Venous Leg Ulcers and Lymphedema
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Bilateral Lower Extremity Hyperkeratotic Plaques: a Case Report of Ichthyosis Vulgaris
Faculty & Staff Scholarship 2015 Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris Hayley Leight Zachary Zinn Omid Jalali Follow this and additional works at: https://researchrepository.wvu.edu/faculty_publications Clinical, Cosmetic and Investigational Dermatology Dovepress open access to scientific and medical research Open Access Full Text Article CASE REPORT Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris Hayley Leight Abstract: Here, we report a case of a middle-aged woman presenting with severe, long-standing, Zachary Zinn hyperkeratotic plaques of the lower extremities unrelieved by over-the-counter medications. Omid Jalali Initial history and clinical findings were suggestive of an inherited ichthyosis. Ichthyoses are genetic disorders characterized by dry scaly skin and altered skin-barrier function. A diagnosis Department of Dermatology, West Virginia University, of ichthyosis vulgaris was confirmed by histopathology. Etiology, prevalence, and treatment Morgantown, WV, USA options are discussed. Keywords: filaggrin gene, FLG, profilaggrin, keratohyalin granules, hyperkeratosis Introduction For personal use only. Inherited ichthyoses are a diverse group of genetic disorders characterized by dry, scaly skin; hyperkeratosis; and altered skin-barrier function. While these disorders of cutaneous keratinization are multifaceted and varying in etiology, disruption in the stratum corneum with generalized scaling is common to all.1–4 Although not entirely known -
Recurrent Leg Cellulitis: Pathogenesis, Tre.Atment, and Prevention
J Am Board Fam Pract: first published as 10.3122/jabfm.5.1.85 on 1 January 1992. Downloaded from Recurrent Leg Cellulitis: Pathogenesis, Tre.atment, And Prevention Roben P. Pierce, M.D., and Allen]. Daugird, M.D. Recurrent cellulitis can develop in a variety of therapy. Subsequently, she developed chronic bi settings. Recurrent febrile episodes associated lateral lower leg edema before her first hospital with arm or leg infections, sometimes described ization at our institution. as erysipelatous, have been noted for years to Upon admission, she denied fever, chills, nau occur in the setting of filarial, postoperative, or sea, vomiting, shortness of breath, or chest pain. idiopathic chronic lymphedema. I More recently, She reported bilateral tubal ligation and ovarian recurrent cellulitis has been described as a late cyst removal more than 20 years ago. Five years complication of coronary artery bypass venec ago she had a radical mastectomy for adenocarci tomy,2-8 pelvic surgery, such as vulvectomy with noma of the breast but had negative lymph nodes lymphadenectomy9 or hysterectomy with lym and underwent no further treatment. There was ph adenectomy, 10 or of pelvic irradiation after hys no history of cellulitis of the right arm after the terectomy.11,12 The cause of recurrent cellulitis mastectomy. She denied any other pelvic surgery, has not been precisely defined but appears to be leg surgery, or abdominal or pelvic irradiation. multifactorial, involving mechanical, infectious, On examination, her temperature was 37.4°C and immune-mediated factors. We present a case (99.32°F), blood pressure 144/84 mmHg, pulse 80 of a woman with recurrent cellulitis of the legs beats per minute, and respirations 24/minute. -
Skin Brief Articles
SKIN BRIEF ARTICLES Nab-paclitaxel/gemcitabine Induced Acquired Ichthyosis Adriana Lopez BAa, Joel Shugar MDb, and Mark Lebwohl MDc aColumbia University Vagelos College of Physicians and Surgeons, New York, NY bIcahn School of Medicine at Mount Sinai, Department of Otolaryngology, New York, NY cIcahn School of Medicine at Mount Sinai, Department of Dermatology, New York, NY ABSTRACT The ichthyoses are a diverse group of cutaneous disorders characterized by abnormalities in cornification. The majority of ichthyoses are inherited with childhood presentation and new onset ichthyosis in adulthood warrants further medical evaluation. Though most well recognized for its association with Hodgkin’s disease, acquired ichthyosis (AI) has been linked to a number of inflammatory, autoimmune, and endocrine processes. However, drug- induced AI is exceedingly rare and remains a poorly understood entity. Here we report a case of a male patient who developed AI while receiving nab-paclitaxel plus gemcitabine for treatment of pancreatic adenocarcinoma. months prior, the patient was first seen for INTRODUCTION recurrent, self-healing, pruritic erythematous Acquired ichythyosis (AI) is an uncommon papules. Punch biopsy was performed which non-inherited cutaneous disorder of showed an atypical cellular infiltrate of abnormal keratinization that is most scattered large CD30+ cells with clonal T-cell frequently associated with underlying receptor-β gene rearrangement. Though the malignancy. Drug induced AI is uncommon clinicopathologic diagnosis was most and has been rarely linked to consistent with lymphomatoid papulosis chemotherapeutic agents. Herein, we report (LyP), imaging was pursued to exclude the case of a man with pancreatic extracutaneous lymphoproliferative disease. adenocarcinoma who developed an CT scan incidentally detected a mass in the ichthyosiform eruption upon starting body of the pancreas and biopsy was chemotherapy with nab-paclitaxel plus concordant with pancreatic adenocarcinoma. -
Lymphatic Complaints in the Dermatology Clinic: an Osteopathic
Volume 35 JAOCDJournal Of The American Osteopathic College Of Dermatology Lymphatic Complaints in the Dermatology Clinic: An Osteopathic Approach to Management A five-minute treatment module makes lymphatic OMT a practical option in busy practices. Also in this issue: A Case of Acquired Port-Wine Stain (Fegeler Syndrome) Non-Pharmacologic Interventions in the Prevention of Pediatric Atopic Dermatitis: What the Evidence Says Inflammatory Linear Verrucous Epidermal Nevus Worsening in Pregnancy last modified on June 9, 2016 10:54 AM JOURNAL OF THE AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY Page 1 JOURNAL OF THE AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY 2015-2016 AOCD OFFICERS PRESIDENT Alpesh Desai, DO, FAOCD PRESIDENT-ELECT Karthik Krishnamurthy, DO, FAOCD FIRST VICE-PRESIDENT Daniel Ladd, DO, FAOCD SECOND VICE-PRESIDENT John P. Minni, DO, FAOCD Editor-in-Chief THIRD VICE-PRESIDENT Reagan Anderson, DO, FAOCD Karthik Krishnamurthy, DO SECRETARY-TREASURER Steven Grekin, DO, FAOCD Assistant Editor TRUSTEES Julia Layton, MFA Danica Alexander, DO, FAOCD (2015-2018) Michael Whitworth, DO, FAOCD (2013-2016) Tracy Favreau, DO, FAOCD (2013-2016) David Cleaver, DO, FAOCD (2014-2017) Amy Spizuoco, DO, FAOCD (2014-2017) Peter Saitta, DO, FAOCD (2015-2018) Immediate Past-President Rick Lin, DO, FAOCD EEC Representatives James Bernard, DO, FAOCD Michael Scott, DO, FAOCD Finance Committee Representative Donald Tillman, DO, FAOCD AOBD Representative Michael J. Scott, DO, FAOCD Executive Director Marsha A. Wise, BS AOCD • 2902 N. Baltimore St. • Kirksville, MO 63501 800-449-2623 • FAX: 660-627-2623 • www.aocd.org COPYRIGHT AND PERMISSION: Written permission must be obtained from the Journal of the American Osteopathic College of Dermatology for copying or reprinting text of more than half a page, tables or figures. -
Cytoplasmic Plaque Formation in Hemidesmosome Development Is Dependent on Soxf Transcription Factor Function
Cytoplasmic Plaque Formation in Hemidesmosome Development Is Dependent on SoxF Transcription Factor Function Shelly Oommen1, Mathias Francois2, Maiko Kawasaki1, Melanie Murrell2, Katsushige Kawasaki1, Thantrira Porntaveetus1, Sarah Ghafoor1, Neville J. Young2, Yoshimasa Okamatsu3, John McGrath4, Peter Koopman2, Paul T. Sharpe1, Atsushi Ohazama1,3* 1 Craniofacial Development and Stem Cell Biology, and Biomedical Research Centre, Dental Institute, King’s College London, London, United Kingdom, 2 Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia, 3 Department of Periodontology, Showa University Dental School, Tokyo, Japan, 4 Genetic Skin Disease Group, St John’s Institute of Dermatology, Division of Skin Sciences, King’s College London, London, United Kingdom Abstract Hemidesmosomes are composed of intricate networks of proteins, that are an essential attachment apparatus for the integrity of epithelial tissue. Disruption leads to blistering diseases such as epidermolysis bullosa. Members of the Sox gene family show dynamic and diverse expression patterns during development and mutation analyses in humans and mice provide evidence that they play a remarkable variety of roles in development and human disease. Previous studies have established that the mouse mutant ragged-opossum (Raop) expresses a dominant-negative form of the SOX18 transcription factor that interferes with the function of wild type SOX18 and of the related SOXF-subgroup proteins SOX7 and 217. Here we show that skin and oral mucosa in homozygous Raop mice display extensive detachment of epithelium from the underlying mesenchymal tissue, caused by tearing of epithelial cells just above the plasma membrane due to hemidesmosome disruption. In addition, several hemidesmosome proteins expression were found to be dysregulated in the Raop mice. -
Venous Thromboembolism (VTE) Measure Set
Venous Thromboembolism (VTE) Measure Set Kathy Wonderly RN, MSEd, CPHQ Consultant Developed: June, 2012 Most recent update: December 2014 Major philosophy change The Center for Medicare and Medicaid (CMS) is moving away from collecting data on the process of care and focusing more on the outcomes of the care provided. Starting in January 2015, CMS will have five indicators required and one may be voluntarily submitted if your facility wished. Depending on the reporting option that your facility chooses, all 6 measures may be required for The Joint Commission’s Accreditation. Objectives To identify the value of starting VTE prophylaxis on the day of or the first day after admission or surgery end date. To list the 3 of the 4 elements included on the written warfarin discharge instructions. Prevention is the Goal To prevent such complications, the best approach is to assess each patient for VTE risk and administer primary prophylaxis to reduce the chance for developing either a DVT or PE. Introduction Hospitalized patients at high risk for VTE may develop asymptomatic deep vein thrombosis (DVT) or pulmonary embolism which may cause an unexpected death before the diagnosis is even suspected. As with the other measure sets, patients ordered “Comfort Measures only” are excluded from these requirements. The Desired Patient Outcome It is estimated that there are more than 600,000 to 1 million patients who suffer a VTE annually and approximately 50% of these are health care acquired. The goal of the CMS Partnership for Patients program is to reduce the occurrence of these HA events by 40%. -
Association Between Hemorrhoids and Lower Extremity Chronic Venous Insufficiency
Open Access Original Article DOI: 10.7759/cureus.4502 Association Between Hemorrhoids and Lower Extremity Chronic Venous Insufficiency Ugur Ekici 1 , Abdulcabbar Kartal 2 , Murat F. Ferhatoglu 2 1. General Surgery, Istanbul Gelişim University, Istanbul, TUR 2. General Surgery, Okan University Medical Faculty, Istanbul, TUR Corresponding author: Abdulcabbar Kartal, [email protected] Disclosures can be found in Additional Information at the end of the article Abstract Aim The aim of the present study was to evaluate the incidence of varicose veins among patients with hemorrhoidal disease and to compare its incidence reported in various community-based studies. Method The study group comprised of 100 patients who underwent surgery for symptomatic internal or external hemorrhoids; the control group consisted of 100 volunteers who received no prior therapy for hemorrhoidal disease and lacked any symptoms or findings suggestive of this condition. Subjects in both the groups were inquired with respect to their demographic data and risk factors. Both groups were asked to stand for two minutes before performing leg examinations while still in the standing position. The findings were recorded for both the groups. Varicose veins were classified according to the clinical appearance section of the Clinical, Etiologic, Anatomic, and Pathophysiologic (CEAP) classification that was developed by the 1994 American Venous Forum. Results There was no significant difference between the two groups with respect to age and body mass index (BMI). Significant relationships were identified between the groups with respect to the incidence of varicose veins and chronic constipation. The incidence of C1 and C2 varicose veins observed in the study group was higher than that observed in the control group. -
Compression Therapy for Venous Disease
Compression therapy for venous disease Mauro Vicaretti, Senior Lecturer, Vascular and Endovascular Surgery, Sydney Medical School, University of Sydney Summary n active or healed venous leg ulcers n lymphoedema Compression therapy, by bandaging or stockings, n prevention of deep vein thrombosis and oedema on is routine for thromboprophylaxis and for long-haul flights (more than four hours). chronic venous disease and its complications, Assessing the patient including deep venous thrombosis. The degree Before compression therapy is commenced, thorough vascular of compression is dependent on the condition assessment to exclude significant peripheral arterial disease being treated and underlying patient factors. It is essential. If pedal pulses are weakened or absent, an ankle- is important that a thorough clinical vascular brachial pressure index should be calculated. Divide the ankle examination with or without non-invasive systolic pressure of the dorsalis pedis or posterior tibial artery vascular investigations be performed to (the greater value taken as the ankle pressure) by the brachial rule out significant arterial disease that may systolic pressure (Figs. 1A–C). contraindicate the use of compression therapy. If the patient has arteriosclerosis or diabetes, it is imperative that a great toe pressure index (photoplethysmography) also Key words: chronic venous disease, compression, deep vein be performed. This is measured using a photoelectric cell thrombosis, leg ulcer. that consists of a light emitting diode and a photosensor that (Aust Prescr 2010;33:186–90) transduces changes in dermal arterial flow. A toe cuff is inflated then deflated (Fig. 1D). A waveform appears when the toe Introduction systolic pressure is reached. This pressure is divided by the Compression therapy has been used to treat chronic venous brachial pressure to give the toe brachial pressure index. -
Compression Stockings and Garments Policy
Manual: IU Health Plans Department: Utilization Management Policy # UMDET014.1 Effective Date: 08/27/2020 Supersedes Policy # UMDET014.0/or Last update or issue date: 08/23/2019 Page(s) Including attachments: 8 Medicare Advantage X Commercial Compression Stockings and Garments Policy I. Purpose Indiana University Health Plans (IU Health Plans) considers clinical indications when making a medical necessity determination for Compression Stockings and Garments. II. Scope All Utilization Management (UM) staff conducting physical and behavioral health UM review. III. Exceptions A. Gradient Compression Garments/Stockings for a member are not covered for any of the following: 1. Any over-the-counter garment/elastic stocking or compression bandage roll, even if prescribed by a provider. 2. Any garment/stocking that is supplied without a written physician’s order. 3. Gradient compression garments/stockings are not covered and not considered medically necessary for one of the following conditions with or without a written physician’s order: a. Osteoarthrosis b. Fibromitosis c. Chronic airway obstruction d. Carpal tunnel syndrome e. Urine retention f. Cellulitis g. Neurogenic bladder h. Paralysis agitans i. Sprained and or strained joints or ligaments j. Tendinitis k. Sleep apnea l. Hammer toe m. Lupus Erythematous n. Hyperlipidemia o. Dermatitis (other than stasis dermatitis from venous insufficiency) p. Asthma q. Esophageal reflux r. Cystocele s. Osteomyelitis t. Backache u. Chest pain v. Spider veins Note: Gradient Compression Garments are limited to four pairs per benefit period. IV. Definitions None V. Policy Statements A. IU Health Plans considers Compression Stockings and Garments medically necessary for the following indications: 1. Gradient Compression Garments/Stockings are covered when all of the following criteria are met: a. -
Original Article
Original Article Is chronic venous ulcer curable? A sample survey of a plastic surgeon V. Alamelu Department of Plastic, Reconstructive and Faciomaxillary Surgery, Madras Medical College and Govt General Hospital, Chennai - 600 003; Sri Jayam Hospital, West Tambaram, Chennai - 600 045; K.J. Hospital and Research Foundation, Poonamallee High Road, Chennai - 600 084, India Address for correspondence: Dr. V. Alamelu, 23, Ramakrishnan Street, West Tambaram, Chennai-600 045, India. E-mail: [email protected] ABSTRACT Introduction: Venous ulcers of lower limbs are often chronic and non-healing, many a time neglected by patients and their treating physicians as these ulcers mostly do not lead to amputation as in gangrenous arterial ulcer and also cost much to complete the course of treatment and prevention of recurrence. Materials and Methods: One hundred and twenty two lower limb venous ulcers came up for treatment between May 2006 and April 2009. Only twenty nine cases completed the treatment. The main tool of investigation was the non invasive Duplex scan venography. Biopsy of the ulcer was done for staging the disease. Patients’ choice of treatment was always conservative and as out-patient instead of hospitalisation and surgery, which required a lot of motivation by the treating unit. Results: Out of twenty nine cases, ten cases were treated conservatively and seven (24.13%) healed well. Remaining nineteen cases were given surgical modality in which fifteen cases (51.74%) were successful. Only seven cases (24.13%) failed to heal. Compression stockings were advised to control oedema, varices and pain. Foot care, regular exercises and follow-up were stressed effectively. -
Compression Stockings for Preventing the Postthrombotic Syndrome In
CLINICAL RESEARCH STUDY Compression Stockings for Preventing the Postthrombotic Syndrome in Patients with Deep Vein Thrombosis Christopher Friis Berntsen, MD,a,b Annette Kristiansen, MD,a,b Elie A. Akl, MD, MPH, PhD,c Per Morten Sandset, MD, PhD,d,e Eva-Marie Jacobsen, MD, PhD,d,e Gordon Guyatt, MD, MSc,f Per Olav Vandvik, MD, PhDa,b aDepartment of Internal Medicine, Sykehuset Innlandet Hospital Trust, Gjøvik, Norway; bInstitute of Health and Society, Faculty of Medicine, University of Oslo, Norway; cDepartment of Internal Medicine, American University of Beirut, Lebanon; dDepartment of Haematology, Oslo University Hospital, Norway; eInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; fDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. ABSTRACT OBJECTIVE: We conducted a systematic review and meta-analysis to address benefits and harms of using elastic compression stockings after lower-extremity deep vein thrombosis. METHODS: We searched 7 electronic databases through January 15, 2015, including randomized controlled trials (RCTs)/quasi-randomized trials reporting on elastic compression stocking efficacy on postthrombotic syndrome incidence, recurrent venous thromboembolism, mortality, and acute pain after deep vein thrombosis. Two reviewers independently screened records, extracted data, assessed risk of bias, and assessed confidence in effect estimates using Grading of Recommendations Assessment, Development, and Evaluation methodology. We applied random-effects meta-analysis models. RESULTS: We included 5 RCTs (n ¼ 1418) reporting on postthrombotic syndrome. The hazard ratio (HR) for postthrombotic syndrome with elastic compression stockings was 0.69 (95% confidence interval [CI], 0.47-1.02). We have very low confidence in this estimate due to heterogeneity and inclusion of unblinded studies at high risk of bias. -
Venous Ulcers October 1, 2020
Leading the way. The Guide Wire NEWSLETTER • JULY 2020 VENOUS ULCERS weight of the blood presses distally, interstitial tissue spaces produces What is a venous ulcer? and the highest pressures generated a brawny, brownish pigmentation Venous ulcers are a consequence by this mechanism are expressed at often associated with venous of venous hypertension, usually the level of the ankle and foot. ulcers. This is due to haemosiderin caused by chronic deep or deposition caused by the breakdown “The second mechanism of venous 1 superficial venous insufficiency1. of the red blood cells , and is hypertension is dynamic. The predominantly seen in the medial Until recently, it was believed that anatomic angulation of superficial lower third of the calf. Pigmentation venous ulceration was primarily to deep perforating veins and their may be followed by an itching, due to deep venous insufficiency contained valves normally prevent weeping dermatitis, in turn, possibly following valve failure, (either compartmental pressure from being progressing to ulceration2. Ulceration primary valvular failure, or as a transmitted to subcutaneous tissue may be either spontaneous, or as a consequence of deep venous and skin. Failure of this mechanism result of minor trauma. Although the thrombosis causing damage to the allows intra-compartmental pathophysiology of the ulceration venous valve), or as a result of failure forces to be transmitted directly to is not clear, it appears to be related unsupported subcutaneous veins of the calf muscle pump. However, to an inflammatory reaction in the and dermal capillaries. There, the recent studies have suggested that tissue, fibrin cuffing and eventual effective vessels elongate, dilate 3 up to 57% of venous ulcers are due lipodermatosclerosis .