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Want? Who Are the Doctor Bloggers and What Do They
Downloaded from bmj.com on 3 October 2007 Who are the doctor bloggers and what do they want? Rebecca Coombes BMJ 2007;335;644-645 doi:10.1136/bmj.39349.478148.59 Updated information and services can be found at: http://bmj.com/cgi/content/full/335/7621/644 These include: Rapid responses You can respond to this article at: http://bmj.com/cgi/eletter-submit/335/7621/644 Email alerting Receive free email alerts when new articles cite this article - sign up in the service box at the top left of the article Notes To order reprints follow the "Request Permissions" link in the navigation box To subscribe to BMJ go to: http://resources.bmj.com/bmj/subscribers OBSERVATIONS Downloaded from bmj.com on 3 October 2007 MEDICINE AND THE MEDIA Who are the doctor bloggers and what do they want? Medical blogs are sometimes seen as just rants about the state of health care, but they have also been credited with spreading public understanding of science and rooting out modern day quacks. Rebecca Coombes checks out the medical blogosphere In “internet time” blogging has been around ter at investigative jour- for almost an eternity. Now, with the possible nalism than journalists exception of the odd intransigent high court are. All sorts of facts judge, blogging has achieved household name about dodgy practices status since catching the public’s imagination appear on blogs long nearly a decade ago. before they reach the The medical “blogosphere” is an especially regular magazines or crowded firmament. The opportunity to access papers; that is both fun and useful, I think.” Silver surfer: blogger Professor David Colquhoun raw, unfiltered material, to post instant com- Today annual awards are given for the best ments, and to share information with a (often medical blogs—including a prize for the best ern day quacks, correct ignorant journalism, niche) community has become an addictive literary medical blog—and competing websites digest interesting stories, or comment on big pastime for many doctors. -
Dramatic Synergy in Copt Nanocatalysts Stabilized by ``Click
Dramatic Synergy in CoPt Nanocatalysts Stabilized by “Click” Dendrimers for Evolution of Hydrogen from Hydrolysis of Ammonia Borane Qi Wang, Fangyu Fu, Sha Yang, Marta Martinez Moro, Maria de los Angeles Ramirez, Sergio Moya, Lionel Salmon, Jaime Ruiz, Didier Astruc To cite this version: Qi Wang, Fangyu Fu, Sha Yang, Marta Martinez Moro, Maria de los Angeles Ramirez, et al.. Dramatic Synergy in CoPt Nanocatalysts Stabilized by “Click” Dendrimers for Evolution of Hydrogen from Hydrolysis of Ammonia Borane. ACS Catalysis, American Chemical Society, 2019, 9 (2), pp.1110- 1119. 10.1021/acscatal.8b04498. hal-02335325 HAL Id: hal-02335325 https://hal.archives-ouvertes.fr/hal-02335325 Submitted on 23 Nov 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. ACS Catalysis This document is confidential and is proprietary to the American Chemical Society and its authors. Do not copy or disclose without written permission. If you have received this item in error, notify the sender and delete all copies. Dramatic Synergy in CoPt Nanocatalysts Stabilized by “Click” -
Professor Sir Bernard Katz Biophysicist Who Arrived in England with £4 and Went on to Win a Nobel Prize
THE INDEPENDENT OBITUARIES Saturday 26 April 2003 * 19 Professor Sir Bernard Katz Biophysicist who arrived in England with £4 and went on to win a Nobel Prize BERNARD KATZ was an icon of graduate work, and for this work he war. A month after the wedding he small packets (quanta), each of Although his seriousness could post-war biophysics. He was one of was awarded the Siegfried Garten got a telegram from A.V. Hill which produces a very brief signal in make him appear forbidding, and the last of the generation of prize. This was in 1933, the year inviting him to return to UCL as the muscle fibre. presenting to him the first draft of a distinguished physiologists who were Hitler came to power, and Henry Head Fellow of the Royal His last major works, published in paper could be a "baptism of fire", it refugees from the Third Reich and Gildermeister was forced to Society and assistant director of the 1970s, gave the first insight into was the universal experience of his who contributed immeasurably to the announce publicly that the prize research in biophysics. In 1952 he how a single ion channel behaved, colleagues that he was a person with scientific reputation of their adopted could not be given to a "non-Aryan" succeeded Hill as Professor of and paved the way for Bert enormous enthusiasm, always willing country. In 1970 he won the Nobel student, though he later gave Katz Biophysics at UCL, and he headed a Sakmann, who was at UCL with to discuss with the most junior of Prize in Physiology and Medicine. -
The Reproducibility of Research and the Misinterpretation of P-Values”
1 A response to critiques of “The reproducibility of research and the misinterpretation of p-values” David Colquhoun University College London, Gower Street, London WC1E 6BT. Address for correspondence: [email protected] This version will appear in Royal Society Open Science. Cite as: Colquhoun D. 2019 A response to critiques of ‘The reproducibility of research and the misinterpretation of p-values’. R. Soc. open sci. 6: 190819. http://dx.doi.org/10.1098/rsos.190819 2 1. Introduction I proposed (8, 1, 3) that p values should be supplemented by an estimate of the false positive risk (FPR). FPR was defined as the probability that, if you claim that there is a real effect on the basis of p value from a single unbiased experiment, that you will be mistaken and the result has occurred by chance. This is a Bayesian quantity and that means that there is an infinitude of ways to calculate it. My choice of a way to estimate FPR was, therefore, arbitrary. I maintain that it’s a reasonable way, and has the advantage of being mathematically simpler than other proposals and easier to understand than other methods. This might make it more easily accepted by users. As always, not every statistician agrees. This paper is a response to a critique of my 2017 paper (1) by Arandjelovic (2). 2. First some minor matters In his critique of my 2017 paper (1), Arandjelovic says (2) that my argument “provides little if any justification for the continued use of the p-value”. I agree because I never contended that it did. -
David Colquhoun Conducted by Jonathan Ashmore on 3 and 17 June 2014 Published February 2015
An interview with David Colquhoun Conducted by Jonathan Ashmore on 3 and 17 June 2014 Published February 2015 This is the transcript of an interview of the Oral Histories Project for The Society's History & Archives Committee. The original digital sound recording is lodged with The Society and will be placed in its archive at The Wellcome Library. An interview with David Colquhoun David Colquhoun photographed by Jonathan Ashmore, June 2014. This interview with David Colquhoun (DC) was conducted by Jonathan Ashmore (JA) at University College London on 3 and 17 June 2014. (The transcript has been edited by David Miller.) Student life JA: I’m sitting surrounded by multiple files from David, computer screens and all sorts of interesting papers. David, I think the most useful thing is if we proceeded chronologically, so what I’d like to know first of all is how you got interested in science in the first place. DC: I wasn’t very interested in science at school; it was … a direct grant school but it tried to ape more expensive schools. The only thing that really mattered was sport there [laughs], and I did a bit of that but I just simply didn’t take any interest at all in any academic subject. The pinnacle of my academic achievement was to fail O-Level geography three consecutive times, getting lower marks at each attempt. I was quite proud of that. No one had ever done it. So I left after the third attempt and went to Liverpool Technical College, as it was then called, probably university by now, and did my A-Levels there. -
The Session Program
1 Session Name Fundamental and Applied Aspects of N2 Coordination Chemistry Professor Yoshiaki Nishibayashi Japan University of Tokyo Professor Hiroyuki Kawaguchi Japan Tokyo Institute of Technology Professor Michael Fryzuk Canada University of British Columbia Professor Jonas Peters USA California Institute of Technology Professor Sven Schneider Germany Gottingen University 2 Session Name Small Molecule Activation Assistant Professor Alexander Parent USA North Dakota State University Associate Professor Shigeyuki Masaoka Japan Institute for Molecular Science Associate Professor Tohru Wada Japan Rikkyo University Associate Professor Curtis Berlinguette Canada The University of British Columbia Professor Marc Robert France University of Paris Diderot 3 Session Name Coordination Chemistry for Energy and Environment Chief Senior researcher and Professor Qiang Xu Japan National Institute of Advanced Industrial Science and Technology (AIST) and Kobe University Professor Osamu Ishitani Japan Tokyo Institute of Technology Professor Jing Li USA Rutgers University Research Director Christian Serre France CNRS and Ecole Normale Superieure Professor Wai-yeung Wong China The Hong Kong Polytechnic University 4 Session Name Phosphorus(III) Based Ligands: Coordination Chemistry and Catalysis Professor Maravanji S. Balakrishna India Department of Chemistry Indian Institute of Technology Bombay Institute for Chemical Research, Kyoto University Professor Fumiyuki Ozawa Japan International Research Center for Elements Science Institute for Chemical Research, -
University of Dundee Science Blogging Riesch, Hauke
University of Dundee Science blogging Riesch, Hauke; Mendel, Jonathan Published in: Science As Culture DOI: 10.1080/09505431.2013.801420 Publication date: 2014 Document Version Peer reviewed version Link to publication in Discovery Research Portal Citation for published version (APA): Riesch, H., & Mendel, J. (2014). Science blogging: networks, boundaries and limitations. Science As Culture, 23(1), 51-72. 10.1080/09505431.2013.801420 General rights Copyright and moral rights for the publications made accessible in Discovery Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from Discovery Research Portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain. • You may freely distribute the URL identifying the publication in the public portal. Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 17. Mar. 2016 Science Blogging: Networks, Boundaries and Limitations HAUKE RIESCH* & JONATHAN MENDEL** *Department of Sociology and Communications, School of Social Sciences, Brunel University, London, UK **Geography, School of the Environment, University of Dundee, Dundee, UK ABSTRACT There is limited research into the realities of science blogging, how science bloggers themselves view their activity and what bloggers can achieve. The ‘badscience’ blogs analysed here show a number of interesting developments, with significant implications for understandings of science blogging and scientific cultures more broadly. -
Supported Dendrimer-Encapsulated Metal Clusters: Toward Heterogenizing Homogeneous Catalysts † ‡ § † † § † § Rong Ye, , , Aleksandr V
This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Article pubs.acs.org/accounts Supported Dendrimer-Encapsulated Metal Clusters: Toward Heterogenizing Homogeneous Catalysts † ‡ § † † § † § Rong Ye, , , Aleksandr V. Zhukhovitskiy, Christophe V. Deraedt, , F. Dean Toste,*, , † ‡ § and Gabor A. Somorjai*, , , † ‡ Department of Chemistry, Kavli Energy NanoScience Institute, University of California, Berkeley, Berkeley, California 94720, United States § Chemical Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States CONSPECTUS: Recyclable catalysts, especially those that display selective reactivity, are vital for the development of sustainable chemical processes. Among available catalyst platforms, heterogeneous catalysts are particularly well-disposed toward separation from the reaction mixture via filtration methods, which renders them readily recyclable. Furthermore, heterogeneous catalysts offer numer- ous handlessome without homogeneous analoguesfor performance and selectivity optimization. These handles include nano- particle size, pore profile of porous supports, surface ligands and interface with oxide supports, and flow rate through a solid catalyst bed. Despite these available handles, however, conventional heterogeneous catalysts are themselves often structurally heterogeneous compared to homogeneous catalysts, which complicates efforts to optimize and expand the scope of their reactivity and selectivity. Ongoing efforts in our laboratories are aimed to address the above challenge by heterogenizing homogeneous catalysts, which can be defined as the modification of homogeneous catalysts to render them in a separable (solid) phase from the starting materials and products. Specifically, we grow the small nanoclusters in dendrimers, a class of uniform polymers with the connectivity of fractal trees and generally radial symmetry. -
Single-Channel Recordings of Three K+-Selective Currents in Cultured Chick Ciliary Ganglion Neurons
The Journal of Neurosctence July 1986, 6(7): 2106-2116 Single-Channel Recordings of Three K+-Selective Currents in Cultured Chick Ciliary Ganglion Neurons Phyllis I. Gardner Department of Pharmacology, University College London, and Department of Medicine, Stanford University Medical Center, Stanford, California 94305 Multiple distinct K+-selective channels may contribute to action for a multiplicity of outward K+ currents includesidentification potential repolarization and afterpotential generation in chick of complex gating kinetics and separationof individual current ciliary neurons. The channel types are difficult to distinguish components by pharmacological manipulations. Characteriza- by traditional voltage-clamp methods, primarily because of tion of the individual componentsof outward K+ current is of coactivation during depolarization. I have used the extracellular fundamental interest, since K+ conductancesappear to be in- patch-clamp technique to resolve single-channel K+ currents in volved in such physiological processesas resting potential de- cultured chick ciliary ganglion (CC) neurons. Three unit cur- termination, action potential repolarization, afterpotential gen- rents selective for K+ ions were observed. The channels varied eration, and control of repetitive firing. Moreover, K+ channels with respect to unit conductance, sensitivity to CaZ+ ions and may be an important site for neurotransmitter modulation of voltage, and steady-state gating parameters. The first channel, neuronal excitability (for review, seeHartzell, 1981). However, GK,, was characterized by a unit conductance of 14 pica-Sie- the identification and characterization of the individual com- mens (pS) under physiological recording conditions, gating that ponents of outward K+ current by voltage-clamp analysis has was relatively independent of membrane potential and intracel- been difficult, primarily becauseall components can be coac- lular Ca*+ ions, and single-component open-time distributions tivated during depolarization. -
Organometallic Chemistry at the Nanoscale
Pure Appl. Chem., Vol. 75, No. 4, pp. 461–481, 2003. © 2003 IUPAC Organometallic chemistry at the nanoscale. Dendrimers for redox processes and catalysis* Didier Astruc Laboratoire de Chimie Organique et Organométallique, UMR CNRS No 5802, Université Bordeaux I, 33405 Talence Cedex, France Abstract: An overview of the metal-mediated synthesis and use of nanosized metalloden- drimers is given with emphasis on electron-transfer processes (molecular batteries consisting in dendrimers decorated with a large number of equivalent redox-active centers) and catalytic reactions (electron-transfer-chain catalytic synthesis of dendrimers decorated with ruthenium carbonyl clusters, redox catalysis of nitrate and nitrite electroreduction in water by star-shape hexanuclear catalysts). INTRODUCTION Although most rules of stoichiometric and catalytic organometallic activation are now known [1], there remains a wide-open field of research for development and applications using the exploration of the best metal-ligand combination toward a given reaction. Present examples can now be found in metathesis that remained restricted to nonfunctional olefins for a long time until the recent successful efforts of Grubbs’ [2] and Schrock’s groups [3]. Their commercial catalysts are now of everyday use for organic and polymer chemists. A previous success story of this kind started in 1970 when Kagan first published efficient asymmetric catalysis with the powerful concept of chiral chelating phosphine [4]. This idea led many chemists, including other prestigious ones, to find optically active drugs with close to 100 % ee, an essential requirement for safe use by the public [5]. What now remains to be done? Indeed, the task is enormous for 21st century organometallic and molecular chemists. -
Metathesis Reactions: Recent Trends and Challenges
MICROREVIEW DOI:10.1002/ejic.201300682 Metathesis Reactions: Recent Trends and Challenges Christophe Deraedt,[a] Martin d’Halluin,[a] and Didier Astruc*[a] Keywords: Metathesis / Supported catalysts / Z-selectivity / Alkynes Metathesis reactions are now essential for the synthesis of removing metal impurities from products towards “green complex organic molecules; a large variety of useful materi- chemistry” are briefly reviewed. The relationship of olefin als are available, and progress in this field is growing rapidly. metathesis is shown with the alkyne metathesis reaction that Emphasis in this review on metathesis is placed on the recent was exploited by Fürstner, with alkane metathesis that was developments of stereoselectivity aspects by using new fami- achieved by using surface organometallic chemistry and lies of molybdenum (Schrock type) and ruthenium (Grubbs highlighted by Basset, and with the use of classic organome- type) catalysts for olefin metathesis. Recent progress in al- tallic catalysts by the Goldman and Brookhart groups. Fi- kyne metathesis catalysts (Fürstner type) and their properties nally, recent developments in polymer chemistry that involve and impressive synthetic applications are highlighted as well stereochemical control, low polydispersities, and applications as new terminal alkyne metathesis catalysts (Tamm type). are summarized. The various strategies involved in recovering the catalyst and Contents 3. Enantioselectivity and Stereoselectivity in Alkene Metathesis 1. Introduction 4. Catalyst Recovery and Methods To Avoid Metal 2. Classic Alkene Metathesis Catalysts and Reaction Types Contamination 5. Alkyne Metathesis [a] ISM, UMR CNRS 5255, Univ. Bordeaux, 6. Alkane Metathesis 33405 Talence Cedex, France E-mail: [email protected] 7. Polymer Chemistry Homepage: astruc.didier.free.fr 8. -
Annual Activities Report and Accounts for the Period 1
ANNUAL ACTIVITIES REPORT AND ACCOUNTS FOR THE PERIOD 1 April - 31 December 2012 ‘The Academy of Europe’ Registered office 21, Albemarle Street, London. W1S 4HS, United Kingdom Tele: +44 (0) 20 7495 3717 Fax: +44 (0) 20 7629 5442 Email: [email protected] Web: http://www.acadeuro.org Company limited by Guarantee and registered at Companies House. Registration number 7028223 Registered with the Charity Commission, registration number 1133902 1 THE TRUSTEES, AND COUNCIL OF THE ACADEMIA EUROPAEA Board of TRUSTEES (at 31 December 2012) President: Professor Lars Walløe Oslo (till 2014) Vice President: Professor Sierd Cloetingh Amsterdam (till 2014) Vice President: Professor Anne Buttimer Dublin (till 2015) Hon. Treasurer: (from January 2010) Professor Sir Roger Elliott Oxford (till 2015) Foreign Secretary Professor Jerzy Langer Warsaw (co-opted) Members Professor Michel Che Paris (till 2013) Professor Peter Emmer Leiden (till 2013) Professor Cinzia Ferrini Trieste (till 2013) Professor Andreu Mas Colell Barcelona (co-opted) till 2015 Professor Theo D’haen Leuven (co-opted) till 2015 Professor Ole Petersen Cardiff (co-opted) till 2015 Professor Hermann Maurer Graz (co-opted Jan 1 2013) Advisory Council Members (independent elected members only): Professor Susan Bassnett Warwick (till 2013) Professor Cinzia Ferrini Trieste (till 2013) Professor Balazs Gyulas Stockholm (till 2013 – eligible for re-appointment) At the time of writing this report, the number of independent, elected members to Council was set at a maximum of 3. The Chairs of the Academic Sections are all de facto members of the Advisory Council. Periods of office of Section chairs are set out in the regulations. The list of Section chairs, as at 31 December 2012, is at annex 1a of this report.