Current IBiS and IGP Course Offerings

Instructor Course # Title Type QUARTER Description Course Structure and function of cells and their organelles. Morphological, molecular, and physiological approaches to IGP 405 Cell Biology CORE - Cell Biology Mitchell / Kosak Winter solving cell-biological problems.

Structure and function, taxonomy and replication of infectious agents. Host-parasite interactions and microbial IGP 442 Microbiology Core - Cell Biology Satchell Spring diseases. Prerequisites: IGP 405, IGP 410, and IGP 401 or equivalent.

Biology of cell organelles including translocation of proteins through membranes, protein secretion, organelle IBIS 406 Cell Biology CORE - Cell Biology Horvath Spring inheritance during mitosis, membrane trafficking etc.

Molecular Biology & CORE - Molecular Topics in molecular biology and the mechanisms of gene and cellular regulation. Prerequisites: Past or simultaneous IGP 410 Klumpp Fall Genetics Biology enrollment in IGP 401 or equivalent.

This course introduces regulatory pathways and molecular themes employed in signal transduction and their Signal Transduction and CORE - Molecular IGP 426 Watterson Winter modulation by pharmacological agents. The molecular basis of diverse diseases and existing therapies for them Molecular Pharmacology Biology engage the various pathways that will be covered in the course.

Receptors and Signaling CORE - Molecular Integrated discussion of different superfamilies of signaling receptors and their effectors. Pathways discussed IGP 435 Stern, Kiyokawa Spring Mechanisms Biology include G-protein linked, growth factors and cytokines, nuclear receptors and transcription factors.

CORE - Molecular Mechanisms of genome replication, control of gene expression, and protein functions are analyzed in RNA and DNA IGP 475 Virology Longnecker Spring Biology viruses.

Genome and gene structure and organization; transcription and its control, aspects of signaling and developmental Eukaryotic Molecular CORE - Molecular IBIS 402 Morimoto Fall control of gene expression; RNA processing, translation and their regulation; DNA replication and its control; Biology Biology molecular analysis of disease; applications of molecular biology in biotechnology.

Core - Systems-level An integrated view of contemporary immunology: antigens, antibodies, humoral and cell-mediated immune IGP 440 Immunology Fang Winter Biology responses, cellular interactions, and regulation of immune responses.

Basic aspects of the neoplastic phenotype, including morphologic, biochemical, genetic, cytogenetic, and other Core - Systems-level IGP 450 Tumor Cell Biology Cheng, C. Spring features; regulation of cell proliferation and differentiation; basic concepts in molecular mechanisms of chemical, Biology viral, and radiation carcinogenesis; solid tumor growth, progression, and metastasis; tumor immunology. The structural and thermodynamic basis by which protein- protein or protein-nucleic acid interactions mediate signal Structural Basis of Signal Core - Systems-level IGP 466 Freymann Spring transduction. Signaling pathways used to explore how the structural biological mechanisms underlying these Transduction Biology pathways can be experimentally determined and understood. Offered every other year, on even years

Principles and Methods of CORE - Systems-level Major concepts of embryogenesis in model animals; axis formation; cell-to-cell signaling; tissue patterning; stem IBIS 404 Carthew Winter Animal Development Biology cells. Emphasis on experimental principles.

Structures and properties of proteins, nucleic acids, and polymers, complex and simple carbohydrates, and lipids; IGP 401 Biochemistry CORE - Biophysics Prakriya / He Fall thermodynamic principles applied to biologic systems; molecules; structural correlates and functional expressions.

Selected topics in the structure and function of proteins and nucleic acids; conformational studies of GTP binding Macromolecular Structure IGP 465 CORE - Biophysics Freymann Winter proteins and kinases, enzyme mechanisms and active site ligands, structural basis of protein DNA interaction, and Function catalytic RNA. Offered every other year, on odd years Protein and nucleic acids structure; forces that determine macromolecular structure; transport and diffusion; IBIS 401 Molecular Biophysics CORE - Biophysics Mondragón Spring macromolecular assemblies; molecular machines and single molecule studies; x-ray crystallography; electron microscopy and image reconstruction; nuclear magnetic resonance; spectroscopy Current IBiS and IGP Course Offerings

General principles of drug action at the molecular level. Topics: receptor theory, drug metabolism, pharmacokinetics, Molecular Basis of Drug Core - Quantitative IGP 420 Silinsky Winter drug discovery, pharmacology of various important classes of therapeutic agents. Offered every other year, on odd Action Biology years Quantitative nature of a modern molecular understanding of basis of biology and the proper analysis of data. The CORE - Quantitative IBIS 410 Quantitative Biology Marko Fall course will have two parts, first an introduction to statistics and data analysis, and second an introduction to Biology biophysics. Genetics of prokaryotic and eukaryotic organisms; gene regulation and variation; chromosome structure and IGP 430 Genetics CORE - Genetics Urbanek Winter behavior; linkage and recombination; quantitative and population genetics; biochemical and developmental genetics; and manipulation of genes in organisms, including humans. Contemporary mass spectrometry; 2-D gels; quantitative and functional proteomics; analysis of post-translational IBIS 403 The Human Proteome CORE - Genetics Kelleher Winter modifications;, transcript profiling; strategies and technologies for genome mapping and sequencing; the human genome; polymorphisms, SNPs and genome translocations in cancer. IGP 403 Advanced Immunology ELECTIVE Bryce Fall Paper reading and discussions on selected topics in Immunology

This course is intended to introduce the basic life sciences graduate student to the thought processes involved in Introduction to Translational IGP 422 ELECTIVE Schnaper Su 12 human disease research by providing an overview of disease processes, how they are treated, and how basic Research biological science is used to develop those treatments. Key precedents and contemporary topics in drug discovery research in academia and industry. Principles of drug IGP 425 Topics in Drug Discovery ELECTIVE Watterson Fall design and action, pharmacogenetics, macromolecular target identification and characterization, bioassays and animal models of disease, study design and information management. Advanced Microbial Properties of microorganisms important in the pathogenesis genesis of infectious diseases. Emphasis on molecular IGP 433 ELECTIVE Seifert Winter Pathogenesis aspects of virulence as they relate to host-parasite interactions. This class examines, through short lectures but primarily paper discussions, the different ways in which disrupted Topics in Developmental IGP 456 ELECTIVE Kluppel Fall developmental signaling leads to birth defects. We will examine the normal and abnormal developments of multiple Biology tissue. Structure and expression of genetic information in eukaryotic organisms, emphasizing chromosome structure and Eukaryotic Molecular IGP 462 ELECTIVE Thimmappaya Fall replication, genomic organization, nuclear events involved in RNA synthesis, and transcriptional and translational Biology control mechanisms. Prerequisites: IGP 410 or equivalent.

Molecular Mechanisms of Current literature relating experimental approaches and recent discoveries in the fields of cell biology, virology, and IGP 480 ELECTIVE Green Fall Carcinogenesis molecular genetics to mechanisms of carcinogenesis. Advanced level.

Hockberger Exploration of the foundations of modern science and discussion of how these ideas impact social issues in the IGP 495 Science and Society ELECTIVE Winter R. Miller biomedical sciences (creationism, abortion, euthanasia, eugenics, cryogenics, replacement therapies, animal rights). Fundamentals of Principles and practical applications of macromolecular crystallography and NMR in contemporary structural biology IBIS 408 Macromolecular ELECTIVE Radhakrishnan F12 research. For advanced grad students; usually offered every other year Crystallography and NMR Principles and practical applications of biophysical methods in contemporary biological research, with an emphasis on understanding macromolecular structure and function. The techniques that will be covered include fluorescence Biophysical Methods for IBIS 409 ELECTIVE Radhakrishnan Fall spectroscopy (FRET and anisotropy), circular dichroism, analytical ultracentrifugation, surface plasmon resonance, Macromolecular Analysis single molecule techniques (optical tweezers and AFM), electron microscopy and mass spectrometry. For advanced grad students; usually offered every other year Cell and Structural Biology IBIS 417 ELECTIVE Klein Spring Seminar concerning the molecular biology of Alzheimer's disease. of Alzheimer’s Disease Scientific Writing & Sontheimer IBIS 455 ELECTIVE Winter Speaking Brickner

Colloquium on Integrity in IGP 494 Required - RCR training Anderson Fall Education in the responsible conduct of research and the applied ethics area of bioethics. Biomedical Research Ethics in Biological IBIS 423 RCR Klos Dehring Spring Education in the responsible conduct of research and the applied ethics area of bioethics. Research