(12) Patent Application Publication (48) Pub
US 20090226407A9 (19) United States (10) Pub. No.: US 2009/0226407 A9 (12) Patent Application Publication (48) Pub. Date: Sep. 10, 2009 L0ScalZ0 et al. CORRECTED PUBLICATION (54) METHODS OF TREATING VASCULAR (60) Provisional application No. 60/179,020, filed on Jan. DISEASES CHARACTERIZED BY NITRC 31, 2000. Provisional application No. 60/162,230, OXIDE INSUFFICIENCY filed on Oct. 29, 1999. Provisional application No. 60/179,020, filed on Jan. 31, 2000. Provisional appli (76) Inventors: Joseph Loscalzo, Dover, MA (US); cation No. 60/162,230, filed on Oct. 29, 1999. Joseph A. Vita, Hingham, MA (US); Michael D. Loberg, Boston, MA (US); Publication Classification Manuel Worcel, Boston, MA (US) (51) Int. Cl. Correspondence Address: A6II 38/43 (2006.01) WILMERHALEANTROMED AOIN 43/04 (2006.01) 1875 PENNSYLVANIAAVE, NW (52) U.S. Cl. .............................................. 424/94.1: 514/23 WASHINGTON, DC 20006 (US) (21) Appl. No.: 10/692,724 (57) ABSTRACT (22) Filed: Oct. 27, 2003 The invention provides methods of treating and/or preventing vascular diseases characterized by nitric oxide insufficiency Prior Publication Data by administering atherapeutically effective amount of at least one nitrosated angiotensin-converting enzyme inhibitor, nit (15) Correction of US 2004/0105850 A1 Jun. 3, 2004 rosated beta-adrenergic blocker, nitrosated cholesterol reducer, nitrosated calcium channel blocker, nitrosated See (60) Related U.S. Application Data. endothelin antagonist, nitrosated angiotensin II receptor (65) US 2004/0105850 A1 Jun. 3, 2004 antagonist, nitrosated renin inhibitor, and optionally at least one compound used to treat cardiovascular diseases and/or at Related U.S. Application Data least one antioxidant, or a pharmaceutically acceptable salt thereof, and/or at least one compound that donates, transfers (60) Continuation-in-part of application No.
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