OVERALL STUDY RECRUITMENT UPDATE - APRIL 2018 (as of 29/04/2018) Screening lists sent Total Status Screened Recruited (previous to date month) Croydon Health Services NHS Trust Recruiting 18 (16) 125 87 (60%) 301 Chelsea and Westminster NHS Foundation Trust - West Middlesex University Hospital Recruiting 19 (13) 102 48 (47%) 153 Chelsea and Westminster Hospital NHS Foundation Trust - Chelsea and Westminster Hospital Recruiting 2 (5) 8 3 (38%) 89 Kingston Hospital NHS Foundation Trust Recruiting 16 (14) 105 59 (56%) 250 Epsom & St Helier University NHS Trust Recruiting 28 (36) 152 122 (80%) 529 St George's University Hospitals NHS Foundation Trust Recruiting 5 (8) 17 8 (47%) 63 The Hillingdon Hospitals NHS Foundation Trust Recruiting 13 (11) 67 25 (37%) 51 North West Healthcare NHS Trust - St Mark's Hospital Recruiting 1 (7) 16 7 (44%) 63 London North West Healthcare NHS Trust - Ealing Hospital Recruiting 8 (12) 37 19 (51%) 107 Imperial College Healthcare NHS Trust Recruiting 7 (0) 80 49 (61%) 83 Lewisham and Greenwich NHS Trust Recruiting 11 (17) 103 60 (58%) 102 Guys' and St Thomas' Hospital NHS Foundation Trust In Set Up King's College Hospital - Princess Royal Hospital In Set Up King's College Hospital - Denmark Hill In Set Up 517 London Total 865 (60%) 1847 Royal Surrey County Hospital NHS Foundation Trust Recruiting 61 202 Recruiting 16 58 Surrey & Sussex Healthcare NHS Trust Recruiting 56 86 University Hospital Southampton NHS Foundation Trust Recruiting 42 58 Wrightington, Wigan and Leigh NHS Foundation Trust Recruiting 54 69 Recruiting 38 50 Isle of Wight NHS Trust Recruiting 26 37 Salisbury NHS Foundation Trust Recruiting 23 34 Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust Recruiting 35 39 West Sussex Hospitals Foundation Trust - St Richards Hospital Recruiting 16 16 West Sussex Hospitals Foundation Trust - Worthing Hospital Recruiting 55 55 Medway NHS Foundation Trust Activated 0 0 East Kent Hospitals University Foundation Trust - QEQM Hospital In Set Up SIV 09/05 The Royal Sussex County Hospital In Set Up Hospitals NHS Foundation Trust In Set Up SIV 23/05 Royal Cornwall Hospital NHS Trust In Set Up Torbay and South Devon NHS Foundation Trust In Set Up Yeovil District Hospital NHS Foundation Trust In Set Up Ashford St Peters NHS trust In Set Up SIV 10/05 East Cheshire NHS Trust - Macclesfield District General Hospital In Set Up Frimley Health NHS Foundation Trust - In Set Up

Sherwood Forest Hospitals NHS Foundation Trust In Set Up

Brighton & Sussex University Hospitals NHS Trust In Set Up SIV 16/05

Walsall Healthcare NHS Trust In Set Up

The Queen Elizabeth Hospital Kings Lynn NHS Foundation Trust In Set Up

James Paget University Hospitals NHS Foundation Trust In Set Up

West Suffolk NHS Foundation Trust In Set Up

East and North Hertfordshire NHS Trust In Set Up East Sussex Healthcare NHS Trust - Eastbourne District General Hospital In Set Up Maidstone and Tunbridge Wells NHS Trust - Maidstone Hospital In Set Up North Bristol NHS Trust In Set Up Great Western Hospital NHS Trust In Set Up NHS Foundation Trust In Set Up Weston Area Health NHS Trust In Set Up Chesterfield Royal Hospital NHS Trust In Set Up Gloucestershire Royal Hospital In Set Up Non-London Total 704