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CredibleMeds Filtered QTDrug List

The last revision date: September, 10th 2020

See Note below for safe use of this Table

The drug list below contains drugs from the categories: Known Risk of TdP AND filtered by Keyword --> " "

Generic Name Brand Names (Partial List) Drug Class Therapeutic Use Risk Category Route

Aclarubicin (Only Aclacin, Aclacinomycine, Anti-cancer Cancer Risk of injection on Non US Aclacinon, Aclaplastin, TdPAnd Avoid Market) Jaclacin in congenital long QT Cordarone, Pacerone, Antiarrhythmic Arrhythmia Risk of oral, injection Nexterone TdPAnd Avoid in congenital long QT Anagrelide Agrylin, Xagrid Phosphodiesterase 3 Thrombocythemia Risk of oral inhibitor TdPAnd Avoid in congenital long QT Arsenic trioxide Trisenox Anti-cancer Cancer (leukemia) Risk of injection TdPAnd Avoid in congenital long QT Hismanal Allergic rhinitis Risk of oral (Removed from TdPAnd Avoid US Market) in congenital long QT Azithromycin Zithromax, Zmax Antibiotic Bacterial infection Risk of oral, injection TdPAnd Avoid in congenital long QT Bepridil Vascor Antianginal Angina Pectoris (heart Risk of oral pain) TdPAnd Avoid in congenital long QT Cesium Chloride Energy Catalyst Toxin Alternative therapy Risk of oral, injection cancer TdPAnd Avoid in congenital long QT Chloroquine Aralen Antimalarial Malaria Risk of oral TdPAnd Avoid in congenital long QT

Generic Name Brand Names (Partial List) Drug Class Therapeutic Use Risk Category Route

Chlorpromazine Thorazine, Largactil, Antipsychotic / Nausea, Schizophrenia, Risk of oral, Megaphen Antiemetic many others TdPAnd Avoid injection, in congenital suppository long QT Truxal Antipsychotic Schizophrenia Risk of oral, injection (Only on Non US TdPAnd Avoid Market) in congenital long QT Cilostazol Pletal Phosphodiesterase 3 Intermittent claudication Risk of oral inhibitor TdPAnd Avoid in congenital long QT Cipro, Cipro-XR, Neofloxin Antibiotic Bacterial infection Risk of oral, injection TdPAnd Avoid in congenital long QT Propulsid GI stimulant Increase GI motility Risk of oral (Removed from TdPAnd Avoid US Market) in congenital long QT Citalopram Celexa, Cipramil , SSRI Depression Risk of oral TdPAnd Avoid in congenital long QT Clarithromycin Biaxin, Prevpac Antibiotic Bacterial infection Risk of oral, inhaled TdPAnd Avoid in congenital long QT Cocaine Local (topical) Risk of oral, nasal TdPAnd Avoid in congenital long QT Norpace Antiarrhythmic Arrhythmia Risk of oral, injection TdPAnd Avoid in congenital long QT Tikosyn Antiarrhythmic Arrhythmia Risk of oral TdPAnd Avoid in congenital long QT Domperidone Motilium, Motillium, Motinorm Antiemetic Nausea, vomiting Risk of oral, (Only on Non US Costi, Nomit TdPAnd Avoid injection, Market) in congenital suppository long QT Donepezil Aricept Dementia (Alzheimer's Risk of oral inhibitor Disease) TdPAnd Avoid in congenital long QT

Generic Name Brand Names (Partial List) Drug Class Therapeutic Use Risk Category Route

Dronedarone Multaq Antiarrhythmic Arrhythmia Risk of oral TdPAnd Avoid in congenital long QT Inapsine, Droleptan, Dridol, Antipsychotic / Anesthesia (adjunct), Risk of injection Xomolix Antiemetic nausea TdPAnd Avoid in congenital long QT Erythromycin E.E.S., Robimycin, EMycin, Antibiotic Bacterial infection, Risk of oral, injection Erymax, Ery-Tab, Eryc increase GI motility TdPAnd Avoid Ranbaxy, Erypar, Eryped, in congenital Erythrocin Stearate Filmtab, long QT Erythrocot, E-Base, Erythroped, Ilosone, MY-E, Pediamycin, Abboticin, Abboticin-ES, Erycin, PCE Dispertab, Stiemycine, Acnasol, Tiloryth Escitalopram Cipralex, Lexapro, Nexito, Antidepressant, SSRI Depression (major), Risk of oral Anxiset-E, Exodus, Esto, anxiety disorders TdPAnd Avoid Seroplex, Elicea, Lexamil, in congenital Lexam, Entact, Losita, long QT Reposil, Animaxen, Esitalo, Lexamil Tambocor, Almarytm, Antiarrhythmic Arrhythmia Risk of oral Apocard, Ecrinal, Flécaine TdPAnd Avoid in congenital long QT Fluconazole Diflucan, Trican Antifungal Fungal infection Risk of oral, injection TdPAnd Avoid in congenital long QT Gatifloxacin Tequin Antibiotic Bacterial infection Risk of oral, injection (Removed from TdPAnd Avoid US Market) in congenital long QT Grepafloxacin Raxar Antibiotic Bacterial infection Risk of oral (Removed from TdPAnd Avoid US Market) in congenital long QT Halofantrine Halfan Antimalarial Malaria Risk of oral (Only on Non US TdPAnd Avoid Market) in congenital long QT Haldol, Aloperidin, Antipsychotic Schizophrenia, agitation Risk of oral, injection Bioperidolo, Brotopon, Dozic, TdPAnd Avoid Duraperidol, Einalon S, in congenital Eukystol, Halosten, Keselan, long QT Linton, Peluces, Serenace, Serenase, Sigaperidol

Generic Name Brand Names (Partial List) Drug Class Therapeutic Use Risk Category Route

Hydroquinidine Serecor Antiarrhythmic Arrhythmia Risk of oral (Dihydroquinidine) TdPAnd Avoid (Only on Non US in congenital Market) long QT Hydroxychloroqui Plaquenil, Quineprox Antimalarial, Malaria, SLE, Risk of oral ne Anti-inflammatory rheumatoid arthritis TdPAnd Avoid in congenital long QT (Only on Psychedelic Narcotic addiction, Risk of oral Non US Market) unproven TdPAnd Avoid in congenital long QT Corvert Antiarrhythmic Arrhythmia Risk of injection TdPAnd Avoid in congenital long QT Levaquin, Tavanic Antibiotic Bacterial infection Risk of oral, injection TdPAnd Avoid in congenital long QT Levomepromazin Nosinan, Nozinan, Levoprome Antipsychotic Schizophrenia Risk of oral, injection e TdPAnd Avoid (Methotrimeprazin in congenital e) (Only on Non long QT US Market) Levomethadyl Orlaam Narcotic dependence Risk of oral acetate (Removed TdPAnd Avoid from US Market) in congenital long QT Levosulpiride Lesuride, Levazeo, Enliva Antipsychotic Schizophrenia Risk of oral, injection (Only on Non US TdPAnd Avoid Market) in congenital long QT Meglumine Glucatime Antiparasitic Leishmaniasis Risk of injection antimoniate (only TdPAnd Avoid on Non US in congenital Market) long QT Serentil Antipsychotic Schizophrenia Risk of oral (Removed from TdPAnd Avoid US Market) in congenital long QT Dolophine, Symoron, Opioid agonist Narcotic dependence, Risk of oral, injection Amidone, Methadose, pain TdPAnd Avoid Physeptone, Heptadon in congenital long QT Moxifloxacin Avelox, Avalox, Avelon Antibiotic Bacterial infection Risk of oral, injection TdPAnd Avoid in congenital long QT (Only Shinbit Antiarrhythmic Arrhythmia Risk of injection on Non US TdPAnd Avoid Market) in congenital long QT

Generic Name Brand Names (Partial List) Drug Class Therapeutic Use Risk Category Route

Ondansetron Zofran, Anset, Ondemet, Antiemetic Nausea, vomiting Risk of oral, Zuplenz, Emetron, Ondavell, TdPAnd Avoid injection, Emeset, Ondisolv, Setronax in congenital suppository long QT Oxaliplatin Eloxatin Anti-cancer Cancer Risk of injection TdPAnd Avoid in congenital long QT Papaverine HCl Vasodilator, Coronary Diagnostic adjunct Risk of injection (Intra-coronary) TdPAnd Avoid in congenital long QT Pentam Antifungal Fungal infection Risk of injection, (Pneumocystis TdPAnd Avoid inhaled pneumonia) in congenital long QT Orap Antipsychotic Tourette's Disorder Risk of oral TdPAnd Avoid in congenital long QT Probucol Lorelco Antilipemic Hypercholesterolemia Risk of oral (Removed from TdPAnd Avoid US Market) in congenital long QT Pronestyl, Procan Antiarrhythmic Arrhythmia Risk of injection TdPAnd Avoid in congenital long QT Diprivan, Propoven Anesthetic, general Anesthesia Risk of injection TdPAnd Avoid in congenital long QT Quinaglute, Duraquin, Antiarrhythmic Arrhythmia Risk of oral, injection Quinact, Quinidex, Cin-Quin, TdPAnd Avoid Quinora in congenital long QT Roxithromycin Rulide, Xthrocin, Roxl-150, Antibiotic Bacterial infection Risk of oral (Only on Non US Roxo, Surlid, Rulide, Biaxsig, TdPAnd Avoid Market) Roxar, Roximycinv, in congenital Roxomycin, Rulid, Tirabicin, long QT Coroxin Sevoflurane Ultane, Sojourn Anesthetic, general Anesthesia Risk of inhaled TdPAnd Avoid in congenital long QT Betapace, Sotalex, Sotacor Antiarrhythmic Arrhythmia Risk of oral TdPAnd Avoid in congenital long QT

Generic Name Brand Names (Partial List) Drug Class Therapeutic Use Risk Category Route

Sparfloxacin Zagam Antibiotic Bacterial infection Risk of oral (Removed from TdPAnd Avoid US Market) in congenital long QT Sulpiride (Only Dogmatil, Dolmatil, Eglonyl, Antipsychotic, Schizophrenia Risk of oral, inhaled on Non US Espiride, Modal, Sulpor atypical TdPAnd Avoid Market) in congenital long QT Sultopride (Only Barnetil, Barnotil, Topral Antipsychotic, Schizophrenia Risk of oral, injection on Non US atypical TdPAnd Avoid Market) in congenital long QT Terfenadine Seldane Antihistamine Allergic rhinitis Risk of oral (Removed from TdPAnd Avoid US Market) in congenital long QT Terlipressin (Only Teripress, Glypressin, Vasoconstrictor Septic shock Risk of injection on Non US Terlipin, Remestyp, Tresil, TdPAnd Avoid Market) Teriss in congenital long QT Terodiline (Only Micturin, Mictrol Muscle relaxant Bladder spasm Risk of oral on Non US TdPAnd Avoid Market) in congenital long QT Mellaril, Novoridazine, Thioril Antipsychotic Schizophrenia Risk of oral TdPAnd Avoid in congenital long QT Vandetanib Caprelsa Anti-cancer Cancer (thyroid) Risk of oral TdPAnd Avoid in congenital long QT

Heart-rate Lowering Medications

The heart-rate lowering calcium channel blockers available in the US are: ® ® • (Cardizem LA , Tiazac ) ® ® ® • (Covera-HS , Verelan PM , Calan ) ® • verapamil and trandolapril combination (Tarka ) ® • diltiazem and enalapril combination (Teczem )

Available beta-blockers in the US

Cardioselective beta blockers (that are more likely to block beta-1 receptors rather than beta-2 receptors) include: ® • (Sectral ) ® • (Tenormin and Tenoretic®) ® ® • Betaxolol (Kerlone , Betoptic ) ® • Bisoprolol (Zebeta and Ziac®) ® • (Brevibloc ) ® • Nebivolol (Bystolic ) ® ® • (Lopressor , Lopressor HCT®, Toprol-XL , Dutoprol®)

Beta blockers with intrinsic sympathomimetic activity (ISA) include: ® • Acebutolol (Sectral ) ® • (Ocupress ) ® • (Levatol ) ® • (Visken ).

Beta blockers that also block alpha blockers include: ® ® • Carvedilol (Coreg , Coreg CR ) ® • Labetalol (Trandate ).

Beta blockers that are non-selective, do not have ISA, and do not block alpha receptors include: ® • Levobunolol (Betagan ) ® • Metipranolol (OptiPranolol ) ® ® • (Corgard , Corzide ) ® ® • (Inderal , Inderal LA, Inderide®, Inderide LA®, InnoPran XL ) ® ® • Sotalol (Betapace , Sorine ) ® ® ® ® • Timolol (Betimol , Blocadren , Timolide®, Istalol , Timoptic ).

(Medications in bold are fixed dose combinations with a diuretic) Preparations in the US: • Digoxin ® • Cardoxin ® • Digitek ® • Lanoxicaps ® • Lanoxin

Other Heart Rate Lowering Medications: ® • (Adenocard IV) ® • Donepezil (Aricept ) ® • Clonidine (Catapres, Catapres-TTS, Clorpres )

• Ivabradine (Corlanor®)