No More Cloning Around Like Many Stem Cell Pioneers, Ian Wilmut, the Creator of Dolly the Sheep, Has Jumped to an Alternative Approach
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CURRICULUM VITAE Marijo G
CURRICULUM VITAE Marijo G. Kent–First, B.A, M.S, Ph.D. CURRENT CORRESPONDING ADDRESS: BIRTH PLACE Bainbridge, GA, USA 3832 McFarlane Drive Tallahassee, FL 32303 Phone: NATIONALITY American/USA *Cell: 662-341-5243 (cell) E-mail: [email protected] Email: [email protected]+ PERSONAL and PROFESSIONAL INTERESTS: -Training of students in Basic Sciences, Anatomy, Physiology and Genetics, Veterinary and Human Medicine and Pharmacy -Maintain animals carrying rare genetic mutation(s) for use in undergraduate research projects. -Research Focus: Reproductive genetics; embryogenesis/ oxidative stress induced genomic instability and tumorigenesis - Commercial Focus: Development of novel assays and tools for cancer diagnostics. - Breed, train & show horses across multiple disciplines Philosophy: Excellence in teaching and research is best achieved through active student/mentor relationships! “The most inspirational pioneers in science are often described as being passionate about their work with a little bit of eccentricity thrown in for good measure --- Science is fun and the process of learning should be an exciting adventure for both professor and student”! EDUCATION/DEGREES/CERTIFICATIONS POST-DOCTORAL: 2014-present Certification for Online Education and Teaching at Jackson State University Jackson State University Jackson, MS. (Ms. Tamika Morehead) 1990 - 1991 Reproductive Genetics Consultant- Clinical Embryology Bourn Hall Infertility Clinic, Bourn, Cambridge, UK (Prof. R.G. Edwards) Preimplantation Genetic Diagnosis and sex selection in human embryos resulting from in vitro fertilization (IVF) 1988 - 1990 Genetic Consultant - American Breeders Service Deforest, WI (Dr. R. Walton and Dr. J. Sullivan) Preimplantation Genetic Diagnosis; Sex selection in bovine 1988 -1990 Associate Scientist -University of WI, Madison Dept. of Meat and Animal Science (Prof. -
Observation and a Numerical Study of Gravity Waves During Tropical Cyclone Ivan (2008)
Open Access Atmos. Chem. Phys., 14, 641–658, 2014 Atmospheric www.atmos-chem-phys.net/14/641/2014/ doi:10.5194/acp-14-641-2014 Chemistry © Author(s) 2014. CC Attribution 3.0 License. and Physics Observation and a numerical study of gravity waves during tropical cyclone Ivan (2008) F. Chane Ming1, C. Ibrahim1, C. Barthe1, S. Jolivet2, P. Keckhut3, Y.-A. Liou4, and Y. Kuleshov5,6 1Université de la Réunion, Laboratoire de l’Atmosphère et des Cyclones, UMR8105, CNRS-Météo France-Université, La Réunion, France 2Singapore Delft Water Alliance, National University of Singapore, Singapore, Singapore 3Laboratoire Atmosphères, Milieux, Observations Spatiales, UMR8190, Institut Pierre-Simon Laplace, Université Versailles-Saint Quentin, Guyancourt, France 4Center for Space and Remote Sensing Research, National Central University, Chung-Li 3200, Taiwan 5National Climate Centre, Bureau of Meteorology, Melbourne, Australia 6School of Mathematical and Geospatial Sciences, Royal Melbourne Institute of Technology (RMIT) University, Melbourne, Australia Correspondence to: F. Chane Ming ([email protected]) Received: 3 December 2012 – Published in Atmos. Chem. Phys. Discuss.: 24 April 2013 Revised: 21 November 2013 – Accepted: 2 December 2013 – Published: 22 January 2014 Abstract. Gravity waves (GWs) with horizontal wavelengths ber 1 vortex Rossby wave is suggested as a source of domi- of 32–2000 km are investigated during tropical cyclone (TC) nant inertia GW with horizontal wavelengths of 400–800 km, Ivan (2008) in the southwest Indian Ocean in the upper tropo- while shorter scale modes (100–200 km) located at northeast sphere (UT) and the lower stratosphere (LS) using observa- and southeast of the TC could be attributed to strong local- tional data sets, radiosonde and GPS radio occultation data, ized convection in spiral bands resulting from wave number 2 ECMWF analyses and simulations of the French numerical vortex Rossby waves. -
The Effect of Interspecific Oocytes on Demethylation of Sperm DNA
The effect of interspecific oocytes on demethylation of sperm DNA Nathalie Beaujean*†‡, Jane E. Taylor*, Michelle McGarry*, John O. Gardner*, Ian Wilmut*, Pasqualino Loi§, Grazyna Ptak§, Cesare Galli¶, Giovanna Lazzari¶, Adrian Birdʈ, Lorraine E. Young**††, and Richard R. Meehan†‡‡ *Division of Gene Expression and Development, Roslin Institute, Roslin EH25 9PS, United Kingdom; †Department of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, United Kingdom; §Department of Comparative Biomedical Sciences, Teramo University, Teramo 64100, Italy; ¶Laboratorio di Tecnologie della Riproduzione, Istituto Sperimentale Italiano Lazzaro Spallanzani, CIZ srl, Via Porcellasco 7͞f, 26100 Cremona, Italy; ʈWellcome Trust Centre for Cell Biology, University of Edinburgh, The King’s Buildings, Edinburgh EH9 3JR, United Kingdom; **Institute of Genetics and Division of Obstetrics and Gynaecology, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom; and ‡‡Human Genome Unit, Medical Research Council, Western General Hospital, Crewe Road, Edinburgh EH4 9XU, United Kingdom Edited by Rudolf Jaenisch, Whitehead Institute for Biomedical Research, Cambridge, MA, and approved April 7, 2004 (received for review February 2, 2004) In contrast to mice, in sheep no genome-wide demethylation of the Materials and Methods paternal genome occurs within the first postfertilization cell cycle. All animal procedures were under strict accordance with U.K. This difference could be due either to an absence of a sheep Home Office regulations and within a project license issued demethylase activity that is present in mouse ooplasm or to an under the Animal (Scientific Procedures) Act of 1986. increased protection of methylated cytosine residues in sheep sperm. -
The Relative Value of Alcohol May Be Encoded by Discrete Regions of the Brain, According to a Study of 24 Men Published This Week in Neuropsychopharmacology
PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY (http://www.nature.com/npp) This press release is copyrighted to the journal Neuropsychopharmacology. Its use is granted only for journalists and news media receiving it directly from the Nature Publishing Group. *** PLEASE DO NOT REDISTRIBUTE THIS DOCUMENT *** EMBARGO: 1500 London time (GMT) / 1000 US Eastern Time Monday 03 March 2014 0000 Japanese time / 0200 Australian Eastern Time Tuesday 04 March 2014 Wire services’ stories must always carry the embargo time at the head of each item, and may not be sent out more than 24 hours before that time. Solely for the purpose of soliciting informed comment on this paper, you may show it to independent specialists - but you must ensure in advance that they understand and accept the embargo conditions. This press release contains: • Summaries of newsworthy papers: Brain changes in young smokers *PODCAST* To drink or not to drink? *PODCAST* • Geographical listing of authors PDFs of the papers mentioned on this release can be found in the Academic Journals section of the press site: http://press.nature.com Warning: This document, and the papers to which it refers, may contain sensitive or confidential information not yet disclosed to the public. Using, sharing or disclosing this information to others in connection with securities dealing or trading may be a violation of insider trading under the laws of several countries, including, but not limited to, the UK Financial Services and Markets Act 2000 and the US Securities Exchange Act of 1934, each of which may be subject to penalties and imprisonment. PICTURES: While we are happy for images from Neuropsychopharmacology to be reproduced for the purposes of contemporaneous news reporting, you must also seek permission from the copyright holder (if named) or author of the research paper in question (if not). -
Dolly the Sheep – the First Cloned Adult Animal
DOLLY THE SHEEP – THE FIRST CLONED ADULT ANIMAL NEW TECHNOLOGY FOR IMPROVING LIVESTOCK From Squidonius via Wikimedia Commons In 1996, University of Edinburgh scientists celebrated the birth of Dolly the Sheep, the first mammal to be cloned using SCNT cloning is the only technology adult somatic cells. The Edinburgh team’s success followed available that enables generation of 99.8% its improvements to the single cell nuclear transfer (SCNT) genetically identical offspring from selected technique used in the cloning process. individuals of adult animals (including sterilized animals). As such, it is being Dolly became a scientific icon recognised worldwide and exploited as an efficient multiplication tool SCNT technology has spread around the world and has been to support specific breeding strategies of used to clone multiple farm animals. farm animals with exceptionally high genetic The cloning of livestock enables growing large quantities of value. the most productive, disease resistant animals, thus providing more food and other animal products. Sir Ian Wilmut (Inaugural Director of MRC Centre for Regeneration and Professor at CMVM, UoE) and colleagues worked on methods to create genetically improved livestock by manipulation of stem cells using nuclear transfer. Their research optimised interactions between the donor nucleus and the recipient cytoplasm at the time of fusion and during the first cell cycle. Nuclear donor cells were held in mitosis before being released and used as they were expected to be passing through G1 phase. CLONING IN COMMERCE, CONSERVATION OF AGRICULTURE AND PRESERVATION ANIMAL BREEDS OF LIVESTOCK DIVERSITY Cloning has been used to conserve several animal breeds in the recent past. -
Antidepressants During Pregnancy and Fetal Development
PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY (http://www.nature.com/npp) This press release is copyrighted to the journal Neuropsychopharmacology. Its use is granted only for journalists and news media receiving it directly from the Nature Publishing Group. *** PLEASE DO NOT REDISTRIBUTE THIS DOCUMENT *** EMBARGO: 1500 London time (BST) / 1000 US Eastern Time / 2300 Japanese time Monday 19 May 2014 0000 Australian Eastern Time Tuesday 20 May 2014 Wire services’ stories must always carry the embargo time at the head of each item, and may not be sent out more than 24 hours before that time. Solely for the purpose of soliciting informed comment on this paper, you may show it to independent specialists - but you must ensure in advance that they understand and accept the embargo conditions. A PDF of the paper mentioned on this release can be found in the Academic Journals section of the press site: http://press.nature.com Warning: This document, and the papers to which it refers, may contain sensitive or confidential information not yet disclosed to the public. Using, sharing or disclosing this information to others in connection with securities dealing or trading may be a violation of insider trading under the laws of several countries, including, but not limited to, the UK Financial Services and Markets Act 2000 and the US Securities Exchange Act of 1934, each of which may be subject to penalties and imprisonment. PICTURES: While we are happy for images from Neuropsychopharmacology to be reproduced for the purposes of contemporaneous news reporting, you must also seek permission from the copyright holder (if named) or author of the research paper in question (if not). -
Advertising (PDF)
Edited by John Cairns, Cold Spring Harbor Laboratory; Gunther S. Stent, University of California, Berkeley; James D. Watson, Harvard University his landmark collection of essays, written by pioneers in the field of molecular biology, was first published T in 1966 as a 60th birthday tribute to Max Delbrück, a formative influence on many of today’s leading sci- entists. The book served as a valuable historical record as well as a remarkable portrait of a small, pioneering, close- knit scientific community that focused intensely on the most important questions in biology. This centennial edi- tion reflects a more personal side of Delbrück, and includes a series of photographs from his family’s albums. “Delbrück had been a kind of Gandhi of biology...It was his extraordinary personality that made him the spiritu- al force which affected the scientific and personal lives of so many people.” —Gunther S. Stent 2007, 394 pp., illus., timeline, photo gallery Hardcover $29 ISBN 978-087969800-3 CONTENTS Note from the Publisher The Injection of DNA into Cells Bacterial Conjugation Quantitatitve Tumor Virology Preface to the First Edition by Phage Elie L. Wollman H. Rubin John Cairns, Gunther S. Stent, James A.D. Hershey Story and Structure of the The Natural Selection Theory D. Watson Transfer of Parental Material to λ Transducing Phage of Antibody Formation; Ten Preface to the Expanded Edition Progeny J. Weigle Years Later John Cairns Lloyd M. Kozloff V. DNA Niels K. Jerne Electron Microscopy of Developing Growing Up in the Phage Group Cybernetics of the Insect I. ORIGINS OF MOLECULAR Optomotor Response BIOLOGY Bacteriophage J.D. -
Edit Summer 2007
60282_Edit_Summer07 2/5/07 02:01 Page 1 The University of Edinburgh INCLUDING BILLET & GENERAL COUNCIL PAPERS SUMMER 07 Zhong Nanshan honoured Zhong Nanshan, who first identified SARS, received an honorary degree at a ceremony celebrating Edinburgh’s Chinese links ALSO INSIDE Edinburgh is to play host to the first British centre for human and avian flu research, while the Reid Concert Hall Museum will house a unique clarinet collection 60282_Edit_Summer07 2/5/07 02:01 Page 2 60282_Edit_Summer07 2/5/07 09:35 Page 3 Contents 16xx Foreword Welcome to the Summer 2007 edition of Edit, and many thanks to everyone who contacted us with such positive feedback about our new design. A recent ceremony in Beijing celebrated the University’s links with China and saw Professor 18 Zhong Nanshan receiving an honorary degree; Edit takes a closer look at our connections – historical and present-day – to that country (page 14). The discovery of H5N1 on a turkey farm in Norfolk earlier this year meant avian flu once 14 20 again became headline news. Robert Tomlinson reports on plans to establish a cutting-edge centre at the University to research the virus Features (page 16). The focus of our third feature is the Shackleton 14 Past, Present and Future Bequest, an amazing collection of clarinets Developing links between China and Edinburgh. recently bequeathed to the University that will be housed in the Reid Concert Hall Museum 16 From Headline to Laboratory (page 20). Edinburgh takes lead in Britain’s fight against avian flu. Anne Borthwick 20 Art meets Science Editor The remarkable musical legacy of the paleoclimatologist Editor who championed the clarinet. -
Laser Interferometer Space Antenna What Is LISA?
Volume 11 number 4 2003 FALL Quarter A FLIGHT PROGRAMS AND PROJECTS DIRECTORATE QUARTERLY PUBLICATION A Newsletter Published for Code 400 Employees INSIDE Laser Interferometer Space Antenna THIS What is LISA? ISSUE: How did the Universe begin? Does time have a beginning and an end? Does What is LISA? Page 1 space have edges? These are the questions we've struggled to answer for cen- Solar Dynamic Observatory Page 1 turies. Science and technology have now reached the point where answers to these questions are finally within our grasp. The Laser Interferometer Space Message From The Director Of Page 2 Antenna (LISA) may supply some of these answers as the mission studies Peer Award Ceremony & Picnic Page 2 the mergers of supermassive black holes, tests Einstein's Theory of General Tintypes Page 3 Relativity, probes the early Universe, and searches for gravitational waves—— its primary objective. Feedback Page 3 As the first dedicated space-based gravitational wave observatory, LISA will Technology Corner Page 6 detect waves generated by binaries within our Galaxy (the Milky Way) and Quotes of the Quarter Page 7 by massive black holes in distant galaxies. LISA will use an advanced system of laser interferometry for directly detecting and measuring them. This OBPR Free-Flyer Page 10 Best of the Best Page 12 (LISA Continued on page 4) The English Language Page 13 Peer Awards Page 14 Living with a Star Program – NASA Honor Awards Page 16 Solar Dynamics Observatory TCP Social News Page 19 Developing an understanding of the Sun took on a renewed sense of ur- Cultural Tidbits Page 19 gency during late October/early November. -
Guide to Biotechnology 2008
guide to biotechnology 2008 research & development health bioethics innovate industrial & environmental food & agriculture biodefense Biotechnology Industry Organization 1201 Maryland Avenue, SW imagine Suite 900 Washington, DC 20024 intellectual property 202.962.9200 (phone) 202.488.6301 (fax) bio.org inform bio.org The Guide to Biotechnology is compiled by the Biotechnology Industry Organization (BIO) Editors Roxanna Guilford-Blake Debbie Strickland Contributors BIO Staff table of Contents Biotechnology: A Collection of Technologies 1 Regenerative Medicine ................................................. 36 What Is Biotechnology? .................................................. 1 Vaccines ....................................................................... 37 Cells and Biological Molecules ........................................ 1 Plant-Made Pharmaceuticals ........................................ 37 Therapeutic Development Overview .............................. 38 Biotechnology Industry Facts 2 Market Capitalization, 1994–2006 .................................. 3 Agricultural Production Applications 41 U.S. Biotech Industry Statistics: 1995–2006 ................... 3 Crop Biotechnology ...................................................... 41 U.S. Public Companies by Region, 2006 ........................ 4 Forest Biotechnology .................................................... 44 Total Financing, 1998–2007 (in billions of U.S. dollars) .... 4 Animal Biotechnology ................................................... 45 Biotech -
Evolution of Multiscale Vortices in the Development of Hurricane Dolly (2008)
JANUARY 2011 F A N G A N D Z H A N G 103 Evolution of Multiscale Vortices in the Development of Hurricane Dolly (2008) JUAN FANG Key Laboratory of Mesoscale Severe Weather (MOE), Department of Atmospheric Sciences, Nanjing University, Nanjing, China FUQING ZHANG Department of Meteorology, The Pennsylvania State University, University Park, Pennsylvania (Manuscript received 6 April 2010, in final form 6 July 2010) ABSTRACT As a follow-up to a previously published article on the initial development and genesis of Hurricane Dolly (2008), this study further examines the evolution of, and interactions among, multiscale vortices ranging from the system-scale main vortex (L . 150 km) to the intermediate-scale cloud clusters (50 km , L , 150 km) and individual vorticity-rich convective cells (L , 50 km). It is found that there are apparent self-similarities among these vortices at different scales, each of which may undergo several cycles of alternating accumulation and release of convective available potential energy. Enhanced surface fluxes below individual cyclonic vortices at each scale contribute to the sustainment and reinvigoration of moist convection that in turn contributes to the maintenance and upscale growth of these vortices. Spectral analysis of horizontal divergence and relative vorticity further suggests that the cloud-cluster-scale and system-scale vortices are predominantly balanced while the individual convective vortices are largely unbalanced. The vorticity and energy produced by these individual vorticity-rich convective cells first saturate at convective scales that are subsequently transferred to larger scales. The sum of the diabatic heating released from these convective cells may be regarded as a persistent forcing on the quasi-balanced system-scale vortex. -
Development of Transgenic Livestock with Reduced Myostatin
DEVELOPMENT OF TRANSGENIC LIVESTOCK WITH REDUCED MYOSTATIN EXPRESSION USING RNA INTERFERENCE A Dissertation by KIMBERLY JEAN TESSANNE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY December 2009 Major Subject: Veterinary Physiology DEVELOPMENT OF TRANSGENIC LIVESTOCK WITH REDUCED MYOSTATIN EXPRESSION USING RNA INTERFERENCE A Dissertation by KIMBERLY JEAN TESSANNE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved by: Chair of Committee, Mark Westhusin Committee Members, Charles Long Thomas Spencer Nancy Ing Head of Department, Glen Laine December 2009 Major Subject: Veterinary Physiology iii ABSTRACT Development of Transgenic Livestock with Reduced Myostatin Expression Using RNA Interference. (December 2009) Kimberly Jean Tessanne, B.S., The Ohio State University; M.S., University of Wisconsin-Madison Chair of Advisory Committee: Dr. Mark Westhusin RNA interference (RNAi) is a means of regulating gene expression by targeting mRNA in a sequence-specific manner for degradation or translational inhibition. Short hairpin RNAs (shRNAs) and short interfering RNAs (siRNAs) have been extensively employed for manipulating gene expression in a wide range of species. The goal for this research was to produce transgenic livestock in which myostatin, a negative regulator of muscle growth, has been targeted for silencing by RNAi. This would demonstrate the utility of RNAi for reducing gene expression in large animal species. To successfully target the myostatin gene for reduction, siRNAs were designed to target the both the bovine and caprine myostatin mRNA sequence.