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HIV Drug Resistance Workshop: Basic Principles & Clinical Implications June 10–14 2008, Sitges, Spain Blank Page 11/6/08 12:31 Page 1 Prelims 19/5/08 11:19 Page Vii HIV abstracts title 12/6/08 12:21 Page 1 Abstracts presented at the XVII International HIV Drug Resistance Workshop: Basic Principles & Clinical Implications June 10–14 2008, Sitges, Spain Blank page 11/6/08 12:31 Page 1 Prelims 19/5/08 11:19 Page vii HIV DRUG RESISTANCE w o r k s h o p basic principles & clinical implications June 10-14, 2008 • Sitges, Spain ORGANIZING COMMITTEE John Mellors, Chair University of Pittsburgh, USA Douglas Richman, Co-Chair and Course Director VA San Diego Healthcare System and University of California San Diego, USA Charles Boucher Erasmus Medical Center Rotterdam and University Hospital Utrecht, the Netherlands Brendan Larder RDI, UK SCIENTIFIC COMMITTEE Lee Bacheler VircoLab, Inc, USA Ralf Bartenschlager University Heidelberg, Germany Nick Cammack Roche Palo Alto, USA François Clavel Inserm U552, France Bonaventura Clotet Fundacio IRSI Caixa, Spain John Coffin National Cancer Institute-Frederick, USA Abel De La Rosa Pharmasset, USA Matthias Gotte McGill University, Canada Robert Grant Gladstone/UCSF, USA Michael Greenberg Trimeris, Inc., USA George Hanna Bristol-Myers Squibb, USA Richard Harrigan BC Centre for Excellence in HIV/AIDS, Canada Daria Hazuda Merck Research Labs, USA Nicholas Hellmann Kleiner Perkins Caufield & Byers Walid Heneine Centers for Disease Control and Prevention, USA Kurt Hertogs Tibotec bvba, Belgium Daniel Kuritzkes Brigham and Women's Hospital, USA Susan Little University of California, San Diego, USA Stephen Locarnini VIDRL, Australia Douglas Mayers Idenix Pharmaceuticals, USA Michael Miller Gilead Sciences, USA Carlo Perno Universita Di Tor Vergata, Italy Christos Petropoulos Monogram Biosciences, USA Deenan Pillay University College London, UK Lisa Ross GlaxoSmithKline, USA Jonathan Schapiro National Hemophilia Center – Israel, Israel Raymond Schinazi Emory University/VA Medical Center, USA David Stammers University of Oxford, UK Mark Wainberg McGill University AIDS Centre, Canada Mike Westby Pfizer Global R&D, UK Andrew Zolopa Stanford University, USA ORGANIZING SECRETARIAT Informed Horizons, LLC 1631 Phoenix Boulevard, Suite 4 College Park GA 30349, USA Telephone: +1 770 997 2484 Facsimile: +1 770 997 2488 Email: [email protected] Website: www.informedhorizons.com XVII International HIV Drug Resistance Workshop: Basic Principles and Clinical Implications vii Prelims 19/5/08 11:19 Page viii Prelims 19/5/08 11:19 Page ix HIV DRUG RESISTANCE w o r k s h o p basic principles & clinical implications June 10-14, 2008 • Sitges, Spain PROGRAMME TIME TITLE PRESENTING AUTHOR ABSTRACT Tuesday, June 10, 2008 19:00-21:00 Welcome dinner: Melia Sitges Wednesday, June 11, 2008 Morning Sessions 8:30 Opening remarks and introduction of plenary John Mellors; University of Pittsburgh, USA 8:45 Diversity-generating retroelements Jeffery F Miller; UCLA School of Medicine, USA P1 RESISTANCE TO NEW ANTIVIRAL AGENTS Chairs: Douglas Richman VA San Diego Healthcare System and University of California San Diego, USA François Clavel Inserm U552, France 9:30 Potent HIV-1 entry inhibitors with a reserve Michael Kay; University of Utah School of 1 of binding energy against resistance mutations Medicine, USA 9:45 Resistance to CCR5mAb RoAb3952 is associated Andreas Jekle; Roche Palo Alto, USA 2 with a shift in binding from the extracellular domain 2 to the N terminus of CCR5 10:00 Novel resistance profile of the potent Jeffrey Meteer; University of Pittsburgh, USA 3 nucleoside analogue reverse transcriptase inhibitor 3’-azido-2’,3’-dideoxyguanosine 10:15 BREAK 10:45 Hexadecyloxypropyl tenofovir (CMX157) has Randall Lanier; Chimerix Inc., USA 4 enhanced potency in vitro against NRTI- resistant HIV relative to renofovir and a favourable preclinical profile 11:00 In vitro cross-resistance profile, antiviral activity, Robert Murphy; Northwestern University 5 safety and pharmacokinetics in HIV-1-infected Feinberg School of Medicine, USA patients of IDX899, a novel HIV-1 NNRTI with high barrier to resistance 11:15 Longitudinal analysis of resistance to the Michael Miller; Merck & Co., Inc.
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