Retinal Tear and Detachment. the Need for Early Diagnosis
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Advice for Floaters and Flashing Lights for Primary Care
UK Vision Strategy RCGP – Royal College of General Practitioners Advice for Floaters and Flashing Lights for primary care Key learning points • Floaters and flashing lights usually signify age-related liquefaction of the vitreous gel and its separation from the retina. • Although most people sometimes see floaters in their vision, abrupt onset of floaters and / or flashing lights usually indicates acute vitreous gel detachment from the posterior retina (PVD). • Posterior vitreous detachment is associated with retinal tear in a minority of cases. Untreated retinal tear may lead to retinal detachment (RD) which may result in permanent vision loss. • All sudden onset floaters and / or flashing lights should be referred for retinal examination. • The differential diagnosis of floaters and flashing lights includes vitreous haemorrhage, inflammatory eye disease and very rarely, malignancy. Vitreous anatomy, ageing and retinal tears • The vitreous is a water-based gel containing collagen that fills the space behind the crystalline lens. • Degeneration of the collagen gel scaffold occurs throughout life and attachment to the retina loosens. The collagen fibrils coalesce, the vitreous becomes increasingly liquefied and gel opacities and fluid vitreous pockets throw shadows on to the retina resulting in perception of floaters. • As the gel collapses and shrinks, it exerts traction on peripheral retina. This may cause flashing lights to be seen (‘photopsia’ is the sensation of light in the absence of an external light stimulus). • Eventually, the vitreous separates from the posterior retina. Supported by Why is this important? • Acute PVD may cause retinal tear in some patients because of traction on the retina especially at the equator of the eye where the retina is thinner. -
The Distribution of Immune Cells in the Uveal Tract of the Normal Eye
THE DISTRIBUTION OF IMMUNE CELLS IN THE UVEAL TRACT OF THE NORMAL EYE PAUL G. McMENAMIN Perth, Western Australia SUMMARY function of these cells in the normal iris, ciliary body Inflammatory and immune-mediated diseases of the and choroid. The role of such cell types in ocular eye are not purely the consequence of infiltrating inflammation, which will be discussed by other inflammatory cells but may be initiated or propagated authors in this issue, is not the major focus of this by immune cells which are resident or trafficking review; however, a few issues will be briefly through the normal eye. The uveal tract in particular considered where appropriate. is the major site of many such cells, including resident tissue macro phages, dendritic cells and mast cells. This MACRO PHAGES review considers the distribution and location of these and other cells in the iris, ciliary body and choroid in Mononuclear phagocytes arise from bone marrow the normal eye. The uveal tract contains rich networks precursors and after a brief journey in the blood as of both resident macrophages and MHe class 11+ monocytes immigrate into tissues to become macro dendritic cells. The latter appear strategically located to phages. In their mature form they are widely act as sentinels for capturing and sampling blood-borne distributed throughout the body. Macrophages are and intraocular antigens. Large numbers of mast cells professional phagocytes and play a pivotal role as are present in the choroid of most species but are effector cells in cell-mediated immunity and inflam virtually absent from the anterior uvea in many mation.1 In addition, due to their active secretion of a laboratory animals; however, the human iris does range of important biologically active molecules such contain mast cells. -
Ciliary Zonule Sclera (Suspensory Choroid Ligament)
ACTIVITIES Complete Diagrams PNS 18 and 19 Complete PNS 23 Worksheet 3 #1 only Complete PNS 24 Practice Quiz THE SPECIAL SENSES Introduction Vision RECEPTORS Structures designed to respond to stimuli Variable complexity GENERAL PROPERTIES OF RECEPTORS Transducers Receptor potential Generator potential GENERAL PROPERTIES OF RECEPTORS Stimulus causing receptor potentials Generator potential in afferent neuron Nerve impulse SENSATION AND PERCEPTION Stimulatory input Conscious level = perception Awareness = sensation GENERAL PROPERTIES OF RECEPTORS Information conveyed by receptors . Modality . Location . Intensity . Duration ADAPTATION Reduction in rate of impulse transmission when stimulus is prolonged CLASSIFICATION OF RECEPTORS Stimulus Modality . Chemoreceptors . Thermoreceptors . Nociceptors . Mechanoreceptors . Photoreceptors CLASSIFICATION OF RECEPTORS Origin of stimuli . Exteroceptors . Interoceptors . Proprioceptors SPECIAL SENSES Vision Hearing Olfaction Gustation VISION INTRODUCTION 70% of all sensory receptors are in the eye Nearly half of the cerebral cortex is involved in processing visual information Optic nerve is one of body’s largest nerve tracts VISION INTRODUCTION The eye is a photoreceptor organ Refraction Conversion (transduction) of light into AP’s Information is interpreted in cerebral cortex Eyebrow Eyelid Eyelashes Site where conjunctiva merges with cornea Palpebral fissure Lateral commissure Eyelid Medial commissure (a) Surface anatomy of the right eye Figure 15.1a Orbicularis oculi muscle -
The Proteomes of the Human Eye, a Highly Compartmentalized Organ
Proteomics 17, 1–2, 2017, 1600340 DOI 10.1002/pmic.201600340 (1 of 3) 1600340 The proteomes of the human eye, a highly compartmentalized organ Gilbert S. Omenn Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA Proteomics has now published a series of Dataset Briefs on the EyeOme from the HUPO Received: November 2, 2016 Human Proteome Project with high-quality analyses of the proteomes of these compartments Accepted: November 4, 2016 of the human eye: retina, iris, ciliary body, retinal pigment epithelium/choroid, retrobulbar optic nerve, and sclera, with 3436, 2929, 2867, 2755, 2711, and 1945 proteins, respectively. These proteomics resources represent a useful starting point for a broad range of research aimed at developing preventive and therapeutic interventions for the various causes of blindness. Keywords: Biomedicine / Biology and Disease-driven Human Proteome Project / End Blindness by 2020 / Eye proteome / EyeOme / Human Proteome Project See accompanying articles in the EyeOme series: http://dx.doi.org/10.1002/pmic.201600229; http://dx.doi.org/10.1002/pmic.201500188; http://dx.doi.org/10.1002/pmic.201400397 Proteomics has now published a series of four papers on compartments of the eye as shown in Fig. 1. As was noted [5], the human eye proteome [1–4]. Under the aegis of the Hu- it was not feasible to assess the quality of the data or estimate man Proteome Organization Biology and Disease-driven Hu- numbers of likely false positives in the heterogeneous studies man Proteome Project (HPP), the EyeOme was organized by from which these findings were summarized. -
Pupil Iris Ciliary Body
Eye iris pupil ciliary body Eyeball Anterior segment Posterior segment Pars caeca retinae Eyeball Corpus ciliare Procesus ciliares Sclera Iris Cornea Eyebulb wall Posterior Anterior segment segment Tunica externa Sclera Cornea (fibrosa) Tunica media Chorioidea Iris, Corpus (vasculosa) ciliare Tunica interna Pars optica Pars caeca (nervosa) retinae retinae Eyeball Fibrous tunic - tunica externa oculi • Cornea • Sclera limbus conjunctiva Cornea 1. Stratified squamous epithelium 2. Bowman´s membrane-anterior limiting lamina 3. Substantia propria cornae − 200 - 250 layers of regularly organized collagen fibrils − fibrocytes /keratocytes/ 4. Descemet´s membrane-posterior limiting lamina − the basement membrane of the posterior endothelium − Posterior endothelium − simple squamous epithelium Cornea Vascular tunic - tunica media oculi - Choroid ch - loose c.t. with network of blood vessels, numerous pigment cells c - Ciliary body - loose c.t. with smooth muscle cells – musculus i ciliaris /accomodation/ - ciliary processes – generate aqueous humor - Iris - central opening of the iris - the pupil Choroid 1. Lamina suprachoroidea /lamina fusca sclerae/ 2. Lamina vasculosa 3. Lamina chorocapillaris 4. Lamina vitrea /Bruch´s membrane/ L. suprachoroidea - perichoroidal space with melanocytes, collagen and elastic sclera fibers, fibroblasts, macrophages, lymphocytes L. vasculosa – blood supply – parallelní veins – c. ciliare choroid L. chorocapilaris – capillary plexus for retina L. vitrea – five layers, including balsal retina lamina of chorid endothelium and retinal pigment epithelium, collagen and elastic fibers. Choroid Ciliary body - structure ciliary processes m. ciliaris ciliary epithelium - outer cell layer is pigmented, inner cell layer is nonpigmented (pars caeca retinae) Ciliary body Epithelium two layers – basal, pigmented (fuscin), surface w/o pigment - Continuous with optical part of retina = pars caeca retinae processus ciliares m. -
NEUROLOGY in TABLE.Pdf
ZAPORIZHZHIA STATE MEDICAL UNIVERSITY DEPARTMENT OF NEUROLOGY DISEASES NEUROLOGY IN TABLE (General neurology) for practical employments to the students of the IV course of medical faculty Zaporizhzhia, 2015 2 It is approved on meeting of the Central methodical advice Zaporozhye state medical university (the protocol № 6, 20.05.2015) and is recommended for use in scholastic process. Authors: doctor of the medical sciences, professor Kozyolkin O.A. candidate of the medical sciences, assistant professor Vizir I.V. candidate of the medical sciences, assistant professor Sikorskaya M.V. Kozyolkin O. A. Neurology in table (General neurology) : for practical employments to the students of the IV course of medical faculty / O. A. Kozyolkin, I. V. Vizir, M. V. Sikorskaya. – Zaporizhzhia : [ZSMU], 2015. – 94 p. 3 CONTENTS 1. Sensitive function …………………………………………………………………….4 2. Reflex-motor function of the nervous system. Syndromes of movement disorders ……………………………………………………………………………….10 3. The extrapyramidal system and syndromes of its lesion …………………………...21 4. The cerebellum and it’s pathology ………………………………………………….27 5. Pathology of vegetative nervous system ……………………………………………34 6. Cranial nerves and syndromes of its lesion …………………………………………44 7. The brain cortex. Disturbances of higher cerebral function ………………………..65 8. Disturbances of consciousness ……………………………………………………...71 9. Cerebrospinal fluid. Meningealand hypertensive syndromes ………………………75 10. Additional methods in neurology ………………………………………………….82 STUDY DESING PATIENT BY A PHYSICIAN NEUROLOGIST -
Eye External Anatomy of Eye Accessory Structures
4/22/16 Eye Bio 40B Dr. Kandula External Anatomy of Eye Accessory Structures l Eyebrows l Levator Palpebrae Superioris - opens eye l Eyelashes l Ciliary glands – modified sweat glands l Small sebaceous glands l Sty is inflamed ciliary glands or small sebaceous glands 1 4/22/16 Terms: Lacrimal gland and duct Surface of eye Lacrimal puncta Lacrimal sac Nasolacrimal duct Nasal cavity Tears / Lacrimal fluid l a watery physiologic saline, with a plasma-like consistency, l contains the bactericidal enzyme lysozyme; l it moistens the conjunctiva and cornea, l provides nutrients and dissolved O2 to the cornea. Extrinsic Muscles of the Eye: Lateral/medial rectus Important to know Superior/inferior rectus actions and nerve Superior/inferior oblique supply in table 2 4/22/16 Extrinsic Eye Muscles • Eye movements controlled by six extrinsic eye muscles Four recti muscles § Superior rectus – moves eyeball superiorly supplied by Cranial Nerve III § Inferior rectus - moves eyeball inferiorly supplied by Cranial Nerve III § Lateral rectus - moves eyeball laterally supplied by Cranial Nerve VI § Medial rectus - moves eyeball medially supplied by Cranial Nerve III Extrinsic Eye Muscles Two oblique muscles rotate eyeball on its axis § Superior oblique rotates eyeball inferiorly and laterally and is supplied by Cranial Nerve IV § Inferior oblique rotates superiorly and laterally and is supplied by Cranial Nerve III Convergence of the Eyes l Binocular vision in humans has both eyes looking at the same object l As you look at an object close to your face, -
Anatomy & Physiology of The
Anatomy & Physiology of The Eye 2017-2018 Done By: 433 Team Abdullah M. Khattab Important Doctor’s Notes Extra Abdullah AlOmair Resources: Team 433, Doctors Notes, Vaughan & Asbury’s General ophthalmology. Editing File Embryology of The Eye ............................................................................................. 2 ● Defects: ........................................................................................................................... 2 Development of The Eye After Birth .......................................................................... 3 ● Refractive power depends on two factors: ...................................................................... 3 The Orbit ................................................................................................................... 4 ● Seven bones contribute the bony orbit and surrounded by nasal sinuses. .................... 4 ● The orbital wall, pear-like shaped, formed by: ................................................................ 4 ● Structures Passing Through the Optic Openings: ........................................................... 4 Extraocular Muscles .................................................................................................. 1 ● Anatomy .......................................................................................................................... 1 ● Notes: .............................................................................................................................. 1 ● Field of action: -
The Neuro-Ophthalmology of Cerebrovascular Disease*
The Neuro-Ophthalmology of Cerebrovascular Disease* JOHN W. HARBISON, M.D. Associate Professor, Department of Neurology, Medical College of Virginia, Health Sciences Division of Virginia Commonwealth University, Richmond The neuro-ophthalmology of cerebrovascular however, are important pieces to the puzzle the disease is a vast plain of neuro-ophthalmic vistas, patient may present. A wide variety of afflictions encompassing virtually all areas of disturbances of of the eye occur by virtue of its arterial dependence the eye-brain mechanism. This paper will be re on the internal carotid artery. It is also logical to stricted to those areas of the neuro-ophthalmology assume that changes in the distribution of the of cerebrovascular disease which one might con ophthalmic artery may reflect changes taking place sider advances in its clinical diagnosis and treatment. in other channels of the internal carotid artery Most practitioners of medical and surgical neu the middle cerebral, the anterior cerebral, and de rology give little thought to that aspect of medicine pending upon anatomic variations, the posterior generally accepted as the ideal approach to any cerebral artery. This paper will discuss these afflic disease-prevention. Usually when one is presented tions, those common as well as rare, those well with an illness of the central nervous system, it recognized, and those frequently overlooked. seems to be a fait accompli. Although prevention Historically, the recognition of the eye as an is by no means new, certain aspects of it qualify index of cerebrovascular disease presents an inter as advances. There is one advance in cerebrovascu rupted course. Virchow is credited with the first lar disease in which prevention plays a significant autopsy correlation of ipsilateral blindness with role. -
Home>>Common Retinal & Ophthalmic Disorders
Common Retinal & Ophthalmic Disorders Cataract Central Serous Retinopathy Cystoid Macular Edema (Retinal Swelling) Diabetic Retinopathy Floaters Glaucoma Macular degeneration Macular Hole Macular Pucker - Epiretinal Membrane Neovascular Glaucoma Nevi and Pigmented Lesions of the Choroid Posterior Vitreous Detachment Proliferative Vitreoretinopathy (PVR) Retinal Tear and Detachment Retinal Artery and Vein Occlusion Retinitis Uveitis (Ocular Inflammation) White Dot Syndromes Anatomy and Function of the Eye (Short course in physiology of vision) Cataract Overview Any lack of clarity in the natural lens of the eye is called a cataract. In time, all of us develop cataracts. One experiences blurred vision in one or both eyes – and this cloudiness cannot be corrected with glasses or contact lens. Cataracts are frequent in seniors and can variably disturb reading and driving. Figure 1: Mature cataract: complete opacification of the lens. Cause Most cataracts are age-related. Diabetes is the most common predisposing condition. Excessive sun exposure also contributes to lens opacity. Less frequent causes include trauma, drugs (eg, systemic steroids), birth defects, neonatal infection and genetic/metabolic abnormalities. Natural History Age-related cataracts generally progress slowly. There is no known eye-drop, vitamin or drug to retard or reverse the condition. Treatment Surgery is the only option. Eye surgeons will perform cataract extraction when there is a functional deficit – some impairment of lifestyle of concern to the patient. Central Serous Retinopathy (CSR) Overview Central serous retinopathy is a condition in which a blister of clear fluid collects beneath the macula to cause acute visual blurring and distortion (Figure 2). Central serous retinochoroidopathy Left: Accumulation of clear fluid beneath the retina. -
Visual Perceptual Abnormalities: Hallucinations and Illusions John W
SEMINARS IN NEUROLOGY—VOLUME 20, NO. 1 2000 Visual Perceptual Abnormalities: Hallucinations and Illusions John W. Norton, M.D.* and James J. Corbett, M.D.‡,§ ABSTRACT Visual perceptual abnormalities may be caused by diverse etiologies which span the fields of psychiatry and neurology. This article reviews the differential diagnosis of visual perceptual abnormalities from both a neurological and a psychiatric perspec- tive. Psychiatric etiologies include mania, depression, substance dependence, and schizophrenia. Common neurological causes include migraine, epilepsy, delirium, dementia, tumor, and stroke. The phenomena of palinopsia, oscillopsia, dysmetrop- sia, and polyopia among others are also reviewed. A systematic approach to the many causes of illusions and hallucinations may help to achieve an accurate diag- nosis, and a more focused evaluation and treatment plan for patients who develop visual perceptual abnormalities. This article provides the practicing neurologist with a practical understanding and approach to patients with these clinical symptoms. Keywords: Illusion, hallucination, perceptual abnormalities, oscillopsia, polyopia, diplopia, palinopsia, dysmetropsia, visual allesthesia, visual synthesia, visual dyses- thesia, sensation of environmental tilt, psychiatric, neurological The topic of visual perceptual abnormalities, spe- enable the clinician to understand the phenomenology cifically hallucinations and illusions, spans many fields while diagnosing and treating patients who present with of medicine. The most prominent among these are neu- these problems. rology, ophthalmology, and psychiatry. A wide variety of An illusion is the misperception of a stimulus that is pathological processes can lead to perceptual abnormali- present in the external environment.1 An example is ties. The purpose of this presentation is to review the when an elderly demented individual interprets a chair in neurological and psychiatric differential diagnoses of vi- a poorly lit room as a person. -
Forward and Inward Movement of the Ciliary Muscle Apex with Accommodation in Adults
Forward and Inward Movement of the Ciliary Muscle Apex with Accommodation in Adults THESIS Presented in Partial Fulfillment of the Requirements for the Degree Master of Science in the Graduate School of The Ohio State University By Trang Pham Prosak Graduate Program in Vision Science The Ohio State University 2014 Master's Examination Committee: Melissa D. Bailey, OD, PhD, Advisor Donald O. Mutti, OD, PhD Marjean Kulp, OD, PhD Copyright by Trang Pham Prosak 2014 Abstract Purpose: to study the inward and forward movement of the ciliary muscle during accommodation and to investigate the effects of one hour of reading on the ciliary muscle behavior in young adults. Methods: Subjects included 23 young adults with a mean age of 23.7 ± 1.9 years. Images of the temporal ciliary muscle of the right eye were obtained using the Visante™ Anterior Segment Ocular Coherence Tomography while accommodative response was monitored simultaneously by the Power-Refractor. Four images were taken at each accommodative response level (0, 4.0 and 6.0 D) before and after one hour of reading. Ciliary muscle thickness was measured at every 0.25 mm posterior to the scleral spur. SSMAX, which is the distance between scleral spur and the thickest point of the muscle (CMTMAX), was also measured. The change in the ciliary muscle thickness and SSMAX with accommodation from 0 to 4.0 D and 0 to 6.0 D was calculated. Paired t-tests were used to determine if the ciliary muscle thickness and SSMAX for the 4.0 and 6.0 diopters of accommodative response were different after one hour of reading.