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XXI SIMPOSIO DE REVISIONES EN CÁNCER Tratamiento Médico Del 7 mm revisionesrevisionesrevisiones en en en Vol. 33, Supl. 1 Vol. 2019: 1-153 Vol. 33, Supl. 1 Vol. 2019: 1-153 33, Supl. 1 Vol. 2019: 1-153 CÁNCERCÁNCERCÁNCER XXIXXIXXI SIMPOSIOSIMPOSIOSIMPOSIO DEDEDE REVISIONESREVISIONESREVISIONES ENENEN CÁNCERCÁNCERCÁNCER TratamientoTratamientoTratamiento médico médico médico del del del cáncer cáncer cáncer en en en el el el año año año 2019 2019 2019 VOL.VOL.VOL. 33, 33,33, SUPL. SUPL.SUPL. 1, 1, 1, 2019 20192019 CP-76136 - Fecha revisión enero 2019 CP-76136 - Fecha revisión enero 2019 CP-76136 - Fecha revisión enero 2019 VVViiciccttotoorririaiaasss e eennn C CCááánnnccceeerrr CadaCadaCada paciente paciente paciente con con con cáncer cáncer cáncer afrontará afrontará afrontará su su supropio propio propio y yúnico yúnico único camino. camino. camino. Juntos,Juntos,Juntos, contigo, contigo, contigo, estamos estamos estamos comprometidos comprometidos comprometidos a aayudarle aayudarle ayudarle a a a redefinirredefinirredefinir ese ese ese camino. camino. camino. EnEnEn Janssen Janssen Janssen Oncology, Oncology, Oncology, dedicamos dedicamos dedicamos nuestro nuestro nuestro esfuerzo esfuerzo esfuerzo a a a investigarinvestigarinvestigar y yproporcionar yproporcionar proporcionar las las las soluciones soluciones soluciones más más más innovadoras innovadoras innovadoras paraparapara ayudar ayudar ayudar a alos alos los pacientes pacientes pacientes y yprofesionales yprofesionales profesionales sanitarios sanitarios sanitarios a a a lograrlograrlograr más más más Victorias Victorias Victorias en en en Cáncer Cáncer Cáncer. XXI SIMPOSIO DE REVISIONES EN CÁNCER XXI SIMPOSIO DE REVISIONES EN CÁNCER XXI SIMPOSIO DE REVISIONES EN CÁNCER EnEn CPRCm* CPRCm* ENEN C PCRPCm*RCm* 77 A AÑÑOSOS JU JUNNTTOOSS CP-76136 - Fecha revisión enero 2019 CP-76136 - Fecha revisión enero 2019 CP-76136- Fecha revisión enero 2019 CP-76136- Fecha revisión enero 2019 5533,,66mmeseesse1#s 1# MeMedianadiana de de Su Supeprevirvvievneciancia Gl Goblobal al GruGpruo p1:o P acien1: Pacientes tcones con CPR CPCmRC enm tenrat tamienratamiento conto con Zytiga®Zytiga® + p r+e pdrniesdonanisona asin atsomáintomáticosticos/sin/ dolorsin dolor (BPI (B-SFPI -SF0-1 )0,-1), PSAP <SA 80 < n80g/ nmLg/ mLy p uny ptunuacióntuación Gle Gasloneas <on 81 < 81 ANAÁNLIÁSILSI SIS DE DESET ESRATTRIAFITCIFAICIAÓCNIÓ DNE DLOE SLOS DATDOATSO DSE LD AELN AÁNLIÁSILSI SFIISN FAINL ADLE LD ESTUDIOEL ESTUDIO COU-AA-302 COU-AA-3021 1 # La mediana# La mediana de SG de fue SG 53,6 fue 53,6meses meses vs. 41,8 vs. 41,8meses meses [HR: [HR: 0,61 0,61(IC 95%; (IC 95%; 0,43-0,87) 0,43-0,87) p: 0,006] p: 0,006] en el en grupo el grupo 1 comparado 1 comparado con con 31,2 meses31,2 meses vs. 28,4 vs. 28,4 meses meses [HR: [HR: 0,84 0,84 (IC 95%; (IC 95%; 0,72-0,99) 0,72-0,99) p: 0,03] p: 0,03] en el en grupo el grupo 21. 21. * Zytiga* Zytiga está estáindicado indicado con conprednisona prednisona en pacientes en pacientes adultos adultos con conCáncer Cáncer de Próstata de Próstata Resistente Resistente a la Castracióna la Castración metastásico metastásico asinto- asinto- máticos máticos o levemente o levemente sintomáticos sintomáticos tras trasprogresión progresión a TDAs a TDAs en los en cuales los cuales la quimioterapia la quimioterapia no está no estáaún clínicamenteaún clínicamente indicada indicada2. 2. 1. M1.ill eMr Kill,e er tK a,l .e Thet al. ThePhase Phase 3 COU-AA-302 3 COU-AA-302 Study Study of Abiraterone of Abiraterone Acetate Acetate Plus PlusPrednisone Prednisone in Men in Men with with Chemotherapy-naïve Chemotherapy-naïve Metastatic Metastatic Castration-resistant Castration-resistant Prostate Prostate Cancer: Cancer: Stratified Stratified Analysis Analysis Based Based on Pain, on Pain, Prostate-specific Prostate-specific Antigen, Antigen, and and *Zytiga*Zytiga® está® estáindicado indicado con prednisonacon prednisona para parael tratamiento el tratamiento del cáncer del cáncer de próstata de próstata metastásico metastásico resistente resistente a la castración a la castración (CPRCm) (CPRCm) en en Gleason Gleason Score. Score. Eur UrolEur Urol 2018; 2018; 74:17-23. 74:17-23. hombreshombres adultos adultos que seanque sean asintomáticos asintomáticos o levemente o levemente sintomáticos sintomáticos tras eltras fracaso el fracaso del tratamiento del tratamiento de deprivación de deprivación de andrógenos de andrógenos en los en los cualescuales la quimioterapia la quimioterapia no está no estáaún clínicamenteaún clínicamente indicada indicada1 (Aprobado1 (Aprobado en Diciembre en Diciembre 2012) 2012)2 y el2 tratamiento y el tratamiento del CPRCm del CPRCm en hombres en hombres adultos adultos 2. Fic2h. aF itcéhcani tcéac nidec aZ ydtei gZay®tiga® cuyacuya enfermedad enfermedad ha progresado ha progresado durante durante o tras o untras régimen un régimen de quimioterapia de quimioterapia basado basado en docetaxel en docetaxel1 (Aprobado1 (Aprobado en Septiembre en Septiembre 2011) 2011)2. 2. 1. Ficha1. Ficha técnica técnica Zytiga Zytiga®. 2.® European. 2. European Commission, Commission, public public health, health, community community register register of medicinal of medicinal products. products. DisponibleDisponible en: http://ec.europa.eu/health/documents/communityregister/html/h714.htm en: http://ec.europa.eu/health/documents/communityregister/html/h714.htm Último Último acceso acceso enero enero 2019. 2019. Director: Prof. Dr. E. Díaz-Rubio (Madrid) Redactor Jefe: Dr. J. A. García Sáenz (Madrid) Consejo Editorial: Prof. E. Aranda (Córdoba) Dr. E. Lizón Giner (Alicante) Dr. F. Cabanillas (Houston, EE.UU.) Dr. J. J. López López (Barcelona) Dr. P. Correa (New Orleans, EE.UU.) Dr. M. Markman (Nueva York, EE.UU.) Dr. H. Cortés-Funes (Madrid) Prof. A. Matilla (Málaga) Prof. J. Cruz Hernández (Salamanca) Dr. J. A. Moreno Nogueira (Sevilla) Dr. A. Duque Amusco (Sevilla) Dr. E. Murillo Capitán (Sevilla) Prof. D. Espinós (Madrid) Dr. S. Paulovsky (Buenos Aires, Argentina) Prof. J. Estapé (Barcelona) Dr. R. Pérez Carrión (Madrid) Dr. J. M. Fernández Rañada (Madrid) Dr. G. Pérez Manga (Madrid) Prof. J. García-Conde Bru (Valencia) Prof. R. Rosell Costa (Barcelona) Prof. M. González Barón (Madrid) Dr. A. Subías (Barcelona) Dr. C. Herránz Fernández (Valencia) Prof. T. Taguchi (Osaka, Japón) Prof. G. N. Hortobagyi (Houston, EE.UU.) Dr. J. Vicente Fernández (Madrid) Prof. J. Klastersky (Bruselas, Bélgica) Dr. P. Viladiú Quemada (Gerona) Dr. E. Lanzós González (Madrid) Dr. A. Villar Grimalt (Valencia) Dr. E. Lasalvia (Montevideo, Uruguay) Dr. J. Wils (Roermond, Holanda) Dr. M. de Lena (Bari, Italia) © Copyright 2019. ARÁN EDICIONES, S.L. Reservados todos los derechos. Ninguna parte de esta publicación puede ser reproducida, transmitida en ninguna forma o medio alguno, electrónico o mecánico, incluyendo fotocopias, grabaciones o cualquier sistema de recuperación de almacena- je de información, sin la autorización por escrito del titular del Copyright. La Editorial declina toda responsabilidad sobre el contenido de los artículos que aparezcan en esta publicación. REVISIONES EN CÁNCER se distribuye exclusivamente entre los profesionales de la Medicina. Publicación bimestral. Publicación autorizada por el Ministerio de Sanidad como Soporte Válido, Ref. SVP. Núm. 568. ISSN 0213-8573. Depósito Legal: M-19548-1987. Esta publicación se encuentra indexada en: Scopus, EMBASE (Excerpta Médica), Latindex ARÁN EDICIONES, S. L. c/ Castelló, 128, 1.º - 28006 Madrid - Telf.: 91 782 00 30 - Fax: 91 561 57 87 Departamento de Suscripciones: Telf. 91 782 00 34 - e-mail: [email protected] Departamento Editorial: Telf. 91 782 00 35 http://www.grupoaran.com SUMARIO VOL. 33 SUPL. 1 Sunitinib: estándar del tratamiento en cáncer renal 12 años después E. Esteban González, C. Álvarez, P. Solís, M. Izquierdo, S. Fernández, A. Castillo, M. Muñiz, P. Jiménez, A. Revuelta, C. Iglesias, D. Gómez, J. del Río, S. Valcárcel, J. L. García Llano 1 Cabozantinib, avanzando en la primera línea del carcinoma de células renales avanzado G. A. de Velasco Oria de Rueda 5 Objetivo del tratamiento del cáncer renal: supervivencia y calidad de vida de los pacientes C. Suárez Rodríguez 7 Tivozanib: ¿hace falta un nuevo TKI en 1L de CCR? J. Puente Vázquez 9 Posición actual y horizonte de pembrolizumab en el cáncer urotelial E. Grande Pulido 11 Atezolizumab como una realidad en la práctica clínica en carcinoma urotelial metastásico A. Gómez de Liaño 13 ¿Dónde estamos hoy? J. Puente Vázquez 14 Enzalutamida: el valor de la experiencia en un nuevo horizonte E. Gallardo Díaz 16 ¿Qué trae el futuro de enzalutamida? E. González Billalabeitia 20 Non metastatic castration-resistant prostate cancer A. Rodríguez-vida 22 Abiraterona en cáncer de próstata hormono-sensible metastásico Á. Pinto Marín 24 Chemo-Continuum, cabazitaxel tras docetaxel en la era de las terapias dirigidas N. Laínez Milagro 26 Inmunoterapia en el tratamiento del cáncer de cabeza y cuello R. Mesía Nin 29 Del ensayo clínico a la práctica clínica: Opdivo® en primera línea posplatino A. Rueda Domínguez 32 Manejo del paciente con cáncer de cabeza y cuello recidivado/metastásico sintomático Y. Escobar Álvarez 34 Lenvatinib en el tratamiento sistémico de primera línea en cáncer diferenciado de tiroides J. Capdevila Castillón 36 Estado del arte en primera línea de CPNM en pacientes sin mutaciones driver R. García Campelo, J. Mosquera Martínez, P. Cordeiro González 39 Perfiles de pacientes en primera línea de CPNM sin mutacionesdriver: monoterapia frente a combinación J. A. Rodríguez-García, E. González-Rodríguez, D. Rodríguez-Abreu
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