DOCSLIB.ORG

Topiramate Accord Healthcare 25Mg, 50Mg, 100Mg and 200Mg Film-Coated Tablets (Topiramate)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Topiramate Accord Healthcare 25Mg, 50Mg, 100Mg and 200Mg Film-Coated Tablets (Topiramate) Package leaflet: Information for the user Topiramate Accord Healthcare 25mg, 50mg, 100mg and 200mg Film-coated Tablets (Topiramate) Read all of this leaflet carefully before you start Topiramate tablets with food, drink and alcohol taking this medicine because it contains important You can take Topiramate tablets with or without food. To information for you. prevent kidney stones whilst being treated with Topiramate • Keep this leaflet. You may need to read it again. tablets, drink plenty of fluids during the day. You should • If you have any further questions, ask your doctor or avoid drinking alcohol when taking Topiramate tablets. pharmacist. Pregnancy and breast-feeding • This medicine has been prescribed for you only. Do Pregnancy not pass it on to others. It may harm them, even if Migraine prevention: their signs of illness are the same as yours. Topiramate tablets can harm an unborn baby. You must • If you get any side effects, talk to your doctor or not take Topiramate tablets if you are pregnant. You must pharmacist. This includes any possible side effects not not take Topiramate tablets for migraine prevention if you listed in this leaflet. See section 4. are a woman of childbearing potential unless you are using • The full name of this medicine is Topiramate Accord effective contraception. Talk to your doctor about the best Healthcare 25mg, 50mg, 100mg and 200mg kind of contraception and whether Topiramate tablets Film-coated Tablets but within the leaflet it will be are suitable for you. Before the start of treatment with referred to as Topiramate tablets. Topiramate tablets, a pregnancy test should be performed. Treatment of epilepsy: If you are a woman of childbearing potential you should What is in this leaflet: talk to your doctor about other possible treatments instead 1 What Topiramate tablets are and what they of Topiramate tablets. If the decision is made to take are used for Topiramate tablets, you should use effective contraception. 2 What you need to know before you take Talk to your doctor about the best kind of contraception to use while you are taking Topiramate tablets. Before the Topiramate tablets start of treatment with Topiramate tablets a pregnancy test 3 How to take Topiramate tablets should be performed. 4 Possible side effects 5 How to store Topiramate tablets Talk to your doctor if you wish to become pregnant. As 6 Contents of the pack and other information with other antiepileptic medicines, there is a risk of harm to the unborn child if Topiramate tablets is used during pregnancy. Make sure you are very clear about the risks and the benefits of taking Topiramate tablets for epilepsy 1 What Topiramate tablets are and what they during pregnancy. are used for • If you take Topiramate tablets during pregnancy, your Topiramate belongs to a group of medicines called baby has a higher risk for birth defects, particularly, cleft antiepileptic medicines. It is used: lip (split in the top lip) and cleft palate (split in the roof of • alone to treat seizures in adults and children over age 6 the mouth). Newborn boys may also have a malformation • with other medicines to treat seizures in adults and of the penis (hypospadia). These defects can develop children aged 2 years and above early in pregnancy, even before you know you are • to prevent migraine headaches in adults. pregnant. • If you take Topiramate tablets during pregnancy, your 2 What you need to know before you take baby may be smaller than expected at birth. Talk to Topiramate tablets your doctor if you have questions about this risk during Do not take Topiramate tablets pregnancy. • if you are allergic to topiramate or any of the other • There may be other medicines to treat your condition ingredients of this medicine (listed in section 6). that have a lower risk of birth defects. • for migraine prevention do not take if you are pregnant • Tell your doctor straight away if you become pregnant or if you are a woman of childbearing potential unless you while taking Topiramate tablets. You and your doctor are using effective contraception (see ‘Pregnancy and should decide if you will continue to take Topiramate breast-feeding’ for further information). You should talk to tablets while you are pregnant. your doctor about the best kind of contraception to use while you are taking Topiramate tablets. Breast-feeding The active substance in Topiramate tablets (topiramate) Warnings and precautions passes into human milk. Effects have been seen in Talk to your doctor or pharmacist before taking breastfed babies of treated mothers, including diarrhoea, Topiramate tablets if you feeling sleepy, feeling irritable, and poor weight gain. • have, or have a family history of kidney stones or too Therefore, your doctor will discuss with you whether you much calcium in the urine abstain from breast-feeding or whether to abstain from • have other kidney problems, or are having kidney treatment with Topiramate tablets. Your doctor will take dialysis into account the importance of the medicine to the mother and the risk for the baby. • have a history of blood and body fluid abnormality (metabolic acidosis) Mothers who breastfeed while taking Topiramate tablets • have liver problems must tell the doctor as soon as possible if the baby • have eye problems, especially glaucoma experiences anything unusual. • have a growth problem • are on a high fat diet (ketogenic diet) Driving and using machines • are taking Topiramate tablets to treat epilepsy and you Dizziness, tiredness and vision problems may occur whilst are pregnant or a woman of childbearing potential taking Topiramate tablets. Do not drive or use any tools or (see section ‘Pregnancy and breast-feeding’ for further machines without talking to your doctor first. information). Topiramate tablets contain lecithin (soya oil) If you are not sure if any of the above applies to you, talk to Topiramate 50mg, 100mg and 200mg tablets contain your doctor or pharmacist before lecithin (soya oil). If you are allergic to peanuts or soya, do using Topiramate tablets. not use this medicinal product. It is important that you do not stop taking your medicine This medicine contains less than 1 mmol sodium without first consulting your doctor. (23mg) per film-coated tablet, that is to say essentially ‘sodium-free’. You should also talk to your doctor before taking any other medicine containing topiramate that is given to you as an 3 How to take Topiramate tablets alternative to Topiramate tablets. Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not You may experience weight loss while taking Topiramate sure. tablets. Therefore, your weight should be checked regularly Your doctor will usually start you on a low dose and slowly when using this medicine. If you are losing too much increase your dose until the best dose is found. weight or if a child using this medicine is not gaining enough weight, you should consult your doctor. The recommended dose is If you take Topiramate tablets only for epilepsy You should drink plenty of fluids while taking Topiramate • Adults – starting dose of 25mg at night. The dose will tablets, especially prior to and during activities such as be slowly increased to a maintenance dose, usually 100- exercise or being exposed to warm temperatures, as this 200mg a day in 2 divided doses. Maximum dose of 500mg may reduce the risk of heat-related side effects. a day in 2 divided doses. • Children over 6 years of age – starting dose of 0.5-1mg A small number of people being treated with anti-epileptic per kg of body weight at night increasing slowly to a medicines such as Topiramate tablets have had thoughts maintenance dose, usually 100mg a day. of harming or killing themselves. If at any time you have these thoughts, immediately contact your doctor. If you take Topiramate tablets with another epilepsy medicine Topiramate tablets may in rare cases cause high levels of • Adults – starting dose of 25-50mg at night. The dose will ammonia in the blood (seen in blood tests) which can lead be slowly increased to a maintenance dose, usually 200- to a change in brain function, especially if you are also 400mg a day in 2 divided doses. taking a medicine called valproic acid or sodium valproate. Since this may be a severe condition, tell your doctor • Children over 2 years of age – starting dose of 1-3mg immediately if the following symptoms occur (see also per kg of body weight at night increasing slowly to a section 4 ‘Possible side effects’): maintenance dose, usually 5-9mg per kg of body weight a day in 2 divided doses. • difficulty thinking, remembering information, or solving problems Prevention of migraines • being less alert or aware • Adults – starting dose of 25mg at night. The dose will be • feeling very sleepy with low energy slowly increased to a maintenance dose of 100mg a day At higher doses of Topiramate tablets, the risk of in 2 divided doses. developing these symptoms may increase. • Children – Not recommended for use in children. Other medicines and Topiramate tablets Swallow whole. Do not chew. Take with or without food. Tell your doctor or pharmacist if you are taking, have To prevent kidney stones while taking Topiramate tablets, recently taken or might take any other medicines. drink plenty of fluids during the day. Topiramate and certain other medicines can affect each other. Sometimes the dose of some of your other If you take more Topiramate tablets than you medicines or Topiramate tablets will have to be adjusted. should Especially, tell your doctor or pharmacist if you are taking: See a doctor right away.
Load more

Recommended publications
  • Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017
    Q UO N T FA R U T A F E BERMUDA PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 BR 111 / 2017 The Minister responsible for health, in exercise of the power conferred by section 48A(1) of the Pharmacy and Poisons Act 1979, makes the following Order: Citation 1 This Order may be cited as the Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017. Repeals and replaces the Third and Fourth Schedule of the Pharmacy and Poisons Act 1979 2 The Third and Fourth Schedules to the Pharmacy and Poisons Act 1979 are repealed and replaced with— “THIRD SCHEDULE (Sections 25(6); 27(1))) DRUGS OBTAINABLE ONLY ON PRESCRIPTION EXCEPT WHERE SPECIFIED IN THE FOURTH SCHEDULE (PART I AND PART II) Note: The following annotations used in this Schedule have the following meanings: md (maximum dose) i.e. the maximum quantity of the substance contained in the amount of a medicinal product which is recommended to be taken or administered at any one time. 1 PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 mdd (maximum daily dose) i.e. the maximum quantity of the substance that is contained in the amount of a medicinal product which is recommended to be taken or administered in any period of 24 hours. mg milligram ms (maximum strength) i.e. either or, if so specified, both of the following: (a) the maximum quantity of the substance by weight or volume that is contained in the dosage unit of a medicinal product; or (b) the maximum percentage of the substance contained in a medicinal product calculated in terms of w/w, w/v, v/w, or v/v, as appropriate.
    [Show full text]
  • 761089Orig1s000
    CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 761089Orig1s000 CLINICAL / STATISTICAL REVIEW(S) Safety Team Leader Review BLA 761089 Ajovy (Fremanezumab) Safety Team Leader Review Date September 14, 2018 From Sally Usdin Yasuda Subject Safety Team Leader Review NDA/BLA # BLA 761089 Supplement# Applicant Teva Pharmaceuticals USA, Inc. Date of Submission October 16, 2017 PDUFA Goal Date June 16, 2018 Proprietary Name / Non- Ajovy/Fremanezumab Proprietary Name Dosage form(s) / Strength(s) Solution for subcutaneous injection, 225 mg/1.5 ml Applicant Proposed Preventive treatment of migraine in adult patients Indication(s)/Population(s) There do not appear to be safety concerns that would preclude approval. If efficacy is demonstrated and the Recommendation on benefits of fremanezumab for prevention of migraine Regulatory Action outweigh the risks, then I recommend that approval include appropriate labeling language addressing any adverse reactions of concern. Recommended Indication(s)/Population(s) (if applicable) 1 Reference ID: 4320823 Safety Team Leader Review BLA 761089 Ajovy (Fremanezumab) 1. Background This memorandum summarizes the primary concerns from the safety review conducted by Dr. Lourdes Villalba of the fremanezumab BLA 761089 and provides my conclusions and recommendations regarding the safety findings and management of the risks. I also discuss the consultant reviews from Dr. Wiley Chambers (Division of Transplant and Ophthalmology Products). The product information and the applicant’s proposals Fremanezumab is a humanized monoclonal IgG2 antibody that, according to the Sponsor, is a calcitonin gene-related peptide (CGRP) binder that blocks both CGRP isoforms (α- and β) so that CGRP is blocked from binding to the CGRP receptor.
    [Show full text]
  • E Cacy and Safety of CGRP Monoclonal
    Ecacy and Safety of CGRP Monoclonal Antibodies for the Prevention of Migraine Compared with Placebo: A Systematic Review and Meta-Analysis Xiaojing Yi Hunan Normal University Yun Chen Hunan Normal University Kun Chen Hunan Normal University Mo Liu Hunan Normal University Jiale Yi Hunan Normal University Xiongwei Hu Hunan Normal University Guibin Wang ( [email protected] ) Research article Keywords: Migraine, Calcitonin gene-related peptide, Monoclonal antibodies, Preventive treatment, Meta-analysis Posted Date: July 14th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-39329/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/20 Abstract Background: Calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) are a novel class of drugs for migraine that includes erenumab, fremanezumab, galcanezumab and eptinezumab. In clinical trials, CGRP mAbs have been reported to show good ecacy in the prevention of episodic migraines or chronic migraines. Our aim was to evaluate the ecacy and safety of CGRP monoclonal antibodies in this study. Methods: We systematically searched for randomized controlled trials in the PubMed, Embase, ClinicalTrials.gov, and Cochrane Library databases. The primary outcome was overall mean change from baseline to end of treatment in the number of monthly migraine headache days (MMHDs). The secondary outcomes included 50% response rate, in the number of monthly headache days (MHDs), in the number of monthly headache hours (MHHs), and in the number of monthly acute migraine-specic medication days (MSMDs). The safety outcomes were evaluated in terms of reported adverse events. Results: Eighteen studies including 11,099 patients were included in the meta-analysis.
    [Show full text]
  • Treating Migraines: It's Different for Kids
    ® Priority Updates from the Research Literature PURLs from the Family Physicians Inquiries Network Matthew Hawks, MD; Anne Mounsey, MD Nellis AFB Family Medicine Treating migraines: Residency, Las Vegas, Nev (Dr. Hawks); Department of Family Medicine, The It’s different for kids University of North Carolina, Chapel Hill (Dr. Mounsey) Certain medications used for migraine prevention in DEPUTY EDITOR adults do not perform the same way in children and Shailendra Prasad, MBBS, MPH adolescents and can actually cause harm. Department of Family Medicine and Community Health, University of Minnesota, Minneapolis PRACTICE CHANGER Drug Administration (FDA) has not approved Do not prescribe amitriptyline or topiramate any medications for preventing migraines as preventive therapy for migraine in chil- in children younger than 12 years of age. dren; both drugs are no better than placebo However, surveys of pediatric headache for this population and are associated with specialists suggest that amitriptyline and increased rates of adverse events.1,2 topiramate are among the most commonly prescribed medications for childhood mi- STRENGTH OF RECOMMENDATION graine prophylaxis.3,4 A: Based on a single double-blind random- There is low-quality evidence from indi- ized control trial (RCT) and supported by a vidual randomized controlled trials (RCTs) meta-analysis of 4 RCTs. about the effectiveness of topiramate. A me- 1. Powers SW, Coffey CS, Chamberlin LA, et al; for the CHAMP Inves- ta-analysis by El-Chammas and colleagues tigators. Trial of amitriptyline, topiramate, and placebo for pediatric migraine. N Engl J Med. 2017;376:115-124. included 3 RCTs comparing topiramate to 2. Le K, Yu D, Wang J, et al.
    [Show full text]
  • Magnesium, Feverfew, and Riboflavin
    The Journal of the American Nutraceutical Association Vol. 6, No. 4, Fall 2003 Reprint Magnesium, Feverfew, and Riboflavin: Therapeutic Use in Migraine Prevention Lisa Colodny, Pharm D,1,2 Nordia Bryan, PharmD Candidate,1 Samantha Luong, PharmD Candidate,1 Jennifer Rooney, PharmD Candidate1 1. Department of Pharmacy, Coral Springs Medical Center, Coral Springs, Florida 2. Associate Clinical Professor, School of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida Case Reports on Patients Diagnosed with Migraine and Placed on A Nutraceutical Product Containing Riboflavin, Magnesium and Feverfew Andrea Cohen, MD Certified by the American Board of Psychiatry and Neurology the American Board of Holistic Medicine, and the American Society of Neurorehabilitation A Peer-Reviewed Journal on Nutraceuticals and Nutrition Editor-in-Chief Mark Houston, M.D. ISSN-1521-4524 Compliments of PR Osteo, LLC Reprinted with permission from the Journal of the American Nutraceutical Association. Duplication in whole or part is not permitted without permission. R EVIEW A RTICLE Magnesium, Feverfew, and Riboflavin: Therapeutic Use in Migraine Prevention Lisa Colodny, Pharm D,1,2 * Nordia Bryan, PharmD Candidate,1 Samantha Luong, PharmD Candidate,1 Jennifer Rooney, PharmD Candidate1 1. Department of Pharmacy, Coral Springs Medical Center, Coral Springs, Florida 2. Associate Clinical Professor, School of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida Approximately 28 to 32 million Americans suffer from nial vessels that leads to a decrease in blood flow to the migraine headaches. The majority of these are women brain, which may induce periods of low oxygenation that between the ages of 22 and 35 years. Although the causes of can result in neurologic disjunction.
    [Show full text]
  • Management of Migraines
    Management of Migraines Authors: Matt Brown, Pharm.D., 2014, Harrison School of Pharmacy, Auburn University; Katie Warren, Pharm.D., 2014, Harrison School of Pharmacy, Auburn University; Lydia Thornhill, Pharm.D., 2014, Harrison School of Pharmacy, Auburn University; Wesley T. Lindsey, Pharm.D., Clinical Associate Professor in Drug Information, Drug Information and Learning Resource Center, Harrison School of Pharmacy, Auburn University Universal Activity #: 0178-0000-14-104-H01-P | 1.25 contact hours (.125 CEUs) Initial Release Date: November 25, 2014 | Expires May. 1, 2016 Alabama Pharmacy Association | 334.271.4222 | www.aparx.org | [email protected] WINTER 2014: CONTINUING EDUCATION | WWW.APARX.ORG 1 EducatiONAL OBJECTIVES After the completion of this activity pharmacists will be able to: • Describe the clinical presentation of migraine headaches. • Discuss medications used in acute migraine treatment. • Discuss common medications for migraine prevention. INTRODUCTION a band around the largest part of the head. These headaches usually Migraine is one of the most common reasons adults in the occur around a time of stress and may persist for months. These United States present to the emergency department (ED).1 It types of headaches differ from migraines in that they lack aura; accounts for almost 3% of ED visits and annually costs anywhere they are also more prominent in men, whereas migraines are more between $1 to $17 billion. Migraines are known to affect common in women. approximately 23 million people in the U.S. alone. Those affected A migraine attack can be divided into several phases that include are most likely to be between the ages of 20 to 55, but migraines are the premonitory phase, migraine aura (if present), the migraine also seen in children as young as five as well as in the elderly.
    [Show full text]
  • Calcitonin Gene Related Peptide Antagonists Medical Policy (PDF)
    Medical benefit drug policies are a source for BCBSM and BCN medical policy information only. These documents are not to be used to determine benefits or reimbursement. Please reference the appropriate certificate or contract for benefit information. This policy may be updated and therefore subject to change. Effective Date: 08/12/2021 Calcitonin Gene Related Peptide (CGRP) Antagonists Vyepti® (eptinezumab-jjmr) FDA approval: February 21, 2020 HCPCS: J3032 Benefit: Medical Policy: Requests must be supported by submission of chart notes and patient specific documentation. A. Coverage of the requested drug is provided when all the following are met: a. Migraine Prevention: i. Medication is being used for preventive treatment of migraine headaches. ii. There is a persistent history of recurring debilitating headaches (4 or more headache days per month with migraine headache lasting for 4 hours per day or longer). iii. Adequate trials (at least 2 month trial) of prophylactic therapy from at least TWO different therapy classes listed in Appendix 1 were not effective, contraindicated, or not tolerated. iv. An evaluation has been performed to rule out rebound headaches caused by medication use and preventative steps have been taken. Medications that may be associated with rebound headache include, but are not limited to, narcotics, triptans exceeding more than 12 doses per month, caffeine, and NSAIDs. v. Not to be used in combination with other CGRP antagonists for migraine prevention b. FDA approved age c. Prescribed by or in consultation with a neurologist d. Trial and failure, contraindication, OR intolerance to the preferred drugs as listed in the BCBSM/BCN utilization management medical drug list and/or BCBSM/BCN’s prior authorization and step therapy documents B.
    [Show full text]
  • Review Article
    Headache ISSN 0017-8748 C 2006 by American Headache Society doi: 10.1111/j.1526-4610.2006.00370.x Published by Blackwell Publishing Review Article Ovarian Hormones and Migraine Headache: Understanding Mechanisms and Pathogenesis—Part 2 Vincent T. Martin, MD; Michael Behbehani, PhD Migraine headache is strongly influenced by reproductive events that occur throughout the lifespan of women. Each of these reproductive events has a different “hormonal milieu,” which might modulate the clinical course of migraine headache. Estrogen and progesterone can be preventative or provocative for migraine headache un- der different circumstances depending on their absolute serum levels, constancy of exposure, and types of estro- gen/progesterone derivatives. Attacks of migraine with and without aura respond differently to changes in ovarian hormones. Clearly a greater knowledge of ovarian hormones and their effect on migraine is essential to a greater understanding of the mechanisms and pathogenesis of migraine headache. Key words: menstrual migraine, migraine headache, estrogen, progesterone, menstrual cycle, menarche, pregnancy, menopause, lactation Abbreviations: GnRH gonadotropin-releasing hormone, HRT hormone replacement therapy, OCPs oral contra- ceptives, PROGINS progesterone receptor allele, CVA cerebrovascular accident, CNS central nervous system, CI confidence intervals, HR hazard ratio, MAO-B monoamine oxidase-B, NMDA N-methyl-d-aspartate, AUC area-under-the-curve, TNC trigeminal nucleus caudalis, GABA gamma aminobutyric acid (Headache 2006;46:365-386) During part 1 of this series, we reviewed the ge- pathogenesis of migraine headache. Numerous clini- nomic and nongenomic effects of ovarian hormones cal studies also exist to provide clues to how ovarian on the central nervous system as well as the current hormones might modulate migraine headaches.
    [Show full text]
  • Quality of Care Measures for Migraine: a Comprehensive Review
    Thomas Jefferson University Jefferson Digital Commons College of Population Health Faculty Papers Jefferson College of Population Health June 2007 Quality of care measures for migraine: a comprehensive review Joshua J. Gagne Thomas Jefferson University Brian Leas Thomas Jefferson University Jennifer H. Lofland Thomas Jefferson University Neil Goldfarb Thomas Jefferson University Frederick Freitag Diamond Headache Clinic Follow this and additional works at: https://jdc.jefferson.edu/healthpolicyfaculty See next page for additional authors Part of the Health Services Research Commons Let us know how access to this document benefits ouy Recommended Citation Gagne, Joshua J.; Leas, Brian; Lofland, Jennifer H.; Goldfarb, Neil; Freitag, Frederick; and Silberstein, Stephen, "Quality of care measures for migraine: a comprehensive review" (2007). College of Population Health Faculty Papers. Paper 39. https://jdc.jefferson.edu/healthpolicyfaculty/39 This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in College of Population Health Faculty Papers by an authorized administrator of the Jefferson Digital Commons. For more information, please contact: [email protected]. Authors Joshua J. Gagne, Brian Leas, Jennifer H. Lofland, Neil Goldfarb, rF ederick Freitag, and Stephen Silberstein This article is available at Jefferson Digital Commons: https://jdc.jefferson.edu/healthpolicyfaculty/39 DISEASE MANAGEMENT Volume 10, Number 3, 2007 © Mary Ann Liebert, Inc.
    [Show full text]
  • Drugs and Devices to Prevent Migraines in Adults
    Drugs and Devices to Prevent Migraines in Adults Results of Topic Selection Process & Next Steps The nominator is interested in an update to a 2013 AHRQ evidence review on preventative pharmacology for migraines in adults. The nominator is concerned with the currency of the information presented in the archived review, and believes an update would inform the public about new preventative treatments for migraines in adults. Due to limited program resources, the Effective Health Care (EHC) program will not develop a review at this time. No further activity on this topic will be undertaken by the EHC Program. Topic Brief Topic Name: Drugs and Devices to Prevent Migraines in Adults Topic #: 0703 Nomination Date: September 14, 2016 Topic Brief Date: March 2017 Authors Kara Winchell Rose Revelo Conflict of Interest: None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report. Summary of Key Findings • Appropriateness and importance: The nomination is both appropriate and important. • Duplication: While specific interventions on the prevention of migraines have been well reviewed, there is no recent comprehensive review, and a new AHRQ evidence review would therefore not be duplicative. o The Canadian Headache Society performed a high quality systematic review and published a guideline on migraine prophylaxis, which included subgroup analyses on pregnant women and comorbidities. This review was published in 2012 but the search dates are more recent than those of the 2013 AHRQ review. Five separate Cochrane reviews examined SSRI/SNRIs; gabapentin and pregabalin; Valproate; topiramate; and anticonvulsants other than the aforementioned anticonvulsants for prevention of episodic and chronic migraine.
    [Show full text]
  • The Selection and Use of Essential Medicines
    This report contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the World Health Organization WHO Technical Report Series 933 THE SELECTION AND USE OF ESSENTIAL MEDICINES Report of the WHO Expert Committee, 2005 (including the 14th Model List of Essential Medicines) World Health Organization Geneva 2006 i WHO Library Cataloguing-in-Publication Data WHO Expert Committee on the Selection and Use of Essential Medicines (14th : 2005: Geneva, Switzerland) The selection and use of essential medicines : report of the WHO Expert Committee, 2005 : (including the 14th model list of essential medicines). (WHO technical report series ; 933) 1.Essential drugs — standards 2.Formularies — standards 3.Drug information services — organization and administration 4.Drug utilization 5. Pharmaceutical preparations — classification 6.Guidelines I.Title II.Title: 14th model list of essential medicines III.Series. ISBN 92 4 120933 X (LC/NLM classification: QV 55) ISSN 0512-3054 © World Health Organization 2006 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 2476; fax: +41 22 791 4857; email: [email protected]). Requests for permission to reproduce or translate WHO publica- tions — whether for sale or for noncommercial distribution — should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; email: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.
    [Show full text]
  • Migraine: Burden of Disease, Treatment, and Prevention
    Osteopathic Family Physician (2013) 5, 116–122 Migraine: Burden of disease, treatment, and prevention Natasha N. Bray, DO,a Aaron Heath, DO,b Julietta Militello, DOb From aNova Southeastern University, College of Osteopathic Medicine, Fort Lauderdale, FL; and bBroward Health/Broward Health Medical Center, Fort Lauderdale, FL KEYWORDS: Abstract Migraines are perhaps the most studied of the headache syndromes secondary to the high Migraine; incidence and have significant effect on the quality of life of those suffering from this condition. Headache Despite the high prevalence of migraines, an estimated two-thirds of sufferers either have never consulted a doctor or have stopped doing so. Therefore, it is an underdiagnosed and undertreated condition. The prevalence of migraine attacks is estimated to be 17% in women and 6% in men each year. Evidence-based guidelines for both the immediate treatment as well as preventive therapy have been established. These guidelines outline several management strategies for migraine headaches, including immediately aborting the migraine at the onset of headache, controlling the pain once it has fully evolved, and prophylactic therapy. Abortive treatment should be initiated as soon as an aura or other warning sign is noted. Patient education plays an integral role in any management plan. Headache journals may help patients identify and avoid migraine triggers and document the response to therapeutic intervention. Physicians must be aware of warning signs that may reflect more severe underlying pathology and when neuroimaging, neurology consultation, and hospitalization are warranted. Published by Elsevier Inc. Migraine prevalence and disease burden those older than 60 years of age (Figure 1).
    [Show full text]