The Neuromeric Model of Brain Development/Evolution
12.12.12
Thursday, December 13, 12 Replication and Segmentation
Thursday, December 13, 12 DV patterning of neural tube (the Bauplan)
Jessell 2000
Thursday, December 13, 12 DV patterning of neural tube in forebrain (the Bauplan)
Puelles and Rubenstein 2003
Thursday, December 13, 12 The Columnar model of JB Johnson and CJ Herrick (First World War and onwards) Anterior
Dorsal
Anterior Posterior Left Right
Ventral
Posterior
Thursday, December 13, 12 Segmentation
Thursday, December 13, 12 Hox genes
Thursday, December 13, 12 Loss of function (Antennapaedia)
Gain of function (Bithorax)
Thursday, December 13, 12 Somites and evolution
Richardson et al. 1998
Thursday, December 13, 12 Hox genes
Thursday, December 13, 12 Hox genes
Thursday, December 13, 12 The Neuromeric model of Von Kuppfer, His and Orr (Pre War) Anterior
Dorsal
Anterior Posterior Left Right
Ventral
Posterior
Thursday, December 13, 12 Rhombomeres
Lumsden and Keynes 1989
Thursday, December 13, 12 Rhombomeres as compartments
Lumsden 2004
Thursday, December 13, 12 Rhombomeres and cranial nerves Chick Human
Lumsden and Keynes 1989
Thursday, December 13, 12 Hox genes provide a unique code for rhombomere identity while other genes set up boundaries
Hauptmann et al. 2002
Thursday, December 13, 12 Knockdown and ectopic expression of hoxb-1
Lumsden 2004
Thursday, December 13, 12 The Neuromeric model with a kink
Dorsal Dorsal
Anterior Posterior
Ventral Ventral
Dorsal Dorsal
Anterior Posterior
Ventral Ventral
Flexure
Thursday, December 13, 12 Vestigial anatomical designations of the columnar model that can be explained by neuromeric model with a kink
Dorsal
Epithalamus
Dorsal thalamus Anterior Posterior Ventral thalamus
Hypothalamus
Ventral
Thursday, December 13, 12 Original Prosomere model
Bulfone et al. 1993
Thursday, December 13, 12 Original Prosomere model
Puelles and Rubenstein 1993
Thursday, December 13, 12 Segmental scaffold of primary axon fascicles
Figdor and Stern 1993
Thursday, December 13, 12 Lineage restriction
Figdor and Stern 1993
Thursday, December 13, 12 Ectopic expression of mesomere homeobox gene Otx-2 rostralizes a rhombomere
Hidalgo-Sanchez et al. 2005
Thursday, December 13, 12 New conservative Prosomere model
Puelles 2009
Thursday, December 13, 12 Neuromeres are not added throughout vertebrate evolution
Scholpp and Lumsden 2010
Thursday, December 13, 12 Organizers and chemical signals
Kiecker and Lumsden 2003, 2012
Thursday, December 13, 12 Puelles and Rubenstein 2003
Thursday, December 13, 12 Puelles and Rubinstein 2003
Thursday, December 13, 12