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Department of Biology DEPARTMENT OF BIOLOGY DEPARTMENT OF BIOLOGY 7.014 Introductory Biology U (Spring) 5-0-7 units. BIOLOGY Undergraduate Subjects Credit cannot also be received for 7.012, 7.015, 7.016, ES.7012, ES.7013 Introductory Biology All ve subjects cover the same core material, comprising about 50% Studies the fundamental principles of biology and their application of the course, while the remaining material is specialized for each towards understanding the Earth as a dynamical system shaped by version as described below. Core material includes fundamental life. Focuses on molecular ecology in order to show how processes at principles of biochemistry, genetics, molecular biology, and cell the molecular level can illuminate macroscopic properties, including biology. These topics address structure and regulation of genes, evolution and maintenance of biogeochemical cycles, and ecological structure and synthesis of proteins, how these molecules are interactions in ecosystems ranging from the ocean to the human integrated into cells and how cells communicate with one another. gut. Includes quantitative analysis of population growth, community structure, competition, mutualism and predation; highlights their 7.012 Introductory Biology role in shaping the biosphere. Enrollment limited to seating capacity Prereq: None of classroom. Admittance may be controlled by lottery. U (Fall) G. C. Walker, D. Des Marais 5-0-7 units. BIOLOGY Credit cannot also be received for 7.014, 7.015, 7.016, ES.7012, 7.015 Introductory Biology ES.7013 Prereq: High school course covering cellular and molecular biology or permission of instructor Exploration into areas of current research in molecular and cell U (Fall) biology, immunology, neurobiology, human genetics, biochemistry, 5-0-7 units. BIOLOGY and evolution. Enrollment limited to seating capacity of classroom. Credit cannot also be received for 7.012, 7.014, 7.016, ES.7012, Admittance may be controlled by lottery. ES.7013 C. Drennan, L. Guarente Emphasizes the application of fundamental biological principles 7.013 Introductory Biology to modern, trending topics in biology. Specic modules focus Prereq: None on antibiotic resistance, the microbiome, biotechnology (e.g., Acad Year 2021-2022: U (Spring) genetically-modied organisms and CRISPR-based genome editing), Acad Year 2022-2023: Not oered personal genetics and genomics, neurodegenerative diseases, and 5-0-7 units. BIOLOGY metabolism (the science behind making wine, cheese, and natural product drugs). Includes discussion of the social and ethical issues Genomic approaches to human biology, including neuroscience, surrounding modern biology. Limited to 60; admittance may be development, immunology, tissue repair and stem cells, tissue controlled by lottery. engineering, and infectious and inherited diseases, including S. Vos, J. K. Weng cancer. Enrollment limited to seating capacity of classroom. Admittance may be controlled by lottery. A. Amon, S. Bell, H. Sive Department of Biology | 3 DEPARTMENT OF BIOLOGY 7.016 Introductory Biology 7.003[J] Applied Molecular Biology Laboratory Prereq: None Same subject as 10.7003[J] U (Spring) Prereq: 7.002 5-0-7 units. BIOLOGY U (Fall, Spring) Credit cannot also be received for 7.012, 7.014, 7.015, ES.7012, 2-7-3 units. Partial Lab ES.7013 Laboratory-based exploration of modern experimental molecular Introduction to fundamental principles of biochemistry, molecular biology. Specic experimental system studied may vary from term to biology and genetics for understanding the functions of living term, depending on instructor. Emphasizes concepts of experimental systems. Covers examples of the use of chemical biology, the use of design, data analysis and communication in biology and how these genetics in biological discovery, principles of cellular organization concepts are applied in the biotechnology industry. Satises 6 and communication, immunology, cancer, and engineering biological units of Institute Laboratory credit. Limited to 50 due to laboratory systems. In addition, includes 21st-century molecular genetics capacity. in understanding human health and therapeutic intervention. Fall: E. Calo; Spring: L. Case, J. K. Weng Enrollment limited to seating capacity of classroom. Admittance may be controlled by lottery. 7.03 Genetics B. Imperiali, A. Martin Prereq: Biology (GIR) U (Fall, Spring) 7.00 COVID-19, SARS-CoV-2 and the Pandemic 4-0-8 units. REST Prereq: None U (Fall) The principles of genetics with application to the study of biological 1-0-1 units function at the level of molecules, cells, and multicellular organisms, including humans. Structure and function of genes, chromosomes, Lectures by leading experts on the fundamentals of COVID-19 and genomes. Biological variation resulting from recombination, epidemiology, coronavirus and host cell biology, immunity, vaccine mutation, and selection. Population genetics. Use of genetic development, clinical disease and therapy. Subject can count toward methods to analyze protein function, gene regulation, and inherited the 6-unit discovery-focused credit limit for rst year students. disease. R. Young, F. Batista Fall: M. Gehring, P. Reddien; Spring: M. Hemann, J. Weissman 7.002 Fundamentals of Experimental Molecular Biology 7.05 General Biochemistry Prereq: None Prereq: Biology (GIR), 5.12, or permission of instructor U (Fall, Spring) U (Spring) 1-4-1 units. Partial Lab 5-0-7 units. REST Credit cannot also be received for 5.07[J], 20.507[J] Introduces the experimental concepts and methods of molecular biology. Covers basic principles of experimental design and Contributions of biochemistry toward an understanding of the data analysis, with an emphasis on the acquisition of practical structure and functioning of organisms, tissues, and cells. Chemistry laboratory experience. Satises 6 units of Institute Laboratory credit. and functions of constituents of cells and tissues and the chemical Enrollment limited. and physical-chemical basis for the structures of nucleic acids, A. Martin proteins, and carbohydrates. Basic enzymology and biochemical reaction mechanisms involved in macromolecular synthesis and degradation, signaling, transport, and movement. General metabolism of carbohydrates, fats, and nitrogen-containing materials such as amino acids, proteins, and related compounds. M. Vander Heiden, M. Yae 4 | Department of Biology DEPARTMENT OF BIOLOGY 7.06 Cell Biology 7.094 Modern Computational Biology Prereq: 7.03 and 7.05 Subject meets with 7.574 U (Fall, Spring) Prereq: 7.03 and 7.05 4-0-8 units U (Spring; second half of term) 2-0-4 units Presents the biology of cells of higher organisms. Studies the structure, function, and biosynthesis of cellular membranes and Introduces modern methods in computational biology, focusing on organelles; cell growth and oncogenic transformation; transport, DNA/RNA/protein sequence analysis. Topics include next-generation receptors, and cell signaling; the cytoskeleton, the extracellular DNA sequencing and sequencing data analysis, RNA-seq (bulk and matrix, and cell movements; cell division and cell cycle; functions of single-cell), ribosome proling, and proteomics. Students registered specialized cell types. Emphasizes the current molecular knowledge for the graduate version complete an additional project, applying of cell biological processes as well as the genetic, biochemical, and bioinformatic methods to data from their research. other experimental approaches that resulted in these discoveries. A. Jain, G. W. Li Fall: P. Li, S. Lourido; Spring: I. Cheeseman, R. Lamason 7.102 Introduction to Molecular Biology Techniques 7.08[J] Fundamentals of Chemical Biology Prereq: None Same subject as 5.08[J] U (IAP) Subject meets with 7.80 0-5-1 units. Partial Lab Prereq: (Biology (GIR), 5.13, and (5.07[J] or 7.05)) or permission of instructor Designed primarily for rst-year students with little or no lab U (Spring) experience. Introduces basic methods of experimental molecular 4-0-8 units biology. Specic experiments vary from year-to-year, but will focus on the identication and characterization of bacteria and See description under subject 5.08[J]. bacteriophages from the wild using an array of basic methods in B. Imperiali, R. Raines molecular biology and microbiology. Biology GIR or Chemistry GIR recommended. Satises 6 units of Institute Laboratory credit. 7.093 Modern Biostatistics Limited to 16; admittance may be controlled by lottery. Subject meets with 7.573 A. Martin Prereq: 7.03 and 7.05 U (Spring; rst half of term) 7.11 Biology Teaching 2-0-4 units Prereq: None U (Fall, Spring) Provides an introduction to probability and statistics used in Units arranged modern biology. Discrete and continuous probability distributions, Can be repeated for credit. statistical modeling, hypothesis testing, Bayesian statistics, independence, conditional probability, Markov chains, methods For qualied undergraduate students interested in gaining some for data visualization, clustering, principal components analysis, experience in teaching. Laboratory, tutorial, or classroom teaching nonparametric methods, Monte Carlo simulations, false discovery under the supervision of a faculty member. Students selected by rate. Applications to DNA, RNA, and protein sequence analysis; interview. genetics; genomics. Homework involves the R programming Consult Sta language, but prior programming experience is not required. Students registered for the graduate version complete an additional 7.19 Communication in Experimental Biology project, applying biostatistical methods
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