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23Rd Annual SAN ANTONIO BREAST CANCER SYMPOSIUM —

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23Rd Annual SAN ANTONIO BREAST CANCER SYMPOSIUM — Breast Cancer Research and Treatment CONTENTS VOLUME 64, No. 1, 2000 23rd Annual SAN ANTONIO BREAST CANCER SYMPOSIUM – December 6–9, 2000 Program 1–25 Abstracts General Sessions [#1–38] 26–35 Poster Session I [#101–180] (Wednesday, December 6, 5:00–7:00 pm) 36–55 Poster Session II [#201–280] (Thursday, December 7, 7:30–9:30 am) 56–75 Poster Session III [#301–380] (Friday, December 8, 7:30–9:30 am) 76–95 Poster Session IV [#401–480] (Friday, December 8, 5:00–7:00 pm) 96–115 Poster Session V [#501–580] (Saturday, December 9, 7:30–9:30 am) 116–135 Author index for abstracts 137–146 Instructions for authors, Breast Cancer Research and Treatment 147–151 Photocopying. In the U.S.A.: This journal is registered at the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923. Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Kluwer Academic Publishers for users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the fee of USD 18.00 per copy is paid directly to CCC. For those organizations that have been granted a photocopy licence by CCC, a separate system of payment has been arranged. The fee code for users of the Transactional Reporting Service is 0167–6806/2000/USD 18.00. Authorization does not extend to other kinds of copying, such as that for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. In the rest of the world: Permission to photocopy must be obtained from the copyright owner. Please apply to Kluwer Academic Publishers, P.O. Box 17, 3300 AA Dordrecht, The Netherlands. Breast Cancer Research and Treatment is published monthly plus 1 additional issue in January, March, May, July, September and November (2000). Subscription prices for 2000, Volumes 59–64 (3 issues each) are: For institutions NLG 2850.00/EURO 1293.27/USD 1357.00 including postage and handling. For individuals NLG 1320.00/EURO 598.99/USD 660.00 including postage and handling. Periodicals postage paid at Rahway, N.J. USPS No. 663–130. U.S. Mailing Agent: Mercury Airfreight International Ltd., 365 Blair Road, Avenel, NJ 07001. Published by Kluwer Academic Publishers, Spuiboulevard 50, P.O. Box 17, 3300 AA Dordrecht, The Netherlands, and 101 Philip Drive, Norwell, MA 02061, U.S.A. Postmaster: Please send all address corrections to: Breast Cancer Research and Treatment c/o Mercury Airfreight International Ltd., 365 Blair Road, Avenel, NJ 07001, U.S.A. Printed on acid-free paper San Antonio Breast Cancer Symposium - Wednesday 3 WEDNESDAY, DECEMBER 6 2:45 4. Selection of High Risk Lymph Node Negative Breast Cancer Patients for Chemotherapy Can Best Be Done with the Mitotic Activity Index. 9:00-9:15 WELCOME Van Diest PJ, Baak JPA, and other MMCP Collaborators of Pathology. Free University Hospital, Amsterdam, The Opening Remarks Netherlands. Charles A. Coltman, Jr., MD 3:00 5. Indicators of Lifetime Estrogen Exposure: Effect on 9:15-12:00 MINI-SYMPOSIUM I Breast Cancer Incidence and Interaction with Raloxifene Therapy in MORE Trial Participants. Microarray-Based Analysis of Breast Cancer Lippman ME, Krueger KA, Eckert S, Cauley JA, Walls EL, Peter O’Connell, PhD, Moderator Jamal S, Cummings SR, and the Prevention Sciences Group. Baylor College of Medicine, Houston, Texas Lombardi Cancer Center, Georgetown University Medical 9:15 Introduction Center; Eli Lilly and Co.; University of Pittsburgh; Women’s College Hospital, Toronto; UCSF. 9:15 Array-Based Comparative Genomic Hybridization 3:15 6. Comparison of Efficacy and Tolerability of Fulvestrant Analysis of Breast Cancer Joe W. Gray, PhD (Faslodex™) with Anastrozole (Arimidex™) in Post- Menopausal Women with Advanced Breast Cancer – University of California San Francisco, California Preliminary Results. Howell A, Robertson JFR, Quaresma Albano J, 9:50 In Vivo Gene Expression Profiling of Human Breast Aschermannova A, Mauriac L, Kleeberg UR, Vergote I, Cancer Progression Erikstein B, Webster A, Morris C. Christie Hospital, Abdel G. Elkahloun, PhD Manchester, United Kingdom; City Hospital, Nottingham, National Human Genome Research Institute, NIH United Kingdom; Instituto De Oncologicia, Coimbra, Bethesda, Maryland Portugal; Odborny Lecebny Ustav Onkol., Nova Ves Pod 10:25 Molecular Characterization and Classification of Plesi, Czech Republic; Institut Bergonnie, Bordeaux, Human Breast Tumors Using cDNA Microarrays France; Haemat./Onkol. Praxis, Hamburg, Germany; Charles M. Perou, PhD University Hospital, Leuven, Belgium; Radiumhospital Stanford University Onkologisk Aveling, Oslo, Norway; AstraZeneca, Stanford, California Macclesfield, United Kingdom. 11:00 Translation of Array Results to the Clinic 3:30 7. A Double-Blind Randomized Trial Comparing the Susan G. Hilsenbeck, PhD Efficacy and Tolerability of FaslodexTM (Fulvestrant) Baylor College of Medicine with ArimidexTM (Anastrozole) in Post-Menopausal Houston, Texas Women with Advanced Breast Cancer. Osborne CK, on Behalf of the North American Faslodex 11:35 Panel Discussion Investigator Group. Baylor College of Medicine, Houston, TX. 12:00-1:00 LUNCH [Ticket Required] 3:45 8. Femara® (Letrozole) Showed Significant Improvement in Efficacy over Tamoxifen as First-Line Treatment in 1:00-2:00 WILLIAM L. MCGUIRE Postmenopausal Women with Advanced Breast Cancer. MEMORIAL LECTURE Smith R, Sun Y, Garin A, Fein L, Sleeboom HP, Chaudri H, Dugan M, Staffler B, Brady C, on Behalf of the Letrozole Molecular Markers in Breast Cancer: Where Are International Breast Cancer Study Group. South Carolina We, Where Are We Going? Oncology Associates, Columbia, SC; Cancer Hospital, Trevor J. Powles, MD PhD Beijing, China; Cancer Research Center, Moscow, Russia; Royal Marsden Hospital Centro Oncologico, Rosario, Argentina; Ziekenhuis Sutton, Surrey, England, UK Leyenburg, Den Haag, The Netherlands; Novartis Pharma, Supported by an educational grant from Glaxo Wellcome Basel, Switzerland. 4:00 9. Sulfotransferase Expression in Normal and Cancerous 2:00-5:00 GENERAL SESSION I Human Breast Tissues. Falany CN, Wang J, Falany JL, Frost AR. University of 2:00 1. Early Results of Breast Cancer Lymphatic Mapping Alabama at Birmingham, Birmingham, AL. from the H. Lee Moffitt Cancer Center: No Axillary 4:15 10. Resistance of Mutant BRCA1 Breast Cancer Cells to Recurrences in Breast Cancer Patients after a Negative Paclitaxel-Induced Apoptosis Mediated by Bcl-2. Sentinel Lymph Node Biopsy. Turner BC, Ren Q, Gupta PK, Basu A, Krajewski S, Dessureault S, Dupont E, Shons A, Berman C, Ku NN, Cox Krajewska M, Potoczek M, Carbone CJ, Reed JC, Haldar S. C, Reintgen D. H. Lee Moffitt Cancer Center and Research Thomas Jefferson University Hospital, Philadelphia, PA; Institute at the University of South Florida, Tampa, FL. Case Western Reserve University, Cleveland, OH; The 2:15 2. Axillary Node Examination Is a Weaker Indicator of Burnham Institute, La Jolla, CA. Metastatic Potential for Inner Quadrant Compared to 4:30 11. Akt2 Upregulation in HER-2/neu Overexpressing Breast Outer Quadrant Breast Cancers. Cancers: Implications to Their Clinical and Biological Tan WW, Herman TS, Ravdin PM. University of Texas Behavior. Health Science Center, San Antonio, TX. Bacus SS, Esteva FJ, Hortobagyi G, Gudkov AV. 2:30 3. Identification of Occult Metastatic Cells in Bone Marrow Quantitative Diagnostics Laboratory, Elmhurst, IL; UT MD Predicts Poor Prognosis Better Than HER2/neu Status Anderson Cancer Center, Houston, TX; University of and Angiogenesis in Breast Carcinomas. Illinois College of Medicine, Chicago, IL. Braun S, Schindlbeck C, Schaffer P, Atkinson R. Technical 4:45 12. Telomerase Activity in Human Breast Cancer. Univ., Munich, Germany; Ludwig-Maximilians Univ., Mokbel K, Hu JCC, Kirkpatrick K, Ghilchik M, Parris C, Munich, Germany; Univ. of Southern California, Los Newbold R. St Bartholomew’s Hospital, London, United Angeles, CA. Kingdom. 4 San Antonio Breast Cancer Symposium - Wednesday 5:00-7:00 POSTER SESSION I & 112 Effect of Blue Dye on Pulse Oximetry during Sentinel Node RECEPTION Biopsy. Khonji NI, Clarke D, Goyal S, Mukhtar Z, Al-Rawi K, Sweetland HM, Mansel RE. University of Wales College of Detection/Diagnosis Medicine, Cardiff, United Kingdom. 113 The Intradermal Sentinel Node: Update 2000. Axillary/Sentinel Nodes Owen DH. Betty Seinfeld Breast Ctr., Boyton Beach, FL. 114 Predictive Value of the Sentinel Lymph Node in Breast 101 The Almanac Trial: Initial Experience. Cancer: How Many Sentinel Nodes Are Enough? Mansel RE, on Behalf of ALMANAC Collaborators Group. Zervos EE, Farrar WB, Walker MJ, Yee LD, Young DC, Burak Cardiff, United Kingdom. WE. Arthur G. James Cancer Center at The Ohio State 102 Physiologic and Socioeconomic Consequences of Breast University, Columbus, OH. Cancer Surgery: A Comparison between Sentinel Lymph 115 Effect of Technetium 99m Sulphur Colloid Injection Interval Node Biopsy and Axillary Lymph Node Dissection. (TII) on Sentinel Node Biopsy. Burak WE Jr., Hollenbeck ST, Zervos EE, Young DC. The Chua AN, Lannin DL, Swanson MS, Tafra L. East Carolina Ohio State University, Arthur G. James Cancer Hospital, and University, Greenville, NC; Anne Arundel Medical Center, Richard J. Solove Research Institute, Columbus, OH. Annapolis, MD. 103 Quantitative Real-Time RT-PCR Detection of Breast Cancer 116 Predictors of Nonsentinel Node Metastasis in Breast Cancer Micrometastasis Using a Multi-Gene Marker Panel. Patients: Size and Extracapsular Extension of the Sentinel Mitas M, Mikhitarian K, Walters C, Baron P, Elliot B, Brothers Node Metastasis. T, Robison J, Metcalf JS, Gillanders WE, Cole DJ. Medical Stitzenberg KB, Calvo BF, Neelon BH, Iacocca MV, Ollila University of South Carolina, Charleston, SC. DW. University of North Carolina, Chapel Hill, NC. 104 Detection of Axillary Node Positivity Is Increased with 117 Patterns of Internal Mammary Drainage during Sentinel Sentinel Lymph Node Biopsy in Early Stage Breast Node Lymphoscintigraphy. Carcinoma. Smitt MC, Bevan A, Strauss HW, Jeffrey SS. Stanford Bevilacqua JLB, Van Zee KJ, Mann GB, Tan LK, Cody HS III, University, Stanford, CA. Heerdt AS, Montgomery LL, Petrek J, Borgen PI, Port ER.
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