th Conference 4 of translational medicine on pathogenesis and therapy of immune-mediated diseases Innate immunity, inflammation and human models of diseases. Auto-inflammation/Autoimmunity, Cancer and Viral Infections

March 27th - 29th, 2017 Palermo, Italy

w w w. t r a n s l a t i o n a l i m m u n o l o g y. i t preliminary program VENUE Aula Magna della Scuola Politecnica University of Palermo, Campus Viale delle Scienze - 90128 Palermo Under the patronage of

This meeting is supported by the joint Ph.D. program between UNIPA (University of Palermo) and HUNIMED (Humanitas University)

Comune di Palermo th DAY1 Monday 27 , March 2017 OPENING DAY

LUNCH SATELLITE SYMPOSIA Sponsored by BD Biosciences 12:00 APPLICATION OF ADVANCED FLOW CYTOMETRY Chair: Enrico Lugli, Humanitas Research Hospital, Milan, Italy Silvia Della Bella, University of Milan and Humanitas Research Hospital, Italy 12:10 Mario Roederer, NIAIMS, NIH, Bethesda, MD, USA Leukocyte Trafficking in Primates: More Regulation Than Green, Yellow, Red 12:55 Ido Amit, Immunology Department, Weizmann Institute of Science, Israel 13:25 The power of ONE: Immunology in the age of single cell genomics Edoardo Fiorillo, Genetic and Biomedic Research Institute (IRGB), CNR, Monserrato, Italy Immune system dissection and its genetic regulation: impact on complex diseases 13:55 Robert Balderas, Vice President, R&D at BD Biosciences, USA Integration of receptor proteome in Panel Design for HP flow

14:25 DISCUSSION PANEL

MINI SATELLITE SYMPOSIA Sponsored by Thermo Fisher Scientific DRIVING ExCELLENCE AND INNOVATION IN TAkING bIOMARkERS FROM bENCH TO bEDSIDE 15:10 Speaker: Mike Evans, Business Development Manager RNA biomarkers: Choosing the right tool for the job 15:55 Speaker: Gauri Ganpule, Associated Director Product Management - Oncology Next Generation Sequencing advances Immuno-Oncology translational research

16:40 / 17:55 MEET THE EXPERT Sponsored by Charles River CRISPR/CAS9 FOR RODENT MODELS OF HUMAN DISEASES: THE GOOD, THE bAD AND THE UGLY Speaker: Guillaume Pavlovic, Genetic Engineering and Model Validation Department, Institut Clinique de la Souris, France 18:10 OPENING CEREMONY AND WELCOME Domenico Mavilio, University of Milan and Humanitas Research Hospital, Italy Francesco Dieli, University of Palermo, Palermo, Italy 18:30 Opening Lecture TOPIC: IL-1 FAMILY CYTOKINES IN THERAPY Chair: Antonio Sica, Humanitas Research Hospital, Milan, Italy Speaker: Charles Dinarello, University of Colorado School of Medicine, Colorado, USA

19:15 OPENING RECEPTION, POSTER SESSION th DAY 2 Tuesday 28 , March 2017 AUTO-INFLAMMATION AND AUTO-IMMUNITY

9:00 Opening Lecture SOME LESSONS FROM AuTOINFLAMMATORY DISEASES Chair: Alberto Martini, G. Gaslini Institute, Genoa, Italy Speaker: Dan Kastner, NHGRI, NIH, Bethesda, MD, USA FIRST SESSION FROM AUTO-INFLAMMATION TO AUTOIMMUNITY Chairs: Richard Siegel, NIAIMS, NIH, Bethesda, MD, USA Mariana Kaplan, NIAIMS, NIH, Bethesda, MD, USA 10:00 Richard Siegel, NIAIMS, NIH, Bethesda, MD, USA 10:20 Mariana Kaplan, NIAIMS, NIH, Bethesda, MD, USA 10:40 Alberto Martini, G. Gaslini Institute, Genoa, Italy 11:00 Yenan Bryceson, Karolinska Institutet, Karolinska University Hospital Huddinge Center for Hematology and Regenerative Medicine (HERM), Huddinge, Sweden 11:20 SHORT TALk SELECTED FROM SUbMITTED AbSTRACTS 11:30 DISCUSSION PANEL

11:40 - 12:10 COFFEE BREAK & POSTER VIEW

MEET THE EXPERT 12:10 FROM PATHOGENESIS TO THERAPY OF AUTO-INFLAMMATORY DISEASES: CANAkINUMAb AND ITS CLINICAL IMPLICATION Speaker: Marco Gattorno, G. Gaslini Institute, Genoa, Italy

13:00 LUNCH & POSTER VIEW

MEET THE EXPERT Sponsored by Merck 13:50 AMNIS IMAGING FLOW CYTOMETRY: AN INNOVATIVE AND POWERFUL TOOL FOR UNCONVENTIONAL FLOW CYTOMETRY ASSAYS Speaker: Carlo Raviolo, Merck, spA SECOND SESSION FROM AUTO-INFLAMMATION TO CARDIOVASCULAR DISEASES Chairs: Manfred Boehm, Center for Molecular Medicine, NHLBI-NIH, Bethesda, USA Ivona Aksentijevich, National Human Research Genome Institute, Bethesda, USA 14:30 Manfred Boehm, Center for Molecular Medicine, NHLBI-NIH, Bethesda, USA 14:50 Ivona Aksentijevich, National Human Research Genome Institute, Bethesda, USA 15:10 Min Ae Lee-Kirsch, University Carl Gustav Carus Technische Universität Dresden, Germany 15:30 Connie Weyand, Stanford University School of Medicine, Stanford, USA 15:50 SHORT TALk SELECTED FROM SUbMITTED AbSTRACTS 16:00 DISCUSSION PANEL

16:10 - 16:40 COFFEE BREAK & POSTER VIEW THIRD SESSION AUTOINFLAMMATION TO PRIMARY IMMUNO DEFICIENCIES AT THE bORDERS WITH INFECTIONS Chairs: Anna Villa, National Research Council IRGB Institute and Humanitas Research Hospital, Milan, Italy Steven Holland, NIAIMS, NIH, Bethesda, MD, USA 16:40 Steven Holland, NIAIMS, NIH, Bethesda, MD, USA 17:00 Anna Villa, National Research Council IRGB Institute and Humanitas Research Hospital, Milan, Italy 17:20 Ridha Barbouche, Institut Pasteur de Tunis, Tunis 17:40 SHORT TALk SELECTED FROM SUbMITTED AbSTRACTS 17:50 DISCUSSION PANEL

FINAL SESSION LENTIVIRUS TECHNOLOGY IN GENE THERAPY 18:00 MEET THE EXPERT Sponsored by Miltenyi Biotec Speaker: Boro Dropulic, Lentigen Technology, Inc. a Miltenyi Biotec Company, Gaithersburg, USA 18:20-19:20 Closing Lecture Chair: Anna Villa, National Research Council IRGB Institute and Humanitas Research Hospital, Milan, Italy Speaker: Luigi Naldini, San Raffaele Institute and Telethon Insitute, Milan, Italy

20:00 SOCIAL DINNER IN DOWNTOWN PALERMO

th DAY Wednesday 29 , March 2017 3 CANCER AND VIRAL IMMUNITY

9:00 Opening Lecture TOPIC: CANCER IMMuNOLOGY Chair: Massimo Locati, University of Milan and Humanitas Research Hospital, Italy Speaker: Alberto Mantovani, HUNIMED University and Humanitas Research Hospital, Milan, Italy

FIRST SESSION INNATE IMMUNITY AND CANCER I Chairs: Raffaella Bonecchi, HUNIMED University and Humanitas Research Hospital, Milan, Italy Stefania Vetrano, HUNIMED University and Humanitas Research Hospital, Milan, Italy 10:00 Marco Cassatella, University of Verona, Italy 10:20 Gioacchino Natoli, HUNIMED University and Humanitas Research Hospital, Milan, Italy 10:40 Michele de Palma, École Polytechnique Fédérale de Lausanne (EPFL) Lausanne, Switzerland 11:00 Carola Ries, Roche Innovation Center Munich, Germany 11:20 Massimiliano Mazzone, University of Leuven, Leuven, Belgium 11:40 SHORT TALk SELECTED FROM SUbMITTED AbSTRACTS 11:50 DISCUSSION PANEL

12:00 - 12:30 COFFEE BREAK

MINI-SYMPOSIA 12:30 INNATE LYMPHOID CELLS AND TRANSLATIONAL MEDICINE Sponsored by Stemcell – Voden Chair: Massimo Locati, University of Milan, Humanitas Research Hospital, Milan, Italy Speakers: Francesco Annunziato, University of Florence, Italy Camilla Jandus, University of Lausanne, Switzerland Yanet Valdez, University of British Columbia, Vancouver, Canada

13:20 LUNCH & POSTER VIEW SECOND SESSION INNATE IMMUNITY AND CANCER II Chairs: Bruno Silva-Santos, University of Lisbona, Lisbona, Portugal Francesco Dieli, University of Palermo, Palermo, Italy 14:20 Franco Locatelli, University of Pavia, Pavia, Italy 14:40 Bruno Silva-Santos, University of Lisbona, Lisbona, Portugal 15:00 Dmitry Gabrilovich, Wistar Institute, Philadelphia, PA, USA 15:20 SHORT TALk SELECTED FROM SUbMITTED AbSTRACTS 15:30 DISCUSSION PANEL 15:40 - 16:10 COFFEE BREAK & POSTER VIEW THIRD SESSION 16:10 IN TRANSITION: FROM CANCER TO INFECTION Speakers: Elisabeth Murchison, University of Cambridge, U.K. INNATE IMMUNITY AND VIRAL INFECTIONS Chairs: Luis Montaner, Wistar Institute, Philadelphia, PA, USA Domenico Mavilio, University of Milan and Humanitas Research Hospital, Italy 16:30 Luis Montaner, Wistar Institute, Philadelphia, PA, USA 16:50 Frank Kirchhoff, Ulm University Medical Center, Ulm, Germany 17:10 David Weiner, Wistar Institute, Philadelphia, PA, USA 17:30 Miguel Lopez-Botet, University Pompeu Fabra, Barcelona, Spain 17:50 SHORT TALk SELECTED FROM SUbMITTED AbSTRACTS 18:00 DISCUSSION PANEL

18:10 Closing Lecture TOPIC: HIV-1 INFECTION Chair: Domenico Mavilio, University of Milan and Humanitas Research Hospital, Italy Speaker: Robert Gallo, Institute of Human Virology, University of Maryland School of Medicine, Co-Founder & Scientific Director, Global Virus Network, USA

SELECTED ORAL PRESENTATIONS, POSTER DISCuSSIONS AND SOCIAL EVENTS WILL BE INCLuDED IN THE FINAL VERSION OF THE PROGRAM SUPPORTED BY VENUE Aula Magna della Scuola Politecnica University of Palermo, Campus Viale delle Scienze - 90128 Palermo

SCIENTIFIC SECRETARIAT Chairman Domenico Mavilio university of Milan and Humanitas Research Hospital, Italy Local Organizer Francesco Dieli university of Palermo, Italy

Members of the Scientific Committee Ivona Aksentijevich, Manfred boehm, Marco Cassatella, Marco Gattorno, Steve Holland, Massimo Locati, Enrico Lugli, Luis Montaner, Richard Siegel, Anna Villa

w w w. t r a n s l a t i o n a l i m m u n o l o g y. i t

ORGANIZING SECRETARIAT MATERIA PRIMA T. 03631848776 - F. 03631920301 www.materia1a.it - [email protected]