DOCSLIB.ORG

Front Matter (PDF)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Front Matter (PDF) When moving ahead means not momng at all. When you're probing or recording at Because accidents hap- the single-cell level, there's no room for pen, our exclusive CleanTop error, or vibration. surface design safely con- That's why leading researchers world- tains spills of water and other wide specify TMC vibration corrosive liquids. And it also isolation systems: laboratory maintains the highest level of structural damping and The 1-inch long welded tables, optical tables, and steel cups in our patented table-top and floor platforms. stiffness needed for the most CleanTop honeycomb top Our patented Gimbal Piston ®Air critical applications, safely contain spills. Isolator System effectively eliminates So when you absolutely need to move ahead, both vertical and horizontal floor vibra- move up to TMC, the world's most intelligent Ouroil-free Gimbal tion. When it's combined with our vibration solution. Contact our Technical Sales Piston provides isolation unique, highly damped, stainless steel in all directions, for even Group today. I the lowest input levels, laminate top or all-steel, spillproof CleanTop,~ iM you are assured of unequalled Technical Manufacturing Corporatlon 15 Centennial Drive • Peabody, MA 01960, USA performance, guaranteed. Our stainless steel laminated top is ideal Tel: 508-532-6330 • 800-542-9725 Fax: 508-531-8682 if mounting holes are not required. Vibmlion Solutions NG Editors Ronald Davis (Houston) Richard Morris (Edinburgh) Larry Squire (San Diego) Eric Kandel (New York) Carla Shatz (Berkeley) Charles Stevens (La Jolla) Managing Editor Judy Cuddihy (Cold Spring Harbor) Editorial Board Per Anderson (Oslo) Martin Heisenberg (Wurzburg) Philippe Ascher (Paris) Susan Hockfleld (New Haven) Man D. Baddeley (Cambridge) Lawrence C. Katz (Durham) Carole A. Barnes (Tucson) Mary B. Kennedy (Pasadena) Timothy Bliss (London) Joseph Le Doux (New York) John Byrne (Houston) Hans-Peter Lipp (Zurich) Thomas J. Carew (New Haven) Stephen G. Lisberger (San Francisco) Graham Collingridge (Birmingham) Nick J. Mackintosh (Cambridge) John Conner (Nutley) Daniel Madison (Stanford) Thomas Curran (Nutley) Randolf Menzel (Berlin) Antonio Damasio (Iowa City) Mortimer Mishkin (Bethesda) Michael Davis (New Haven) Dennis D.M. O'Leary (LaJolla) Pietro De Camili (New Haven) Marcus Raichle (St. Louis) Yadin Dudai (Rehovot) Robert Rescorla (Philadelphia) Howard Eichenbaum (Stony Brook) Daniel Schacter (Cambridge) Yves Fr~gnac (Gif sur Yvette) James Schwartz (New York) Alison Goate (St. Louis) Wolf Singer (Frankfurt) Michael E. Greenberg (Boston) Richard Thompson (Los Angeles) Stephen Heinemann (La Jolla) Richard Tsien (Stanford) Editorial Offices Editorial/Production Cold Spring Harbor Laboratory Press Nadine Dumser, Technical Editor 1 Bungtown Road Valerie Nicolette, Production Editor Cold Spring Harbor, New York 11724 Doris Lawrence, Editorial Secretary Phone (516) 367-8492 Fax (516) 367-8532 Learning & Memory (ISSN 1072-0502) is face mail, $157 with airlift delivery. Orders photocopy items for internal or personal published bimonthly for $127 (U.S. institu- may be sent to Cold Spring Harbor Labora- use of specific clients is granted by Cold tional; $137 rest of world; $157 R.O.W. tory Press, Fulfillment Department, 10 Sky- Spring Harbor Laboratory Press for Librar- with airlift), $57 (individual making per- line Drive, Plainview, New York 11803- ies and other users registered with the sonal payment; $67 R.O.W. surface; $87 2500. Telephone: Continental U.S. and Can- Copyright Clearance Center (CCC) Trans- with airlift) by Cold Spring Harbor Labora- ada 1-800-843-4388; all other locations actional Reporting Service, provided that tory Press, 1 Bungtown Road, Cold Spring 516-349-1930. FAX: 516-349-1946. Per- the base fee of $5.00 per copy is paid di- Harbor, New York 11724. Second class sonal subscriptions must be prepaid by per- rectly to CCC, 21 Congress Street, Salem, postage pending is paid at Cold Spring Har- sonal check, credit card, or money order. Massachusetts 01970 (1072-0502/94 + bor and additional mailing offices. POST- Claims for missing issues must be received $5.00). This consent doe~not extend to MASTER: Send address changes to Cold within 4 months of issue date. other kinds of copying, such as copying for Spring Harbor Laboratory Press, 10 Skyline Advertising: Nancy Kuhle, Advertising general distribution for advertising or pro- Drive, Plainview, New York 11803-2500. Manager, Cold Spring Harbor Laboratory motional purposes, for creating new collec- Subscriptions: Barbara Terry, Subscrip- Press, 1 Bungtown Road, Cold Spring Har- tive works, or for resale. tion Manager. Personal: U.S. $57, 1LO.W. bor, New York 11724-2203. Phone: 516- $67 surface mail, $87 with airlift delivery. 367-8351. FAX: 516-367-8532. Copyright © 1994 by Cold Spring Harbor Institutional: U.S. $127; ILO.W. $137 sur- Copyright information: Authorization to Laboratory Press Introduction The introduction of a new journal LEARNING Fifth, and finally, the study of learning may & MEMORY by the Cold Spring Harbor Laboratory carry with it a special bonus. It may also provide Press reflects the conviction of the Editorial Board insights into one of the key mechanisms of neural that the biological study of learning is entering a development--the fine-tuning of synaptic connec- new and exciting phase. Although the study of tions. We have learned recently that the steps learning has traditionally been central to neu- whereby each axon is matched to specific postsyn- ropsychology, cognitive psychology, and to ethol- aptic target neurons occur through activity-depen- ogy, until quite recently this study was not a major dent mechanisms and that these mechanisms pro- concern for cell and molecular neurobiologists. duce the final point-to-point order required for the Within the last few years the situation has changed mature function of neural systems. Activity-depen- dramatically. The study of learning has suddenly dent selection seems to be required to fine-tune become a central and rapidly expanding field the connections but constitute the representation within biology. of many (perhaps all) sensory systems in the brain. Why has learning suddenly attracted a large Indeed, many of these connections can be modi- number of biologists? There are probably several fied by activity throughout the adult life of the reasons for this change. First, since the classic organism, illustrating a temporal continuity be- studies of the patient H.M., who had a bilateral tween development and learning. The specific removal of the medial temporal lobe, behavioral mechanisms for these activity-dependent changes understanding of the different forms of learning are not known. But the best candidates that have and memory has improved. so far emerged for these developmental processes, Second, neurobiologists have made remark- are those, like long-term potentiation, that utilize a able progress in analyzing, on the molecular level, Hebb-like mechanism similar to that employed for both the voltage-gated ion channels important for certain forms of learning and memory storage in impulse activity in nerve cells and the ligand-gated the adult animal. channels important for synaptic transmission. This For these several reasons we are launching success has not only increased the confidence of this journal, LEARNING & MEMORY, not passively neurobiologists but also has enhanced the concep- but proactively. We plan to do more than respond tual and methodological power that can now be to the perceived need for a journal that would brought to bear on the study of vesicle exocytosis welcome papers on learning, ranging from cogni- and synaptic plasticity. As a result, a number of tive studies in humans to molecular studies in in- molecular neurobiologists now are eager to tackle vertebrates. Rather, we are starting the journal more complex problems involving the modifiabil- with the idea of contributing actively to the intel- ity of systems of neurons. The most interesting of lectual growth of the field. We see this journal as these systems control behavior that can be modi- facilitating a new synthesis between the various fied by learning. areas concerned with the study of learning--be- Third, there is a gradual appreciation that tween cognitive studies of learning and memory, learning is central not only to cognitive psychol- computational and experimental studies of com- ogy but also to neural science. It is hard to think of plex systems, and cell and molecular biological making progress in either field without first under- studies of exocytosis and synaptic plasticity in sim- standing how behavior is generated, how it is mod- ple experimental systems. Indeed, it is our convic- ified by learning, and how that modification is tion that learning and memory represent the most stored by nerve cells as memory. Certainly, the promising domain of behavior for achieving a co- central aspect of any animal's behavior is the abil- herent unification of brain and mind. ity to learn from experience--an ability that We therefore eagerly welcome important pa- reaches its highest form in humans. Moreover, sev- pers in all areas of learning and memory. We seek eral of the most devastating neurological diseases to publish on topics ranging from human amnesia that afflict humankindmDown's syndrome, Hun- to gene expression, from systems neurobiological tington's disease, Alzheimer's diseaseminvolve studies of learning to synaptic plasticity in disas- loss of memory. sociated culture. We also welcome papers address- But interest is not usually sufficient to recruit ing the psychological processes of learning and serious commitments. The fourth reason that has memory, particularly where these are likely to captured the interest of many scientists was the have an impact upon neurological work. Our aim conviction that learning and memory are now ap- is to assure readability, high scientific standards, proachable with a wide variety of techniques rang- and good critical reviews of all areas important to ing from neuroimaging to cognitive psychology, the coherent study of learning and memory. from computational studies to studies of neural systems, from cell biology to genetically modified animals.
Load more

Recommended publications
  • Long-Term Potentiation: What’S Learning Got to Do with It?
    BEHAVIORAL AND BRAIN SCIENCES (1997) 20, 597±655 Printed in the United States of America Long-term potentiation: What's learning got to do with it? Tracey J. Shors Department of Psychology and Program in Neuroscience, Princeton University, Princeton, NJ 08544 Electronic mail: shors࠾princeton.edu Louis D. Matzel Department of Psychology, Program in Biopsychology and Behavioral Neuroscience, Rutgers University, New Brunswick, NJ 08903 Electronic mail: matzel࠾rci.rutgers.edu Abstract: Long-term potentiation (LTP) is operationally defined as a long-lasting increase in synaptic efficacy following high-frequency stimulation of afferent fibers. Since the first full description of the phenomenon in 1973, exploration of the mechanisms underlying LTP induction has been one of the most active areas of research in neuroscience. Of principal interest to those who study LTP, particularly in the mammalian hippocampus, is its presumed role in the establishment of stable memories, a role consistent with ªHebbianº descriptions of memory formation. Other characteristics of LTP, including its rapid induction, persistence, and correlation with natural brain rhythms, provide circumstantial support for this connection to memory storage. Nonetheless, there is little empirical evidence that directly links LTP to the storage of memories. In this target article we review a range of cellular and behavioral characteristics of LTP and evaluate whether they are consistent with the purported role of hippocampal LTP in memory formation. We suggest that much of the present focus on LTP reflects a preconception that LTP is a learning mechanism, although the empirical evidence often suggests that LTP is unsuitable for such a role. As an alternative to serving as a memory storage device, we propose that LTP may serve as a neural equivalent to an arousal or attention device in the brain.
    [Show full text]
  • Press Release
    PRESS RELEASE STRICTLY EMBARGOED UNTIL 14.00 GMT 1 MARCH 2016 Ground-breaking research into memory honoured with the world’s largest prize for brain research Three British neuroscientists have today (1 March) won the world’s most valuable prize for brain research, for their outstanding work on the mechanisms of memory. This year’s winners of The Brain Prize are Tim Bliss, Graham Collingridge and Richard Morris. The Brain Prize, awarded by the Grete Lundbeck European Brain Research Foundation in Denmark is worth one million Euros. Awarded annually, it recognises one or more scientists who have distinguished themselves by an outstanding contribution to neuroscience. The research by Professors Bliss, Collingridge and Morris has focused on a brain mechanism known as ‘Long-Term Potentiation’ (LTP), which underpins the life-long plasticity of the brain. Their discoveries have revolutionised our understanding of how memories are formed, retained and lost. The three neuroscientists have independently and collectively shown how the connections – the synapses - between brain cells in the hippocampus (a structure vital for the formation of new memories) can be strengthened through repeated stimulation. LTP is so-called because it can persist indefinitely. Their work has revealed some of the basic mechanisms behind the phenomenon and has shown that LTP is the basis for our ability to learn and remember. Sir Colin Blakemore, chairman of the selection committee said “Memory is at the heart of humanexperience. This year’s winners, through their ground-breaking research, have transformed our understanding of memory and learning, and the devastating effects of failing memory.” Without the capacity to store information in our brains, we could not remember our past and would be incapable of planning our future.
    [Show full text]
  • The Historical Significance of the Discovery of Long Term Potentiation: an Overview and Evaluation for Non-Experts
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Portsmouth University Research Portal (Pure) Running head: LONG TERM POTENTIATION 1 The Historical Significance of the Discovery of Long Term Potentiation: An Overview and Evaluation for Non-Experts Lawrence Patihis, University of Southern Mississippi accepted article in the journal American Journal of Psychology Address correspondence to: Lawrence Patihis, Department of Psychology, University of Southern Mississippi, 118 College Drive #5025, Hattiesburg, MS, 39406, USA. E-mail: [email protected] Abstract This article evaluates in non-technical language for those not familiar with neuroscience jargon the historical significance of Bliss and Lømo’s (1973) landmark discovery of long term potentiation (LTP) by establishing precedent context, describing the finding, and then looking at the subsequent decades of LTP research. To set the LTP discovery in context, the article briefly reviews the precedent theories of synaptic information storage, and the empirical precedents of frequency potentiation, synaptic facilitation, and the identification of the hippocampal area as being memory-related. I then discuss and explain Bliss and Lømo’s initial work whereby they found synaptic strengthening that lasted for hours. To better evaluate the importance of their discovery, the article discusses the confirmatory evidence of the decades of LTP research that followed. In this way the article evaluates the replicability, generalizability, and mechanisms behind the phenomena. Perhaps most importantly, I discuss the evidence for LTP being an important mechanism that explains some aspects of learning and memory. The article concludes that at this time Bliss and Lømo’s discovery looks to be a profound discovery in the history of science.
    [Show full text]
  • Cognitive Neuroscience Review and the Study of Memory
    Neuron, Vol. 20, 445±468, March, 1998, Copyright 1998 by Cell Press Cognitive Neuroscience Review and the Study of Memory Brenda Milner,* Larry R. Squire,² that eventually led to the independent discipline of ex- and Eric R. Kandel³§ perimental psychology. In its early years, experimental *Montreal Neurologic Institute psychology was concerned primarily with the study of Montreal, Quebec H3A 2B4 sensation, but by the turn of the century the interests Canada of psychologists turned to behavior itselfÐlearning, ² Veterans Affairs Medical Center memory, attention, perception, and voluntary action. San Diego, California 92161 The development of simple experimental methods for and University of California studying learning and memoryÐfirst in humans by Her- San Diego, California 92093 mann Ebbinghaus in 1885 and a few years later in experi- ³ Center for Neurobiology and Behavior mental animals by Ivan Pavlov and Edgar ThorndikeÐ College of Physicians and Surgeons led to a rigorous empirical school of psychology called Columbia University behaviorism. Behaviorists, notably James B. Watson Howard Hughes Medical Institute and Burrhus F. Skinner, argued that behavior could be New York, New York 10032 studied with the precision achieved in the physical sci- ences, but only if students of behavior abandoned spec- ulation about what goes on in the mind (the brain) and The neurosciences have grown rapidly over the last half focused instead on observable aspects of behavior. For century. This growth has been stimulated by two impor- behaviorists, unobservable mental processes, espe- tant developments. First, molecular biology has trans- cially abstractions like perception, selective attention, formed cellular neurobiology and has led to a new con- and memory, were deemed inaccessible to scientific ceptual framework for signaling, a molecular framework study.
    [Show full text]
  • Dynamic Learning and Memory, Synaptic Plasticity and Neurogenesis: an Update
    MINI REVIEW ARTICLE published: 01 April 2014 BEHAVIORAL NEUROSCIENCE doi: 10.3389/fnbeh.2014.00106 Dynamic learning and memory, synaptic plasticity and neurogenesis: an update Ales Stuchlik* Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic Edited by: Mammalian memory is the result of the interaction of millions of neurons in the brain Tomiki Sumiyoshi, National Center of and their coordinated activity. Candidate mechanisms for memory are synaptic plasticity Neurology and Psychiatry, Japan changes, such as long-term potentiation (LTP). LTP is essentially an electrophysiological Reviewed by: phenomenon manifested in hours-lasting increase on postsynaptic potentials after Phillip R. Zoladz, Ohio Northern University, USA synapse tetanization. It is thought to ensure long-term changes in synaptic efficacy in Eddy A. Van Der Zee, University of distributed networks, leading to persistent changes in the behavioral patterns, actions Groningen, Netherlands and choices, which are often interpreted as the retention of information, i.e., memory. *Correspondence: Interestingly, new neurons are born in the mammalian brain and adult hippocampal Ales Stuchlik, Institute of Physiology, neurogenesis is proposed to provide a substrate for dynamic and flexible aspects of Academy of Sciences of the Czech Republic, Videnska 1803, 142 20 behavior such as pattern separation, prevention of interference, flexibility of behavior and Prague, Czech Republic memory resolution. This work provides a brief review on the memory and involvement of e-mail: [email protected] LTP and adult neurogenesis in memory phenomena. Keywords: learning, memory, behavior, synaptic plasticity, adult neurogenesis, hippocampus INTRODUCTION reviews on other issues related to this topic, such as the role of The brain, with billions of cells’ connections and plethora of transcriptional factors and various kinases (Kandel, 2012; Xia and cell types in mutual interactions, is one of the most compli- Storm, 2012).
    [Show full text]
  • A Theory on the Role of Π-Electrons of Docosahexaenoic Acid in Brain Function★ the Six Methylene-Interrupted Double Bonds and the Precision of Neural Signaling
    OCL 2018, 25(4), A403 © M. Crawford et al., Published by EDP Sciences, 2018 https://doi.org/10.1051/ocl/2018011 OCL Oilseeds & fats Crops and Lipids Available online at: www.ocl-journal.org PROCEEDINGS A theory on the role of π-electrons of docosahexaenoic acid in brain function★ The six methylene-interrupted double bonds and the precision of neural signaling Crawford MA1,*, Thabet M1, Wang Y1, Broadhurst CL2 and Schmidt WF2 1 Institute of Brain Chemistry and Human Nutrition, and Department of Cancer and Surgery, Chelsea and Westminster Hospital Campus of Imperial College, London, Room H3,34, 369 Fulham Road, SW10 9NH London, UK 2 United States Department of Agriculture, Agricultural Research Service, Beltsville, MD, USA Received 16 November 2017 – Accepted 12 February 2018 Abstract – Background: Docosahexaenoic acid (DHA) has been the dominant acyl component of the membrane phosphoglycerides in neural signaling systems since the origin of the eukaryotes. In this paper, we propose, this extreme conservation, is explained by its special electrical properties. Based on the Pauli Exclusion Principle we offer an explanation on how its six methylene interrupted double-bonds provide a special arrangement of π-electrons that offer an absolute control for the precision of the energy of the signal. Precision is not explained by standard concepts of ion movement or synaptic strengthening by enhanced protein synthesis. Yet precision is essential to visual acuity, truthful recall and the exercise of a dedicated neural pathway. Concept: Synaptic membranes have been shown to actively incorporate DHA with a high degree of selectivity. During a learning process, this biomagnification will increase the proportion of membrane DHAwith two consequential neuronal and synaptic enhancements which build into a David Marr type model of the real world: DHA induced gene expression resulting in enhanced protein synthesis; increased density of π-electrons which could provide memory blocks and provide for the preferential flow of a current in neural pathways.
    [Show full text]
  • THE BRAIN PRIZE MEETING 2016 'Synapses and Memory'
    THE BRAIN PRIZE MEETING 2016 'Synapses and Memory' WHEN Monday 31 October 2016 until Wednesday 2 November 2016 WHERE Hindsgavl Castle, Middelfart, Denmark SPEAKERS Prize winners Timothy Bliss Graham Collingridge Richard Morris Invited keynote speakers Haruhiko Bito Eleanor Maguire Paul Frankland Nigel Emptage Mark Bear Invited special lecture Todd Sacktor 'New Talent Talk' Sadegh Nabavi CERTIFICATION The meeting is certified by the University of Copenhagen, Aarhus University and the University of Southern Denmark as an external Ph.D. course worth 1 (one) ECTS point. PROGRAMME COMMITTEE Jean-François Perrier, University of Copenhagen, Martin Røssel Larsen, University of Southern Denmark, Morten Skovgaard Jensen, Aarhus University, Anders Nykjær, Danish Society of Neuroscience and Aarhus University and Jan Egebjerg, H.Lundbeck A/S. ORGANIZERS Lundbeckfonden in collaboration with University of Copenhagen, University of Southern Denmark, Aarhus University and Danish Society for Neuroscience. SPONSOR Lundbeckfonden is the sole sponsor of this meeting. AUDIENCE AND LANGUAGE The meeting is open to participants from Denmark and abroad. The meeting is open to junior and senior scientists in the field of basic as well as clinical brain research. The number of participants is limited to 120. The language is English. ABSTRACTS Participants are invited and encouraged to submit one or more abstracts. Abstracts dealing with topics outside of the main theme of the meeting are also welcome. All submitted abstracts will be presented as either oral presentation or poster presentation. Submit abstracts in pdf format max 350 words to: [email protected] att. Janne Axelsen. Deadline for abstracts: 01 October 2016. Poster size is A0: 1189 (H) x 841 (W) mm JUNIOR BRAIN PRIZE A prize of 2.500 Euros will be awarded for the best presentation.
    [Show full text]
  • The Biology of Memory: a Forty-Year Perspective
    12748 • The Journal of Neuroscience, October 14, 2009 • 29(41):12748–12756 40th Anniversary Retrospective Editor’s Note: To commemorate the 40th anniversary of the Society for Neuroscience, the editors of the Journal of Neuroscience asked several neuroscientists who have been active in the society to reflect on some of the changes they have seen in their respective fields over the last 40 years. The Biology of Memory: A Forty-Year Perspective Eric R. Kandel Department of Neuroscience, Columbia University, New York, New York 10032 In the forty years since the Society for Neuroscience was founded, our understanding of the biology of memory has progressed dramat- ically. From a historical perspective, one can discern four distinct periods of growth in neurobiological research during that time. Here I use that chronology to chart a personalized and selective course through forty years of extraordinary advances in our understanding of the biology of memory storage. Emergence of a cell biology of memory-related information is stored in the bioelectric field generated by the ag- synaptic plasticity gregate activity of many neurons; and the cellular connectionist By 1969, we had already learned from the pioneering work of approach, which derived from Santiago Ramon y Cajal’s idea Brenda Milner that certain forms of memory were stored in the (1894) that learning results from changes in the strength of the hippocampus and the medial temporal lobe. In addition, the synapse. This idea was later renamed synaptic plasticity by Kor- work of Larry Squire revealed that there are two major memory norski and incorporated into more refined models of learning by systems in the brain: declarative (explicit) and procedural (im- Hebb.
    [Show full text]
  • PATHWAYS of DISCOVERY "Science Wars"
    JANUARY PATHWAYS OF DISCOVERY "Science Wars" Neuroscience: FEBRUARY Planetary Breaking Down Scientific Barriers Sciences to the Study of Brain and Mind MARCH Eric R. Kandel and Larry R. Squire Cenomics During tlic latter part of the 20th century,, the study of the brain moved from a peripheral position within both the biological and psychological sciences to become an interdisciplinary field called neu- APRIL roscience that now occupies a central position within each discipline. This realignment occurred be- cause the biological study of the brain became incorporated inlo a common framework with ceil and Infectious molecular biology on the one side and with psychology on the other. Within this new framework, the Diseases scope of neuroscience ranges from genes to cognition, from molecules to mind. What led to the gradual incorporation of neuroscience into the central core of biology and to its alignment with psychology? From the MAY perspective of biology at the beginning of the 20th century, the Materials task of neuroscience—to understand how the brain develops Science and then functions to perceive, think, move, and remember— seemed impossibly difficult. In addition, an intellecmal barri- er separated neuroscience from biology, because the lan- JUNE guage of neuroseience was based more on neuroanatomy Ctoning and and electrophysiology than on the universal biological language of biochemistry. During the last 2 decades this Stem Cells barrier has been largely removed. A molecular neuro- seience became established by focusing on simple sys- tems where anatomy and physiology were tractable. As a juty. result, neuroseience helped delineate a general plan for Communications I neural cell function in whieh the cells of the ner\'ous sys- and Science tem are understood to be governed by variations on uni- versal biological themes.
    [Show full text]
  • Long-Term Effects of Immunostimulation on Synaptic Plasticity and Neurodegeneration
    Long-term effects of immunostimulation on synaptic plasticity and neurodegeneration Von der Fakultät für Lebenswissenschaften der Technischen Universität Carolo-Wilhelmina zu Braunschweig zur Erlangung des Grades einer Doktorin der Naturwissenschaften (Dr. rer. nat.) genehmigte D i s s e r t a t i o n von Marianna Martha Simona Beyer aus Braunschweig 1. Referent Professor Dr. Martin Korte 2. Referent Professor Dr. Reinhard Köster 3. Referent Professor Dr. Michael Heneka eingereicht am: 30.11.2015 mündliche Prüfung (Disputation) am: 19.04.2016 Druckjahr 2016 Vorveröffentlichungen der Dissertation Teilergebnisse aus dieser Arbeit wurden mit Genehmigung der Fakultät für Lebenswissenschaften, vertreten durch den Mentor der Arbeit, in den folgenden Beiträgen vorab veröffentlicht: Publikationen Parlog, A., Harsan, L.A., Zagrebelsky, M., Weller, M.*, von Elverfeldt, D., Mawrin, C., Korte, M., Dunay, I.R.: Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity, Disease Models & Mechanisms 2014 Apr; 7(4): 459–469. Tagungsbeiträge Weller, M.*, Heneka, M.T., Korte, M.: Long-term Effects of Immunostimulation on Neuronal Morphology, First N-RENNT Symposium on Neuroinfectiology, Hannover (2014) Weller, M.*, Heneka, M.T., Korte, M.: Long-term effects of an immunostimulation on neuronal function and morphology, 9th FENS Forum of Neuroscience, Mailand (2014) Young investigator oral: Beyer, M., Heneka, M.T., Korte, M.: Long-term influences of an immune stimulation on neuronal structure and plasticity, 11th Göttingen Meeting
    [Show full text]
  • Análisis Documental De Los Efectos Del Estrés En Los Procesos De Aprendizaje Y Memoria, Desde Una Perspectiva Neurocientífica Y Bioquímica
    ANÁLISIS DOCUMENTAL DE LOS EFECTOS DEL ESTRÉS EN LOS PROCESOS DE APRENDIZAJE Y MEMORIA, DESDE UNA PERSPECTIVA NEUROCIENTÍFICA Y BIOQUÍMICA SARA VIVIANA BENAVIDES PINZÓN UNIVERSIDAD DISTRITAL FRANCISCO JOSÉ DE CALDAS FACULTAD DE CIENCIAS Y EDUCACIÓN PROYECTO CURRICULAR DE LICENCIATURA EN QUÍMICA BOGOTÁ - 2016 EFECTOS DEL ESTRÉS EN LOS PROCESOS DE APRENDIZAJE Y MEMORIA, DESDE UNA PERSPECTIVA NEUROCIENTÍFICA Y BIOQUÍMICA SARA VIVIANA BENAVIDES PINZÓN DIRECTORA DOCENTE CANDIDATA A PhD. MARÍA LUISA ARAUJO UNIVERSIDAD DISTRITAL FRANCISCO JOSÉ DE CALDAS FACULTAD DE CIENCIAS Y EDUCACIÓN PROYECTO CURRICULAR DE LICENCIATURA EN QUÍMICA BOGOTÁ - 2016 Nota de Aceptación ______________________ ______________________ ______________________ _____________________ Directora: Maria Luisa Araujo ________________________ Jurado 1 A Dios que es la fortaleza de mi vida. A mi Daniel que es el motor que me impulsó a ser mejor. A Papá que desde el cielo me siguió animando. A Mamá que siempre creyó en mí. AGRADECIMIENTOS A Dios gracias por darme la fuerza necesaria para culminar esta etapa del camino, no fue fácil, pero tu amor me sustentó y me llevó a perseverar. A Mi Daniel, porque eres el motivo por el cual cada día quiero ser mejor, para que el día que crezcas yo pueda ser tu mejor ejemplo, gracias hijo por darme fuerza, motivación y una razón para seguir con este proyecto hasta la meta. Haces más tú por mí de lo que yo lograré hacer por ti. A Papá, porque aunque ya no estes y no puedas verme hoy, creías en mi y en que lo lograría. A Mamá gracias, porque nunca perdiste la fé en mí, aunque tropecé muchas veces me apoyaste, me empujaste y sé que anhelabas en tu corazón este día.
    [Show full text]
  • Downloaded by Mcgill University 10/04/2015 14:12:50
    CELLULAR MECHANISMS OF BRAIN-DERIVED NEUROTROPHIC FACTOR MEDIATED SYNAPSE REORGANIZATION FOLLOWING HIPPOCAMPAL INJURY By, Raminder Gill, B. Sc. Department of Pharmacology & Therapeutics McGill University Montréal, Québec, Canada April 2015 A thesis submitted to McGill University in partial fulfillment of the requirements of the degree of Doctor of Philosophy © Raminder Gill, 2015 TABLE OF CONTENTS TABLE OF CONTENTS .............................................................................................................. i ABSTRACT .................................................................................................................................. iv RÉSUMÉ ..................................................................................................................................... vii ACKNOWLEDGMENTS ............................................................................................................ x ABBREVIATIONS ..................................................................................................................... xii PREFACE ................................................................................................................................... xiv CONTRIBUTIONS TO ORIGINAL SCIENCE .................................................................... xvi CHAPTER 1. INTRODUCTION ................................................................................................ 1 1.1. GENERAL BACKGROUND ...........................................................................................
    [Show full text]