Excitatory synapse

Vti1a

β Synptop SCAMP brevin hysin ptot Synaptic Syna mGluR Actin vesicle Synptogyrin Synaptotagmin Gi/o SV2 (2A,2B,2

PRA1 Synapsin SVOSSV C

α OPO ) PRA1 A/3B P WNT Fz R 5/3A/3B/3C

Rab3 CSP Bassoon Piccolo Rab AXIN RIM Early endosome APC APC β Cat GSK3 β MINT Velis Synapto MUNC13MU N brevin 2+ Clathrin Ca 2+ brevin Ca CASK napto Sy SyntaxinSySSynt axin SyntaxinSSyntaxin ACh R MUNC18 SNAP25 SNAP25 Ca 2+ Neurotransmitters LAR CN R SynCam nCadherin NetrinG EphrinA EphrinB Neurexin Ca 2+ channel Ca 2+ channelnnel

NGL CN R EphA EphB

NMDA R AMPAA R Kainate R mGluR SynCam LRRTM nCadherin Ca 2+2+

Neuroligin Ub CaM CaM AKAP79/150 Src MaGUK Ub Tiam Ubb AKAP79/150 PSD95 Kalirin7 Syndecan Calcineurin Src PKAA Calcineurin ArcArc UbU Spectrin Src PKAA Calcineurin PSD95 PSD95 Syntenin Ub

Src SynGap PP1 2+ Ca Homer GKAP/ Ephexin1 Vav2 SAPAP Homer

p190RhoGAP BetaPIX CaMKI CaMKK NFAT RASGRF ProSAP/Shank

Cortacin GTPP GDPDP Rho Rho Kalirin7 CaMKII Ras Ras RAF Actin GDPG GTPG GTPP MEK Rac Rac NFκB GDPG ERK

Axonal Actin Spinogenesis Synapse development, Neuronal Receptor Synaptic guidance reorganization function, and plasticity survival trafficking signaling

Discover more at abcam.com/biochemicals

Produced in collaboration with Paul L. Greer, Ph.D., Harvard Medical School Copyright © 2012 Abcam, All Rights Reserved. Discover more Excitatory synapse related products related synapse Excitatory

Featured products mGlu AAgonists Kit (S)-MCPG Group I / II mGlu antagonist GroupI/IImGluantagonist (S)-MCPG mGlu LY 367385 P LY 341495 Selective groupImGluagonist (S)-3,5-DHPG EndogenousmGlu Cinnabarinic acid SelectivemGlu (R,S)-CHPG SelectivegroupIIImGlu agonist L-AP4 mGlu AMN082 dihydrochloride Glutamate: mGlu Endogenousionotropic /nicotinicantagonist;watersoluble Kynurenic acidsodiumsalt Excitotoxicagonist Ibotenic acid L DL Glutamate: broadspectrum/non-selective Competitivenicotinicacetylcholinereceptor(nAChR) antago Vecuronium bromide AChreceptorantagonist (+)-Tubocurarine Selective PNU 282987 Methyllycaconitine citrate α Potentnicotinicagonist (±)-Anatoxin A fumarate Nicotinic SelectiveM Pirenzepine dihydrochloride Muscarinicreceptorantagonist 4-DAMP Endogenousneurotransmitteractiveatacetylcholinerecept Acetylcholine Chloride Muscarinic Product Biological description Purity Purity Biologicaldescription Product Guaae xiaoynuornmte Excitatoryneurotransmitter -Glutamate Bnaooi Subtype-selective -Bungarotoxin A4 ra pcrmguaaeatgns Broadspectrumglutamateantagonist -AP4

at abcam.com/biochemicals at World exclusive!(ab120687) Novel, selective,cellmembranepermeable clathrin Pitstop 2™clathrininhibitor- Interferes withreceptor mediatedendocytosis,entry amphiphysin association ofclathrinterminaldomain). inhibitor. Competitivelyinhibitsclathrinterminal of HIVandsynaptic vesiclerecycling. domain toselectivelyinhibitclathrin mediated endocytosis (IC

α -ioii eetratgns 9%ab12007 >98% 7-nicotinic receptorantagonist otent, selective group II antagonist. Group III antagonist >98% at higher concentrations olcino gnssadmdltr o ag fml eetrsbye - collection of 7 agonists and modulators for a range of mGlu receptor subtypes 1 7 50 naoit >9 ab1200 >99% a antagonist

gns >9 ab12 >99% agonist α = 12 Ah gns >9 ab120558 >99% 7 nAChRagonist 1 eetratgns 9%ab120153 >99% receptor antagonist 5 gns >8 ab120039 >98% agonist α 4 Ah naoit >9 ab120542 >99% 7 nAChRantagonist μ eetv gns >8 ab120506 >98% selective agonist M forinhibitionof

9%ab120041 >98% 9%ab120002 >99% >8 ab120059 >98% >9 ab120049 >99% >8 ab120144 >98% >9 ab120073 >99% 9%ab120013 >98%

9%ab120007 >99% 9%ab120001 >99% r -ab120469 - ors it ab120536 - nist 9%ab120256 >99%

from AbcamBiochemicals Product code

ab120199 ab120321 RuBi-nicotine (ab120450) andRuBi-AP (ab120410) Other cagedcompounds includeRuBi-GABA (ab120409), photoactivation ofneuronal dendritesandcircuits. Can beusedat lowconcentrations.Enables Releases glutamateafter one-ortwo-photonexcitation. Fastuncagingspeeds-singlephotochemical step • NoneedforharmfulUVlightorexpensivequartzoptics • Activatedbyvisiblewavelengthsoflight • light-sensitive, RuBi-Glutamate: Anovel caged ligand(ab120408) 0011 67 2 7-Chlorokynurenic acid sodium salt NMDA receptor glycine site antagonist; water soluble NMDA receptorglycinesiteantagonist;watersoluble 7-Chlorokynurenic acidsodiumsalt NMDA glutamatesiteantagonist D-AP5 Glutamate: NMDA mGlu YM 202074 Potent,selectivemGlu MPEP hydrochloride mGlu MMPIP mGlu AAntagonists Kit collectionof6antagonistsformGlureceptorsubtypes Glutamate: mGlu SNX 482 R-TypeSNX 482 Ca ω ω Calcium channel AMPANBQX disodiumsalt /kainateantagonist(watersoluble) Prototypickainatereceptor agonist Kainic acid A collectionof8agonists,antagonistsandpotentiators Ionotropic Agonists Kit Non-competitive AMPAGYKI 53655hydrochloride /kainatereceptorantagonist AMPACNQX disodiumsalt /kainateantagonist(watersoluble) AMPA (S)-AMPA agonist Glutamate: AMPA&Kainate GluN2D(formerlyNR2D)antagonist,withsomesubuni UBP141 Excitotoxicaminoacid NMDA Non-competitiveNMDA antagonist (+)-MK 801maleate 5,7-Dichlorokynurenic acid sodium salt NMDA receptorglycinesiteantagonist;watersoluble PotentcompetitiveNMDA antagonist (R)-CPPene eaai yrclrd L-typeCa Verapamil hydrochloride Product Biological description Purity Product Purity Biologicaldescription Product KiaeadND eetr. KainateandNMDA receptors. CntxnGI Ca -Conotoxin GVIA Ca -Agatoxin IVA

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2+ 2+ hne lce Ntp) 9%ab120215 >96% channel blocker(Ntype) ab120210 >95% channel blocker(P andQ type) 1 7

naoit >8 ab1202 >98% antagonist ab120245 >98% allosteric antagonist

2+ 2+ hne lce >9 ab120140 >99% channel blocker (Ca

v .)canlbokr 9%ab120259 >96% 2.3) channelblocker 5 naoit 9%ab120008 >99% antagonist CompatiblewithGFP-based tagsandother • Concentration requireddoesnotinterferewith • seenatindividual synapticlevel Resolution • substrate forthesynapticvesiclemonoamine transporter. Fluorecsent falseneurotransmitter(FFN) actsasa efficient opticaltracerofdopamine(ab120331) Fluorescent falseneurotransmitter -highly 9%ab120005 >98% optical probes normal synapticfunction ab120323 - >8 ab120052 >98% 9%ab120100 >99% >9 ab120003 >99%

>8 ab120232 >98% 9%ab120027 >99% >8 ab120046 >98% ab120044 >99% eetvt >8 ab120193 >98% t selectivity at AMPA,

-ab120322 - >9 ab120490 >99% 9%ab120254 >99% 9%ab120255 >99% code 93

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