Preventing the next Pandemic: Vaccine Diplomacy in a time of Anti-Science
Peter Hotez MD PhD
Texas Children’s Hospital Endowed Chair in Tropical Pediatrics
Dean, National School of Tropical Medicine at Baylor College of Medicine
University Professor, Baylor University
Hagler Institute of Advanced Studies, Texas A&M University @PeterHotez
1 Under 5 Child Deaths 2000-2017
GBD 2017 Sebastiao Salgado
2000 2017
‐ Measles 478,727 ‐ Measles 83,438 (-83%) ‐ Pertussis 138,048 ‐ Pertussis 86,091 (-38%) ‐ Tetanus 105,333 ‐ Tetanus 18,623 (-82%) ‐ H. flu 86,104 ‐ H.flu 36,185 (-58%) ‐ Diphtheria 10,413 ‐ Diphtheria 2,914 (-72%)
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xxx00.#####.ppt 5/7/2020 1:49:32 PM Incidence of Hib in USA
3 Global Elimination of Polio & Measles
4 New Global Anthropocene “Hot Zones” of Vaccine- Preventable & Neglected Tropical Diseases NTDs Where political instability combines with climate change, urbanization, deforestation, or antiscience
Texas &Gulf Arabian Coast Peninsula China and Philippines Central Africa’s Latin Un-Wars America
5 War, Political Collapse, Climate Change, Urbanization • Arabian Peninsula • Venezuela
6 War, Political Collapse, Climate Change, Urbanization
• Africa Un-Wars • Texas + Gulf Coast
7 SHIFTING POVERTY: “Blue Marble Health”
• Neglected diseases of the poor living amidst wealth • A new framework for global science policy and the poverty-related diseases
8 COVID19 and the G20 Nations
• 2-3 million cases • United States • Spain • Italy • France • Germany • UK • China • Turkey
9 Tissue Expression of ACE2: Heart, Lung, Adipose, Gastrointestinal Tract
https://medium.com/@yuanhe716/tissue-specific-expression-and-genetic- regulation-of-sars-cov-2-receptors-ace2-and-tmprss2-d75d76bf45fb Page 10
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xxx00.#####.ppt 5/7/2020 1:49:33 PM Texas Children’s Hospital Center for Vaccine Development
12 Texas Children’s CVD
• Low Cost • Our Portfolio • Global Health Vaccines • Schistosomiasis • Hookworm • Recombinant protein vaccines • Onchocerciasis • Technology transfer to LMICs • Leishmaniasis • Building vaccine development • Chagas disease capacity in LMICs • Coronavirus infections • SARS and SARS 2 • MERS
13 COVID-19 in Latin America, India, Africa
14 Global Coronavirus Vaccine Initiative
15 Vaccine Diplomacy
16 Roll of Antiscience
17 The Rise of Antiscience WHO and “Vaccine Hesitancy”
80,000 measles cases 2018, >100,000 measles cases 2019
18 20 Years of ‘Vaccine Hesitancy’ 1998-2018
19 TEXAS NON-MEDICAL VACCINE EXEMPTIONS (2003-2019)
64,176
56,738 52,756
44,716 40,997 38,197 32,616 28,432 22,910 19,050
12,633 9,606 10,404 2,314 2,722 6,991
2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 to to to to to to to to to to to to to to to to 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019
20 Heat map of counties with >400 kindergarteners with NMEs in 2016 to 2017
Vaccine Hesitancy in USA
Olive JK, Hotez PJ, Damania A, Nolan MS (2018) Correction: The state of the antivaccine movement in the United States: A focused examination of 21 nonmedical exemptions in states and counties. PLOS Medicine 15(7): e1002616. The Antivax 4-Headed Monster: 1) The Media, 2) The Political Machine, 3) Deliberate Predation, 4) War on Women
22 Vaccine Scientist, Pediatrician, Autism Dad
23 Science and Public Engagement
24 Epic Struggle
Mass Treatment, 21st Century Forces Vaccines & Biologicals, Poverty, Climate Change, Vector Control War, Political Collapse, Technologies Urbanization, Antiscience
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