GTL PI Meeting 2009 Abstracts
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Jay D Keasling
Jay D Keasling Office Address Joint BioEnergy Institute 5885 Hollis Street, Fourth Floor Emeryville, CA 94608 Phone: (510) 495-2620 FAX: (510) 495-2630 E-mail: [email protected], [email protected] Education Postdoctorate, Biochemistry, 1991-1992, Stanford University Ph.D., Chemical Engineering, 1991, University of Michigan M.S., Chemical Engineering, 1988, University of Michigan B.S., Chemistry and Biology, 1986, University of Nebraska, Lincoln Positions Current positions 2004-Present Professor, Department of Bioengineering, University of California, Berkeley, Berkeley, CA 2001-Present Professor, Department of Chemical & Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 2006-Present Senior Faculty Scientist, Biological Sciences & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 2007-Present Chief Executive Officer, Joint BioEnergy Institute (JBEI), Emeryville, CA 2017-Present Chief Science and Technology Officer for Biosciences, Lawrence Berkeley National Laboratory, Berkeley, CA 2013-Present Investigator, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark 2012-Present Sydney Brenner Visiting Professor, National University of Singapore, Singapore 2017-Present Distinguished Visiting Professor, Shenzhen Institutes for Advanced Technologies, Shenzhen, China Previous positions 2010-2017 Associate Laboratory Director for Biosciences, Lawrence Berkeley National Laboratory, Berkeley, CA 2006-2016 Director, Synthetic Biology Engineering Research Center (Synberc), -
(Synthetic) Biology
Future Directions in Engineering Biology Berkeley, California | April 4-5, 2011 Workshop Co-Chairs Adam Arkin | Douglas Clark | Matthew Tirrell University of California, Berkeley Table of Contents I. EXECUTIVE SUMMARY .................................................................................................................... 3 II. OBJECTIVES OF THE WORKSHOP ................................................................................................... 4 III. STRUCTURE OF THE WORKSHOP .................................................................................................. 4 IV. MAJOR POINTS FROM THE FIVE SESSIONS ................................................................................... 5 1. Chemical Synthesis and Production .................................................................................. 5 2. Biological Design and Assembly ......................................................................................... 8 3. Biological Systems Modeling .............................................................................................. 9 4. Tissue Engineering and Biohybrid Systems ...................................................................... 11 5. Energy, Agriculture, Environment ..................................................................................... 12 VI. MAJOR POINTS FROM THE CONCLUDING DISCUSSION SESSION ................................................. 13 VII. MAJOR POINTS ADDRESSED POST-WORKSHOP ......................................................................... -
Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases
International Journal of Molecular Sciences Review Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases Emma L. Carroll 1,†, Mariarca Bailo 2,†, James A. Reihill 1 , Anne Crilly 2 , John C. Lockhart 2, Gary J. Litherland 2, Fionnuala T. Lundy 3 , Lorcan P. McGarvey 3, Mark A. Hollywood 4 and S. Lorraine Martin 1,* 1 School of Pharmacy, Queen’s University, Belfast BT9 7BL, UK; [email protected] (E.L.C.); [email protected] (J.A.R.) 2 Institute for Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, Paisley PA1 2BE, UK; [email protected] (M.B.); [email protected] (A.C.); [email protected] (J.C.L.); [email protected] (G.J.L.) 3 Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast BT9 7BL, UK; [email protected] (F.T.L.); [email protected] (L.P.M.) 4 Smooth Muscle Research Centre, Dundalk Institute of Technology, A91 HRK2 Dundalk, Ireland; [email protected] * Correspondence: [email protected] † These authors contributed equally to this work. Abstract: Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate specificities for the basic residues, lysine and arginine, in the P1 position. Whilst initially perceived as soluble enzymes that are extracellularly secreted, a number of novel TLPs that are anchored in the cell membrane have since been discovered. Muco-obstructive lung diseases (MucOLDs) are Citation: Carroll, E.L.; Bailo, M.; characterised by the accumulation of hyper-concentrated mucus in the small airways, leading to Reihill, J.A.; Crilly, A.; Lockhart, J.C.; Litherland, G.J.; Lundy, F.T.; persistent inflammation, infection and dysregulated protease activity. -
Synthetic Solutions to the Climate Crisis
Synthetic Solutions to the Climate Crisis Synthetic Solutions to the Climate Crisis: The Dangers of Synthetic Biology for Biofuels Production September 2010 www.foe.org 1 Synthetic Solutions to the Climate Crisis Executive Summary iotechnology is portrayed as a panacea for climate change and other societal ills. However the claims that genetically engineered plants and microbes can sequester more carbon in Bthe soil and produce more fuels when processed than conventional methods have yet to be proven. In the wake of these unfulfilled promises emerges a more extreme form of genetic engineering, also touted as the solution to the climate crisis – synthetic biology. Genetic engineering involves inserting genes from one species into another but the goal of synthetic biology is to create life forms from scratch using synthetic, computer-generated DNA or in some cases without the use of DNA entirely. Synthetic biology is not a sustainable solution to the climate crisis and has the potential to create an entirely new set of problems. Genetic contamination – where the genetic makeup of a man-made organism effectively roots out or destroys an indigenous species in the natural environment – is a serious threat to biodiversity, the en- vironment, and public health. This happened when genetically engi- neered crops like corn were introduced in the U.S. in the early 1990s and contaminated entire strains. Synthetic biology exacerbates this problem since no one knows how organisms with synthetic DNA will act in the open environment. They could die immediately – or they could find a niche and devastate ecosystems as other invasive species have done. -
2012 Kaiser Permanente-Authored Publications Alphabetical by Author
2012 Kaiser Permanente-Authored Publications Alphabetical by Author 1. Aaronson DS, Odisho AY, Hills N, Cress R, Carroll PR, Dudley RA, Cooperberg MR Proton beam therapy and treatment for localized prostate cancer: if you build it, they will come Arch Intern Med. 2012 Feb 13;172(3):280-3. Northern California 22332166 KP author(s): Aaronson, David S 2. Abbas MA, Cannom RR, Chiu VY, Burchette RJ, Radner GW, Haigh PI, Etzioni DA Triage of patients with acute diverticulitis: are some inpatients candidates for outpatient treatment? Colorectal Dis. 2012 Oct 12. Southern California 23061533 KP author(s): Abbas, Maher A; Chiu, Vicki Y; Burchette, Raoul J; Radner, Gary W; Haigh, Philip I 3. Abbas MA, Tam MS, Chun LJ Radiofrequency Treatment for Fecal Incontinence: Is It Effective Long-term? Dis Colon Rectum. 2012 May;55(5):605-10. Southern California 22513440 KP author(s): Abbas, Maher A; Tam, Michael S; Chun, Linda J 4. Abdulla FR, Sarpa H, Cassarino D The expression of ALK in mycosis fungoides, stage IA J Cutan Pathol. 2012 Dec 4. Southern California 23205942 KP author(s): Abdulla, Farah R; Sarpa, Hege G; Cassarino, David S 5. Abraham AG, Strickler HD, Jing Y, Gange SJ, Sterling TR, Silverberg M, Saag M, Rourke S, Rachlis A, Napravnik S, Moore RD, Klein M, Kitahata M, Kirk G, Hogg R, Hessol NA, Goedert JJ, Gill MJ, Gebo K, Eron JJ, Engels EA, Dubrow R, Crane HM, Brooks JT, Bosch R, D'Souza G, for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA Invasive cervical cancer risk among HIV-infected women: A North American multi-cohort collaboration prospective study J Acquir Immune Defic Syndr. -
Metabolic Engineering and Synthetic Biology
Engineering Conferences International ECI Digital Archives Metabolic Engineering IX Proceedings Spring 6-3-2012 Conference Program Engineering Conferences International Follow this and additional works at: http://dc.engconfintl.org/metabolic_ix Part of the Biomedical Engineering and Bioengineering Commons Recommended Citation Engineering Conferences International, "Conference Program" in "Metabolic Engineering IX", E. Heinzle, Saarland Univ.; P. Soucaille, INSA; G. Whited, Danisco Eds, ECI Symposium Series, (2013). http://dc.engconfintl.org/metabolic_ix/1 This Article is brought to you for free and open access by the Proceedings at ECI Digital Archives. It has been accepted for inclusion in Metabolic Engineering IX by an authorized administrator of ECI Digital Archives. For more information, please contact [email protected]. Program Metabolic Engineering IX: Metabolic Engineering and Synthetic Biology June 3 –7, 2012 Biarritz, France Conference Co-Chairs Philippe Soucaille Université de Toulouse, INSA, UPS, INP, France Elmar Heinzle Saarland University, Germany Gregg Whited Danisco, USA Engineering Conferences International 32 Broadway, Suite 314, New York, NY 10004, USA Phone: 1 - 212 - 514 - 6760, www.engconfintl.org – [email protected] Le Bellevue Congress and Exhibition Centre Place Bellevue 64200 Biarritz, France Engineering Conferences International (ECI) is a not-for-profit global engineering conferences program, originally established in 1962, that provides opportunities for the exploration of problems and issues of concern to engineers and scientists from many disciplines. ECI BOARD MEMBERS Barry C. Buckland, President Peter Gray Michael King Raymond McCabe David Robinson William Sachs Eugene Schaefer P. Somasundaran Deborah Wiley Chair of ECI Conferences Committee: William Sachs ECI Technical Liaison for this conference: Barry Buckland ECI Executive Director: Barbara K. -
Participant List
Participant List 10/20/2020 12:59:08 PM Category First Name Last Name Position Organization Nationality CSO Jamal Aazizi Chargé de la logistique Association Tazghart Morocco Luz Abayan Program Officer Child Rights Coalition Asia Philippines Babak Abbaszadeh President And Chief Toronto Centre For Global Canada Executive Officer Leadership In Financial Supervision Amr Abdallah Director, Gulf Programs Education for Employment - United States EFE Ziad Abdel Samad Executive Director Arab NGO Network for Lebanon Development TAZI Abdelilah Président Associaion Talassemtane pour Morocco l'environnement et le développement ATED Abla Abdellatif Executive Director and The Egyptian Center for Egypt Director of Research Economic Studies Nabil Abdo MENA Senior Policy Oxfam International Lebanon Advisor Baako Abdul-Fatawu Executive Director Centre for Capacity Ghana Improvement for the Wellbeing of the Vulnerable (CIWED) Maryati Abdullah Director/National Publish What You Pay Indonesia Coordinator Indonesia Dr. Abel Executive Director Reach The Youth Uganda Switzerland Mwebembezi (RTY) Suchith Abeyewickre Ethics Education Arigatou International Sri Lanka me Programme Coordinator Diam Abou Diab Fellow Arab NGO Network for Lebanon Development Hayk Abrahamyan Community Organizer for International Accountability Armenia South Caucasus and Project Central Asia Aliyu Abubakar Secretary General Kano State Peace and Conflict Nigeria Resolution Association Sunil Acharya Regional Advisor, Climate Practical Action Nepal and Resilience Salim Adam Public Health -
Page 1 Jay D Keasling Positions Hubbard Howe, Jr
Jay D Keasling Positions Hubbard Howe, Jr. Distinguished Professor of Biochemical Engineering , Department of Chemical and Biomolecular Engineering, Department of Bioengineering, University of California, Berkeley Associate Laboratory Director and Senior Faculty Scientist , Lawrence Berkeley National Laboratory Chief Executive Officer and Vice President for Fuels Synthesis , Joint BioEnergy Institute Director, Synthetic Biology Engineering Research Center Office Joint BioEnergy Institute 5885 Hollis Street, Fourth Floor Emeryville, CA 94608 Phone: (510) 495-2620 FAX: (510) 495-2630 E-mail : [email protected] , [email protected] Education Postdoctorate , Biochemistry, 1991 -1992, Stanford University Ph.D. , Chemical Engineering, 1991, University of Michigan M.S. , Chemical Engineering, 1988, University of Michigan B.S. , Chemistry and Biology, 1986, University of Nebraska, Lincoln Professional Chief Executive Officer (2007 – present), Joint BioEnergy Institute, Emeryville, CA. Experience Associate Laboratory Director (2010 – present), Acting Deputy Laboratory Director (2009 – 2010), Lawrence Berkeley National Laboratory, Berkeley, CA. Director (2005 – 2009), Senior Faculty Scientist (2006 – present), Faculty Scientist (1992 – 2006), Department Head (2003 – 2005), Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA. Professor (2001 – present), Vice Chair (1999 – 2000), Associate Professor (1998 – 2001), Assistant Professor (1992 – 1998), Department of Chemical Engineering, University of California, Berkeley, -
DNMGA Spring 2021 Newsletter
Durham & Newcastle Medical Graduates Association Newsletter.. Issue 54 Spring 2021 What did you do during lockdown Grandad? We all complain about not having enough time to do the things that we would really like to do. This excuse for being intellectually or physically lazy has been taken away from us by the covid lockdown. What did I do in this enforced rest asks Robert Wilkinson.. The spring lockdown was blessed with good had been a member of the BMA for 50 years the weather making outside chores a pleasure. We BMJ was now free. I didn’t cancel my copy of have a small wood and two paddocks as part of The Quarterly Journal of Medicine which used to our house land and cutting grass, be filled with high science and case reports clearing rhododendrons and chopping of conditions which were so rare that most logs kept me busy. of us were very unlikely to ever see them. It has now come down to earth with Relaxation of the covid rules then less erudite articles often from allowed golf with strict separation of China and other foreign parts and groups so I learned how to book case reports of conditions that the tee time on line. The jobs in the we have usually seen before and wood then suffered but did fill the gaps provide a nice reminder of what we used between golf. The other activity not to know. The New England Journal of requiring much effort or moral fibre was to Medicine is acknowledged to be the best journal read the newspaper each morning before covering general medicine in the world. -
And Rosmarinic Acid- Mediated Life Extension in C. Elegans
Defining Quercetin-, Caffeic acid- and Rosmarinic acid- mediated life extension in C. elegans: Bioassays and expression analyses D i s s e r t a t i o n Zur Erlangung des akademischen Grades d o c t o r r e r u m n a t u r a l i u m (Dr. rer. nat.) im Fach Biologie eingereicht an der Mathematisch-Naturwissenschaftlichen Fakultät I der Humboldt-Universität zu Berlin von Dipl. Biologin Kerstin Pietsch Präsident der Humboldt-Universität zu Berlin Prof. Dr. Jan-Hendrik Olbertz Dekan der Mathematisch-Naturwissenschaftlichen Fakultät I Prof. Dr. Andreas Herrmann Gutachter 1. Prof. Dr. rer. nat. Christian Steinberg 2. Dr. rer. nat. Stephen Stürzenbaum 3. Prof. Dr. rer. nat. Rudolph Achazi Tag der mündlichen Prüfung: 01.12.2011 „Damit das Mögliche entsteht, muss das Unmögliche immer wieder versucht werden.“ Hermann Hesse für meinen Sohn Dean Contents Contents Summary 5 Zusammenfassung 6 List of used Abbrevations 7 1 Introduction 11 1.1 Background 11 1.2 Phytochemicals in plant-based food 11 1.2.1 Polyphenols 12 1.3 The model organism Caenorhabditis elegans 15 1.3.1 C. elegans in aging research 17 1.4 Aging 19 1.4.1 Why do we age? - Selected aging theories 20 1.4.2 Modulation of lifespan: caloric restriction and hormesis 26 1.5 Goals of this study 30 2 Material and methods 34 2.1 Strains and culture conditions 34 2.2 Life table parameters and functional investigations 34 2.2.1 Lifespan assays 34 2.2.2 Reproduction 35 2.2.3 Growth alterations 35 2.2.4 Pharyngeal pumping rate 36 2.2.5 Stress resistance 36 2.2.6 Attraction assay 36 2.2.7 Bacterial growth assay 36 2.2.8 Fluorescence measurements 36 2.2.9 Total Antioxidative Capacity (TAC) 37 2.2.10 Data interpretation and statistical analysis 38 2.3 Molecularbiological experiments 38 2.3.1 Expression levels of heat shock protein genes (hsps) quanified by 38 reverse transcriptase-PCR (qRT-PCR) 2.3.2 DNA-microarray analyses 39 3 Results 41 3.1 Possible artifacts: antimicrobial properties and transgenerational effects 41 3.1.1 Q and RA diminish the bacterial growth of E. -
MEET the FACULTY CANDIDATES Candidates Will Be Present to Meet with Faculty Recruiters on Wednesday, October 16, 2019 from 3:30P
MEET THE FACULTY CANDIDATES Candidates will be present to meet with faculty recruiters on Wednesday, October 16, 2019 from 3:30pm – 5:30pm in Exhibit Hall DE. Admission to the Poster Forum (other than candidates below) are by a business card showing that the individual is a faculty recruiter and a valid BMES Annual Meeting badge. AMR ASHRAF ABDEEN, PhD Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI . [email protected] Research Overview: My interests lie at a unique intersection of biomaterials and mechanobiology, genomics and stem cell therapies. I aim to advance the analysis of biomaterial-cell interaction, fundamental mechanobiology and biomaterials-based therapeutics using novel genome engineering methods in the biomaterials field. My doctoral work focused on the use of biomaterials to probe cell-matrix interaction – how cell matrix affects their differentiation and secretory profile for therapeutic purposes. My postdoctoral work focuses on the more translational usage of biomaterials for therapies. Here, I’ve worked on protein delivery for genome editing, had exposure to state -of the-art regenerative stem cell therapies (for in vivo implantation) and immunotherapies (such as CAR-T therapies). In addition, I now have extensive experience in CRISPR-based genome manipulation for fundamental studies as well as therapeutic purposes. This work involved learning more sophisticated, high-throughput molecular biology assays. One focus of my lab will be studying the more fundamental biomaterials-cell interactions using unbiased biological methods such as high throughput sequencing or functional screens, coupled with a library of biomaterials that covers a wide range of materials properties. Another focus will be the m ore translational aspect of therapeutics, with a focus on delivery techniques for both gene and cell therapies. -
The Chemical and Computational Biology of Inflammation
The chemical and computational biology of inflammation A thesis submitted to the University of Manchester for the degree of Ph.D. in the Faculty of Engineering and Physical Sciences 2011 Ben Small Doctoral Training Centre Integrative Systems Biology Molecules to Life within the School of Chemical Engineering and Analytical Science Table of Contents Title Page………………………………………………………………………………1 Table of Contents ........................................................................................................... 2 List of Figures ................................................................................................................ 3 Abbreviations and Symbols ........................................................................................... 4 Abstract .......................................................................................................................... 9 Lay Abstract – ‘Sifting drug combinations to treat disease’ ........................................ 10 Declaration ................................................................................................................... 11 Copyright Statement .................................................................................................... 11 Acknowledgements ...................................................................................................... 12 Preface and Quotes ....................................................................................................... 14 Chapter 1 Introduction………………………………………………………………….