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American Journal of Physiology American Journal of Physiology (AJP) Individual Journals (AJP) consolidated Online Print and Online Online Only Only Domestic International AJP-Regulatory, AJP-Heart AJP-Lung Cellular AJP-Cell AJP-Endocrinology AJP-Gastrointestinal Integrative and AJP-Renal Tier 1 $4,125 $5,985 $6,600 and Circulatory and Molecular Physiology and Metabolism and Liver Physiology Tier 2 5,060 6,940 7,640 Physiology Physiology Physiology Tier 3 5,805 7,820 8,560 Tiers 4 &5 Custom Custom Custom Tier 1 $780 $555 $595 $1,065 $520 $750 $555 Print Only Tier 2 930 665 705 1,280 640 895 665 Domestic International Tier 3 1,100 785 825 1,510 755 1,050 785 Tiers 1-5 $7,690 $8,460 Tiers 4 &5 Custom Custom Custom Custom Custom Custom Custom

Journal of Journal of Applied Physiology Physiological Reviews Physiology Online Print and Online Online Print and Online Online Print and Online Online Print and Online Only Domestic International Only Domestic International Only Domestic International Only Domestic International Tier 1 $1,495 $2,165 $2,355 Tier 1 $1,310 $1,905 $2,025 Tier 1 $500 $715 $765 Tier 1 $310 $455 $475 Tier 2 1,780 2,515 2,720 Tier 2 1,565 2,225 2,350 Tier 2 610 835 880 Tier 2 380 530 555 Tier 3 2,115 2,840 3,050 Tier 3 1,855 2,490 2,630 Tier 3 725 935 995 Tier 3 445 595 630 Tiers 4 &5 Custom Custom Custom Tiers 4 &5 Custom Custom Custom Tiers 4 &5 Custom Custom Custom Tiers 4 &5 Custom Custom Custom Print Only Print Only Print Only Print Only Domestic International Domestic International Domestic International Domestic International Tiers 1-5 $2,805 $3,020 Tiers 1-5 $2,455 $2,600 Tiers 1-5 $920 $980 Tiers 1-5 $585 $620

Physiological Genomics Advances in Physiology Education APS Journal Journals Digital Library Legacy Content Online Only Print Only Online Only 10 peer-reviewed original research one-time purchase per site Domestic International journals & 2 review journals Tier 1 $365 Tiers 1-5 Free Worldwide $145 $170 Online Only Online Only Tier 2 445 Tier 3 520 The Physiologist Tier 1 $8,065 Tier 1 $2,745 Tiers 4 & 5 Custom Online Only Print Only Tier 2 9,210 Tier 2 3,255 Domestic International Tier 3 10,095 Tier 3 3,865 Tiers 1-5 Free Worldwide $260 $315 Tiers 4 &5 Custom Tiers 4 &5 Custom

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Choose the journal(s) you would like to subscribe to: Available in Print & Online Check one Available Online Only AJP–Regulatory, Integrative AJP consolidated* Online Print Print & Online Physiological Genomics and Comparative Physiology* Journal of Applied Physiology Online Print Print & Online AJP–* APS Journal Legacy Content Journal of Neurophysiology Online Print Print & Online AJP–Endocrinology and Metabolism* Journals Digital Library Physiological Reviews Online Print Print & Online AJP–Gastrointestinal and Liver Physiology* Available in Print Only Physiology Online Print Print & Online AJP–Heart and Circulatory Physiology* Advances in Physiology Education AJP–Lung Cellular and Molecular Physiology* The Physiologist *AJP stands for American Journal of Physiology AJP–Renal Physiology* Please select your tier (refer to chart on reverse side) Tier 1 Tier 2 Tier 3 Tier 4 Tier 5  Check or money order enclosed+ for (Maryland Residents add 6% sales tax or give tax exempt # )  Charge my order to: VISA MasterCard AmEx Card No. Exp. Date Signature Name on Card Date Ship To: Name Title Institution Street Address City/State Zip/Postal Code Country Phone Fax Email

Mail To: American Physiological Society +All orders are payable in advance by check, money order or charge (Visa, Mastercard, or American Express). All orders c/o Customer Service must be paid in U.S. dollars, drawn on a U.S. bank. Subscriptions are sold for the calendar year, January to December. 6120 Executive Blvd., Suite 600 Rockville, MD 20852-4911 Make checks payable to: American Physiological Society PUBLICATIONS OF THE AMERICAN PHYSIOLOGICAL SOCIETY www.physiology.org

AMERICAN JOURNAL OF PHYSIOLOGY volume 310 no.2 august 2016

AMERICAN JOURNAL OF PHYSIOLOGY American Journal of Physiology (AJP) consolidated—www.physiology.org volume 310 no.2 august 2016 The consolidated American Journal of Physiology (AJP) ranks as one of the most frequently cited publications among all physiology journals listed in the Clarivate Journal Citation Reports. Published in two monthly volumes by the APS, the consolidated AJP brings you approximately 1,800 articles encompassing 17,800 pages annually. The consolidated edition of the AJP comprises the below seven highly regarded journals of the APS.

1 of 2 AJP–Cell Physiology AJP–Heart and Circulatory Physiology AJP–Renal Physiology PUBLISHED BY THE AMERICAN PHYSIOLOGICAL SOCIETY AJP–Endocrinology and Metabolism AJP–Lung Cellular and Molecular Physiology AJP–Gastrointestinal and Liver Physiology AJP–Regulatory, Integrative and Comparative Physiology 2 of 2 PUBLISHED BY THE AMERICAN PHYSIOLOGICAL SOCIETY Journal of Neurophysiology—jn.org Journal of Neurophysiology® The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the a multidisciplinary neuroscience journal membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems , imaging and mapping techniques, and behavioral analysis. Journal of Applied Physiology—jappl.physiology.org A leader in its field, the Journal of Applied Physiology publishes original papers that deal with normal or abnormalfunction in six discrete, but often Published by the American Physiological Society Volume 117 Number 4 April 2017 related, areas: 1) respiratory physiology, 2) nonrespiratory functions of the lungs, 3) environmental physiology, 4) temperature regulation, 5) exercise physiology, and 6) interdependence. Physiological Reviews—prv.org Ranked number one among physiology journals, Physiological Reviews provides state-of-the-art coverage of timely issues in the physiological and biomedical sciences. It appeals to physiologists, neuroscientists, cell biologists, biophysicists, and clinicians with special interest in pathophysiology. Topics are covered in a broad and comprehensive manner. These articles are very useful in teaching and research as they provide interesting, clearly written updates on important new developments. Physiological Genomics—physiolgenomics.org Physiological Genomics publishes the results of a wide variety of experimental and computational studies from human and model systems to link genes and pathways to physiological functions. The journal encourages the submission of research utilizing genomics, epigenomics, proteomics, metabolomics, and other systems approaches together with novel technologies linking genes to the function of complex biological pathways. Physiology—physiologyonline.org Published jointly with the International Union of Physiological Sciences, Physiology publishes invited review articles written by leaders in their fields. These articles are peer reviewed and highlight major advances in the broadly defined field of physiology. The journal also publishes shorter articles that either present important emerging topics and technologies or differing points of view. Finally, the journal highlights and briefly summarizes some of the most exciting new papers in physiology. Ranked as the number five journal in physiology, Physiology is a valuable tool for researchers, educators, and students. APS Journals Digital Library—www.the-aps.org/jdl The Journals Digital Library of the APS is a single package of the Society’s 10 peer-reviewed original research and two review journals. APS Journal Legacy Content—ajplegacy.physiology.org The APS Journal Legacy Content is available online only and can be purchased separately at a one-time charge. It is a separate program from the subscription program in that you pay once for the perpetual access to the online content from all APS journals from 1898 to 1996-1998, depending on the journal.

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