2 GRAZ, Austria, 20–21 September 2012

ofstudentstatus (forconfirmation form Reduced:* Regular: Registration Registration: EUR EUR fees: 15.00* 30.00 Lecture Graz Location: Date: Hall B Internet WLAN Presenting authors are requested toattend their posters during the designated poster sessions. Prizes: internet The dimensions oftheposterboar are notpossible. projections Double The lecture room is equipped forpresentations with PowerPoint (PC format): Abstracts: oralcommunications: Short Participation is free ofcharge for APHAR Honorary Members. Authors: for Presenting Information Access: Presentation Department of Pharmacology and Toxicology Department of Pharmacognosy Contact: Department of Experimental and Clinical Pharmacology Klaus Organisers: Local Rudolf Groschner Bauer GENERAL INFORMATION INFORMATION GENERAL

There will be prizes for Austrian Pharmacologi Universitätsplatz 6,8010 Graz, Austria *Reduced registration fees areapplicable to desk. conference atthe directly fee registration pay the Please 20–21 September 2012 The prizes will be awarded at the end of the meeting. meeting. endofthe atthe awarded willbe prizes The BMC Pharmacology & Toxicology, 2012; 13 (Suppl. 1) in published are Abstracts Poster presentations: The duration of the presentation should be All presentations shall begiven in Please bring your own bring your laptopequippe Please Local organisation: Local (Institute of Pharmaceutical Sciences,Karl-Franzens University of Graz): (Institute of Pharmaceutical Sciences,Karl-Franzens University of Graz): (Medical Universityof Graz): Peter Holzer, Thomas Griesbacher Griesbacher Thomas Holzer, Peter (HS 06.02) access will be provided for free at the meeting location. location. the meeting at free for provided be will access

[email protected] Best Oral and Best Poster presentations Poster Best and Oral Best

cal Society (APHAR):

ds are:width:98cm, height:170 cm. English d for wireless internet connection. see website: http://www.aphar.at/aphar2012.html . 10minutes, followedbya 5mindiscussion.

students upon presentation ofconfirmation Uni-ReSoWi Mozartgasse Attemsgasse Universität Nearest busstop: [email protected]

Hlätgse (No.41,63) /Halbärthgasse /Geidorfgürtel (No. 39) (No. /Geidorfgürtel Hiihta2 (No.30,31) /Heirichstraß2 Gehsrß (No.41,63) /Goethestraße

.

). 3 THURSDAY, 20 September 2012

A11 A36 11:45–12:00 K.Kiemer Alexandra A85 09:45–10:00 MaedaandBernd Mayer Toma N. Glasnov, Marlen Braune Marlen N.Glasnov, Toma Binder, Christian Wadsack, Ákos Heinemann andGunther Marsche 09:30–09:45 12:15–12:30

A50 11:45–12:30 11:00–11:45 10:30–11:00 A15 09:15–09:30 09:15–10:30 09:00–09:15 Gawali,Hannes Todt,Walter A38 10:00–10:15 Dusan Bartsch, Anupam Sah, Nicolas Singewald, Martina J.Sinnegger-Brauns and Jörg Striessnig 10:15–10:30 12:00–12:15 SHORT COMMUNICATIONS 2 SHORT COMMUNICATIONS PLENARY LECTUREI &POSTERSESSION BREAK COFFEE 1 SHORT COMMUNICATIONS OFTHEMEETING OPENING see also P55 (A89) Johannes Koehbach Johannes P55 (A89) P22 (A31) see also

Naturally-occurring cyclic peptides with immunosuppressive properties

Chairs: Chairs: Chairs: Aleksandar Raškovi and pharmacodynamic proper and pharmacodynamic Astrid Schrammel dehydrogenase-2 in deficiency a genetic mouse ofascorbate model Influence of different pro- and anti-inflammatory mediators Targeting inflammatory pathologiesredress – thebalance of Pharmaceutic(Department of Sarah König, Sara Browne A TRPC3 blocker, Pyr3, prevents stent-induced remodeling arterial Tolerance to nitroglyceri Plant cyclotides as peptide templates for GPCR drug discovery drug GPCR for templates peptide as cyclotides Plant Last minute change: Anja Scharinger channels ▪ Coffee Break & Poster Session Michael Holzer Uremia alters HDL composition and cholesterol efflux capacity Peter Holzer Opening ofthe Meeting Xaver Koenig, Michael Kovar, Lena Rubi, Ág assess the drug's proarrhythmic potential The anti-addiction drug inhi A mouse model to study the C-terminal regulation of Ca Christian W.Gruber Last minute change: Poster Toursfor Poster Groups Rudolf Bauer Rudolf Bauer Klaus Groschner

(President, APHAR) APHAR) (President, , Ruth Birner-Grünberger, Tatjana Stojakovi Tatjana Birner-Grünberger, Ruth , (Innsbruck, Mannheim) , Florian Hechenblaikner, Gabriella Bo , Gerald Wölkart,Matteo, Beretta,Heik ć etal. et al. et , Nebojša Stilinovi

(Graz) (Graz)

(Graz,Chapel Hill) Hypericum perforatum (Vienna) (Vienna) (Graz) , HeinrichGerald Mächler, Höfler, C.Oliver Kappe, n through proteasomal degradation ofaldehyde Sandtner and Karlheinz Hilber , , al Biology, Saarbrücken) Ljiljana Gojkovi Ljiljana Gojkovi Ljiljana , Eric Wittchow andKlaus Groschner ties of pentobarbital, diazepam and paracetamol 1

/ 5 ć / and Momir Mikov 9 bits cardiac ion channels: astudy to /

nes KMike, Péter Lukács, Vaibhavkumar S. 13

ć ć Thursday Programmecontinueson next page -Bukarica -Bukarica L. preparations on pharmacokinetic ck, Mathias Gebhart, KaiSchönig, e Stessel, Kurt Schmidt, Nobuyo (NoviSad) ć (Vienna) , Dalia El-Gamal, Veronika (Beograd) (Beograd) V 1.3 L-type calcium (Graz)

(Graz,Erlangen)

4 THURSDAY, 20 September 2012

Francesco Ferraguti, Andrew Holmes and NicolasSingewald Andrew Holmes Ferraguti, Francesco A45 15:15–15:30 Margaret A.Smith, MarionWilebsKyle Holy, A75 15:30–15:45 Gero 16:30–17:15 Miesenböck 16:00–16:30 A1 14:45–16:00 Eva 14:00–14:45 Kostenis 12:30–14:00 14:45–15:00 andNicolasSingewald A87 15:45–16:00 Günther Sperk A42 15:00–15:15 PLENARY LECTURE III (EPHAR LECTURE) PLENARY LECTUREIII(EPHAR &POSTERSESSION BREAK COFFEE 3 SHORT COMMUNICATIONS PLENARY LECTUREII LUNCH BREAK LUNCH BREAK Chairs: Chairs: Chairs: Pharmacological Societies (with support fr Jae-Wong Yang reuptake and -stimulated efflux Dopamine transporter phosphorylation site threonine 53 regulates substrate Simone B.Sartori locus coeruleus The galanin system in depression and an (Vienna, Grand Forks) (Wayneflete Professor of Physiology, Oxford) Oxford) of Physiology, Professor (Wayneflete ▪ Coffee Break & Poster Session Janko Samardži rat forced swim test Lunch Break Antidepressant-like effects of benzodiazepine site inverse in the Ramon Tasan amygdala Neuropeptide Y modulates fear and fear extinction in distinct nuclei of the Nigel Whittle rescue resistance to fear extinction in a genetic mouse model Histone deacetylase inhibitors, glutamat medicines? (Department of Pharmaceutical Biology, Bonn) The EPHAR Lecture is sponsored by andOptogenetics for pharmacology its potential Biased seven-transmembrane receptor ligands: away to safer Poster Toursfor Poster Groups Peter Holzer Singewald Nicolas Ákos Heinemann

, Claudia Schmuckermair,, Claudia OzgeGunduz-Cinar, Markus Hauschild, , Dilip Verma,Dilip MarioMietzsch,, Regi

(Innsbruck,Darlinghurst) Berlin, , James D.Foster,AmyE.Moritz, ć and Dragan I.Obradovi , Anupam Sah,Baosheng Zhao, Inga Neumann, Rainer Landgraf

(Graz), (Graz),

(Innsbruck, Regensburg, Munich) Regensburg, (Innsbruck, (Graz) (Innsbruck), Thomas Griesbacher 2 , / Melita Šalkovi the European Federation of Federation theEuropean 6 / 10 ć Dubravka Švob Štrac om the British Pharmacological Society)

(Beograd) ki, Roxanne A. Vaughan and Harald H. Sitte / ergic drugs anddeep brain stimulation tidepressant treatment: focus on the 14 , Sathyavathi ChallaSivaKanaka, Thursday Programmecontinueson next page ne Heilbronn, Herbert Herzog and

ć -Petriši

(Graz)

ć (Innsbruck, Bethesda) (Innsbruck, (Zagreb) (Zagreb)

5 THURSDAY, 20 September 2012

Pass the main buildingsof theuniversity onyour left 18th Scientific Symposium of APHAR: The historic Orangerie iswithin walking distance ofthe meeting venue ofthe Promenade (until 8pm) or from the third courtyard ofthe Grazer Burg (entrance Hofgasse 15). You can enter the Burggarten either through the gate in the garden wall between the Burgtor and Café path diagonallytothe left (behind Zinzendorfgasse andfollow it untilyou reach the Stadtpar 19:00–21:30 17:15–18:30 17:15–18:30

RECEPTION BY THE GOVERNOR OF STYRIA OFSTYRIA GOVERNOR BYTHE RECEPTION CAREERWORKSHOP YOUNG SCIENTISTS GENERAL ASSEMBLYOFAPHAR Location: Entrance: Location: byReception the Governor of Styria Teilnahmeberechtigt sindalle ordentlichen Mitg (members of APHAR only) General Assembly of APHAR beim Vorstand schriftlich einzureichen. zugeschickt. Weitere Anträge sind mindestens sieben Tage vor dem Termin der Versammlung Mitgliederndievorläufige Tagesordnung spätes Mitglieder. Stimmberechtigt sind nur die ordentlichen Mitglieder. Gem. §9der Statuten wird den Coordination and Chair: Coordination and for young pharmacologists outside the classical academicsetting. Representatives from the Pharmaceutical Industry Sum up Open questions/Answers else...?" what "Science, Thomas Pfeifer "From academia to industry – a late-in-career transition" Maria Waldhoer "Sailing out into the perfect storm" BrownAndrew J. Keynotes: Round TableWorkshop

Lecture RoomC Lecture

Erzherzog-Johann-Allee or Hofgasse 15(Grazer Burg) BurggartenOrangerie, (Merck Group, Ausria): Ausria): Group, (Merck (NovoNordiskA/S,Copenhagen, Denmark): the bus stop),andfollow this way until you reach Erzherzog-Johann-Allee. (GlaxoSmithKline, Harlow, Essex, UK):

Maria Waldhoer Maria

(HS06.03)

(parallel session) session) (parallel

andwalkalongHalbärthga k. Cross Glacisstraße and enterthe park, taking the (Copenhagen) participants of themeeting. Participation is freeof (parallel session) tensWochen vier Generalversammlung vorder lieder, sowie Vertreter Vertreter sowie lieder, will give anoverview Friday Programme begins on next page begins onnext Programme Friday chargefor registered

sse, then turnsse, then rightinto der außerordentlichen of job opportunities

6 FRIDAY, 21 September 2012

A28 10:00–10:15 Tsikas andZeljko Tsikas Duji A17 A84 12:00–12:15 A74 09:15–09:30

A62 09:30–10:45 Location: Foyer of ABC Lecture Hall wing (meeting venue) 12:15–13:30 A19 11:45–12:15 11:00–11:45 10:30–11:00 09:00–09:15 09:00–10:30 A88 09:45–10:10 Markus Mitterhauser, Georgios Karanikas, Markus Müller and Oliver Langer A82 10:15–10:30 Palkovits, Gabriele Fuchsjäger-Mayrl, Gerd A. Kullak-Ublick 11:45–12:00 BUFFET LUNCH RECEPTION BUFFET LUNCH RECEPTION 5 SHORT COMMUNICATIONS PLENARY LECTUREIV &POSTERSESSION BREAK COFFEE PHARMACOLOGY) 4(CLINICAL SHORT COMMUNICATIONS Chairs: Chairs: Chairs: Doreen Schmidl Doreen head bloodflow nerve autoregulation onoptic oxide and endothelin ofnitric The role Martin Bauer Ivica Matak motor nerves to ACNS ofbotulinum toxin from periphery in sensory Axonal transport and Peter Matzneller Peter Characterization of colistin tissue pharmacokinetics by microdialysis (Zagreb, Würzburg) Würzburg) (Zagreb, (Vienna) Richard Schwameis Does pulmonary surfactant generally (Vienna, Poitiers) Hosted by the Mayor of the City ofGraz ofthe bytheMayor Hosted Reception Lunch Buffet Mojca Kržan rat astrocytes ▪ CoffeeBreak & Poster Session A PET microdosing study with the P-glycoprotein inhibitor tariquidar Dark Modun stress in healthy humans Plasma nitrite concentration decrease after hyperoxia-induced oxidative (Vienna) (Vienna, Seibersdorf) Robert Trondl Robert in patients suffering from advanced refractory cancer NKP-1339, a first-in-class anticancer drug (Division ofClinical Pharmacology andToxicology, Zurich) Characteristics of low affinity high capacity histamine uptake into neonatal Role ofRolehepatic transortersdrug-induced in and cholestaticliver injury Poster Toursfor Poster Groups Thomas Stockner Markus Zeitlinger Bernd Jilma

, Lidija Bach-Rojecky, Boris Filipovi Boris , LidijaBach-Rojecky, , MladenKrni , Maša Novak,, Maša Sergej Pirkmaje , Markus Zeitlinger, Cécile Philippe, Johann Stanek, Wolfgang Wadsak, ,

Petra Heffeter, Michael A. Jakupec, Walter Berger and Bernhard K. Keppler , Agnes Boltz, Semira Kaya, René Werkmeister, Reinhard Told, Stefan , William Couet,Patrice, William Gobin, Markus MarkusZeitlingerand Müller

, Sabine Strommer, Markus Zeitlinger and Robert Sauermann (Vienna), (Vienna),

ć

(Split, Hannover) ć , Jonatan Vukovi, Jonatan (Vienna), (Vienna), (Vienna), Mojca Kržan 3 / 7 Gerhard Garhöfer and Leopold Schmetterer Leopold Schmetterer and Garhöfer Gerhard Mojca Kržan Darko Modun / 11

affect antimicrobial activity? ć r andKatja Perdan-Pirkmajer / , Višnja Koki , Višnja 15 (Ljubljana) ć showing mildside effects and activity , Peter Riedererand ZdravkoLackovi

(Ljubljana) (Split) Friday Program continues on next page ć , Lea Kuko č -Modun, Dimitrios (Ljubljana)

(Vienna)

ć

7 FRIDAY, 21 September 2012

andAlexandra Koschak Free ofcharge for all registered participants 20:00–22:00 16:15–17:00 15:30–16:15 15:00–15:30 14:15–15:00 13:30–14:15 12:15–12:45 14:45–15:00 A69 A23 14:15–14:30 A68 14:30–14:45 and Rudolf Schicho APHAR FAREWELL PARTY PARTY FAREWELL APHAR &PRIZES AWARDS PLENARY LECTUREVI &POSTERSESSION BREAK COFFEE 6 SHORT COMMUNICATIONS PLENARY LECTUREV SECTION PHARMACOLOGY CLINICAL OFTHEAPHAR ASSEMBLY Chair: Chairs: Chairs: Chairs:

eietKnetAad Heribert Konzett Award AwardHans Horst Meyer PreclinicalC (Department of and Pierangelo Geppetti PharClinical (Department of Gerd Geisslinger Zinzendorfgasse Zinzendorfgasse Location: APHAR Farewell Party 6 Scholarships Travel Best Poster Presentation Prizes Best Oral Communication and ▪ CoffeeBreak & Poster Session Julia Kargl Location: of clinicalsection(members only) of theClinicalPhar Assembly End ofScientific Program Biophysical characterization ofCaV1.4 characterization Biophysical Klaus W.Schicker, Verena Burtscher congenital stationary night blindness type 2 in humans cells and reduces tumor growthina co The atypical O-1602 shows an Thomas Stockner physiological membrane environment? Which conformation does the ABC transporter P-glycoprotein adopt in the TRPA1 and pain pain and TRPA1 Lipid signaling during nociceptive processing nociceptive during signaling Lipid Poster Toursfor Poster Groups Peter Holzer Peter Holzer Ákos Heinemann Alexandra Koschak , JohannesA.Angela Stan Haybäck, Lecture HallB(HS06.02)(meeting venue) De Gustibus , Yaprak Dönmez, Zahida Parveen and Peter Chiba

(Graz) (Graz) sponsoredby AMGEN, Stadt Graz,GerotLannach

(Graz), (Graz), (Vienna, Innsbruck) (Graz), macology, Frankfurtam Main) Ana Sabo (Innsbruck) macology Section of APHAR linical Pharmacology, Florence) 4

/ Katarina , Dagmar Knoflach,Anamik 8 / sponsored by AstraZenecasponsored Austria sponsored by Pfizer Austria sponsored by 12 (Novi Sad) litis-associated co L-type calcium channel mutants causing / Č 16 č erne i titumorigenic effects in colon cancer colon effects in titumorigenic ć

, Gunther Marsche, Ákos Heinemann (Ljubljana)

Mundipharma

lon cancer modellon cancer a Singh, Thomasa Stockner

(Vienna) (Vienna)

8 POSTERS, 20–21 September 2012

P1 (A13) P7 (A5) P6 (A4) P2 (L7) P11 (A10) P8 (A6) P3 (A18) P4 (L3)  P12 (A35)  10:30–11:00: Thursday, 20 Sept, posters during to their attend requested Posters willbe ondisplay for the entire period of th P10 (A2) P5 (A3) P9 (A86) 

rdy 1Sp, 10:30–11:00: Friday, 21 Sept, 15:00–15:30: POSTER PRESENTATIONS POSTER PRESENTATIONS POSTER PRESENTATIONS Group 3: Group Group 1: Group Group 2: Group The role of CB GeraldParzmair P. Title to beannounced Karoline Pail mice lipase-deficient Role of perivascular adipose tissue in endothelial dysfunction of adipose triglyceride Rudolf Schicho Alois Lametschwandtner, Bernd Mayerand Astrid Schrammel Robert Frei (Podgorica, Novi Sad) (Podgorica, Maja Stojan Finland Remarkably lower consumption of antidepressants in Serbia in comparison with Differences in the useof medicines for pe Bojan Stanimirov betweendisease Serbia, Croatia and Sweden Saša Vukmirovi Drug Information Unit – Medical faculty of Novi Sad Ana Saboand MomirMikov Nebojša Pavlovi countries Scandinavian between Serbia and of antidiabetics the in utilisation differences Considerable Dalia El-Gamal Title to beannounced and OlgaHorvat Milijaševi Marta Rolevski Montenegro in elderly the use in medication inappropriate Potentially Vesna Mijatovi -drugs interactions: possible causes ofmethadone-related deaths Boris Milijaševi Use of ACE inhibitors in Serbia in 2010 Ana Saboand MomirMikov Ana Sabo countries: a population-based study, 2004–2008 Consumption of serum lipid-reducing drugs in Serbia compared with Scandinavian (Graz) Momir Mikov Posteron tour Posteron tour Posteron tour

ć , Zdenko Tomi andOlgaHorvat , Eva Sturm and Ákos Heinemann and Ákos Sturm , Eva 16:00–16:30: č , Sarah Winkler, Gerald Wölkart, Günter Hämmerle, Rudolf Zechner, Zechner, Rudolf Hämmerle, Günter Wölkart, Gerald Winkler, Sarah , evi (Novi Sad) ć , Berina Ku (Graz) , Michael Holzer, Martin Gauster, Veronika Binder and Gunther Marsche ć ć , IsidoraSamojlik, Stojan Petkovi 2 ć ć , Zdenko Tomi (NoviSad) receptor ligands in human eosinophil function , Ana Sabo,Zdenko, Ana Tomi , Milica P. Kusturica, Bojan Stanimirov, Maja Stojan , Milica P. Kusturica, Bojan Stanimirov, Nebojša Pavlovi Friday, 21 Sept, 10:30–11:00 Thursday, 20 Sept, 10:30–11:00 Thursday, 20 Sept, 16:00–16:30 , Karmen Stankov, Nebojša Pavlovi , IrisRed,Johanna Heinemann, ÁkosHeinemannand

ć

, Nebojša Stilinovi, Nebojša č

evi (NoviSad) (Novi Sad) (Novi Poster Groups/Tours Poster Groups/Tours Poster Groups/Tours Poster Groups/Tours (Novi Sad) ć the designated poster session andtours. ć , Gordana Boljevi , Ana Sabo, Aleksandar Raškovi e meeting (Thursday–Saturday). Presenting authors are ć , Nebojša Stilinovi

ć , Boris Milijaševi (Graz) ptic ulcer gastro-esophagealptic and reflux ć , Snežana Mugoša and Momir Mikov ć

1 2 3 4 and NikšaAjdukovi

/ / / / ć 5 6 7 8

, Milica P. Kusturica, Maja Stojan

/ / / / 9 10 11 12

ć ć / / / / (Graz) , Mikov,Momir Saša Vukmirovi 13 , Aleksandar Raškovi 14 15 16 ć and Momir Mikov

č

evi ć (NoviSad) ć ć , Zdenko Tomi , AnaSabo and continued on next page (NoviSad) ć , Boris

č evi ć , ć , ć

9 POSTERS, 19–21 November 2009

 P18 (A46) P19 (A70) P24 (A71) P14 (A41) P13 (A39) Posters continued: P25 (L2) P20 (A7) P15 (A49) P27 (A64) P17 (A61) P21 (A47)  P22 (A31) P26 (A40) P23 (L9) P16 (A60)  POSTER PRESENTATIONS POSTER PRESENTATIONS Group 4: Group Group 6: Group Group 5: Group Functional implications of K of implications Functional New structural determinantsNew structural of lo charged Péter Lukács sodium channels Aitak Farzi response to response lipopolysaccharide Bacterial peptidoglycan primes the immune system leading to increased sickness in (Novi Sad) Impaired L-typeCa Impaired Snežana Mugoša patients Adverse drug in reactions cardiac and polypharmacy Angela A.Stan Title to beannounced Vanesa Stepanov syndromemetabolic The bile acid membrane receptor TGR5: a novel pharmacological target in the Vaibhavkumar S.Gawali1, Ha Regulation ofCa Regulation (Graz) Murtaza Statins impact on epigenetics of tumor cells Hend Gafar ÁgnesK. Mike,Karlheinz Hiberand Hannes Todt Functional and physical interactions interactions andphysical Functional Alexandra Pinggera Florian Reichmann gyrus dentate the within expression NPY and c-Fos Environmental enrichment and visceral inflammation regulate stress-induced Johannes Koehbach, Markus Muttenthaler, Ca Pharmacological applications of natural peptide libraries Veronika Binder lipoprotein receptor inhibitor Uremia-induced lysinemodifi Jae-Won Yang Zdenko Tomi antibiotic dosing The role of pharmacokinetic/pharmacodynamic parameters in the optimization of (Vienna, La Jolla, Freiburg) (Vienna, Homburg) A conformational change of the domain IV Vaibhavkumar S. Gawali channel during inactivation Isabella Salzer Lena Rubi, Karlheinz Hilber and Hannes Todt Hannes and Hilber Karlheinz Rubi, Lena Xaver Koenig Posteron tour Posteron tour Posteron tour

Kulaksiz , Evelin Painsipp and Peter Holzer Peter and Painsipp Evelin , , Giri K.Chandaka andStefan Boehm , René Cervenka, Vaibhavkumar S. Gawali, Xaver Koenig, Ágnes K. Mike, ć , XuanB. Dang, Lena Rubi, Ágnes K. Mike, Péter Lukács, René Cervenka, , Ana Sabo, Momir, Svetlana Mikov, Golo (Vienna) , Wei-Quiang Chen, Helmut Kubista, Gert Lubec, Stefan Boehm and č i , Michael Holzer, Dalia El-Gamal, Sabine Dirnberger and Gunther Marsche ć , Zoran Todorovi and Friday, 21 Sept, 15:00–15:30 Thursday, 20 Sept, 16:00–16:30 Thursday, 20 Sept, 10:30–11:00 , Karmen Stankov and Momir Mikov , Ákos Heinemann, Rufina Schuligoi and Rudolf Schicho V , Evelinand PeterHolzer Painsipp

1.3 Ca , Niels Brandt, Gurjot Kaur, Ju Kaur, Gurjot Brandt, Niels , Martin Hohenegger Martin 2+

channel function in the dystrophic heart

, René Cervenka, Péter Lukács, Xaver Koenig, Lena Rubi, 2+ channels in cochlear inner hair cells cells hair inner in cochlear channels nnes Todt, Reginald E. Bittner and Karlheinzand Bittnernnes E. Todt,Reginald Hilber

V 7 channel phosphorylation 7 channel

cations transform plasma albumin into a high-density ć and Majda Šahman-Zaimovi

betweenP2Y receptors and ion channels (Vienna) (Graz) (Vienna) rsten Gründemann and Christian W. Gruber S6 segmentofthe sodiumvoltage-gated cal anaesthetic block of voltage-gated (Vienna) (Vienna) (Vienna)

tta Engeland Jörg Striessnig (Graz)

(NoviSad) č orbin Konand Boris Milijaševi

ć (Podgorica, Beograd)

(Graz) continued on next page

(Vienna) (Vienna) ć

10 10 POSTERS, 20–21 September 2012

P41 (A24)  P38 (A43) P32 (A44)  P31 (A30) P39 (A91) P30 (A8) P28 (A66) Posters continued: P40 (A16) P35 (A33) P29 (A51)  P36 (A26) P34 (A65) P33 (A58) P37 (A90) POSTER PRESENTATIONS POSTER PRESENTATIONS Group 8: Group Group 9: Group Group 7: Group Tanila Ben Haddou Radmila B.Novakovi the NO–cGMP pathway The relaxation of non-pregnant rat myometrium by resveratrol with participation of Piyush Jain Peter Riederer and Melita Šalkovi Melita and Riederer Peter Mariana Spetea, Ilona P. Berzetei-Gurske, Elena Guerrieri Elena Berzetei-Gurske, P. Ilona Spetea, Mariana a highly potent and selective Discovery andbiological ev Claudia Schmuckermair high trait affect Neurobiological correlates of successful deep brain stimulation in a mouse model of The effect of chronic fluoxetine Maja Kesi 5-HT-relatedproteins in ratswith constitutively alteredhomeostasis 5-HT Dorotea Mück-Šeler andNela Pivac way receptors ofkappaopioid reduce Activation Géza Tóth and Helmut Schmidhammer Luca Zangrandi The GABA Christine Wasinger treatment simvastatin IL-6-mediated migration of human metastatic melanoma cells is reduced by alkoxymorphinan-6-ones on Alloxan-induced diabetes altersAlloxan-induced rat commo of group Influence the 14-alkoxy and position5 the substitution in in Bihter Atil SH-SY5Y line cell neuroblastoma in the levels endogenousdolichol reduce Statins Miroslav Radenkovi Understanding subtype-selective allosteric modulation ofGABA modulation allosteric subtype-selective Understanding (Innsbruck, Rome) Ana Knezovi insulin degrading enzyme expression in a rat model of sporadic Alzheimer's disease and decicits cognitive on chelator iron multifunctional novel of a potential Therapeutic Milica Stojiljkovi Peptide YY and neuropeptide Yin regulation and NicolasSingewald Dubravka ŠvobŠtrac behavior Roshan Puthenkalam Mirnes Bajri Antiepileptic activity and subtype-selective action of flupirtine at GABA Margot Ernst Ljiljana C. Gojkovi Posteron tour Posteron tour Posteron tour

ć

, Evelyn Sieczkowski and Martin Hohenegger , Jasminka Štefulj, Gordana, Jasminka Mokrovi Štefulj, A * ć receptor receptor ć , Ahmet Hassan*,, Ahmet HerbertandHerzog Peter Holzer (Vienna) , Felicia Klinger, Ulla Schandl, Helmut Kubista andStefan Boehm , Marina Knapi , Marina andChristoph Schwarzer (Innsbruck) ć Friday, 21 Sept, 15:00–15:30 Thursday, 20 Sept, 10:30–11:00 Friday, 21 Sept, 10:30–11:00 (Beograd) (Beograd)

ć , Roberta Lattanzi,Lucia Negri, He , Christoph Minichsdorfer and Martin Hohenegger ć -Bukarica , Marko Stojanovi , Dragana D.Proti , Zdravko Varagi , Gordana Nedi (Innsbruck, Münster, München) α , Stefano Gaburro, Anupam Sah, Rainer Landgraf, Simone B.Sartori 2 subunit gene (GABRA2) is asso

ć (Beograd) (Beograd) , Jelena Osmanovi aluation ofa diphenethylamine derivative (HS665), in vitro κ ć receptor -Petriši administrationon anxiety-like behavior and expression of (Zagreb) ć , Matea Nikolac, Korona Nenadi ć ć , Pantea Mirheydari, Werner Sieghart and and Sieghart Werner Mirheydari, Pantea , ć (Innsbruck, Menlo Park, Szeged) , Radmila Jankovi, Radmila , Nebojša V. Radunovi V. , Nebojša and ć (Zagreb, Haifa, Würzburg) in vivo ć ć and Lipa n carotid artery response to adenosine -Barilar, Silvia Mandel, Moussa Youdim, s seizure activity inadose-dependent of pain and spatial learning and memory

pharmacological activities pharmacological lmut Schmidhammer andMariana Spetea

(Ljubljana) ć , MirkoTopalovi , Jayapalreddy Mallareddy, Mallareddy, Jayapalreddy , Č i č in-Šain

ciated with alcohol-related alcohol-related with ciated ć , Vladimir I. Kanjuh and (*contributed equally) (Graz) (Graz) equally) (*contributed (Zagreb) (Vienna) (Vienna)

ć Šviglin, A receptors ć and continued on next page (Vienna) N A -methyl-14- receptors

11 11 POSTERS, 20–21 September 2012

P46 (A20) P43 (A37)   P44 (A22) P53 (L8) P49 (L5) P42 (A21) Posters continued: P55 (A89) P51 (A81) P45 (A14) P50 (L6) P48(L4) P56 (A79) P47 (L1) P54 (A83)  P52 (A63) POSTER PRESENTATIONS POSTER PRESENTATIONS Group 10: Group 12: Group 11: The role of PGE Barbara S. Lang structure of dehydrogenase-2aldehyde Vascular bioactivation of nitroglycerin: reaction mechanism revealed by crystal and KlausGroschner Marion Mussbacher cells endothelial Nitricoxide signalingin adipose triglyceride lipase-deficient microvascular Georg Dorn Title to beannounced Miriam Peinhaupt Title to beannounced Justyna Kusek Sasa Frank,Bernhard A. Peskar, Regina Neubauer aldehyde dehydrogenase-2aldehyde Bioactivation of nitroglycerin is determined by the subcellular localization of Johannes Koehbach Peptidomics screening fordiscov screening the Peptidomics Restricted collision couplingof the adenosineA Laropiprant attenuatesEP Nora Kampitsch Anna Theiler Title to beannounced Schrammel and Bernd Mayer andSchrammel Bernd Katharina Jandl Title to beannounced Katja Lukan affected by metformin Activity of semicarbazide-sensitive amine oxidase in guinea-pig tissues is not Gruber Sonia Philipose, Viktória Kónya, Mirjana Lazarevi Astrid Schrammel Safina Gadeock Title to beannounced TRPC3 overexpression promotes angiot promotes TRPC3 overexpression (Graz) and Jürgen Zezula Pharmacochaperoning of the ER-retained A Furdui, Leslie B. Poole, Bernd Mayer and Karl Gruber confinement in the membrane Patrick Thurner Patrick Ákos Heinemann Bernhard Doleschal Poster tour on Poster tour on Poster tour on (Vienna,Ibadan,Galway)

, ÁkosHeinemann,, MariaWaldhoerand JuliaKargl and Simona Rajtarand Osredkar , WolfgangPlatzer,Schuligoi, Rufina ÁkosHeinemann andViktóriaKónya , Christian W. Gruber, Christian Nanoff and Michael Freissmuth , Simon Keuerleber, Ingrid Gsandtner, Christoph Gruber, Michael Freissmuth , ZoltánBálint, Gerald P. Parzmair , Rufina Schuligoi, Ákos Heinemann and RudolfSchicho , Viktória Kónya,, Viktória Heinemann Rufinaand Ákos Schuligoi , Antonius C. (Graz) 2 , Corina, Madreiter, MatteoBeretta, Gerald Wölkart,Schmidt,Kurt Astrid , Miriam Sedej and ÁkosHeinemann Sedej , Miriam (Graz) EP

(Vienna) Thursday, 20Sept, 16:00–16:30 Friday, 21 Sept, 15:00–15:30 21 Sept, Friday, Friday, 21 Sept, 10:30–11:00 21 Sept, Friday, , Sarah Winkler, Günter Hämmerle, RudolfZechner, Bernd Mayer and , Stefan Wolf,Marie-Sophie Huber, , AlfredMargaret F.Attah, O'Brien, Michael Freissmuthand Christian W. (Graz) 4 receptors in the regulation of endothelial barrier function

(Graz)

3 F. Gorren, Gustav Oberdorfer, M. Verena Wenzl, Cristina M. M. Cristina Wenzl, Verena M. Oberdorfer, Gustav Gorren, F. and TP prostanoid receptor-mediated thrombus formation

Ákos Heinemann and Rufina Schuligoi

(Ljubljana) ery of uterotonic plant peptides ensin II-induced ca

1 ć adenosine receptor , Eva Sturm, Viktória Kónyaand , Lisa M.Pasterk,

(Graz, Winston-Salem) Winston-Salem) (Graz, 2A (Graz)

receptor isdueto its agonist-induced Gerald Wölkart, GudrunAntoonsGerald Wölkart, (Graz) rdiac dysfunction , Gunther Marsche,

(Graz) (Graz) (Graz)

continued on next page (Vienna)

12 12 POSTERS, 20–21 September 2012

P63 (A72) P59 (A25) P66 (A54) P64 (A67) P70 (A78) P 57(A34) Posters continued: P69 (A76) P65 (A73) P60 (A9) P67 (A55) P58 (A29)  P68 (A56)  P62 (A77) P61 (A12)  POSTER PRESENTATIONS POSTER PRESENTATIONS Group 15: Group 13: Group 14: Katarina Katarina serous ovarian cancer Soluble osteopontin concentrations in serum and ascites of women with advanced Milica T. Atanackovi Milica T. Improving the low solubility of resveratrol Helmut Heinle, Vladimir I. Kanjuh and Ljiljana C.Gojkovi Sonja Sucic the serotonin transporter The N-terminus acts as a lever to support amphetamine-induced substrate efflux by Christian Bergmayr Pharmacological stimulation of murine and human hematopoetic stem cells Yaprak Dönmez Yaprak The NBD-NBD interface is not the sole dete Lucija Perhari as food contaminant Plasma levels of an / mixture following ingestion of low doses Oliver Kudlacek ABC transporters of the liver fluke Fasciola hepatica Polonca Ferk their relevance for histamine uptake monoamine transporter (SLC29A4)human in and 3(SLC22A3) transporter plasma ofcation membrane organic Expression Nebojša Stilinovi Protective effect of silymarin on doxorubicin-induced cardiotoxicity in rats Ali El-Kasaby transporter? How does the carboxyl terminus assist folding and ER export of the serotonin Proti Dragana D. byresveratrol vein induced The role of potassium channels in the mechanism of vasodilatation of human umbilical (Vienna, Dublin, Copenhagen, Rotterdam) Ype Elgersma, Oliver Kudlacek, Michael Freissmuth, Ulrik Gether and Harald H. Sitte Thomas Steinkellner and serotonin transporters dopamine regulatesamphetamine-induced transport in II kinase reverse Calmodulin Petra Tur in mice The influence of -melanocortin enanti Štambuk Mohammad R. Lornejad-Schäfer R. Mohammad junction protein ZO-1 and its tyrosine phosphorylation in an intestinal barrier model Acetaminophen changes paracell (Novi Sad) (Vienna, Junglinster) Strobl, Peter Selzer, WolfgangStrohmaier, Michael FreissmuthandZebedin-Brandl Eva Poster tour on Poster tour on Poster tour on

(Zagreb,Zabok) Č č i erne ć , Carina Kern,, Carina Sitte Harald H. and Michael Freissmuth , Karlo Houra,KoBradamante,, Karlo Paško Mirna , Metoda Lipnik-Štangelj, Mojca Kržan and MojcaKržan Lipnik-Štangelj, Katarina , Metoda , Florian Koban, Michael Freissmuth andSonja Sucic ć

, Gordana Koželj andLovro Stanovnik , Ana Ba , Ana , Yaprak Dönmez and Thomas Stockner , Zahida Parveen, Peter Chiba andThomas Stockner ć ć , Radmila B. Novakovi , RadmilaB. , AleksandarRaškovi Friday, 21 Sept, 10:30–11:00 21 Sept, Friday, Thursday, 21Sept, 10:30–11:00 Thursday, 21Sept,16:00–16:30 , Christian Balasz, Zarzar Kazemi, Fi ć , Therese Montgomery, Jae-WonYang, , Ljiljana C.Gojkovi

č nik, Katarina Gali Katarina nik,

, Christine Schäfer and Klaus R. Schröder ular transport activity through regulation of the tight ć , Momir Mikov,Vukmirovi , Momir Saša ć ć

, Svetlana Spremovi -Bukarica and Jelena M. Cveji-Bukarica andJelena č -Jerman and Borut Kobal and Borut -Jerman

rminant for transport in ABC transporters omers onacetaminophen-induced hepatis

umbilical vein endothelial andcells endothelial vein umbilical (Ljubljana)

(Vienna) njevoda, Tomislav Kelava andNikola lza Hussain, Thomas Bauer, Herbert ć -Bukarica

Matthias Rickhag, Sonja Sucic, ć -Radjenovi Č (Vienna) (Vienna) (Vienna) erne (Beograd, Tübingen) Tübingen) (Beograd, (Ljubljana) (Vienna)

ć (Ljubljana) ć andBoris Milijaševi (NoviSad, Beograd) ć (Linz) , Nebojša V. V. Radunovi , Nebojša continued on next page

ć

ć ,

13 13 POSTERS, 20–21 September 2012

of APHAR: Members Supporting P74 (A80) P71 (A53) Posters continued: Executive Committee: Awards &Grants: of Sponsors Symposium: of Sponsors the P73 (A32)  P76 (A57) P75 (A52) P72 (A59)

Clinical Pharmacology Pharmacology Clinical (Vienna), ZVR No.: Section Committee: SPONSORS AND SUPPORTING MEMBERS OF APHAR MEMBERS OFAPHAR ANDSUPPORTING SPONSORS POSTER PRESENTATIONS APHAR APHAR Group 16: 202359700

Kusumika Saha Felix P. Mayer 3 transporter organic cation ASP+via the offluorescent uptake Real-time (Ljubljana) Azmat Sohail Decrypting structural and functional changes in LeuTAa at atomic level employing LRET Vesna Terbuc Low affinity histamine uptake into neonatal rat astrocytes does not involve OCT (Vienna) SanthoshKannan Venkatesan transporter GltPh, homolog to mammalian glutamate transporter Deciphering structural rearrangements during transport process in the bacterial Gerhard F.Ecker,Harald H.andSitte Walter Sandtner LRET-based distancemeasurements inth Peter Chiba and Harald H. Sitte Ecker and Harald H.Sitte Kumaresan Jayaraman neurotransmitter transporters Identifying forces forces that stabilize Identifying the olig Freissmuth, Thomas Stockner, Harald H. Sitte and Walter Sandtner

Poster tour on

, SimonBulling, PeggyStolt-Bergner, Oliv , MašaNovak, Katja Perdan-Pirkmajer , Diethart Schmid, Marion Holy, Jae-Won Yang, Isabella Salzer, Stefan Boehm, , SanthoshKannan Venkatesan, Azmat Sohail, Thomas Stockner, Simon Bulling, President: Secretary Gen.: President: Further Member: Website: Further Member:

Friday, 21 Sept, 15:00–15:30 21 Sept, Friday,

, Azmat Sohail, Michael Freissmuth, Harald H. Sitteand Thomas Stockner

(Vienna) http://www.aphar.at President of the Section ofClinical Pharmacology: Peter Holzer (Graz), Bernd Jilma (Vienna), BerndJilma , Azmat Sohail,Azmat Walter, Sandtner, ThomasStockner,Gerhard F. (Vienna) (Vienna) Reiner Fischer-Colbrie (Innsbruck), Jörg Striessnig Jörg (Innsbruck) Martin Brunner Martin (Vienna)

omeric state of bacterial homologs homologs of ofbacterial state omeric e mammalian glutamate transporter EAAT3 Vice-President: Vice-President:

, Sergej Pirkmajer and Mojza Kržan (Vienna) (Vienna)

er Kudlacek,er Michael GerhardF.Ecker,

Andrea Laslop (Vienna), Markus Zeitlinger (Vienna), (Vienna) (Vienna) Treasurer:

Bernd Jilma (Vienna), BerndJilma

Michael Pohl