DOCSLIB.ORG

Big Data E Inteligencia Artificial Y HPC En Salud Y Biomedicina

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Big Data E Inteligencia Artificial Y HPC En Salud Y Biomedicina Big data e inteligencia artificial y HPC en salud y biomedicina Alfonso Valencia. Ph.D. ICREA Professor Director Life Sciences Dept. BSC Director Spanish Bioinformatics Institute INB-ISCIII ELIXIR-ES Plan TL InfoDay 21 October 19 • DATOS Datos sobre el tiempo Datos sobre Biología: Genómica, Transcriptómica, Epigenómica, Proteómica, Metabolómica, Lipidómica, …. Diez mil millones de cell phones 16 ELIXIR: European infrastructure for biological information Spanish National Bioinformatics Institute (INB) Spanish Node of ELIXIR (ELIXIR-ES) TransBioNet network of Bioinformaticians in Research Institutes of Spanish Hospitals (INB hosted) 13 • DATOS • INTELIGENCIA ARTIFICIAL 10/12/2019 Advances in AI and HPC go hand by hand Since GPUs were first used in AI (2012), computing power available to generate AI models has increased exponentially – and improvements in computing power has been key for AI progress. Petaflops/day used to train neural networks 10/12/2019 10/12/2019 BSC works on Medical Imaging ● Detecting retina pathologies ○ Trained models competitive with ophthalmologists Glaucoma Epiretinal Nevus Macular ○ With Lenovo & Hospital Vall Hebron Membrane Degeneration ● Learning from liver conditions ○ Learning about rare diseases ○ With Hospital Clinic ● Predicting and guiding in-vitro success ○ Finding the best embryo ASAP ○ With Hospital Clinic ● Supporting medical doctors on Rx review ○ Aid for Dr. in rural areas ○ With Asepeyo and ICS By Ulises Cortes and Dario Garcia UPF & BSC Predicting protein structure from the sequence is one of the fundamental problems in molecular biology. It is the key to the prediction of the consequences of mutations in human diseases and to drug design • DATOS • INTELIGENCIA ARTIFICIAL • HPC The Evolution of the Research Paradigm • Numerical Reduce expense • Avoid suffering Simulation and • Help to build knowledge where Big Data Analysis experiments are impossible or not affordable Digital Twin for Future Medicine Is this scenario possible? When? Simulations of biological systems at different levels Slide from M. Ponce de L, BSC By Mariano Vazquez, CASE - BSC ~48 h simulation time, 30 min wall time ~2500 cells Drug target Model’s readouts By Victor Guallar ICREA & BSC Large Scale Simulations AI / ML systems Exploration of Monitoring and Analysing the the parameter tailoring simulations results of the space during execution simulations time Event Recognition System Advances in AI and HPC go hand by hand Since GPUs were first used in AI (2012), computing power available to generate AI models has increased exponentially – and improvements in computing power has been key for AI progress. Petaflops/day used to train neural networks From Jordi Torres Text mining & Cognitive computing for melanoma research BSC Specialized info Watson General info BSC 16M Text mining IBM Text Bio- abstra Healthcare Analytics Knowledge cts dictionarie Catalog corpus s WATSON Cognitive computing Corpus/entities extraction Content Network of entities Analytics Bio-entities associations Inference of relationships graph Functional interpretation Translational applications myasthenia azathioprine cheilitis nephrectomy elastosis sarcoidosis aids appendectomy breast cancer LOX tyrosine kinase inhibitor lung cancer appendicitis lobectomy neurosurgery tetanus apc potency dysphagia SMAD3 leukoderma sequela SKI CTGF hypophysectom TGFB1 CAV1 y chest pain MMP1 MIF diplopia TF NOTCH1 IRF8 dilation and ITK autoimmunity pancreatic cancer IGF1 IL6 IL10 curettage splenecto ascites MST1 CD81 pancreatitis my lymphadenitis XIAP irritation anemia vulvectomy endometriosis hyperactivity lymphadenopath FAS TP53 BRCA1 hepato y toxoplasmosis teratoma gastrectomy CD55 CDKN2 uveitis ma fertility CCND vitiligo colon BRCA2 neurofibroma MSH2 cancer melanosis enucleati amaurosis CDKN2B MLH1 on LTBP2 atypicali hypercalcemia exenteration retinal PTEN ty sclerit detachmen carcinoid is t psoriasis hemosider iriti goiter s osis photocoagulati thyroidectomy amputation on In collaboration with IBM Spain Word embeddings v1 0,78 0,65 0,98 Word vectors v2 0,23 0,12 0,32 100M Word2Vec v tokens |V| 1 v v3 0,90 0,32 0,56 3 fastText v v4 0,08 0,43 0,65 2 v 4 v5 0,77 0,88 0,77 Evaluación intrínsica: cálculo similitud entre términos (sinónimos en SNOMED) 85M tokens Evaluación extrínsica: comprobar su utilidad en otras tareas PLN (neuroNER) MAPK3 H3K9 methylation cerebellar granule cells Word embeddings Word individualized Paediatric Cure (iPC) Cloud-based virtual-patient models for precision paediatric oncology Gender and other biases … Explainable Artificial Inteligence 10/12/2019.
Load more

Recommended publications
  • Semantic Web
    SEMANTIC WEB: REVOLUTIONIZING KNOWLEDGE DISCOVERY IN THE LIFE SCIENCES SEMANTIC WEB: REVOLUTIONIZING KNOWLEDGE DISCOVERY IN THE LIFE SCIENCES Edited by Christopher J. O. Baker1 and Kei-Hoi Cheung2 1Knowledge Discovery Department, Institute for Infocomm Research, Singapore, Singapore; 2Center for Medical Informatics, Yale University School of Medicine, New Haven, CT, USA Kluwer Academic Publishers Boston/Dordrecht/London Contents PART I: Database and Literature Integration Semantic web approach to database integration in the life sciences KEI-HOI CHEUNG, ANDREW K. SMITH, KEVIN Y. L. YIP, CHRISTOPHER J. O. BAKER AND MARK B. GERSTEIN Querying Semantic Web Contents: A case study LOIC ROYER, BENEDIKT LINSE, THOMAS WÄCHTER, TIM FURCH, FRANCOIS BRY, AND MICHAEL SCHROEDER Knowledge Acquisition from the Biomedical Literature LYNETTE HIRSCHMAN, WILLIAM HAYES AND ALFONSO VALENCIA PART II: Ontologies in the Life Sciences Biological Ontologies PATRICK LAMBRIX, HE TAN, VAIDA JAKONIENE, AND LENA STRÖMBÄCK Clinical Ontologies YVES LUSSIER AND OLIVIER BODENREIDER Ontology Engineering For Biological Applications vi Revolutionizing knowledge discovery in the life sciences LARISA N. SOLDATOVA AND ROSS D. KING The Evaluation of Ontologies: Toward Improved Semantic Interoperability LEO OBRST, WERNER CEUSTERS, INDERJEET MANI, STEVE RAY AND BARRY SMITH OWL for the Novice JEFF PAN PART III: Ontology Visualization Techniques for Ontology Visualization XIAOSHU WANG AND JONAS ALMEIDA On Vizualization of OWL Ontologies SERGUEI KRIVOV, FERDINANDO VILLA, RICHARD WILLIAMS, AND XINDONG WU PART IV: Ontologies in Action Applying OWL Reasoning to Genomics: A Case Study KATY WOLSTENCROFT, ROBERT STEVENS AND VOLKER HAARSLEV Can Semantic Web Technologies enable Translational Medicine? VIPUL KASHYAP, TONYA HONGSERMEIER AND SAMUEL J. ARONSON Ontology Design for Biomedical Text Mining RENÉ WITTE, THOMAS KAPPLER, AND CHRISTOPHER J.
    [Show full text]
  • Aggregation and Correlation Toolbox for Analyses of Genome Tracks Justin Jee Yale University
    University of Massachusetts eM dical School eScholarship@UMMS Program in Bioinformatics and Integrative Biology Program in Bioinformatics and Integrative Biology Publications and Presentations 4-15-2011 ACT: aggregation and correlation toolbox for analyses of genome tracks Justin Jee Yale University Joel Rozowsky Yale University Kevin Y. Yip Yale University See next page for additional authors Follow this and additional works at: http://escholarship.umassmed.edu/bioinformatics_pubs Part of the Bioinformatics Commons, Computational Biology Commons, and the Systems Biology Commons Repository Citation Jee, Justin; Rozowsky, Joel; Yip, Kevin Y.; Lochovsky, Lucas; Bjornson, Robert; Zhong, Guoneng; Zhang, Zhengdong; Fu, Yutao; Wang, Jie; Weng, Zhiping; and Gerstein, Mark B., "ACT: aggregation and correlation toolbox for analyses of genome tracks" (2011). Program in Bioinformatics and Integrative Biology Publications and Presentations. Paper 26. http://escholarship.umassmed.edu/bioinformatics_pubs/26 This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in Program in Bioinformatics and Integrative Biology Publications and Presentations by an authorized administrator of eScholarship@UMMS. For more information, please contact [email protected]. ACT: aggregation and correlation toolbox for analyses of genome tracks Authors Justin Jee, Joel Rozowsky, Kevin Y. Yip, Lucas Lochovsky, Robert Bjornson, Guoneng Zhong, Zhengdong Zhang, Yutao Fu, Jie Wang, Zhiping Weng, and Mark B. Gerstein Comments © The Author(s) 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non- Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non- commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    [Show full text]
  • Biocreative II.5 Workshop 2009 Special Session on Digital Annotations
    BioCreative II.5 Workshop 2009 Special Session on Digital Annotations The purified IRF-4 was also The main role of BRCA2 shown to be capable of binding appears to involve regulating the DNA in a PU.1-dependent manner function of RAD51 in the repair by by electrophoretic mobility shift homologous recombination . analysis. brca2 irf4 We found that cells ex- Moreover, expression of pressing Olig2, Nkx2.2, and NG2 Carma1 induces phosphorylation were enriched among virus- of Bcl10 and activation of the infected, GFP-positive (GFP+) transcription factor NF-kappaB. cells. carma1 BB I O olig2 The region of VHL medi- The Rab5 effector ating interaction with HIF-1 alpha Rabaptin-5 and its isoform C R E A T I V E overlapped with a putative Rabaptin-5delta differ in their macromolecular binding site within ability to interact with the rsmallab5 the crystal structure. GTPase Rab4. vhl Translocation RCC, bearing We show that ERBB2-dependenterbb2 atf1 TFE3 or TFEB gene fusions, are Both ATF-1 homodimers and tfe3 medulloblastoma cell invasion and ATF-1/CREB heterodimers bind to recently recognized entities for prometastatic gene expression can the CRE but not to the related which risk factors have not been be blocked using the ERBB tyrosine phorbol ester response element. identified. kinase inhibitor OSI-774. C r i t i c a l A s s e s s m e n t o f I n f o r m a t i o n E x t r a c t i o n i n B i o l o g y October 7th - 9th, 2009 www.BioCreative.org BioCreative II.5 Workshop 2009 special session | Digital Annotations Auditorium of the Spanish National
    [Show full text]
  • Tporthmm : Predicting the Substrate Class Of
    TPORTHMM : PREDICTING THE SUBSTRATE CLASS OF TRANSMEMBRANE TRANSPORT PROTEINS USING PROFILE HIDDEN MARKOV MODELS Shiva Shamloo A thesis in The Department of Computer Science Presented in Partial Fulfillment of the Requirements For the Degree of Master of Computer Science Concordia University Montréal, Québec, Canada December 2020 © Shiva Shamloo, 2020 Concordia University School of Graduate Studies This is to certify that the thesis prepared By: Shiva Shamloo Entitled: TportHMM : Predicting the substrate class of transmembrane transport proteins using profile Hidden Markov Models and submitted in partial fulfillment of the requirements for the degree of Master of Computer Science complies with the regulations of this University and meets the accepted standards with respect to originality and quality. Signed by the final examining commitee: Examiner Dr. Sabine Bergler Examiner Dr. Andrew Delong Supervisor Dr. Gregory Butler Approved Dr. Lata Narayanan, Chair Department of Computer Science and Software Engineering 20 Dean Dr. Mourad Debbabi Faculty of Engineering and Computer Science Abstract TportHMM : Predicting the substrate class of transmembrane transport proteins using profile Hidden Markov Models Shiva Shamloo Transporters make up a large proportion of proteins in a cell, and play important roles in metabolism, regulation, and signal transduction by mediating movement of compounds across membranes but they are among the least characterized proteins due to their hydropho- bic surfaces and lack of conformational stability. There is a need for tools that predict the substrates which are transported at the level of substrate class and the level of specific substrate. This work develops a predictor, TportHMM, using profile Hidden Markov Model (HMM) and Multiple Sequence Alignment (MSA).
    [Show full text]
  • MPGM: Scalable and Accurate Multiple Network Alignment
    MPGM: Scalable and Accurate Multiple Network Alignment Ehsan Kazemi1 and Matthias Grossglauser2 1Yale Institute for Network Science, Yale University 2School of Computer and Communication Sciences, EPFL Abstract Protein-protein interaction (PPI) network alignment is a canonical operation to transfer biological knowledge among species. The alignment of PPI-networks has many applica- tions, such as the prediction of protein function, detection of conserved network motifs, and the reconstruction of species’ phylogenetic relationships. A good multiple-network align- ment (MNA), by considering the data related to several species, provides a deep understand- ing of biological networks and system-level cellular processes. With the massive amounts of available PPI data and the increasing number of known PPI networks, the problem of MNA is gaining more attention in the systems-biology studies. In this paper, we introduce a new scalable and accurate algorithm, called MPGM, for aligning multiple networks. The MPGM algorithm has two main steps: (i) SEEDGENERA- TION and (ii) MULTIPLEPERCOLATION. In the first step, to generate an initial set of seed tuples, the SEEDGENERATION algorithm uses only protein sequence similarities. In the second step, to align remaining unmatched nodes, the MULTIPLEPERCOLATION algorithm uses network structures and the seed tuples generated from the first step. We show that, with respect to different evaluation criteria, MPGM outperforms the other state-of-the-art algo- rithms. In addition, we guarantee the performance of MPGM under certain classes of net- work models. We introduce a sampling-based stochastic model for generating k correlated networks. We prove that for this model if a sufficient number of seed tuples are available, the MULTIPLEPERCOLATION algorithm correctly aligns almost all the nodes.
    [Show full text]
  • You Are Cordially Invited to a Talk in the Edmond J. Safra Center for Bioinformatics Distinguished Speaker Series
    You are cordially invited to a talk in the Edmond J. Safra Center for Bioinformatics Distinguished Speaker Series. The speaker is Prof. Alfonso Valencia, Spanish National Cancer Research Centre, CNIO. Title: "A mESC epigenetics network that combines chromatin localization data and evolutionary information" Time: Wednesday, November 11 2015, at 11:00 (refreshments from 10:50) Place: Green building seminar room, ground floor, Biotechnology Department. Host: Prof. Ron Shamir, [email protected], School of Computer Science Abstract: The description of biological systems in terms of networks is by now a well- accepted paradigm. Networks offer the possibility of combining complex information and the system to analyse the properties of individual components in relation to the ones of their interaction partners. In this context, we have analysed the relations between the known components of mouse Embryonic Stem Cells (mESC) epigenome at two orthogonal levels of information, i.e., co-localization in the genome and concerted evolution (co-evolution). Public repositories contain results of ChIP-Seq experiments for more than 60 Chromatin Related Proteins (CRPs), 14 for Histone modifications, and three different types of DNA methylation, including 5-Hydroxymethylcytosine (5hmc). All this information can be summarized in a network in which the nodes are the CRPs, histone marks and DNA modifications and the arcs connect components that significantly co-localize in the genome. In this network co-localization preferences are specific of chromatin states, such as promoters and enhancers. A second network was build by connecting proteins that are part of the mESC epigenetic regulatory system and show signals of co-evolution (concerted evolution of the CRPs protein families).
    [Show full text]
  • ISCB's Initial Reaction to the New England Journal of Medicine
    MESSAGE FROM ISCB ISCB’s Initial Reaction to The New England Journal of Medicine Editorial on Data Sharing Bonnie Berger, Terry Gaasterland, Thomas Lengauer, Christine Orengo, Bruno Gaeta, Scott Markel, Alfonso Valencia* International Society for Computational Biology, Inc. (ISCB) * [email protected] The recent editorial by Drs. Longo and Drazen in The New England Journal of Medicine (NEJM) [1] has stirred up quite a bit of controversy. As Executive Officers of the International Society of Computational Biology, Inc. (ISCB), we express our deep concern about the restric- tive and potentially damaging opinions voiced in this editorial, and while ISCB works to write a detailed response, we felt it necessary to promptly address the editorial with this reaction. While some of the concerns voiced by the authors of the editorial are worth considering, large parts of the statement purport an obsolete view of hegemony over data that is neither in line with today’s spirit of open access nor furthering an atmosphere in which the potential of data can be fully realized. ISCB acknowledges that the additional comment on the editorial [2] eases some of the polemics, but unfortunately it does so without addressing some of the core issues. We still feel, however, that we need to contrast the opinion voiced in the editorial with what we consider the axioms of our scientific society, statements that lead into a fruitful future of data-driven science: • Data produced with public money should be public in benefit of the science and society • Restrictions to the use of public data hamper science and slow progress OPEN ACCESS • Open data is the best way to combat fraud and misinterpretations Citation: Berger B, Gaasterland T, Lengauer T, Orengo C, Gaeta B, Markel S, et al.
    [Show full text]
  • Keynote Speaker
    4th BSC Severo Ochoa Doctoral Symposium KEYNOTE SPEAKER Alfonso Valencia Head of Life Sciences Department, BSC Personalised Medicine as a Computational Challenge Personalized Medicine represents the adoption of Genomics and other –omics technologies to the diagnosis and treatment of diseases. PerMed is one of the more interesting and promising developments resulting from the genomic revolution. The treatment and analysis of genomic information is tremendously challenging for a number of reasons that include the diversity and heterogeneity of the data, strong dependence of the associated metadata (i.e, experimental details), very fast evolution of the methods, and the size and confidentiality of the data sets. Furthermore, the lack of a sufficiently developed conceptual framework in Molecular Biology makes the interpretation of the data extremely difficult. In parallel, the work in human diseases will require the combination of the –omics information with the description of diseases, symptoms, drugs and treatments: The use of this information, recorded in Electronic Medical Records and other associated documents, requires the development and application of Text Mining and Natural Language processing technologies. These problems have to be seen as opportunities, particularly for students and Post Docs in Bioinformatics, Engineering and Computer Sciences. During this talk, I will introduce some of the areas in which the Life Sciences Department works, from Simulation to Genome Analysis, including text mining, pointing to what I see as the most promising future areas of development. Alfonso Valencia is the founder and President of the International Society for Computational Biology and Co-Executive Director of the main journal in the field (Bioinformatics of Oxford University Press).
    [Show full text]
  • Obstacles to Studying Alternative Splicing Using Scrna-Seq
    bioRxiv preprint doi: https://doi.org/10.1101/797951; this version posted October 8, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. Obstacles to Studying Alternative Splicing Using scRNA-seq Jennifer Westoby∗1, Pavel Artemovy2, Martin Hembergz3, and Anne Ferguson-Smithx4 1Department of Genetics, University of Cambridge , Downing Street, CB2 3EH 2Department of Genetics, University of Cambridge , Downing Street, CB2 3EH 3Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA 4Department of Genetics, University of Cambridge, Downing Street, CB2 3EH October 8, 2019 ∗Electronic address: [email protected]; Corresponding author yElectronic address: [email protected]; zElectronic address: [email protected]; xElectronic address: [email protected]; 1 bioRxiv preprint doi: https://doi.org/10.1101/797951; this version posted October 8, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. Abstract Background Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched bulk RNA-seq samples. How- ever, these studies generally did not consider the impact of dropouts or isoform quantification errors, potentially confounding the results of these analyses.
    [Show full text]
  • I S C B N E W S L E T T
    ISCB NEWSLETTER FOCUS ISSUE {contents} President’s Letter 2 Member Involvement Encouraged Register for ISMB 2002 3 Registration and Tutorial Update Host ISMB 2004 or 2005 3 David Baker 4 2002 Overton Prize Recipient Overton Endowment 4 ISMB 2002 Committees 4 ISMB 2002 Opportunities 5 Sponsor and Exhibitor Benefits Best Paper Award by SGI 5 ISMB 2002 SIGs 6 New Program for 2002 ISMB Goes Down Under 7 Planning Underway for 2003 Hot Jobs! Top Companies! 8 ISMB 2002 Job Fair ISCB Board Nominations 8 Bioinformatics Pioneers 9 ISMB 2002 Keynote Speakers Invited Editorial 10 Anna Tramontano: Bioinformatics in Europe Software Recommendations11 ISCB Software Statement volume 5. issue 2. summer 2002 Community Development 12 ISCB’s Regional Affiliates Program ISCB Staff Introduction 12 Fellowship Recipients 13 Awardees at RECOMB 2002 Events and Opportunities 14 Bioinformatics events world wide INTERNATIONAL SOCIETY FOR COMPUTATIONAL BIOLOGY A NOTE FROM ISCB PRESIDENT This newsletter is packed with information on development and dissemination of bioinfor- the ISMB2002 conference. With over 200 matics. Issues arise from recommendations paper submissions and over 500 poster submis- made by the Society’s committees, Board of sions, the conference promises to be a scientific Directors, and membership at large. Important feast. On behalf of the ISCB’s Directors, staff, issues are defined as motions and are discussed EXECUTIVE COMMITTEE and membership, I would like to thank the by the Board of Directors on a bi-monthly Philip E. Bourne, Ph.D., President organizing committee, local organizing com- teleconference. Motions that pass are enacted Michael Gribskov, Ph.D., mittee, and program committee for their hard by the Executive Committee which also serves Vice President work preparing for the conference.
    [Show full text]
  • Optimization and Machine Learning Applications to Protein Sequence and Structure
    Optimization and Machine Learning Applications to Protein Sequence and Structure A DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY Kevin W. DeRonne IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF Doctor of Philosophy George Karypis January, 2013 c Kevin W. DeRonne 2013 ALL RIGHTS RESERVED Acknowledgements This thesis represents the culmination of over ten years of work. Not once over those ten years did I actually expect to be writing these words, and it is only through the stalwart, foolish, patient love and support of a great many people that I am. There are far too many names I need to list, so I can only name a few, but to the others who do not appear here: you are by no means forgotten. Professors Cavan Reilly, Ravi Janardan and Vipin Kumar: thank you for taking the time to serve on my preliminary and final examination committees. It is an honor to have people of such quality reviewing my work. Professor George Karypis: I have no idea why you put up with me for so long, but here we are. Despite my repeated attempts to force you to give up on me, you never did. The only way I can be succinct about what you have done for me is this: I have become the computer scientist I am because of you. Patrick Coleman Saunders: in death as in life, you made me a better person. Chas Kennedy, David Mulvihill, Dan O'Brien, Adam Meyer, Andrew Owen, Huzefa Rangwala, Jeff Rostis, David Seelig, Neil Shah and Nikil Wale: I hope you know that you are all like brothers to me.
    [Show full text]
  • Basel Computational Biology Conference. from Information to Simulation
    Information Extraction in Molecular Biology and Biomedicine Basel Computational Biology Conference. From Information to Simulation Basel, 18-19 March 2004 Alfonso Valencia, CNB - CSIC BC2, 2004 Alfonso Valencia CNB-CSIC Predicted networks Proteomics literature Functional BC2, 2004 Alfonso Valencia CNB-CSIC Genomics Information Extraction in Molecular Biology IE starts in biology [1] Keyword retrieval systems [2] Detection of protein names [3] Detection of protein-protein interactions [4] IE meets experiments [5] 1997 1998 1999 2000 2001 [1] Ohta et al. (1997). "Automatic construction of Knowledge Bases form Biological Papers" [2] Andrade and Valencia (1997). "Automatic annotation for biological sequences by extraction of keywords from MEDLINE abstracts" [3] Fukuda et al. (1998). "Information Extraction: Identifying Protein Names from Biological Papers" Proux et al. (1998). "Detecting Gene Symbols and Names in Biological Texts: a first step ..." [4] Blaschke et al. (1999). "Automatic Extraction of Biological Information ...: Protein-Protein Interactions" Park et al. (2001). "Incremental Parsing for Automatic Pathway Identification with Combinatorial Categorical Grammar" Proux et al. (2000). "... Information Extraction Strategy for gathering Data on Genetic Interactions" Rindflesch et al. (2000). "EDGAR: Extraction of Drugs, Genes and Relations from the Biomedical Literature" Sekimizu et al. (1998). "Identifying the Interaction between Genes and Gene Products based on frequently seen Verbs in Medline Abstracts" Thomas et al. (2000). "Automatic
    [Show full text]