Was Marketed and Are Still Occumng. 168' 1699 172, 173, 175, 177-182, 185 Meprobamate Has Been Shown to Pro- 176
40 H. ISBELL & T. L. CHRUSCIEL CARBAMIC ACID ESTERS OF GLYCOLS Of the drugs listed in Table VI, carisoprodol 168. Bulla, J. D., Ewing, J. A. & Buffaloe, W. J. (1959) (S 103), emylcamate (S 104), mebutamate (S 107) Amer. Practit., 10, 1961 (Further controlled and phenprobamate (S 110) are not used primarily studies of meprobamate) as central nervous system depressants but are 169. Czerwenka-Wenkstetten, H., Hofmann, G. & recommended either for hypertension (S 107) or as Kryspin-Exner, K. (1965) Wien. med. Wschr., 115, 1012-1016 (Tranquillizersucht und Miss- " muscle relaxants " (S 103, S 104 and S 110). Some brauch) newly introduced drugs, buramate (S 102) and 170. Domino, E. F. (1965) In: DiPalma, J. R., ed., pentabamate (S 109), have been marketed as " tran- Drill's pharmacology in medicine, 3rd ed., quillizers" and hexapropymate (S 105) and oxy- pp. 356-364, McGraw-Hill, New York (Chap- fenamate (S 106) are used as sedatives. All these are ter 24: Psychosedative drugs. II. Meprobamnate, weak drugs and have not been abused or shown to chlordiazepoxide and miscellaneous agents) have abuse potential in animal or human experi- 171. Essig, C. F. (1958) Arch. Neurol. Psychiat. (Chic.), ments. 80, 414-417 (Withdrawal convulsions in dog Tybamate (S 111) used as a sedative has had an following chronic meprobamate intoxication) especially good animal and experimental work-up 172. Essig, C. F. & Ainslie, J. D. (1957) J. Amer. med. for abuse potential. 167, 170, 174, 187 It appears to be a Ass., 164, 1382 (Addiction to meprobamate) very weak, short-acting drug of no or very low 173.
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