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Cancer Overview Prediction of Melting Point Lowering in Eutectic Mixtures Item Type text; Electronic Dissertation Authors Aldhubiab, Bandar Essa Publisher The University of Arizona. Rights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Download date 28/09/2021 06:38:43 Link to Item http://hdl.handle.net/10150/195415 1 PREDICTION OF MELTING POINT LOWERING IN EUTECTIC MIXTURES By Bandar Aldhubiab ___________________________ A Dissertation Submitted to the Faculty of the DEPARTMENT OF PHARMACEUTICAL SCIENCES In Partial Fulfillment of the Requirements For the degree of DOCTOR OF PHILOSOPHY In the Graduate College THE UNIVERSITY OF ARIZONA 2010 2 THE UNIVERSITY OF ARIZONA GRADUATE COLLEGE As members of the Dissertation Committee, we certify that we have read the dissertation prepared by Bandar Aldhubiab entitled Prediction of the melting point lowering in the eutectic mixture and recommend that it be accepted as fulfilling the dissertation requirement for the Degree of Doctor of Philosophy ______________________________________________________________ Date: May 11 2010 Dr. Samuel H Yalkowsky ______________________ _________________________________________ Date: May 11 2010 Dr. Michael Mayersohn _______________________________________________________________ Date: May 11 2010 Dr. Paul Myrdal _______________________________________________________________ Date: _________________________________________________________________ Date: Final approval and acceptance of this dissertation is contingent upon the candidate’s submission of the final copies of the dissertation to the Graduate College. I hereby certify that I have read this dissertation prepared under my direction and recommend that it be accepted as fulfilling the dissertation requirement. ________________________________________ Date: May 11 2010 Dissertation Director: Dr. Samuel H Yalkowsky 3 STATEMENT BY AUTHOR This dissertation has been submitted in partial fulfillment of requirements for an advanced degree at The University of Arizona and is deposited in the University Library to be made available to borrowers under rules of the Library. Brief quotations from this thesis are allowable without special permission provided that accurate acknowledgment of source is made. Requests for permission for extended quotation from or reproduction of this manuscript in whole or in part may be granted by the head of the major department or the Dean of Graduate College when in his or her judgment the proposed use of the material is in the interests of scholarship. In all other instances, however, permission must be obtained from the author. SIGNED:__BANDAR ALDHUBIAB________________________________ 4 ACKNOWLEDGEMENTS I would first like to thank my advisor, Dr. Samuel H. Yalkowsky. Throughout my doctoral degree, he taught me behavioral and technical skills, enhanced my critical thinking, and provided guidance for my scientific writings and presentations. Besides always being there for me as an academic advisor, he has also acted as a philosophical advisor and life coach. In further appreciation, I would like to express my sincerest thanks to Dr. Mayersohn, Dr. Myrdal, and Dr. Murphy for offering their valuable time to serve on my committee. Their involvement and feedback are truly appreciated. My thanks continues to my lab mates, Dr. Duoli Guo, Dr. Katherine Chu, and Dr. Parijat Jain for their ongoing support during my PhD degree. I will also not forget Abdull-qadir Khan for helping me finish my experiments. These individuals never hesitated to help me and I consider them like family. I have deepest gratitude toward my father and mother who have taught me the basics of life. Their teachings have played an important role in my education. I learned from my father to persevere to achieve my goals. He also encouraged me throughout my graduate studies. 5 Finally, I would like to thank my lovely wife, Asma, without her support, this would not have been possible. I would also like to thank my best friend and neighbor, Dr. Khalid Alghanem, for being there for me, especially for my last year of study. I am grateful for the valuable advice that he gave me. 6 DEDICATION TO MY FAMILY 7 TABLE OF CONTENTS LIST OF FIGURES .......................................................................................................9 LIST OF TABLES ....................................................................................................... 11 ABSTRACT ................................................................................................................. 12 CHAPTER I: INTRODUCTION TO PEG 400 EUTECTIC MIXTURES ............... 13 1.1. Background(Methods)……………………………………………………………15 1.2. Carriers (Polymers)……………………………………………………………….16 CHAPTER II: THEORY ............................................................................................ 18 2.1. Ideal Solution Model:……………………………………………………...…….18 2.2. Regular Solution Model:……………………………………………………...….20 2.3. Quasi-Regular Solution Model:……………………………………………….....24 CHAPTER III: EXPERIMENTAL SECTION .......................................................... 27 3.1. Materials:………………………………………...………………………………27 3.2. Methods:…………………………………………...…………………………….27 3.3. Physical Properties:…………………………………...………………………….28 CHAPTER IV: RESULTS AND DISCUSSION ........................................................ 30 4.1. Assigning a value of N for PEG-400:………………………...………………….30 4.2. Eutectic diagram:……………………...…………………………………………32 4.3. Ideal Solution Model:…...……………………………………………………….42 8 4.4. Regular Solution Model:………………………………………………………….42 4.5. Quasi-Regular Solution Model:…………………………………………………..42 CHAPTER V: INTRODUCTION TO PEG 4000 EUTECTIC MIXTURES............ 45 5.1. Background…….…………………………………………………………………46 5.2.Ideal Solution Model:…..…………………………………………………………46 5.3.Regular Solution Model:…………………...……………………………………...46 5.4.Quasi-Regular Solution Model:………...…………………………………………47 5.5.Experimental section:…….………..………………………………………………49 5.5.1.Materials: ...................................................................................................... 49 5.5.2.DSC study: .................................................................................................... 49 5.5.3.TGA: ............................................................................................................. 50 5.6.Drug Properties:…………………………………………………………..………50 CHAPTER VI: RESULTS AND DISCUSSION ........................................................ 51 SUMMARY ................................................................................................................. 62 REFERENCES ............................................................................................................ 64 9 LIST OF FIGURES Figure 1. a typical phase diagram illustrating a eutectic mixture..................................... 14 Figure 2. Dependence of average absolute error of Tmix at 50% drug load for 9 drugs on the effective number of repeating segments of PEG-400. ............................................... 31 Figure 3. Tmix of 1-Naphthoic acid and PEG 400.......................................................... 33 Figure 4. Tmix of Estrone and PEG 400 ........................................................................ 34 Figure 5. Tmix of Griseofulvin and PEG 400 ................................................................. 35 Figure 6. Tmix of Indomethacin and PEG 400. .............................................................. 36 Figure 7. Tmix of Naproxen and PEG 400 ..................................................................... 37 Figure 8. Tmix of Phenobarbital and PEG 400 ............................................................... 38 Figure 9. Tmix of Paracetamol and PEG 400 ................................................................. 39 Figure 10. Tmix of Salicylamide and PEG 400 .............................................................. 40 Figure 11. Tmix of Salicylic acid and PEG 400 ............................................................. 41 Figure 12. Tmix of 1-Naphthoic acid and PEG 4000 ...................................................... 53 Figure 13. Tmix of Estrone and PEG 4000..................................................................... 54 Figure 14. Tmix of Griseofulvin and PEG 4000 ............................................................. 55 Figure 15. Tmix of Indomethacin and PEG 4000 ........................................................... 56 Figure 16. Tmix of Naproxen and PEG 4000 ................................................................. 57 Figure 17. Tmix of Phenobarbital and PEG 4000 ........................................................... 58 Figure 18. Tmix of Paracetamol and PEG 4000 ............................................................. 59 10 Figure 19. Tmix of Salicylamide and PEG 4000 ............................................................ 60 Figure 20. Tmix of Salicylic acid and PEG 4000 ........................................................... 61 11 LIST OF TABLES Table 1. List of Physical Properties ............................................................................... 29 Table 2. Observed and Predicted Melting Temperatures Tmix for 50 %(w/w) Drug-PEG 400 Mixtures:. ..............................................................................................................
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