KAJIMA's Engineering Approach Targeted for Large-Scale Plant

KAJIMA’s Engineering Approach targeted for Large-scale Plant Factory and Advanced Facility for Plant-Made Pharmaceuticals

November 29, 2016 Mariko Hayakumo Kajima Corporation

• Kajima Corporation Proﬁle • Main achievements on Plant Factory • 3 Component Technologies • Next Plan in North America

• Corporate Data

• Global Network

• Kajima USA overview

• Organization chart

• Engineering Target Areas

• Multiple Specialities

KAJIMA Corporation

Kajima Corporation Founded in 1840

Over 12,000 Employees Worldwide

2015 Annual Revenue of $15.8 Billion

# 9 ENR Top International Contractors

Primary Operations in Japan, Asia, US, & Europe Tokyo Headquarters

Kajima Europe LTD.(KEL) Kajima Poland Sp.z o.o(KPO) Kajima Czech Design and Construction S.R.O.(KCDC) The Austin Company Kajima Associates,Inc. Kajima Building & Tokyo KCS WEST,Inc. Design Group, Inc. Kajima U.S.A. Kajima Corporation BATSON-COOK COMPANY Headquarters (China) CO.,LTD. Hawaiian Dredging Construction,Inc. Kajima Alberici Mexico. Gurgaon Bangkok Manila Kajima Overseas Asia PTE LTD (KOA)

Jakarta

Kajima Australia

Principal Overseas Subsidiaries and Afﬁliates

We have a network of overseas subsidiaries and afﬁliates in North America, Asia and Europe providing building construction and/or real estate development business. 5

KAJIMA USA

Kajima USA Celebrating 52 Years in the US

Headquartered in Atlanta, GA

$2 Billion Average Annual Revenue

Over 1,000 Employees

10 Design, Construction, & Real Estate Companies Mitsubishi Power Systems Heavy Industrial Manufacturing Facility 6

Kajima U.S.A. Group Organization

Pharmaceutical factories Food/Cosmetic Chemical Plants

Pharmaceutical Plant factories Research laboratories

• Large-scale plant factory • Advanced Laboratory for PMPs • Case for the production of PMPs in Japan

Large-scale Plant Factory Advanced Laboratory for Plant-made Pharmaceuticals (hereinafter PMPs)

Mirai Co., Ltd.

“Mirai Tagajo greenroom”

Wolrd’s largest-scale plant factory equipped with full LED

・Renovated the electronic device factory ・Enables stable plant production with HVAC system featuring cultivation environment-simulation technology

Contents： Facility design /construction Cultivation rack system

Production scale：10000pcs/day

JA Tozai Shirakawa Mitsui Fudosan Co. “Miryoku manten vegetable house” “Kashiwa no ha 2nd green room”

Contents： Cultivation rack system Contents： Cultivation rack system Production scale：3,000pcs/day Production scale：10,000pcs/day

Others NYK Trading Corporation “Tsuruga Plant Factory”

Contents： Facility design Production scale：3,000pcs/day

Achievement for plant factory plan : Overseas Project Total 46,000pcs/day SCATIL (Hong Kong ) Contents： Facility basic design / Cultivation rack system Production scale：3,000pcs/day

KGPP (Russia ) Contents： Facility basic design Production scale：10,000pcs/day

Achievements of all 2 genetically modified plant factories in Japan

Advanced Industrial Science and Technology (AIST), Northern Advancement Center for Science & Technology Hokkaido center (NOASTEC) Closed Type Plant Production System for PMPs Green Chemical Laboratory (Design/Construction : Feb. 2007 Completion) (Design/Construction : Dec. 2012 Completion)

The most advanced system to conduct consistently the process from “Production, growth and culture of genetically modified plants” to “extraction, purification and preparation of useful substance” 20

Hokusan Co., Ltd.

“InterBerry α”

• Veterinary Medical Product to Alleviation of gingivitis for dogs made from genetic recombination strawberries ex- pressing interferon α

• The first approved pharmaceutical products made from plants themselves in the world (2013)

• Production at the closed plant factory for PMPs in AIST

• Key factors of Kajima’s Engineering • Planning technology understood plant physiology

• Facility for high-value added plants production

Key factors of Planning Facility for Kajima’s technology high-value Engineering understood added plants plant physiology production

Cultivation system plan Energy saving ・Cultivation rack plan suited for kinds of crops • Optimization of cultivation lighting ・Lighting for cultivation • HVAC plan ・Nutrient solution system • Utilization of Green energy ・Environment monitoring system • Controlled Environment system ・CO2 enrichment system • Water treatment ・Durability design etc.

Automation Hygienic management Automated • Technical consultation for daily hygienic management Material handling • Sterilization technology of cultivation space and system hydroponic system

Understanding plant physiology Utilization of plant cultivation Ex. Photosynthetic, Transpiration, environmental simulation Nutrient Physiology

Plant Scientist joins the project

Research Institute for R&D since 1949 ・Collaborative R&D ・Supports for outside organizations

Totalize cultivation process and • GMP Compliance pharmaceutical process • Cartagena Law support • Containment technology

Joint research with the leading runner on PMPs in Japan 2007-2011, 2011-2015 METI

• Project structure • Case Study

Finding Basic Design Procurement Construction Issues Planning Phase Phase Consulting Phase Phase

Kajima Engineering team Specific technical supports

K.B.D.G

Q1： We are interested in plant factory. How should we do? Which kinds of plants is it produced by plant factory?

A1： Kajima propose the various cultivable plants by the collaboration between Kajima and cultivators who have cultivation know-how (leaves, fruits and edible flowers etc.) and plant factory basic plan designed for plant species.

Q2：We would like to build the plant factory can harvest tens of thousands of lettuce per day. We would like to produce local food by using the existing area or facility.

Copyright (C) 2016 KAJIMA CORPORATION All Rights Reserved. Q2：We would like to build the plant factory can harvest tens of thousands of lettuce per day. We would like to produce local food by using the existing land.

A2： Kajima propose the eﬃcient facility plan suited for client’s requirements. It is possible for the facility design suited for the actual operation plan, estimation of production scale and also automated material handling system.

Q3：We would like to plan the cultivation facility and pharmaceutical facility for the production of plant made vaccine (PMPs).

A3： Kajima design the facility plan to utilize cultivation process and pharmaceutical process. We manage GMP compliance if it is necessary.