<<

A213III- tissues

(formalin fixed) For research use only Specifications: • No. of cases: 30 • Tissue type: Ovary cancer tissues • No. of spots: 2 spots from each cancer case (60 spots) 10 non-neoplastic spots (10 spots) •Total spots: 70 • Corresponding normal tissues with : No • Diameter: 1. 0 mm Documents: • Product specification: layout, summary of tissue spots • H&E stained images • Detailed pathological information

Layout:

P-07-04-10T A213III- Ovary cancer tissues

(formalin fixed) For research use only Summary of tissue spots

P-07-04-11T A213III- Ovary cancer tissues

(formalin fixed) For research use only Summary of tissue spots

P-07-04-11T A213III- Ovary cancer tissues

(formalin fixed) For research use only

QC sheet_LOT#122121207131 Hematoxylin and Eosin staining

A1 A2 A3 A4

A5 A6 A7 A8

A9 A10 B1 B2

B3 B4 B5 B6

B7 B8 B9 B10

C1 C2 C3 C4

P-07-04-12T A213III- Ovary cancer tissues

(formalin fixed) For research use only

QC sheet_LOT#122121207131 Hematoxylin and Eosin staining

C5 C6 C7 C8

C9 C10 D1 D2

D3 D4 D5 D6

D7 D8 D9 D10

E1 E2 E3 E4

E5 E6 E7 E8

P-07-04-12T A213III- Ovary cancer tissues

(formalin fixed) For research use only

QC sheet_LOT#122121207131 Hematoxylin and Eosin staining

E9 E10 F1 F2

F3 F4 F5 F6

F7 F8 F9 F10

G1 G2 G3 G4

G5 G6 G7 G8

G9 G10

P-07-04-12T A213(III): Ovary cancer tissues

NoCoordinate Sex Age Key Word Histological Diagnosis with both adnexae, radical abdominal with bilateral salpingooophorectomy: : Chronic nonspecific inflammation. : Atrophy. : . , bilateral: Serous papillary cystadenocarcinoma, moderately differentiated, bilateral, with extension beyond ovarian capsule to the pelvic peritoneum and cul de sac. Serous papillary Fallopian tubes, bilateral: Free of tumor. 1 A 1,2 f 60 cystadenocarcinoma Parametrium, right: Metastatic serous . Parametrium, left : Free of tumor. Vaginal cuff: Metastatic adenocarcinoma involving cul de sac. Peritoneum, biopsy: Presence of metastatic adenocarcinoma. Omentum, omentectomy: Free of tumor. Lymph nodes, right pelvic(0/1) and left pelvic(0/1): Free of tumor in all 2 lymph nodes(0/2).

Ovary and , left, left salpingooophorectomy: Serous adenocarcinoma, poorly differentiated, of tubal serous 2 A 3,4 f 53 origin, adenocarcinoma with extension to the ovarian surface(pT2A) .

Ovary and fallopian tube, right, right salpingooophorectomy: Serous papillary Ovary: Serous papillary cystadenocarcinoma, moderately differentiated, with extraovarian spread, bilateral 3 A 5,6 f 41 cystadenocarcinoma Fallopian tube: Intraluminal spread of ovarian serous adenocarcinoma.

Uterus with right adnexa, total abdominal hysterectomy with right salpingooophorectomy: Cervix: 1. Chronic nonspecific inflammation with squamous metaplasia. 2. Metastatic ovrian adenocarcinoma involving paracervical and deep cervical stroma. Endometrium: Proliferative phase. Myometrium: Metastatic ovarian adenocarcinoma involving serosa and myometrium. Serous papillary 4 A 7,8 f 43 Ovary, right: Serous papillary adenocarcinoma, poorly differentiated, bilateral, with extraovarian spread. adenocarcinoma Fallopian tube, right: Metastatic adencoarcinoma. Parametriums, both: Metastatic adenocarcinoma. Lymph nodes, right pelvic(2/12), left pelvic(2/8) and paraaortic(2/6): in 6 out of 26 nodes. Omentum, omentectomy: Metastatic adenocarcinoma.

P-07-04-13T A213(III): Ovary cancer tissues

NoCoordinate Sex Age Key Word Histological Diagnosis Ovary and fallopian tube, right, right salpingooophorectomy: Ovary: Malignant mixed mullerian tumor composed of mixed serous and endometrioid 5 A 9,10 f 56 adenocarcinoma adenocarcinoma and heterologuous rhabdomyosarcomatous component, confined within ovarian capsule. Fallopian tube: No pathological diagnosis. Desmin: positive, Actin: negative.

Uterus with both adnexae, total abdominal hysterectomy with bilateral salpingooophorectomy: Cervix: Chronic nonspecific inflammation with squamous metaplasia. Endometrium: Atrophy. Myometrium: Serosal and deep myometrial invasion by metastatic ovarian serous adenocarcinoma. Ovaries, bilateral: Serous surface papillary adenocarcinoma, bilateral, FIGO grade II, Silverberg grade III Serous surface (8/9 scores), with spread along the peritoneal surface and extensive lymphovascular invasion. 6 B 1,2 f 63 papillary Fallopian tubes, bilateral: Free of tumor. adenocarcinoma Parametrium, right: Free of tumor. Parametrium, left: Extension of tumor with lymphatic permeation. Vaginal cuff: Free of tumor. Lyypmph node, dissection: Metastatic serous adenocarcinoma in 13 out of 33 ly ypmph nodes, in detail, right pelvic(1/8), left pelvic(0/4), paraaortic(12/21).

Uterus with both adnexae, total abdominal hysterectomy with bilateral salpingooophorectomy: Cervix: Low grade squamous intraepithelial lesion (CIN grade I). Endometrium: Proliferative phase. Myometrium: 1. Metastatic ovarian serous adenocarcinoma involving the serosa. 2. Adenomyosis. Ovary, left: Serous papillary cystadenocarcinoma, grade II, bilateral with capsular invasion and extraovarian spread. Fallopian tube, right: Metastatic serous adenocarcinoma of the ovary, involving paratubal Serous papillary and serosal surface. 7 B 3,4 f 49 cystadenocarcinoma Fallopian tube, left: Intraluminal spread of ovarian . Parametrium, both: Metastatic adenocarcinoma. Vaginal cuff: Free of tumor. Lymph node, dissection: Free of tumor in all 13 lymph nodes (0/13), in detail, right pelvic(0/4), left pelvic(0/4), paraaortic(0/5). Omentum, omentectomy: Metastatic adenocarcinoma.

P-07-04-13T A213(III): Ovary cancer tissues

NoCoordinate Sex Age Key Word Histological Diagnosis Uterus with both adnexae, total abdominal hysterectomy with bilateral salpingooophorectomy: Cervix: Erosion with acute and chronic nonspecific inflammation. Endometrium: Atrophy. Serous surface Myometrium : 1. Adenomyosis. 8 B 5,6 f 76 papillary 2. Metastatic serous adenocarcinoma involving serosa. adenocarcinoma Ovaries, bilateral: Serous surface papillary adenocarcinoma, moderately differentiated, with extraovarian spread. Fallopian tube, right: Metastatic adenocarcinoma involving fimbria. Fallopian tube, left: Free of tumor.

Ovary and fallopian tube, left, left salpingooophorectomy: Serous papillary 9 B 7,8 f 49 Ovary: Serous papillary . cystadenoma. Fallopian tube: No pathological diagnosis.

Uterus with both adnexae, total abdominal hysterectomy with bilateral salpingooophorectomy: Cervix: Chronic nonspecific inflammation with squamous metaplasia and atrophy. Endometrium: Cystic atrophy. Serous papillary 10 B 9,10 f 77 MtiNthlildiiMyometrium: No pathological diagnosis. cystadenocarcinoma Ovaries, right: Endosalpingiosis. left: Serous papillary cystadenocarcinoma, poorly differentiated, confined to the ovarian parenchyme. Fallopian tubes, bilateral: Free of tumor. Uterus including both adnexae, total abdominal hysterectomy with bilateral salpingooophorectomy: Cervix: Atrophy. Serous papillary Endometrium: Metastatic ovarian serous adenocarcinoma along endometrial lymphatics. 11 C 1,2 f 74 adenocarcinoma Myometrium: Metastatic serous adenocarcinoma involving serosa Ovaries, bilateral: Serous papillary adenocarcinoma, moderately differentiated, bilateral with extension beyond ovarian capsule and spread to peritoneal surface. Ovary, left, oophorectomy: Serous papillary adenocarcinoma, grade III, with extraovarian spread. Peritoneum: Metastatic serous adenocarcinoma. Serous papillary 12 C 3,4 f 48 Appendix: Acute serositis with congestion. adenocarcinoma Omentum: Free of tumor. Lymph node, dissection: Free of tumor in all 15 lymph nodes, in detail, right pelvic(0/5), left pelvic(0/5), paraaortic(0/5).

P-07-04-13T A213(III): Ovary cancer tissues

NoCoordinate Sex Age Key Word Histological Diagnosis Uterus with right adnexae, total abdominal hysterectomy with right salpingooophorectomy: Cervix: Chronic nonspecific inflammation Endometrium: 1. Polyp. 2. Atrophy. Serous papillary 13 C 5,6 f 53 Myometrium: 1. Metastatic serous adenocarcinoma involving the serosa. cystadenocarcinoma 2. Adenomyosis. Ovary, right: Serous papillary cystadenocarcinoma, grade III, with extensive extraovarian spread. Fallopian tube, right: Paratubal spread of adenocarcinoma. Parametrial margins, bilateral: Free of tumor. Ovary and fallopian tube, right, right salpingooophorectomy: Serous papillary 14 C 7,8 f 52 Ovary: Serous papillary cystadenocarcinoma, grade III, with extraovarian spread. cystadenocarcinoma Fallopian tube: Paratubal extension of the tumor. Uterus with both adnexae, total abdominal hysterectomy with bilateral salpingooophorectomy: Cervix: 1. Erosion. 2. Endocervical polyp. Endometrium: Atrophy . Myometrium: 1. Adenomyosis. Serous papillary 15 C 9,10 f 74 2. Metastatic ovarian adenocarcinoma involving serosa. adenocarcinoma Ovaries, bilateral: Serous papillary adenocarcinoma, high grade, with marked lymphovascular permeation, with extension beyond ovarian capsule. Fallopian tube, right: Metastatic adenocarcinoma. Fallopian tube, left: Free of tumor. Parametriums, bilateral: Free of tumor.

serous Appendix, appendectomy: 16 D 1,2 f 75 adenocarcinoma Metastatic ovarian serous adenocarcinoma involving periappendiceal flat tissue.

P-07-04-13T A213(III): Ovary cancer tissues

NoCoordinate Sex Age Key Word Histological Diagnosis Uterus with right adnexa, total abdominal hysterectomy with right salpingooophorectomy: Cervix: Chronic nonspecific inflammation. Endometrium: Cystic atrophy. Myometrium: 1. Metastatic serous adenocarcinoma of the ovary involving serosa and deep myometrium. 2. Leiomyomas, intramural. Ovary, right: 1. Serous papillary cystadenocarcinoma, grade 2, with extraovarian spread. 2. Brenner tumor. Serous papillary 3. Endosalpingiosis. 17 D 3,4 f 63 cystadenocarcinoma Fallopian tube, right: Intraluminal presence of serous adenocarcinoma. Parametriums, bilateral: Free of tumor. Omentum: Metastatic serous adenocarcinoma. Lymph node, dissection: Metastatic serous adenocarcinoma in 1 out of 52 lymph nodes (1/52), in detail, right pelvic(0/23), left pelvic(1/17), paraaortic(0/12). Note: Result of immunohistochemical stains: Cytokeratin 7: Positive in both ovarian serous adenocarcinoma and Brenner tumor Cytokeratin 20: Negative in both ovarian serous adenocarcinoma and Brenner tumor

Uterus with both adnexae , total abdominal hysterectomy with bilateral salpingooophorectomy: Cervix: Atrophy. Endometrium: 1) Atrophy. 2) Free from tumor extension. Myometrium : 1) Adenomyosis. Serous papillary 18 D 5,6 f 53 2) Free from tumor extension. cystadenocarcinoma Ovaries, bilateral: Serous papillary cystadenocarcinoma, high grade, bilateral, with extraovarian spread. Fallopian tubes, bilateral: Intraluminal spread of ovarian serous carcinoma. Regional lymph nodes: Metastatic carcinoma to 9 out of 63 lymph nodes (right pelvic(2/20), left pelvic(2/14), and paraaortic(4/18), omentum(1/11)) Omentum: Metastatic carcinoma.

P-07-04-13T A213(III): Ovary cancer tissues

NoCoordinate Sex Age Key Word Histological Diagnosis Uterus with left adnexa, total abdominal hysterectomy with left salpingooophorectomy: Cervix:Cervical intraepithelial neoplasia, grade I. Endometrium: Proliferative phase. Myometrium: 1. Metastatic ovarian serous papillary adenocarcinoma involving the serosa of the uterus. 2. Leiomyoma, intramural. 3. Adenomyosis. Serous papillary Ovary, left: Serous papillary cystadenocarcinoma, grade III, with extraovarian spread. 19 D 7,8 f 46 cystadenocarcinoma Fallopian tube, left: Free of tumor. Paraovarian tissue, right: Metastatic ovarian serous papillary adenocarcinoma. Parametrium, right: Extension of ovarian serous adenocarcinoma. Parametrium, left: Free of tumor. Lymph node, dissection: Right pelvic(1/8), left pelvic(2/11), paraaortic(3/17), right parametrial (0/7):(6/43): Tumor metastasis in 6 out of 43 nodes.

Uterus with both adnexae, total abdominal hysterectomy with bilateral salppgingooop horectomy : Cervix: 1. Erosion with squamous metaplasia. 2. Metastatic adenocarcinoma involving serosa and deep cervical stroma. Endometrium: Atrophy. Myometrium: 1. Metastatic adenocarcinoma involving the serosa and deep myometrium. 2. Leiomyoma. 3. Adenomyosis. Serous papillary 20 D 9,10 f 59 Ovaries, bilateral: Serous papillary cystadenocarcinoma, grade II, with extensive bilateral extraovarian spread cystadenocarcinoma and with extensive lymphovascular permeation. Fallopian tubes, bilateral: Metastatic adenocarcinoma. Parametrium, bilateral: Extension of tumor. Cervix resection margin: Free of tumor. Omentum: Metastatic serous papillary adenocarcinma. Lymph nodes, dissection: Right pelvic(8/8), left pelvic(2/2), mid colic(3/3), left paraaortic(1/1), paraaortic(10/10): (24/24) Tumor metastasis in all 24 nodes.

Ovary with fallopian tube and omentum, left, left salpingooophorectomy: Micropapillary serous adenocarcinoma, Micropapillary well differentiated, with extraovarian spread and extensive metastasis to omentum. 21 E 1,2 f 44 serous Fallopian tube: Tumor involvement in fimbriated end. adenocarcinoma

P-07-04-13T A213(III): Ovary cancer tissues

NoCoordinate Sex Age Key Word Histological Diagnosis Ovaries and fallopian tubes, both, bilateral salpingooophorectomy: Serous papillary cystadenocarcinoma, moderately differentiated, with extraovarian spread involving fallopian bilatera tubes and , diffusely. Right and left pelvic peritoneum, separately submitted: Involvement of carcinoma. Serous papillary 22 E 3,4 f 54 Omentum, omentectomy: Involvement of carcinoma. cystadenocarcinoma Soft tissue, labelled as diaphragm mass: Extension of carcinoma. Soft tissue, labelled as mesenteric mass: Involvement of carcinoma. Lymph nodes, dissection: (6/30) Metastatic serous adenocarcinoma in 6 out of 30 lymph nodes, in detail, right pelvic(0/8), left pelvic(3/8), paraaortic(3/14) Ovary and falloian tube, left, left salpingooophorectomy: Serous papillary 23 E 5,6 f 45 Ovary: Serous papillary cystadenocarcinoma, grade III, with extraovarian spread. cystadenocarcinoma Fallopian tube: Intraluminal spread of ovarian adenocarcinoma.

Ovary and fallopian tube, right, right salpingooophorectomy: Serous papillary adenocarcinoma, high grade (grade III) involving ovarian parenchyme and surface, tubal lumen and paratubal and serosal surface Serous papillary Omentum, omentectomy: Metastatic serous adenocarcinoma. 24 E 7,8 f 58 adidenocarcinoma Lymph node , pelvic , right , dissection (0/1): Free of tumor metastasis . Note: The primary site of tumor is unclear whether ovary, fallopian tube or double primary origin.

Ovary and fallopian tube, bilateral, bilateral salpingooophorectomy: Ovary, bilateral: Serous papillary adenocarcinoma, moderately differentiated, bilateral, with extracapsular extension. Fallopian tube, bilateral: Perisalpingheal involvement of serous adenocarcinoma. Serous papillary Peritoneum, labelled as "left gutter", biopsy: Metastatic serous adenocarcinoma. 25 E 9,10 f 62 adenocarcinoma Peritoneum, labelled as "peritoneal mass", biopsy: Metastatic serous adenocarcinoma. Soft tissue, labelled as "falciform ligament", biopsy: Metastatic serous adenocarcinoma.

Ovary and fallopian tube, right, right salpingooophorectomy: Serous papillary 26 F 1,2 f 47 Ovary: Serous papillary cystadenocarcinoma, moderately differentiated, with extraovarian spread. cystadenocarcinoma Fallopian tube: No pathological diagnosis.

Ovary and fallopian tube, left, left salpingooophorectomy: Serous papillary 27 F 3,4 f 30 Serous papillary adenocarcinoma with extraovarian spread, serosal implantatoin of adenocarcinoma fallopian tube, and prominent lymphovascular permeation.

P-07-04-13T A213(III): Ovary cancer tissues

NoCoordinate Sex Age Key Word Histological Diagnosis Serous surface Ovaries, bilateral, bilateral salpingooophorectomy: 28 F 5,6 f 65 papillary Serous surface papillary adenocarcinoma, moderately differentiated adenocarcinoma involving both ovaries and parametrial surface, with lymphatic invasion.

Serous surface Ovaries and fallopian tubes, bilateral, bilateral salpingooophorectomy: 29 F 7,8 f 51 papillary Serous surface papillary adenocarcinoma with peritoneal metastasis, and frequent lymphovascular permeation. adenocarcinoma involving both ovaries, fallopian tubes and pelvic ligaments. Ovaries and fallopian tubes, bilateral, bilateral salpingooophorectomy: Ovary, right: Malignant mixed mullerian tumor (MMMT) composed of mixed endometrioid and serous papillary Serous papillary adenocarcinoma and chondrosarcoma, with extension beyond ovarian capsule and occasional vascular invasion. 30 F 9,10 f 60 adenocarcinoma Ovary, left : Free of tumor. Fallopian tubes, right: Intravascular metastasis. left: Free of tumor.

31 G 1 f 74 non-neoplastic Non-neoplastic from C1 32 G 2 f 48 non-neoplastic Non-neoplastic from C3 33 G 3 f 53 non-neoplastic Non-neoplastic from C5 34 G 4 f 52 non-neoplastic Non-neoplastic from C7 35 G 5 f 74 non-neoplastic Non-neoplastic from C9 36 G 6 f 75 non-neoplastic Non-neoplastic from D1 37 G 7 f 63 non-neoplastic Non-neoplastic from D3 38 G 8 f 53 non-neoplastic Non-neoplastic from D5 39 G 9 f 46 non-neoplastic Non-neoplastic from D7 40 G 10 f 59 non-neoplastic Non-neoplastic from D9

P-07-04-13T