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(12) United States Patent (10) Patent No.: US 9,663,587 B2 Hsieh Et Al

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(12) United States Patent (10) Patent No.: US 9,663,587 B2 Hsieh Et Al USOO9663587B2 (12) United States Patent (10) Patent No.: US 9,663,587 B2 Hsieh et al. (45) Date of Patent: May 30, 2017 (54) IL-17 BINDING PROTEINS 4,753,894 A 6, 1988 Frankel et al. 4,816,397 A 3, 1989 BOSS et al. 4,816,567 A 3/1989 Cabilly et al. (71) Applicant: AbbVie Inc., North Chicago, IL (US) 4,880,078 A 11/1989 Inoune et al. 4,943,533 A 7, 1990 Mendelsohn et al. (72) Inventors: Chung-Ming Hsieh, Newton, MA 4.946,778 A 8, 1990 Ladner et al. (US); Margaret Hugunin, North 4,980,286 A 12/1990 Morgan et al. Grafton, MA (US); Anwar Murtaza, 5,006,309 A 4, 1991 Khali1 et al. 5,063,081 A 11/1991 Cozzette et al. Westborough, MA (US); Bradford L. 5,089,424 A 2f1992 Khali1 et al. McRae, Northborough, MA (US); 5,128,326 A 7, 1992 Balazs et al. Yuliya Kutskova, Northborough, MA 5,135,875 A 8, 1992 Meucci et al. (US); John E. Memmott, Framingham, 5,223,409 A 6/1993 Ladner et al. MA (US); Jennifer M. 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Clin. 51: A 6LX 39/395 (2006.01) 19-26 (1993). A61 K 39/00 (2006.01) Jovanovic et al., “IL-17 stimulates the production and expression of proinflammatory cytokines, IL-13 and TNA-a, by human (52) U.S. Cl. macrophages,” J. Immunol. 160: 3513-3521 (1998). CPC ........ C07K 16/468 (2013.01); A61K 39/3955 Jungbluth et al., “A monoclonal antibody recognizing human can (2013.01); C07K 16/241 (2013.01); C07K cers with amplification/overexpression of the human epidermal I6/244 (2013.01); A61 K 2039/505 (2013.01); growth factor receptor.” Proc. Natl. Acad. Sci. USA, 100(2): 639 A6 IK 2039/507 (2013.01); A61 K 2300/00 644 (2003). (2013.01); C07K 231.6/96 (2013.01); C07K (Continued) 2317/21 (2013.01); C07K 23.17/31 (2013.01); C07K 2317/50 (2013.01); C07K 231 7/565 Primary Examiner — Brad Duffy (2013.01); C07K 2317/64 (2013.01); C07K Assistant Examiner — Nelson B Moseley, II 2317/76 (2013.01); C07K 2317/92 (2013.01) (74) Attorney, Agent, or Firm — Sterne, Kessler, (58) Field of Classification Search Goldstein and Fox P.L.L.C. None See application file for complete search history. (57) ABSTRACT Proteins that bind IL-17 and/or IL-17F are described along (56) References Cited with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for U.S. PATENT DOCUMENTS detecting IL-17 in cells, tissues, samples, and compositions. 4,526,938 A 7, 1985 Churchill et al. 4,554,101 A 11/1985 Hopp 45 Claims, No Drawings US 9,663,587 B2 Page 2 (56) References Cited 2005.0054078 A1 3, 2005 Miller et al. 2005, 0147610 A1 7/2005 Ghayur et al. 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WO WO99.54342 10, 1999 US 9,663,587 B2 Page 3 (56) References Cited Kipriyanov et al., “Single-chain antibody streptavidin fusions: Tetrameric bifunctional scFv-complexes with biotin binding activ FOREIGN PATENT DOCUMENTS ity and enhanced affinity to antigen.” Hum. Antibod. Hybridomas, 6:93-101 (1995). WO WO9966903 12/1999 WO WOOOO9560 2, 2000 Kirkham et al., “Synovial membrane cytokine expression is pre WO WOOO34337 6, 2000 dictive of joint damage progression in rheumatoid arthritis.” Arthri WO WOOO37.504 6, 2000 tis Rheum.
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