1.1.271]-01 0.01 Ca2+ transporting ATPase; sarcoplasmic/endoplasmic reticulum-08 0 NAD+ synthase [EC:6.3.1.5]-01 0.01 large subunit ribosomal protein L31-30 0 putative N6-adenine-specific DNA methylase-30 0 MFS transporter; DHA2 family; multidrug resistance protein B-08 0 regulator of ribonuclease activity A-30 0 GntR family transcriptional regulator; histidine utilization-01 0 small subunit ribosomal protein S8-01 0.01 large subunit ribosomal protein L9-01 0.01 NAD/factor-dependent formaldehyde dehydrogenase [EC:1.2.1.66]-08 0 methylthioribose-1-phosphate isomerase [EC:5.3.1.23]-01 0.01 ATP-binding cassette; subfamily B (MDR/TAP); member 1-08 0 acyl-CoA dehydrogenase [EC:1.3.99.-]-01 0 DNA repair protein RadC-30 0 phenylalanine-4-hydroxylase [EC:1.14.16.1]-01 0 starch synthase [EC:2.4.1.21]-01 0.01 periplasmic protein TonB-01 0.01 cathepsin X [EC:3.4.18.1]-08 0 lactate transporter; LctP family-08 0 acetoacetyl-CoA synthetase [EC:6.2.1.16]-30 0 leucine dehydrogenase [EC:1.4.1.9]-30 0 ribose 5-phosphate isomerase A [EC:5.3.1.6]-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 662 of 848

hydroxyneurosporene dehydrogenase-08 0 N utilization substance protein B-30 0 small subunit ribosomal protein S7-01 0.01 beta-fructofuranosidase [EC:3.2.1.26]-30 0 sulfonate/nitrate/taurine transport system ATP-binding protein-01 0.01 peptidyl-tRNA hydrolase; PTH2 family [EC:3.1.1.29]-08 0 lipoyl(octanoyl) transferase [EC:2.3.1.181]-01 0.01 negative regulator of flagellin synthesis FlgM-08 0 LAO/AO transport system kinase [EC:2.7.-.-]-30 0 circadian clock protein KaiA-08 0 sorbitol/mannitol transportFor system Peer permease protein-30 Review Only 0 2-phosphosulfolactate phosphatase [EC:3.1.3.71]-08 0 myo-inositol-1-phosphate synthase [EC:5.5.1.4]-08 0 catalase [EC:1.11.1.6]-30 0 cb-type cytochrome c oxidase subunit I [EC:1.9.3.1]-30 0 RNA-binding protein 25-30 0 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]-08 0 AsmA protein-08 0 translation initiation factor eIF-3 subunit 10-30 0.01 acetylornithine aminotransferase [EC:2.6.1.11]-30 0 imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]-30 0 host factor-I protein-08 0.01 glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]-30 0 Lon-like ATP-dependent protease [EC:3.4.21.-]-08 0 two-component system; OmpR family; phosphate regulon sensor-01 0.01 alpha-amylase [EC:3.2.1.1]-08 0 cobalamin biosynthesis protein CobW-30 0 alpha;alpha-trehalose-phosphate synthase (UDP-forming) [EC:2.4.1.15]-08 0 outer membrane lipoprotein carrier protein-08 0 cytochrome c-type biogenesis protein CcmH-30 0 cullin 3-08 0 erythronate-4-phosphate dehydrogenase [EC:1.1.1.290]-01 0.01 DNA damage-binding protein 1-08 0 structural maintenance of chromosome 1-30 0.01 ATP-dependent HslUV protease; peptidase subunit HslV [EC:3.4.25.-]-01 0.01 capsular polysaccharide transport system ATP-binding protein-08 0 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19]-08 0 flagellar FliL protein-08 0.01 molybdate transport system ATP-binding protein [EC:3.6.3.29]-01 0.01 heat shock protein HspQ-01 0.01 large subunit ribosomal protein L28-01 0.01 hypoxia up-regulated 1-08 0 L-cysteine/cystine lyase-08 0 glucose inhibited division protein Gid-30 0 beta-lactamase [EC:3.5.2.6]-08 0 calmodulin-30 0 selenide; water dikinase [EC:2.7.9.3]-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 663 of 848

dethiobiotin synthetase [EC:6.3.3.3]-30 0 cytochrome c6-08 0 glutamate dehydrogenase (NADP+) [EC:1.4.1.4]-30 0 regulator of telomere elongation helicase 1-08 0 type VI secretion system protein ImpG-08 0 holo-[acyl-carrier protein] synthase [EC:2.7.8.7]-30 0 polyhydroxyalkanoate synthase [EC:2.3.1.-]-30 0 putative iron-dependent peroxidase-30 0 UV DNA damage endonuclease [EC:3.-.-.-]-01 0 general secretion pathway protein D-01 0.01 transcription initiationFor factor TFIIB-08 Peer Review Only 0 Trp repressor binding protein-08 0.01 glutaconate CoA-transferase; subunit A [EC:2.8.3.12]-08 0 ATP-dependent RNA helicase [EC:3.6.1.-]-30 0 pyruvate carboxylase subunit B [EC:6.4.1.1]-08 0 DNA repair protein RAD50 [EC:3.6.-.-]-30 0.01 twitching motility protein PilT-01 0.01 bile acid:Na+ symporter; BASS family-01 0.01 phosphoadenosine phosphosulfate reductase [EC:1.8.4.8]-30 0 minichromosome maintenance protein 2-30 0.01 peptidoglycan glycosyltransferase [EC:2.4.1.129]-08 0 tRNA-(ms[2]io[6]A)-hydroxylase [EC:1.-.-.-]-30 0 nitroreductase [EC:1.-.-.-]-08 0.01 isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]-08 0 putative spermidine/putrescine transport system permease protein-01 0.01 glutathione-regulated potassium-efflux system ancillary protein KefC-08 0 nitrate reductase catalytic subunit [EC:1.7.99.4]-08 0.01 ATP-binding cassette; subfamily A (ABC1); member 3-08 0 lipopolysaccharide biosynthesis protein-08 0 xylose isomerase [EC:5.3.1.5]-30 0 ESCRT-II complex subunit VPS22-08 0 cytochrome c oxidase subunit XI assembly protein-01 0.01 PhnP protein-01 0.01 DnaJ homolog subfamily A member 2-08 0 glyoxylate reductase [EC:1.1.1.26]-08 0 aspartate 1-decarboxylase [EC:4.1.1.11]-08 0.01 flagellar hook-basal body complex protein FliE-08 0.01 endo-1;4-beta-xylanase [EC:3.2.1.8]-08 0 phosphogluconate dehydratase [EC:4.2.1.12]-01 0.01 DNA polymerase delta subunit 1 [EC:2.7.7.7]-30 0.01 butyryl-CoA dehydrogenase [EC:1.3.99.2]-30 0 peroxiredoxin Q/BCP [EC:1.11.1.15]-01 0.01 cell division protein FtsQ-01 0.01 holliday junction DNA helicase RuvA-30 0 Lrp/AsnC family transcriptional regulator; regulator for asnA; asnC-01 0 intracellular septation protein-01 0.01 phosphatidate cytidylyltransferase [EC:2.7.7.41]-01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 664 of 848

peptide alpha-N-acetyltransferase [EC:2.3.1.88]-08 0 peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11-01 0.01 acetolactate synthase I/III small subunit [EC:2.2.1.6]-01 0.01 microtubule-severing ATPase [EC:3.6.4.3]-08 0 riboflavin synthase beta chain [EC:2.5.1.-]-01 0.01 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]-30 0 betaine-homocysteine S-methyltransferase [EC:2.1.1.5]-08 0 BirA family transcriptional regulator; biotin operon repressor /-01 0.01 fructose-1;6-bisphosphatase I [EC:3.1.3.11]-01 0.01 heat shock protein HtpX [EC:3.4.24.-]-08 0 large subunit ribosomalFor protein L23-30Peer Review Only 0 outer membrane lipoprotein LolB-08 0 putative colanic acid biosynthesis acetyltransferase WcaF-08 0 large subunit ribosomal protein L27-30 0 manganese/zinc/iron transport system permease protein-01 0 tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]-08 0 quinoprotein glucose dehydrogenase [EC:1.1.5.2]-01 0 ribosomal RNA large subunit methyltransferase E [EC:2.1.1.-]-01 0.01 diacylglycerol kinase [EC:2.7.1.107]-01 0 rod shape-determining protein MreD-30 0 translation initiation factor eIF-3 subunit 10-08 0 primary-amine oxidase [EC:1.4.3.21]-08 0 translation initiation factor IF-1-01 0.01 pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]-01 0.01 competence protein ComEC-01 0 DNA-3-methyladenine glycosylase [EC:3.2.2.21]-08 0 acyl-CoA dehydrogenase [EC:1.3.99.3]-01 0.01 glycerate kinase [EC:2.7.1.31]-08 0 Na+-transporting NADH:ubiquinone oxidoreductase subunit D-01 0.01 N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26]-08 0.01 sialate O-acetylesterase [EC:3.1.1.53]-30 0 starch synthase [EC:2.4.1.21]-30 0 large subunit ribosomal protein L34-30 0 membrane glycosyltransferase [EC:2.4.1.-]-08 0 multicomponent K+:H+ antiporter subunit D-08 0 pyruvate carboxylase subunit A [EC:6.4.1.1]-08 0 putative colanic acid biosysnthesis UDP-glucose lipid carrier-08 0 3R-hydroxymyristoyl ACP dehydrase [EC:4.2.1.-]-01 0.01 pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]-30 0 glutaredoxin 3-08 0.01 casein kinase 2; beta polypeptide-30 0 large subunit ribosomal protein L27-01 0.01 protein-tyrosine phosphatase [EC:3.1.3.48]-01 0.01 translation initiation factor eIF-3 subunit 6-30 0.01 116 kDa U5 small nuclear ribonucleoprotein component-08 0 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]-08 0 DNA adenine methylase [EC:2.1.1.72]-01 0

Wiley-Blackwell and Society for Applied Microbiology Page 665 of 848

DNA excision repair protein ERCC-6-30 0 large subunit ribosomal protein L4-30 0.01 gamma-glutamylputrescine oxidase [EC:1.4.3.-]-30 0 small subunit ribosomal protein S9-30 0.01 ribosomal RNA large subunit methyltransferase L [EC:2.1.1.52]-01 0 DNA adenine methylase [EC:2.1.1.72]-30 0 segregation and condensation protein B-01 0.01 gyoxylate/hydroxypyruvate reductase A [EC:1.1.1.79 1.1.1.81]-30 0 ribosomal large subunit pseudouridine synthase A [EC:5.4.99.12]-01 0 26S proteasome regulatory subunit T1-08 0 splicing factor 3B subunitFor 3-30 Peer Review Only 0 8-amino-7-oxononanoate synthase [EC:2.3.1.47]-30 0 26S proteasome regulatory subunit T1-30 0 ribosomal protein S6 modification protein-01 0 two-component system; NarL family; sensor kinase [EC:2.7.13.3]-08 0 protein phosphatase 2 (formerly 2A); regulatory subunit B'-30 0 inosose dehydratase [EC:4.2.1.44]-01 0.01 5'-3' exoribonuclease 2 [EC:3.1.13.-]-30 0 protein-tyrosine phosphatase [EC:3.1.3.48]-30 0 molybdate transport system ATP-binding protein [EC:3.6.3.29]-30 0 cell division cycle 20; cofactor of APC complex-08 0 anthranilate synthase component II [EC:4.1.3.27]-01 0.01 deoxyribose-phosphate aldolase [EC:4.1.2.4]-01 0.01 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [EC:1.1.1.-]-08 0.01 phosphoribulokinase [EC:2.7.1.19]-01 0 flagellar FliL protein-30 0 porin-08 0 deoxyribose-phosphate aldolase [EC:4.1.2.4]-30 0 cytidylate kinase [EC:2.7.4.14]-01 0.02 competence protein ComEA-08 0 NADH dehydrogenase I subunit C [EC:1.6.5.3]-01 0.01 photosystem II oxygen-evolving complex 23kDa protein-08 0 thioredoxin 1-01 0.01 Ca2+:H+ antiporter-30 0 small subunit ribosomal protein S27Ae-08 0 glutamate dehydrogenase (NADP+) [EC:1.4.1.4]-01 0.01 purine-binding chemotaxis protein CheW-30 0 oligoendopeptidase F [EC:3.4.24.-]-01 0 long-chain fatty acid transport protein-08 0 mannose-1-phosphate guanylyltransferase [EC:2.7.7.22]-30 0 cholesterol oxidase [EC:1.1.3.6]-08 0 DNA excision repair protein ERCC-3 [EC:3.6.1.-]-30 0 structural maintenance of chromosome 3 (chondroitin sulfate-08 0 DNA ligase 1 [EC:6.5.1.1]-30 0 4-nitrophenyl phosphatase [EC:3.1.3.41]-08 0 ribosomal large subunit pseudouridine synthase E [EC:5.4.99.12]-01 0.01 hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]-30 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 666 of 848

SsrA-binding protein-30 0 polar amino acid transport system permease protein-30 0 enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase-08 0 glycine cleavage system H protein-01 0.01 general secretion pathway protein J-08 0 cardiolipin synthase [EC:2.7.8.-]-08 0 ATP-binding cassette; subfamily B (MDR/TAP); member 1-30 0 actin beta/gamma 1-30 0.01 Na+-transporting NADH:ubiquinone oxidoreductase subunit E-01 0.01 transcriptional regulator-08 0 MSHA biogenesis proteinFor MshJ-08 Peer Review Only 0 large subunit ribosomal protein L15-30 0 flagellar motor switch protein FliN/FliY-30 0 elongation factor EF-1 alpha subunit [EC:3.6.5.3]-30 0 putative drug exporter of the RND superfamily-08 0 carbamate kinase [EC:2.7.2.2]-08 0 26S proteasome regulatory subunit T5-30 0 hemoglobin-08 0 replication factor C subunit 2/4-08 0 tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase-01 0 3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.-]-30 0 transcription elongation factor SPT6-08 0 dephospho-CoA kinase [EC:2.7.1.24]-01 0.01 regulatory associated protein of mTOR-08 0 thimet oligopeptidase [EC:3.4.24.15]-08 0 polyvinyl-alcohol dehydrogenase (acceptor) [EC:1.1.99.23]-08 0 transposase-30 0 cob(I)alamin adenosyltransferase [EC:2.5.1.17]-01 0.01 general secretion pathway protein A-08 0.01 thiamine biosynthesis ThiS-08 0 ribonuclease HI [EC:3.1.26.4]-01 0.01 protein-L-isoaspartate(D-aspartate) O-methyltransferase-01 0.01 7;8-dihydro-8-oxoguanine triphosphatase [EC:3.6.1.-]-30 0 glyoxylase I family protein-08 0 cathepsin A [EC:3.4.16.5]-08 0 isoquinoline 1-oxidoreductase; beta subunit [EC:1.3.99.16]-01 0 arylsulfatase A [EC:3.1.6.8]-30 0 LysR family transcriptional regulator; regulator for metE and metH-30 0 RNA methyltransferase; TrmH family; group 2 [EC:2.1.1.-]-30 0 citrate lyase subunit beta [EC:4.1.3.6]-30 0 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate-01 0.01 dipeptidyl-peptidase 4 [EC:3.4.14.5]-30 0.01 ornithine--oxo-acid transaminase [EC:2.6.1.13]-01 0.01 phosphatidylinositol glycan; class Z [EC:2.4.1.-]-30 0 succinate dehydrogenase cytochrome b-556 subunit [EC:1.3.99.1]-30 0 T-complex protein 1 subunit eta-08 0 high-affinity iron transporter-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 667 of 848

histone deacetylase 1/2 [EC:3.5.1.98]-08 0 membrane-bound serine protease (ClpP class)-08 0 MFS transporter; MHS family; proline/betaine transporter-08 0 heptosyltransferase I [EC:2.4.-.-]-08 0 nucleoside-triphosphate pyrophosphatase [EC:3.6.1.19]-01 0.01 TNF receptor-associated protein 1-30 0 DeoR family transcriptional regulator; suf operon transcriptional-08 0 DNA-3-methyladenine glycosylase II [EC:3.2.2.21]-30 0 adenylylsulfate reductase; subunit B [EC:1.8.99.2]-01 0.01 multidrug resistance protein A-08 0 gentisate 1;2-dioxygenaseFor [EC:1.13.11.4]-08 Peer Review Only 0 type IV pilus assembly protein PilO-30 0 CCR4-NOT transcription complex subunit 1-30 0.01 precorrin-3B synthase [EC:1.14.13.83]-08 0 carboxyvinyl-carboxyphosphonate phosphorylmutase [EC:2.7.8.23]-08 0 NAD+ diphosphatase [EC:3.6.1.22]-30 0 DNA processing protein-01 0 dihydroneopterin aldolase [EC:4.1.2.25]-01 0.01 cold shock protein (beta-ribbon; CspA family)-01 0.01 3-hydroxyethyl bacteriochlorophyllide a dehydrogenase [EC:1.-.-.-]-08 0 twitching motility protein PilJ-08 0 short-chain fatty acids transporter-08 0.01 CarD family transcriptional regulator-30 0 flagellar P-ring protein precursor FlgI-30 0 flagellar protein FlgJ-08 0.01 vesicle-fusing ATPase [EC:3.6.4.6]-08 0 glycolate oxidase iron-sulfur subunit-30 0 membrane protein required for colicin V production-30 0 carotenoid cleavage dioxygenase-08 0 histone deacetylase 1/2 [EC:3.5.1.98]-30 0.01 altronate hydrolase [EC:4.2.1.7]-30 0 replicative DNA helicase Mcm [EC:3.6.1.-]-08 0 putative thiamine transport system permease protein-08 0.01 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate-08 0 uroporphyrin-III C-methyltransferase [EC:2.1.1.107]-30 0 peptidyl-dipeptidase A [EC:3.4.15.1]-01 0 stringent starvation protein A-01 0.01 enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase-30 0 Na+:H+ antiporter; NhaC family-01 0.01 translation initiation factor eIF-3 subunit 6-08 0 nonsense-mediated mRNA decay protein 3-08 0 1-aminocyclopropane-1-carboxylate deaminase [EC:3.5.99.7]-08 0 heme exporter protein A [EC:3.6.3.41]-30 0 magnesium and cobalt transporter-01 0.01 putrescine transport system substrate-binding protein-01 0 NADH dehydrogenase I subunit E [EC:1.6.5.3]-01 0.01 type VI secretion system protein ImpC-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 668 of 848

two-component system; NtrC family; sensor histidine kinase YfhK-30 0 citrate lyase subunit beta [EC:4.1.3.6]-01 0 flagellar hook-associated protein 2-30 0 alanine transaminase [EC:2.6.1.2]-30 0 uracil phosphoribosyltransferase [EC:2.4.2.9]-01 0.01 ribonucleotide reductase; class II [EC:1.17.4.1]-30 0 small subunit ribosomal protein S14-01 0.01 isopentenyl-diphosphate delta-isomerase [EC:5.3.3.2]-30 0 formate dehydrogenase; beta subunit [EC:1.2.1.2]-08 0.01 phospholipase A1 [EC:3.1.1.32]-30 0 3-hydroxybutyryl-CoAFor dehydratase Peer [EC:4.2.1.55]-08 Review Only 0 ornithine decarboxylase [EC:4.1.1.17]-30 0 putative holliday junction resolvase [EC:3.1.-.-]-01 0.01 cytochrome c peroxidase [EC:1.11.1.5]-01 0 flagellar biosynthetic protein FliQ-08 0 3-hydroxyanthranilate 3;4-dioxygenase [EC:1.13.11.6]-08 0 septum site-determining protein MinD-30 0 ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]-30 0.01 aspartate racemase [EC:5.1.1.13]-30 0 SEC-C motif domain protein-08 0.01 forkhead box protein P-30 0 type VI secretion system protein ImpL-30 0 dipeptidase E [EC:3.4.13.21]-08 0.01 tRNA-dihydrouridine synthase 3 [EC:1.-.-.-]-30 0 small subunit ribosomal protein S16-30 0.01 translation initiation factor eIF-2 alpha subunit-08 0 phosphatidylinositol 3-kinase [EC:2.7.1.137]-08 0 ribosomal large subunit pseudouridine synthase A [EC:5.4.99.12]-30 0 NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]-08 0 penicillin-binding protein 1C [EC:2.4.1.-]-08 0.01 leucyl/phenylalanyl-tRNA--protein transferase [EC:2.3.2.6]-01 0.01 glucose-6-phosphate 1-epimerase [EC:5.1.3.15]-30 0 thiol:disulfide interchange protein DsbD [EC:1.8.1.8]-30 0 glycosyl transferase; family 25-08 0 ATP-dependent RNA helicase DHX8/PRP22 [EC:3.6.1.-]-30 0 DNA-directed RNA polymerase subunit A' [EC:2.7.7.6]-08 0 sorbitol/mannitol transport system ATP-binding protein-30 0 NADH dehydrogenase I subunit A [EC:1.6.5.3]-01 0.01 delta-1-pyrroline-5-carboxylate synthetase [EC:2.7.2.11 1.2.1.41]-30 0 geranylgeranyl diphosphate synthase; type III [EC:2.5.1.1 2.5.1.10-08 0 large subunit ribosomal protein L4e-08 0 internalin A-08 0 heme exporter protein B-30 0 ATP-dependent Clp protease adaptor protein ClpS-30 0 proline iminopeptidase [EC:3.4.11.5]-01 0.01 Notch-30 0 cobalamin biosynthesis protein CbiG / precorrin-3B-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 669 of 848

gamma-aminobutyric acid (GABA) A receptor; epsilon-30 0 rod shape-determining protein MreD-08 0.01 photosystem I subunit VII-30 0 PTS system; mannose-specific IIA component [EC:2.7.1.69]-08 0 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]-30 0.01 2-octaprenyl-3-methyl-6-methoxy-1;4-benzoquinol hydroxylase-30 0 small subunit ribosomal protein S17-01 0.01 oligoribonuclease [EC:3.1.-.-]-01 0.01 ATP-dependent RNA helicase DDX1 [EC:3.6.1.-]-08 0 NADH dehydrogenase I subunit 4L [EC:1.6.5.3]-08 0 phycoerythrin-associatedFor linker protein-30Peer Review Only 0 molybdopterin oxidoreductase; molybdopterin binding subunit-30 0 DNA-directed RNA polymerase I subunit A2 [EC:2.7.7.6]-30 0 polycomb protein EED-08 0 sulfate permease; SulP family-01 0.01 DNA-directed RNA polymerase II subunit A [EC:2.7.7.6]-01 0 large subunit ribosomal protein L33-30 0 MerR family transcriptional regulator; Zn(II)-responsive regulator-08 0 MFS transporter; DHA1 family; bicyclomycin/chloramphenicol-01 0.01 outer membrane lipoprotein Blc-01 0 adenylyltransferase ThiF [EC:2.7.7.-]-08 0 flagellar hook-associated protein 3 FlgL-30 0 glycine dehydrogenase subunit 1 [EC:1.4.4.2]-08 0 cell division transport system ATP-binding protein-01 0 cell division protein FtsL-08 0 large subunit ribosomal protein L18-01 0.01 peroxiredoxin Q/BCP [EC:1.11.1.15]-30 0 ATP:ADP antiporter; AAA family-30 0 mitochondrial intermediate peptidase [EC:3.4.24.59]-30 0 lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]-30 0 nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-]-08 0.01 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19]-30 0 flagellar biosynthetic protein FliP-30 0 isohexenylglutaconyl-CoA hydratase [EC:4.2.1.57]-08 0.01 betaine-homocysteine S-methyltransferase [EC:2.1.1.5]-30 0 ATP-dependent RNA helicase SrmB [EC:2.7.7.-]-30 0 conjugal transfer mating pair stabilization protein TraN-30 0 6-pyruvoyl tetrahydrobiopterin synthase [EC:4.2.3.12]-30 0 solute carrier family 25 (mitochondrial carrier; adenine nucleotide-08 0 tRNA/rRNA methyltransferase [EC:2.1.1.-]-01 0.01 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX [EC:4.1.1.-]-30 0 succinate dehydrogenase hydrophobic membrane anchor protein-30 0 leucyl/phenylalanyl-tRNA--protein transferase [EC:2.3.2.6]-30 0 histone-lysine N-methyltransferase SUV420H [EC:2.1.1.43]-30 0 replication factor C subunit 1-08 0 fumarylacetoacetase [EC:3.7.1.2]-01 0 cytochrome c biogenesis protein CcmG; thiol:disulfide interchange-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 670 of 848

large subunit ribosomal protein L18-30 0 beta-lactamase [EC:3.5.2.6]-30 0 condensin complex subunit 1-30 0 pre-mRNA-splicing factor CWC26-30 0 myo-inositol 2-dehydrogenase [EC:1.1.1.18]-30 0 uracil-DNA glycosylase [EC:3.2.2.-]-01 0.01 cysteine desulfuration protein SufE-30 0 manganese/iron transport system substrate-binding protein-30 0 formate dehydrogenase [EC:1.2.1.2]-30 0 zinc finger CCHC domain-containing protein 8-30 0 large subunit ribosomalFor protein L35-08Peer Review Only0.01 molybdenum cofactor biosynthesis protein B-01 0.01 translation initiation factor eIF-3 subunit 8-30 0 F-type H+-transporting ATPase subunit c [EC:3.6.3.14]-01 0.01 type IV pilus assembly protein PilW-30 0 crooked neck-08 0 fructose transport system permease protein-08 0 nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]-01 0.01 regulatory protein-30 0 D-alanine transaminase [EC:2.6.1.21]-01 0.01 cystathionine gamma-synthase [EC:2.5.1.48]-30 0 ATP-independent RNA helicase DbpA-30 0 twitching motility protein PilJ-30 0 DedD protein-08 0 catalase [EC:1.11.1.6]-08 0 general secretion pathway protein I-08 0 two-component system; NarL family; sensor histidine kinase BarA-08 0 glutamate decarboxylase [EC:4.1.1.15]-30 0 acyl carrier protein-01 0.01 outer membrane protein OmpU-08 0 ribosome-binding factor A-30 0 MraZ protein-01 0.01 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]-01 0.01 protein kinase C substrate 80K-H-08 0 ATP-dependent RNA helicase DDX23/PRP28 [EC:3.6.1.-]-30 0 capsular polysaccharide export protein-30 0 large subunit ribosomal protein L34-08 0.01 ubiquinol-cytochrome c reductase cytochrome c1 subunit [EC:1.10.2.2]-01 0.01 pyridoxine kinase [EC:2.7.1.35]-30 0 Rrf2 family transcriptional regulator; iron-sulfur cluster assembly-01 0.01 heat shock protein 90kDa beta-30 0 arsenite transporter; ACR3 family-08 0 phosphopentomutase [EC:5.4.2.7]-01 0 CCR4-NOT complex subunit CAF16-08 0 methionine-gamma-lyase [EC:4.4.1.11]-30 0 1;2-diacylglycerol 3-glucosyltransferase [EC:2.4.1.157]-08 0 S-adenosylmethionine decarboxylase [EC:4.1.1.50]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 671 of 848

putative redox protein-01 0 exodeoxyribonuclease VII small subunit [EC:3.1.11.6]-08 0.01 ferrous iron transport protein B-30 0 putrescine aminotransferase [EC:2.6.1.-]-30 0 biotin synthesis protein BioC-30 0 citronellol/citronellal dehydrogenase-08 0 peroxiredoxin (alkyl hydroperoxide reductase subunit C)-01 0.01 pre-mRNA-splicing factor CWC22-30 0.01 large subunit ribosomal protein L9-30 0 transducin (beta)-like 1-30 0 DnaJ homolog subfamilyFor A member Peer 5-30 Review Only 0 ribosome-associated heat shock protein Hsp15-30 0 tRNA pseudouridine synthase D [EC:5.4.99.12]-30 0 26S proteasome regulatory subunit T6-30 0 putative acetyltransferase [EC:2.3.1.-]-30 0 ubiquitin carboxyl-terminal hydrolase 10 [EC:3.1.2.15]-30 0 kinesin family member C1-08 0 two-component system; sensor histidine kinase FlrB [EC:2.7.13.3]-08 0 putrescine transport system permease protein-30 0 diacylglycerol kinase [EC:2.7.1.107]-30 0 inositol-1;4;5-trisphosphate 5-phosphatase [EC:3.1.3.56]-30 0 UMP-CMP kinase [EC:2.7.4.- 2.7.4.14]-08 0 L-iditol 2-dehydrogenase [EC:1.1.1.14]-08 0 cell division protein FtsQ-30 0 2';3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16]-08 0 hydroxypyruvate reductase [EC:1.1.1.81]-30 0 homeobox protein cut-like-30 0 ribonuclease Z [EC:3.1.26.11]-01 0.01 acetyl-CoA carboxylase biotin carboxyl carrier protein-01 0.01 anthranilate synthase component II [EC:4.1.3.27]-30 0 26S proteasome regulatory subunit N6-08 0 UDP-sugar pyrophosphorylase [EC:2.7.7.64]-30 0 type I restriction enzyme; R subunit [EC:3.1.21.3]-01 0.01 general secretion pathway protein L-30 0 tRNA-dihydrouridine synthase B [EC:1.-.-.-]-01 0 galactosylceramidase [EC:3.2.1.46]-30 0 L-fuculose-phosphate aldolase [EC:4.1.2.17]-08 0 amino-acid N-acetyltransferase [EC:2.3.1.1]-01 0 glucosylceramidase [EC:3.2.1.45]-08 0.01 putative glutathione S-transferase-30 0.01 large subunit ribosomal protein L17-30 0 precorrin-6Y C5;15-methyltransferase / precorrin-8W decarboxylase-30 0 dynein heavy chain 2; cytosolic-30 0 type I restriction enzyme; S subunit [EC:3.1.21.3]-30 0 amidase [EC:3.5.1.4]-01 0 neurotransmitter:Na+ symporter; NSS family-01 0.01 3-oxoacid CoA-transferase [EC:2.8.3.5]-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 672 of 848

cohesin loading factor subunit SCC2-30 0 arsenical resistance protein ArsH-08 0 crooked neck-30 0 basic amino acid/polyamine antiporter; APA family-30 0 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]-30 0 flagellar biosynthesis protein FlhG-30 0 thiamine biosynthesis protein ThiI-30 0 protein HIRA/HIR1-30 0 flagellar biosynthesis protein FlhF-30 0 translation initiation factor SUI1-30 0 large subunit ribosomalFor protein L10e-08Peer Review Only 0 farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]-08 0 putative colanic acid biosysnthesis UDP-glucose lipid carrier-30 0 photosystem II PsbD protein-01 0 LysR family transcriptional regulator; transcriptional activator of-08 0 oligoribonuclease [EC:3.1.-.-]-30 0 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]-30 0 exonuclease SbcD-08 0 type VI secretion system protein ImpB-08 0 26S proteasome regulatory subunit N2-08 0 geranylgeranyl diphosphate synthase; type I [EC:2.5.1.1 2.5.1.10-01 0.01 large subunit ribosomal protein L28-30 0 AP-3 complex subunit delta-1-30 0 PTS system; nitrogen regulatory IIA component [EC:2.7.1.69]-30 0 putative redox protein-30 0 S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase-30 0 ariadne-1-30 0 cobyrinic acid a;c-diamide synthase [EC:6.3.5.9 6.3.1.-]-30 0 LemA protein-08 0 sugar fermentation stimulation protein A-30 0 adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]-30 0 gluconolactonase [EC:3.1.1.17]-30 0 glycolate oxidase FAD binding subunit-01 0.01 methylglyoxal synthase [EC:4.2.3.3]-08 0 rhamnosyltransferase [EC:2.4.1.-]-08 0 aspartate racemase [EC:5.1.1.13]-01 0.01 glucose-1-phosphate cytidylyltransferase [EC:2.7.7.33]-30 0 gluconokinase [EC:2.7.1.12]-08 0 NADH dehydrogenase (quinone) [EC:1.6.99.5]-08 0 manganese/iron transport system permease protein-01 0.01 NADH dehydrogenase I subunit I [EC:1.6.5.3]-01 0.01 acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2]-08 0 4-hydroxyphenylacetate-3-hydroxylase large chain [EC:1.14.13.3]-30 0 acyl-CoA thioesterase I [EC:3.1.2.- 3.1.1.5]-30 0 cell division transport system permease protein-01 0.01 preprotein translocase subunit YajC-01 0.01 ribonucleoside-triphosphate reductase [EC:1.17.4.2]-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 673 of 848

cullin 3-30 0 sarcosine oxidase; subunit delta [EC:1.5.3.1]-30 0 dTMP kinase [EC:2.7.4.9]-01 0.01 MSHA biogenesis protein MshQ-08 0 large subunit ribosomal protein L20-01 0.01 stringent starvation protein A-30 0 5-aminolevulinate synthase [EC:2.3.1.37]-30 0 malate dehydrogenase (quinone) [EC:1.1.5.4]-30 0 6-phosphogluconolactonase [EC:3.1.1.31]-30 0 large subunit ribosomal protein L15e-08 0 AP-3 complex subunitFor beta-08 Peer Review Only 0 simple sugar transport system permease protein-01 0.01 coniferyl-aldehyde dehydrogenase [EC:1.2.1.68]-01 0 antiviral helicase SKI2 [EC:3.6.1.-]-30 0 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16-30 0 folylpolyglutamate synthase [EC:6.3.2.17]-30 0 hypoxia up-regulated 1-30 0 preprotein translocase subunit SecB-30 0 lanosterol synthase [EC:5.4.99.7]-08 0 molybdate transport system substrate-binding protein-30 0 linalool 8-monooxygenase [EC:1.14.99.28]-08 0 DNA damage-binding protein 1-30 0 cell division inhibitor SepF-08 0 two-component system; sensor histidine kinase FlrB [EC:2.7.13.3]-30 0 N-acetylmuramic acid 6-phosphate etherase [EC:4.2.-.-]-30 0 chromatin assembly factor 1 subunit B-30 0 small subunit ribosomal protein S17-30 0 replication factor C subunit 3/5-30 0 translation initiation factor eIF-3 subunit P135-30 0 phenylacetic acid degradation protein-01 0.01 mevalonate kinase [EC:2.7.1.36]-30 0 phycocyanobilin:ferredoxin oxidoreductase [EC:1.3.7.5]-08 0 type IV pilus assembly protein PilQ-01 0.01 MSHA biogenesis protein MshL-30 0 peptidyl-tRNA hydrolase; PTH2 family [EC:3.1.1.29]-30 0 flagellar basal-body rod modification protein FlgD-08 0.01 molybdopterin biosynthesis protein MoeB-30 0 glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]-08 0 cell division cycle 14 [EC:3.1.3.48]-08 0 holliday junction DNA helicase RuvA-01 0.01 HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]-08 0 glucosamine-6-phosphate deaminase [EC:3.5.99.6]-01 0 glutamyl-tRNA(Gln) amidotransferase subunit E [EC:6.3.5.7]-08 0 CpeT protein-08 0 two-component system; OmpR family; sensor histidine kinase PhoQ-30 0 two-component system; NtrC family; C4-dicarboxylate transport sensor-30 0 regulatory protein-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 674 of 848

phosphatidylserine synthase [EC:2.7.8.8]-30 0 isopentenyl-diphosphate delta-isomerase [EC:5.3.3.2]-01 0 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43-08 0 bifunctional aspartokinase/homoserine dehydrogenase 1 [EC:2.7.2.4-01 0.01 aminobenzoyl-glutamate transport protein-08 0 putative iron-regulated protein-30 0 AP-2 complex subunit mu-1-30 0 protein phosphatase 2 (formerly 2A); regulatory subunit A-30 0 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]-01 0 undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase-08 0 queuosine biosynthesisFor protein QueC-01Peer Review Only0.01 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-30 0 kynurenine 3-monooxygenase [EC:1.14.13.9]-30 0 cystathionine beta-synthase [EC:4.2.1.22]-01 0.01 pre-mRNA-splicing factor CWC22-08 0 succinylglutamate desuccinylase [EC:3.5.1.96]-08 0 propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]-01 0.01 molecular chaperone IbpA-30 0 lactose/L-arabinose transport system permease protein-30 0 cystathionine gamma-synthase [EC:2.5.1.48]-01 0 5'-3' exoribonuclease 1 [EC:3.1.13.-]-30 0 5-aminolevulinate synthase [EC:2.3.1.37]-01 0 histone H4-08 0 splicing factor 3B subunit 4-08 0 myo-inositol 2-dehydrogenase [EC:1.1.1.18]-01 0.01 phospholipid-translocating ATPase [EC:3.6.3.1]-30 0.01 N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]-01 0 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]-30 0 UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]-01 0.01 UDP-galactopyranose mutase [EC:5.4.99.9]-08 0 116 kDa U5 small nuclear ribonucleoprotein component-30 0 glucose repression mediator protein-08 0 transcription elongation factor S-II-08 0 erythrocyte membrane protein 1-30 0 tripeptide aminopeptidase [EC:3.4.11.4]-01 0 saccharopine dehydrogenase (NAD+; L-glutamate forming) [EC:1.5.1.9]-08 0 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) [EC:3.6.1.41]-01 0 mercuric ion transport protein-08 0 DNA polymerase II [EC:2.7.7.7]-01 0 chloride channel protein; CIC family-01 0 threonine 3-dehydrogenase [EC:1.1.1.103]-30 0 ribosomal large subunit pseudouridine synthase B [EC:5.4.99.12]-01 0.01 splicing factor 3A subunit 1-08 0 acyl-CoA thioesterase YciA [EC:3.1.2.-]-08 0 DNA polymerase zeta subunit [EC:2.7.7.7]-08 0 phosphatidylinositol glycan; class M [EC:2.4.1.-]-08 0 DeoR family transcriptional regulator; ulaG and ulaABCDEF operon-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 675 of 848

tryptophan 2;3-dioxygenase [EC:1.13.11.11]-01 0 small subunit ribosomal protein S16-01 0.01 PKHD-type hydroxylase [EC:1.14.11.-]-08 0 chloride channel protein; CIC family-30 0 kinetochore protein NDC80-30 0 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate-30 0 myosin heavy chain-30 0 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]-30 0 Na+:H+ antiporter; NhaB family-30 0 simple sugar transport system ATP-binding protein [EC:3.6.3.17]-01 0.01 AMP nucleosidase [EC:3.2.2.4]-01For Peer Review Only 0 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]-01 0 type IV pilus assembly protein PilC-01 0.01 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]-30 0 aldose 1-epimerase [EC:5.1.3.3]-30 0 erythronate-4-phosphate dehydrogenase [EC:1.1.1.290]-30 0 TdcF protein-30 0 isocitrate dehydrogenase kinase/phosphatase [EC:2.7.11.5 3.1.3.-]-30 0 serine palmitoyltransferase [EC:2.3.1.50]-30 0 rRNA (guanine-N1-)-methyltransferase [EC:2.1.1.51]-30 0 periplasmic nitrate reductase NapA [EC:1.7.99.4]-30 0 large subunit ribosomal protein L30-08 0.01 D-xylose transport system permease protein-30 0 large subunit ribosomal protein L22-01 0.01 cytochrome c-30 0 large subunit ribosomal protein L31-01 0.01 AmpD protein-30 0 lipopolysaccharide export system protein LptC-08 0.01 putative endopeptidase [EC:3.4.24.-]-01 0 RNA polymerase sigma-70 factor; ECF subfamily-01 0.01 pre-mRNA-processing factor 6-30 0 histone deacetylase 6/10 [EC:3.5.1.98]-08 0 small subunit ribosomal protein S18-01 0.01 crotonobetaine/carnitine-CoA ligase [EC:6.2.1.-]-08 0 aerotaxis receptor-30 0 L-fucose mutarotase [EC:5.1.3.-]-08 0 ubiquitin carboxyl-terminal hydrolase 9/24 [EC:3.1.2.15]-30 0 general secretion pathway protein C-30 0 indolepyruvate ferredoxin oxidoreductase; alpha subunit [EC:1.2.7.8]-08 0 cytochrome c-type biogenesis protein CcmH-01 0.01 MFS transporter; PPP family; 3-phenylpropionic acid transporter-30 0 dynein heavy chain 2; cytosolic-08 0 phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19]-01 0.01 Cu2+-exporting ATPase [EC:3.6.3.4]-01 0 large subunit ribosomal protein L32-01 0.01 protein phosphatase 2 (formerly 2A); catalytic subunit [EC:3.1.3.16]-30 0 Fur family transcriptional regulator; iron response regulator-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 676 of 848

26S proteasome regulatory subunit N5-08 0 26S proteasome regulatory subunit N1-30 0 16S rRNA processing protein RimM-01 0.01 ATP-dependent helicase Lhr and Lhr-like helicase [EC:3.6.1.-]-01 0 glutaredoxin 3-01 0.01 nitric-oxide reductase NorQ protein [EC:1.7.99.7]-01 0 alpha-1;2-mannosyltransferase [EC:2.4.1.-]-30 0 carotenoid isomerase [EC:5.-.-.-]-08 0 cyclohexadienyl dehydrogenase [EC:1.3.1.43]-08 0 F-type H+-transporting ATPase subunit epsilon [EC:3.6.3.14]-01 0.01 F420-0:gamma-glutamylFor ligase [EC:6.3.2.-]-08Peer Review Only 0 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase-01 0 5-deoxy-glucuronate isomerase [EC:5.3.1.-]-01 0 ATP:ADP antiporter; AAA family-08 0 T-complex protein 1 subunit epsilon-08 0 colanic acid biosynthesis glycosyl transferase WcaI-08 0 NADH dehydrogenase I subunit 6 [EC:1.6.5.3]-08 0 molybdenum cofactor biosynthesis protein E-30 0 AP-1 complex subunit beta-1-30 0 V-type H+-transporting ATPase subunit C [EC:3.6.3.14]-30 0 inosose dehydratase [EC:4.2.1.44]-30 0 phosphate transport system protein-30 0 D-cysteine desulfhydrase [EC:4.4.1.15]-01 0 tryptophan 2;3-dioxygenase [EC:1.13.11.11]-30 0 centromeric protein E-30 0 structural maintenance of chromosome 2-30 0 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl-30 0 anaerobic dimethyl sulfoxide reductase [EC:1.8.99.-]-08 0 homogentisate 1;2-dioxygenase [EC:1.13.11.5]-01 0.01 2-octaprenyl-3-methyl-6-methoxy-1;4-benzoquinol hydroxylase-01 0 beta-1;4-mannosyltransferase [EC:2.4.1.142]-08 0 ferredoxin; 2Fe-2S-01 0.01 DNA-directed RNA polymerase subunit A" [EC:2.7.7.6]-08 0 small subunit ribosomal protein S6-01 0.01 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase-01 0.01 dipeptide transport system permease protein-30 0 two-component system; cell cycle response regulator CtrA-08 0 dynein intermediate chain 2; axonemal-08 0 ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]-01 0 alkanesulfonate monooxygenase [EC:1.14.14.5]-30 0 O-antigen biosynthesis protein WbqP-08 0 guanine deaminase [EC:3.5.4.3]-01 0 T-complex protein 1 subunit alpha-30 0 carbonyl reductase (NADPH) [EC:1.1.1.184]-08 0 leukotriene-A4 hydrolase [EC:3.3.2.6]-30 0 glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]-30 0 minichromosome maintenance protein 3-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 677 of 848

dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]-30 0 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]-01 0.01 photosynthetic reaction center L subunit-08 0 dynein heavy chain 1; cytosolic-08 0 ubiquitin-conjugating enzyme (huntingtin interacting protein 2)-08 0 serine protease SohB [EC:3.4.21.-]-30 0 histone acetyltransferase [EC:2.3.1.48]-30 0 endoglucanase [EC:3.2.1.4]-08 0 flagella basal body P-ring formation protein FlgA-08 0 LemA protein-30 0 peptidyl-prolyl cis-transFor isomerase-like Peer 4 [EC:5.2.1.8]-30 Review Only 0 V-type H+-transporting ATPase subunit A [EC:3.6.3.14]-30 0 mevalonate kinase [EC:2.7.1.36]-01 0 elongator complex protein 3 [EC:2.3.1.48]-08 0 succinate dehydrogenase (ubiquinone) iron-sulfur protein-30 0 molybdate transport system permease protein-01 0 general secretion pathway protein E-01 0.01 TdcF protein-01 0.01 ornithine carbamoyltransferase [EC:2.1.3.3]-30 0 general secretion pathway protein K-30 0 bacterioferritin-30 0 copper resistance protein B-30 0 dynein light intermediate chain; axonemal-30 0 phosphate transport system permease protein-01 0 exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]-30 0 periplasmic protein TorT-01 0 phosphoserine phosphatase [EC:3.1.3.3]-01 0 T-complex protein 1 subunit delta-30 0 nitric oxide dioxygenase [EC:1.14.12.17]-08 0 T-complex protein 1 subunit alpha-08 0 insulysin [EC:3.4.24.56]-08 0 V-type H+-transporting ATPase subunit D [EC:3.6.3.14]-08 0 heat shock protein HspQ-30 0 arginine:pyruvate transaminase [EC:2.6.1.84]-30 0 tagatose 6-phosphate kinase [EC:2.7.1.144]-08 0 NADH dehydrogenase I subunit C [EC:1.6.5.3]-30 0 glucokinase [EC:2.7.1.2]-01 0.01 carbon-monoxide dehydrogenase small subunit [EC:1.2.99.2]-30 0 tRNA (adenine-N1-)-methyltransferase [EC:2.1.1.36]-08 0 ribosome-binding factor A-01 0.01 adenosylcobinamide kinase / adenosylcobinamide-phosphate-30 0 phenylacetate-CoA ligase [EC:6.2.1.30]-30 0 precorrin-6A synthase [EC:2.1.1.152]-08 0 ATP-dependent RNA helicase DDX41 [EC:3.6.1.-]-30 0 casein kinase 2; beta polypeptide-08 0 molybdopterin-guanine dinucleotide biosynthesis protein A-30 0 putative biotin biosynthesis protein BioY-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 678 of 848

putative spermidine/putrescine transport system ATP-binding protein-01 0.01 delta12-fatty acid dehydrogenase [EC:1.14.99.33]-08 0 calcium-dependent protein kinase [EC:2.7.11.1]-30 0 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]-01 0 magnesium chelatase subunit I [EC:6.6.1.1]-01 0.01 RNA methyltransferase; TrmH family; group 2 [EC:2.1.1.-]-01 0.01 antibiotic transport system permease protein-01 0.01 5-dehydro-2-deoxygluconokinase [EC:2.7.1.92]-30 0 conjugal transfer ATP-binding protein TraC-30 0 protocatechuate 3;4-dioxygenase; beta subunit [EC:1.13.11.3]-08 0 electron transport complexFor protein Peer RnfG-30 Review Only 0 20S proteasome subunit beta 2 [EC:3.4.25.1]-30 0 2-oxoisovalerate dehydrogenase E1 component; beta subunit-30 0 minichromosome maintenance protein 4 (cell division control protein-30 0 5-oxoprolinase (ATP-hydrolysing) [EC:3.5.2.9]-01 0.01 exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]-01 0 hemolysin III-30 0 large subunit ribosomal protein L36-30 0 cyclin B-30 0 hydroxyacylglutathione hydrolase [EC:3.1.2.6]-01 0.01 UMP-CMP kinase [EC:2.7.4.- 2.7.4.14]-30 0 acyl-CoA oxidase [EC:1.3.3.6]-30 0 sigma-E factor negative regulatory protein RseC-08 0 putative sigma-54 modulation protein-01 0 ribosomal RNA large subunit methyltransferase F [EC:2.1.1.48]-30 0 photosystem II PsbK protein-30 0 tRNA (guanosine-2'-O-)-methyltransferase [EC:2.1.1.34]-30 0 cell division topological specificity factor-08 0 dihydropyrimidinase [EC:3.5.2.2]-01 0.01 CRP/FNR family transcriptional regulator; anaerobic regulatory-30 0 alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]-30 0 N-acylneuraminate cytidylyltransferase [EC:2.7.7.43]-01 0.01 stress-induced-phosphoprotein 1-30 0 adenine deaminase [EC:3.5.4.2]-30 0 sarcosine oxidase; subunit delta [EC:1.5.3.1]-01 0.01 large subunit ribosomal protein L24-30 0 amyloid beta precursor protein binding protein 1-08 0 flagellar basal-body rod modification protein FlgD-30 0 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5]-30 0 elongator complex protein 3 [EC:2.3.1.48]-30 0 glucose-6-phosphate 1-epimerase [EC:5.1.3.15]-08 0 carboxylesterase type B [EC:3.1.1.1]-01 0 uridine kinase [EC:2.7.1.48]-30 0 alpha-L-fucosidase [EC:3.2.1.51]-30 0 8-amino-7-oxononanoate synthase [EC:2.3.1.47]-01 0 indolepyruvate ferredoxin oxidoreductase [EC:1.2.7.8]-01 0.01 ATP-binding cassette; sub-family F; member 2-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 679 of 848

chalcone synthase [EC:2.3.1.74]-30 0 E3 ubiquitin-protein ligase HUWE1 [EC:6.3.2.19]-08 0 type IV pilus assembly protein PilF-08 0 pyrimidine-nucleoside phosphorylase [EC:2.4.2.2]-08 0 lipopolysaccharide transport system ATP-binding protein-08 0 proline dehydrogenase [EC:1.5.99.8]-08 0.01 helicase [EC:3.6.1.-]-08 0 histone H2B-08 0 ATP-dependent RNA helicase DDX6/DHH1 [EC:3.6.1.-]-08 0 fatty acid desaturase (delta-4 desaturase) [EC:1.14.19.-]-30 0 aminocarboxymuconate-semialdehydeFor Peer decarboxylase Review [EC:4.1.1.45]-08 Only 0 thiol:disulfide interchange protein DsbA-30 0 tRNA pseudouridine synthase C [EC:5.4.99.12]-30 0 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]-30 0 flagellar biosynthesis protein FlhA-01 0.01 heptosyltransferase II [EC:2.4.-.-]-08 0 UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl 1-P-08 0 naphthoate synthase [EC:4.1.3.36]-30 0 STE24 endopeptidase [EC:3.4.24.84]-30 0 NADH dehydrogenase I subunit K [EC:1.6.5.3]-01 0.01 aromatic-amino-acid transaminase [EC:2.6.1.57]-30 0 methylmalonyl-CoA epimerase [EC:5.1.99.1]-08 0 DNA excision repair protein ERCC-2 [EC:3.6.1.-]-08 0 MSHA pilin protein MshC-08 0 chorismate mutase [EC:5.4.99.5]-30 0 thiol:disulfide interchange protein DsbC [EC:5.3.4.1]-01 0 biotin biosynthesis protein BioH-01 0 diphosphomevalonate decarboxylase [EC:4.1.1.33]-01 0 small subunit ribosomal protein S4e-08 0 molybdopterin-guanine dinucleotide biosynthesis protein A-01 0.01 trimethylamine-N-oxide reductase (cytochrome c) 2 [EC:1.7.2.3]-30 0 Fe/S biogenesis protein NfuA-01 0 large subunit ribosomal protein L32-30 0 large subunit ribosomal protein L5e-30 0 protocatechuate 4;5-dioxygenase; beta chain [EC:1.13.11.8]-08 0 Ca2+ transporting ATPase; plasma membrane [EC:3.6.3.8]-08 0 minichromosome maintenance protein 5 (cell division control protein-08 0 SprT protein-08 0 peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]-08 0 dolichol-phosphate mannosyltransferase [EC:2.4.1.83]-30 0 penicillin-binding protein 1B [EC:2.4.1.129 3.4.-.-]-01 0 peptide chain release factor eRF subunit 1-30 0 electron transport complex protein RnfB-01 0.01 ribonuclease PH [EC:2.7.7.56]-01 0.01 sigma-54 specific transcriptional regulator; flagellar regulatory-30 0 ATP citrate (pro-S)-lyase [EC:2.3.3.8]-30 0 DNA repair protein REV1 [EC:2.7.7.-]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 680 of 848

LacI family transcriptional regulator; gluconate utilization system-30 0 cb-type cytochrome c oxidase subunit II [EC:1.9.3.1]-08 0 DNA polymerase zeta subunit [EC:2.7.7.7]-30 0 glycerate kinase [EC:2.7.1.31]-01 0 peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]-08 0 alpha 1;3-glucosidase [EC:3.2.1.84]-30 0 glutamate carboxypeptidase [EC:3.4.17.11]-30 0 transcription elongation regulator 1-08 0 kinesin family member 6/9-08 0 NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:1.6.5.3 1.6.99.3]-08 0 acetoacetyl-CoA reductaseFor [EC:1.1.1.36]-30 Peer Review Only 0 MSHA pilin protein MshD-08 0 ATP-dependent RNA helicase DDX46/PRP5 [EC:3.6.1.-]-08 0 ElaA protein-08 0 neopullulanase [EC:3.2.1.135]-08 0 preprotein translocase subunit SecB-01 0.01 anaerobic nitric oxide reductase transcription regulator-30 0 photosystem II Psb27 protein-08 0 ATP-dependent RNA helicase [EC:3.6.1.-]-08 0 molybdate transport system permease protein-30 0 MSHA biogenesis protein MshM-30 0 phenylacetic acid degradation NADH oxidoreductase-01 0 alanine transaminase [EC:2.6.1.2]-08 0 N-acetylornithine carbamoyltransferase [EC:2.1.3.9]-08 0 pre-mRNA-splicing factor CDC5/CEF1-08 0 glutamine amidotransferase [EC:2.4.2.-]-30 0 xylose isomerase [EC:5.3.1.5]-01 0 AP-2 complex subunit mu-1-08 0 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]-30 0 integrator complex subunit 1-30 0 dTDP-4-dehydrorhamnose 3;5-epimerase [EC:5.1.3.13]-01 0.01 cupin 2 domain-containing protein-08 0 phenylalanine-4-hydroxylase [EC:1.14.16.1]-30 0 histone H3-30 0 aminoacylase [EC:3.5.1.14]-30 0 (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase [EC:5.4.99.15]-30 0 mandelate racemase [EC:5.1.2.2]-30 0 ABC-2 type transport system ATP-binding protein-01 0.01 beta-catenin-like protein 1-08 0 ubiquitin carboxyl-terminal hydrolase 4/11/15 [EC:3.1.2.15]-30 0 membrane dipeptidase [EC:3.4.13.19]-08 0 acyl-CoA thioesterase II [EC:3.1.2.-]-01 0 protein PsiE-01 0.01 trans-2-enoyl-CoA reductase (NAD+) [EC:1.3.1.44]-08 0 two-component system; NtrC family; sensor kinase [EC:2.7.13.3]-08 0 2-hydroxy-3-oxopropionate reductase [EC:1.1.1.60]-30 0 bacterioferritin-01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 681 of 848

NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]-30 0 para-aminobenzoate synthetase component II [EC:2.6.1.85]-30 0 ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.1.-]-30 0 CDP-glucose 4;6-dehydratase [EC:4.2.1.45]-01 0.01 paraquat-inducible protein B-30 0 tRNA-dihydrouridine synthase C [EC:1.-.-.-]-30 0 sulfonate/nitrate/taurine transport system permease protein-01 0.01 2-methylcitrate synthase [EC:2.3.3.5]-01 0.01 ubiquitin-like 1-activating enzyme E1 B [EC:6.3.2.19]-08 0 protein transport protein SEC61 subunit alpha-30 0 maleylacetoacetate Forisomerase [EC:5.2.1.2]-30Peer Review Only 0 Bax protein-01 0 multiple antibiotic resistance protein-30 0 Rrf2 family transcriptional regulator; iron-sulfur cluster assembly-30 0 peptidyl-prolyl cis-trans isomerase-like 4 [EC:5.2.1.8]-08 0 xanthine dehydrogenase YagR molybdenum-binding subunit [EC:1.17.1.4]-30 0 beta-aspartyl-dipeptidase (metallo-type) [EC:3.4.19.-]-08 0 V-type H+-transporting ATPase subunit C [EC:3.6.3.14]-08 0 carbon starvation protein-30 0 transcriptional adapter 2-alpha-30 0 type VI secretion system protein VasG-30 0 threonine 3-dehydrogenase [EC:1.1.1.103]-01 0 kelch-like protein 18-08 0 thiosulfate sulfurtransferase [EC:2.8.1.1]-30 0 methylglyoxal synthase [EC:4.2.3.3]-30 0 nuclear factor of activated T-cells; cytoplasmic;-30 0 Rieske 2Fe-2S family protein-08 0 dTDP-4-dehydrorhamnose 3;5-epimerase [EC:5.1.3.13]-30 0 cytochrome P450; family 51 (sterol 14-demethylase) [EC:1.14.13.70]-30 0 lysine decarboxylase [EC:4.1.1.18]-08 0 translation initiation factor eIF-4A-08 0 type IV pilus assembly protein PilB-01 0.01 pyrroloquinoline-quinone synthase [EC:1.3.3.11]-08 0 NADH dehydrogenase I subunit C/D [EC:1.6.5.3]-01 0 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19]-08 0 sec-independent protein translocase protein TatA-30 0 V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14]-08 0 CDP-6-deoxy-D-xylo-4-hexulose-3-dehydrase-01 0.01 large subunit ribosomal protein L34-01 0.01 phosphoribosylanthranilate isomerase [EC:5.3.1.24]-30 0 L-rhamnose mutarotase [EC:5.1.3.-]-08 0 FMN-dependent NADH-azoreductase [EC:1.7.-.-]-01 0.01 kinesin family member 4/7/21/27-30 0 molybdopterin oxidoreductase; membrane subunit [EC:1.2.7.-]-30 0 small subunit ribosomal protein S20-01 0.01 type IV pilus assembly protein PilO-08 0 lipoprotein NlpD-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 682 of 848

shikimate kinase [EC:2.7.1.71]-30 0 LysR family transcriptional regulator; positive regulator for ilvC-30 0 basic membrane protein A and related proteins-30 0 cobalamin biosynthesis protein CbiD-30 0 endoglucanase [EC:3.2.1.4]-30 0 thiamine transport system substrate-binding protein-30 0 Lrp/AsnC family transcriptional regulator; leucine-responsive-01 0 photosystem II PsbH protein-08 0 zinc transport system permease protein-30 0 cAMP-dependent protein kinase regulator-30 0.01 sec-independent proteinFor translocase Peer protein TatA-01 Review Only0.01 uridine kinase [EC:2.7.1.48]-01 0 DNA excision repair protein ERCC-3 [EC:3.6.1.-]-08 0 two-component system; NtrC family; response regulator PilR-08 0 ATP-dependent helicase HrpB [EC:3.6.1.-]-01 0 C4-dicarboxylate transporter; DctM subunit-30 0 acetolactate decarboxylase [EC:4.1.1.5]-08 0 nicotinamide mononucleotide transporter-01 0 ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.1.2.15]-08 0 small subunit ribosomal protein S2e-08 0 NADH dehydrogenase I subunit A [EC:1.6.5.3]-30 0 spermidine/putrescine transport system permease protein-08 0 serine-threonine kinase receptor-associated protein-08 0 FMN-dependent NADH-azoreductase [EC:1.7.-.-]-30 0 electron transport complex protein RnfC-01 0 V-type H+-transporting ATPase subunit E [EC:3.6.3.14]-30 0 two-component system; cell cycle response regulator-08 0 RNA methyltransferase; TrmH family-01 0 D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]-01 0 SH3 domain protein-08 0 outer membrane lipoprotein SlyB-08 0 homogentisate solanesyltransferase-30 0 translation initiation factor eIF-2 gamma subunit-30 0 sphinganine-1-phosphate aldolase [EC:4.1.2.27]-08 0 AP-1 complex subunit mu-30 0 MFS transporter; OPA family; solute carrier family 37-08 0 manganese/zinc/iron transport system substrate-binding protein-08 0 20S proteasome subunit alpha 6 [EC:3.4.25.1]-30 0 D-alanine transaminase [EC:2.6.1.21]-30 0 ataxia telangectasia mutated family protein [EC:2.7.11.1]-30 0 phosphonoacetate hydrolase [EC:3.11.1.2]-01 0 stringent starvation protein B-30 0 dimethylargininase [EC:3.5.3.18]-01 0 homeobox protein cut-like-08 0 YggT family protein-01 0.01 spermidine/putrescine transport system substrate-binding protein-08 0 putative two-component system response regulator-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 683 of 848

S-phase kinase-associated protein 1-30 0 ribose 5-phosphate isomerase B [EC:5.3.1.6]-01 0.01 fructose transport system ATP-binding protein-08 0 mannosyl-3-phosphoglycerate phosphatase [EC:3.1.3.70]-30 0 urea carboxylase [EC:6.3.4.6]-30 0 uracil phosphoribosyltransferase [EC:2.4.2.9]-30 0 phosphatidylglycerophosphatase A [EC:3.1.3.27]-30 0 NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:1.6.5.3 1.6.99.3]-08 0 CCR4-NOT transcription complex subunit 3-08 0 minichromosome maintenance protein 7 (cell division control protein-30 0 citryl-CoA lyase [EC:4.1.3.34]-30For Peer Review Only 0 succinate dehydrogenase (ubiquinone) flavoprotein subunit-08 0 mitogen-activated protein kinase [EC:2.7.11.24]-30 0 5'-AMP-activated protein kinase; catalytic alpha subunit-08 0 UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]-08 0 dipeptidyl-peptidase III [EC:3.4.14.4]-01 0 pilus assembly protein CpaF-08 0 LAO/AO transport system kinase [EC:2.7.-.-]-01 0 DnaA-homolog protein-01 0 spermidine dehydrogenase [EC:1.5.99.6]-01 0 membrane protein required for colicin V production-01 0.01 biotin synthesis protein BioC-01 0 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5]-30 0 2-hydroxy-3-oxopropionate reductase [EC:1.1.1.60]-01 0.01 protein phosphatase [EC:3.1.3.16]-30 0 D-cysteine desulfhydrase [EC:4.4.1.15]-30 0 aminoacylhistidine dipeptidase [EC:3.4.13.3]-30 0 allophycocyanin alpha subunit-08 0 26S proteasome regulatory subunit T2-30 0 AMP deaminase [EC:3.5.4.6]-30 0 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4]-01 0 large subunit ribosomal protein L22e-08 0 unspecific monooxygenase [EC:1.14.14.1]-30 0 methoxyneurosporene dehydrogenase [EC:1.14.99.-]-08 0 anaphase-promoting complex subunit 2-30 0 E1A-binding protein p400 [EC:3.6.1.-]-30 0 multicomponent K+:H+ antiporter subunit D-30 0 20S proteasome subunit beta 1 [EC:3.4.25.1]-08 0 outer membrane factor; OMF family-08 0 flagellar biosynthesis protein-08 0 starvation-inducible DNA-binding protein-30 0 saccharopine dehydrogenase (NADP+; L-glutamate forming)-08 0 nitronate monooxygenase [EC:1.13.12.16]-30 0 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]-01 0.01 ATP-dependent RNA helicase DDX27 [EC:3.6.1.-]-08 0 tRNA (guanine-N2-)-methyltransferase [EC:2.1.1.32]-30 0 cytochrome b6-f complex iron-sulfur subunit [EC:1.10.99.1]-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 684 of 848

AMP deaminase [EC:3.5.4.6]-08 0 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]-01 0.01 chromate transporter-30 0 anaphase-promoting complex subunit 1-08 0 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate-30 0 UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]-30 0 membrane fusion protein-30 0 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [EC:1.2.1.-]-30 0 DnaJ homolog subfamily C member 2-08 0 NAD(P) transhydrogenase [EC:1.6.1.1]-01 0 type IV pilus assemblyFor protein PilM-30Peer Review Only 0 arabinogalactan endo-1;4-beta-galactosidase [EC:3.2.1.89]-08 0 membrane-bound lytic murein transglycosylase A [EC:3.2.1.-]-30 0 integration host factor subunit beta-30 0 T-complex protein 1 subunit theta-08 0 CRP/FNR family transcriptional regulator; cyclic AMP receptor-30 0 carnitinyl-CoA dehydratase [EC:4.2.1.-]-30 0 glycolate oxidase FAD binding subunit-30 0 biotin biosynthesis protein BioH-08 0 UDP-N-acetylglucosamine pyrophosphorylase [EC:2.7.7.23]-30 0 lactoylglutathione lyase [EC:4.4.1.5]-30 0 succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]-08 0 runt-related transcription factor 2-30 0 putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]-01 0.01 CDP-6-deoxy-D-xylo-4-hexulose-3-dehydrase-30 0 glycylpeptide N-tetradecanoyltransferase [EC:2.3.1.97]-08 0 tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]-30 0 sugar fermentation stimulation protein A-01 0.01 two-component system; OmpR family; heavy metal sensor histidine-30 0 Smg protein-08 0 IclR family transcriptional regulator; mhp operon transcriptional-08 0 histone acetyltransferase MYST1 [EC:2.3.1.48]-30 0 DNA ligase 1 [EC:6.5.1.1]-08 0 Lrp/AsnC family transcriptional regulator-01 0 ADP-ribose diphosphatase [EC:3.6.1.-]-08 0 ApaG protein-01 0 cytochrome c-type biogenesis protein-30 0 pyridoxine kinase [EC:2.7.1.35]-08 0 iduronate 2-sulfatase [EC:3.1.6.13]-30 0 AP-1 complex subunit gamma-1-08 0 pyrroloquinoline quinone biosynthesis protein E-30 0 glutaminase [EC:3.5.1.2]-30 0 feruloyl-CoA synthase [EC:6.2.1.34]-08 0 Na+-transporting NADH:ubiquinone oxidoreductase subunit C-01 0 DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]-30 0 ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]-01 0 serine protease DegS [EC:3.4.21.-]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 685 of 848

large conductance mechanosensitive channel; MscL family-08 0 monoamine oxidase [EC:1.4.3.4]-30 0 protoporphyrinogen oxidase [EC:1.3.3.4]-01 0.01 small subunit ribosomal protein S6e-08 0 arsenite-transporting ATPase [EC:3.6.3.16]-08 0 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]-30 0 phosphatidylinositol 4-kinase [EC:2.7.1.67]-08 0 26S proteasome regulatory subunit T4-30 0 pyridoxine biosynthesis protein [EC:4.-.-.-]-30 0 nitric oxide dioxygenase [EC:1.14.12.17]-30 0 DNA repair protein RadC-01For Peer Review Only 0 two-component system; NarL family; sensor histidine kinase UhpB-08 0 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP-30 0 L-idonate 5-dehydrogenase [EC:1.1.1.264]-30 0 ATP adenylyltransferase [EC:2.7.7.53]-08 0 pre-mRNA-splicing factor SYF1-30 0 5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10]-08 0 lactate transporter; LctP family-30 0 calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17]-08 0 mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]-30 0 nuclear receptor; other families; insect-08 0 uncharacterized zinc-type alcohol dehydrogenase-like protein-08 0 fused [EC:2.7.11.1]-30 0 UDP-glucose:(heptosyl)LPS alpha-1;3-glucosyltransferase [EC:2.4.1.-]-08 0 E3 ubiquitin-protein ligase NEDD4 [EC:6.3.2.19]-08 0 capsular polysaccharide transport system permease protein-30 0 MSHA biogenesis protein MshE-30 0 aldehyde reductase [EC:1.1.1.21]-08 0 photosystem II PsbY protein-08 0 alkane 1-monooxygenase [EC:1.14.15.3]-30 0 AmpE protein-30 0 metal ion transporter; MIT family-08 0 cytochrome c biogenesis protein CcmG; thiol:disulfide interchange-30 0 tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase-30 0 type IV pilus assembly protein PilE-08 0 putative N6-adenine-specific DNA methylase-01 0 26S proteasome regulatory subunit N10-30 0 ribose 5-phosphate isomerase B [EC:5.3.1.6]-30 0 ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]-30 0 death on curing protein-08 0 minichromosome maintenance protein 9-30 0 zinc transport system ATP-binding protein [EC:3.6.3.-]-30 0 protein geranylgeranyltransferase type II [EC:2.5.1.60]-30 0 ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14]-08 0 26S proteasome regulatory subunit T6-08 0 phosphoribosylamine--glycine ligase / phosphoribosylglycinamide-08 0 ATP-dependent Clp protease adaptor protein ClpS-01 0

Wiley-Blackwell and Society for Applied Microbiology Page 686 of 848

26S proteasome regulatory subunit N3-08 0 cobalt/nickel transport system ATP-binding protein-30 0 Fur family transcriptional regulator; zinc uptake regulator-30 0 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis-08 0 TetR/AcrR family transcriptional regulator-01 0 DNA topoisomerase VI subunit B [EC:5.99.1.3]-30 0 putative glutamine transport system ATP-binding protein [EC:3.6.3.-]-08 0 ATP-independent RNA helicase DbpA-01 0 aminoacylase [EC:3.5.1.14]-08 0 SCY1-like-30 0 2-haloacid dehalogenaseFor [EC:3.8.1.2]-30 Peer Review Only 0 type I restriction enzyme M protein [EC:2.1.1.72]-01 0.01 two-component system; NtrC family; sensor histidine kinase PilS-08 0 tryptophan-rich sensory protein-01 0.01 putative DNA methylase-30 0 glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]-08 0 ferredoxin--NAD+ reductase [EC:1.18.1.3]-08 0 sulfite dehydrogenase [EC:1.8.2.1]-08 0 heme exporter protein B-01 0.01 S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase-01 0 dicarboxylate/amino acid:cation (Na+ or H+) symporter; DAACS family-30 0 sodium transport system permease protein-30 0 molybdenum cofactor biosynthesis protein C-01 0.01 lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]-01 0 small subunit ribosomal protein S8e-08 0 Fis family transcriptional regulator; factor for inversion-08 0 Icc protein-01 0 N-acetylgalactosamine-6-sulfatase [EC:3.1.6.4]-08 0 acetyl-/propionyl-CoA carboxylase; biotin carboxylase; biotin-08 0 tubulin gamma-30 0 translation initiation factor eIF-3 subunit 9-08 0 UDP-N-acetyl-D-glucosamine dehydrogenase [EC:1.1.1.-]-08 0 HIV Tat-specific factor 1-08 0 protein FAM50-30 0 iron complex transport system ATP-binding protein [EC:3.6.3.34]-01 0 allantoicase [EC:3.5.3.4]-01 0.01 flagellar hook-associated protein 1 FlgK-01 0 large subunit ribosomal protein L44e-08 0 dethiobiotin synthetase [EC:6.3.3.3]-01 0 type VI secretion system protein ImpK-08 0 small multidrug resistance protein; SMR family-08 0.01 two-component system; OmpR family; response regulator TctD-08 0 psp operon transcriptional activator-30 0 ubiquitin carboxyl-terminal hydrolase 36/42 [EC:3.1.2.15]-30 0 MFS transporter; FSR family; fosmidomycin resistance protein-08 0 arsenate reductase [EC:1.20.4.1]-30 0 NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:1.6.5.3 1.6.99.3]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 687 of 848

ATP-binding cassette; sub-family E; member 1-30 0 2;4-dihydroxyhept-2-ene-1;7-dioic acid aldolase [EC:4.1.2.-]-30 0 N-carbamoylsarcosine amidase [EC:3.5.1.59]-08 0 aspartate dehydrogenase [EC:1.4.1.21]-08 0 nucleobase:cation symporter-1; NCS1 family-08 0 arginine N-succinyltransferase [EC:2.3.1.109]-01 0 nitrogen regulatory protein P-II 1-30 0 polypeptide N-acetylglucosaminyltransferase [EC:2.4.1.-]-30 0 CCR4-NOT transcription complex subunit 4 [EC:6.3.2.19]-08 0 DNA-3-methyladenine glycosylase I [EC:3.2.2.20]-01 0 dihydroorotate dehydrogenaseFor electronPeer transfer Reviewsubunit-01 Only 0 homocysteine S-methyltransferase [EC:2.1.1.10]-01 0.01 sigma-E factor negative regulatory protein RseA-08 0 LPS-assembly lipoprotein-08 0 type II pantothenate kinase [EC:2.7.1.33]-08 0 15;16-dihydrobiliverdin:ferredoxin oxidoreductase [EC:1.3.7.2]-08 0 ATP-dependent RNA helicase DDX27 [EC:3.6.1.-]-30 0 proteasome alpha subunit [EC:3.4.25.1]-08 0 protocatechuate 3;4-dioxygenase; alpha subunit [EC:1.13.11.3]-08 0 copper homeostasis protein-08 0 pre-mRNA-processing factor SLU7-30 0 minichromosome maintenance protein 7 (cell division control protein-08 0 two-component system; NtrC family; C4-dicarboxylate transport sensor-01 0 MFS transporter; DHA1 family; tetracycline resistance protein-30 0 anaerobic dimethyl sulfoxide reductase subunit C (DMSO reductase-30 0 histone H2B-30 0 small subunit ribosomal protein S3Ae-08 0 erythronolide synthase [EC:2.3.1.94]-30 0 phospholipase C; delta [EC:3.1.4.11]-08 0 exosome complex exonuclease RRP6 [EC:3.1.13.-]-08 0 queuosine biosynthesis protein QueC-30 0 T-complex protein 1 subunit gamma-30 0 arginine-tRNA-protein transferase [EC:2.3.2.8]-30 0 gamma-butyrobetaine dioxygenase [EC:1.14.11.1]-01 0.01 solute carrier family 25 (mitochondrial carrier; adenine nucleotide-30 0 transcriptional regulator-30 0 Cu(I)/Ag(I) efflux system membrane protein CusA-01 0 chorismate--pyruvate lyase [EC:4.1.3.40]-01 0 ribosomal large subunit pseudouridine synthase F [EC:5.4.99.12]-30 0 arylsulfatase G [EC:3.1.6.-]-08 0 GST-like protein-01 0 oxaloacetate decarboxylase; gamma subunit [EC:4.1.1.3]-08 0 cytidine deaminase [EC:3.5.4.5]-01 0 phosphoribulokinase [EC:2.7.1.19]-30 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase /-01 0.01 RNA-binding protein PNO1-30 0 preprotein translocase subunit SecG-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 688 of 848

NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:1.6.5.3 1.6.99.3]-30 0 V-type H+-transporting ATPase 16kDa proteolipid subunit-08 0 chalcone synthase [EC:2.3.1.74]-01 0 NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:1.6.5.3 1.6.99.3]-08 0 flagellar protein FliS-30 0 ADP-ribosylglycohydrolase [EC:3.2.-.-]-30 0 glucose repression mediator protein-30 0 maltose alpha-D-glucosyltransferase [EC:5.4.99.16]-08 0 bloom syndrome protein [EC:3.6.1.-]-08 0 26S proteasome regulatory subunit N3-30 0 putative dehydrogenaseFor [EC:1.1.-.-]-08 Peer Review Only 0 nicastrin-30 0 putative sigma-54 modulation protein-30 0 mannose-6-phosphate isomerase [EC:5.3.1.8]-01 0.01 iron complex transport system substrate-binding protein-01 0 carbonic anhydrase [EC:4.2.1.1]-01 0.01 alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]-01 0 4-nitrophenyl phosphatase [EC:3.1.3.41]-30 0 2-dehydro-3-deoxygalactonokinase [EC:2.7.1.58]-01 0 carboxymethylenebutenolidase [EC:3.1.1.45]-30 0 putative endonuclease-01 0 two-component system; OmpR family; copper resistance phosphate-08 0 CysZ protein-30 0 beta-catenin-like protein 1-30 0 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase-08 0 beta-mannosidase [EC:3.2.1.25]-01 0 voltage-gated sodium channel-30 0 CD68 antigen-30 0 2-C-methyl-D-erythritol 2;4-cyclodiphosphate synthase [EC:4.6.1.12]-30 0 two-component system; OmpR family; sensor histidine kinase RstB-08 0 two-component system; OmpR family; response regulator-01 0.01 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5]-01 0 sorbitol/mannitol transport system permease protein-01 0 arsenical resistance protein ArsH-30 0 geranyl-CoA carboxylase alpha subunit [EC:6.4.1.5]-30 0 adenylate cyclase; class 1 [EC:4.6.1.1]-30 0 sarcosine dehydrogenase [EC:1.5.99.1]-01 0.01 monovalent cation:H+ antiporter-2; CPA2 family-01 0 MSHA biogenesis protein MshP-08 0 trimethylamine-N-oxide reductase (cytochrome c) 2 [EC:1.7.2.3]-01 0.01 putative chitinase-08 0 peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11-30 0 ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.1.-]-08 0 adenosylcobyric acid synthase [EC:6.3.5.10]-01 0 alpha-amylase [EC:3.2.1.1]-30 0 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30]-30 0 translation initiation factor eIF-4A 3 [EC:3.6.1.-]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 689 of 848

selenocysteine-specific elongation factor-30 0 POU domain transcription factor; class 3-30 0 cytosine deaminase [EC:3.5.4.1]-30 0 D-alanyl-D-alanine dipeptidase [EC:3.4.13.-]-30 0 cyanate lyase [EC:4.2.1.104]-08 0 DnaJ homolog subfamily A member 5-08 0 formyl-CoA transferase [EC:2.8.3.16]-30 0 MFS transporter; CP family; cyanate transporter-30 0 anaerobic nitric oxide reductase transcription regulator-08 0 large subunit ribosomal protein L3e-30 0 cytidine deaminase For[EC:3.5.4.5]-30 Peer Review Only 0 type VI secretion system protein ImpC-30 0 transcription elongation regulator 1-30 0 molybdopterin biosynthesis protein Mog-08 0 vacuolar protein sorting-associated protein 72-30 0 creatinase [EC:3.5.3.3]-01 0.01 2-dehydro-3-deoxyphosphogalactonate aldolase [EC:4.1.2.21]-01 0 flagellum-specific ATP synthase [EC:3.6.3.14]-01 0 bleomycin hydrolase [EC:3.4.22.40]-08 0 intracellular septation protein-30 0 replication factor C subunit 1-30 0 CCR4-NOT transcription complex subunit 7/8-08 0 dCMP deaminase [EC:3.5.4.12]-30 0 linoleoyl-CoA desaturase [EC:1.14.19.3]-08 0 OmpA-OmpF porin; OOP family-30 0 alkanal monooxygenase (FMN-linked) [EC:1.14.14.3]-08 0 phosphatidylinositol glycan; class A [EC:2.4.1.198]-30 0 dipeptidyl-peptidase III [EC:3.4.14.4]-30 0 manganese transport protein-30 0 CDP-4-dehydro-6-deoxyglucose reductase [EC:1.17.1.1]-01 0 thiol:disulfide interchange protein DsbA-01 0 hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88]-30 0 glycylpeptide N-tetradecanoyltransferase [EC:2.3.1.97]-30 0 exoribonuclease II [EC:3.1.13.1]-30 0 simple sugar transport system substrate-binding protein-01 0.01 exosome complex component RRP42-08 0 curli production assembly/transport component CsgG-30 0 NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:1.6.5.3 1.6.99.3]-30 0 CCR4-NOT transcription complex subunit 7/8-30 0 glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]-08 0 adenylate cyclase; class 1 [EC:4.6.1.1]-08 0 aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit C-01 0.01 sortase A-08 0 pre-mRNA-processing factor 40-08 0 Fur family transcriptional regulator; iron response regulator-30 0 vesicle-fusing ATPase [EC:3.6.4.6]-30 0 copper homeostasis protein-01 0

Wiley-Blackwell and Society for Applied Microbiology Page 690 of 848

FKBP-type peptidyl-prolyl cis-trans isomerase SlpA [EC:5.2.1.8]-30 0 collagen; type I/II/III/V/XI; alpha-08 0 protein geranylgeranyltransferase type II [EC:2.5.1.60]-08 0 transposase; IS30 family-08 0 conserved hypothetical protein-01 0.01 ubiquitin-conjugating enzyme E2 J2 [EC:6.3.2.19]-30 0 enolase-phosphatase E1 [EC:3.1.3.77]-30 0 phosphate:Na+ symporter; PNaS family-30 0 succinylarginine dihydrolase [EC:3.5.3.23]-30 0 phosphoinositide-3-kinase; regulatory subunit 4; p150 [EC:2.7.11.1]-08 0 two-component system;For OmpR family;Peer sensor histidine Review kinase CreC-01 Only 0 two-component system; OmpR family; sensor histidine kinase CpxA-30 0 mitogen-activated protein kinase [EC:2.7.11.24]-08 0 exosome complex component RRP41-08 0 exodeoxyribonuclease VII small subunit [EC:3.1.11.6]-30 0 heme exporter protein D-08 0 formyltetrahydrofolate deformylase [EC:3.5.1.10]-01 0 histone H1/5-30 0 DNA mismatch repair protein MSH6-08 0 small subunit ribosomal protein SAe-30 0 protein kinase; cGMP-dependent [EC:2.7.11.12]-30 0 small protein A-30 0 aldose 1-epimerase [EC:5.1.3.3]-01 0 small ubiquitin-related modifier-30 0 T-complex protein 1 subunit beta-30 0 heat shock protein 90kDa beta-08 0 fused [EC:2.7.11.1]-08 0 collagen; type I/II/III/V/XI; alpha-30 0 tyrosine-specific transport protein-08 0 sulfoquinovosyltransferase [EC:2.4.1.-]-08 0 biotin biosynthesis protein BioH-30 0 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) [EC:3.6.1.41]-30 0 nitrile hydratase [EC:4.2.1.84]-30 0 CRP/FNR family transcriptional regulator; anaerobic regulatory-08 0 putative hemin transport protein-08 0 T-complex protein 1 subunit zeta-30 0 preprotein translocase subunit SecG-01 0.01 tRNA 2-thiouridine synthesizing protein C-08 0 iron complex transport system permease protein-01 0 ATP synthase protein I-30 0 multicomponent K+:H+ antiporter subunit A-30 0 isoquinoline 1-oxidoreductase; alpha subunit [EC:1.3.99.16]-30 0 putative protein-disulfide isomerase-01 0 putative drug exporter of the RND superfamily-30 0 sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]-08 0 U4/U6.U5 tri-snRNP-associated protein 2-30 0 two-component system; OmpR family; sensor histidine kinase KdpD-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 691 of 848

GntR family transcriptional regulator; histidine utilization-30 0 glucoamylase [EC:3.2.1.3]-30 0 chorismate mutase [EC:5.4.99.5]-01 0.01 integrator complex subunit 11 [EC:3.1.27.-]-08 0 alpha-glucosidase [EC:3.2.1.20]-30 0 AP-4 complex subunit epsilon-1-08 0 formylmethanofuran dehydrogenase subunit A [EC:1.2.99.5]-08 0 type IV pilus assembly protein PilA-08 0 putative permease-01 0 two-component system; NtrC family; response regulator YfhA-30 0 prephenate dehydrogenaseFor [EC:1.3.1.12]-01 Peer Review Only0.01 subtilisin [EC:3.4.21.62]-30 0 T-complex protein 1 subunit beta-08 0 translocation protein SEC63-30 0 agmatine deiminase [EC:3.5.3.12]-01 0 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate-01 0 beta-adrenergic-receptor kinase [EC:2.7.11.15]-30 0 carboxylesterase type B [EC:3.1.1.1]-30 0 uridine phosphorylase [EC:2.4.2.3]-01 0 homoserine kinase type II [EC:2.7.1.39]-30 0 small subunit ribosomal protein S5e-30 0 thiopurine S-methyltransferase [EC:2.1.1.67]-30 0 Fur family transcriptional regulator; zinc uptake regulator-01 0 xylulokinase [EC:2.7.1.17]-01 0 AP-3 complex subunit beta-30 0 nitrogen regulatory protein P-II 2-30 0 polyphosphate kinase [EC:2.7.4.1]-01 0.01 penicillin-binding protein 1C [EC:2.4.1.-]-30 0 penicillin-insensitive murein endopeptidase [EC:3.4.24.-]-30 0 haloalkane dehalogenase [EC:3.8.1.5]-01 0 microsomal epoxide hydrolase [EC:3.3.2.9]-30 0 DeoR family transcriptional regulator; glycerol-3-phosphate regulon-01 0 RuvB-like protein 2 [EC:3.6.1.-]-08 0 D-lactate dehydrogenase (cytochrome) [EC:1.1.2.4]-30 0 adenine deaminase [EC:3.5.4.2]-01 0 sigma-E factor negative regulatory protein RseB-30 0 transcription initiation factor TFIIB-30 0 DnaJ homolog subfamily A member 2-30 0 small subunit ribosomal protein S2e-30 0 disulfide bond formation protein DsbB-30 0 20S proteasome subunit alpha 1 [EC:3.4.25.1]-08 0 molybdenum cofactor biosynthesis protein E-01 0.01 integration host factor subunit alpha-30 0 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation-08 0 myosin I-08 0 anaphase-promoting complex subunit 1-30 0 dCMP deaminase [EC:3.5.4.12]-01 0

Wiley-Blackwell and Society for Applied Microbiology Page 692 of 848

hydroxypyruvate isomerase [EC:5.3.1.22]-30 0 phosphoheptose isomerase [EC:5.-.-.-]-01 0.01 2-oxoglutarate ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3]-01 0 geranylgeranyl diphosphate synthase; type II [EC:2.5.1.1 2.5.1.10-30 0 proteasome component ECM29-08 0 DNA repair protein RadA-08 0 MFS transporter; FHS family; L-fucose permease-01 0 D-ribose pyranase [EC:5.-.-.-]-08 0 survival motor neuron protein-30 0 pyruvate dehydrogenase kinase [EC:2.7.11.2]-30 0 cholesterol oxidase For[EC:1.1.3.6]-30 Peer Review Only 0 pre-mRNA-processing factor 17-08 0 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [EC:1.1.1.-]-30 0 acetyl-/propionyl-CoA carboxylase; biotin carboxylase; biotin-30 0 polar amino acid transport system substrate-binding protein-01 0.01 diphthine synthase [EC:2.1.1.98]-08 0 tripeptidyl-peptidase I [EC:3.4.14.9]-30 0 carboxynorspermidine decarboxylase [EC:4.1.1.-]-08 0 U4/U6 small nuclear ribonucleoprotein PRP4-30 0 formamidase [EC:3.5.1.49]-30 0 2-dehydro-3-deoxygalactonokinase [EC:2.7.1.58]-30 0 hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]-30 0 photosystem II PsbE protein-08 0 endothelin-converting enzyme [EC:3.4.24.71]-08 0 1;4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.-]-30 0 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation-30 0 uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase /-30 0 syntaxin 6-08 0 anthranilate synthase [EC:4.1.3.27]-08 0 exonuclease SbcD-30 0 calnexin-08 0 two-component system; OmpR family; sensor histidine kinase CpxA-08 0 calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17]-30 0 aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit C-30 0 minichromosome maintenance protein 3-08 0 WNK lysine deficient protein kinase [EC:2.7.11.1]-08 0 chemotaxis protein methyltransferase CheR [EC:2.1.1.80]-30 0 translation initiation factor eIF-3 subunit 5-30 0 ribonuclease T [EC:3.1.13.-]-30 0 thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]-01 0.01 C4-dicarboxylate transporter; DctM subunit-01 0 gluconate 5-dehydrogenase [EC:1.1.1.69]-30 0 large subunit ribosomal protein L9e-08 0 bifunctional enzyme CysN/CysC [EC:2.7.7.4 2.7.1.25]-30 0 pyrimidine operon attenuation protein / uracil-01 0 PhoH-like ATPase-01 0 protein mago nashi-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 693 of 848

translation initiation factor eIF-3 subunit 2-08 0 excinuclease Cho [EC:3.1.25.-]-08 0 small multidrug resistance protein; SMR family-30 0 arsenite transporter; ACR3 family-30 0 kinesin family member 18/19-08 0 bifunctional aspartokinase/homoserine dehydrogenase 2 [EC:2.7.2.4-30 0 splicing factor U2AF 35 kDa subunit-08 0 ubiquitin-like 1-activating enzyme E1 B [EC:6.3.2.19]-30 0 UDP-N-acetylglucosamine-lysosomal-enzyme [EC:2.7.8.17]-08 0 U5 snRNP protein; DIM1 family-08 0 choline-sulfatase [EC:3.1.6.6]-30For Peer Review Only 0 adenosylcobinamide-phosphate synthase CobD [EC:6.3.1.10]-01 0 phosphatidylinositol 3-kinase [EC:2.7.1.137]-30 0 pyruvate carboxylase subunit B [EC:6.4.1.1]-30 0 putative multiple sugar transport system ATP-binding protein-08 0 T-complex protein 1 subunit eta-30 0 myo-inositol-1-phosphate synthase [EC:5.5.1.4]-30 0 chromosome transmission fidelity protein 4-08 0 NADH dehydrogenase I subunit J [EC:1.6.5.3]-30 0 ATP-binding cassette; subfamily C (CFTR/MRP); member 2-08 0 periplasmic glucans biosynthesis protein-08 0 choloylglycine hydrolase [EC:3.5.1.24]-08 0 small ubiquitin-related modifier-08 0 DNA mismatch repair protein MSH2-30 0 thymidine phosphorylase [EC:2.4.2.4]-01 0 putative spermidine/putrescine transport system substrate-binding-01 0.01 MFS transporter; DHA2 family; methyl viologen resistance protein-08 0 UDP-N-acetylglucosamine 2-epimerase [EC:5.1.3.14]-01 0.01 X-Pro dipeptidyl-peptidase [EC:3.4.14.11]-08 0 ADP-ribose diphosphatase [EC:3.6.1.-]-01 0 N utilization substance protein B-01 0.01 alpha;alpha-trehalase [EC:3.2.1.28]-08 0 preprotein translocase subunit YajC-30 0 allophanate hydrolase [EC:3.5.1.54]-08 0 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]-01 0.01 DamX protein-08 0 26S proteasome regulatory subunit N5-30 0 fructokinase [EC:2.7.1.4]-01 0.01 beta-carotene ketolase (CrtW type)-08 0 photosystem II PsbA protein-01 0 flagellar assembly protein FliH-30 0 spore photoproduct lyase [EC:4.1.99.-]-08 0 inositol hexakisphosphate/diphosphoinositol-pentakisphosphate kinase-30 0 3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.-]-01 0 replication factor C small subunit-30 0 succinyl-CoA synthetase alpha subunit [EC:6.2.1.4 6.2.1.5]-30 0 methylglutaconyl-CoA hydratase [EC:4.2.1.18]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 694 of 848

DNA-directed RNA polymerase I subunit A2 [EC:2.7.7.6]-08 0 xanthine dehydrogenase accessory factor-01 0 aldehyde:ferredoxin oxidoreductase [EC:1.2.7.5]-08 0 ATP-dependent RNA helicase DDX18 [EC:3.6.1.-]-30 0 manganese/iron transport system ATP-binding protein-30 0 AP-2 complex subunit alpha-08 0 small subunit ribosomal protein S18e-08 0 pre-mRNA-splicing factor SYF1-08 0 small subunit ribosomal protein S19e-08 0 C4-dicarboxylate transporter; DcuC family-08 0 PhnP protein-30 For Peer Review Only 0 ATP-dependent RNA helicase DDX5/DBP2 [EC:3.6.1.-]-08 0 small subunit ribosomal protein S19-01 0.01 tRNA-dihydrouridine synthase B [EC:1.-.-.-]-30 0 ribosomal-protein-alanine N-acetyltransferase [EC:2.3.1.128]-01 0 V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14]-30 0 leader peptidase (prepilin peptidase) / N-methyltransferase-01 0.01 polyketide synthase PksJ-08 0 structure-specific recognition protein 1-30 0 small subunit ribosomal protein S27Ae-30 0 putative ABC transport system permease protein-01 0 ribonuclease T [EC:3.1.13.-]-01 0 phosphoribosylaminoimidazole carboxylase [EC:4.1.1.21]-30 0 urease gamma subunit [EC:3.5.1.5]-30 0 RuvB-like protein 1 (pontin 52)-30 0 hydroxyatrazine ethylaminohydrolase [EC:3.5.99.3]-30 0 hexaprenyl diphosphate synthase [EC:2.5.1.33]-30 0 phosphoethanolamine transferase-30 0 mercuric reductase [EC:1.16.1.1]-01 0 two-component system; LytT family; response regulator-30 0 UDP-galactopyranose mutase [EC:5.4.99.9]-30 0 monovalent cation:H+ antiporter; CPA1 family-30 0 mono-ADP-ribosyltransferase sirtuin 6 [EC:2.4.2.31]-08 0 20S proteasome subunit beta 5 [EC:3.4.25.1]-08 0 uncharacterized zinc-type alcohol dehydrogenase-like protein-30 0 metal ion transporter; MIT family-30 0 putative thiamine transport system permease protein-30 0 homoserine kinase [EC:2.7.1.39]-01 0 CCR4-NOT transcription complex subunit 9-30 0 26S proteasome regulatory subunit N7-08 0 manganese/zinc/iron transport system substrate-binding protein-30 0 dihydroaeruginoic acid synthetase-08 0 urease gamma subunit [EC:3.5.1.5]-08 0 cell division inhibitor SulA-08 0 sorbitol/mannitol transport system substrate-binding protein-30 0 pentafunctional AROM polypeptide [EC:4.2.3.4 4.2.1.10 1.1.1.25-30 0 nucleosome assembly protein 1-like 1-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 695 of 848

hemolysin III-01 0 N-acetylglucosamine kinase [EC:2.7.1.59]-08 0 casein kinase 2; alpha polypeptide [EC:2.7.11.1]-30 0 UV excision repair protein RAD23-30 0 acid phosphatase (class A) [EC:3.1.3.2]-08 0 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]-01 0.01 S-phase kinase-associated protein 1-08 0 large subunit ribosomal protein LP0-30 0 electron transport complex protein RnfE-30 0 phycocyanin beta chain-08 0 sialate O-acetylesteraseFor [EC:3.1.1.53]-01 Peer Review Only 0 leishmanolysin-like peptidase [EC:3.4.24.-]-30 0 fructose transport system substrate-binding protein-08 0 poly(3-hydroxybutyrate) depolymerase [EC:3.1.1.75]-08 0 large subunit ribosomal protein L7e-08 0 LysR family transcriptional regulator; cys regulon transcriptional-30 0 cytochrome o ubiquinol oxidase operon protein cyoD-08 0 MSHA biogenesis protein MshM-08 0 ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19]-08 0 formiminoglutamase [EC:3.5.3.8]-01 0 cell division cycle 2-like [EC:2.7.11.22]-30 0 transducin (beta)-like 1-08 0 chitinase [EC:3.2.1.14]-08 0 naphthoate synthase [EC:4.1.3.36]-01 0 putative acetyltransferase [EC:2.3.1.-]-01 0.01 stage V sporulation protein R-30 0 xanthine dehydrogenase YagS FAD-binding subunit [EC:1.17.1.4]-08 0 ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]-08 0 short-chain fatty acids transporter-30 0 large subunit ribosomal protein L40e-08 0 heat shock protein HtpX [EC:3.4.24.-]-30 0 Hit-like protein involved in cell-cycle regulation-30 0 U6 snRNA-associated Sm-like protein LSm6-08 0 LPPG:FO 2-phospho-L-lactate transferase [EC:2.7.8.-]-08 0 transcription elongation factor GreB-30 0 mitochondrial carrier protein; MC family-30 0 3-phytase [EC:3.1.3.8]-08 0 glyceraldehyde-3-phosphate dehydrogenase (NADP) [EC:1.2.1.9]-30 0 nitrogen regulatory protein P-II 1-01 0 LPPG:FO 2-phospho-L-lactate transferase [EC:2.7.8.-]-30 0 cyclin-dependent kinase 7 [EC:2.7.11.22]-30 0 putative signal transduction protein containing EAL and modified-08 0 tricorn protease [EC:3.4.21.-]-30 0 general secretion pathway protein G-30 0 small subunit ribosomal protein S16e-30 0 alpha-mannosidase [EC:3.2.1.24]-30 0 serine-threonine kinase receptor-associated protein-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 696 of 848

cytochrome P450; family 51 (sterol 14-demethylase) [EC:1.14.13.70]-08 0 Hit-like protein involved in cell-cycle regulation-01 0 ethanolaminephosphotransferase [EC:2.7.8.1]-30 0 serralysin [EC:3.4.24.40]-01 0 pre-mRNA-processing factor 17-30 0 guanine deaminase [EC:3.5.4.3]-30 0 thiamine transport system permease protein-30 0 type III restriction enzyme [EC:3.1.21.5]-30 0 flagellar protein FliO/FliZ-08 0 menaquinone-specific isochorismate synthase [EC:5.4.4.2]-30 0 elongator complex proteinFor 1-30 Peer Review Only 0 cell division cycle 2-like [EC:2.7.11.22]-08 0 U4/U6.U5 tri-snRNP-associated protein 1-30 0 geranylgeranyl reductase [EC:1.3.1.83]-30 0 large subunit ribosomal protein L6e-08 0 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4]-01 0 syntaxin 1B/2/3-08 0 histone acetyltransferase [EC:2.3.1.48]-08 0 NADH dehydrogenase [EC:1.6.5.3]-08 0 carnitine operon protein CaiE-30 0 SET domain-containing protein 6-08 0 phosphotransferase system; enzyme I; PtsI [EC:2.7.3.9]-30 0 cytosolic nonspecific dipeptidase-08 0 putrescine transport system ATP-binding protein-30 0 glucose-fructose oxidoreductase [EC:1.1.99.28]-30 0 sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]-01 0 ribose transport system substrate-binding protein-01 0 cytochrome b561-30 0 D-erythrose 4-phosphate dehydrogenase [EC:1.2.1.72]-30 0 PhnI protein-08 0 creatinine amidohydrolase [EC:3.5.2.10]-30 0 multidrug resistance protein A-30 0 NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]-01 0 NAD+ diphosphatase [EC:3.6.1.22]-01 0 UV DNA damage endonuclease [EC:3.-.-.-]-08 0 guanosine-5'-triphosphate;3'-diphosphate pyrophosphatase-30 0 condensin complex subunit 1-08 0 indole-3-glycerol phosphate synthase / phosphoribosylanthranilate-30 0 tricarballylate dehydrogenase-08 0 proline dehydrogenase [EC:1.5.99.8]-01 0 holo-[acyl-carrier protein] synthase [EC:2.7.8.7]-01 0.01 isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]-30 0 solute carrier family 8 (sodium/calcium exchanger)-30 0 replication factor A1-30 0 transcription initiation factor TFIID TATA-box-binding protein-30 0 pre-mRNA-processing factor 19 [EC:6.3.2.19]-08 0 peroxin-5-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 697 of 848

eukaryotic translation initiation factor 2-alpha kinase-30 0 pyrophosphate--fructose-6-phosphate 1-phosphotransferase-08 0 SEC-C motif domain protein-30 0 fructuronate reductase [EC:1.1.1.57]-30 0 glutamate/aspartate transport system ATP-binding protein-08 0 calcium-dependent protein kinase [EC:2.7.11.1]-08 0 D-citramalate synthase [EC:2.3.1.182]-08 0 structural maintenance of chromosome 1-08 0 peptidylprolyl isomerase domain and WD repeat-containing protein 1-08 0 large subunit ribosomal protein L11e-30 0 host factor-I protein-30For Peer Review Only 0 sulfite oxidase [EC:1.8.3.1]-08 0 esterase / lipase [EC:3.1.1.-]-30 0 V-type H+-transporting ATPase 16kDa proteolipid subunit-30 0 cyclin B-08 0 beta-glucuronidase [EC:3.2.1.31]-08 0 T-complex protein 1 subunit epsilon-30 0 ATP-dependent RNA helicase DDX18 [EC:3.6.1.-]-08 0 two-component system; LytT family; sensor histidine kinase AlgZ-08 0 queuosine biosynthesis protein QueE-08 0 flagellar M-ring protein FliF-01 0 charged multivesicular body protein 1-08 0 large subunit ribosomal protein L33-01 0 glucarate dehydratase [EC:4.2.1.40]-08 0 T-complex protein 1 subunit theta-30 0 RNA-binding motif protein; X-linked 2-30 0 lipopolysaccharide transport system permease protein-08 0 spermidine dehydrogenase [EC:1.5.99.6]-30 0 protein phosphatase 3; catalytic subunit [EC:3.1.3.16]-08 0 flagellar protein FlgJ-30 0 cytochrome o ubiquinol oxidase subunit I [EC:1.10.3.-]-01 0 pleiotropic regulator 1-08 0 putative toluene tolerance protein-01 0 spectrin beta-08 0 thiol peroxidase; atypical 2-Cys peroxiredoxin [EC:1.11.1.15]-08 0 glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]-30 0 DNA polymerase II large subunit [EC:2.7.7.7]-30 0 acetyl-CoA acyltransferase 1 [EC:2.3.1.16]-30 0 protein phosphatase 3; catalytic subunit [EC:3.1.3.16]-30 0 putative toluene tolerance protein-30 0 20S proteasome subunit alpha 3 [EC:3.4.25.1]-08 0 protein phosphatase 5 [EC:3.1.3.16]-30 0 glucose-1-phosphate cytidylyltransferase [EC:2.7.7.33]-01 0.01 translation initiation factor eIF-1A-08 0 methionine-gamma-lyase [EC:4.4.1.11]-01 0 cellular nucleic acid-binding protein-08 0 homospermidine synthase [EC:2.5.1.44]-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 698 of 848

serine protease SohB [EC:3.4.21.-]-01 0 cyanate lyase [EC:4.2.1.104]-30 0 splicing factor U2AF 65 kDa subunit-30 0 D-citramalate synthase [EC:2.3.1.182]-01 0 C4-dicarboxylate-binding protein DctP-01 0 UDP-GlcNAc3NAcA epimerase [EC:5.1.3.23]-08 0 large subunit ribosomal protein L36-01 0 sarcosine oxidase; subunit gamma [EC:1.5.3.1]-30 0 serine--glyoxylate transaminase [EC:2.6.1.45]-01 0 kelch-like protein 17 (actinfilin)-08 0 minichromosome maintenanceFor proteinPeer 9-08 Review Only 0 phosphonoacetate hydrolase [EC:3.11.1.2]-30 0 nitronate monooxygenase [EC:1.13.12.16]-01 0 large subunit ribosomal protein L12-08 0 cell division control protein 45-08 0 translation initiation factor eIF-5-08 0 pyrroloquinoline quinone biosynthesis protein E-08 0 dihydroorotate dehydrogenase [EC:1.3.5.2]-08 0 zinc transporter; ZIP family-30 0 small multidrug resistance protein; SMR family-01 0.01 RNA-directed DNA polymerase [EC:2.7.7.49]-30 0 4;5-dihydroxyphthalate decarboxylase [EC:4.1.1.55]-08 0 Rab family; other-08 0 succinyl-CoA synthetase alpha subunit [EC:6.2.1.4 6.2.1.5]-08 0 dipeptide transport system permease protein-01 0 superoxide dismutase; Fe-Mn family [EC:1.15.1.1]-01 0 propionyl-CoA carboxylase beta chain [EC:6.4.1.3]-01 0 recombination associated protein RdgC-30 0 protein phosphatase 2 (formerly 2A); regulatory subunit B''-30 0 rubredoxin-NAD+ reductase [EC:1.18.1.1]-30 0 ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]-30 0 ATP-binding cassette; subfamily C; bacterial-30 0 adenosine kinase [EC:2.7.1.20]-08 0 dynein heavy chain; axonemal-01 0 histone-arginine methyltransferase CARM1 [EC:2.1.1.125]-08 0 protease I [EC:3.2.-.-]-08 0 large subunit ribosomal protein L4e-30 0 periplasmic divalent cation tolerance protein-08 0 two-component system; OmpR family; response regulator RpaB-30 0 splicing factor 1-30 0 methylmalonyl-CoA mutase; N-terminal domain [EC:5.4.99.2]-30 0 LacI family transcriptional regulator-01 0 DNA polymerase alpha subunit B-30 0 general secretion pathway protein H-30 0 phosphoacetylglucosamine mutase [EC:5.4.2.3]-08 0 DNA primase large subunit [EC:2.7.7.-]-08 0 DNA mismatch repair protein MLH1-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 699 of 848

vacuolar protein-sorting-associated protein 4-30 0 chromosome transmission fidelity protein 18-30 0 Ca2+-transporting ATPase [EC:3.6.3.8]-30 0 ATP-dependent RNA helicase DDX23/PRP28 [EC:3.6.1.-]-08 0 phosphoribosylamine--glycine ligase / phosphoribosylglycinamide-30 0 monothiol glutaredoxin-30 0 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]-08 0 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5]-01 0 triple functional domain protein [EC:2.7.11.-]-08 0 uncharacterized oxidoreductase [EC:1.1.1.-]-08 0 cb-type cytochromeFor c oxidase subunit Peer III [EC:1.9.3.1]-08 Review Only 0 H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]-08 0 HemY protein-01 0 uridine phosphorylase [EC:2.4.2.3]-30 0 benzoate membrane transport protein-30 0 complement component 1; r subcomponent [EC:3.4.21.41]-30 0 large subunit ribosomal protein L7Ae-30 0 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)-08 0 zinc/manganese transport system permease protein-30 0 recombination associated protein RdgC-08 0 RAD51-like protein 1-08 0 ferrous iron transport protein A-08 0 K+-transporting ATPase ATPase B chain [EC:3.6.3.12]-08 0 ureidoglycolate hydrolase [EC:3.5.3.19]-30 0 CCR4-NOT transcription complex subunit 6 [EC:3.1.-.-]-08 0 long-chain fatty acid transport protein-30 0 cell division cycle 20; cofactor of APC complex-30 0 3-hydroxyacyl-CoA dehydrogenase /-08 0 GTP-binding nuclear protein Ran-30 0 DNA polymerase (family X)-30 0 beta-aspartyl-dipeptidase (metallo-type) [EC:3.4.19.-]-30 0 DNA-directed RNA Polymerase III subunit C5 [EC:2.7.7.6]-30 0 kinesin family member 4/7/21/27-08 0 nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-]-30 0 thrombospondin-related anonymous protein-30 0 PKHD-type hydroxylase [EC:1.14.11.-]-30 0 pyrroloquinoline quinone biosynthesis protein B-01 0 two-component system; NtrC family; C4-dicarboxylate transport-01 0 protein Mpv17-30 0 tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]-01 0 AP-3 complex subunit mu-08 0 catechol 1;2-dioxygenase [EC:1.13.11.1]-08 0 phosphoenolpyruvate phosphomutase [EC:5.4.2.9]-01 0 rRNA (guanine-N1-)-methyltransferase [EC:2.1.1.51]-08 0 phycobilisome core component-08 0 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase-30 0 polar amino acid transport system ATP-binding protein [EC:3.6.3.21]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 700 of 848

glucosamine-6-phosphate deaminase [EC:3.5.99.6]-30 0 thiol peroxidase; atypical 2-Cys peroxiredoxin [EC:1.11.1.15]-30 0 DNA repair protein RAD50 [EC:3.6.-.-]-08 0 purine-nucleoside phosphorylase [EC:2.4.2.1]-01 0 stromal membrane-associated protein-30 0 adenylylsulfate kinase [EC:2.7.1.25]-01 0.01 maltose O-acetyltransferase [EC:2.3.1.79]-08 0 adenosine kinase [EC:2.7.1.20]-30 0 ornithine cyclodeaminase [EC:4.3.1.12]-01 0 cytochrome b561-01 0 L-fucose isomerase [EC:5.3.1.25]-08For Peer Review Only 0 kinesin family member C1-30 0 sulfate-transporting ATPase [EC:3.6.3.25]-08 0 aspartoacylase [EC:3.5.1.15]-30 0 MFS transporter; DHA2 family; methyl viologen resistance protein-30 0 ribonuclease HIII [EC:3.1.26.4]-08 0 fanconi anemia group M protein [EC:3.6.1.-]-30 0 splicing factor 3B subunit 2-30 0 DNA-directed RNA Polymerase II subunit L-08 0 6-phosphogluconolactonase [EC:3.1.1.31]-01 0 mannosyl-oligosaccharide alpha-1;2-mannosidase [EC:3.2.1.113]-30 0 arginine N-succinyltransferase [EC:2.3.1.109]-30 0 triple functional domain protein [EC:2.7.11.-]-30 0 DNA polymerase II large subunit [EC:2.7.7.7]-01 0 lactoylglutathione lyase [EC:4.4.1.5]-01 0.01 2-haloacid dehalogenase [EC:3.8.1.2]-01 0.01 disulfide bond formation protein DsbB-01 0.01 L-fuculose-phosphate aldolase [EC:4.1.2.17]-01 0 polyketide synthase 12-30 0 ubiquilin-30 0 osmoprotectant transport system permease protein-30 0 large subunit ribosomal protein L8e-30 0 protein kinase; cGMP-dependent [EC:2.7.11.12]-08 0 succinylarginine dihydrolase [EC:3.5.3.23]-01 0 small subunit ribosomal protein S6e-30 0 O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase-08 0 paired amphipathic helix protein Sin3a-08 0 E3 ubiquitin-protein ligase BRE1 [EC:6.3.2.19]-30 0 D-aminopeptidase [EC:3.4.11.19]-30 0 pyrroloquinoline-quinone synthase [EC:1.3.3.11]-30 0 methylmalonyl-CoA mutase; C-terminal domain [EC:5.4.99.2]-08 0 bilin biosynthesis protein-30 0 5-methylthioribose kinase [EC:2.7.1.100]-30 0 periplasmic glucans biosynthesis protein-30 0 phosphohistidine phosphatase [EC:3.1.3.-]-30 0 U4/U6 small nuclear ribonucleoprotein PRP31-30 0 phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 701 of 848

heat-inducible transcriptional repressor-30 0 THO complex subunit 2-08 0 DnaA-homolog protein-30 0 UDP-glucuronate 5'-epimerase [EC:5.1.3.12]-08 0 transcription initiation factor TFIIH subunit H4-08 0 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17]-08 0 aarF domain-containing kinase-08 0 ribosomal RNA large subunit methyltransferase F [EC:2.1.1.48]-01 0 sister chromatid cohesion protein PDS5-08 0 RNA-binding protein FUS-08 0 AP-1 complex subunitFor beta-1-08 Peer Review Only 0 sulfoacetaldehyde acetyltransferase [EC:2.3.3.15]-30 0 stringent starvation protein B-01 0 phosphatidylinositol glycan; class A [EC:2.4.1.198]-08 0 general secretion pathway protein M-30 0 26S proteasome regulatory subunit N8-08 0 indolepyruvate ferredoxin oxidoreductase; beta subunit [EC:1.2.7.8]-08 0 dipeptide transport system ATP-binding protein-01 0 glucosylceramidase [EC:3.2.1.45]-30 0 S-formylglutathione hydrolase [EC:3.1.2.12]-01 0 nestin-30 0 splicing factor 3B subunit 4-30 0 alkane 1-monooxygenase [EC:1.14.15.3]-01 0 aspartyl protease family protein-08 0 MFS transporter; BCD family; chlorophyll transporter-30 0 small subunit ribosomal protein S3e-30 0 nonsense-mediated mRNA decay protein 3-30 0 26S proteasome regulatory subunit T4-08 0 putative hemolysin-30 0 cytochrome P450; family 4; subfamily F (leukotriene-B4-08 0 alcohol dehydrogenase (acceptor) [EC:1.1.99.8]-30 0 2-pyrone-4;6-dicarboxylate lactonase [EC:3.1.1.57]-08 0 prolyl 4-hydroxylase; beta polypeptide [EC:5.3.4.1]-08 0 large subunit ribosomal protein L7Ae-08 0 exosome complex component RRP4-08 0 histone-lysine N-methyltransferase SETD1 [EC:2.1.1.43]-08 0 vitamin B12 transport system substrate-binding protein-08 0 arsenate reductase [EC:1.20.4.1]-01 0 ADP-ribosylation factor-like 2-30 0 pyrophosphate--fructose-6-phosphate 1-phosphotransferase-30 0 molybdate transport system ATP-binding protein-30 0 two-component system; NtrC family; response regulator PilR-30 0 nucleophosmin 1-08 0 glycoprotein 3-alpha-L-fucosyltransferase [EC:2.4.1.214]-30 0 charged multivesicular body protein 3-08 0 chromosome transmission fidelity protein 1 [EC:3.6.1.-]-08 0 lignostilbene-alpha;beta-dioxygenase [EC:1.13.11.43]-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 702 of 848

flagellar biosynthetic protein FliR-30 0 fatty acid synthase; bacteria type [EC:2.3.1.-]-30 0 putative mRNA 3-end processing factor-30 0 glucose 1-dehydrogenase [EC:1.1.1.47]-08 0 O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase-30 0 histone H2A-30 0 dihydroorotate dehydrogenase [EC:1.3.5.2]-30 0 DNA glycosylase [EC:3.2.2.-]-30 0 large subunit ribosomal protein L19e-08 0 Lrp/AsnC family transcriptional regulator-30 0 ATP-dependent RNAFor helicase DDX5/DBP2 Peer [EC:3.6.1.-]-30 Review Only 0 myeloid/lymphoid or mixed-lineage leukemia protein 2-30 0 dihydroxyacetone kinase; N-terminal domain [EC:2.7.1.-]-08 0 alpha-1;3-glucosyltransferase [EC:2.4.1.-]-30 0 glutamyl-tRNA(Gln) amidotransferase subunit D [EC:6.3.5.7]-08 0 response regulator NasT-08 0 NADH dehydrogenase I subunit K [EC:1.6.5.3]-30 0 DNA-directed RNA polymerase II subunit C-30 0 carnitine operon protein CaiE-08 0 lysosomal alpha-mannosidase [EC:3.2.1.24]-30 0 galactosylceramidase [EC:3.2.1.46]-08 0 diamine N-acetyltransferase [EC:2.3.1.57]-08 0 CCR4-NOT transcription complex subunit 3-30 0 origin recognition complex subunit 1-08 0 cysteine synthase B [EC:2.5.1.47]-30 0 methylated-DNA-protein-cysteine methyltransferase related protein-30 0 small subunit ribosomal protein S3Ae-30 0 alpha-glucoside transport system ATP-binding protein-08 0 two-component system; OmpR family; response regulator RstA-30 0 serine/threonine protein phosphatase 1 [EC:3.1.3.16]-30 0 ATP-dependent RNA helicase RhlB [EC:3.6.1.-]-01 0 putative DNA methylase-08 0 mitochondrial import receptor subunit TOM40-08 0 LysR family transcriptional regulator; regulator for metE and metH-01 0 1;4-alpha-glucan branching enzyme [EC:2.4.1.18]-01 0 nickel/cobalt exporter-08 0 cobalamin biosynthesis protein CobW-01 0 cysteine desulfuration protein SufE-01 0 cytochrome o ubiquinol oxidase subunit I [EC:1.10.3.-]-30 0 dynein intermediate chain; cytosolic-30 0 allophycocyanin beta subunit-08 0 lipoprotein-34-30 0 phosphonate transport system permease protein-01 0 pre-mRNA-splicing factor 38B-30 0 methylisocitrate lyase [EC:4.1.3.30]-01 0.01 cell division cycle protein 37-08 0 uncharacterized protein involved in response to NO-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 703 of 848

large subunit ribosomal protein L17e-08 0 cell division cycle 20-like protein 1; cofactor of APC complex-30 0 glycerol uptake facilitator protein-08 0 N-acylmannosamine kinase [EC:2.7.1.60]-08 0 Lrp/AsnC family transcriptional regulator; leucine-responsive-30 0 type IV secretion system protein VirB4-30 0 20S proteasome subunit alpha 5 [EC:3.4.25.1]-08 0 acetyl-CoA acyltransferase 1 [EC:2.3.1.16]-08 0 flavodoxin I-30 0 dynein light intermediate chain; axonemal-08 0 V-type H+-transportingFor ATPase subunitPeer D [EC:3.6.3.14]-30 Review Only 0 putative pyruvate-flavodoxin oxidoreductase [EC:1.2.7.-]-08 0 lysosomal alpha-mannosidase [EC:3.2.1.24]-08 0 lysine 2;3-aminomutase [EC:5.4.3.2]-30 0 ArsR family transcriptional regulator-30 0 fructose-2;6-bisphosphatase [EC:3.1.3.46]-30 0 V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14]-30 0 tRNA pseudouridine synthase D [EC:5.4.99.12]-01 0 LuxR family transcriptional regulator; maltose regulon positive-30 0 mRNA-decapping enzyme subunit 2 [EC:3.-.-.-]-30 0 ribose transport system ATP-binding protein [EC:3.6.3.17]-30 0 inner centromere protein-30 0 cyclin-dependent kinase 7 [EC:2.7.11.22]-08 0 U2-associated protein SR140-08 0 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43-30 0 two-component system; OmpR family; sensor histidine kinase BaeS-30 0 MSHA biogenesis protein MshG-30 0 dihydroxyacetone kinase [EC:2.7.1.29]-30 0 LuxR family transcriptional regulator; maltose regulon positive-08 0 RNA-binding protein 39-30 0 octopine/nopaline transport system permease protein-01 0 psp operon transcriptional activator-08 0 sigma-E factor negative regulatory protein RseB-08 0 polar amino acid transport system permease protein-01 0 C4-dicarboxylate-binding protein DctP-30 0 glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]-01 0 cathepsin A [EC:3.4.16.5]-30 0 nitric-oxide synthase; invertebrate [EC:1.14.13.39]-08 0 H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]-30 0 protein phosphatase 2 (formerly 2A); catalytic subunit [EC:3.1.3.16]-08 0 ESCRT-I complex subunit TSG101-30 0 monothiol glutaredoxin-01 0.01 sulfatase modifying factor 1-08 0 sulfite reductase (ferredoxin) [EC:1.8.7.1]-30 0 DNA mismatch repair protein MSH4-30 0 two-component system; OmpR family; sensor histidine kinase QseC-08 0 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 704 of 848

sphingolipid delta-4 desaturase [EC:1.14.-.-]-08 0 large subunit ribosomal protein L30e-08 0 Ca2+ transporting ATPase; plasma membrane [EC:3.6.3.8]-30 0 phycocyanin alpha chain-08 0 phosphocarrier protein-08 0.01 AP-3 complex subunit mu-30 0 aerotaxis receptor-08 0 aldehyde dehydrogenase-08 0 alpha-glucoside transport system permease protein-08 0 conjugal transfer pilus assembly protein TraB-30 0 alkanesulfonate monooxygenaseFor Peer [EC:1.14.14.5]-01 Review Only 0 exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]-08 0 regulator of ribonuclease activity A-01 0 FK506-binding protein 4/5 [EC:5.2.1.8]-30 0 protein disulfide isomerase family A; member 6 [EC:5.3.4.1]-08 0 D-serine dehydratase [EC:4.3.1.18]-08 0 ApaG protein-30 0 large subunit ribosomal protein L24-01 0 Trp repressor binding protein-30 0 methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]-01 0.01 small subunit ribosomal protein S4e-30 0 flagellar hook-length control protein FliK-08 0 splicing factor 3A subunit 2-30 0 Bax protein-30 0 alpha-N-acetylglucosaminidase [EC:3.2.1.50]-08 0 phospholipase C [EC:3.1.4.3]-30 0 ER lumen protein retaining receptor-30 0 splicing factor U2AF 35 kDa subunit-30 0 photosystem I subunit IV-08 0 DNA-directed RNA polymerase subunit B' [EC:2.7.7.6]-08 0 formin 2-30 0 phosphatidylinositol-4;5-bisphosphate 3-kinase [EC:2.7.1.153]-08 0 fructose transport system substrate-binding protein-30 0 ubiquitin-protein ligase E3 C [EC:6.3.2.19]-08 0 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]-30 0 peroxin-6-30 0 ribonuclease P protein component [EC:3.1.26.5]-01 0.01 hydrogenase maturation protein HypF-08 0 circumsporozoite protein-08 0 carboxylesterase [EC:3.1.1.1]-08 0 exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]-01 0 cryptochrome-08 0 lipoprotein NlpD-01 0 TNF receptor-associated protein 1-08 0 ribosomal RNA small subunit methyltransferase D [EC:2.1.1.52]-30 0 translation initiation factor eIF-4A 3 [EC:3.6.1.-]-08 0 iron-sulfur cluster assembly protein-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 705 of 848

sorbitol/mannitol transport system substrate-binding protein-01 0 GDP-mannose 6-dehydrogenase [EC:1.1.1.132]-08 0 MSHA biogenesis protein MshK-08 0 sulfopyruvate decarboxylase subunit beta [EC:4.1.1.79]-30 0 troponin I; slow skeletal muscle-30 0 small subunit ribosomal protein S27e-08 0 erythrocyte membrane protein 1-08 0 citronellol/citronellal dehydrogenase-30 0 DNA polymerase kappa subunit [EC:2.7.7.7]-30 0 lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]-30 0 CDC-like kinase [EC:2.7.12.1]-08For Peer Review Only 0 cohesin loading factor subunit SCC2-08 0 2-dehydro-3-deoxyphosphogluconate aldolase /-01 0 phosphoribosylaminoimidazole carboxylase [EC:4.1.1.21]-08 0 D-xylose transport system substrate-binding protein-30 0 flagellar protein FlaG-08 0 bifunctional enzyme CysN/CysC [EC:2.7.7.4 2.7.1.25]-01 0 pre-mRNA-processing factor 6-08 0 general secretion pathway protein J-30 0 glucosylglycerol-phosphate synthase [EC:2.4.1.213]-30 0 A1 cistron-splicing factor AAR2-30 0 2-aminoadipate transaminase [EC:2.6.1.39]-08 0 gluconokinase [EC:2.7.1.12]-30 0 2-oxo-hept-3-ene-1;7-dioate hydratase [EC:4.2.1.-]-30 0 transcription initiation factor TFIID subunit D1-08 0 26S proteasome regulatory subunit N11-30 0 20S proteasome subunit beta 5 [EC:3.4.25.1]-30 0 large subunit ribosomal protein L8e-08 0 lipoate-protein ligase A [EC:2.7.7.63]-30 0 response regulator NasT-01 0 octopine/nopaline transport system permease protein-30 0 transcription initiation factor TFIID subunit D2-08 0 farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]-30 0 alpha-1;3-mannosyltransferase [EC:2.4.1.130]-08 0 DNA excision repair protein ERCC-4 [EC:3.1.-.-]-30 0 RuvB-like protein 1 (pontin 52)-08 0 DamX protein-30 0 26S proteasome regulatory subunit T3-30 0 electron transport complex protein RnfD-30 0 phosphatidylglycerophosphatase A [EC:3.1.3.27]-01 0.01 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase /-30 0 glycoside/pentoside/hexuronide:cation symporter; GPH family-30 0 Ca2+ transporting ATPase; sarcoplasmic/endoplasmic reticulum-30 0 biopolymer transport protein TolR-01 0 archaea-specific RecJ-like exonuclease-08 0 pre-mRNA-splicing factor SYF2-08 0 manganese/zinc/iron transport system ATP- binding protein-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 706 of 848

WD40 repeat-containing protein SMU1-08 0 UDP-D-GlcNAcA oxidase [EC:1.1.1.-]-01 0 transcription initiation factor TFIIH subunit H1-30 0 NAD-dependent histone deacetylase SIR2 [EC:3.5.1.-]-08 0 COP9 signalosome complex subunit 2-30 0 heterogeneous nuclear ribonucleoprotein F/H-30 0 THO complex subunit 2-30 0 translation initiation factor eIF-5A-30 0 alpha-1;2-mannosyltransferase [EC:2.4.1.-]-08 0 26S proteasome regulatory subunit N10-08 0 Ras-related protein ForRab-7A-30 Peer Review Only 0 pre-mRNA-processing factor SLU7-08 0 polo-like kinase 1 [EC:2.7.11.21]-08 0 dihydroxyacetone kinase; C-terminal domain [EC:2.7.1.-]-08 0 O-succinylbenzoic acid--CoA ligase [EC:6.2.1.26]-01 0 tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]-01 0 nitric-oxide reductase; cytochrome b-containing subunit I-30 0 serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1-30 0 large subunit ribosomal protein L10Ae-08 0 small subunit ribosomal protein S18-30 0 condensin-2 complex subunit D3-30 0 phosphoenolpyruvate phosphomutase [EC:5.4.2.9]-30 0 small subunit ribosomal protein S20-30 0 myosin heavy chain-08 0 dimethylaniline monooxygenase (N-oxide forming) [EC:1.14.13.8]-30 0 K+-transporting ATPase ATPase B chain [EC:3.6.3.12]-30 0 serine/threonine kinase 23 [EC:2.7.11.1]-08 0 protein arginine N-methyltransferase 1 [EC:2.1.1.-]-08 0 membrane-bound lytic murein transglycosylase B [EC:3.2.1.-]-01 0 competence/damage-inducible protein CinA-01 0.01 Cdc2-related kinase; arginine/serine-rich [EC:2.7.11.22]-08 0 flagellar P-ring protein precursor FlgI-01 0 polypeptide N-acetylglucosaminyltransferase [EC:2.4.1.-]-08 0 cell division protein FtsB-30 0 large subunit ribosomal protein L19e-30 0 type IV secretion system protein VirD4-30 0 cobalamin biosynthetic protein CobC-30 0 type IV pilus assembly protein PilZ-08 0 cell volume regulation protein A-08 0 large subunit ribosomal protein L23-01 0.01 GAF domain-containing protein-30 0 ATP-binding cassette; subfamily A (ABC1); member 3-30 0 large subunit ribosomal protein L10e-30 0 adenylyltransferase ThiF [EC:2.7.7.-]-30 0 sulfoquinovosyltransferase [EC:2.4.1.-]-30 0 putative tungstate transport system substrate-binding protein-30 0 small subunit ribosomal protein S24e-30 0

Wiley-Blackwell and Society for Applied Microbiology Page 707 of 848

LysR family transcriptional regulator; cys regulon transcriptional-01 0 formate dehydrogenase; gamma subunit [EC:1.2.1.2]-30 0 succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]-30 0 DNA mismatch repair protein MSH5-30 0 L-fucose mutarotase [EC:5.1.3.-]-01 0 serine protease Do [EC:3.4.21.107]-30 0 haloacetate dehalogenase [EC:3.8.1.3]-08 0 arylsulfatase I/J [EC:3.1.6.-]-08 0 molybdopterin-guanine dinucleotide biosynthesis protein B-30 0 UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-]-08 0 proliferating cell nuclearFor antigen-01 Peer Review Only 0 glutamate:Na+ symporter; ESS family-08 0 putative family 31 glucosidase-30 0 N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26]-30 0 ELAV like protein 2/3/4-30 0 huntingtin-30 0 lysine biosynthesis protein LysX-08 0 aminobutyraldehyde dehydrogenase [EC:1.2.1.19]-08 0 translation initiation factor eIF-4A-30 0 E3 ubiquitin-protein ligase HERC1 [EC:6.3.2.19]-08 0 UDP-sugar pyrophosphorylase [EC:2.7.7.64]-08 0 protein Mpv17-08 0 bloom syndrome protein [EC:3.6.1.-]-30 0 WD repeat and SOF domain-containing protein 1-30 0 conjugal transfer pilus assembly protein TraD-30 0 large subunit ribosomal protein L18e-30 0 flagellar assembly protein FliH-08 0 RIO kinase 1 [EC:2.7.11.1]-01 0 thiamine biosynthesis ThiH-08 0 diphthine synthase [EC:2.1.1.98]-30 0 glycerate kinase [EC:2.7.1.31]-30 0 spectrin beta-30 0 ubiquilin-08 0 cytochrome c heme-lyase [EC:4.4.1.17]-30 0 charged multivesicular body protein 2A-30 0 ubiquitin-conjugating enzyme E2 J2 [EC:6.3.2.19]-08 0 putative two-component system response regulator-08 0 nucleobase:cation symporter-1; NCS1 family-30 0 cell division control protein 45-30 0 LysR family transcriptional regulator; transcriptional activator of-30 0 putrescine transport system substrate-binding protein-30 0 ferredoxin--NAD+ reductase [EC:1.18.1.3]-30 0 polysaccharide transporter; PST family-08 0 peptidyl-prolyl isomerase D (cyclophilin D) [EC:5.2.1.8]-08 0 anaphase-promoting complex subunit 2-08 0 macrolide transport system ATP-binding/permease protein [EC:3.6.3.-]-08 0

Wiley-Blackwell and Society for Applied Microbiology Page 708 of 848

Contributions of KEGG ortholog groups to variance between the North and South zones. Average abundance North (standardised and log transformed) Contribution to variance (%) 0.24 0.26 0.57 0.24 0.24 0.15 0.19 0.14 0.24 0.12 0.04 0.12 0.19 0.12 0.08 0.12 For Peer Review0.17 Only 0.12 0.05 0.11 0.05 0.11 0.19 0.11 0.1 0.11 0.06 0.11 0.1 0.11 0.08 0.11 0.22 0.11 0.14 0.11 0.1 0.1 0.08 0.1 0.06 0.09 0.13 0.09 0.07 0.09 0.06 0.09 0.07 0.09 0.08 0.09 0.03 0.09 0.11 0.09 0.21 0.09 0.07 0.09 0.09 0.08 0.1 0.08 0.02 0.08 0.08 0.08 0.14 0.08 0.08 0.08 0.12 0.08 0.03 0.08 0.11 0.08 0.11 0.08 0.11 0.08 0.06 0.08 0.16 0.08 0.13 0.08 0.04 0.07

Wiley-Blackwell and Society for Applied Microbiology Page 709 of 848

0.08 0.07 0.12 0.07 0.06 0.07 0.23 0.07 0.04 0.07 0.06 0.07 0.17 0.07 0.1 0.07 0.05 0.07 0.05 0.07 For Peer Review0.08 Only 0.07 0.07 0.07 0.01 0.07 0.01 0.07 0.02 0.07 0.04 0.07 0.02 0.07 0.07 0.07 0.1 0.07 0.06 0.07 0.03 0.07 0.15 0.07 0.07 0.07 0.15 0.07 0.13 0.07 0.11 0.07 0.02 0.07 0.03 0.07 0.06 0.07 0.02 0.07 0.13 0.06 0.11 0.06 0.13 0.06 0.05 0.06 0.03 0.06 0.09 0.06 0.03 0.06 0.03 0.06 0.06 0.06 0.02 0.06 0.06 0.06 0.05 0.06 0.03 0.06 0.09 0.06 0.09 0.06 0.15 0.06 0.06 0.06

Wiley-Blackwell and Society for Applied Microbiology Page 710 of 848

0.02 0.06 0.13 0.06 0.03 0.06 0.06 0.06 0.02 0.06 0.05 0.06 0.13 0.06 0.12 0.06 0.1 0.06 0.05 0.06 For Peer Review0.07 Only 0.06 0.04 0.06 0.05 0.06 0.08 0.06 0.06 0.06 0.08 0.06 0.1 0.06 0.16 0.06 0.03 0.06 0.05 0.06 0.13 0.06 0.01 0.06 0.04 0.06 0.08 0.06 0.06 0.06 0.03 0.06 0.03 0.06 0.09 0.06 0.01 0.06 0.04 0.06 0.1 0.06 0.13 0.06 0.12 0.06 0.06 0.06 0.04 0.06 0.02 0.06 0.03 0.06 0.12 0.06 0.09 0.05 0.08 0.05 0.08 0.05 0.12 0.05 0.06 0.05 0.03 0.05 0.06 0.05 0.03 0.05 0.24 0.05

Wiley-Blackwell and Society for Applied Microbiology Page 711 of 848

0.02 0.05 0.04 0.05 0.03 0.05 0.02 0.05 0.15 0.05 0.02 0.05 0.01 0.05 0.09 0.05 0.05 0.05 0.01 0.05 For Peer Review0.05 Only 0.05 0.16 0.05 0.13 0.05 0.01 0.05 0.05 0.05 0.05 0.05 0.13 0.05 0.05 0.05 0.04 0.05 0.04 0.05 0.1 0.05 0.08 0.05 0.04 0.05 0.06 0.05 0.13 0.05 0.04 0.05 0.09 0.05 0.04 0.05 0.02 0.05 0.05 0.05 0.1 0.05 0.01 0.05 0.04 0.05 0.04 0.05 0.06 0.05 0.11 0.05 0.03 0.05 0.04 0.05 0.07 0.05 0.06 0.05 0.04 0.05 0.07 0.05 0.14 0.05 0.04 0.05 0.08 0.05 0.04 0.05 0.06 0.05

Wiley-Blackwell and Society for Applied Microbiology Page 712 of 848

0.03 0.05 0 0.05 0.07 0.05 0.04 0.05 0.03 0.05 0.07 0.05 0.02 0.05 0.11 0.05 0.14 0.05 0.07 0.05 For Peer Review0.1 Only 0.05 0.07 0.05 0.04 0.05 0.06 0.05 0.03 0.05 0.03 0.05 0.04 0.05 0.02 0.05 0.11 0.05 0.07 0.05 0.04 0.05 0.04 0.05 0.13 0.05 0.04 0.05 0.04 0.05 0.12 0.05 0.01 0.05 0.05 0.05 0.05 0.05 0.03 0.05 0.1 0.05 0.03 0.05 0.13 0.05 0.01 0.05 0.05 0.05 0.02 0.05 0.02 0.05 0.04 0.05 0.07 0.05 0.02 0.05 0.08 0.05 0.03 0.05 0.01 0.05 0.08 0.05 0.05 0.05 0.08 0.05 0.07 0.05

Wiley-Blackwell and Society for Applied Microbiology Page 713 of 848

0.09 0.05 0.12 0.04 0.06 0.04 0.02 0.04 0.08 0.04 0.07 0.04 0.06 0.04 0.02 0.04 0.07 0.04 0.02 0.04 For Peer Review0.04 Only 0.04 0.08 0.04 0.04 0.04 0.03 0.04 0.03 0.04 0.04 0.04 0.04 0.04 0.08 0.04 0.11 0.04 0.05 0.04 0.05 0.04 0.03 0.04 0.04 0.04 0.01 0.04 0.06 0.04 0.02 0.04 0.04 0.04 0.12 0.04 0.04 0.04 0.01 0.04 0.02 0.04 0.04 0.04 0.06 0.04 0.05 0.04 0.03 0.04 0.05 0.04 0.04 0.04 0.03 0.04 0.06 0.04 0.09 0.04 0.08 0.04 0.04 0.04 0.03 0.04 0.07 0.04 0.01 0.04 0.02 0.04 0.05 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 714 of 848

0.03 0.04 0.01 0.04 0.03 0.04 0.04 0.04 0.08 0.04 0.03 0.04 0.09 0.04 0.02 0.04 0.04 0.04 0.05 0.04 For Peer Review0.03 Only 0.04 0.02 0.04 0.04 0.04 0.03 0.04 0.01 0.04 0.04 0.04 0.08 0.04 0.03 0.04 0.08 0.04 0.04 0.04 0.09 0.04 0.05 0.04 0.01 0.04 0.01 0.04 0.03 0.04 0.06 0.04 0.04 0.04 0.05 0.04 0.02 0.04 0.03 0.04 0.13 0.04 0.06 0.04 0.04 0.04 0 0.04 0.09 0.04 0.04 0.04 0.04 0.04 0.03 0.04 0.02 0.04 0.06 0.04 0.02 0.04 0.02 0.04 0.07 0.04 0.09 0.04 0.08 0.04 0.06 0.04 0.02 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 715 of 848

0.02 0.04 0.03 0.04 0.08 0.04 0.06 0.04 0.01 0.04 0.03 0.04 0.03 0.04 0.03 0.04 0.06 0.04 0.06 0.04 For Peer Review0.03 Only 0.04 0.07 0.04 0.03 0.04 0.05 0.04 0 0.04 0.08 0.04 0.02 0.04 0.04 0.04 0.04 0.04 0.12 0.04 0.03 0.04 0.02 0.04 0.07 0.04 0.02 0.04 0.05 0.04 0.15 0.04 0.06 0.04 0.1 0.04 0.02 0.04 0.03 0.04 0.06 0.04 0.02 0.04 0.05 0.04 0.06 0.04 0.09 0.04 0.07 0.04 0.05 0.04 0.06 0.04 0.01 0.04 0.04 0.04 0.03 0.04 0.02 0.04 0.04 0.04 0.03 0.04 0.03 0.04 0.01 0.04 0.05 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 716 of 848

0.02 0.04 0.03 0.04 0.05 0.04 0.04 0.04 0.03 0.04 0.03 0.04 0.07 0.04 0.06 0.04 0.04 0.04 0.05 0.04 For Peer Review0.06 Only 0.04 0.01 0.04 0 0.04 0.03 0.04 0.03 0.04 0.06 0.04 0.03 0.04 0.11 0.04 0.03 0.04 0.06 0.04 0.03 0.04 0.03 0.04 0.05 0.04 0.08 0.04 0.02 0.04 0.06 0.04 0.03 0.04 0.06 0.04 0.08 0.04 0.07 0.04 0.04 0.04 0.03 0.04 0.1 0.04 0.13 0.04 0.03 0.04 0.03 0.04 0.09 0.04 0.04 0.04 0.02 0.04 0.04 0.04 0.07 0.04 0.04 0.04 0.01 0.04 0.05 0.04 0 0.04 0.06 0.04 0.05 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 717 of 848

0.02 0.04 0.06 0.04 0.01 0.04 0.07 0.04 0 0.04 0.05 0.04 0.03 0.04 0.01 0.04 0.02 0.04 0.01 0.04 For Peer Review0.03 Only 0.04 0.07 0.04 0.12 0.04 0.08 0.04 0.08 0.04 0.05 0.04 0.04 0.04 0.05 0.04 0.03 0.04 0.03 0.04 0.05 0.04 0.09 0.04 0.04 0.04 0.07 0.04 0.03 0.04 0.06 0.04 0.02 0.04 0.04 0.04 0.05 0.04 0.01 0.04 0.04 0.04 0.08 0.04 0.07 0.04 0.07 0.04 0.01 0.04 0.03 0.04 0.07 0.04 0.01 0.04 0.06 0.04 0.03 0.04 0.07 0.04 0.08 0.04 0.04 0.04 0.02 0.04 0.03 0.04 0.03 0.04 0.06 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 718 of 848

0.07 0.04 0.07 0.04 0.05 0.04 0 0.03 0.05 0.03 0.03 0.03 0.05 0.03 0.03 0.03 0.04 0.03 0.04 0.03 For Peer Review0.08 Only 0.03 0.05 0.03 0.02 0.03 0.11 0.03 0.02 0.03 0.1 0.03 0.02 0.03 0.03 0.03 0.07 0.03 0.04 0.03 0.03 0.03 0.03 0.03 0.08 0.03 0.04 0.03 0.03 0.03 0.07 0.03 0.07 0.03 0.07 0.03 0.03 0.03 0.04 0.03 0.07 0.03 0.02 0.03 0.06 0.03 0.03 0.03 0.03 0.03 0.07 0.03 0.03 0.03 0.05 0.03 0.07 0.03 0.05 0.03 0.1 0.03 0.07 0.03 0.04 0.03 0.05 0.03 0.03 0.03 0.07 0.03 0.04 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 719 of 848

0.03 0.03 0.02 0.03 0.04 0.03 0.02 0.03 0.07 0.03 0.03 0.03 0.07 0.03 0.06 0.03 0.03 0.03 0.03 0.03 For Peer Review0.05 Only 0.03 0.02 0.03 0 0.03 0.08 0.03 0.07 0.03 0.03 0.03 0.08 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.02 0.03 0.06 0.03 0.04 0.03 0.03 0.03 0.03 0.03 0.07 0.03 0.02 0.03 0.11 0.03 0.01 0.03 0.04 0.03 0.04 0.03 0.07 0.03 0.06 0.03 0.04 0.03 0.04 0.03 0.03 0.03 0.02 0.03 0.07 0.03 0.02 0.03 0.06 0.03 0.04 0.03 0.08 0.03 0.06 0.03 0.03 0.03 0.07 0.03 0.06 0.03 0.04 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 720 of 848

0.06 0.03 0.07 0.03 0.01 0.03 0.04 0.03 0.03 0.03 0.04 0.03 0.05 0.03 0.04 0.03 0.03 0.03 0.03 0.03 For Peer Review0.07 Only 0.03 0.08 0.03 0.02 0.03 0.06 0.03 0.02 0.03 0.06 0.03 0.05 0.03 0.03 0.03 0.02 0.03 0 0.03 0.02 0.03 0.04 0.03 0.03 0.03 0 0.03 0.02 0.03 0.05 0.03 0.02 0.03 0.04 0.03 0.02 0.03 0.02 0.03 0.02 0.03 0.02 0.03 0.03 0.03 0.03 0.03 0.02 0.03 0.04 0.03 0.04 0.03 0.01 0.03 0.02 0.03 0.02 0.03 0.05 0.03 0.06 0.03 0.1 0.03 0.02 0.03 0.06 0.03 0.05 0.03 0.06 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 721 of 848

0.03 0.03 0.03 0.03 0.01 0.03 0.02 0.03 0.05 0.03 0.02 0.03 0.03 0.03 0 0.03 0.05 0.03 0.07 0.03 For Peer Review0.05 Only 0.03 0.03 0.03 0.08 0.03 0.02 0.03 0.03 0.03 0.02 0.03 0.06 0.03 0 0.03 0.06 0.03 0.05 0.03 0.04 0.03 0.05 0.03 0.03 0.03 0.03 0.03 0.04 0.03 0.03 0.03 0.07 0.03 0.04 0.03 0.02 0.03 0.02 0.03 0.03 0.03 0.09 0.03 0.05 0.03 0.01 0.03 0.05 0.03 0.02 0.03 0.02 0.03 0.03 0.03 0.05 0.03 0.01 0.03 0.03 0.03 0.02 0.03 0.02 0.03 0.01 0.03 0.01 0.03 0.03 0.03 0.02 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 722 of 848

0.01 0.03 0.02 0.03 0.03 0.03 0.03 0.03 0.02 0.03 0.03 0.03 0.06 0.03 0.03 0.03 0.02 0.03 0.07 0.03 For Peer Review0.04 Only 0.03 0.06 0.03 0.03 0.03 0.02 0.03 0.07 0.03 0.02 0.03 0.02 0.03 0.03 0.03 0.05 0.03 0.05 0.03 0.03 0.03 0.02 0.03 0.02 0.03 0.03 0.03 0.01 0.03 0.02 0.03 0.03 0.03 0.02 0.03 0.02 0.03 0.03 0.03 0.02 0.03 0.02 0.03 0.02 0.03 0.05 0.03 0.05 0.03 0.03 0.03 0.04 0.03 0.04 0.03 0.06 0.03 0.06 0.03 0.06 0.03 0.03 0.03 0.03 0.03 0.04 0.03 0.02 0.03 0.03 0.03 0.02 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 723 of 848

0.05 0.03 0.01 0.03 0.03 0.03 0.06 0.03 0.02 0.03 0.02 0.03 0.04 0.03 0.02 0.03 0.08 0.03 0.07 0.03 For Peer Review0.04 Only 0.03 0.06 0.03 0.06 0.03 0.04 0.03 0.08 0.03 0.04 0.03 0.03 0.03 0.01 0.03 0.03 0.03 0.02 0.03 0.01 0.03 0.02 0.03 0.07 0.03 0.03 0.03 0.02 0.03 0.04 0.03 0.02 0.03 0.03 0.03 0.02 0.03 0.03 0.03 0.02 0.03 0.02 0.03 0.02 0.03 0.06 0.03 0.02 0.03 0.01 0.03 0 0.03 0.01 0.03 0.05 0.03 0.03 0.03 0.03 0.03 0.04 0.03 0.05 0.03 0.07 0.03 0.04 0.03 0.03 0.03 0.02 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 724 of 848

0.02 0.03 0.02 0.03 0.04 0.03 0.06 0.03 0.02 0.03 0.03 0.03 0.01 0.03 0.02 0.03 0.05 0.03 0.05 0.03 For Peer Review0.06 Only 0.03 0.02 0.03 0.01 0.03 0.03 0.03 0.07 0.03 0.04 0.03 0.01 0.03 0.04 0.03 0.02 0.03 0.05 0.03 0.01 0.03 0.03 0.03 0.05 0.03 0.07 0.03 0.02 0.03 0.07 0.03 0.02 0.03 0.03 0.03 0.05 0.03 0.06 0.03 0.04 0.03 0.02 0.03 0.05 0.03 0.02 0.03 0.02 0.03 0.04 0.03 0.01 0.03 0.01 0.03 0.02 0.03 0.04 0.03 0.01 0.03 0.05 0.03 0.04 0.03 0.05 0.03 0.05 0.03 0.01 0.03 0.02 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 725 of 848

0.03 0.03 0.03 0.03 0.04 0.03 0.05 0.03 0.02 0.03 0.02 0.03 0.04 0.03 0.04 0.03 0.04 0.03 0.03 0.03 For Peer Review0.04 Only 0.03 0.01 0.03 0.05 0.03 0.02 0.03 0.02 0.03 0.02 0.03 0.01 0.03 0.05 0.03 0.01 0.03 0.02 0.03 0.06 0.03 0.02 0.03 0.04 0.03 0.01 0.03 0.04 0.03 0.03 0.03 0.03 0.03 0.06 0.03 0.05 0.03 0 0.03 0.02 0.03 0.02 0.03 0.02 0.03 0.02 0.03 0.05 0.03 0.01 0.03 0.04 0.03 0.02 0.03 0.02 0.03 0.02 0.03 0.05 0.03 0.05 0.03 0.02 0.03 0.04 0.03 0.04 0.03 0.04 0.03 0.06 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 726 of 848

0.02 0.03 0.02 0.03 0.02 0.03 0.04 0.03 0.05 0.03 0.01 0.03 0.03 0.03 0.01 0.03 0.05 0.03 0.06 0.03 For Peer Review0.02 Only 0.03 0.03 0.03 0.02 0.03 0.05 0.03 0.03 0.03 0.02 0.03 0.01 0.03 0.01 0.03 0.01 0.03 0.02 0.03 0.04 0.03 0.02 0.03 0.01 0.03 0.04 0.03 0.04 0.03 0.03 0.03 0.01 0.03 0.03 0.03 0.02 0.03 0.02 0.03 0.06 0.03 0.01 0.03 0.06 0.03 0.01 0.03 0.04 0.03 0.01 0.03 0.03 0.03 0.02 0.03 0.03 0.03 0.07 0.03 0.02 0.03 0.03 0.03 0.03 0.03 0.02 0.03 0.04 0.03 0.02 0.03 0 0.03

Wiley-Blackwell and Society for Applied Microbiology Page 727 of 848

0.04 0.03 0.05 0.03 0.04 0.03 0.02 0.03 0.01 0.03 0.03 0.03 0.05 0.03 0.05 0.03 0.01 0.03 0.05 0.03 For Peer Review0.03 Only 0.03 0.02 0.03 0.05 0.03 0.01 0.03 0.02 0.03 0.02 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.04 0.02 0.07 0.02 0.02 0.02 0.04 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.03 0.02 0.05 0.02 0.04 0.02 0 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.05 0.02 0.02 0.02 0.02 0.02 0.05 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.03 0.02 0 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 728 of 848

0.04 0.02 0.02 0.02 0.03 0.02 0.03 0.02 0.03 0.02 0.02 0.02 0.04 0.02 0.05 0.02 0.02 0.02 0 0.02 For Peer Review0.02 Only 0.02 0.02 0.02 0.04 0.02 0.03 0.02 0.05 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.05 0.02 0.03 0.02 0.02 0.02 0.05 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.06 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.05 0.02 0.06 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.05 0.02 0.01 0.02 0.03 0.02 0.02 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 729 of 848

0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.05 0.02 0.05 0.02 0.06 0.02 0.02 0.02 For Peer Review0.04 Only 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.09 0.02 0.02 0.02 0.03 0.02 0.03 0.02 0.05 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.04 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.05 0.02 0.04 0.02 0.02 0.02 0.05 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0.07 0.02 0.02 0.02 0.02 0.02 0.03 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 730 of 848

0.01 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.04 0.02 0 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.04 0.02 For Peer Review0.02 Only 0.02 0.06 0.02 0.05 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.04 0.02 0.07 0.02 0.02 0.02 0.05 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.06 0.02 0.04 0.02 0.02 0.02 0.05 0.02 0.02 0.02 0.03 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0.04 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 731 of 848

0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.05 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.01 0.02 For Peer Review0.04 Only 0.02 0.02 0.02 0.05 0.02 0.04 0.02 0.02 0.02 0.05 0.02 0.02 0.02 0.04 0.02 0.06 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.05 0.02 0.04 0.02 0.04 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.04 0.02 0.04 0.02 0.03 0.02 0.01 0.02 0.02 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 732 of 848

0.02 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.06 0.02 0.04 0.02 0.05 0.02 0.02 0.02 0.02 0.02 For Peer Review0.02 Only 0.02 0.03 0.02 0.01 0.02 0 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.05 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0 0.02 0.02 0.02 0.01 0.02 0.04 0.02 0.03 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0.04 0.02 0.03 0.02 0.03 0.02 0.02 0.02 0.05 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 733 of 848

0.02 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.04 0.02 For Peer Review0.02 Only 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.05 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.06 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.04 0.02 0.07 0.02 0.02 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.05 0.02 0.05 0.02 0.02 0.02 0.02 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 734 of 848

0.03 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.04 0.02 0.03 0.02 0.02 0.02 For Peer Review0.01 Only 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.05 0.02 0.03 0.02 0.02 0.02 0 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0 0.02 0.02 0.02 0.01 0.02 0 0.02 0.03 0.02 0.02 0.02 0.04 0.02 0.03 0.02 0.03 0.02 0.04 0.02 0.04 0.02 0.03 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.03 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 735 of 848

0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.04 0.02 0.03 0.02 0.01 0.02 For Peer Review0.01 Only 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.03 0.02 0.04 0.02 0.04 0.02 0.02 0.02 0 0.02 0.03 0.02 0.03 0.02 0.03 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.05 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.04 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 736 of 848

0.01 0.02 0.05 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.03 0.02 For Peer Review0.01 Only 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.04 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 737 of 848

0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.05 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 For Peer Review0.03 Only 0.02 0 0.02 0.01 0.02 0 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.04 0.02 0.04 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.04 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 738 of 848

0.03 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.03 0.02 For Peer Review0.03 Only 0.02 0 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.04 0.02 0.01 0.02 0.06 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.04 0.02 0.01 0.02 0.03 0.02 0.04 0.02 0.01 0.02 0.01 0.02 0.02 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 739 of 848

0.02 0.02 0.05 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 For Peer Review0 Only 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.04 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.03 0.02 0.03 0.02 0.04 0.02 0.01 0.02 0.03 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 740 of 848

0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 For Peer Review0.07 Only 0.02 0.03 0.02 0.04 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.05 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 741 of 848

0.02 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.03 0.02 For Peer Review0.01 Only 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0 0.02 0 0.02 0.04 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0 0.02 0.02 0.02 0.01 0.02 0.04 0.02 0 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.03 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 742 of 848

0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 For Peer Review0.02 Only 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.04 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.04 0.02 0 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.04 0.02 0.03 0.02 0.03 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 743 of 848

0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 For Peer Review0.02 Only 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.03 0.02 0.03 0.02 0.03 0.02 0.01 0.02 0 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.04 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.04 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 744 of 848

0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.04 0.02 For Peer Review0.02 Only 0.02 0.03 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.03 0.02 0 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.04 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 745 of 848

0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.03 0.02 0.01 0.02 For Peer Review0.01 Only 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0 0.02 0.02 0.02 0.01 0.02 0.04 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 746 of 848

0.02 0.02 0.01 0.02 0.02 0.02 0 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.04 0.02 For Peer Review0.03 Only 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.02 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 747 of 848

0.01 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 For Peer Review0.01 Only 0.02 0.03 0.02 0 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0.03 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.03 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 748 of 848

0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 For Peer Review0.02 Only 0.02 0.02 0.02 0 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.02 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 749 of 848

0.03 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.04 0.02 0.01 0.02 0.01 0.02 For Peer Review0.01 Only 0.02 0.01 0.02 0 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.05 0.02 0.03 0.02 0.03 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 750 of 848

0.03 0.02 0.01 0.02 0.02 0.02 0.04 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.03 0.02 For Peer Review0.01 Only 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.03 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0.03 0.02 0.01 0.02 0 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0.01 0.02 0 0.02 0.01 0.02 0.03 0.02 0.03 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.02 0.01 0.02 0 0.02 0.01 0.02 0 0.02 0.03 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.01 0.02 0.01 0.02

Wiley-Blackwell and Society for Applied Microbiology Page 751 of 848

0.01 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.01 0.02 0.03 0.02 0.01 0.01 0.01 0.01 0.03 0.01 0.02 0.01 For Peer Review0.02 Only 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.04 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 0.03 0.01 0.03 0.01 0.03 0.01 0.01 0.01 0.03 0.01 0.03 0.01 0.01 0.01 0.03 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.03 0.01 0 0.01 0.01 0.01 0.01 0.01 0.03 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 752 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0 0.01 0.01 0.01 0.03 0.01 For Peer Review0.01 Only 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.03 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 753 of 848

0.02 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 For Peer Review0.01 Only 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0 0.01 0.03 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.03 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.04 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0.03 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 754 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 For Peer Review0.03 Only 0.01 0.03 0.01 0 0.01 0.03 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.04 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0 0.01 0.02 0.01 0.03 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 755 of 848

0.03 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.04 0.01 0 0.01 0 0.01 0.03 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 756 of 848

0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 757 of 848

0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 For Peer Review0.01 Only 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.02 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 758 of 848

0.03 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.03 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.03 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 759 of 848

0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 For Peer Review0.02 Only 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.03 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 760 of 848

0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.03 0.01 0 0.01 0.01 0.01 0.03 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.02 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 761 of 848

0 0.01 0.02 0.01 0.01 0.01 0 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.03 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 762 of 848

0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.03 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 763 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 764 of 848

0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.03 0.01 0.02 0.01 For Peer Review0.03 Only 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 765 of 848

0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 For Peer Review0.02 Only 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 766 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.02 0.01 0 0.01 0 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 767 of 848

0.01 0.01 0.01 0.01 0.02 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 768 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0.03 0.01 0.01 0.01 0.02 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 769 of 848

0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0 Only 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 770 of 848

0.01 0.01 0.01 0.01 0.03 0.01 0 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.03 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 771 of 848

0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 For Peer Review0.01 Only 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 772 of 848

0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 For Peer Review0 Only 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.03 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 773 of 848

0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 774 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 For Peer Review0 Only 0.01 0.02 0.01 0 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 775 of 848

0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 776 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 For Peer Review0 Only 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 777 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 778 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 0 0.01 0.02 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 779 of 848

0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0 Only 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.02 0.01 0 0.01 0 0.01 0.03 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 780 of 848

0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0.02 Only 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 781 of 848

0.02 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 782 of 848

0.01 0.01 0.02 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 For Peer Review0.02 Only 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 783 of 848

0.01 0.01 0 0.01 0 0.01 0.02 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 784 of 848

0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 785 of 848

0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 For Peer Review0 Only 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 786 of 848

0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 787 of 848

0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 788 of 848

0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 789 of 848

0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 For Peer Review0 Only 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 790 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 791 of 848

0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 For Peer Review0.01 Only 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 792 of 848

0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 793 of 848

0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 794 of 848

0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 For Peer Review0 Only 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 795 of 848

0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 796 of 848

0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 797 of 848

0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 798 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 799 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 800 of 848

0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 801 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0.01 Only 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.02 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 802 of 848

0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 803 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 804 of 848

0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 805 of 848

0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 806 of 848

0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 For Peer Review0.01 Only 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 807 of 848

0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 For Peer Review0 Only 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 808 of 848

0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 809 of 848

0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 810 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 811 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 812 of 848

0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 For Peer Review0 Only 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0.01 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01 0.01 0.01 0 0.01 0 0.01

Wiley-Blackwell and Society for Applied Microbiology Page 813 of 848

0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0.01 0 0 For Peer Review0.01 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 814 of 848

0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 815 of 848

0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 816 of 848

0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 817 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 818 of 848

0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 819 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 820 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 821 of 848

0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 822 of 848

0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0.01 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 823 of 848

0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 824 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 825 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0.01 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 826 of 848

0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 827 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 828 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 829 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 830 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 831 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 832 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 833 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 834 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 835 of 848

0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 836 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 837 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.01 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 838 of 848

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 For Peer Review0 Only 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Wiley-Blackwell and Society for Applied Microbiology Page 839 of 848

Table S6. Contributions of KEGG modules to variance between the North and South zones. KEGG module Average abundance North (standardised and log transformed) Photosystem II 0.57 Complex I (NADH dehydrogenase), NADH dehydrogenase I/diaphorase subunit of0.24 the bidirectional hydrogenase Photosystem I 0.34 Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP0.66 Histidine degradation, histidine => N-formiminoglutamate => glutamate 0.31 Methionine salvage pathway 0.43 sn-Glycerol 3-phosphate transport system 0.16 Complex I (NADH dehydrogenase), NADH dehydrogenase I 1.05 Branched-chain aminoFor acid transport Peer system Review Only0.83 Dipeptide transport system 0.02 Adenine nucleotide biosynthesis, IMP => ADP/dADP,ATP/dATP 0.74 Glycine betaine/proline transport system 0.56 Sulfur reduction, sulfate => H2S 0.44 Simple sugar transport system 0.39 Peptides/nickel transport system 0.98 Ribosome, eukaryotes 0.27 Multiple sugar transport system 0.55 Type II general secretion system 0.21 Sulfonate/nitrate/taurine transport system 0.37 Guanine nucleotide biosynthesis, IMP => GDP/dGDP,GTP/dGTP 0.82 RNA polymerase II, eukaryotes 0.2 Histidine biosynthesis, PRPP => histidine 0.86 Putrescine transport system 0.09 Leucine biosynthesis, pyruvate => 2-oxoisovalerate => leucine 1.37 C5 isoprenoid biosynthesis, non-mevalonate pathway 0.77 Leucine degradation, leucine => acetoacetate + acetyl-CoA 0.59 Thiamine transport system 0.05 Spliceosome, 35S U5-snRNP 0.2 Cytochrome b6f complex 0.12 Menaquinone biosynthesis, chorismate => menaquinone 0.27 beta-Alanine biosynthesis, cytosine / uracil => beta-alanine 0.16 Proteasome, 19S regulatory particle (PA700) 0.16 Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP 1.14 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA 0.47 Phosphate transport system 0.2 beta-Carotene biosynthesis, GGAP => beta-carotene 0.44 Putative spermidine/putrescine transport system 0.34 Iron(III) transport system 0.46 Thiamine biosynthesis, AIR => thiamine-P/thiamine-2P 0.16 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate 0.22 RNA polymerase, bacteria 1.27 Biotin biosynthesis, pimeloyl-CoA => biotin 0.16 Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate 0.15 Polar amino acid transport system 0.2 Ribosome, bacteria 1.46

Wiley-Blackwell and Society for Applied Microbiology Page 840 of 848

Ubiquinone biosynthesis, prokaryotes, chorismate => ubiquinone 0.63 Pyridoxal biosynthesis, erythrose-4P => pyridoxal-5P 0.38 Zinc transport system 0.22 General L-amino acid transport system 0.39 Reductive citric acid cycle (Arnon-Buchanan cycle) 0.71 Methionine biosynthesis, apartate => homoserine => methionine 0.67 GABA (gamma-Aminobutyrate) shunt 0.28 indolepyruvate:ferredoxin oxidoreductase 0.09 Lysine biosynthesis, aspartate => lysine 0.86 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine 0.3 Triacylglycerol biosynthesisFor Peer Review Only0.29 C5 isoprenoid biosynthesis, mevalonate pathway 0.18 Fatty acid biosynthesis, elongation 0.66 Molybdate transport system 0.1 Ribosome, archaea 0.94 Cobalamin biosynthesis, cobinamide => cobalamin 0.25 Complex IV (Cytochrome c oxidase), cytochrome o ubiquinol oxidase/cytochrome0.75 c oxidase/quinol oxidase polypeptide Hydroxypropionate-hydroxybutylate cycle 0.55 Spliceosome, U4/U6.U5 tri-snRNP 0.16 Iron complex transport system 0.2 Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA 0.26 Threonine biosynthesis, apartate => homoserine => threonine 0.46 Coenzyme M biosynthesis 0.04 C4-dicarboxylic acid cycle, NAD+ -malic enzyme type 0.27 GABA biosynthesis, eukaryotes, putrescine => GABA 0.46 Zinc/manganese transport system 0.07 Lipopolysaccharide biosynthesis, KDO2-lipid A 0.65 Urea transport system 0.06 Tryptophan biosynthesis, chorismate => tryptophan 0.75 Inosine monophosphate biosynthesis, PRPP + glutamine => IMP 1.27 Sorbitol/mannitol transport system 0.12 Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) 0.44 Lignin biosynthesis, cinnamate => lignin 0.18 Ethylmalonyl pathway 0.28 Nucleotide sugar biosynthesis, prokaryotes 0.39 Heme biosynthesis, glutamate => protoheme/siroheme 0.63 Glutathione biosynthesis, glutamate => glutathione 0.27 D-Xylose transport system 0.06 V-type ATPase, eukaryotes 0.09 Octopine/nopaline transport system 0.1 Cytochrome bd complex 0.07 Coenzyme A biosynthesis, pantothenate => CoA 0.41 Cysteine biosynthesis, serine => cysteine 0.33 Tetrahydrofolate biosynthesis, GTP => THF 0.53 Methionine degradation 0.51 Urea cycle 0.45 3-Hydroxypropionate bicycle 0.52

Wiley-Blackwell and Society for Applied Microbiology Page 841 of 848

F-type ATPase, bacteria 0.64 ATP synthase 0.64 MCM complex 0.1 DNA polymerase III complex, bacteria 1.09 Citrate cycle (TCA cycle, Krebs cycle) 0.76 V-type ATPase, prokaryotes 0.03 Keratan sulfate degradation 0.08 Creatine pathway 0.11 Complex III (Cytochrome bc1 complex) 0.39 Lipopolysaccharide export system 0.28 Methane oxidation, Formethylotroph, Peer methane => CO2Review Only0.36 beta-Oxidation 0.42 Phosphonate transport system 0.14 Complex IV (Cytochrome c oxidase), cytochrome c oxidase, cbb3-type 0.05 Aminoacyl-tRNA biosynthesis, eukaryotes 1.46 ABC-2 type transport system 0.15 Citrate cycle, first carbon oxidation 0.34 Spliceosome, U2-snRNP 0.07 Uronic acid metabolism 0.15 Putative ABC transport system 0.19 Aminoacyl-tRNA biosynthesis, prokaryotes 1.6 NAD biosynthesis, aspartate => NAD 0.52 Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate 0.79 Glucuronate pathway (uronate pathway) 0.16 Methanogenesis, formate => methane 0.19 C1-unit interconversion, prokaryotes 0.28 Ribose transport system 0.06 Serine biosynthesis, glycerate-3P => serine 0.37 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP 0.39 (Embden-Meyerhof pathway), glucose => pyruvate 0.56 Histidine transport system 0 RNA polymerase, archaea 0.03 Lipoprotein-releasing system 0.18 Pyruvate oxidation, pyruvate => acetyl-CoA 0.78 beta-Oxidation, acyl-CoA synthesis 0.28 Rhamnose transport system 0.05 C4-dicarboxylic acid cycle, NADP+ -malic enzyme type 0.29 Glyoxylate cycle 0.58 Sec (secretion) system 1.25 Polyamine biosynthesis, arginine => ornithine => putrescine 0.11 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE 0.23 CAM (Crassulacean acid metabolism), light 0.27 Tyrosine biosynthesis, chorismate => tyrosine 0.26 Uncharacterized ABC transport system 0.47 Fatty acid biosynthesis, initiation 0.57 Manganese/iron transport system 0.14 PRPP biosynthesis, ribose 5P => PRPP 0.21

Wiley-Blackwell and Society for Applied Microbiology Page 842 of 848

Ornithine biosynthesis, glutamate => ornithine 0.51 Antibiotic transport system 0.29 GABA biosynthesis, prokaryotes, putrescine => GABA 0.1 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol 0.21 Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone0.14 RNA polymerase III, eukaryotes 0.06 Complex I (NADH dehydrogenase), NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein0.08 Heme transport system 0.15 Type VI secretion system 0.07 Complex IV (Cytochrome c oxidase), cytochrome c oxidase 0.23 Riboflavin biosynthesis,For GTP => riboflavin/FMN/FADPeer Review Only0.38 Cell division transport system 0.09 Pantothenate biosynthesis, valine/L-aspartate => pantothenate 0.26 Dicarboxylate-hydroxybutyrate cycle 0.51 Lactose/L-arabinose transport system 0.04 Citrate cycle, second carbon oxidation 0.57 Proline biosynthesis, glutamate => proline 0.4 Lysine biosynthesis, archaea, 2-aminoadipate => lysine 0.15 Formaldehyde assimilation, serine pathway 0.27 Twin-arginine translocation (Tat) system 0.17 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 0.03 Reductive pentose phosphate cycle (Calvin cycle) 0.31 Putative tungstate transport system 0.07 Ascorbate biosynthesis, animals, glucose-1P => ascorbate 0.13 Sodium transport system 0.04 , oxaloacetate => fructose-6P 0.48 BRCA1-associated genome surveillance complex (BASC) 0.08 Oligosaccharyltransferase 0.05 C4-dicarboxylic acid cycle, phosphoenolpyruvate carboxykinase type 0.26 Nucleotide sugar biosynthesis, eukaryotes 0.19 CMP-KDO biosynthesis 0.24 ADP-L-glycero-D-manno-heptose biosynthesis 0.08 Lysine/arginine/ornithine transport system 0 Tyrosine degradation, tyrosine => homogentisate 0.05 Acylglycerol degradation 0.04 RNA polymerase I, eukaryotes 0.05 Glycolysis, core module involving three-carbon compounds 0.4 Spermidine/putrescine transport system 0.05 Capsular polysaccharide transport system 0.05 Abscisic acid biosynthesis, beta-carotene => abscisic acid 0.03 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P 0.15 Holo-TFIIH complex 0.05 Reductive pentose phosphate cycle, RuBP + CO2 => glyceraldehyde-3P 0.09 Flavonoid biosynthesis, 4-coumaroyl-CoA => naringenin => apigenin 0.05 C1-unit interconversion, eukaryotes 0.11 Spliceosome, Prp19/CDC5L complex 0.06 Type IV secretion system 0.04

Wiley-Blackwell and Society for Applied Microbiology Page 843 of 848

F-type ATPase, eukaryotes 0.04 Proteasome, 20S core particle 0.05 Formaldehyde assimilation, xylulose monophosphate pathway 0.06

For Peer Review Only

Wiley-Blackwell and Society for Applied Microbiology Page 844 of 848

Contributions of KEGG modules to variance between the North and South zones. Average abundance South (standardised and log transformed) Contribution to variance (%) 0.42 2.21 0.01 1.8 0.43 1.7 0.51 1.16 0.42 1.14 0.29 1.14 0.29 1.11 1.08 1.06 For Peer Review0.79 Only 0.96 0.14 0.95 0.62 0.95 0.66 0.94 0.54 0.91 0.46 0.9 0.99 0.89 0.26 0.89 0.55 0.86 0.21 0.82 0.45 0.82 0.72 0.81 0.11 0.76 0.94 0.76 0.18 0.72 1.29 0.71 0.7 0.71 0.64 0.71 0.13 0.69 0.18 0.68 0.14 0.67 0.25 0.66 0.24 0.66 0.14 0.66 1.07 0.65 0.53 0.63 0.16 0.63 0.4 0.63 0.39 0.62 0.48 0.6 0.11 0.6 0.26 0.6 1.23 0.6 0.17 0.6 0.21 0.59 0.23 0.59 1.52 0.58

Wiley-Blackwell and Society for Applied Microbiology Page 845 of 848

0.68 0.58 0.44 0.57 0.27 0.55 0.39 0.55 0.67 0.55 0.74 0.54 0.22 0.54 0.15 0.53 0.87 0.53 0.25 0.53 For Peer Review0.23 Only 0.53 0.23 0.52 0.61 0.52 0.15 0.52 0.98 0.51 0.3 0.51 0.81 0.51 0.59 0.51 0.13 0.5 0.19 0.5 0.31 0.49 0.48 0.49 0.1 0.48 0.22 0.47 0.49 0.47 0.01 0.46 0.65 0.46 0 0.46 0.78 0.46 1.25 0.45 0.14 0.45 0.47 0.45 0.14 0.45 0.3 0.45 0.35 0.44 0.67 0.44 0.33 0.44 0.08 0.43 0.12 0.43 0.07 0.42 0.02 0.41 0.39 0.41 0.35 0.41 0.51 0.4 0.47 0.39 0.48 0.39 0.54 0.39

Wiley-Blackwell and Society for Applied Microbiology Page 846 of 848

0.61 0.39 0.61 0.39 0.07 0.39 1.11 0.39 0.72 0.39 0.04 0.39 0.09 0.38 0.08 0.38 0.4 0.38 0.27 0.38 For Peer Review0.38 Only 0.38 0.44 0.37 0.14 0.37 0.03 0.37 1.47 0.37 0.18 0.36 0.3 0.36 0.06 0.36 0.12 0.36 0.16 0.36 1.61 0.36 0.51 0.36 0.77 0.35 0.12 0.35 0.22 0.35 0.27 0.35 0.08 0.34 0.4 0.34 0.35 0.34 0.56 0.34 0.04 0.34 0.03 0.34 0.21 0.34 0.81 0.33 0.3 0.33 0.04 0.33 0.26 0.32 0.61 0.32 1.26 0.32 0.08 0.31 0.27 0.31 0.25 0.31 0.24 0.31 0.45 0.3 0.55 0.3 0.13 0.3 0.19 0.3

Wiley-Blackwell and Society for Applied Microbiology Page 847 of 848

0.55 0.3 0.27 0.3 0.12 0.3 0.18 0.3 0.16 0.29 0.07 0.29 0.07 0.29 0.16 0.29 0.05 0.29 0.24 0.29 For Peer Review0.37 Only 0.28 0.11 0.28 0.27 0.28 0.49 0.28 0 0.28 0.55 0.28 0.41 0.28 0.19 0.28 0.29 0.27 0.17 0.27 0.06 0.27 0.29 0.27 0.1 0.27 0.1 0.26 0.07 0.26 0.51 0.26 0.08 0.26 0.05 0.26 0.23 0.26 0.17 0.26 0.26 0.25 0.06 0.24 0.03 0.24 0.07 0.24 0.01 0.24 0.05 0.24 0.41 0.24 0.07 0.23 0.02 0.23 0 0.22 0.16 0.22 0.04 0.22 0.08 0.22 0.06 0.22 0.09 0.22 0.04 0.2 0.02 0.2

Wiley-Blackwell and Society for Applied Microbiology Page 848 of 848

0.03 0.2 0.05 0.2 0.07 0.2

For Peer Review Only

Wiley-Blackwell and Society for Applied Microbiology