1 CURRICULUM VITAE George Stephen Decherney, MD, MPH Born
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Toxicological Profile for Wood Creosote, Coal Tar Creosote, Coal Tar, Coal Tar Pitch, and Coal Tar Pitch Volatiles
TOXICOLOGICAL PROFILE FOR WOOD CREOSOTE, COAL TAR CREOSOTE, COAL TAR, COAL TAR PITCH, AND COAL TAR PITCH VOLATILES U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 2002 CREOSOTE ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. CREOSOTE iii UPDATE STATEMENT Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 V FOREWORD This toxicological profile is prepared in accordance with guidelines" developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The focus of the profiles is on health and toxicologic information; therefore, each toxicological profile begins with a public health statement that describes, in nontechnical language, a substance's relevant toxicological properties. -
Antibacterial and Antidiarrheal Activities of Plant Products Against Enterotoxinogenic Escherichia Coli
Toxins 2013, 5, 2009-2041; doi:10.3390/toxins5112009 OPEN ACCESS toxins ISSN 2072-6651 www.mdpi.com/journal/toxins Review Antibacterial and Antidiarrheal Activities of Plant Products against Enterotoxinogenic Escherichia coli J. Daniel Dubreuil Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal, Québec, Canada; E-Mail: [email protected]; Tel.: +1-450-773-8521 (ext.8433); Fax: +1-450-778-8108 Received: 17 September 2013; in revised form: 25 October 2013 / Accepted: 30 October 2013 / Published: 7 November 2013 Abstract: Enterotoxigenic Escherichia coli (ETEC) produces two types of enterotoxins: heat-labile (LT) and heat-stable (STa and STb). These molecules are involved in the induction of secretory diarrhea in animals including humans. This condition is currently treated using a fluid replacement therapy and antibiotics. This treatment is often not available to people in developing countries, and several die from the condition provoke by ETEC. Over the years, plants and plant extracts have been use as traditional medicine to treat various gastrointestinal ailments including diarrhea. Many of these plant products have been claimed to be active against diarrhea, however few have been extensively studied. The main objective of this review was to gather the scattered information on the antidiarrheal activities reported for various plant products on ETEC. This includes two major effects: (1) The inhibitory effect on bacterial growth or viability and (2) The interference with ETEC enterotoxins activity upon the intestinal epithelium. We will focus on plant products and extracts for which we have major indications of their biological activity against ETEC and their enterotoxins. -
Cure for Empire: the 'Conquer-Russia-Pill
Med. Hist. (2013), vol. 57(2), pp. 249–268. c The Author 2013. Published by Cambridge University Press 2013 doi:10.1017/mdh.2012.105 Cure for Empire: The ‘Conquer-Russia-Pill’, Pharmaceutical Manufacturers, and the Making of Patriotic Japanese, 1904–45 HOI-EUN KIM∗ Department of History, Texas A&M University, College Station, TX 77843-4236, USA Abstract: Seirogan, a popular anti-diarrhoeal pill, is arguably one of the most successful pharmaceutical products of modern Japan. What is less known is that the Japanese army initially developed Seirogan during the Russo-Japanese War as the ‘Conquer-Russia-Pill’, which was later marketed to the public by private manufacturers. Previous scholars have emphasised the top–down governmental method of mobilising private sectors to manipulate public opinion for the cause of external imperialist expansion and domestic stability during wartime Japan. But the matrix that the Conquer-Russia-Pill allows us to glimpse is an inverted power relation among the state, commercial sectors, and imperial citizens. While the Japanese government remained indifferent if not hostile to jingoistic pharmaceutical manufacturers who could easily disrupt international relations, pharmaceutical companies quickly recognised and exploited the opportunities that the Conquer-Russia-Pill and its symbolism provided under the banner of the empire. In turn, Japanese consumers reacted to commercial sermons carefully anchored in patriotic and militaristic discourses and images by opening their wallets. In other words, the popularity of the Conquer-Russia-Pill was a culmination of the convergence of a governmental initiative to enhance military capabilities, the commercial ingenuity of pharmaceutical manufacturers, and a consumer response to patriotic exhortations. -
'Conquer-Russia-Pill', Pharmaceutical Manufacturers, and the Making Of
Med. Hist. (2013), vol. 57(2), pp. 249–268. c The Author 2013. Published by Cambridge University Press 2013 doi:10.1017/mdh.2012.105 Cure for Empire: The ‘Conquer-Russia-Pill’, Pharmaceutical Manufacturers, and the Making of Patriotic Japanese, 1904–45 HOI-EUN KIM∗ Department of History, Texas A&M University, College Station, TX 77843-4236, USA Abstract: Seirogan, a popular anti-diarrhoeal pill, is arguably one of the most successful pharmaceutical products of modern Japan. What is less known is that the Japanese army initially developed Seirogan during the Russo-Japanese War as the ‘Conquer-Russia-Pill’, which was later marketed to the public by private manufacturers. Previous scholars have emphasised the top–down governmental method of mobilising private sectors to manipulate public opinion for the cause of external imperialist expansion and domestic stability during wartime Japan. But the matrix that the Conquer-Russia-Pill allows us to glimpse is an inverted power relation among the state, commercial sectors, and imperial citizens. While the Japanese government remained indifferent if not hostile to jingoistic pharmaceutical manufacturers who could easily disrupt international relations, pharmaceutical companies quickly recognised and exploited the opportunities that the Conquer-Russia-Pill and its symbolism provided under the banner of the empire. In turn, Japanese consumers reacted to commercial sermons carefully anchored in patriotic and militaristic discourses and images by opening their wallets. In other words, the popularity of the Conquer-Russia-Pill was a culmination of the convergence of a governmental initiative to enhance military capabilities, the commercial ingenuity of pharmaceutical manufacturers, and a consumer response to patriotic exhortations. -
National Drugs and Poisons Schedule Committee
National Drugs and Poisons Schedule Committee Record of the Reasons 38th Meeting 17-19 June 2003 Section 52D(2) of the Therapeutic Goods Act 1989 (the Act) provides the power for the NDPSC to amend the Poisons Standard or prepare a new Standard. The NDPSC takes into account relevant matters mentioned in Section 52E of the Act when making a scheduling decision. The Record of the Reasons contains the basis of scheduling decisions and other outcomes arising from the meeting. Please note that the Record of the Reasons includes extracts from the NDPSC minutes which have been edited to remove confidential information. National Drugs and Poisons Schedule Committee Record of the Reasons Meeting 38 – June 2003 i TABLE OF CONTENTS 1.8 NDPSC WORKING PARTIES ................................................................................................... 8 1.8.1 Trans-Tasman Harmonisation Working Party (Medicines) ................................................. 8 1.8.1.1.1 Definition of term "Compounded"......................................................................................8 1.8.1.1.2 Use of Term "Cosmetic"/ Hydroquinone ............................................................................9 1.8.1.1.3 Aspirin, Paracetamol and Salicylamide - Schedule 4 Entry................................................ 10 1.8.1.1.4 Aspirin - OTC ................................................................................................................. 11 1.8.1.1.5 Paracetamol.................................................................................................................... -
Toxicological Profile for Wood Creosote, Coal Tar Creosote, Coal Tar, Coal Tar Pitch, and Coal Tar Pitch Volatiles
TOXICOLOGICAL PROFILE FOR WOOD CREOSOTE, COAL TAR CREOSOTE, COAL TAR, COAL TAR PITCH, AND COAL TAR PITCH VOLATILES U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 2002 CREOSOTE ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. CREOSOTE iii UPDATE STATEMENT Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 V FOREWORD This toxicological profile is prepared in accordance with guidelines" developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The focus of the profiles is on health and toxicologic information; therefore, each toxicological profile begins with a public health statement that describes, in nontechnical language, a substance's relevant toxicological properties. -
Computational Toxinology Joseph D. Romano Submitted in Partial
Computational Toxinology Joseph D. Romano Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy under the Executive Committee of the Graduate School of Arts and Sciences COLUMBIA UNIVERSITY 2019 Oc 2019 Joseph D. Romano All rights reserved ABSTRACT Computational Toxinology Joseph D. Romano Venoms are complex mixtures of biological macromolecules and other com- pounds that are used for predatory and defensive purposes by hundreds of thousands of known species worldwide. Throughout human history, venoms and venom components have been used to treat a vast array of illnesses, causing them to be of great clinical, economic, and academic interest to the drug dis- covery and toxinology communities. In spite of major computational advances that facilitate data-driven drug discovery, most therapeutic venom effects are still discovered via tedious trial-and-error, or simply by accident. In this dis- sertation, I describe a body of work that aims to establish a new subdiscipline of translational bioinformatics, which I name “computational toxinology”. To accomplish this goal, I present three integrated components that span a wide range of informatics techniques: (1) VenomKB, (2) VenomSeq, and (3) VenomKB’s Semantic API. To provide a platform for structuring, representing, retrieving, and integrating venom data relevant to drug discovery, VenomKB provides a database-backed web application and knowledge base for compu- tational toxinology. VenomKB is structured according to a fully-featured on- tology of venoms, and provides data aggregated from many popular web re- sources. VenomSeq is a biotechnology workflow that is designed to generate new high-throughput sequencing data for incorporation into VenomKB.