Chemical Properties Biological Description Solubility Information

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Chemical Properties Biological Description Solubility Information

Data Sheet (Cat.No.T9113) Myristicin Chemical Properties CAS No.: 607-91-0 Formula： C11H12O3 Molecular Weight： 192.21 Appearance： clear, light yellow oil Storage： 0-4℃ for short term (days to weeks), or -20℃ for long term (months). Biological Description Description Myristicin is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin may antagonize the anxiolytic effects of midazolam, increase anxiety, and affect motor movements. Myristicin can induce apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, caspase-3 activation, PARP-cleavage and DNA fragmentation. Targets(IC50) Antifection: None Bcl-2: None Caspase: None CYP17: None GABA Receptor: None IL Receptor: None NO: None PARP: None In vitro Myristicin (1-allyl-5-methoxy-3,4-methylenedioxybenzene) is an active aromatic compound found in nutmeg (the seed of Myristica fragrans), carrot, basil,cinnamon, and parsley. Myristicin has been known to have anti- cholinergic, antibacterial,and hepatoprotective effects, however, the effects of Myristicin on virus-stimulated macrophages are not fully reported. METHODS AND RESULTS:In this study, the anti-inflammatory effect of Myristicin on double-stranded RNA (dsRNA)-stimulated macrophages was examined. Myristicin did not reduce the cell viability of RAW 264.7 mouse macrophages at concentrations of up to 50 μM. Myristicin significantly inhibited the production of calcium, nitric oxide (NO),interleukin (IL)-6, IL-10, interferon inducible protein-10, monocyte chemotactic protein(MCP)-1, MCP-3, granulocyte-macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1α, MIP-1β, and leukemia inhibitory factor in dsRNA[polyinosinic- polycytidylic acid]-induced RAW 264.7 cells (P < 0.05). CONCLUSIONS:In conclusion,Myristicin has anti- inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA- stimulated macrophages via the calcium pathway. Solubility Information Solubility < 1 mg/ml refers to the product slightly soluble or insoluble Page 1 of 2 www.targetmol.com A DRUG SCREENING EXPERT Preparing Stock Solutions 1mg 5mg 10mg 1 mM 5.203 mL 26.013 mL 52.026 mL 5 mM 1.041 mL 5.203 mL 10.405 mL 10 mM 0.520 mL 2.601 mL 5.203 mL 50 mM 0.104 mL 0.520 mL 1.041 mL Please select the appropriate solvent to prepare the stock solution, according to the solubility of the product in different solvents. The storage conditions and period of the stock solution: - 80 ℃ for 6 months; - 20 ℃ for 1 month. Please use it as soon as possible. Reference 1. Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid. Molecules. 2011;16(8):7132-42. Inhibitors · Natural Compounds · Compound Libraries This product is for Research Use Only · Not for Human or Veterinary or Therapeutic Use. Tel:781-999-4286 E-mail:[email protected] Address:36 Washington Street,Wellesley Hills,MA 02481 Page 2 of 2 www.targetmol.com.

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