Harvard University April 26-28, 2017

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EDITORIAL ASPIRATIONS HUMAN INTEGRITY AT THE FRONTIERS OF BIOLOGY OPENING PANEL WEDNESDAY, APRIL 26 HARVARD UNIVERSITY Emerson Hall, Room 105, 5-6:30pm APRIL 26-28, 2017 Anthony Appiah (New York University) 2:00pm Mechanisms of Deliberation and Oversight George Church (Harvard Medical School) Françoise Baylis (Dalhousie University), Peter Mills (Nuffield Council, UK), Erik Parens (Hastings Center), Abha Saxena Glenn Cohen (Harvard Law School) (WHO), Robert Truog (HMS), Christiane Woopen (University Sheila Jasanoff (Harvard Kennedy School) of Cologne) 4:00pm What Role for Publics? Feng Zhang (Broad Institute) Kevin Finneran (NAS), Bryan Hehir (HKS), Ben Hurlbut (ASU), Buhm Soon Park (KAIST, S. Korea), Rachel Salzman WORKSHOP (Stop ALD), Tania Simoncelli (Broad Institute) THURSDAY, APRIL 27 Tsai Auditorium, CGIS South FRIDAY, APRIL 28 8:45am Opening Remarks 9:00am Roundtable: Toward an International Forum: Constituting a Cosmopolitan Ethics 9:00am Human Life and Law: Autonomy, Rights, Integrity, Elizabeth Bartholet (HLS), Gaymon Bennett (ASU), Stephen Dignity Hilgartner (Cornell), Tobias Rees (McGill), Kaushik Sunder John Paul Kimes (Congregation for the Doctrine of the Faith), Rajan (Chicago), Dan Wikler (Harvard) Laurence Lwoff (Council of Europe), O. Carter Snead (Notre Dame), Mariachiara Tallachini (Piacenza), Patricia Williams 11:30am Open Discussion: Next Steps (and Responsibilities) (Columbia) SPONSORED BY: 11:00am Scientific Possibilities, Concerns, and Responsibilities George Daley (HMS), Kevin Esvelt (MIT), William Hurlbut (Stanford), Rudolf Jaenisch (MIT), Duanqing Pei (Chinese Program on Science, Center for Biology Center for Bioethics Petrie-Flom Center Institute for Global Weatherhead Center Technology & Society and Society Harvard Medical Harvard Law School Law & Policy for International Affairs Academy of Sciences), Krishanu Saha (Wisconsin-Madison) Harvard Kennedy School Arizona State University School Harvard Law School Harvard University.

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Using Web-Based Annotation Tools for Bioinformatic Analyses of Proteomics Data
Using web-based annotation tools for bioinformatic analyses of proteomics data Kasper Lage, PhD Massachusetts General Hospital Harvard Medical School the Broad Institute Overview of this session 1) Biological networks 2) Annotating genetic and proteomic data using biological networks 3) Tissue-specific networks with disease resolution 4) Emerging resources at the Broad Institute What is a biological network? Jeong et al., Nature 2001 1) Gene expression correlations 2) Protein-protein interactions 3) Co-mentioning in text D 4) Synthetic lethality 5) TF binding 6) Pathway database mining 7) Epigenetic data 8) All of the above Building a human protein-protein interaction network - InWeb Email [email protected] if you want to use the data. Lage, Karlberg et al., Nat. Biotech., 2007 Lage, Hansen et al. PNAS, 2008 Lage et al., Mol Syst Biol, 2010 Rossin et al., PLoS Genetics, 2011 Lage et al., PNAS, 2012 Social human networks D are a good model for understanding biological networks Social networks People are represented by “nodes”, work related interactions by “edges” daily weekly monthly Social networks People that work together are close to each other in the network daily weekly monthly Social networks People that work together are close to each other in the network daily weekly monthly Social networks People that work together are close to each other in the network daily weekly monthly Lone< wolf Social networks People that work together are close to each other in the network Do loci connect more than a random expectation? Quantify
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